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Relevant bibliographies by topics / Collagen Type 1 CTGF

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Academic literature on the topic 'Collagen Type 1 CTGF'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Collagen Type 1 CTGF"

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Takeuchi, H., S. Kubota, E. Murakashi, et al. "Nicotine-induced CCN2: from Smoking to Periodontal Fibrosis." Journal of Dental Research 89, no. 1 (2009): 34–39. http://dx.doi.org/10.1177/0022034509353403.

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Since fibrosis is observed in smokers’ gingiva, it was hypothesized that fibrosis was caused by nicotine in the periodontium. Therefore, in this study, we investigated the effects of nicotine on the induction of a profibrotic molecule, connective tissue growth factor (CCN2/CTGF), in human gingival fibroblasts (HGFs) and periodontal ligament (PDL) cells. With 1 μg/mL nicotine, vacuolization and attenuated proliferation were observed. Interestingly, 1 μg/mL nicotine increased the production of CCN2/CTGF protein in both cells without increasing mRNA expression. Furthermore, type I collagen mRNA a

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Romero, Jose R., Dennis A. Ricupero, Alicia Rivera, Ronald H. Goldstein, and Paul R. Conlin. "Activation of Na + /Ca 2+ Exchanger in Kinin B 1 Receptor-Stimulated Human Fibroblast Is Associated with Collagen Production." Hypertension 36, suppl_1 (2000): 710–20. http://dx.doi.org/10.1161/hyp.36.suppl_1.710.

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P148 The arterial wall in hypertension is characterized by thickening of the media, in part due to increased deposition of connective tissue. Autocrine and paracrine factors may participate in this process; including products of the kallikrein-kinin system. We evaluated early signal transduction events and effects on collagen formation in B 1 -stimulated human myofibroblast cells (IMR-90). We measured cytosolic calcium (Ca cyt ) levels in cells loaded with FURA-2AM. Gene expression of connective tissue growth factor (CTGF) and α1(I) collagen was determined by estimating mRNA levels using North

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Chen, Chung-Ming, Hsiu-Chu Chou, Leng-Fang Wang, and Yaw-Dong Lang. "Experimental Oligohydramnios Decreases Collagen in Hypoplastic Fetal Rat Lungs." Experimental Biology and Medicine 233, no. 11 (2008): 1334–40. http://dx.doi.org/10.3181/0803-rm-99.

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Neonates with premature rupture of the membrane and oligohydramnios have an increased risk of acute respiratory morbidity. The aims of this study are to investigate the effects of experimental oligohydramnios on transforming growth factor (TGF)-β1 and connective tissue growth factor (CTGF) expressions and collagen level in fetal rat lungs. On day 16 of gestation, we anesthetized timed pregnant Sprague-Dawley dams, punctured the uterine wall and fetal membranes of each amniotic sac which resulted in oligohydramnios. Fetuses in the opposite uterine horn served as controls. On days 19 and 21 of g

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Zhou, Hong, Caixia Fang, Lihui Zhang, Yonggui Deng, Mian Wang, and Fengling Meng. "Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes." Chinese Medical Journal 127, no. 2 (2014): 225–31. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20131917.

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Background Hyperglycemia may accelerate liver fibrosis. Currently, there is no effective treatment for liver fibrosis induced by type 2 diabetes. The study aim was to investigate whether RhoA/Rho kinase (ROCK) pathway is involved in liver fibrosis in the rats with type 2 diabetes and define the protective effects of fasudil on livers. Methods A rat model of type 2 diabetes was established by high fat diet combined with streptozotocin (30 mg/kg, intraperitoneal injection). Animals were randomly assigned to 3 groups: control rats, untreated diabetic rats that received vehicle and fasudil-treated

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Wang, Shinong, та Raimund Hirschberg. "BMP7 antagonizes TGF-β-dependent fibrogenesis in mesangial cells". American Journal of Physiology-Renal Physiology 284, № 5 (2003): F1006—F1013. http://dx.doi.org/10.1152/ajprenal.00382.2002.

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Exogenous administration of recombinant human bone morphogenetic protein (BMP)-7 was recently shown to ameliorate renal glomerular and interstitial fibrosis in rodents with experimental renal diseases. We tested the hypothesis that BMP7 functions by antagonizing profibrogenic events that are induced by transforming growth factor (TGF)-β in cultured mesangial cells. Incubation of murine mesangial cells with TGF-β (50–200 pM) increased cell-associated collagen type IV and fibronectin, soluble collagen type IV, thrombospondin, and connective tissue growth factor (CTGF). Coincubation with recombin

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Chaqour, Brahim, Catherine Whitbeck, Ji-Soo Han, et al. "Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction." American Journal of Physiology-Endocrinology and Metabolism 283, no. 4 (2002): E765—E774. http://dx.doi.org/10.1152/ajpendo.00131.2002.

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Cysteine-rich protein (Cyr61) and connective tissue growth factor (CTGF) are key immediate early growth factors with functions in cell proliferation, differentiation, and extracellular matrix synthesis. Studies were performed to assess the gene expression profile of Cyr61 and CTGF in rat urinary bladder during growth in response to partial outlet obstruction. The mRNA levels of Cyr61 as determined by ribonuclease protection assay increased sharply after 1 day and remained elevated throughout the time period of the obstruction. This correlates well with increased bladder weight. The CTGF mRNA l

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Zhang, Lin, Jin Tan, Yi-Ping Liu, Xun Liu та Mang Luo. "Curcumin relieves the arecoline-induced fibrosis of oral mucosal fibroblasts via inhibiting HIF-1α/TGF-β/CTGF signaling pathway: an in vitro study". Toxicology Research 10, № 3 (2021): 631–38. http://dx.doi.org/10.1093/toxres/tfab046.

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Abstract Oral submacosal fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis. The current treatments for OSF have failed to achieve the desired curative effect. Here, we propose that curcumin has excellent therapeutic effect on OSF and explore its specific mechanism. Transwell assay was performed to detected cell migration. Flow cytometry was used to measured apoptosis. And MTT assay was performed to test cell viability. Gene and protein levels were detected by quantitative real-time polymerase cha

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Hillege, Michèle, Ricardo Galli Caro, Carla Offringa, Gerard de Wit, Richard Jaspers та Willem Hoogaars. "TGF-β Regulates Collagen Type I Expression in Myoblasts and Myotubes via Transient Ctgf and Fgf-2 Expression". Cells 9, № 2 (2020): 375. http://dx.doi.org/10.3390/cells9020375.

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Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of muscle mass, and contributes to the progressive pathology of muscle wasting disorders. However, little is known regarding the time-dependent signalling of TGF-β in myoblasts and myotubes, as well as how TGF-β affects collagen type I expression and the phenotypes of these cells. Here, we assessed effects of TGF-β on gene expression in C2C12 myoblasts and myotubes after 1, 3, 9, 24 and 48 h treatment. In myoblasts, various myogenic genes were repressed after 9, 24 and 48 h, while in myotubes only a reductio

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McDonald, Emily A., Ling Cheng, Blanca Jarilla, et al. "Maternal Infection with Schistosoma japonicum Induces a Profibrotic Response in Neonates." Infection and Immunity 82, no. 1 (2013): 350–55. http://dx.doi.org/10.1128/iai.01060-13.

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ABSTRACTThe global burden of schistosomiasis is significant, with fibrosis a major associated morbidity and the primary cause of mortality. We have previously shown that schistosomiasis during pregnancy upregulates proinflammatory cytokines in the cord blood. In this study, we extend these findings to include a large panel of fibrosis-associated markers. We developed a multiplex bead-based assay to measure the levels of 35 proteins associated with fibrosis. Cord blood from 109 neonates born to mothers residing in an area ofSchistosoma japonicumendemicity was assessed for these molecules. Ten m

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Roestenberg, Peggy, Frans A. van Nieuwenhoven, Jaap A. Joles, et al. "Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice." American Journal of Physiology-Renal Physiology 290, no. 6 (2006): F1344—F1354. http://dx.doi.org/10.1152/ajprenal.00174.2005.

