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Journal articles on the topic 'Collagen complex reviews'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Bykanov, Aleksandr S., and Elena S. Snarskaya. "Microneedling in the threatment of post-acne symptom complex." Russian Journal of Skin and Venereal Diseases 24, no. 1 (2021): 79–92. http://dx.doi.org/10.17816/dv62216.

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The review presents data from foreign and domestic clinical studies on the efficacy and safety of microneedling application in the treatment of post-acne symptom complex. An analysis of the database of systematic reviews of Russian, European, American researchers, comparative studies on the effectiveness of the microneedling therapy in patients with different skin types for the treatment of postacne symptom complex is presented. Possibilities of microneedling monotherapy and variants of combined treatment, in particular the combinations of microneedling with PRP-therapy, acid peels, non-ablati

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Quinlan, Catherine, and Michelle N. Rheault. "Genetic Basis of Type IV Collagen Disorders of the Kidney." Clinical Journal of the American Society of Nephrology 16, no. 7 (2021): 1101–9. http://dx.doi.org/10.2215/cjn.19171220.

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The glomerular basement membrane is a vital component of the filtration barrier of the kidney and is primarily composed of a highly structured matrix of type IV collagen. Specific isoforms of type IV collagen, the α3(IV), α4(IV), and α5(IV) isoforms, assemble into trimers that are required for normal glomerular basement membrane function. Disruption or alteration in these isoforms leads to breakdown of the glomerular basement membrane structure and function and can lead to progressive CKD known as Alport syndrome. However, there is wide variability in phenotype among patients with mutations af

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Sitoresmi, Anak Agung Istri Ajeng, Maria Pramesthi Sabrina Evananda, and Anak Agung Gde Ngurah Asmarajaya. "Encapsulation of Adipose-Derived Stem Cells in Collagen-Based Hydrogel." Annals of Plastic Surgery 95, no. 1 (2025): 111–18. https://doi.org/10.1097/sap.0000000000004418.

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Introduction Skin graft is still the major treatment for burn injuries, despite its high risk of visible scarring which raises concerns regarding aesthetics and patient quality of life. This study proposes the usage of adipose-derived stem cells encapsulated in type I collagen-based hydrogel as a promoter to enhance wound healing, replace skin, and perfect skin regeneration. One of the potential tools for reconstructive surgery, regenerative treatments, and aesthetic enhancements due to their safety, efficiency, and cost-effectiveness is adipose-derived stem cells. Methods This review study us

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Watson, Steve. "Collagen Receptor Signaling in Platelets and Megakaryocytes." Thrombosis and Haemostasis 82, no. 08 (1999): 365–76. http://dx.doi.org/10.1055/s-0037-1615855.

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IntroductionThe extracellular matrix protein, collagen, plays a primary role in hemostasis. Collagen fibers provide an important site for adhesion of platelets to the exposed subendothelium, trapping them at the site of vascular damage and enabling the formation of a monolayer of cells over the damaged area. Collagen fibers also stimulate platelet activation, leading to inside-out regulation of the integrin glycoprotein (GP) IIb-IIIa (also known as αIIbβ3), secretion from dense and α granules, generation of thromboxanes, and expression of procoagulant activity, all of which support the hemosta

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Matencio, Adrián, Fabrizio Caldera, Claudio Cecone, José Manuel López-Nicolás, and Francesco Trotta. "Cyclic Oligosaccharides as Active Drugs, an Updated Review." Pharmaceuticals 13, no. 10 (2020): 281. http://dx.doi.org/10.3390/ph13100281.

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There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-based materials used for drug delivery, but the capacity of CDs to complex different agents and their own intrinsic properties suggest they might also be considered for use as active drugs, not only as carriers. The aim of this review is to summarize the direct use of CDs as drugs, without using its complexing potential with other substances. The direct application of another oligosaccharide called cyclic nigerosyl-1,6-nigerose (CNN) is also described. The review is divided into lipid-related diseases, aggregat

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McDonald, J. A. "Receptors for extracellular matrix components." American Journal of Physiology-Lung Cellular and Molecular Physiology 257, no. 6 (1989): L331—L337. http://dx.doi.org/10.1152/ajplung.1989.257.6.l331.

