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Journal articles on the topic 'Collage covalent'

Author: Grafiati

Published: 19 October 2024

Last updated: 31 July 2025

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1

DIAB, Mohammad, Jiann-Jiu WU, and David R. EYRE. "Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites." Biochemical Journal 314, no. 1 (1996): 327–32. http://dx.doi.org/10.1042/bj3140327.

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Type IX collagen, a quantitatively minor collagenous component of cartilage, is known to be associated with and covalently cross-linked to type II collagen fibrils in chick and bovine cartilage. Type IX collagen molecules have also been shown to form covalent cross-links with each other in bovine cartilage. In the present study we demonstrate by structural analysis and location of cross-linking sites that, in human cartilage, type IX collagen is covalently cross-linked to type II collagen and to other molecules of type IX collagen. We also present evidence that, if the proteoglycan form of typ

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2

Blumberg, B., L. I. Fessler, M. Kurkinen, and J. H. Fessler. "Biosynthesis and supramolecular assembly of procollagen IV in neonatal lung." Journal of Cell Biology 103, no. 5 (1986): 1711–19. http://dx.doi.org/10.1083/jcb.103.5.1711.

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The rate of biosynthesis of procollagen IV, the principal collagen of basement membranes, and the concentration of specific RNAs coding for procollagen IV were measured in neonatal rat lungs. Both decreased sharply at birth and then recovered again a few days later. The supramolecular assembly of procollagen IV was followed in neonatal rat, mouse, and chick lungs, which actively elaborate endothelial and alveolar basement membranes, and in chick embryo gizzard which is rich in smooth muscle. The tetramer of four procollagen IV molecules linked covalently through their amino ends was isolated a

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3

Ao, Haiyong, Youtao Xie, Honglue Tan, et al. "Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings." Journal of The Royal Society Interface 10, no. 84 (2013): 20130070. http://dx.doi.org/10.1098/rsif.2013.0070.

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Layer-by-layer (LBL) self-assembly technique has been proved to be a highly effective method to immobilize the main components of the extracellular matrix such as collagen and hyaluronic acid on titanium-based implants and form a polyelectrolyte multilayer (PEM) film by electrostatic interaction. However, the formed PEM film is unstable in the physiological environment and affects the long-time effectiveness of PEM film. In this study, a modified LBL technology has been developed to fabricate a stable collagen/hyaluronic acid (Col/HA) PEM film on titanium coating (TC) by introducing covalent i

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4

SEYER, JEROME M., and ANDREW H. KANG. "Covalent Structure of Collagen." Annals of the New York Academy of Sciences 460, no. 1 Biology, Chem (1985): 503–5. http://dx.doi.org/10.1111/j.1749-6632.1985.tb51223.x.

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5

Colman, RW, WR Figures, LM Scearce, AM Strimpler, FX Zhou, and AK Rao. "Inhibition of collagen-induced platelet activation by 5'-p- fluorosulfonylbenzoyl adenosine: evidence for an adenosine diphosphate requirement and synergistic influence of prostaglandin endoperoxides." Blood 68, no. 2 (1986): 565–70. http://dx.doi.org/10.1182/blood.v68.2.565.565.

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Abstract The relative roles of platelet autacoids such as adenosine diphosphate (ADP), prostaglandin endoperoxides, and thromboxane A2 (TXA2) in collagen-induced platelet activation are not fully understood. We reexamined this relationship using the ADP affinity analogue, 5'-p- fluorosulfonylbenzoyl adenosine (FSBA), which covalently modifies a receptor for ADP on the platelet surface, thereby inhibiting ADP- induced platelet activation. Collagen-induced shape change, aggregation, and fibrinogen binding were each fully inhibited under conditions in which FSBA is covalently incorporated and cou

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6

Colman, RW, WR Figures, LM Scearce, AM Strimpler, FX Zhou, and AK Rao. "Inhibition of collagen-induced platelet activation by 5'-p- fluorosulfonylbenzoyl adenosine: evidence for an adenosine diphosphate requirement and synergistic influence of prostaglandin endoperoxides." Blood 68, no. 2 (1986): 565–70. http://dx.doi.org/10.1182/blood.v68.2.565.bloodjournal682565.