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Connective tissue growth factor (CTGF) is overexpressed in diabetic nephropathy (DN) and has therefore been implicated in its pathogenesis. The objective of the present study was to determine the tissue distribution of increased CTGF expression and the relationship of plasma, urinary, and renal CTGF levels to the development and severity of DN. We studied the relationship between CTGF and renal pathology in streptozotocin (STZ)-induced diabetes in C57BL/6J mice. Diabetic and age-matched control mice were killed after 1, 2, 4, and 9 wk of diabetes. In addition, key parameters of diabetes and DN

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Dissertations / Theses on the topic "Collagen Type 1 CTGF"

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Zhou, Zhenqing. "BIOLOGICAL SIGNIFICANCE OF HEPARIN-BINDING GROWTH FACTORS HB-EGF AND CTGF." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1258498601.

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Mackay, Katrina. "Molecular analysis of type 1 collagen genes in inherited disorders." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34442.

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The collagens are a family of related proteins which contain at least one triple-helical domain, a structure which is determined by the unique amino acid sequence of the polypeptide subunits. These proteins each have a specific function in the extracellullar matrices of connective tissues of multicellular organisms. In humans, type I collagen, the most abundant collagen type, is the major structural component of skin, tendon and bone. Mutations in the two genes encoding the subunits of type I collagen, COL1A1 and COL1A2, result in heterogeneous phenotypes. Some mutations result in osteogenesis

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Tang, Ming. "Atomic-scale biophysics modelling of type I collagen in the extracellular matrix." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/124650/1/Ming_Tang_Thesis.pdf.

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This thesis explores the biophysics of collagen in the extracellular matrix under external stimuli, by performing cutting edge MD simulations. The obtained results provide significant insights into the design and manufacturing of artificial biomaterials for surgical tissue treatments, of collagen for regenerative medicine applications, and of gold nanoparticles for biomedical applications. The probed biophysical properties consist of the structural properties and the mechanical properties, where the mechanical properties of collagen are regulated by its structure at different levels of hierarc

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Dzobo, Kevin. "Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3125.

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Includes abstract.<br>Includes bibliographical references (leaves 122-157).<br>Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the most abundant extracellular matrix protein in the human body and is found in tissues requiring high tensile strength. In this study we investigated the effect of a pre-formed fibroblast-derived extracellular matrix on the ex

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Soininen, Raija. "Structure of the gene for the [alpha] 1 chain of human type IV collagen." Oulu, Finland : University of Oulu, 1989. http://catalog.hathitrust.org/api/volumes/oclc/20482376.html.

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Seehra, Kamaljit Jyoti Kaur. "An investigation into mechanisms inhibiting human microvascular endothelial cell (HMEC-1) capillary cord formation on collagen type 1." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438638.

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Стужук, Анастасія Юріївна. "Способи отримання та перспективи застосування колагену типу 1". Магістерська робота, Київський національний університет технологій та дизайну, 2021. https://er.knutd.edu.ua/handle/123456789/19255.

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Дипломна магістерська робота присвячена вивченню способів отримання та перспектив застосування колагену типу 1 у різних галузях промисловості. У роботі наведено критичний огляд літературних джерел, присвячених застосуванню та отриманню колагену, обґрунтовано технологічну схему отримання сухого препарату колагену з відходів шкіряного виробництва за допомогою Bacillus subtilis, яка передбачає, в тому числі, стадії отримання посівного матеріалу, вирощування культури та культивування, поділ отриманого гідролізату на фракції та фільтрацію. Обґрунтовано вибір технологічного обладнання для реалізації

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Miles, Benjamin Nicholas. "On the use of collagen type-I in the growth of hydroxyapatite on micro-fabricated biomimetic dentin." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58203.

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Dentin hypersensitivity is a condition that affects 4 – 14% of western populations like the U.K. It is characterised by a short sharp pain in the gums, usually experienced when an individual consumes cold food or drink. Typical treatments that are primarily delivered by sensitive toothpastes initially relied upon disruption of neuronal activity with potassium ions. However, more recently the most advanced over the counter treatments now act to occlude the tubules present in dentin that are involved in the hydrodynamic cause of dentinal pain. Pre-clinically, the efficacy of these occlusive trea

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Afifi, Amal. "A molecular investigation into type 1 collagen genes in Osteogenesis imperfecta and an evaluation of targeted gene repair." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422178.