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The extracellular matrix determines the shape and function of multicellular organisms and permits orderly repair after injury. Although the inherent self-assembly properties of many extracellular matrix components such as collagen and elastin foster their deposition and supramolecular organization, cells ultimately dictate the location and composition of regional matrices. These matrices in turn communicate with cells and regulate their attachment, movement, growth, and gene expression. This complex interaction between cells and their matrix is mediated via specific cellular receptors for matr

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Wells, Hannah J., Jenny C. C. Yang, Leah Edelstein-Keshet, and Kathryn V. Isaac. "Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways." Plastic and Reconstructive Surgery - Global Open 12, no. 5 (2024): e5802. http://dx.doi.org/10.1097/gox.0000000000005802.

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Background: Capsular contracture (CC) is a leading cause of morbidity in implant-based breast surgery. Implant surface texture has been implicated in CC development, yet its etiopathogenesis remains unclear. We conducted a systematic review to determine the influence of implant surface texture on cellular and molecular mechanisms involved in the etiopathogenesis of CC. Methods: A systematic review of the MEDLINE, Embase, Web of Science, and Scopus databases was completed to examine the influence of implant texture on cellular and molecular pathways leading to CC. Excluded articles were reviews

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Bondar', I. A., and V. V. Klimontov. "Glycosaminoglycans and diabetic nephropathy." Problems of Endocrinology 50, no. 2 (2004): 29–34. http://dx.doi.org/10.14341/probl11392.

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Diabetic nephropathy (DN) is one of the leading places in the structure of mortality of patients with diabetes mellitus (DM) in Russia and abroad. Despite intensive study, the causes and development mechanisms of this complication are not finally clear. Most often, diabetic kidney damage is seen as the result of a complex interaction of metabolic, hemodynamic, genetic and other mechanisms. At the same time, the majority of researchers give the leading role to hyperglycemia and the metabolic disorders triggered by it. The latter include intensification of non-enzymatic glycation processes, acti

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Berjano, Enrique J., Enrique Navarro, Vicente Ribera, Javier Gorris, and Jorge L. Alió. "Radiofrequency Heating of the Cornea: An Engineering Review of Electrodes and Applicators." Open Biomedical Engineering Journal 1, no. 1 (2007): 71–76. http://dx.doi.org/10.2174/1874120700701010071.

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This paper reviews the different applicators and electrodes employed to create localized heating in the cornea by means of the application of radiofrequency (RF) currents. Thermokeratoplasty (TKP) is probably the best known of these techniques and is based on the principle that heating corneal tissue (particularly the central part of the corneal tissue, i.e. the central stroma) causes collagen to shrink, and hence changes the corneal curvature. Firstly, we point out that TKP techniques are a complex challenge from the engineering point of view, due to the fact that it is necessary to create ve

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Wu, Yuexin, and Gaoxiang Ge. "Complexity of type IV collagens: from network assembly to function." Biological Chemistry 400, no. 5 (2019): 565–74. http://dx.doi.org/10.1515/hsz-2018-0317.

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Abstract Collagens form complex networks in the extracellular space that provide structural support and signaling cues to cells. Network-forming type IV collagens are the key structural components of basement membranes. In this review, we discuss how the complexity of type IV collagen networks is established, focusing on collagen α chain selection in type IV collagen protomer and network formation; covalent crosslinking in type IV collagen network stabilization; and the differences between solid-state type IV collagen in the extracellular matrix and soluble type IV collagen fragments. We furth

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Wolosowicz, Marta, Slawomir Prokopiuk, and Tomasz W. Kaminski. "The Complex Role of Matrix Metalloproteinase-2 (MMP-2) in Health and Disease." International Journal of Molecular Sciences 25, no. 24 (2024): 13691. https://doi.org/10.3390/ijms252413691.

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Matrix metalloproteinase-2 (MMP-2), a zinc-dependent enzyme, plays a critical role in the degradation and remodeling of the extracellular matrix (ECM). As a member of the gelatinase subgroup of matrix metalloproteinases, MMP-2 is involved in a variety of physiological processes, including tissue repair, wound healing, angiogenesis, and embryogenesis. It is primarily responsible for the degradation of type IV and V collagen, fibronectin, laminin, and elastin, which are essential components of the ECM. MMP-2 is secreted as an inactive pro-enzyme (proMMP-2) and activated through proteolytic cleav

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Rappu, Pekka, Antti M. Salo, Johanna Myllyharju, and Jyrki Heino. "Role of prolyl hydroxylation in the molecular interactions of collagens." Essays in Biochemistry 63, no. 3 (2019): 325–35. http://dx.doi.org/10.1042/ebc20180053.

