To see the other types of publications on this topic, follow the link: Collecte IP.
Journal articles on the topic 'Collecte IP'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Collecte IP.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Kim, Sang-Soo, Koo-Rack Park, and Dong-Hyun Kim. "A Study on Methodology of Media Contents Automatically Collect and Transform based IP." Journal of Digital Convergence 13, no. 9 (September 28, 2015): 287–95. http://dx.doi.org/10.14400/jdc.2015.13.9.287.
Full text
2
Hargarten, S. W. "Suicide guns: why collect this information?" Injury Prevention 6, no. 4 (December 1, 2000): 245–46. http://dx.doi.org/10.1136/ip.6.4.245.
Full text
3
Grombacher, Denys, Esben Auken, Nikolaj Foged, Thue Bording, Neil Foley, Peter T. Doran, Jill Mikucki, et al. "Induced polarization effects in airborne transient electromagnetic data collected in the McMurdo Dry Valleys, Antarctica." Geophysical Journal International 226, no. 3 (May 5, 2021): 1574–83. http://dx.doi.org/10.1093/gji/ggab148.
Full textAbstract:
SUMMARY Airborne electromagnetics (EM) is a geophysical tool well suited to mapping glacial and hydrogeological structures in polar environments. This non-invasive method offers significant spatial coverage without requiring access to the ground surface, enabling the mapping of geological units to hundreds of metres depth over highly varied terrain. This method shows great potential for large-scale surveys in polar environments, as common targets such as permafrost, ice and brine-rich groundwater systems in these settings can be easily differentiated because of their significant contrasts in electrical properties. This potential was highlighted in a 2011 airborne EM survey in the McMurdo Dry Valleys that mapped the existence of a large-scale regional groundwater system in Taylor Valley. A more comprehensive airborne EM survey was flown in November 2018 to broadly map potential groundwater systems throughout the region. Data collected in this survey displayed significant perturbations from a process called induced polarization (IP), an effect that can greatly limit or prevent traditional EM workflows from producing reliable geological interpretations. Here, we present several examples of observed IP signatures over a range of conditions and detail how workflows explicitly designed to handle IP effects can produce reliable geological interpretations and data fits in these situations. Future polar EM surveys can be expected to encounter strong IP effects given the likely presence of geological materials (e.g. ice and permafrost) that can accentuate the influence of IP.
4
Santoso, Bambang Gunawan. "Intellectual Property Animasi Di Indonesia Dalam Buku Katalog Nganimasi Indonesia." Jurnal Bahasa Rupa 1, no. 2 (April 21, 2018): 89–98. http://dx.doi.org/10.31598/bahasarupa.v1i2.221.
Full textAbstract:
IP or Intellectual Property refers to the creation of the mind; invention; literary and artistic works; symbols, names and drawings used in the trade. Intellectual property rights (HKI) are rights granted to IP creators, and include trademarks, copyrights, patents, industrial design rights, and in some trade secret jurisdictions. Works of art including music and literature, as well as discoveries, words, phrases, symbols and designs can all be protected as intellectual property or IP. Until now the catalog book "IP Animasi Indonesia" does not exist yet; while other countries such as Korea have released an annual catalog of animations since 2005. (The author data when he got 6 months internship scholarship at KOCCA - Korea Creative Content Agency in 2008, and a special invitation to Korea in November 2015). So through the process of collecting data with the method of collecting data periodically (time series) for more than 1.5 years, the author ventured to collect the work of colleagues from almost all of Indonesia. Once collected, the data is sorted, tidied up, rearranged, and then compiled in a book entitled NGANIMASI INDONESIA: Indonesia Animation Industry Data (NI). The results of this study revealed that until August 2017 there were 56 IPs categorized in animation character collected. 64% of the 56 IPs are character designs of humans or people; while the remaining 36% are animals, objects, and custom characters.
5
Dranger, T. S., and R. Priemer. "Collective process circuit that sorts." IEE Proceedings - Circuits, Devices and Systems 144, no. 3 (1997): 145. http://dx.doi.org/10.1049/ip-cds:19971148.
Full text
6
Ortín-Piqueras, Victoria, Tobias L. Freitag, Leif C. Andersson, Sanna H. Lehtonen, Seppo K. Meri, Thomas Spillmann, and Rafael Frias. "Urinary Excretion of Iohexol as a Permeability Marker in a Mouse Model of Intestinal Inflammation: Time Course, Performance and Welfare Considerations." Animals 11, no. 1 (January 4, 2021): 79. http://dx.doi.org/10.3390/ani11010079.
Full textAbstract:
Intestinal permeability (IP) tests are used to assess intestinal damage in patients and research models. The probe iohexol has shown advantages compared to 51Cr-EDTA or absorbable/nonabsorbable sugars. During IP tests, animals are housed in metabolic cages (MCs) to collect urine. We examined the performance of an iohexol IP test in mice. Rag1-/- (C57BL/6) mice of both sexes were divided into controls or treatment groups, the latter receiving injections of effector/memory T cells to induce intestinal inflammation. After two, four and five weeks (W), a single dose of iohexol was orally administered. Urine was collected seven times over 24 h in MCs. Iohexol concentration was measured by ELISA. Intestinal histological damage was scored in duodenal sections. In control and treated mice of both sexes, urinary excretion of iohexol peaked at 4 h. From W2 to W4/W5, urinary iohexol excretion increased in treated mice of both sexes, consistent with development of duodenitis in this model. Positive correlations were observed between the urinary excretion of iohexol in W4/W5 and the histological severity of duodenitis in treated male mice. We conclude that a 6 h cumulative urine sample appears sufficient to evaluate small IP to iohexol in this mouse model, improving animal welfare by reducing cage periods.
7
Macnae, James. "Quantitative estimation of intrinsic induced polarization and superparamagnetic parameters from airborne electromagnetic data." GEOPHYSICS 81, no. 6 (November 2016): E433—E446. http://dx.doi.org/10.1190/geo2016-0110.1.
Full textAbstract:
The primary aim of my research is to improve the characterization of induced polarization (IP) responses in airborne electromagnetic (AEM) survey data. The principal objectives are to test alternative methodologies for quantitative modeling and inversion to extract the spatial variation of IP parameters using the inductively thin-sheet model. The methods tested first fit, by nonnegative least squares, an AEM decay to the early delay time data, using thin-sheet basis functions. This modeled AEM decay is assumed to represent the IP source. It is then convolved with a few Cole-Cole models spanning the range of parameter sensitivity to get IP basis functions appropriate for the AEM excitation. Method 1 fits a linear sum of several AEM basis functions plus one IP basis function at a time and chooses the model with least-fitting error at late delay times. Method 2 fits a linear sum of several IP and several AEM basis functions. Both methods fit IP affected airborne data well, with normalized fitting errors being reduced by a significant factor when IP affects the data and is taken into account. Using penalty weights, superparamagnetic (SPM) effects can be simultaneously estimated in the fitting process. Without such weighting, SPM and IP parameter estimations are unstable. Cole-Cole models predict that the sensitivity of inductive airborne IP collected at 25 or 30 Hz base frequency indicates little overlap with galvanic ground IP collected with a 0.125 Hz waveform. Many easy IP sulfide targets with IP physical properties determined by ground surveys are predicted not to have a detectable airborne IP response. Clays, however, are predicted to have a small detectable background response that for airborne data would not be well-fitted by a single Cole-Cole response.
8
Torbic, Heather, Nicole Glasser, Sara E. Rostas, Mohammed Alquwaizani, and Gaspar Hacobian. "Intrapleural Antimicrobial Irrigation for Postpneumonectomy Empyema in Patients With Lung Cancer." Journal of Pharmacy Practice 28, no. 5 (August 8, 2014): 469–72. http://dx.doi.org/10.1177/0897190014544787.
Full textAbstract:
Purpose: Postpneumonectomy empyema (PPE) is a possible complication after a pneumonectomy in patients with lung cancer. The use of intrapleural (IP) antibiotic irrigation to treat infections in the pleural space may be indicated after systemic antimicrobial therapy, and drainage of the pleural space has been insufficient. Methods: Adult patients ≥18 years old who received IP antibiotic irrigation between 2006 and 2011 were included. Demographic data, past medical history, surgical procedure, systemic antibiotics, and culture data were collected. Additionally, the IP antibiotic administered, the dose, and how it was prepared and administered were collected. Results: A total of 18 patients were evaluated in this retrospective descriptive analysis. The majority of patients underwent an extrapleural pneumonectomy (EPP; 72%). Most patients received systemic antibiotics before IP antibiotic administration (95%). Vancomycin was the most common antibiotic used for both systemic therapy (100%) and IP irrigation (94%). The median number of IP antibiotic doses received per patient was 5.5 (interquartile range [IQR] 1-9). Recurrence of PPE within 6 months of initial PPE resolution occurred in 28% of patients. Intrapleural antibiotic irrigation was well tolerated in all patients. Conclusion: Vancomycin is most commonly used for IP antibiotic irrigation at our institution after patients have undergone a thoracic surgery, which was most commonly an EPP.
9
Gujo, Amelo Bolka, and Assefa Philipos Kare. "Prevalence of Intestinal Parasite Infection and its Association with Anemia among Children Aged 6 to 59 Months in Sidama National Regional State, Southern Ethiopia." Clinical Medicine Insights: Pediatrics 15 (January 2021): 117955652110292. http://dx.doi.org/10.1177/11795565211029259.
Full textAbstract:
Background: Previous studies conducted in Ethiopia revealed anemia as a severe public health problem among under-5 children but failed to associate with parasite infection. This study was aimed at assessing the prevalence of intestinal parasite infection (IP) and its association with anemia among children aged 6 to 59 months in Yirgalem General Hospital, Southern Ethiopia. Method: Institution based cross-sectional study was conducted in 2020 on 367 children aged 6 to 59 months. Trained data collectors administered the questionnaire. Blood was collected and analyzed for hemoglobin using the HemoCue 301. The stool samples were collected and analyzed. Association between IP and anemia was measured using multivariable analysis. The outputs are presented using an adjusted odds ratio (AOR) with 95% confidence intervals. Results: The prevalence of anemia was 48.8% (95% CI: 43.7, 53.9). Anemia was of mild, moderate, and severe type in 24.5%, 21.5%, and 2.8% of the children respectively. The prevalence of IP was 43.3% (95% CI: 38.2, 48.3). The odds of anemia were higher among children infected with IP (AOR = 3.19, 95% CI: 1.97, 5.17), large family size (AOR = 2.13, 95% CI: 1.26, 3.59), low-income level (AOR = 2.05, 95% CI: 1.25, 3.35), and MUAC < 11 cm (AOR = 3.27, 95% CI: 1.85, 5.81). Conclusions: The prevalence of IP was high. Anemia has severe public health significance. IP infection, income level, family size, and MUAC level were associated with anemia in children. Strengthening existing programs to prevent childhood anemia, and IP recommended.
10
Toros, Harmonie, and Luca Mavelli. "Collective evil and individual pathology: The depoliticization of violence against Afghan civilians." International Politics 51, no. 4 (May 16, 2014): 508–24. http://dx.doi.org/10.1057/ip.2014.23.
Full text
11
Tau, C. S., and T. I. Wang. "Performance evaluation of the loss-collected retransmission scheme in reliable multicast protocol." IEE Proceedings - Communications 153, no. 3 (2006): 376. http://dx.doi.org/10.1049/ip-com:20050150.
Full text
12
Luo, Bei, Yeling Ou, Biao Pan, Jian Qiu, and Takao Itoh. "The structure and development of interxylary and external phloem in Aquilaria sinensis." IAWA Journal 39, no. 1 (February 20, 2018): 3–17. http://dx.doi.org/10.1163/22941932-20170182.
Full textAbstract:
The structure and development of interxylary phloem (IP) and external phloem in Aquilaria sinensis were investigated using light and scanning electron microscopy. Complete IP strands were isolated, measuring 14 ± 4 mm in length and 417 ± 124 μm in width. The outer margin of IP was composed of two to three layers of fusiform parenchyma cells. The development of IP can be divided into five stages: 1) Locally IP starts its differentiation within a small segment of a broad cambial zone, at the cost of xylem differentiation. 2) Inward growth of IP advances, and fibres and sieve tubes differentiate. 3) IP is constricted by the encroachment of immature xylem cells between cambium and immature IP. 4) IP is isolated from the cambium and surrounded by immature, non-lignified xylem tissue. 5) IP is surrounded by lignified xylem tissue, and the fibres within IP become lignified.In all the phloem islands in a ten-year-old stem, sieve elements showed positive staining of callose with aniline blue. However, no staining of callose was observed in the external secondary phloem of agarwood trees collected from two different sites. No sieve tubes or sieve pores were detected by SEM observation of numerous serial cross and radial sections of the external phloem. We therefore conclude that sieve tubes are absent from the external phloem or extremely rare and that the transport of photosynthetic products in the stem of A. sinensis takes place in the interxylary phloem.
13
Bamne, Shrikrishna Nagorao. "Outcome of Height and BMI on Nerve Conduction Velocity in Patients Attending Index Medical College, Indore: A Cross-Sectional Study." International Physiology 5, no. 1 (2017): 35–38. http://dx.doi.org/10.21088/ip.2347.1506.5117.8.
Full text
14
Constantiou, Ioanna D., Anastasia Papazafeiropoulou, and Yogesh K. Dwivedi. "The Diffusion of Ip Telephony and Vendors’ Commercialisation Strategies." Journal of Information Technology 24, no. 1 (March 2009): 25–34. http://dx.doi.org/10.1057/jit.2008.29.
Full textAbstract:
The Internet telephony (IP telephony) has been presented as a technology that can replace existing fixed-line services and disrupt the telecommunications industry by offering new low-priced services. This study investigates the diffusion of IP telephony in Denmark by focusing on vendors’ commercialisation strategies. The theory of disruptive innovation is introduced to investigate vendors’ perceptions about IP telephony and explore their strategies that affect the diffusion process in the residential market. The analysis is based on interview data collected from the key market players. The study's findings suggest that IP telephony is treated as a sustaining innovation that goes beyond the typical voice transmission and enables provision of advanced services such as video telephony.
15
Durham, S. K., E. A. Dubovi, and W. L. Castleman. "The Role of Proteases in 4-ipomeanol-induced Enhancement of Sendai Viral Pneumonia in Mice." Veterinary Pathology 25, no. 3 (May 1988): 199–204. http://dx.doi.org/10.1177/030098588802500303.
Full textAbstract:
The ability of reconstituted, concentrated lyophilized lavage fluid to activate noninfectious Sendai virus (NISV) in vitro was examined. Lavage fluid was obtained from 4-ipomcanol (4-IP)-injured lungs at 1, 3, 5, 7, 9, and 13 days after treatment, and 1, 7, and 13 days after sham treatment (controls). Significantly higher viral titers were obtained using lavage fluid collected 1 day after 4-IP treatment. Higher protein concentrations were present in lavage fluid obtained at day 1 and 3 after 4-IP treatment. It is concluded that local viral-activating protease concentrations resulting from 4-IP-induced pulmonary injury is a likely microenvironmental modulator of paramyxoviral replication and can play an important role in paramyxoviral-induced lung injury.
16
TRAN, H., P. SALGADO, and P. LECOMTE. "Species, climate and fertilizer effects on grass fibre and protein in tropical environments." Journal of Agricultural Science 147, no. 5 (May 11, 2009): 555–68. http://dx.doi.org/10.1017/s0021859609008752.
Full textAbstract:
SUMMARYA 3-year experiment (2005–07) was conducted on Reunion Island (France) to evaluate the effect of species, climate and fertilization levels on fibre and protein fractions of tropical (C4; Chloris gayana and Pennisetum clandestinum) and temperate (C3; Dactylis glomerata and Lotium multiflorum) grasses. A near infrared reflectance spectroscopy (NIRS) prediction referential was developed to estimate neutral detergent fibre (NDF), acid detergent fibre (ADF), crude protein (CP), NDF insoluble protein (NDF-IP) and ADF insoluble protein (ADF-IP). The NIRS equations were then used to screen many regrowth grass samples collected at heading stage continuously for 3 years to evaluate their changes during the seasons. Results showed that grass species differed significantly in fibre and protein fractions. NDF, ADF and ADF-IP were the lowest in D. glomerata/L. multiflorum and the highest in C. gayana. The wet season was associated with higher NDF, ADF and NDF-IP in D. glomerata/L. multiflorum and lower NDF-IP in P. clandestinum. Fertilization increased the CP in C. gayana and the NDF-IP in P. clandestinum, but decreased the ADF-IP of both C. gayana and D. glomerata/L. multiflorum. Growth rate strongly changed NDF, ADF, NDF-IP and ADF-IP although no change in CP appeared. In general, NDF, ADF and NDF-IP increased with the growth rate. In contrast, the ADF-IP content decreased from slow to fast growth rate in C. gayana and D. glomerata/L. multiflorum. Growth rate changes were thus considered as a general indicator for fibre and protein fraction variations of these grasses.
17
Richard, Scott D., Paniti Sukumvanich, Jamie L. Lesnock, William C. McBee, Sushil Beriwal, Robert P. Edwards, Kristin K. Zorn, and Thomas C. Krivak. "Intraperitoneal Catheter Leads to Prolongation of the Time to Normalization of Serum CA125 Levels." International Journal of Gynecologic Cancer 20, no. 6 (July 2010): 932–35. http://dx.doi.org/10.1111/igc.0b013e3181e37a54.
Full textAbstract:
Objective:The intraperitoneal (IP) catheter has the potential to cause peritoneal irritation, which may contribute to an elevated CA125 level. We hypothesize that patients undergoing IP chemotherapy may have elevated CA125 values when compared with patients receiving intravenous (IV) chemotherapy.Methods:From February 2006 to July 2007, optimally debulked patients with stage III and stage IV ovarian carcinoma from a single institution were offered an outpatient IV/IP chemotherapy regimen modified from Gynecologic Oncology Group 172. They were matched to a cohort of similar patients who received IV paclitaxel and carboplatin. Demographic data and CA125 levels were collected before each cycle of chemotherapy and after the removal of the IP catheter. Statistical analysis was completed using a χ2 test with a significance level of P < 0.05.Results:Fifty patients received the standard IV regimen, and 38 patients completed the modified IV/IP regimen. There was no statistical difference in the median CA125 values between the 2 groups during the treatment. After 6 cycles of therapy, 68.4% (26/38) of the IP cohort had a normal CA125 level before IP catheter removal compared with 78% (39/50) in the IV chemotherapy cohort (P = 0.44). After removal of the IP catheter, 86.8% (33/38) of the patients had a normal CA125 value (68.4% vs 86.8%, P = 0.049).Conclusions:After removal of the IP catheter, an additional 18.2% (7/38) of patients in the IP group had normalized their CA125 level. Because CA125 levels at the end of the treatment have prognostic significance, the role of the IP catheter in an elevated CA125 level must be considered.
18
White, Mark A., Stanley J. Watowich, and Robert O. Fox. "Calibration of spiral-readout image-plate detectors." Journal of Applied Crystallography 32, no. 1 (February 1, 1999): 65–70. http://dx.doi.org/10.1107/s0021889898010474.
Full textAbstract:
An improved method for intensity-uniformity calibration of diffraction data collected on spiral-readout image-plate (IP) systems is described. This technique is applicable to all types of spiral-readout IP detectors. The procedure utilizes an attenuated direct-beam scan of the IP to generate a radial-sensitivity calibration table. Exposure and scanning of the calibration frame are done on the same time scale as typical data collections, and require no additional equipment. Specific examples are presented for use with Mac Science DIP2000 systems. The new radial calibration is shown to reduce significantly structure-basedRfactors. The improved radial calibration is also shown to lowerRmergewhen the IP is offset from the beam center. In addition to improving data quality and statistics, this method provides a quick and simple diagnostic tool to monitor changes in the sensitivity of the IP detector as a function of age.
19
Wang, Xue Bin, Pei Peng Liu, Cheng Long Li, and Qing Feng Tan. "Towards Measurement on the I2P Network." Applied Mechanics and Materials 427-429 (September 2013): 2223–28. http://dx.doi.org/10.4028/www.scientific.net/amm.427-429.2223.
Full textAbstract:
The I2P network has been widely used to protect user privacy via an open network of onion routers run by volunteers. To the best of our knowledge, the behavior of peers in the I2P network has not been well investigated in the existing researches. In this paper, we first present a simple and effective way to collect peers in the I2P network. Each day over 82% peers has been collected compared to the statistics from the statistics web site. With the data collected, we perform an empirical evaluation, revealing the phenomenon about IP address aliasing and identity aliasing. As identity aliasing makes bad impact on the availability and anonymity of the I2P network, we introduce family concept into the I2P network to mitigate the impact.
20
Minic, Snezana, Miljana Obradovic, Igor Kovacevic, and Dusan Trpinac. "Ocular anomalies in incontinentia pigmenti: Literature review and meta-analysis." Srpski arhiv za celokupno lekarstvo 138, no. 7-8 (2010): 408–13. http://dx.doi.org/10.2298/sarh1008408m.
Full textAbstract:
Introduction. Incontinentia pigmenti (IP) is an X-linked genodermatosis in which skin changes are combined with dental, eye and central nervous system anomalies. Objective. The goal of the study was to analyze ocular findings, IP minor criteria in available literature concerning IP cases published until now. Methods. We have done meta-analysis of 1931 IP patients found in 302 references published until 2010. Comparison of data published for the 1906-1976 and 1976-2010 periods was made. The collected data were mainly frequencies of ocular anomalies. Chi-square test was used to compare observed frequencies with their expectations. Results. Of total number of IP patients, 1,227 were ophthalmologically investigated. In 449 such patients 972 eye anomalies were registered, 2.16 anomalies per patient. Proportion of ophthalmologically investigated IP patients in the period 1906-1975 (70%) was higher than corresponding proportion (60%) for the period 1976-2010. For 1906-2010 period 36.5% IP patients with eye anomalies were diagnosed. The number of amaurotic eyes per patient did not significantly differ for the two periods (p=0.50; >0.05). The total number of eye anomalies per patient significantly differed for the same periods (p=0.00005; <0.05). Retinal anomalies were most frequent in both periods. Conclusion. This study suggests that IP is far more frequent than anyone could estimate. We believe that this study, covering 1906-2010 period, gives more reliable information about ophthalmological findings in IP; considering them as severe anomalies. Early detection and treatment of ophthalmological, neurological etc. findings may prevent severe consequences that IP may cause.
21
Lara, Primo N., Ronald Natale, John Crowley, Heinz Josef Lenz, Mary W. Redman, Jane E. Carleton, James Jett, et al. "Phase III Trial of Irinotecan/Cisplatin Compared With Etoposide/Cisplatin in Extensive-Stage Small-Cell Lung Cancer: Clinical and Pharmacogenomic Results From SWOG S0124." Journal of Clinical Oncology 27, no. 15 (May 20, 2009): 2530–35. http://dx.doi.org/10.1200/jco.2008.20.1061.
Full textAbstract:
Purpose Irinotecan plus cisplatin (IP) improved survival over etoposide plus cisplatin (EP) in Japanese patients with extensive-stage small-cell lung cancer (E-SCLC). To confirm those results and discern the potential role of population-related pharmacogenomics (PG) in outcomes, we conducted a large randomized trial of identical design to the Japanese trial in North American patients with E-SCLC. Patients and Methods Patients were randomly assigned to IP (irinotecan 60 mg/m2 on days 1, 8, and 15; cisplatin 60 mg/m2 day 1, every 4 weeks) or EP (etoposide 100 mg/m2 on days 1 through 3; cisplatin 80 mg/m2 day 1, every 3 weeks). Blood specimens for genomic DNA analysis were collected before random assignment in 169 patients. Results Of 671 patients, 651 were eligible (324 and 327 patients in the IP and EP arms, respectively). Response rates with IP and EP were 60% and 57%, respectively (P = .56). Median progression-free survival for IP and EP was 5.8 and 5.2 months, respectively (P = .07). Median overall survival for IP and EP was 9.9 and 9.1 months, respectively (P = .71). Severe diarrhea was more common with IP (19% v 3%); severe neutropenia and thrombocytopenia were higher with EP versus IP (68% v 33% and 15% v 4%, respectively). PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia. Conclusion This large North American trial failed to confirm the previously reported survival benefit observed with IP in Japanese patients. Both regimens produced comparable efficacy, with less hematologic and greater gastrointestinal toxicity with IP. These results emphasize the potential importance of PG in interpreting trials of cancer therapy.
22
Sharma, Rajan, H. D. Upadhyaya, S. V. Manjunatha, K. N. Rai, S. K. Gupta, and R. P. Thakur. "Pathogenic Variation in the Pearl Millet Blast Pathogen Magnaporthe grisea and Identification of Resistance to Diverse Pathotypes." Plant Disease 97, no. 2 (February 2013): 189–95. http://dx.doi.org/10.1094/pdis-05-12-0481-re.
Full textAbstract:
Blast, also known as leaf spot, caused by Pyricularia grisea (teleomorph: Magnaporthe grisea), has emerged as a serious disease affecting both forage and grain production in pearl millet in India. Pathogenic variation was studied in a greenhouse using 25 M. grisea isolates collected from four major pearl-millet-growing states in India (Rajasthan, Haryana, Maharashtra, and Uttar Pradesh) on 10 pearl millet genotypes (ICMB 02444, ICMB 02777, ICMB 06444, ICMB 93333, ICMB 96666, ICMB 97222, ICMB 99444, 863B, ICMR 06222, and ICMB 95444). Differential reactions to the test isolates were recorded on ICMB 02444, ICMB 93333, ICMB 97222, 863B, and ICMR 06222. The 25 isolates were grouped into five different pathotypes based on their reaction types (virulent = score ≥ 4 and avirulent = score ≤ 3 on a 1-to-9 scale). For the identification of resistance sources, a pearl millet mini-core comprising 238 accessions was evaluated under greenhouse conditions against five M. grisea isolates (Pg118, Pg119, Pg56, Pg53, and Pg45) representing the five pathotypes. Of 238 accessions, 32 were found to be resistant to at least one pathotype. Resistance to multiple pathotypes (two or more) was recorded in several accessions, while three accessions (IP 7846, IP 11036, and IP 21187) exhibited resistance to four of the five pathotypes. Four early-flowering (≤50 days) blast-resistant mini-core accessions (IP 7846, IP 4291, IP 15256, and IP 22449) and four accessions (IP 5964, IP 11010, IP 13636, and IP 20577) having high scores (≥7) for grain and green fodder yield potential and overall plant aspect were found to be promising for utilization in pearl millet improvement programs. Identification of five pathotypes of M. grisea and sources of resistance to these pathotypes will provide a foundation for breeding for blast resistance in pearl millet in India.
23
de Lassence, Arnaud, Jean-François Timsit, Muriel Tafflet, Élie Azoulay, Samir Jamali, François Vincent, Yves Cohen, Maïté Garrouste-Orgeas, Corinne Alberti, and Didier Dreyfuss. "Pneumothorax in the Intensive Care Unit." Anesthesiology 104, no. 1 (January 1, 2006): 5–13. http://dx.doi.org/10.1097/00000542-200601000-00003.
Full textAbstract:
Background The risk factors and outcomes of critically ill patients with iatrogenic pneumothorax (IP) have not been studied in a large unselected intensive care unit (ICU) population. Methods The authors studied a prospective cohort of adults admitted for more than 24 h. Data were collected at ICU admission and daily by senior physicians until ICU discharge. Risk factors for IP were identified in the entire cohort. A matched nested case-control study was used to evaluate the excess risk of IP in decedents. Results Of the 3,499 patients, 69 with pneumothorax before ICU admission were excluded. Of the remaining 3,430 patients, 94 experienced IP within 30 days (42 due to barotrauma and 52 due to invasive procedures). The cumulative incidence of IP was 1.4% (95% confidence interval [CI], 1.0-1.8) on day 5 and 3.0% (95% CI, 2.4-3.6) on day 30. Risk factors for IP (hazard ratio [95% CI]) were body weight less than 80 kg (2.4 [1.3-4.2]), history of adult immunodeficiency syndrome (2.8 [1.2-6.4]), diagnosis of acute respiratory distress syndrome (5.3 [2.6-11]) or cardiogenic pulmonary edema at admission (2.0 [1.1-3.6]), central vein or pulmonary artery catheter insertion (1.7 [1.0-2.7]), and use of inotropic agents during the first 24 h (2.1 [1.3-3.4]). Excess risk of IP in decedents was 2.6 (95% CI, 1.3-4.9; P = 0.004). Conclusion Iatrogenic pneumothorax is a life-threatening complication seen in 3% of ICU patients. Incorporating risk factors for IP into preventive strategies should reduce the occurrence of IP.
24
Ghasemzadeh, Peivand, Jamal A. Nazari, Mandana Farzaneh, and Gholamhossein Mehralian. "Moderating role of innovation culture in the relationship between organizational learning and innovation performance." Learning Organization 26, no. 3 (April 8, 2019): 289–303. http://dx.doi.org/10.1108/tlo-08-2018-0139.
Full textAbstract:
Purpose Different studies have analyzed the relationship between organizational learning (OL) and innovation performance (IP). However, the question of how innovation culture (IC) affects the relationship between OL and IP remains unexplored. This study aims to examine the impact of IC on the relationship between OL and various dimensions of IP, including product, process and objective innovation. Design/methodology/approach A research model was developed and performed based on the relevant literature in the field of OL, IC and IP. The hypotheses are tested with the data collected from companies operating in an intensive knowledge-based industry. Findings Based on the results of 625 questionnaires completed by pharmaceutical companies, OL activities and IC can result in product and process innovation. However, this relationship was not supported for the objective innovation. Furthermore, in terms of the moderating role of IC in the relationship between OL and IP dimensions, the results were significant. Practical implications The findings help to gain a better understanding of how organizational commitment by creating a culture for innovation can help to maximize the benefits of continuous OL in product and process innovation. Originality/value Considering the three aspects of IP, it is the first survey of the contribution of OL in firms’ IP with considering the moderating role of IC. The proposed model would enrich the relevant literature and provide us with better understanding how OL contributes to the IP.
25
Ji, Wen, and Yun Liu. "An Optimality-Theoretic Analysis of the Acquisition of English Sentence Stress Based on Acoustic Data." Complexity 2021 (March 25, 2021): 1–9. http://dx.doi.org/10.1155/2021/5553394.
Full textAbstract:
The present study adopts both empirical and theoretical methods for the analysis of the acquisition of English sentence stress based on Optimality Theory, aiming to overcome mispronunciation of English sentence stress. Optimality Theory has a dramatic impact on most areas in linguistics besides phonology. The acoustic software Praat is chosen to collect and label data as the basis of the empirical method. Then, through analyzing the four major principles of distribution of sentence stress (content words stressed principle, rightmost words stressed principle, leftmost words stressed principle, and new information priority principle) and based on the analysis of Optimality Theory, the software Praat, and SPSS, the researcher can present the following findings: firstly, the constraint hierarchical ranking of nonnative speakers is DEP-IO >> NEW-IP >> ALIGN-IP-LEFT >> ALIGN-IP-RIGHT. Secondly, the native speakers also undergo the demotion of constraint hierarchical ranking: NEW-IP >> DEP-IO >> ALIGN-IP-RIGHT >> ALIGN-IP-LEFT. Thirdly, the constraint in each demotion of constraint hierarchical ranking during different stages is as follows: NEW-IP constraint moves from the undominated position to the dominated position in the hierarchy; ALIGN-IP-RIGHT and ALIGN-IP-LEFT constraints move from the dominated position to the lower position in the hierarchy. Through the specific analysis, the researcher draws a conclusion that the varied reasons affect the nonnative speakers to master the distribution of sentence stress due to their incorrect position in the demotion of constraint hierarchical ranking.
26
Low, Chai Luan, George R. Bailie, Anne Evans, George Eisele, and Richard A. Venezia. "Pharmacokinetics of Once-Daily Ip Gentamicin in Capd Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 16, no. 4 (July 1996): 379–84. http://dx.doi.org/10.1177/089686089601600411.
Full textAbstract:
Objective This study aimed to investigate the pharmacokinetic characteristics of once-daily intraperitoneal (IP) gentamicin in continuous ambulatory peritoneal dialysis (CAPD) patients. Design Prospective, nonrandomized, open study. Setting CAPD outpatient clinic in a teaching hospital. Patients Ten volunteer CAPD patients without peritonitis. Interventions Each patient received a single IP dose of 0.6 mg/kg of gentamicin. Blood and dialysate samples were collected at 0,0.5,1, 2, 3,6 (end of first dwell), and 24 hours after the administration of IP gentamicin. Any urine produced over the 24hour study period was also collected. The dialysate concentration/time data were fitted to a monoexponential curve for all patients. Results The bioavailability was 56±11% over a six hour dwell. The mean serum elimination half-life (t1/2) was 35.8 hours. The volume of distribution was 0.23±0.08 L/kg. Equilibration of gentamicin across the peritoneal membrane was rapid, with a t½ equilibration of 4.5 hours. The peritoneal clearance was 5.74±1.5 mL/min. Patients with residual renal function had significantly higher systemic gentamicin clearances (7.36±1.46 mL/min) than those of anuric patients (4.76±1.08 mL/min, p < 0.024). Conclusion Currently recommended doses of oncedaily IP gentamicin for the treatment of peritonitis may not produce the desired therapeutic serum and dialysate concentrations over 24 hours for effective treatment of peritonitis.
27
Geller, Melissa Ann, Sarah A. Cooley, Mark Wallet, Bahram Valamehr, Deanna Gek Koon Teoh, Todd E. DeFor, Martin Felices, and Jeffrey Miller. "APOLLO: A phase I study of adaptive memory natural killer (NK) cells in recurrent ovarian cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 6044. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.6044.
Full textAbstract:
6044 Background: Human cytomegalovirus (CMV) infection induces a subset of long-lived CD57+NKG2C+ adaptive NK cells that exhibit enhanced antibody-dependent cellular cytotoxicity and resistance to tumor-suppressive mechanisms. We developed a 7-day culture process using a GSK3 inhibitor and IL-15 to manufacture modulated adaptive NK cells (FATE-NK100) from CMV+ haploidentical donors for adoptive transfer. The phase I Apollo trial tests the maximum tolerated dose/maximum feasible dose (MTD/MFD) of FATE-NK100 administered intraperitoneally (IP) to treat platinum-sensitive or -resistant recurrent ovarian, fallopian tube, and primary peritoneal cancer. Methods: FATE-NK100 via IP port was tested using 3 dose cohorts ([DC]; 1 × 107 cells/kg; >1 × 107 cells/kg to ≤3 × 107 cells/kg; or >3 × 107 to ≤10 × 107 cells/kg) after lympho-conditioning with fludarabine 25 mg/m2 IV and cyclophosphamide 300 mg/m2 IV on days −6 and −5. After FATE-NK100 infusion on day 0, rhIL-2 at 6 million IU was given IP 3 times a week for 6 doses for in vivo NK activation. IP fluid and peripheral blood were collected regularly until response assessment (day 28). Patients with stable disease or better were eligible for retreatment. Pre- and post-treatment tumor biopsies were collected. Results: Nine patients were treated with no dose-limiting toxicities (DLTs) to date. Retreatment based on clinical benefit was performed on 3 patients (33%), 2 following stable disease (DC 2) and 1 with partial remission (48% tumor reduction, DC 3). IP samples were collected for PK and functional analysis. FATE-NK100 product was detected by flow cytometry in 5 of 6 patients with evaluable samples (range 4.8%–91.2% donor NK cells at day +5-7). Retreatment samples were available in 1 patient, where FATE-NK100 persisted to day +21, demonstrating that repeated IP dosing did not accelerate clearance of the donor NK cells. In that same patient, measurement of NK cell CD107a degranulation or IFNg production in response to K562 targets demonstrated sustained enhanced in vivo function of FATE-NK100 compared to endogenous patient NK cells (e.g. at Day +12 CD107a+ NK were 39.0% vs. 22.5% cycle 1, and 40.3% vs. 18.2% retreatment cycle 2, and IFNg+ NK were 12.3% vs. 5.9% cycle 1, and 2.4% vs. 0.2% retreatment cycle 2). Conclusions: IP delivery of FATE-NK100 is safe, with clinical benefit in 3/9 patients treated. The allogeneic product cells persist and have enhanced function compared to patient NK cells for up to 21 days, even after retreatment. This phase I study in recurrent/refractory ovarian cancer shows promise for IP NK cell delivery. Clinical trial information: NCT00652899.
28
Alinaghi, Masoumeh, Duc Ninh Nguyen, Per Torp Sangild, and Hanne Christine Bertram. "Direct Implementation of Intestinal Permeability Test in NMR Metabolomics for Simultaneous Biomarker Discovery—A Feasibility Study in a Preterm Piglet Model." Metabolites 10, no. 1 (January 1, 2020): 22. http://dx.doi.org/10.3390/metabo10010022.
Full textAbstract:
Measurement of intestinal permeability (IP) is often used in the examination of inflammatory gastrointestinal disorders. IP can be assessed by measurement of urinary recovery of ingested non-metabolizable lactulose (L) and mannitol (M). The present study aimed to examine how measurements of IP can be integrated in a NMR-based metabolomics approach for a simultaneous quantification of L/M ratio and biomarker exploration. For this purpose, plasma and urine samples were collected from five-day-old preterm piglets (n = 20) with gastrointestinal disorders (subjected to intra-amniotic lipopolysaccharide (LPS, 1 mg/fetus)) after they had been administrated a 5% lactulose and 5% mannitol solution (15 mL/kg). The collected plasma and urine samples were analyzed by 1H NMR-based metabolomics. Urine L/M ratio measured by 1H NMR spectroscopy showed high correlation with the standard measurement of the urinary recoveries by enzymatic assays (r = 0.93, p < 0.05). Partial least squares (PLS) regressions and correlation analyses between L/M ratio and NMR metabolomics data revealed that L/M ratio was positively correlated with plasma lactate, acetate and succinate levels and negatively correlated with urinary hippuric acid and glycine. In conclusion, the present study demonstrated that NMR metabolomics enables simultaneous IP testing and discovery of biomarkers associated with an impaired intestinal permeability.
29
Orozco, Adrián Flores, Andreas Kemna, and Egon Zimmermann. "Data error quantification in spectral induced polarization imaging." GEOPHYSICS 77, no. 3 (May 1, 2012): E227—E237. http://dx.doi.org/10.1190/geo2010-0194.1.
Full textAbstract:
Induced polarization (IP) imaging is being increasingly used in near-surface geophysical studies, particularly for hydrogeologic and environmental applications. However, the analysis of IP data error has received little attention, even though the importance of an adequate error parameterization has been demonstrated for electrical resistivity imaging. Based on the analysis of data sets measured in the frequency range from 1 Hz to 1 kHz, we proposed a model for the quantification of phase data errors in IP measurements. The analyzed data sets were collected on an experimental tank containing targets of different polarizability. Our study is based on the common practice that the discrepancy of measurements taken in normal and reciprocal configuration can be considered as a measure of data error. Statistical analysis of the discrepancies between normal and reciprocal measurements revealed that the phase error decreases with increasing resistance (i.e., signal strength). We proposed an inverse power-law model to quantify the phase error as a function of the measured resistances. We found that the adequate implementation of the proposed error model in an inversion scheme leads to improved IP imaging results in laboratory experiments. Application to a data set collected at the field-scale also demonstrated the superiority of the new model over previous assumptions.
30
Parikh, Anish B., George Mellgard, Qian Qin, Vaibhav G. Patel, Bo Wang, Xiaobo Zhong, Amanda Leiter, et al. "Risk factors for emergency room and hospital care for patients with advanced solid tumors on immune checkpoint inhibitor therapy." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e15142-e15142. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15142.
Full textAbstract:
e15142 Background: Immune checkpoint inhibitors (ICIs) are increasingly utilized across cancer types. Risk factors for emergency room (ER) and inpatient (IP) care in this patient (pt) population remain poorly defined. Methods: We retrospectively reviewed charts for pts with (w/) advanced solid tumors who received more than 1 ICI dose at Mount Sinai from 1/1/11 – 4/28/17. Demographics, medical history, cancer diagnosis and therapy (tx) details, and outcomes were recorded. Descriptive data detailing ER/IP care during ICI tx (from first dose to 3 months after last dose) were collected. Fisher’s exact test and multivariable regression analyses were used to study differences between pts w/ versus w/out ER/IP care during ICI tx. Significance level was set at 0.05 for all tests. Results: 345 patients met the inclusion criteria for this study. Mean age was 64 years. Common tumor types were non-small cell lung cancer (n = 87), melanoma (n = 78), hepatocellular carcinoma (n = 53), and urothelial carcinoma (n = 38). 83% of patients had metastatic disease. Median duration of ICI tx was 2 months. During ICI tx, 50% received ER care and 43% received IP care, resulting in 369 total episodes of ER and/or IP care. 12% of episodes were attributed to ICI toxicity; 6% required intensive care. Median time to ER/IP care was 111 days. Median IP length of stay was 2 days. Several factors were found to be significant predictors of risk for ER or IP care on multivariable analysis (Table). African-American race and Hispanic ethnicity were each predictive of increased risk for both ER and IP care. Conclusions: ER/IP care is common among pts w/ advanced solid tumors on ICI tx. Understanding demographic and clinical risk factors can help prospectively identify higher-risk pts to inform preventive programs aimed at reducing such care. [Table: see text]
31
PAASI, JAAKKO, TUIJA LUOMA, KATRI VALKOKARI, and NARI LEE. "KNOWLEDGE AND INTELLECTUAL PROPERTY MANAGEMENT IN CUSTOMER–SUPPLIER RELATIONSHIPS." International Journal of Innovation Management 14, no. 04 (August 2010): 629–54. http://dx.doi.org/10.1142/s1363919610002805.
Full textAbstract:
The purpose of the paper is to empirically study firms' practises of knowledge and intellectual property (IP) management in customer–supplier relationships. The work applies the qualitative methodology of multiple case studies, and the material was collected in semi-structured interviews with management personnel at 36 organisations in Finland and in the Netherlands. Almost every firm had innovation relationships with their customers and suppliers, but the forms these relationships took, and the kinds of practices they involved, varied greatly. As a result, the firms considered the management of knowledge and IP in these relationships very challenging. We argue that by distinguishing knowledge management in the exploration phase of new business from knowledge management in the exploitation phase of innovation outcome, the firms could manage the knowledge and IP better. Accordingly, the paper introduces three propositions to support the knowledge and IP management in customer–supplier relationships.
32
Habidin, Nurul Fadly, Suzaituladwini Hashim, Nursyazwani Mohd Fuzi, and Mad Ithnin Salleh. "Total productive maintenance, kaizen event, and performance." International Journal of Quality & Reliability Management 35, no. 9 (October 1, 2018): 1853–67. http://dx.doi.org/10.1108/ijqrm-11-2017-0234.
Full textAbstract:
Purpose The purpose of this paper is to determine the relationship between total productive maintenance (TPM), kaizen event (KE) and innovation performance (IP) for Malaysian automotive industry using structural equation modeling (SEM). Design/methodology/approach The samples were selected from the list of Proton and Perodua automotive industry. The number of collected respondents was 238 respondents. An SEM technique was used in the study. In order to test the reliability and validity of the instrument, reliability analysis, exploratory and confirmatory factor analysis were conducted. Findings Based on the results, KE does not affect the relationship between TPM and IP. However, the impact of TPM on IP increases with mediating of KE for Malaysian automotive industry. Thus, this study has shown that empirical test results prove that the implementation of TPM and KE has improved the IP for Malaysian automotive industry. Research limitations/implications This study only focused on the Malaysian automotive industry. The other limitation in this research is the number of factors and limited measurement in this study. Only a few TPM, KE and IP measurements were considered. By using the SEM technique, four TPM constructs, three for KE constructs and three for IP measures were developed and verified. Therefore, this study can assist the researchers and practitioners to the practice of TPM, KE and IP for Malaysian automotive industry. Originality/value This research provides fundamental knowledge and direction for researchers in further research as well as practitioners to constantly improve IP through the implementation of TPM and KE for Malaysian automotive industry.
33
BALFAS, RODIAH, SUPRIADI SUPRIADI, T. L. MARDININGSIH, and ENDANG SUGANDI. "PENYEBAB DAN SERANGGA VEKTOR PENYAKIT KERITING PADA TANAMAN LADA." Jurnal Penelitian Tanaman Industri 8, no. 1 (July 15, 2020): 7. http://dx.doi.org/10.21082/jlittri.v8n1.2002.7-11.
Full textAbstract:
The cause of stunting disease of black pepper (Piper nigrum) in Indonesia has not yet been confirmed cither due o a virus or mycoplaam. However, similar disease found on black pepper plants in the Southeast Asia is caused by Piper yellow mottle virus (PYMV) which is transmitted by Planococcus citri. This expeiments was aimed o examine the cause of the stunting disease and its insect vectors. The expeiment were conducted from October 1998 to May 2001. Diseased vegetative materials of black pepper plants showing stunting disease were collected from Sukamulya, Sukabumi. The potential insect vectors were collected from black pepper plants in Bogor, IP Sukamulya (Sukabumi), Lampung and Bangka. The insects were fed on the diseased plants obtained from Lampung, Bogor and IP Sukamulya, then transferred o the healthy plants. The healthy plants were produced rom true seeds and cutings oiginated rom Bogor and IP Sukamulya. The tested plants were incubated at the green house and examined for disease development. Diseased leaf samples collected rom black pepper plant rom IP. Sukamulya and the transmitted plants were sent to the University of Minnesota, USA for Ihe virus (PYMV) by using ISEM (immunosorbent electron microscope). The result snowed that the leaves samples rom IP. Sukamulya were infected by PYMV. The morphology and size of the virus were similar to those caused stunting disease in the South East Asia. Potential insects vectors found on the diseased black <br /><br />pepper plants were two mealybugs, P. minor and Ferrisia virgata (Hemiptera; Coccoidca: PaaidbcoccidaeX aa well as an aphid Toxoptera aurantii (Hemiptera: Aphidoidea: Aphididae). The first tial on disease transmission by using P. minor, previously reared on the potato tubers, showed one out of ten tested plants produced disease sympom. The subsequent trial using P minor, bred on healthy black pepper seedlings, showed thee out often tested plants developed disease symptoms. None of the aphid transmitted plants developed Ihe disease. This study confirmed thai PYMV b the cause of stunting disease on black pepper in IP Sukamulya and Lampung and P. minor as the insect vecor of the disease.<br /><br />
34
LOW, CHAI LUAN, KAMANI GOPALAKRISHNA, and WAI CHOONG LYE. "Pharmacokinetics of Once Daily Intraperitoneal Cefazolin in Continuous Ambulatory Peritoneal Dialysis Patients." Journal of the American Society of Nephrology 11, no. 6 (June 2000): 1117–21. http://dx.doi.org/10.1681/asn.v1161117.
Full textAbstract:
Abstract. This study determined the pharmacokinetic characteristics of once daily intraperitoneal (IP) cefazolin in continuous ambulatory peritoneal dialysis (CAPD) patients. Each of the 10 volunteer CAPD patients without active peritonitis received a single IP dose of 1 g of cefazolin sodium for a 6-h dwell. All patients underwent a fixed CAPD regimen comprising a first 6-h dwell followed by two 3-h dwells and a final 12-h overnight dwell. Blood and dialysate samples were collected at 0, 0.5, 1, 2, 3, 6 (end of first dwell), and 24 h after the administration of IP cefazolin. Any urine produced was collected over the 24-h study period. A validated HPLC method was used to analyze cefazolin in plasma, dialysate, and urine. The bioavailability was found to be 77.9 ± 3.1%, volume of distribution 0.20 ± 0.05 L/kg, and plasma half-life 39.9 ± 25.4 h. Mean total, renal, and peritoneal clearances were 4.5 ± 2.3, 1.4 ± 1.1, and 3.5 ± 1.8 ml/min, respectively. Mean plasma and dialysate concentrations at 24 h were 42.8 ± 14.3 and 31.8 ± 11.7 mcg/ml, respectively, well above the minimum inhibitory concentrations (MIC) of susceptible organisms. A once daily IP cefazolin dose of 500 mg/L gave desirable pharmacokinetic attributes for use as a suitable alternative to vancomycin for empiric treatment of CAPD-associated peritonitis.
35
Krasner, C. N., M. V. Seiden, A. F. Fuller, M. Roche, C. L. Verrill, F. D’Amato, O. Tretyakov, K. Tyburski, U. A. Matulonis, and J. G. Supko. "Pharmacokinetic analysis of an all intraperitoneal carboplatin and paclitaxel regimen in ovarian cancer patients demonstrates favorable systemic bioavailability of both agents." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 5008. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5008.
Full textAbstract:
5008 Background: A phase III trial (GOG172) demonstrated improved survival for patients with newly diagnosed and optimally debulked ovarian cancer treated with intraperitoneal (ip) cisplatin and paclitaxel (P), given both as a 24 h iv infusion and ip, as compared with standard iv dosing. Studies to further enhance efficacy and minimize toxicity of ip taxane/platinum regimens are needed. Because adequate systemic drug exposure is thought to be essential for maximum therapeutic benefit of ip chemotherapy, the pharmacokinetics (PK) and bioavailability of ip P and carboplatin (C) were determined in this pt population in a phase II trial to evaluate dosing by the ip route alone. Methods: P 60 mg/m2 once a week and C at an AUC 6 every weeks were infused over 1 h, iv in cycle 1 and ip in the 5 subsequent 21-day cycles. Plasma samples were collected during week 1 of cycles 1, 2 and 6. P was measured by LC/MS and free platinum (fPt) was determined by flameless atomic absorption. Results: PK data is available for 14 pts receiving at least 1 cycle of ip therapy and for 7 pts who received all 5 cycles. When given ip, P achieved a peak conc. in plasma (Cmax) of 0.086 ± 0.034 μM (mean ± SD) at 6.4 ± 2.2 h, 22-times lower than Cmax for iv infusion (1.92 ± 0.80 μM). Thereafter, P plasma levels were comparable for both routes and decayed at similar rates with a half-life of 13.9 ± 4.1 h for iv and 13.7 ± 2.2 h for ip dosing. The systemic bioavailability of ip P was 53 ± 19% for the initial dose and 46 ± 10% in cycle 6. P plasma levels exceeded 0.05 μM, the pharmacologic threshold conc., for >20 h upon ip dosing in 67% (10/15) and 71% (5/7) of pts in cycles 2 and 6, respectively. C was rapidly absorbed into systemic circulation when given ip with a Cmax of 83 ± 11 μM for fPt at 1.6 ± 0.2 h in cycle 2. Consistent with prior reports, systemic availability of fPt exceeded 100% (133 ± 22% in cycle 2; 142 ± 47% in cycle 6). Conclusions: Weekly ip P 60 mg/m2 with ip C (AUC 6) every 3 weeks achieved a potentially effective pattern of systemic exposure to both agents in a majority of pts. The cumulative time that P plasma levels are >0.05 μM per cycle of therapy is likely to be longer than provided by the iv/ip dosing regimen for P (135 mg/m2 24 h iv infusion day 1; 60 mg/m2 ip day 8) used in GOG172. No significant financial relationships to disclose.
36
Valmohammadi, Changiz, Javad Sofiyabadi, and Bahare Kolahi. "How do Knowledge Management Practices Affect Sustainable Balanced Performance? Mediating Role of Innovation Practices." Sustainability 11, no. 18 (September 19, 2019): 5129. http://dx.doi.org/10.3390/su11185129.
Full textAbstract:
The main purpose of this study is to investigate the mediating role of innovation practices (IP) amidst relations of knowledge management practices (KMP) and sustainable balanced performance (SBP). Furthermore, this research illustrates a comprehensive empirical study in the Iranian knowledge-based industrial companies that are the manufacturers of advanced machineries and equipment. First- and second-order exploratory factor analysis (EFA) was done to confirm constructs validity. Then, relations among variables were studied by applying the partial least squares (PLS) technique to collected data from 104 industrial knowledge-based companies. The results obtained from the analysis supported all the research hypotheses. KPM significantly and strongly affects IP and SBP. Also, IP mediates the relations between KPM and SBP in industrial knowledge-based firms.
37
Zabini, Diana, Akos Heinemann, Vasile Foris, Chandran Nagaraj, Patrick Nierlich, Zoltán Bálint, Grazyna Kwapiszewska, et al. "Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients." European Respiratory Journal 44, no. 4 (July 17, 2014): 951–62. http://dx.doi.org/10.1183/09031936.00145013.
Full textAbstract:
Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with chronic inflammation but the pathological mechanisms are largely unknown. Our study aimed to simultaneously profile a broad range of cytokines in the supernatant of pulmonary endarterectomy (PEA) surgical material, as well as prospectively in patients with CTEPH to investigate whether circulating cytokines are associated with haemodynamic and physical characteristics of CTEPH patients.Herein, we show that PEA specimens revealed a significant upregulation of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-γ-induced protein-10 (IP)-10, macrophage inflammatory protein (MIP)1α and RANTES compared to lung tissue from healthy controls.In prospectively collected serum, levels of IL-6, IL-8, IP-10, monokine induced by interferon-γ (MIG) and MIP1α were significantly elevated in CTEPH patients compared to age- and sex-matched healthy controls. In serum of idiopathic pulmonary arterial hypertension (IPAH) patients, only IP-10 and MIG were significantly increased. In CTEPH but not in IPAH, IP-10 was negatively correlated with cardiac index, 6-min walking distance and carbon monoxide diffusion capacity. In vitro, IP-10 significantly increased migration of freshly isolated adventitial fibroblasts.Our study is the first to show that IP-10 secretion is associated with poor pulmonary haemodynamics and physical capacity in CTEPH and might be involved in the pathological mechanism of PEA tissue formation.
38
Elwell, Rowland J., Reginald F. Frye, and George R. Bailie. "Pharmacokinetics of Intraperitoneal Cefepime in Automated Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 25, no. 4 (July 2005): 380–86. http://dx.doi.org/10.1177/089686080502500414.
Full textAbstract:
Objective This study determined the pharmacokinetics of intraperitoneal (IP) cefepime in automated peritoneal dialysis (APD) patients. Design and Methods A prospective pharmacokinetic study was performed in 6 noninfected adult APD patients. All patients were administered a single IP dose of cefepime (15 mg/kg) over a 6-hour dwell. Patients then underwent a fixed APD regimen consisting of the first 6-hour dwell, followed by an 8-hour dialysate-free period and a subsequent series of 3 overnight APD exchanges. Blood and dialysate samples were collected at t = 0, 1, 2, 4, 6 (end of dwell), and 24 hours. Any urine produced during the study period was collected. Cefepime concentrations in serum, dialysate, and urine were determined by liquid chromatography mass spectrometry. Pharmacokinetic parameters were calculated assuming a mono-exponential model. Results One hour after IP administration, serum cefepime levels exceeded the minimum inhibitory concentration (8 μg/mL) for susceptible organisms. The mean serum and dialysate concentrations at 24 hours were 15.8 ± 3.6 and 6.2 ± 2.3 μg/mL respectively. Bioavailability was 84.3% ± 6.2%, volume of distribution 0.34 ± 0.07 L/kg, and serum half-life 13.8 ± 3.2 hours. Total, peritoneal, and renal clearances were 16.5 ± 4.4, 4.3 ± 0.7, and 3.5 ± 2.5 mL/minute, respectively. Conclusions IP cefepime dosed at 15 mg/kg resulted in adequate serum concentrations in APD patients at 24 hours post dose. Pharmacokinetic predictions suggest that most APD and CAPD patients would achieve adequate serum cefepime concentrations if treated with standard doses of 1000 mg given IP once daily. Patients using APD regimens different from that used in this study, anuric patients, and those with significant residual renal function may require a more individualized approach.
39
Obringer, Amy R., Justine K. O'Brien, Robin L. Saunders, Kazutoshi Yamamoto, Sakae Kikuyama, and Terri L. Roth. "Characterization of the spermiation response, luteinizing hormone release and sperm quality in the American toad (Bufo americanus) and the endangered Wyoming toad (Bufo baxteri)." Reproduction, Fertility and Development 12, no. 2 (2000): 51. http://dx.doi.org/10.1071/rd00056.
Full textAbstract:
Spermiation and LH release in response to several methods of LHRH administration were assessed in the American toad (Bufo americanus), and the most successful method was tested in the endangered Wyoming toad (Bufo baxteri). Specific objectives were to: (1) compare spermiation responses and plasma LH concentration after invasive and non-invasive LHRH treatments; (2) evaluate sperm production in response to different LHRH dosages; (3) characterize the timing of sperm release post LHRH treatment; and (4) assess sperm quality (motility, viability, morphology and acrosomal status). Male American toads were administered 4 g LHRH by one of four routes: (1) intraperitoneal injection (IP); (2) subcutaneous injection (SQ); (3) dorsal dermis absorption (DDA); and (4) ventral dermis absorption (VDA). Aspermic urine only was collected from saline-treated controls and DDA animals. Several VDA animals released spermic urine; however, all LHRH-injected toads released spermatozoa. IP animals produced higher sperm and LH concentrations than SQ animals. The spermiation response in animals treated IP with 1 g LHRH was similar to that in animals treated with 4 g, but lower LHRH dosages tested produced inferior responses. Sperm production in responsive animals increased over time during the 12-h sampling interval. Regardless of treatment, most American toad spermatozoa were motile, viable, and acrosome-intact. Endangered Wyoming toads were treated IP with 4 g LHRH, and spermic urine was collected. Although most spermatozoa were viable and acrosome-intact, a considerable percentage possessed structurally abnormal heads. A single IP injection of LHRH appears to be a reliable and safe method for controlling spermiation in toads and may be useful for assisting endangered amphibian propagation.
40
Liu, Zhengqiao, Yongzhong Jiang, Zhu Yao, Xiliang Liu, Li Zhao, and Xianchun Zhang. "Congruence in career calling and employees’ innovation performance: work passion as a mediator." Chinese Management Studies 15, no. 2 (February 8, 2021): 363–81. http://dx.doi.org/10.1108/cms-12-2019-0427.
Full textAbstract:
Purpose Based on self-consistency theory and conservation of resource theory, this study aims to discuss the impact of career calling congruence on employees’ innovation performance (IP) and analyzes the mediating effect of work passion [harmonious passion (HP) and obsessive passion (OP)]. Design/methodology/approach To avoid serious common method biases, data in this paper were collected at three-wave. This paper investigated 381 employees to assess their career calling in time 1, measured their work passion in time 2 and assessed the IP of these employees in time 3. This paper also conducts confirmatory factor analysis, polynomial regression, response surface analysis, bootstrapping test and simple slope test to verify the research hypothesis in this paper. Findings In the career calling congruence case, employees’ HP, OP and IP are higher when both levels of serving oneself career calling and helping others career calling are high than when both are low; In the career calling incongruence case, employees’ HP, OP and IP are higher in the “low serving oneself and high helping others” case than in the “high serving oneself and low helping others” case; The more congruent the “serving oneself” and “helping others” career calling are, the higher the employees’ HP, OP and IP will be; and HP and OP mediate the relationship between career calling congruence and IP. Originality/value This study further clarifies the structure of career calling and find the positive effects of career calling on IP. The results present a deeper understanding of career calling and are universal applicable to the eastern culture context.
41
Kim, So, and Eungdo Kim. "How Intellectual Property Management Capability and Network Strategy Affect Open Technological Innovation in the Korean New Information Communications Technology Industry." Sustainability 10, no. 8 (July 24, 2018): 2600. http://dx.doi.org/10.3390/su10082600.
Full textAbstract:
This paper analyses factors in open innovation activity in the Korean new information and communications technology (ICT) industry, with a focus on cooperation network strategy and intellectual property (IP) management capability, by applying multiple regression models with data collected from 300 companies within the industry. The results of this analysis suggested that the intensity and variation of a company’s technological cooperation with a new ICT company has a statistically meaningful impact on its innovation. In particular, the impact depended on the type of cooperation network. Though IP management capability was also shown to have an important influence on a new ICT company’s innovation, the impact of specific actions for IP management varied by the specific type of innovation results. This study suggests that new ICT companies need to construct technological innovation networks using multiple external sources and enhance their IP management capability in order to increase their technological innovation performance. The factors influencing technological innovation are elements of open innovation, indicating the open technological innovativeness of the new ICT Industry.
42
Aizawa, M., S. Mitsunaga, H. Okuyama, K. Nakachi, I. Ohno, S. Shimizu, H. Takahashi, T. Okusaka, A. Ochiai, and M. Ikeda. "Association of hypophosphatemia-occurring sorafenib with prognosis and hepatic impairment in patients with advanced hepatocellular carcinoma." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 188. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.188.
Full textAbstract:
188 Background: Hypophosphatemia is observed during sorafenib treatment. At the increased metabolic demand of the liver, hypophosphatemia is considered to be associated with a good clinical course. Hypophosphatemia associated with sorafenib treatment may also be a favorable event, but this has not yet been elucidated. The aim of this study was to evaluate the clinical significance of hypophosphatemia developing during sorafenib treatment for advanced hepatocellular carcinoma (HCC). Methods: The data of 41 advanced HCC patients (median age: 68 years, female/male: 4/37, HBs-Ag(+)/HCV-Ab(+):10/22) who received sorafenib treatment (800 mg, daily) for more than 30 days were reviewed. There were 27 and 14 patients with Child-Pugh class A and B. UICC stage II/III/IV was observed in 13/10 /18 patients. Clinical data, including those on the serum level of inorganic phosphate (IP), were collected before and after 30 days of sorafenib treatment. Overall survival time (OS) was calculated from the start of sorafenib treatment. The significance level was set at p<0.05. Results: Mean serum IP level before sorafenib treatment was 3.2mg/dL (range 2.4-4.5). After 30 days treatment, IP level was decreased (mean 2.6mg/dL, range 1.3-3.9), compared to that at pre-treatment (p<0.001). The patients in whom the serum IP was less than 2.4mg/dL at 30 days was assigned to the decreased IP group (N=14, mean IP 2.1mg/dL, range1.3-2.3). The decreased IP group showed a better prognosis (no event of death during the observation time) than the nondecreased IP group (MST 286 days, p=0.024). In the non-decreased IP group, the serum Alb (mean 3.6g/dL) and T.Bil (mean 0.8mg/dL) were worse after 30 days treatment (Alb 3.4g/dL p=0.007, T.Bil 1.1mg/dL p=0.037). However, deterioration of Alb (mean 3.7 vs. 3.6g/dL p=0.505) and T.Bil (mean 0.7 vs. 0.8mg/dL p=0.404) could be avoided in the decrease IP group. Conclusions: Hypophosphatemia occurring during sorafenib treatment for advanced HCC was associated with a favorable prognosis. The serum Alb and T.Bil levels were indicators of liver function and were preserved in patients with decreased serum levels of phosphate. No significant financial relationships to disclose.
43
Ip, Edward H., Phillip Leung, and Joseph Johnson. "Interactive Profiler: An Intuitive, Web-Based Statistical Application in Visualizing Educational and Marketing Databases." Journal of Educational and Behavioral Statistics 29, no. 2 (June 2004): 157–75. http://dx.doi.org/10.3102/10769986029002157.
Full textAbstract:
We describe the design and implementation of a web-based statistical program—the Interactive Profiler (IP). The prototypical program, developed in Java, was motivated by the need for the general public to query against data collected from the National Assessment of Educational Progress (NAEP), a large-scale US survey of the academic state of American students. The emphasis of the program requirements is on bringing the NAEP data to a broader and not necessarily technically prepared audience. We show that the IP is an intuitive tool for visualizing students’ profiles. Because the same principles for visualization apply to other databases, in this article we also demonstrate how IP can be used to visualize a large marketing database. Besides NAEP, our statistical visualization tool should be pertinent to other federally maintained databases and large-scale marketing databases.
44
Hu, Bing Yi, Hua Liang Teng, Xue Feng Zhang, Lu Bai, and Kai Fan Wu. "An IP Based Audio Test Network for Tunnel Application." Applied Mechanics and Materials 568-570 (June 2014): 441–47. http://dx.doi.org/10.4028/www.scientific.net/amm.568-570.441.
Full textAbstract:
An accurate measurement of noise wave is the key to effective noise control in a tunnel. In this paper, an IP based audio test network is presented. This network includes 100 battery powered recorders and a WIFI network. Each recorder can acquire 2 channels of audio waves and be triggered by external signals of infrared or electrical synchronic pulse. A main control computer connects these recorders to setup parameters and collect data via the WIFI network. Sensors are reassembled to be compatible with the interface of standard sound source. Meanwhile each sensor is fixed in a sensor holder, which can be placed to any position on a plane and can be used to adjust its sensor to 0-180 degrees in both of X-Y direction. The sound source generates various signals, such as clicks, tones, and tone bursts, to help understand how the sound propagates in tunnels. This designed network is capable of acquiring multipoint sound waves synchronously.
45
Buoye, Alexander, Arne De Keyser, Zeyang Gong, and Natalie Lao. "Intellectual property extensions in entertainment services: Marvel and DC comics." Journal of Services Marketing 34, no. 2 (February 13, 2020): 239–51. http://dx.doi.org/10.1108/jsm-06-2019-0224.
Full textAbstract:
Purpose The purpose of this paper is to look into the topic of IP category extensions in an entertainment setting. The main goal of the study is to explore the reciprocal spillover effect of customer experience (CX) ratings with an intellectual property (IP) in one medium (i.e. film) on the sales of the same IP in other media (i.e. comic books). Design/methodology/approach The study is based on 21-years of monthly top 300 comic book direct market sales data linked to the release schedule and domestic box office gross figures for films featuring Marvel and DC comic book IP appearing in the weekly top 50 films over the same time period. The analysis is based on a hierarchical linear (i.e. mixed) model to account for the nested structure of the data. Findings The analysis reveals that CX ratings of weekly top 50 films featuring comic book IP have a quadratic relationship with comic book sales by the two major publishers. Films receiving very good but not excellent ratings are associated with the highest levels of incremental comic book sales. Research limitations/implications The model is based on sales of periodical comic books in the direct market only (i.e. specialty shops) and does not account for sales of digital comics or collected editions through other channels. The analysis is also limited to IP for the two major publishers (Marvel and DC comics). Originality/value This study expands current knowledge on CX spillover effects between different media, contributing to entertainment and CX-literature alike.
46
Awtrey, C. S., K. E. Greenawalt, J. M. Colt, R. L. Corazzini, M. Philbrook, M. R. Santos, and R. E. Bristow. "Tissue levels of cisplatin in previously traumatized tissue without adhesion formation in a rabbit sidewall adhesion and intraperitoneal delivery model." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 5525. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.5525.
Full textAbstract:
5525 Background: It has been hypothesized that the presence of extensive adhesions after ovarian cancer resection may limit the distribution of intraperitoneal (IP) chemotherapeutics. The objective of this study was to determine if using a hyaluronate/carboxymethylcellulose (HA/CMC) barrier to prevent adhesions during a simulated tumor resection surgery would increase tissue drug levels following subsequent IP chemotherapy. Methods: A sidewall defect/cecal abrasion model was used to induce adhesion formation and simulate tumor resection trauma in 22 rabbits. Seven rabbits received HA/CMC at the end of the surgery. Four weeks after surgery, cisplatin (2.5mg/kg) was administered IP to HA/CMC treated and untreated animals or IV to untreated controls. Animals were sacrificed 24hrs after infusion and tissue samples were collected from inside the defect (with or without adhesions) and outside the defect on the contralateral sidewall. Samples were cryosectioned and analyzed for platinum content by ICP/MS. Results: Platinum tissue levels in the uppermost peritoneal layer (0–1mm) were significantly higher for IP delivery than IV and were the highest for IP delivery when no adhesions were present inside the defect. Platinum levels were significantly higher in the previously traumatized tissue inside the defect than in untraumatized tissue outside the defect. This was consistent for both IP or IV and HA/CMC treated or untreated animals. The benefit of HA/CMC was underscored by the fact that samples under adhesions could not be obtained for that group due to the significant reduction in adhesion formation compared to untreated controls. Conclusions: Recently traumatized tissue without adhesions had the highest platinum levels following IP cisplatin in this model. The previously traumatized tissue had significantly higher platinum levels than untraumatized tissue likely due to both increased peritoneal diffusion and systemic delivery components. [Table: see text] [Table: see text]
47
Tang, Nelson Leung-Sang, Paul Kay-Sheung Chan, Chun-Kwok Wong, Ka-Fai To, Alan Ka-Lun Wu, Ying-Man Sung, David Shu-Cheong Hui, Joseph Jao-Yiu Sung, and Christopher Wai-Kei Lam. "Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome." Clinical Chemistry 51, no. 12 (December 1, 2005): 2333–40. http://dx.doi.org/10.1373/clinchem.2005.054460.
Full textAbstract:
Abstract Background: Exaggerated activation of cytokines/chemokines has been proposed as a factor in adverse outcome of severe acute respiratory syndrome (SARS). Previous studies on chemokines have included only small numbers of patients, and the utility of plasma chemokines as prognostic indicators is unclear. Methods: We studied 255 archival plasma samples collected during the first or second week after disease onset. The chemokines interferon-inducible protein-10 (IP-10), monokine induced by interferon-γ (MIG), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation normal T cell expressed and secreted (RANTES) were measured by cytometric bead array with a 4-color FACSCalibur flow cytometer. Reverse transcription and real-time quantitative PCR and immunohistochemical staining were performed to analyze the production of IP-10 in lung tissue at autopsy. Conditional logistic regression was used to identify independent predictors for adverse disease outcome. Results: Increases in IP-10, MIG, and IL-8 during the first week after onset of fever were associated with adverse outcome (intensive care unit admission or death) in the univariate analysis. During the second week, only MIG concentration was associated with prognosis. After adjusting for other risk factors, plasma IP-10 concentration at the first week remained as an independent prognostic factor, with an odds ratio for adverse outcome of 1.52 (95% confidence interval, 1.05–2.55) per fold increase in plasma IP-10 concentration above the median. During the second week, chemokines provided little independent prognostic information. IP-10 was increased in lung tissue from patients who died of SARS. Conclusions: Increased plasma IP-10 during the first week of SARS symptoms is an independent predictor of outcome. Chemokine activation may be an early event in SARS, and an exaggerated host response may produce complications.
48
Roberts, Darren M., Dwarakanathan Ranganathan, Steven C. Wallis, Julie M. Varghese, Adrian Kark, Jeffrey Lipman, and Jason A. Roberts. "Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 36, no. 4 (July 2016): 415–20. http://dx.doi.org/10.3747/pdi.2015.00008.
Full textAbstract:
Background The standard treatment of peritoneal dialysis (PD)-associated peritonitis (PD-peritonitis) is intraperitoneal (IP) administration of antibiotics. Only limited data on the pharmacokinetics and appropriateness of contemporary dose recommendations of IP cefalothin and cefazolin exist. The aim of this study was to describe the pharmacokinetics of IP cefalothin and cefazolin in patients treated for PD-peritonitis. Methods As per international guidelines, IP cefalothin or cefazolin 15 mg/kg once daily was dosed with gentamicin in a 6-hour dwell to patients with PD-peritonitis during routine care. Serial plasma and PD effluent samples were collected over the first 24 hours of therapy. Antibiotic concentrations were quantified using a validated chromatographic method with pharmacokinetic analysis performed using a non-compartmental approach. Results Nineteen patients were included (cefalothin n = 8, cefazolin n = 11). The median bioavailability for both antibiotics exceeded 92%, but other pharmacokinetic parameters varied markedly between antibiotics. Both antibiotics achieved high PD effluent concentrations throughout the antibiotic dwell. Cefazolin had a smaller volume of distribution compared with cefalothin (14 vs 40 L, p = 0.003). The median trough total plasma antibiotic concentration for cefazolin and cefalothin during the dwell differed (plasma 56 vs 13 mg/L, p < 0.0001) despite a similar concentration in PD effluent (37 vs 38 mg/L, p = 0.58). Lower antibiotic concentrations were noted during PD dwells not containing antibiotic, particularly cefalothin, which was frequently undetectable in plasma and PD effluent. The median duration that the unbound antibiotic concentration was above the minimum inhibitory concentration (MIC) was approximately 13% (plasma) and 25% (IP) for cefalothin, and 100% (plasma and IP) for cefazolin, of the dosing interval. Conclusions When IP cefalothin or cefazolin is allowed to dwell for 6 hours, sufficient PD effluent concentrations are present for common pathogens during this time. However, with once-daily IP dosing, in contrast to cefazolin, there is a risk of subtherapeutic plasma and PD effluent cefalothin concentrations, so more frequent dosing may be required.
49
Singh, Noopur. "Strategic human resource practices for innovation performance." Benchmarking: An International Journal 25, no. 9 (November 29, 2018): 3459–78. http://dx.doi.org/10.1108/bij-08-2017-0215.
Full textAbstract:
PurposeThe purpose of this paper is to understand the conception of strategic human resource practices (SHRPs) for establishing innovation performance (IP) in the tourist hotel industry. In this research, the author has also studied the influence of knowledge management capacity (KMC) as a mediator between the two and the role of environmental uncertainty (EU) in moderating the relation between SHRP and KMC.Design/methodology/approachData were collected through survey method from the employees and managers of the tourist hotels in Jharkhand, India. Furthermore, 368 customer contact employees and 46 managers’ responses were analyzed using confirmatory factor analysis and SPSS macro named PROCESS.FindingsThe interpretation of the empirical results signifies SHRP influence on IP and KMC as a mediator between SHRP and IP. Additionally, the role of EU in positively mitigating the interaction between SHRP and KMC was seen.Originality/valueThe present research work adds to the subsisting literature by empirically fortifying the proposed hypotheses. Additionally, current studies focused on hospitality and tourism industry operating in a developed economy, the present study is an attempt to explore a comprehensive and theoretically grounded relationship between SHRP, KMC and IP with the help of resource-based view in an emerging economy.
50
Hachem, Hilal, David Levitz, Danai Dima, Joshua R. Dower, Rabiah B. Fresco, Ruth Ann Weidner, Rachel J. Buchsbaum, John Kalil Erban, and Susan K. Parsons. "Contemporary use of inpatient antineoplastic (IP) treatment (Rx): Who is getting care and why?" Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e18015-e18015. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e18015.
Full textAbstract:
e18015 Background: The steady trend towards outpatient antineoplastic medication delivery has been spurred by improvements in supportive care, innovations in drug delivery, and financial considerations. Despite these trends, a significant number of patients (pts) continue to receive IP Rx for both hematological (HM) and solid cancers (ST). The purpose of this study is to describe a single center’s experience with IP Rx between 01/01/2015 and 12/31/2017. Methods: All pts ( > 18yo) who received IP Rx for a cancer diagnosis, exclusive of stem cell transplantation, were identified from hospital pharmacy records. Patient and disease characteristics were collected at the index (initial) admission. All pts were followed for 1 year after index admission for 30-day readmission and subsequent admissions for IP Rx. Reasons for IP Rx included: urgent/emergent initiation of Rx; high acuity inpatient management for ST (e.g., intraperitoneal, intra-arterial, intravesical therapy) or complex HM regimen; ongoing Rx; palliation. Results: A total of 266 index admissions were identified with 66.2% of pts having a HM (n = 176) and 33.8% having a ST (n = 90). IP Rx was classified as urgent for 48.1% of pts (n = 128); 70.3% (n = 90) of these admissions were new diagnoses of which 91.4% (n = 86) were HM. High acuity IP management was required for 37.5% of pts (n = 100) (47% for ST (n = 47) and 53% for HM (n = 53)). The remaining index admissions were classified as ongoing Rx for 4.5% of pts (n = 12) and palliation for 9.8% (n = 26). Pts with ST required intensive care significantly more often than pts with HM (57.8% vs. 15.9%, p < 0.001) but with no difference in inpatient mortality (4.4% vs. 5.7%, p = 0.891). The 30-day readmission rate was 32.2% for ST and 25.6% for HM (p = 0.515). After the index admission, 10% of ST pts and 60.2% of HM pts had at least 1 subsequent admission for IP Rx (p < 0.001). Conclusions: In this 3-year retrospective review, the vast majority of pts receiving IP Rx required either urgent initiation of care or high acuity care, currently only available in the inpatient setting. While there is little evidence of routine IP Rx or opportunity, at present, to transition further care to the outpatient setting, the high rates of 30-day readmission warrant further evaluation.