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Ndlovu, Matladi N. "The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/3144.

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Bibliography leaves 70-97.<br>Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression.

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Books on the topic "Collagen Type 1 CTGF"

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Kontusaari, Sirpa. Type III collagen: Primary structure of the pro[alpha]1(III) chain and mutations in the gene (COL3A1) in Ehlers-Danlos syndrome type IV and familial aortic aneurysm. University of Oulu], Biocenter and Department of Biochemistry, 1991.

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Lee, Hyejin (Rosa). Critical role of membrane-type 1 matrix metalloproteinase in collagen phagocytosis by fibroblasts. 2007.

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Heidet, Laurence, Bertrand Knebelmann, and Marie Claire Gubler. Alport syndrome. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0321.

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Alport syndrome is an inherited renal disorder characterized by early haematuria, progressing to proteinuria, sensorineural hearing loss, and progressive renal failure typically in the third or fourth decade but with wide variation. It is responsible for about 1% of end-stage renal failure. Over 80% of cases are X-linked and young men are most affected, but heterozygous carriers of the abnormal gene are also at significantly increased risk of end-stage renal failure in their lifetime. Those affected by the autosomal recessive variant are phenotypically very similar. It is caused by mutations i

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DeAugustinas, M., and A. Kiely. Infectious Keratitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0016.

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Keratitis is an inflammation of the cornea, which can lead to corneal opacification or ulceration. The most common cause of infectious keratitis is herpes simplex virus type 1 (HSV-1). Noninfectious corneal infiltrates related to trauma, collagen vascular disease, autoimmune inflammation, vasculitis, or atopy (which predisposes to HSV keratitis) must be considered. HSV-associated stromal keratitis is the most common cause of infectious corneal blindness in the United States, yet its presentation can be fairly subtle. For this reason, symptoms out of proportion to exam findings or a history con

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Cui, Zhao, Neil Turner, and Ming-hui Zhao. Alport post-transplant antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0075.

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Alport antiglomerular basement membrane (anti-GBM) disease is a rare example of disease caused by allo-sensitization after renal transplantation, first described in 1992. Because the recipient lacks a specific glomerular basement membrane (GBM) protein, they can become sensitized to the normal molecule present in the GBM of the donor kidney. The disease is restricted to the allograft. Interestingly severe disease arises from this only arises rarely, certainly less than 1 in 20, probably closer to 1 in 50. It characteristically causes late graft loss in a first transplant with accelerated tempo

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Bardin, Thomas, and Tilman Drüeke. Renal osteodystrophy. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149.

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Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by h

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Book chapters on the topic "Collagen Type 1 CTGF"

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Yamauchi, Mitsuo, Marnisa Sricholpech, Masahiko Terajima, Kenneth B. Tomer, and Irina Perdivara. "Glycosylation of Type I Collagen." In Post-Translational Modification of Proteins. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9055-9_9.

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Ralston, Stuart H. "Type I Collagen Polymorphisms and Osteoporosis." In The Genetics of Osteoporosis and Metabolic Bone Disease. Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-033-9_4.

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Rittié, Laure. "Type I Collagen Purification from Rat Tail Tendons." In Fibrosis. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7113-8_19.

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Rishikof, David C., Ping-Ping Kuang, Mangalalaxmy Subramanian, and Ronald H. Goldstein. "Methods for Measuring Type I Collagen Synthesis In Vitro." In Fibrosis Research. Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-940-0:129.

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Massimini, Marcella, Mariarita Romanucci, Raffaella De Maria, and Leonardo Della Salda. "Histological Evaluation of Long-Term Collagen Type I Culture." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2403-6_10.

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De Wever, Olivier, An Hendrix, Astrid De Boeck, et al. "Single Cell and Spheroid Collagen Type I Invasion Assay." In Methods in Molecular Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8244-4_2.