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Abstract Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-hydroxylases and collagen prolyl 3-hydroxylases, the enzymes responsible for proline hydroxylation. Furthermore, we describe the potential roles of hydroxyproline residues in the complex interplay between collagens and other proteins, especially integrin and discoidin domain receptor type cell adhesion receptors. Qualitative and quantitative regulation of collagen hydroxylation may have remark

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Ledwoń, Patrycja, Anna Maria Papini, Paolo Rovero, and Rafal Latajka. "Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation." Materials 14, no. 12 (2021): 3217. http://dx.doi.org/10.3390/ma14123217.

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Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibrotic process and collagen accumulation results with joints, bone, heart, lungs, kidneys or liver fibroses. Per contra, dysfunctional collagen turnover and its increased degradation leads to wound healing disruption, skin photoaging, and loss of firmness and elasticity. In this review we described th

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Song, Kena, Zhangqing Yu, Xiangyang Zu, Guoqiang Li, Zhigang Hu, and Yun Xue. "Collagen Remodeling along Cancer Progression Providing a Novel Opportunity for Cancer Diagnosis and Treatment." International Journal of Molecular Sciences 23, no. 18 (2022): 10509. http://dx.doi.org/10.3390/ijms231810509.

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The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the main component of the ECM, are greatly remodeled alongside cancer development. More and more studies have confirmed that collagens changed from a barrier to providing assistance in cancer development. In this course, collagens cause remodeling alongside cancer progression, which in turn, promotes cancer development. The interaction between collagens and tumor cells is complex with biochemical and mechanical signals intervention through activating diverse signal pathways. As the mechanism gradually c

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Potekaev, Nikolay N., Olga B. Borzykh, German V. Medvedev, et al. "Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning." Cosmetics 8, no. 4 (2021): 92. http://dx.doi.org/10.3390/cosmetics8040092.

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One of the most important functions of the skin, i.e., protection from mechanical damage, is ensured by collagen fibers and their interaction with other elements in the extracellular matrix. Collagen fiber turnover is a complex multi-stage process. At each stage, a disruption may occur, leading to a decrease in the mechanical properties of the connective tissue. Clinically, collagen formation disorders manifest themselves as increased flabbiness and looseness of the skin and as early signs of facial aging. In addition to the clinical picture, it is important for cosmetologists and dermatologis

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Bella, Jordi. "Collagen structure: new tricks from a very old dog." Biochemical Journal 473, no. 8 (2016): 1001–25. http://dx.doi.org/10.1042/bj20151169.

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The main features of the triple helical structure of collagen were deduced in the mid-1950s from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average description of the molecular conformation. A critical advance came about 20 years later with the chemical synthesis of sufficiently long and homogeneous peptides with collagen-like sequences. The availability of these collagen model peptides resulted in a large number of biochemical, crystallographic and NMR studies that have revolutionized our understanding of collagen structure. High-resolution crystal struc

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Tavares, Ana, Luísa Olivença, and Marisa Vilas Boas. "Nursing care in the prevention of skin tears in the elderly: integrative review of the literature." Pensar Enfermagem - Revista Científica | Journal of Nursing 27, no. 1 (2023): 43–53. http://dx.doi.org/10.56732/pensarenf.v27i1.214.

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Introduction Skin tears are considered injuries of traumatic etiology that can result from a variety of mechanical forces, such as shear or friction forces, blunt trauma, falls, improper handling, injury caused by equipment or removal of adherent dressings. These are acute wounds that have a high probability of becoming complex chronic wounds. They cause pain, increase healthcare costs, reduce quality of life and are a source of stress for the person. They lengthen hospital stay and increase the risk of morbidities. Skin Tears are a growing problem, making it crucial to invest in this topic in

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Tavares, Ana Carina, Luísa Olivença, Marisa Vilas Boas, and Sandra Queirós. "Correction: Nursing care in the prevention of skin tears in the elderly: integrative review of the literature." Pensar Enfermagem - Revista Científica | Journal of Nursing 28, no. 1 (2024): 50–60. http://dx.doi.org/10.56732/pensarenf.v28i1.327.

