Relevant bibliographies by topics / Collagen mutants

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Collagen mutants'

Author: Grafiati
Published: 6 September 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Collagen mutants.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Collagen mutants"

1

McKinnon, Thomas A. J., Agata Anna Nowak, Alina Hua, Carolyn Millar, and Michael Laffan. "Flow Analysis of Von Willebrand Factor Collagen Binding Mutants." Blood 118, no. 21 (2011): 2213. http://dx.doi.org/10.1182/blood.v118.21.2213.2213.

Full text
Abstract:
Abstract Abstract 2213 Von Willebrand Factor (VWF) binds to exposed sub-endothelial collagen at sites of vessel injury principally via its A3 domain, although some evidence suggests that the A1 domain can compensate for the A3 domain under flow conditions if the A3 domain is absent or non-functional. Recently, several naturally occurring Von Willebrand disease-causing mutations have been indentified in the A3 domain; S1731T, W1745C, S1783, H1786D and most recently M1761K, as well as one mutation in the A1 domain (I1343V) all of which have defective collagen binding. While the collagen binding
APA, Harvard, Vancouver, ISO, and other styles
2

Shida, Yasuaki, Christine Brown, Jeff Mewburn, et al. "Comprehensive In Vitro and In Vivo Characterization of Loss and Gain-of-Function Von Willebrand Factor Collagen Binding Variants Using a Mouse Model System,." Blood 118, no. 21 (2011): 3266. http://dx.doi.org/10.1182/blood.v118.21.3266.3266.

Full text
Abstract:
Abstract Abstract 3266 Von Willebrand Factor (VWF) is a large multimeric glycoprotein that mediates platelet adhesion to the damaged blood vessel wall and subsequent platelet aggregation at the site of injury. Rare mutations in the VWF A3 domain, that disrupt collagen binding, have been found in patients with a mild bleeding phenotype. However, the analysis of these aberrant VWF-collagen interactions has been relatively limited. Thus, in this study, we have developed mouse models of collagen binding mutants and analyzed the function of the A3 and A1 domains using comprehensive in vitro and in
APA, Harvard, Vancouver, ISO, and other styles
3

Shitomi, Yasuyuki, Ida B. Thøgersen, Noriko Ito, Birgit Leitinger, Jan J. Enghild, and Yoshifumi Itoh. "ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)." Molecular Biology of the Cell 26, no. 4 (2015): 659–73. http://dx.doi.org/10.1091/mbc.e14-10-1463.

Full text
Abstract:
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and transmits signals from various collagens in epithelial cells. However, how DDR1–dependent signaling is regulated has not been understood. Here we report that collagen binding induces ADAM10-dependent ectodomain shedding of DDR1. DDR1 shedding is not a result of an activation of its signaling pathway, since DDR1 mutants defective in signaling were shed in an efficient manner. DDR1 and ADAM10 were found to be in a complex on the cell surface, but shedding did not occur unless collagen bound to DDR1. Using a shedding-
APA, Harvard, Vancouver, ISO, and other styles
4

Petersen, F. C., S. Assev, H. C. van der Mei, H. J. Busscher, and A. A. Scheie. "Functional Variation of the Antigen I/II Surface Protein in Streptococcus mutans and Streptococcus intermedius." Infection and Immunity 70, no. 1 (2002): 249–56. http://dx.doi.org/10.1128/iai.70.1.249-256.2002.

Full text
Abstract:
ABSTRACT Although Streptococcus intermedius and Streptococcus mutans are regarded as members of the commensal microflora of the body, S. intermedius is often associated with deep-seated purulent infections, whereas S. mutans is frequently associated with dental caries. In this study, we investigated the roles of the S. mutans and S. intermedius antigen I/II proteins in adhesion and modulation of cell surface characteristics. By using isogenic mutants, we show that the antigen I/II in S. mutans, but not in S. intermedius, was involved in adhesion to a salivary film under flowing conditions, as
APA, Harvard, Vancouver, ISO, and other styles
5

Guimarães-Souza, Nadia Karina, Liliya Marsovna Yamaleyeva, Baisong Lu, Ana Claudia Mallet de Souza Ramos, Colin Edward Bishop, and Karl Erik Andersson. "Superoxide overproduction and kidney fibrosis: a new animal model." Einstein (São Paulo) 13, no. 1 (2015): 79–88. http://dx.doi.org/10.1590/s1679-45082015ao3179.