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The relative roles of platelet autacoids such as adenosine diphosphate (ADP), prostaglandin endoperoxides, and thromboxane A2 (TXA2) in collagen-induced platelet activation are not fully understood. We reexamined this relationship using the ADP affinity analogue, 5'-p- fluorosulfonylbenzoyl adenosine (FSBA), which covalently modifies a receptor for ADP on the platelet surface, thereby inhibiting ADP- induced platelet activation. Collagen-induced shape change, aggregation, and fibrinogen binding were each fully inhibited under conditions in which FSBA is covalently incorporated and could not be

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7

Gwiazda, Marcin, Sheetal K. Bhardwaj, Ewa Kijeńska-Gawrońska, Wojciech Swieszkowski, Unni Sivasankaran, and Ajeet Kaushik. "Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System." Biosensors 11, no. 7 (2021): 227. http://dx.doi.org/10.3390/bios11070227.

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This research presents an electrochemical immunosensor for collagen I detection using a self-assembled monolayer (SAM) of gold nanoparticles (AuNPs) and covalently immobilized half-reduced monoclonal antibody as a receptor; this allowed for the validation of the collagen I concentration through two different independent methods: electrochemically by Electrochemical Impedance Spectroscopy (EIS), and optically by Surface Plasmon Resonance (SPR). The high unique advantage of the proposed sensor is based on the performance of the stable covalent immobilization of the AuNPs and enzymatically reduce

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8

Siverino, Claudia, Shorouk Fahmy-Garcia, Didem Mumcuoglu, et al. "Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 (BMP2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo." International Journal of Molecular Sciences 23, no. 7 (2022): 3928. http://dx.doi.org/10.3390/ijms23073928.

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For the treatment of large bone defects, the commonly used technique of autologous bone grafting presents several drawbacks and limitations. With the discovery of the bone-inducing capabilities of bone morphogenetic protein 2 (BMP2), several delivery techniques were developed and translated to clinical applications. Implantation of scaffolds containing adsorbed BMP2 showed promising results. However, off-label use of this protein-scaffold combination caused severe complications due to an uncontrolled release of the growth factor, which has to be applied in supraphysiological doses in order to

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9

Hanssen, Eric, Betty Reinboth та Mark A. Gibson. "Covalent and Non-covalent Interactions of βig-h3 with Collagen VI". Journal of Biological Chemistry 278, № 27 (2003): 24334–41. http://dx.doi.org/10.1074/jbc.m303455200.

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10

SEYER, JEROME M., and ANDREW H. KANG. "Covalent Structure of Type V Collagen." Annals of the New York Academy of Sciences 580, no. 1 Structure, Mo (1990): 427–29. http://dx.doi.org/10.1111/j.1749-6632.1990.tb17950.x.

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11

Leivo, Joni, Sanni Virjula, Sari Vanhatupa, et al. "A durable and biocompatible ascorbic acid-based covalent coating method of polydimethylsiloxane for dynamic cell culture." Journal of The Royal Society Interface 14, no. 132 (2017): 20170318. http://dx.doi.org/10.1098/rsif.2017.0318.

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Polydimethylsiloxane (PDMS) is widely used in dynamic biological microfluidic applications. As a highly hydrophobic material, native PDMS does not support cell attachment and culture, especially in dynamic conditions. Previous covalent coating methods use glutaraldehyde (GA) which, however, is cytotoxic. This paper introduces a novel and simple method for binding collagen type I covalently on PDMS using ascorbic acid (AA) as a cross-linker instead of GA. We compare the novel method against physisorption and GA cross-linker-based methods. The coatings are characterized by immunostaining, contac

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12

Wu, J. J., D. R. Eyre, and H. S. Slayter. "Type VI collagen of the intervertebral disc. Biochemical and electron-microscopic characterization of the native protein." Biochemical Journal 248, no. 2 (1987): 373–81. http://dx.doi.org/10.1042/bj2480373.

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The collagen framework of the intervertebral disc contains two major fibril-forming collagens, types I and II. Smaller amounts of other types of collagen are also present. On examination of the nature and distribution of these minor collagens within bovine disc tissue, type VI collagen was found to be unusually abundant. It accounted for about 20% of the total collagen in calf nucleus pulposus, and about 5% in the annulus fibrosus. It was discovered by serially digesting disc tissue with chondroitin ABC lyase and Streptomyces hyaluronidase that native covalent polymers of type VI collagen coul

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13

Chen, Qian, John M. Fitch, Cathy Linsenmayer, and Thomas F. Linsenmayer. "Type X collagen: covalent crosslinking to hypertrophic cartilage-collagen fibrils." Bone and Mineral 17, no. 2 (1992): 223–27. http://dx.doi.org/10.1016/0169-6009(92)90741-u.