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Introduction Skin tears are considered injuries of traumatic etiology that can result from a variety of mechanical forces, such as shear or friction forces, blunt trauma, falls, improper handling, injury caused by equipment or removal of adherent dressings. These are acute wounds that have a high probability of becoming complex chronic wounds. They cause pain, increase healthcare costs, reduce quality of life and are a source of stress for the person. They lengthen hospital stay and increase the risk of morbidities. Skin Tears are a growing problem, making it crucial to invest in this topic in

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Chiarelli, Ritelli, Zoppi, and Colombi. "Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes." Genes 10, no. 8 (2019): 609. http://dx.doi.org/10.3390/genes10080609.

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The Ehlers‒Danlos syndromes (EDS) constitute a heterogenous group of connective tissue disorders characterized by joint hypermobility, skin abnormalities, and vascular fragility. The latest nosology recognizes 13 types caused by pathogenic variants in genes encoding collagens and other molecules involved in collagen processing and extracellular matrix (ECM) biology. Classical (cEDS), vascular (vEDS), and hypermobile (hEDS) EDS are the most frequent types. cEDS and vEDS are caused respectively by defects in collagen V and collagen III, whereas the molecular basis of hEDS is unknown. For these d

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Necula, Laura, Lilia Matei, Denisa Dragu, et al. "Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer." International Journal of Molecular Sciences 23, no. 20 (2022): 12415. http://dx.doi.org/10.3390/ijms232012415.

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Despite advances in cancer detection and therapy, it has been estimated that the incidence of cancers will increase, while the mortality rate will continue to remain high, a fact explained by the large number of patients diagnosed in advanced stages when therapy is often useless. Therefore, it is necessary to invest knowledge and resources in the development of new non-invasive biomarkers for the early detection of cancer and new therapeutic targets for better health management. In this review, we provided an overview on the collagen family as promising biomarkers and on how they may be exploi

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Zaitsev, Sergei Y. "Amino acid composition of gelatins from various bovine collagens." Veterinariya, Zootekhniya i Biotekhnologiya 6, no. 115 (2023): 119–29. http://dx.doi.org/10.36871/vet.zoo.bio.202306015.

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The amino acid composition of gelatins, as well as their other properties, varies significantly depending on the sources and types of initial collagens and a number of technological conditions for their production. On the other hand, the amino acid composition of gelatins is one of the important indicators characterizing the quality of these intermediates, which consist of a number of peptide substances. According to the author, gelatin is a polypeptide product of the hydrolysis of the original protein – animal collagen. This complex definition is a combination of a number of known gelatin def

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Fu, Yi, Yuan Zhou, Kai Wang, Zhuofan Li, and Wei Kong. "Extracellular Matrix Interactome in Modulating Vascular Homeostasis and Remodeling." Circulation Research 134, no. 7 (2024): 931–49. http://dx.doi.org/10.1161/circresaha.123.324055.

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The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively. In addition, extracellular pro

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Kumar, Rahul, Kiran Marla, Kyle Sporn, et al. "Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment." Diagnostics 15, no. 13 (2025): 1648. https://doi.org/10.3390/diagnostics15131648.

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Musculoskeletal (MSK) disorders remain a major global cause of disability, with diagnostic complexity arising from their heterogeneous presentation and multifactorial pathophysiology. Recent advances across imaging modalities, molecular biomarkers, artificial intelligence applications, and point-of-care technologies are fundamentally reshaping musculoskeletal diagnostics. This review offers a novel synthesis by unifying recent innovations across multiple diagnostic imaging modalities, such as CT, MRI, and ultrasound, with emerging biochemical, genetic, and digital technologies. While existing

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Goldstein, R. H. "Control of type I collagen formation in the lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 261, no. 2 (1991): L29—L40. http://dx.doi.org/10.1152/ajplung.1991.261.2.l29.

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Type I collagen is a major structural protein in the lung, the accumulation of which is stimulated during certain inflammatory reactions in the lung. Accumulating evidence suggests that type I collagen formation parallels changes in steady-state mRNA levels. Specific inflammatory substances modulate transcription of collagen genes and stabilization of collagen mRNA in vitro. However, the precise role for any particular mediator during fibrotic processes is difficult to identify because of the complex nature of the inflammatory reaction and potential interaction among mediators. The signal tran

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Sarychev, Leonid, and Roman Savchenko. "Bladder Decompensation in Patients with Benign Prostatic Hyperplasia: Causes, Complications, Rehabilitation." Health of Man, no. 4 (December 30, 2021): 111–18. http://dx.doi.org/10.30841/2307-5090.4.2021.252411.