Full text
Abstract:
Objective To establish whether the mutation in the Immp2L gene induces renal fibrosis and whether aging exacerbates renal morphology in mice. Methods Female mutant mice with mutation in the inner mitochondrial membrane peptidase 2-like protein at 3 and 18 months of age were used. Renal fibrosis was analyzed using classic fibrosis score, Masson’s trichrome staining, and analysis of profibrotic markers using real time polymerase chain reaction (superoxide dismutase 1, metalloproteinase-9, erythropoietin, transforming growth factor beta), and immunostaining (fibroblasts and Type IV collagen). Oxi
APA, Harvard, Vancouver, ISO, and other styles
6

van der Plas, R., Lucio Gomes, J. Marquart, et al. "Binding of von Willebrand Factor to Collagen Type III: Role of Specific Amino Acids in the Collagen Binding Domain of vWF and Effects of Neighboring Domains." Thrombosis and Haemostasis 84, no. 12 (2000): 1005–11. http://dx.doi.org/10.1055/s-0037-1614163.

Full text
Abstract:
SummaryBinding of von Willebrand Factor (vWF) to sites of vascular injury is the first step of hemostasis. Collagen types I and III are important binding sites for vWF. We have previously determined the threedimensional structure of the collagen binding A3 domain of vWF (Huizinga et al., Structure 1997; 5: 1147). We hypothesized that the top face of this domain might be the collagen-binding site. Based on this hypothesis, we made seven vWF mutants (D934A/S936A, V1040A/ V1042A, D1046A, D1066A, D1069A, D1069R, and R1074A). Collagen binding of these mutants was investigated in ELISA and with Surf
APA, Harvard, Vancouver, ISO, and other styles
7

Marx, Isabelle, Olivier D. Christophe, Peter J. Lenting, et al. "Altered thrombus formation in von Willebrand factor–deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa." Blood 112, no. 3 (2008): 603–9. http://dx.doi.org/10.1182/blood-2008-02-142943.

Full text
Abstract:
Abstract The role of von Willebrand factor (VWF) in thrombosis involves its binding to a number of ligands. To investigate the relative importance of these particular interactions in the thrombosis process, we have introduced mutations into murine VWF (mVWF) cDNA inhibiting VWF binding to glycoprotein (Gp) Ib, GPIIbIIIa, or to fibrillar collagen. These VWF mutants were expressed in VWF-deficient mice (VWF−/−) by using an hydrodynamic injection approach, and the mice were studied in the ferric chloride–induced injury model. Expression of the collagen and the GPIIbIIIa VWF-binding mutants in VWF
APA, Harvard, Vancouver, ISO, and other styles
8

Cruz, Miguel A., and Liza D. Morales. "Mutations in the von Willebrand Factor A1 Domain That Increase the Affinity for Collagen Have Different Effects on the Binding to Glycoprotein Ib." Blood 104, no. 11 (2004): 3661. http://dx.doi.org/10.1182/blood.v104.11.3661.3661.

Full text
Abstract:
Abstract The interaction of plasma von Willebrand factor (VWF) with collagen at the site of vascular injury plays a critical role in the initiation of thrombus formation under high shear stress. It does this by forming a bridge between the fibrils of collagen in the subendothelium and the platelet glycoprotein Ib-IX-V complex (GPIb). The A1 domain of VWF is the binding site for GPIb whereas the collagen-function of VWF is controlled by both A1 and A3 domains. The VWF-A3 domain is important to support binding to fibrils of collagen Types I and III while the A1 domain is involved in the binding
APA, Harvard, Vancouver, ISO, and other styles
9

Mintz, Keith P. "Identification of an extracellular matrix protein adhesin, EmaA, which mediates the adhesion of Actinobacillus actinomycetemcomitans to collagen." Microbiology 150, no. 8 (2004): 2677–88. http://dx.doi.org/10.1099/mic.0.27110-0.