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14

Pence, Jacquelyn C., Emily A. Gonnerman, Ryan C. Bailey, and Brendan A. C. Harley. "Strategies to balance covalent and non-covalent biomolecule attachment within collagen-GAG biomaterials." Biomater. Sci. 2, no. 9 (2014): 1296–304. http://dx.doi.org/10.1039/c4bm00193a.

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Incorporating selective biomolecular cues within a biomaterial requires balancing covalent attachment versus non-specific fouling. We use a model collagen-GAG scaffold to define the impact of processing conditions on immobilization versus fouling.

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15

Li, I.-Che, Sarah A. H. Hulgan, Douglas R. Walker, Richard W. Farndale, Jeffrey D. Hartgerink, and Abhishek A. Jalan. "Covalent Capture of a Heterotrimeric Collagen Helix." Organic Letters 21, no. 14 (2019): 5480–84. http://dx.doi.org/10.1021/acs.orglett.9b01771.

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16

SCHUPPAN, Detlef, Robert W. GLANVILLE, and Rupert TIMPL. "Covalent Structure of Mouse Type-IV Collagen." European Journal of Biochemistry 123, no. 3 (2005): 505–12. http://dx.doi.org/10.1111/j.1432-1033.1982.tb06560.x.

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17

Bisconte, Angelina, Ronald Hill, Michael Bradshaw, et al. "Efficacy in collagen induced arthritis models with a selective, reversible covalent Bruton’s tyrosine kinase inhibitor PRN473 is driven by durable target occupancy rather than extended plasma exposure (THER5P.904)." Journal of Immunology 194, no. 1_Supplement (2015): 139.6. http://dx.doi.org/10.4049/jimmunol.194.supp.139.6.

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Abstract Bruton’s Tyrosine Kinase (BTK) is an essential signaling element downstream of the B-cell receptor (BCR). Inhibition of BTK activity in B cells produces phenotypic changes consistent with blockade of the BCR, including inhibition of cell proliferation, differentiation, maturation, and survival. A selective BTK inhibitor has the potential to treat diseases involving inflammation and autoimmunity. Using Principia Biopharma’s proprietary Tailored Covalency™ technology, we discovered PRN473, a reversible covalent BTK inhibitor that selectively binds BTK with a slow off-rate as assessed in

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18

He, Yingcong, Ting Zhu, Lei Liu, Xuetao Shi, and Zhengmei Lin. "Modifying collagen with alendronate sodium for bone regeneration applications." RSC Advances 8, no. 30 (2018): 16762–72. http://dx.doi.org/10.1039/c8ra01872c.

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19

Zhang, Tingting, Hong Chen, Yajie Zhang, et al. "Osteogenic differentiation of BMSCs in collagen-based 3D scaffolds." New Journal of Chemistry 43, no. 4 (2019): 1980–86. http://dx.doi.org/10.1039/c8nj04100h.

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20

Sulekh, Chandra, Raizada Smriti, and Rani Soni. "Lanthanide complexes of tetradentate macrocyclic ligand Synthesis and spectroscopic investigation." Journal of Indian Chemical Society Vol. 85, Aug 2008 (2008): 783–91. https://doi.org/10.5281/zenodo.5819416.

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Department of Chemistry, Zakir Husain College (University of Delhi), JLN Marg, New Delhi-11 0 002, India Department of Chemistry, M. M. H. College, Ghaziabad-20 1 001, Uttar Pradesh, India <em>E-mail :</em> schandra _ OO@yahoo. com; soni _ teotia81 @yahoo. co. in       Fax : 91-11-23215906 <em>Manuscript received 15 October 2007, revised 13 May 2008, accepted 16 May 2008</em> In the present paper, the lanthanide complexes derived from (1,5,8,12-tetraaza-2,4,9,11-tetramethyl cyclotetraaza-1,4,8,11-tetraene) were synthesized. The general composition of the complexes is [Ln(L)

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21

Jiang, Bo, Zhi Hong Wu, Jing Ying Zeng, et al. "Collagenous Molecule Immobilization on Hydroxyapatite Surface." Key Engineering Materials 330-332 (February 2007): 741–44. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.741.

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Collagenous molecule was successfully immobilized to hydroxyapatite (HA) surface through a molecular bridge (2-Hydroxyethyl acrylate, HEMA) that was grafted to the surface with covalent bond by gamma irradiation. Hydroxyapatite modified by atelocollagen had been characterized by several surface sensitive techniques, such as FT-IR, SEM, XPS. The investigations showed that the collagen, a bioactive macromolecule, was immobilized on the HA surface through covalent bond.

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22

Wu, Jiann-Jiu, and David R. Eyre. "Covalent Interactions of Type IX Collagen in Cartilage." Connective Tissue Research 20, no. 1-4 (1989): 241–45. http://dx.doi.org/10.3109/03008208909023893.

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23

Velichko, T. I., A. N. Shtopenko, N. V. Fedoseeva, and G. S. Katrukha. "Covalent immobilization of heparin on a collagen film." Chemistry of Natural Compounds 23, no. 5 (1987): 582–85. http://dx.doi.org/10.1007/bf00598679.

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24

Jukkola, Arja, and Onni Niemelä. "Covalent binding of acetaldehyde to type III collagen." Biochemical and Biophysical Research Communications 159, no. 1 (1989): 163–69. http://dx.doi.org/10.1016/0006-291x(89)92418-2.

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25

Priem, Christoph, and Armin Geyer. "Reversible Covalent End‐Capping of Collagen Model Peptides." Chemistry – A European Journal 25, no. 63 (2019): 14278–83. http://dx.doi.org/10.1002/chem.201903460.

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26

Liang, He, Stephen J. Russell, David J. Wood, and Giuseppe Tronci. "A hydroxamic acid–methacrylated collagen conjugate for the modulation of inflammation-related MMP upregulation." Journal of Materials Chemistry B 6, no. 22 (2018): 3703–15. http://dx.doi.org/10.1039/c7tb03035e.

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27

Yamauchi, Mitsuo, and Marnisa Sricholpech. "Lysine post-translational modifications of collagen." Essays in Biochemistry 52 (May 25, 2012): 113–33. http://dx.doi.org/10.1042/bse0520113.

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Type I collagen is the most abundant structural protein in vertebrates. It is a heterotrimeric molecule composed of two α1 chains and one α2 chain, forming a long uninterrupted triple helical structure with short non-triple helical telopeptides at both the N- and C-termini. During biosynthesis, collagen acquires a number of post-translational modifications, including lysine modifications, that are critical to the structure and biological functions of this protein. Lysine modifications of collagen are highly complicated sequential processes catalysed by several groups of enzymes leading to the

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28

Brooker, Charles, and Giuseppe Tronci. "Effect of Mammalian Tissue Source on the Molecular and Macroscopic Characteristics of UV-Cured Type I Collagen Hydrogel Networks." Prosthesis 4, no. 1 (2022): 1–14. http://dx.doi.org/10.3390/prosthesis4010001.

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The tissue source of type I collagen is critical to ensure scalability and regulation-friendly clinical translation of new medical device prototypes. However, the selection of a commercial source of collagen that fulfils both aforementioned requirements and is compliant with new manufacturing routes is challenging. This study investigates the effect that type I collagen extracted from three different mammalian tissues has on the molecular and macroscopic characteristics of a new UV-cured collagen hydrogel. Pepsin-solubilised bovine atelocollagen (BA) and pepsin-solubilised porcine atelocollage

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29

Eyre, David R., Stephen Apon, Jiann-Jiu Wu, Lowell H. Ericsson, and Kenneth A. Walsh. "Collagen type IX: Evidence for covalent linkages to type II collagen in cartilage." FEBS Letters 220, no. 2 (1987): 337–41. http://dx.doi.org/10.1016/0014-5793(87)80842-6.

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30

Yu, Le Tracy, and Jeffrey D. Hartgerink. "Selective covalent capture of collagen triple helices with a minimal protecting group strategy." Chemical Science 13, no. 9 (2022): 2789–96. http://dx.doi.org/10.1039/d1sc06361h.

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A minimal protecting group strategy is developed to allow selective covalent capture of collagen-like triple helices. This allows stabilization of this critical fold while preserving charge–pair interactions critical for biological applications.

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Hilderbrand, Amber M., Eden M. Ford, Chen Guo, Jennifer D. Sloppy, and April M. Kloxin. "Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture." Biomaterials Science 8, no. 5 (2020): 1256–69. http://dx.doi.org/10.1039/c9bm01894h.

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Synthetic multifunctional assembling peptides were designed to mimic the structure of collagen and allow independent control of hydrogel mechanical and biochemical properties through covalent crosslinking, enabling long-term in vitro 3D cell culture.

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32

Añazco, Carolina, Janin Riedelsberger, Lorenzo Vega-Montoto, and Armando Rojas. "Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis." International Journal of Molecular Sciences 24, no. 13 (2023): 10985. http://dx.doi.org/10.3390/ijms241310985.

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Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve complex enzymatic and non-enzymatic reactions. Lysyl oxidase (LOX) is responsible for catalyzing the oxidative deamination of lysine and hydroxylysine residues, resulting in the production of aldehydes, allysine, and hydroxyallysine. These intermediates undergo spontaneous condensation reactions, leading to the formation of immature cross-links,

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Wu, Yuexin, and Gaoxiang Ge. "Complexity of type IV collagens: from network assembly to function." Biological Chemistry 400, no. 5 (2019): 565–74. http://dx.doi.org/10.1515/hsz-2018-0317.

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Abstract Collagens form complex networks in the extracellular space that provide structural support and signaling cues to cells. Network-forming type IV collagens are the key structural components of basement membranes. In this review, we discuss how the complexity of type IV collagen networks is established, focusing on collagen α chain selection in type IV collagen protomer and network formation; covalent crosslinking in type IV collagen network stabilization; and the differences between solid-state type IV collagen in the extracellular matrix and soluble type IV collagen fragments. We furth

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Vadlamudi, R. K., R. J. McCormick, D. M. Medeiros, J. Vossoughi, and M. L. Failla. "Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves." American Journal of Physiology-Heart and Circulatory Physiology 264, no. 6 (1993): H2154—H2161. http://dx.doi.org/10.1152/ajpheart.1993.264.6.h2154.

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Dietary copper deficiency induces alterations of connective tissue metabolism that are associated with lesions in cardiovascular and other organ systems. To determine the impact of copper deficiency on characteristics of collagen in porcine myocardium and cardiac valves, weaned pigs were fed diets with adequate or deficient levels of copper. Although dietary copper did not affect the concentration of collagen in either myocardium or bicuspid valves, the degree of collagen cross-linking, as assessed by the level of hydroxylysylpyridinoline, was lower in both tissues of copper-deficient pigs. Pr

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35

González-Paz, Rodolfo J., Ana M. Ferreira, Clara Mattu, et al. "Cytocompatible polyurethanes from fatty acids through covalent immobilization of collagen." Reactive and Functional Polymers 73, no. 5 (2013): 690–97. http://dx.doi.org/10.1016/j.reactfunctpolym.2013.02.005.

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36

Koch, S., Ch Yao, G. Grieb, P. Prével, E. M. Noah, and G. C. M. Steffens. "Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF." Journal of Materials Science: Materials in Medicine 17, no. 8 (2006): 735–41. http://dx.doi.org/10.1007/s10856-006-9684-x.

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37

Keuren, Jeffrey F. W., Simone J. H. Wielders, Anita Driessen, Michel Verhoeven, Marc Hendriks, and Theo Lindhout. "Covalently-Bound Heparin Makes Collagen Thromboresistant." Arteriosclerosis, Thrombosis, and Vascular Biology 24, no. 3 (2004): 613–17. http://dx.doi.org/10.1161/01.atv.0000116026.18945.66.

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38

Sabeh, Farideh, Ryoko Shimizu-Hirota, and Stephen J. Weiss. "Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited." Journal of Cell Biology 185, no. 1 (2009): 11–19. http://dx.doi.org/10.1083/jcb.200807195.

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Tissue invasion during metastasis requires cancer cells to negotiate a stromal environment dominated by cross-linked networks of type I collagen. Although cancer cells are known to use proteinases to sever collagen networks and thus ease their passage through these barriers, migration across extracellular matrices has also been reported to occur by protease-independent mechanisms, whereby cells squeeze through collagen-lined pores by adopting an ameboid phenotype. We investigate these alternate models of motility here and demonstrate that cancer cells have an absolute requirement for the membr

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P., Khan, and P. Bhattacharyya S. "A constrained variational route to Pauling's electronegativity values†." Journal of Indian Chemical Society Vol. 80, May 2003 (2003): 521–25. https://doi.org/10.5281/zenodo.5839518.

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Department of Chemistry, Jogesh Chandra Chaudhuri College, 30 Prince Anwar Shah Road, Kolkata-700 033, India Deparatment of Physical Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700 032, India <em>E-mail :</em> pcspb@mahendra.iacs.res.in    Fax: 91-33-24732805 <em>Manuscript received 12 November 2002</em> Pauling's idea of estimating electronegativities of atoms by using bond-dissociation energy data and the idea of ionic-covalent resonance interaction are examined. Effective Hamiltonian for the perfectly covalent and perfectly ionic structures

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Crawford, S. W., R. P. Mecham, and H. Sage. "Structural characteristics and intermolecular organization of human pulmonary-surfactant-associated proteins." Biochemical Journal 240, no. 1 (1986): 107–14. http://dx.doi.org/10.1042/bj2400107.

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The structural relationships and intermolecular organization among the proteins associated with pulmonary surfactant are largely unknown. We studied the pulmonary-surfactant-associated proteins in the bronchoalveolar lavage fluid obtained from a patient with the clinical syndrome of alveolar proteinosis. The major proteins with Mr values of 32,000-36,000 and 62,000 formed thiol-dependent complexes (Mr greater than 400,000) with intermolecular disulphide bonds present in the collgenase-sensitive domains of these proteins. In contrast, other proteins, which were collagenase-insensitive, formed t

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Wieczorek, Andrew, Clara K. Chan, Suzana Kovacic, Cindy Li, Thomas Dierks, and Nancy R. Forde. "Genetically modified human type II collagen for N- and C-terminal covalent tagging." Canadian Journal of Chemistry 96, no. 2 (2018): 204–11. http://dx.doi.org/10.1139/cjc-2017-0335.

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Collagen is the predominant structural protein in vertebrates, where it contributes to connective tissues and the ECM; it is also widely used in biomaterials and tissue engineering. Dysfunction of this protein and its processing can lead to a wide variety of developmental disorders and connective tissue diseases. Recombinantly engineering the protein is challenging due to post-translational modifications generally required for its stability and secretion from cells. Introducing end labels into the protein is problematic, because the N- and C-termini of the physiologically relevant tropocollage

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Han, Ying, Jiaxun Li, Bobing He, and Lixin Li. "Preparation and characterization of a novel ACF-TpPa-1 composite for dye adsorption." Journal of Engineered Fibers and Fabrics 16 (January 2021): 155892502110158. http://dx.doi.org/10.1177/15589250211015898.

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Environmental challenges, especially dye wastewater produced by printing and dyeing industry, pose a serious threat to global public health, and it is an urgent problem to realize harmless treatment of dye wastewater. Here, the combination of covalent organic framework materials (TpPa-1) and biological matrix materials (CF) was explored for the adsorption of dyes for the first time. The functional ACF-TpPa-1 composite adsorption materials were successfully prepared with collagen fiber (CF) made of leather waste as matrix, ethylenediamine (EDA) and covalent organic framework material (TpPa-1) a

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43

Li, Baoe, Xuan Yong Liu, and Chuan Xian Ding. "Grafting Collagen on the Plasma Sprayed Titania Coating Treated by Sodium Hydroxide." Key Engineering Materials 330-332 (February 2007): 541–44. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.541.

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In this work, collagen type I was covalently grafted on the surface of plasma sprayed titania coatings to improve their biocompatibility. The plasma sprayed titania coatings were pretreated by sodium hydroxide to induce the formation of hydroxyl groups which can covalently graft collagen, rendering the collagen having good stability. The dependence of collagen grafting on the sodium hydroxide treatment conditions (concentration, time and temperature) was investigated by measuring the amount of collagen grafted on the titania surface. The biocompatibility of the titania coatings with grafted co

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44

Constantinescu, Mihai A., Alex Alfieri, George Mihalache, et al. "Effect of laser soldering irradiation on covalent bonds of pure collagen." Lasers in Medical Science 22, no. 1 (2006): 10–14. http://dx.doi.org/10.1007/s10103-006-0411-0.