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Background Despite the high efficiency of surgical methods in correction of bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH), a significant proportion of patients (up to 35%) remains after surgery with impaired contractile function of the bladder and lower urinary tract symptoms (LUTS). Both are consequences of structural and functional changes of the detrusor due to long-term exposure to obstructive factor. Today there is a lack of systematic reviews that provide a specialist with an integrative conception of pathological changes in the bladder wall caused by BPH

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Sarychev, Leonid, and Roman Savchenko. "Bladder Decompensation in Patients with Benign Prostatic Hyperplasia: Causes, Complications, Rehabilitation." Health of Man, no. 4 (December 30, 2021): 111–18. https://doi.org/10.30841/2307-5090.4.2021.252411.

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Background Despite the high efficiency of surgical methods in correction of bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH), a significant proportion of patients (up to 35%) remains after surgery with impaired contractile function of the bladder and lower urinary tract symptoms (LUTS). Both are consequences of structural and functional changes of the detrusor due to long-term exposure to obstructive factor. Today there is a lack of systematic reviews that provide a specialist with an integrative conception of pathological changes in the bladder wall caused by BPH

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Carr, Benjamin P., Zhi Chen, Johnson H. Y. Chung, and Gordon G. Wallace. "Collagen Alignment via Electro-Compaction for Biofabrication Applications: A Review." Polymers 14, no. 20 (2022): 4270. http://dx.doi.org/10.3390/polym14204270.

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As the most prevalent structural protein in the extracellular matrix, collagen has been extensively investigated for biofabrication-based applications. However, its utilisation has been impeded due to a lack of sufficient mechanical toughness and the inability of the scaffold to mimic complex natural tissues. The anisotropic alignment of collagen fibres has been proven to be an effective method to enhance its overall mechanical properties and produce biomimetic scaffolds. This review introduces the complicated scenario of collagen structure, fibril arrangement, type, function, and in addition,

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Potekaev, N. N., O. B. Borzykh, N. A. Shnayder, M. M. Petrova, E. I. Karpova, and R. F. Nasyrova. "Collagen synthesis in the skin: genetic and epigenetic aspects." Bulletin of Siberian Medicine 21, no. 3 (2022): 217–26. http://dx.doi.org/10.20538/1682-0363-2022-3-217-226.

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One of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease in the mechanical properties of the connective tissue. In clinical practice, disorders of collagen synthesis are manifested through increased skin laxity and looseness and premature aging. In addition to the clinical presentation, it is important for the cosmetologist and dermatologist to understand

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Rodríguez, Cristina, and José Martínez-González. "The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling." Cells 8, no. 12 (2019): 1483. http://dx.doi.org/10.3390/cells8121483.

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Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary covalent cross-linkages. Therefore, they are essential for the synthesis of a mature ECM and assure matrix integrity. ECM modulates cellular phenotype and

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McKleroy, William, Ting-Hein Lee, and Kamran Atabai. "Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 11 (2013): L709—L721. http://dx.doi.org/10.1152/ajplung.00418.2012.

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Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options. In the normal lung there is continuous collagen synthesis and collagen degradation, and these two processes are precisely balanced to maintain normal tissue architecture. With lung injury there is an increase in the rate of both collagen production and collagen degradation. The increase in collagen degradation is critical in preventing the formation of permanent scar tissue each time the lung is exposed to injury. In pulmonary fibrosis, collagen degradation does not keep pace with collagen production, resulting

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Nieswandt, Bernhard, and Steve P. Watson. "Platelet-collagen interaction: is GPVI the central receptor?" Blood 102, no. 2 (2003): 449–61. http://dx.doi.org/10.1182/blood-2002-12-3882.

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AbstractAt sites of vascular injury, platelets come into contact with subendothelial collagen, which triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib (GPIb) and αIIbβ3 integrin, which indirectly interact with collagen via von Willebrand factor (VWF), several collagen receptors have been identified on platelets, most notably α2β1 integrin and the immunoglobulin (Ig) superfamily member GPVI. Within the last few years, major advances have been made in understanding platelet-collagen interactions including the molecular cloning of GPVI, the generation of mo

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Nikolov, Asparuh, Nikola Popovski, and Irena Hristova. "Collagenases MMP-1, MMP-13, and Tissue Inhibitors TIMP-1, TIMP-2: Their Role in Healthy and Complicated Pregnancy and Potential as Preeclampsia Biomarkers—A Brief Review." Applied Sciences 10, no. 21 (2020): 7731. http://dx.doi.org/10.3390/app10217731.

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Extracellular matrix (ECM) turnover is characterized by a unique balance between matrix metalloproteinases’ degradation activity and their natural inhibition by collagen specific tissue inhibitors. Human uterine ECM is a complex structure, majorly consisting of proteins as fibrillar collagen types I and III, fibronectin, and laminin. Collagenases are enzymes from the matrix metalloproteinases’ family, which are predominantly involved in fibrillar collagen types I and III degradation. They are mainly represented by matrix metalloproteinase-1, -13 (MMP-1, -13), naturally inhibited by tissue inhi

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Pallaske, Frank, Anett Pallaske, Kurt Herklotz, and Joachim Boese-Landgraf. "The significance of collagen dressings in wound management: a review." Journal of Wound Care 27, no. 10 (2018): 692–702. http://dx.doi.org/10.12968/jowc.2018.27.10.692.

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Clinical experience and research has improved our understanding of wound healing which, in turn, has enabled health professionals to aid wound healing and manufacturers to develop modern wound dressings. The significant role of collagen in wound healing has led to the development of numerous products on the basis of this biological material. The main focus of this review is to provide a critical appraisal of publications about collagen and acellular collagen dressings with a fleece-like or spongy structure. It is intended for clinicians and researchers, and aims to keep them up-to-date in the

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Añazco, Carolina, Janin Riedelsberger, Lorenzo Vega-Montoto, and Armando Rojas. "Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis." International Journal of Molecular Sciences 24, no. 13 (2023): 10985. http://dx.doi.org/10.3390/ijms241310985.

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Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve complex enzymatic and non-enzymatic reactions. Lysyl oxidase (LOX) is responsible for catalyzing the oxidative deamination of lysine and hydroxylysine residues, resulting in the production of aldehydes, allysine, and hydroxyallysine. These intermediates undergo spontaneous condensation reactions, leading to the formation of immature cross-links,

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Claeys, Lauria, Silvia Storoni, Marelise Eekhoff, et al. "Collagen transport and related pathways in Osteogenesis Imperfecta." Human Genetics 140, no. 8 (2021): 1121–41. http://dx.doi.org/10.1007/s00439-021-02302-2.

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AbstractOsteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone fragility and deformities as the main characteristics, albeit with different degrees of severity. Phenotypic variation also exists in other connective tissue aspects of the disease, complicating disease classification and disease course prediction. Although collagen type I defects are long established as the primary cause of the bone pathology, we are still far from comprehending the complete mechanism. In the last years, the advent of next generation sequencing has triggered the discovery of many n

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Mereddy, Rishith R., Emily E. Zona, Camille J. LaLiberte, and Aaron M. Dingle. "Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review." Journal of Functional Biomaterials 16, no. 3 (2025): 97. https://doi.org/10.3390/jfb16030097.

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Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including

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Prasetia, Renaldi, Siti Zainab Bani Purwana, and Hermawan Nagar Rasyid. "Multidirectional Instability of Shoulder Joint: A Review." Orthopaedic Journal of Sports Medicine 11, no. 2_suppl (2023): 2325967121S0083. http://dx.doi.org/10.1177/2325967121s00838.

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Introduction: The biomechanics of the shoulder joint are complex. To allow a functional range of motion, stability is sacrificed. Glenohumeral joint stability is maintained by static and dynamic stabilizers. Static stabilizers are non-contractile structures including capsulolabral structures and bony glenoid while dynamic stabilizers are contractile structures including rotator cuff, conjoint tendon, and long head of the bicep. The objective of this review is to elaborate on multidirectional instability (MDI) of the shoulder joint and the management of this disorder. Review: Laxity can be affe

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Cardona-Timoner, Maria, Rita N. Gomes, and Diana S. Nascimento. "Dressed in Collagen: 2D and 3D Cardiac Fibrosis Models." International Journal of Molecular Sciences 26, no. 7 (2025): 3038. https://doi.org/10.3390/ijms26073038.

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Cardiovascular diseases (CVD), the leading cause of death worldwide, and their strong association with fibrosis highlight the pressing need for innovative antifibrotic therapies. In vitro models have emerged as valuable tools for replicating cardiac fibrosis ‘in a dish’, facilitating the study of disease mechanisms and serving as platforms for drug testing and development. These in vitro systems encompass 2D and 3D models, each with its own limitations and advantages. 2D models offer high reproducibility, cost-effectiveness, and high-throughput capabilities, but they oversimplify the complex f

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Hulmes, David J. S. "Roles of the procollagen C-propeptides in health and disease." Essays in Biochemistry 63, no. 3 (2019): 313–23. http://dx.doi.org/10.1042/ebc20180049.

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AbstractThe procollagen C-propeptides of the fibrillar collagens play key roles in the intracellular assembly of procollagen molecules from their constituent polypeptides chains, and in the extracellular assembly of collagen molecules into fibrils. Here we review recent advances in understanding the molecular mechanisms controlling C-propeptide trimerization which have revealed the importance of inter-chain disulphide bonding and a small number of charged amino acids in the stability and specificity of different types of chain association. We also show how the crystal structure of the complex

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Dydykina, I. S., P. S. Kovalenko, A. A. Kovalenko, and A. V. Aboleshina. "The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints." Meditsinskiy sovet = Medical Council, no. 14 (August 12, 2022): 145–53. http://dx.doi.org/10.21518/2079-701x-2022-16-14-145-153.

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Among the proteins of the human body, collagen accounts for at least 25–45% collagen; it is an essential structural component of skeletal tissues, connective tissue of internal organs (heart, intestines, lungs, liver, kidneys), as well as blood vessels. The variety of types of collagen is due to their role and function. The article presents information about the structure and synthesis of collagen, a high concentration of glycine, proline and hydroxyproline in the alpha chains of the collagen helix. Attention is drawn to the fact that cross-links and orientation of collagen fibers in the direc

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Yang, Bo, Yan Qiao, Dong Yan, and Qinghang Meng. "Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis." Cells 13, no. 9 (2024): 764. http://dx.doi.org/10.3390/cells13090764.

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Excessive extracellular matrix (ECM) deposition is a defining feature of cardiac fibrosis. Most notably, it is characterized by a significant change in the concentration and volume fraction of collagen I, a disproportionate deposition of collagen subtypes, and a disturbed ECM network arrangement, which directly affect the systolic and diastolic functions of the heart. Immune cells that reside within or infiltrate the myocardium, including macrophages, play important roles in fibroblast activation and consequent ECM remodeling. Through both direct and indirect connections to fibroblasts, monocy

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Ulian, Gianfranco, Daniele Moro, and Giovanni Valdrè. "Hydroxylapatite and Related Minerals in Bone and Dental Tissues: Structural, Spectroscopic and Mechanical Properties from a Computational Perspective." Biomolecules 11, no. 5 (2021): 728. http://dx.doi.org/10.3390/biom11050728.

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Hard tissues (e.g., bone, enamel, dentin) in vertebrates perform various and different functions, from sustaining the body to haematopoiesis. Such complex and hierarchal tissue is actually a material composite whose static and dynamic properties are controlled by the subtle physical and chemical interplay between its components, collagen (main organic part) and hydroxylapatite-like mineral. The knowledge needed to fully understand the properties of bony and dental tissues and to develop specific applicative biomaterials (e.g., fillers, prosthetics, scaffolds, implants, etc.) resides mostly at

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Jain, Karun, Apurv A. Mehra, Kapil D. Mehta, Lyndon L. Dsouza, and Ratna Kumar. "Role of undenatured collagen type II and Aflapin combination in the management of osteoarthritis: a review." International Journal of Research in Orthopaedics 7, no. 4 (2021): 885. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20212441.

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<p class="abstract">Osteoarthritis (OA) is the most common joint disease affecting millions worldwide. Osteoarthritis typically affects the knees, hands, hips, and feet. It is characterized by complex pathologic changes in cartilage which haven’t been fully elucidated yet. However, recent research has shown the involvement of two contributing pathways namely the mechanical and the immune pathways which interlink to cause cartilage destruction. Patients with OA on current treatment options still inevitably progress to a more severe stage becoming candidates for total joint replacement. Th

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Majo, Sandra, and Patrick Auguste. "The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development." Cancers 13, no. 7 (2021): 1725. http://dx.doi.org/10.3390/cancers13071725.