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Annenkov, Alexander E., and Yuti Chernajovsky. "Gene Transfer to Lymphocytes Targeting Cartilaginous Collagen Type II." In Modern Therapeutics in Rheumatic Diseases. Humana Press, 2002. https://doi.org/10.1007/978-1-59259-239-5_33.

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Liu, Anjun, Hui Zhang, Ying Chen, Hongshuo Chen, Huihui Liu, and Xiaodan Guo. "Anti-Arthritic Effects of Chondroitin Sulfate and Type II Collagen in Collagen-Induced Arthritis Mice." In Lecture Notes in Electrical Engineering. Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-4802-9_102.

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Yao, Shasha, Yifei Xu, Changyu Shao, Fabio Nudelman, Nico A. J. M. Sommerdijk, and Ruikang Tang. "A Biomimetic Model for Mineralization of Type-I Collagen Fibrils." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9095-5_4.

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Massimini, Marcella, Mariarita Romanucci, Raffaella De Maria, and Leonardo Della Salda. "Correction to: Histological Evaluation of Long-Term Collagen Type I Culture." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2403-6_17.

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Conference papers on the topic "Collagen Type 1 CTGF"

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Juncosa-Melvin, Natalia, Karl S. Matlin, Robert W. Holdcraft, Victor S. Nirmalanandhan, and David L. Butler. "Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell: Collagen Sponge Constructs for Patellar Tendon Repair." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175807.

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Tendons (rotator cuff, Achilles and patellar tendons) are among the most commonly injured soft tissues [1]. Many repairs/reconstructions have been attempted using sutures, resorbable biomaterials, autografts, and allografts, but with varying success. A tissue engineered repair using mesenchymal stem cells (MSCs) is attractive [2–4] but often lacks initial stiffness and strength [5].

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Gaudet, Ian D., and David I. Shreiber. "Photocrosslinkable Type-I Collagen for In Situ Material Modification." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53125.

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Hydrogels are attractive materials for use as tissue engineering scaffolds [1]. Natural hydrogels, such as collagen, are both cytocompatible and highly biofunctional. However, they have somewhat constrained material properties and have an inherently large variability in composition due to their biological origin, making them more difficult to work with from an engineering viewpoint[2–4]. Here, we aim to use type 1 collagen — the most abundant protein in the body that maintains excellent cytocompatibility and can self assemble into a fibrillar network — as a base component for a photocrosslinka

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Gyoneva, Lazarina, Mohammad F. Hadi, Yoav Segal, Kevin D. Dorfman, and Victor H. Barocas. "Role of Lateral Interactions in Type IV Collagen Network Mechanics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14625.

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The basement membrane is a specialized part of the extra-cellular matrix. It is usually characterized as a scaffold for epithelial cells but in some tissues it serves other, mechanical, roles [1]. The mechanical properties of the basement membrane are mainly determined by one of its main constituents — type IV collagen. Unlike the well-known fibrous type I collagen, collagen IV assembles into planar networks (Fig. 1) [2]. The α 1(IV) and α 2(IV) collagen IV chains assemble into the so-called major chain network, present in all basement membranes. The α 3(IV), α 4(IV), α 5(IV) collagen IV chain

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Gee, Albert O., Brendon M. Baker, and Robert L. Mauck. "Mechanics and Cytocompatibility of Genipin Crosslinked Type I Collagen Nanofibrous Scaffolds." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193220.

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Collagen is a principal constituent of the extracellular matrix (ECM) and as such, defines the microenvironmental milieu in which cells reside. In fiber-reinforced musculoskeletal tissues, collagen fibers are highly organized and generate the direction-dependent mechanical properties critical to the function of these structures. Given its primary role, collagen is particularly attractive for tissue engineering (TE) applications where scaffolds are coupled with cells to repair or regenerate damaged tissues. One method for producing collagen-based scaffolds is through electrospinning. This techn

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Schuliga, Michael, Trudi Harris, and Alastair Stewart. "Plasmin Formation By Airway Smooth Muscle Is Accelerated By Culture On Fibrillar Type 1 Collagen." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2078.