Full text
Abstract:
Actinobacillus actinomycetemcomitans is an aetiologic agent in the development of periodontal and some systemic diseases in humans. This pathogen localizes to the underlying connective tissue of the oral cavity in individuals with periodontal disease. The adhesion of A. actinomycetemcomitans to extracellular matrix components of the connective tissue prompted this study to identify gene products mediating the interaction of A. actinomycetemcomitans to these molecules. A transposon mutagenesis system was optimized for use in A. actinomycetemcomitans and used to generate an insertional mutant li
APA, Harvard, Vancouver, ISO, and other styles
10

Lankhof, Hanneke, Conchi Damas, Marion Schiphorst, et al. "Recombinant vWF Type 2A Mutants R834Q and R834W Show a Defect in Mediating Platelet Adhesion to Collagen, Independent of Enhanced Sensitivity to a Plasma Protease." Thrombosis and Haemostasis 81, no. 06 (1999): 976–83. http://dx.doi.org/10.1055/s-0037-1614609.

Full text
Abstract:
SummaryType 2A von Willebrand Disease (vWD) is characterized by the absence of high molecular weight von Willebrand factor (vWF) multimers in plasma which is caused by enhanced extracellular proteolysis or defective intracellular transport. We identified in vWD type 2A patients two mutations in the A2 domain at position 834 in which arginine (R) was substituted for glutamine (R834Q) or tryptophan (R834W). We reproduced these mutations in vWF cDNA and expressed the recombinant proteins in furin cDNA containing baby hamster kidney (fur-BHK) cells. The subunit composition and the multimeric struc
APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic "Collagen mutants"

1

陳卓榮 and Cheuk-wing Wilson Chan. "Molecular basis for increased bone formation in a mouse expressing mutant collagen X." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31227132.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Pfeiffer, Brent J. "Role of Proa(2)I collagen chains and collagen crosslinking in thoracic aortic biochemical integrity during aging using the OIM mouse model." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4397.

Full text
Abstract:
Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>Title from title screen of research.pdf file (viewed on December 22, 2006). The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2006" Includes bibliographical references.
APA, Harvard, Vancouver, ISO, and other styles
3

Brodeur, Amanda C. "Glomerular deposition of homotrimeric type I collagen in the COL1A2 deficient mouse." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4479.

Full text
Abstract:
Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>Title from title screen of research.pdf file (viewed on December 22, 2006). The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "May 2006" Vita. Includes bibliographical references.
APA, Harvard, Vancouver, ISO, and other styles
4

Ioannides, Marios. "Detection, Cloning, and Analysis of a U32 Collagenase in Streptococcus mutans GS-5." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000612.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Andrade, Caroline Gomes de. "Avaliação do potencial cariogênico de biofilmes contendo Candida albicans em relação à dentina radicular : estudo in vitro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/179883.

Full text
Abstract:
Após a exposição da raiz do dente na cavidade bucal, causada por recessão gengival, há uma mudança na microflora existente na região. Micro-organismos se depositam nessa região e formam um biofilme, que se exposto a carboidratos fermentáveis pode levar a uma queda de pH do meio, selecionando micro-organismos ácido-tolerantes e causando uma dissolução dos tecidos minerais e ativação de mecanismos de degradação da matriz orgânica da dentina. A presença de Candida albicans em lesões radiculares vem sendo relatada na literatura de forma controversa, alguns estudos sugerem que a cariogenicidade do
APA, Harvard, Vancouver, ISO, and other styles
6

Siriani, Luciana Kfouri. "Influência do gene cnm de Streptococcus mutans na formação de biofilme e na interação do microrganismo às células endoteliais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-19042013-110450/.

Full text
Abstract:
Streptococcus mutans é considerado um agente etiológico primário da cárie dentária e um importante agente etiológico da endocardite infecciosa. O microrganismo pode ser classificado em quatro sorotipos (c, e, f e k), sendo o sorotipo c o mais comumente prevalente na população. S. mutans também pode acessar a corrente sanguínea e colonizar células endoteliais das artérias coronárias, através de sua ligação e posterior invasão. O gene cnm, codificador de uma proteína de ligação ao colágeno encontrado em algumas cepas de S. mutans pode ser relacionado com sua virulência. Objetivos: (1) formação d
APA, Harvard, Vancouver, ISO, and other styles
7

Carson, Valerie. "Cloning and analysis of putative collegenases of the U32 family in Stretococcus mutans and Stretococcus agalactiae (Group B Stretococcus)." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001721.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Sandhu, Anjali. "Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4807.