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The tumor microenvironment is a complex structure composed of the extracellular matrix (ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune cells). Collagens are the main components of the ECM and they are extensively remodeled during tumor progression. Some collagens are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. DDRs are involved in different stages of tumor development and metastasis formation. In this review, we present the different roles of DDRs in these processes and discuss controversial findings. We conclude by describing

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Cascarino, Marine, and Stéphanie Leclerc-Mercier. "Histological Patterns of Skin Lesions in Tuberous Sclerosis Complex: A Panorama." Dermatopathology 8, no. 3 (2021): 236–52. http://dx.doi.org/10.3390/dermatopathology8030029.

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Tuberous Sclerosis Complex (TSC) is a multisystem genetic disease characterized by cutaneous and extracutaneous hamartomas. The diagnosis is based on the association of major and minor criteria, defined by a consensus conference updated in 2012. The clinical examination of the skin is crucial because seven diagnostic criteria are dermatological: four major (hypomelanotic macules, angiofibroma or fibrous cephalic plaques, ungual fibromas, shagreen patches) and three minor criteria (confetti skin lesions, dental enamel pits, intraoral fibromas). Skin biopsy is commonly performed to assert the di

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Abel, Richard L., Richard Stavri, Marena Gray, and Ulrich Hansen. "Clinical Importance of Bone Matrix Damage Mechanisms for Fracture Prevention." Current Osteoporosis Reports 19, no. 3 (2021): 318–26. http://dx.doi.org/10.1007/s11914-021-00678-8.

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Abstract Purpose of Review Bone matrix exhibits great complexity in its composition, structure and mechanics. Here, we provide a review of recent research articles and appraise the evidence that bone matrix quality is clinically important and possibly targetable for fracture prevention. Recent Findings Deformation of mineralised collagen fibrils determines bone fracture mechanics. Slipping and separation at the mineral-fibril and fibril-fibril interfaces, respectively, are the structural mechanisms for plastic deformation and microcrack nucleation. Existing technologies for assessing bone tiss

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Suki, Béla, Satoru Ito, Dimitrije Stamenović, Kenneth R. Lutchen, and Edward P. Ingenito. "Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces." Journal of Applied Physiology 98, no. 5 (2005): 1892–99. http://dx.doi.org/10.1152/japplphysiol.01087.2004.

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The biomechanical properties of connective tissues play fundamental roles in how mechanical interactions of the body with its environment produce physical forces at the cellular level. It is now recognized that mechanical interactions between cells and the extracellular matrix (ECM) have major regulatory effects on cellular physiology and cell-cycle kinetics that can lead to the reorganization and remodeling of the ECM. The connective tissues are composed of cells and the ECM, which includes water and a variety of biological macromolecules. The macromolecules that are most important in determi

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Salvatore, Luca, Maria Lucia Natali, Chiara Brunetti, Alessandro Sannino, and Nunzia Gallo. "An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications." Polymers 15, no. 4 (2023): 1020. http://dx.doi.org/10.3390/polym15041020.

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Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strat

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Bonanni, Alice, Ramona Vinci, Alessia d’Aiello, et al. "Targeting Collagen Pathways as an HFpEF Therapeutic Strategy." Journal of Clinical Medicine 12, no. 18 (2023): 5862. http://dx.doi.org/10.3390/jcm12185862.

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Heart failure with preserved ejection fraction (HFpEF) is a complex and heterogeneous clinical syndrome. The prevalence is expected to increase in the coming years, resulting in heart failure with reduced ejection fraction (HFrEF). This condition poses a burden to the global health care system as the number of patients affected by this condition is constantly increasing due to a rising average lifespan. The absence of validated drugs effective in reducing hospitalization rates and mortality may reflect the impossibility of applying a one size fits all approach as in HFrEF, heading for a person

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Peall, Ian W., Rachel K. Okolicsanyi, Lyn R. Griffiths, and Larisa M. Haupt. "Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche." Seminars in Thrombosis and Hemostasis 47, no. 03 (2021): 308–15. http://dx.doi.org/10.1055/s-0041-1724117.

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AbstractHeparan sulfate proteoglycans (HSPGs) are a diverse family of polysaccharides, consisting of a core protein with glycosaminoglycan (GAG) side chains attached. The heterogeneous GAG side-chain carbohydrates consist of repeating disaccharides, with each side chain possessing a specific sulfation pattern. It is the variable sulfation pattern that allows HSPGs to interact with numerous ligands including growth factors, cytokines, chemokines, morphogens, extracellular matrix (ECM) glycoproteins, collagens, enzymes, and lipases. HSPGs are classified according to their localization within an

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