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Lai, Victor K., Allan M. Kerandi, Spencer P. Lake, Robert T. Tranquillo, and Victor H. Barocas. "Collagen Network Architecture Varies Between Pure Collagen and Collagen-Fibrin Co-Gels." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80738.

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Naturally-occurring extracellular matrix (ECM) proteins, e.g. collagen I and fibrin, play an important role in tissues, conferring structural integrity and providing a biochemical environment for eliciting important cellular responses (e.g. migration). Tissue engineers use a variety of matrix polymers as initial scaffolds for seeding cells, sometimes in combination with one another (e.g. collagen-fibrin [1]). For example, our group fabricates arterial tissue equivalents (TEs) by seeding cells in a fibrin gel, which is gradually degraded over time and replaced by cell-produced collagen [2]. Whi

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Lambert, C., D. Borderie, F. Rannou, and Y. Henrotin. "SAT0052 The coll2–1 peptide of collagen type ii: a new actor of synovitis in osteoarthritis." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.1036.

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Rada, Miran, Catherine Eldred, Jessica Sage, Sandra Orsulic, and Dong-Joo Cheon. "Abstract TMEM-017: COLLAGEN TYPE XI ALPHA 1 (COL11A1) IS A NOVEL STROMAL MEDIATOR OF CHEMORESISTANCE." In Abstracts: 11th Biennial Ovarian Cancer Research Symposium; September 12-13, 2016; Seattle, WA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.ovcasymp16-tmem-017.

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Jensen, Christina, Anders Kverneland, Marco Donia, et al. "Abstract 388: Non-invasive biomarker potential of the fibroblast-derived collagen type III and collagen type XI for predicting outcome in metastatic melanoma patients treated with anti-PD-1 therapy." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-388.

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Dong, X. Neil, Mahyar Zoghi, Qitao Ran, and Xiaodu Wang. "Less Diffuse Damage was Observed in Osteogenesis Imperfecta Mice Femurs Than Wild-Type Controls." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19401.

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Abstract:

Accumulation of microdamage contributes to the deterioration of bone quality with aging among the elderly [1]. Microdamage formation in bone is dependent on its ultrastructural constituents. At the ultrastructural level, bone is a fiber-reinforced composite material in which mineral crystals are responsible for its stiffness and collagen fibrils offer its toughness [2]. Using animal models with distinct mineralization levels (BL6 and C3H mice), a previous study has demonstrated that highly mineralized bone tend to form linear microcracks whereas less mineralized bone is more likely to have dif

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Reports on the topic "Collagen Type 1 CTGF"

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Sumrejkanchanakij, Piyamas, Prasit Pavasant, and Tusanee Yongchaitrakul. The influence of collagen I on Insulin-like growth factor-I induced Osteopontin expression in human periodontal ligament fibroblasts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.14.

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Extracellular matrix and growth factors are the crucial factors that regulate healing and regenerating process in human periodontal ligament (HPDL) cells. The purpose of this study was to examine the effects of type I collagen and insulin-like growth factor-I (IGF-I) on osteopontin (OPN) expression. The data showed that OPN expression was significantly decreased when cells were cultured on collagen-coated plates. Addition of IGF-I obviously induced OPN expression only in a collagen-coated condition, suggesting an attenuation effect of IGF-I on OPN expression inhibited by type I collagen. Cells

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Lertchirakarn, Veera, and Prasit Pavasant. The effects of fluocinolone acetonide on human cultured dental pulp cell in vitro. Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.15.

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The purpose of treatment of pulpal exposure is to preserve vitality, healthy and promote healing of exposed pulp tissue. Fluocinolone acetonide (FA) may have a potential to promote tissue healing. The aim of this study was therefore to investigate the effects of FA on human cultured dental pulp cell in vitro. The MTT assay was performed to examine both cytotoxicity and prolifration of FA at 24, 48 and 72 hours. The results revealed that FA (0.1 to 50 [mu]M) had no cytotoxicity effect. In addition, these doses also stimulated cell proliferation. There was a significant increase of cell prolifer

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