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45

Bornstein, Paul. "Covalent cross-links in collagen: a personal account of their discovery." Matrix Biology 22, no. 5 (2003): 385–91. http://dx.doi.org/10.1016/s0945-053x(03)00061-1.

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Kent, M. J. C., N. D. Light, and A. J. Bailey. "Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro." Biochemical Journal 225, no. 3 (1985): 745–52. http://dx.doi.org/10.1042/bj2250745.

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Rabbit forelimb tendons incubated for 15 or 21 days at 35 degrees C in the presence of 8 or 24 mg of glucose/ml were shown to change their chemical, biochemical and mechanical characteristics. The tendons treated with glucose contained up to three times as much hexosyl-lysine and hexosylhydroxylysine as did control tendons as judged by assay of NaB3H4-reduced samples. Measurement of the force generated on thermal contraction showed significant increases in glycosylated tendons compared with controls, indicating the formation of new covalent stabilizing bonds. This conclusion was supported by t

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Choi, Sharon H., Rebecca L. Davis-Harrison, Stephanie A. Smith, Julie N. R. Collins, Chad M. Rienstra, and James H. Morrissey. "Covalent End-Labeling of Polyphosphate Facilitates Studies of Its Procoagulant Activities and Development of Enhanced Agents to Treat Bleeding." Blood 116, no. 21 (2010): 1138. http://dx.doi.org/10.1182/blood.v116.21.1138.1138.

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Abstract Abstract 1138 Introduction: Inorganic polyphosphates (polyP) are negatively charged, linear phosphate polymers that are abundant in platelet dense granules and secreted upon platelet activation. We recently reported that polyP may be the long-sought (patho)physiologic activator of the contact pathway with important roles in inflammation and thrombosis. We also reported that polyP opposes the action of many anticoagulant drugs and thus has potential as a general procoagulant agent to treat bleeding. Studies of the role of polyP in blood clotting would be facilitated by being able to co

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Agubata, Chukwuma O., Cynthia C. Mbaoji, Ifeanyi T. Nzekwe, César Saldías, and David Díaz Díaz. "Biohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications." Applied Sciences 11, no. 15 (2021): 6945. http://dx.doi.org/10.3390/app11156945.

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In this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, and derived composites, has been evaluated for wound healing applications. In particular, a phenylboronic acid–alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, and used to prepare varied concentrations of hydrogels and silicate-based nanocomposites in PBS. The resulting hydrogels were characterized in terms of interfacial tension, moisture uptake and loss, interaction with fresh acid-soluble collagen, self-healing ability, effects on blood clotting and wound healing. The

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Flowers, Brenna, Abigail Rullo, Pavel Petukhov, and Irida Kastrati. "Abstract 3042: Non-covalent thioredoxin reductase inhibitors for TNBC." Cancer Research 85, no. 8_Supplement_1 (2025): 3042. https://doi.org/10.1158/1538-7445.am2025-3042.

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Abstract Triple negative breast cancer (TNBC) has the lowest 5-year mortality and lacks targeted therapeutics. Therefore, there is a need to explore more therapeutic targets and strategies. Previous research has indicated that TXNRD1 may be a relevant target in other cancers and is elevated in TNBC and high levels of TXNRD1 and TXNRD2 correlate to lower recurrence free survival and lower overall survival (TXNRD1) and has emerged as a possible therapeutic target.The thioredoxin system includes thioredoxin reductase (TXNRD) and thioredoxin (Trx). TXNRD takes electrons from NADPH to reduce the di

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Zhao, Chenyu, Han Wang, Xue Sun, et al. "Non-Covalent Cross-Linking Hydrogel: A New Method for Visceral Hemostasis." Gels 10, no. 5 (2024): 326. http://dx.doi.org/10.3390/gels10050326.

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Excessive blood loss could lead to pathological conditions such as tissue necrosis, organ failure, and death. The limitations of recently developed hemostatic approaches, such as their low mechanical strength, inadequate wet tissue adhesion, and weak hemostatic activity, pose challenges for their application in controlling visceral bleeding. In this study, a novel hydrogel (CT) made of collagen and tannic acid (TA) was proposed. By altering the proportions between the two materials, the mechanical properties, adhesion, and coagulation ability were evaluated. Compared to commercial hydrogels, t

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