Full text
Abstract:
Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal development, metabolism, longevity, neurobiology, and so on. Here, we have used C. elegans to understand the genetic regulation of skin barrier function and longevity. C. elegans dwells in an organically rich environment in the soil where it is exposed to various bacterial toxins and toxic chemicals. Under such conditions, it becomes very crucial for the worms to maint
APA, Harvard, Vancouver, ISO, and other styles
9

Harrington, Dean J., and R. R. B. Russell. "Identification and characterisation of two extracellular proteases of Streptococcus mutans." 1994. http://hdl.handle.net/10454/11595.

Full text
Abstract:
No<br>Streptococcus mutans was shown to produce two extracellular proteases capable of degrading both gelatin and collagen-like substrates. These enzymes have molecular masses of 52 and 50 kDa when analysed by SDS-PAGE. Both enzymes were inhibited by EDTA, but not by a range of other inhibitors with different specificities, indicating that they are metalloproteases. The activity of EDTA-inactivated enzymes could be restored by the addition of manganese and zinc. The identical inhibition and restoration profiles of the two enzymes suggest that one of the proteases may be a degradation product o
APA, Harvard, Vancouver, ISO, and other styles
10

Rebella, Gregory S. "Skeletal muscle collagen alterations induced by recombinant human growth hormone (rhGH) in the mutant dwarf rat." 1996. http://catalog.hathitrust.org/api/volumes/oclc/36400373.html.

Full text
Abstract:
Thesis (M.S.)--University of Wisconsin--Madison, 1996.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 56-61).
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Collagen mutants"

1

Abe, Yasuhiro, Tetsuya Nomura, Yasuo Yoshioka, Haruhiko Kamada, Shin-ichi Tsunoda, and Yasuo Tsutsumi. "Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis." In Advances in Experimental Medicine and Biology. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6612-4_51.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Collagen mutants"

1

Webb, Watt W. "Multiphoton Microscopy MPM: Imaging Spectra and Dynamics of Molecular Function Deep in Living Tissues." In In Vivo optical Imaging at the NIH. Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.msi3.

Full text
Abstract:
Multiphoton Excitation (MPE) of fluorescence provides the optimum photophysics for microscopic imaging deep in living tissue with minimal photodamage, to depths so far ~ 400 µm. Tissue autofluorescence excited by two-photon or three-photon absorption to ultra-violet energies can provide specific indications of disease. Useful autofluorescence of serotonin (5HT), melatonin, indolamine breakdown products, NADH, collagen, elastin, and a number of yet-to-be-identified molecular species, some of which identify disease states are already being imaged routinely. For research in model animals, genetic
APA, Harvard, Vancouver, ISO, and other styles
2

Delgado-Goni, Teresa, Slawomir Wantuch, Teresa Casals-Galobart, et al. "Abstract 4108: Longitudinal diffusion-weighted MRI assessment of NRAS mutant melanoma response to dual RAF-MEK inhibition reveals differences associated with collagen deposition." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4108.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Collagen mutants"

1

Fluhr, Robert, and Maor Bar-Peled. Novel Lectin Controls Wound-responses in Arabidopsis. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697123.bard.

Full text
Abstract:
Innate immune responses in animals and plants involve receptors that recognize microbe-associated molecules. In plants, one set of this defense system is characterized by large families of TIR–nucleotide binding site–leucine-rich repeat (TIR-NBS-LRR) resistance genes. The direct interaction between plant proteins harboring the TIR domain with proteins that transmit and facilitate a signaling pathway has yet to be shown. The Arabidopsis genome encodes TIR-domain containing genes that lack NBS and LRR whose functions are unknown. Here we investigated the functional role of such protein, TLW1 (TI
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography