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Dissertations / Theses on the topic 'Colon (Anatomy)'

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Published: 4 June 2021
Last updated: 29 July 2024

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1

Pedersen, Katherine Lynn. "Comparison of colorectal cancer screening practices between rural and urban providers." Menomonie, WI : University of Wisconsin--Stout, 2005. http://www.uwstout.edu/lib/thesis/2005/2005pedersenk.pdf.

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2

Morris, Melinda. "Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study." University of Western Australia. School of Surgery and Pathology, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0012.

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[Truncated abstract] Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy: a population-based study. Aim: Using a population-based cohort of colorectal cancer (CRC), the major aims of this study were to: 1. Identify clinico-pathological markers that can be used to define a subset of stage II colon cancer patients with excellent prognosis and who therefore do not require referral for adjuvant chemotherapy; 2. Investigate whether there is a survival benefit from the use of adjuvant chemotherapy in a population-based cohort of stage II colon cancer; 3. Investigate stage III colon cancer patients for evidence of predictive markers for response to 5FU chemotherapy; 4. Investigate CRC for age-related differences in clinico-pathological and molecular features. Hypotheses to be tested: 1. A subset of good prognosis stage II colon cancers can be defined using routine pathological markers; 2. Females colon cancer patients gain more survival advantage from 5FU chemotherapy than males; 3. Tumours from young CRC patients have different molecular characteristics to those from older patients; 4. The underlying molecular characteristics of tumour can impact upon the response to 5FU chemotherapy. Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: The major findings of this translational research into colon cancer can be summarized as follows: The morphological features of serosal and vascular invasion allow for prognostic stratification of stage II colon cancer into
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3

Hou, Wai-kai. "Psychosocial resources and adaptation among Chinese people with colorectal cancer." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634346.

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4

Wong, Kwun-ping Flora. "A study of MSH2 founder mutation in Hong Kong population." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41712316.

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5

Chan, Tsun-leung. "Genomic instability and DNA mismatch repair gene mutations in colorectal cancer /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21028874.

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6

Keller, Elizabeth Greer. "Novel chemotherapeutics against lung and colon cancer." Click here for download, 2010. http://proquest.umi.com.ps2.villanova.edu/pqdweb?did=1961333981&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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7

Purnell, Jason Q. "Testing a socio-cultural model of colorectal cancer screening among African Americans." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1178232378.

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8

Wong, Cesar Sze Chuen. "The expression and clinical applications of Wnt-signaling molecules in breast and colorectal cancers /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202002%20Wong.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002.
Includes bibliographical references (leaves 170-194). Also available in electronic version. Access restricted to campus users.
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9

黃冠萍 and Kwun-ping Flora Wong. "A study of MSH2 founder mutation in Hong Kong population." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41712316.

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10

Vase, Hollie Francesca. "Interrogating therapeutic manipulation of the endocannabinoid system in the human colon." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798.

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The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in pathophysiological conditions, including colon inflammation and cancer. However, the contribution of the ECS within each of these conditions has not been fully elucidated. This indicates that the current identification of key targets within the ECS that are involved in gut pathology could be used as potential novel therapeutics. Two experimental approaches were designed and optimised to give an insight into ECS signal regulation within the human colon and to screen ECS therapeutics, tetrahydrocannabinol (THC) and cannabidiol (CBD); a human colon ex vivo explant culture model and an innovative multiplexed quantitative gene expression technology, the GenomeLab GeXP system (Beckman Coulter). Gene targets were identified that are known markers of regulation and function in cells of healthy tissue. An assay, the hCellMarkerPlex was designed that incorporated twenty-three of these gene targets, epithelial (EZR, KRT18, SLC9A2), proliferation (PCNA, CCND1, MS4A12), differentiation (B4GANLT2, CDX1, CDX2), apoptotic (CASP3, NOX1, NTN1), fibroblast (FSP1, COL1A1), structural (ACTG2, CNN1, DES), gene transcription (HDAC1), stem cell (LGR5), endothelial (VWF) and mucin production (MUC2). The hCellMarkerPlex identified gene signatures which distinguished between normal, adenoma and carcinoma tissue, identifying cellular processes showing abnormal activity associated with pathological status. The resulting biomarker profiles were used to establish a human colon explant culture system. The human colon explant culture presents a novel model to study modulation of the ECS and screen ECS therapeutics. Combined with the GenomeLab GeXP System multiple components of the ECS were assessed at the gene regulatory level. A custom designed GeXP assay, the hECSplex, was developed. hECSplex gene expression signatures of EC receptors (CNR1, CNR2, GPR55 and TRPV1), ECS enzymes (NAPE-PLD, GDE1, DAGLA, DAGLB, FAAH, FAAH2 and PTGS2), inflammatory (IL1B, IL10, IL6, LEP, TNF and SOCS3), signalling pathway (ID1, BCL2, CFL1, BIRC5, TP53, MYC and KRAS), lipid production (SREBF1, ACACA), and plasma-membrane (OCLN) markers revealed altered expression of ECS components in carcinogenesis compared to normal tissue. Abstract vi . The hECSplex gene expression signature of colon explants showed that ECS was not altered during culture, emphasising the explant models capability as a pharmaceutical tool to test current and novel therapeutics. Applications of both THC and CBD to normal colon explants at different concentrations do not lead to any significant changes. Indicating the current pharmacological use of phytocannabinoids is causing no adverse effects in surrounding healthy colon tissue. The GenomeLab System presents new opportunities to interrogate multiple components of the endocannabinoid signalling system in small colon explant tissue samples, and in response to ECS therapeutics.
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11

冼嘉敏. "羽扇豆醇抑制結腸癌細胞生長初步機理研究." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1324.

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12

Johanknecht, Viva M. "The effect of the antioxidant, Coenzyme Q, on Coco-2 colon cells treated with iron to reduce lipid peroxidation." Online version, 2002. http://www.uwstout.edu/lib/thesis/2002/2002johanknechtv.pdf.

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13

Pasala, Paulitha. "Effect of streptozocin-induced hyperglycemia on 5-hydroxytryptamine (5-HT)-evoked motility and secretory responses in colon." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1328119.

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Previous studies have focused on gastric dysmotility and delayed emptying in diabetes mellitus. There is little information about the effects of hyperglycemia on colonic motility and secretion. 5-HT was reported to mediate contractile activity by activating receptors on both enteric neurons and smooth muscle cells. The aim of this study was to investigate and compare the effects of 5-HT on circular contractile activity coordinated with secretion in streptozocin-induced diabetic and non-diabetic rats. Sonomicrometry and voltage clamping techniques were used to measure motility and secretion simultaneously in isolated whole thickness colonic sheets. Male Sprague Dawley rats were injected with streptozocin (65 mg/kg body weight) in 0.1 M sodium citrate buffer, into the tail veins. Glucose levels of 300-400 mg/dl and above were achieved. The control rats were injected with the same volumes of vehicle (0.1 M sodium citrate buffer). Animals were sacrificed 10-12 days following the induction of hyperglycemia. Flat sheets of colon were mounted serosal side up in Ussing chambers. 1 mm piezocrystals were glued to the serosal surface 4-5 mm apart to measure circular contractions as decrease in inter-crystal distances (ICD). Voltage-clamping the tissues at 0 mV was used ix to measure short circuit current (Isc), indicative of chloride secretion. In diabetic rats 50 gM 5-HT caused mean amplitude of contractions of 174 ± 26 gm (n=4), which was significantly reduced as compared to the response in non-diabetic rats of 970 + 243 gm (n=4; p<0.05). The secretory response in diabetic rats paralleled the reduction in ICD (diabetic: 23 +1 gA/cm2, controls: 57 + 18 gA/cm2). Neural blockade with 0.1 gM TTX revealed a decreased myogenic contractile activity in diabetic rats. The mean amplitude of contractions after TTX in diabetic rats was 162 ± 45 gm verses controls of 612 ± 86 gm. These results suggest that the reduction of the 5-HT contractile response in diabetic rats may be a composite of direct effects on the smooth muscle as well as indirect effects on the neurons.
Department of Physiology and Health Science
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14

Piccariello, Thomas. "Studies relating to fecapentaene-12." Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54399.

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The glyceryl enol ether fecapentaene-12 (FP-12) is a direct-acting mutagen that is formed by bacteria in the lower part of the gastrointestinal tract from a precursor of unknown structure. Two major unsolved questions concerning FP-12 are the structure of its precursor and the nature of its interaction (if any) with DNA. The structure of the biosynthetic precursor of FP-12 is thought to be that of a plasmalogen with an intact pentaenyl ether moiety. A synthesis of the perhydro analog of the proposed precursor structure is described, and approaches to the synthesis of the precursor itself are also described. Comparison of chromatographic data for the saturated model precursor and natural precursor provided evidence for the structure of the latter. The nature of the interactions of FP-12 with DNA was probed by model studies of the reaction of nucleoside bases with FP-12 and two proposed FP-12 metabolites. No adducts were formed between FP-12 or between the various putative polyenal metabolites and guanosine, cytosine, or thymidine. A model epoxy ether did react with a guanosine derivative, however, indicating that an epoxy ether derivative of FP-12, if formed, would be capable of reacting with DNA.
Ph. D.
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15

Moura, Nelci Antunes de [UNESP]. "Efeitos da ingestão de Yacon (Smallanthus sonchifolius) sobre o processo de carcinogênese de cólon induzido pela 1, 2-dimetilhidrazina em ratos wistar." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/87766.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Yacon (Smallanthus sonchifolius) é uma raiz originária da região dos Andes que tem se destacado pelos seus compostos bioativos principalmente frutanos como futooligossacarídeos e inulina. O presente projeto teve como objetivo determinar a atividade quimioprotetora da ingestão de Yacon sobre o desenvolvimento de lesões pré-neoplásicas (focos de criptas aberrantes-FCA) induzidas pela dimetilhidrazina (DMH) em ratos Wistar machos. Os animais foram divididos em seis grupos com 5 a 12 animais cada. Os animais dos Grupos 1 a 4 e Grupos 5 e 6 receberam respectivamente, quatro injeções subcutâneas de DMH (40 mg/Kg) e solução de EDTA (veículo da DMH) nas duas semanas iniciais do experimento respectivamente. Os animais receberam ração basal até a sexta semana do experimento e a partir desta os animais dos grupos 2, 3, 4, 5 receberam ração acrescida de extrato de Yacon a 0,5%, 1%, 1% e 1%, respectivamente. Os animais do grupo 4 receberam Lactobacilus casei (2,5 x 1010 de UFC por Kg de ração). O sacrifício ocorreu na vigésima semana de experimento para análise de focos de criptas aberrantes (FCA) e tumores. Nossos resultados mostraram uma redução no número, multiplicidade de FCA e no número de adenocarcinomas invasivos nos grupos tratados com 1% yacon (G3) e na combinação simbiótica (G4), (0,05 < p < 0, 001). A multiplicidade de tumores (invasivos e não invasivos) foi significativamente menor no grupo tratado com a combinação simbiótica (p < 0,02). Observou-se também uma redução significativa nas taxas de proliferação celular tanto em criptas colônicas como em tumores nos grupos tratados com 1% yacon (G3) e na combinação simbiótica (G4), p < 0.001. Os resultados sugerem que a ingestão de extrato de yacon exerce atividade quimiopreventiva contra carcinogênese de cólon
Yacon (Smallanthus sonchifolius) is a tuberous root native to the Andean region of South America which contains high amounts of inulin-type fructans. The present study investigated the beneficial potential of yacon root intake on development of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. Six groups were studied: Groups 1–4 were given four s.c. injections of DMH (40 mg/kg b.w.) twice a week, during two weeks, whereas Groups 4 and 5 received similar injections of EDTA solution (DMH vehicle). After 6 weeks of DMH-initiation, groups were fed with basal diet (G1 and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon root plus Lactobacillus casei at 2.5 x 1010 CFU per g diet) for 13 weeks. At 20 week, all animals were killed and the colons were analyzed for development of aberrant crypt foci (ACF) and tumor. A significant reduction in number and multiplicity of ACF and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon root (G3) or their synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower solely in group fed with symbiotic formulation (p < 0.02). Also, a reduction in cell proliferation indexes in colonic crypt and tumor were observed in groups orally treated with 1.0% yacon root (G3) or their synbiotic formulation (G4) (p < 0.001). The findings this study suggest that yacon root intake may have potential as chemopreventive agent against colon carcinogenesis
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16

Gorgulho, Carolina Mendonça [UNESP]. "Terapia gênica com interferon-alfa no controle do câncer colorretal." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132114.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O interferon alfa (IFN-α), um IFN do tipo I, se apresenta como uma citocina com grande potencial terapêutico, pois atua no combate direto às células tumorais, além de agir sobre a maturação de células dendríticas (DCs), que são células apresentadoras de antígenos profissionais e peças chave na elaboração da uma resposta antitumoral. Entretanto, a administração sistêmica de citocinas pode produzir toxicidade importante nos pacientes, de modo que a indução de sua produção in situ poderia representar uma forma de imunomodulação mais adequada. Assim, o objetivo deste estudo é verificar a ação de vetores lentivirais carregando o gene do IFN-α para transdução de células tumorais, permitindo assim a produção localizada de IFN-α, a fim de explorar, in vitro, seu potencial lítico e imunomodulatório sobre DCs. Vetores lentivirais carregando o gene do IFN-α humano (Lego-IFN) ou GFP (Lego-GFP) foram utilizados para a transdução in vitro de células de câncer colorretal. A transdução foi feita com diferentes multiplicidades de infecção (MOIs - 0.3, 1.0, 2.0, 4.0) para avaliarmos o efeito dose-dependente, seguido de co-cultura com DCs derivadas de monócitos de doadores saudáveis (DC-0.3, DC-1.0, DC-2.0, DC-4.0). Após 48h de co-cultura, as DCs foram avaliadas fenotípica e funcionalmente, através da análise dos marcadores de membrana por citometria de fluxo, capacidade de aloestimulação e de indução de linfócitos T citotóxicos (CTLs). Nós observamos que a transdução com Lego-GFP, mas não com Lego-IFN, aumentou a imunogenicidade das células tumorais, com aumento de expressão de CD54 e HLA-DR. A co-cultura de DCs com células tumorais transduzidas com Lego-IFN aumentou discretamente seu perfil de ativação, mas não seu potencial aloestimulatório in vitro. Observamos que linfócitos cultivados com DC-2.0 produziram níveis mais altos de IFN-γ, sugerindo a indução de um perfil Th1, enquanto que...
Interferon alpha (IFN-α) is a type I IFN with great therapeutic potential, since it is able to directly fight tumor cells and enhance the maturation of dendritic cells (DCs), the main antigen-presenting cells, required for an effective antitumor response. However, the systemic administration of cytokines can induce severe collateral effects. Therefore, the induction of cytokine secretion in situ should represent a more adequate approach for cytokine-based immunotherapy. Thus, the goal of this study was to induce IFN-α secretion by colon cancer cells by transduction with a lentivirus vector carrying the human IFN-α gene, followed by analysis of its immunomodulatory potential over DCs. Transduction was made with different multiplicities of infection (MOIs - 0.3, 1.0, 2.0 and 4.0) to evaluate the dose-dependent effects. Such cells were co-cultured with monocyte-derived DCs from healthy donors (DC-0.3, DC-1.0, DC-2.0 and DC-4.0). Forty-eight hours later, DCs were evaluated for their phenotype (surface activation/maturation markers) by flow cytometry, their ability to induce allogeneic response in a mixed leukocyte reaction (MLR) and effectiveness to induce cytotoxic T cells. We observed that transduction with Lego-GFP, but not Lego-IFN, increased tumor cells' immunogenicity with up-regulation of the markers CD54 and HLA-DR. Co-culture of Lego-IFN-transduced tumor cells with DCs slightly enhanced their activation phenotype but not their potential to stimulate T cell proliferation in vitro. Furthermore, we observed that lymphocytes cultured with DC-2.0 produced higher levels of IFN-γ, suggesting an induction of Th1 profile on T cells, while DC-GFP induced more IL-10 and IL-4. Additionally, DC-4.0 was more efficient in generating cytotoxic T lymphocytes (CTLs) that the control DC, however DC-GFP induced even more CD8+T cell proliferation. The enhancement of tumor cell immunogenicity and the superior induction of CLTs ...
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17

Moura, Nelci Antunes de. "Efeitos da ingestão de Yacon (Smallanthus sonchifolius) sobre o processo de carcinogênese de cólon induzido pela 1, 2-dimetilhidrazina em ratos wistar /." Botucatu, 2012. http://hdl.handle.net/11449/87766.

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Orientador: Luís Fernando Barbisan
Banca: Luís Antônio Justulim Júnior
Banca: Carlos Eduardo Andrade Chagas
Resumo: Yacon (Smallanthus sonchifolius) é uma raiz originária da região dos Andes que tem se destacado pelos seus compostos bioativos principalmente frutanos como futooligossacarídeos e inulina. O presente projeto teve como objetivo determinar a atividade quimioprotetora da ingestão de Yacon sobre o desenvolvimento de lesões pré-neoplásicas (focos de criptas aberrantes-FCA) induzidas pela dimetilhidrazina (DMH) em ratos Wistar machos. Os animais foram divididos em seis grupos com 5 a 12 animais cada. Os animais dos Grupos 1 a 4 e Grupos 5 e 6 receberam respectivamente, quatro injeções subcutâneas de DMH (40 mg/Kg) e solução de EDTA (veículo da DMH) nas duas semanas iniciais do experimento respectivamente. Os animais receberam ração basal até a sexta semana do experimento e a partir desta os animais dos grupos 2, 3, 4, 5 receberam ração acrescida de extrato de Yacon a 0,5%, 1%, 1% e 1%, respectivamente. Os animais do grupo 4 receberam Lactobacilus casei (2,5 x 1010 de UFC por Kg de ração). O sacrifício ocorreu na vigésima semana de experimento para análise de focos de criptas aberrantes (FCA) e tumores. Nossos resultados mostraram uma redução no número, multiplicidade de FCA e no número de adenocarcinomas invasivos nos grupos tratados com 1% yacon (G3) e na combinação simbiótica (G4), (0,05 < p < 0, 001). A multiplicidade de tumores (invasivos e não invasivos) foi significativamente menor no grupo tratado com a combinação simbiótica (p < 0,02). Observou-se também uma redução significativa nas taxas de proliferação celular tanto em criptas colônicas como em tumores nos grupos tratados com 1% yacon (G3) e na combinação simbiótica (G4), p < 0.001. Os resultados sugerem que a ingestão de extrato de yacon exerce atividade quimiopreventiva contra carcinogênese de cólon
Abstract: Yacon (Smallanthus sonchifolius) is a tuberous root native to the Andean region of South America which contains high amounts of inulin-type fructans. The present study investigated the beneficial potential of yacon root intake on development of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. Six groups were studied: Groups 1-4 were given four s.c. injections of DMH (40 mg/kg b.w.) twice a week, during two weeks, whereas Groups 4 and 5 received similar injections of EDTA solution (DMH vehicle). After 6 weeks of DMH-initiation, groups were fed with basal diet (G1 and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon root plus Lactobacillus casei at 2.5 x 1010 CFU per g diet) for 13 weeks. At 20 week, all animals were killed and the colons were analyzed for development of aberrant crypt foci (ACF) and tumor. A significant reduction in number and multiplicity of ACF and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon root (G3) or their synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower solely in group fed with symbiotic formulation (p < 0.02). Also, a reduction in cell proliferation indexes in colonic crypt and tumor were observed in groups orally treated with 1.0% yacon root (G3) or their synbiotic formulation (G4) (p < 0.001). The findings this study suggest that yacon root intake may have potential as chemopreventive agent against colon carcinogenesis
Mestre
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18

Bryan, Jeffrey N. "Copper-64-labelled antibodies for the radioimmunotherapy of colon cancer in a mouse model /." Free to MU Campus, others may purchase, 2005. http://wwwlib.umi.com/cr/mo/fullcit?p1426051.

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19

Lai, Man Po. "Single nucleotide polymorphisms of CYP2C19 gene and AHR gene and their associations to colorectal cancer and breast cancer risk in Han Chinese population /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202007%20LAI.

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20

Lynn, Penelope Ann. "An electrophysiological investigation of colonic afferent sensitivity in the rat and mouse - in vitro /." Title page, contents and general abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phl989.pdf.

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21

Tsai, Kai-yuen. "Clinical guideline in maintaining normothermia in colorectal patients." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40721358.

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22

Liu, Siu-kwong. "Analytical review of reasons for delay in help-seeking for colorectal cancer related symptoms." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42997343.

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Chan, On-on Annie. "Methylation in colorectal cancer." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25256312.

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Lau, Yue-huen Thomas. "Ultrastructural and stereological investigation of the effects of hexamethylene bisacetamide on human colon carcinoma LoVo cells in vitro /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22079105.

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Li, Haitao. "Resveratrol derivatives as colorectal cancer chemopreventive agents." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43703720.

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Morais, Marina. "Morphometric and AgNOR studies of normal, transitional and malignant human colorectal epithelium." Thesis, [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13692707.

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Johnson, Jodee Lee. "Effect of back raspberry extracts on colon cancer cell proliferation." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1244025041.

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Fragoso, Mariana Franco [UNESP]. "Efeito protetor do açaí (Euterpeoleracea Martius) na promoção da carcinogênese de cólon em ratos Wistar." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/95895.

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Açaí, fruto da Euterpe oleraceae Martius, é consumido in natura e em uma variedade de bebidas e alimentos. Esse fruto tem sido bastante consumido e produzido no Brazil, devido à alta popularidade como alimento funcional com capacidade antioxidante e antiinflamatória. Este trabalho investigou o efeito protetor potencial do consumo da polpa de açaí (PA) seca por pulverização na carcinogênese de cólon induzida pela 1,2-dimetilhidrazina (DMH) em ratos Wistar adultos (peso médio de 200g). Após 4 semanas de administração de DMH, os grupos passaram a receber dieta padrão, dieta contendo 2.5% ou 5.0% de PA e 0.2% de N-acetilcisteína (NAC) durante 10 semanas de tratamento para análise de focos de criptas aberrantes (FCA). Adicionalmente, dois grupos receberam dieta padrão e dieta contendo 5.0% de PA durante 20 semanas de tratamento para análise de tumores de cólon. No experimento de 14 semanas, foi observada redução significante no número de criptas aberrantes (CA) e em FCA (1-3 CA) nos grupos que receberam 5.0% de PA e 0.2% de NAC (37% e 47% de inibição, p = 0.036; 37% e 41% de inibição, p = 0.042), respectivamente, quando comparados ao grupo não tratado. No experimento de 24 semanas, foi observada redução no número de adenocarcinomas invasivos e multiplicidade de tumores no grupo que recebeu 5.0% de PA na dieta (p < 0.005 e p = 0.001, respectivamente) quando comparados ao grupo não tratado. Além disso, redução significante na proliferação celular de tumores marcados com Ki-67 e na taxa de crescimento tumoral foi observada no grupo que recebeu 5.0% de PA (p = 0.003 e p = 0.001). Portanto, os resultados desse trabalho indicam que uma dieta acrescida de 5.0% da polpa de açaí seca por pulverização pode reduzir o desenvolvimento de FCA e de tumores de colón induzidos em ratos, indicando seu uso como um potencial alimento funcional
Acai, fruit from Euterpe oleraceae Martius, is consumed in natura and in a variety of beverages and food preparations. This fruit has been widely consumed and produced in Brazil, due to the high popularity as a functional food with antioxidant and anti-inflammatory capacities. This study investigated the potential protective effect of spray-dried açai pulp (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male adult Wistar rats (mean weight of 200g). After 4 weeks of DMH administration, groups were fed standard diet, diet containing AP at 2.5% or 5.0% or 0.2% N-acetylcysteine (NAC) during 10 weeks for analysis of aberrant crypt foci (ACF) as endpoint. Additionally, two groups were fed standard diet or diet containing AP at 5.0% during 20 weeks for analysis of colon tumor as endpoint. In 14-week ACF assay, a significant reduction in number of aberrant crypt (AC) and in ACF (1-3 AC) were observed in groups fed 5.0% AP and 0.2% NAC (37% and 47% inhibition, p = 0.036; 37% and 41% inhibition, p = 0.042), respectively, when compared to the untreated group. In 24-week tumor assay, a significant reduction in number of invasive adenocarcinomas and tumor multiplicity were observed in group fed 5.0% AP (p < 0.005 and p = 0.001, respectively) when compared to untreated group. Also, significant reduction in tumor Ki-67 cell proliferation and growth index was observed in group fed 5.0% AP (p = 0.003 and p = 0.001). Therefore, the findings of this study indicate that spray-dried açai pulp feeding at 5.0% may reduce the development of chemically-induced ACF and colon tumor in male rats, indicating their use as a potential functional food
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29

Fragoso, Mariana Franco. "Efeito protetor do açaí (Euterpeoleracea Martius) na promoção da carcinogênese de cólon em ratos Wistar /." Botucatu, 2013. http://hdl.handle.net/11449/95895.

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Orientador: Luis Fernando Barbisan
Banca: Camila Renata Correa
Banca: Sérgio Britto Garcia
Resumo: Açaí, fruto da Euterpe oleraceae Martius, é consumido in natura e em uma variedade de bebidas e alimentos. Esse fruto tem sido bastante consumido e produzido no Brazil, devido à alta popularidade como alimento funcional com capacidade antioxidante e antiinflamatória. Este trabalho investigou o efeito protetor potencial do consumo da polpa de açaí (PA) seca por pulverização na carcinogênese de cólon induzida pela 1,2-dimetilhidrazina (DMH) em ratos Wistar adultos (peso médio de 200g). Após 4 semanas de administração de DMH, os grupos passaram a receber dieta padrão, dieta contendo 2.5% ou 5.0% de PA e 0.2% de N-acetilcisteína (NAC) durante 10 semanas de tratamento para análise de focos de criptas aberrantes (FCA). Adicionalmente, dois grupos receberam dieta padrão e dieta contendo 5.0% de PA durante 20 semanas de tratamento para análise de tumores de cólon. No experimento de 14 semanas, foi observada redução significante no número de criptas aberrantes (CA) e em FCA (1-3 CA) nos grupos que receberam 5.0% de PA e 0.2% de NAC (37% e 47% de inibição, p = 0.036; 37% e 41% de inibição, p = 0.042), respectivamente, quando comparados ao grupo não tratado. No experimento de 24 semanas, foi observada redução no número de adenocarcinomas invasivos e multiplicidade de tumores no grupo que recebeu 5.0% de PA na dieta (p < 0.005 e p = 0.001, respectivamente) quando comparados ao grupo não tratado. Além disso, redução significante na proliferação celular de tumores marcados com Ki-67 e na taxa de crescimento tumoral foi observada no grupo que recebeu 5.0% de PA (p = 0.003 e p = 0.001). Portanto, os resultados desse trabalho indicam que uma dieta acrescida de 5.0% da polpa de açaí seca por pulverização pode reduzir o desenvolvimento de FCA e de tumores de colón induzidos em ratos, indicando seu uso como um potencial alimento funcional
Abstract: Acai, fruit from Euterpe oleraceae Martius, is consumed in natura and in a variety of beverages and food preparations. This fruit has been widely consumed and produced in Brazil, due to the high popularity as a functional food with antioxidant and anti-inflammatory capacities. This study investigated the potential protective effect of spray-dried açai pulp (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male adult Wistar rats (mean weight of 200g). After 4 weeks of DMH administration, groups were fed standard diet, diet containing AP at 2.5% or 5.0% or 0.2% N-acetylcysteine (NAC) during 10 weeks for analysis of aberrant crypt foci (ACF) as endpoint. Additionally, two groups were fed standard diet or diet containing AP at 5.0% during 20 weeks for analysis of colon tumor as endpoint. In 14-week ACF assay, a significant reduction in number of aberrant crypt (AC) and in ACF (1-3 AC) were observed in groups fed 5.0% AP and 0.2% NAC (37% and 47% inhibition, p = 0.036; 37% and 41% inhibition, p = 0.042), respectively, when compared to the untreated group. In 24-week tumor assay, a significant reduction in number of invasive adenocarcinomas and tumor multiplicity were observed in group fed 5.0% AP (p < 0.005 and p = 0.001, respectively) when compared to untreated group. Also, significant reduction in tumor Ki-67 cell proliferation and growth index was observed in group fed 5.0% AP (p = 0.003 and p = 0.001). Therefore, the findings of this study indicate that spray-dried açai pulp feeding at 5.0% may reduce the development of chemically-induced ACF and colon tumor in male rats, indicating their use as a potential functional food
Mestre
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30

Butler, Lisa Maree. "Molecular analysis of the human Fas gene in colorectal cancer /." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phb9858.pdf.

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31

Cheung, Him-chun Horace, and 張謙俊. "The impact of POSSUM score on long-term outcome of patients with colorectal cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45160752.

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Tipoe, George Lim. "A histological and ultrastructural morphometric assessment of malignant potential in human colorectal epithelium." Thesis, [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13641347.

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33

Fang, Lanyan. "An integrated system for tumor detection and target drug therapy of colorectal cancers with a humanized tumor targeting antibody, HuCC49[delta]CH2." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1173905544.

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34

Le, Leu Richard Kevin. "The effect of a diminished folate status on colorectal carcinogenesis /." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phl539.pdf.

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35

Wong, Pui-shan Helen. "Study of the role of [beta]-adrenoceptors in the promotion of colon cancer growth." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39570885.

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36

蔡啟源 and Kai-yuen Tsai. "Clinical guideline in maintaining normothermia in colorectal patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40721358.

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37

鄭曉朦. "治療結腸癌的中藥考證." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/236.

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研究目的：結腸癌是現今最常見的惡性腫瘤之一。在西方國家， 其發病率甚至居惡性腫瘤的第二位，在我國發病率居第四位，並且發病率在不斷攀升。在長江中下游，江淅地區，福建，香港等較為發達地區發病率較高，研究提示可能與經濟發達、生活習慣以及飲食習慣有密切關係。隨著醫療技術的進步，西醫針對結腸癌已有多種治療手段。其中，于術治療、放化療綜合治療是主要的治療手段。但在一定程度上對患者機體有一定的毒副作用，嚴重影響生活品質，並且復發和轉移率較高。研究者發現一些中藥對結腸癌細胞有抑制細胞生長、影響腫瘤細胞相關資訊表達、抑制腫瘤細胞血管生成、誘導腫瘤細胞凋亡、對信號轉導通路的影響等作用。中草藥毒副作用小，成本低廉，提高患者生活品質，降低復發和轉移率。因此，中藥對結腸癌的抑制作用有較高的研究價值。 研究方法：選取人結腸癌HCTl 16 細胞用McCoys 5A 的細胞培養液放置於37 ℃、C02 體積分數為5%的培養箱中靜置培養。研究藥物選擇首先對結腸癌進行中醫辨證，分析每種證型用藥特點。其次在中國期刊全文資料庫進行關於結腸癌文獻檢索，在檢索結果中找出辨證分析中藥物出現頻率較高的。最後，查找相關碩士、博士論文以及有關結腸癌書籍資料篩選出以下幾種進行考證對結腸癌細胞是否有抑制作用的中草藥。（土茯苓、白花蛇古草、馬齒莧、藤梨根、敗醬草、白頭翁） 。分別用DCM 以及MEOH 提取土茯苓、白花蛇古草、馬齒莧、藤梨根、敗醬草、白頭翁，將培養好的細胞種植在96 孔板上，分別加入上述藥物提取物。用SRB 法檢測細胞的增殖情況。 研究結果： 根據實驗所得數據發現， 其中茯夜苓、和敗醬草的DCM 提取液均對HCT116細胞有較強的抑制作用，白花蛇古草對此種結腸癌細胞雖有抑制細胞增殖的作用，但結果並不明顯，實驗所得結果還有待反復實驗，以及進一步探究作用機制。然而藤梨根、馬齒莧、白頭翁的DCM 提取液以及用MEOH 提取的上述藥物均對細胞HCT116 無明顯抑制作用， 考慮實驗僅對單一細胞進行，檢測藥物提取物作用於HCT116 細胞的抑制性 。因此， 本實驗僅為六種中草藥提純物對HCT l 16 細胞的抑制作用初步探究，還有待進一步深入研究。
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38

Nazymok, Y. V. "Variant anatomy of the sigmoid colon and sigmoidorectal segment in the third trimester fetuses." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18452.

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Zhang, Zichen. "Anticancer effects of hexamethylene bisacetamide on human colon carcinoma cells in vitro /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21021065.

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40

Robinson, Clayt Austin. "Development of an in vitro three-dimensional model for colon cancer study and drug efficacy analysis." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124223577.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xvi, 204 p.; also includes graphics (some col.). Includes bibliographical references (p. 196-204). Available online via OhioLINK's ETD Center
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41

Fredericks, Ernst. "Molecular signaling in colorectal carcinogenesis : the roles and relationships of beta-catenin, PPARgamma and COX-2." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1021014.

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Colorectal cancer (CRC) is a common disease with significant morbidity and mortality. In spite of significant advances in understanding the molecular signaling in this disorder, unanswered questions remain. Cyclooxygenase-2 (COX-2) and β-catenin have established roles in colorectal carcinogenesis, with both being upregulated early in the disease course. The role of peroxisome proliferator-activated receptor γ (PPARγ) is less clear, but has been shown to be downregulated in colon cancer models. Butyrate, a short chain fatty acid, produced by colon microbiota and transported into the colonocyte by transporter proteins, appears to be important in early carcinogenesis. The butyrate concentration is reduced in CRC and so are its transporters. Interleukin-17 (IL-17) plays a role in colitis-associated colorectal cancer (CAC), but its function in sporadic CRC is less clear. Similarly, Protein kinase C (PKC) has proven involvement in many solid tumours, including CRC, but its exact mechanistic role is still speculative. AIM: To investigate the role and possible signaling pathways of the major role players, β-catenin, COX-2 and PPARγ in early CRC. Further, to elucidate the mechanistic pathways of butyrate and its transporters, IL-17 and PKC in CRC. METHOD: Informed consent was obtained for all patients. Patients were recruited in various disease categories, including normal, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and CRC. Colon biopsy specimens were obtained during colonoscopy and used for immunohistochemistry (IHC) and gene expression analysis of the above genes by quantitative polymerase chain reaction (qPCR). RESULTS: β-catenin mRNA and protein expression was increased in CRC and the IBD groups compared to the normal group, while it was reduced in the IBS groups. COX-2 mRNA expression showed a steady increase from normal, through IBS, IBD and CRC groups to a statistically significant degree. The COX-2 protein expression, however, did not match the mRNA expression with increased COX-2 protein expression in normal and IBS groups and reduced expression in IBD and CRC groups. PPARγ mRNA expression was unchanged in IBD and CRC groups, but significantly increased in the IBS group compared to normal. Butyrate transporter, SLC16A1 mRNA was significantly reduced in CRC, but also in the IBS groups, which was unexpected. In the IBD group, SLC16A1 mRNA was unchanged in Crohn’s disease (CD) but significantly reduced in ulcerative colitis (UC). Similarly, SLC5A8 mRNA expression was significantly reduced in the CRC as well as the IBS groups. In the IBD groups, SLC5A8 was unchanged in UC but significantly increased in CD. IL-17 mRNA expression was significantly reduced in CRC and IBS groups, but unchanged in the IBD groups. PKCε mRNA was significantly increased in CRC as expected. In the IBD groups, PKCε mRNA was unchanged in CD but significantly increased in UC. In the IBS groups, PKCε mRNA in constipation –IBS (C-IBS) was significantly reduced, but unchanged in diarrhoea – IBS (D-IBS). CONCLUSIONS: β-catenin mRNA and protein expression was increased in CRC and the CRC promoting IBD groups. COX-2 protein expression was incongruent with the COX-2 mRNA expression and this may reflect homeostatic control mechanisms. High COX-2 mRNA expression in CRC and CRC promoting IBD groups may be a secondary phenomenon reflecting the inflammatory milieu, rather than a true carcinogenesis-related event. PPARγ does not appear to play a central role in early colon carcinogenesis, in spite of available literature suggesting otherwise. Butyrate transporters showed inconsistent results and for now no firm conclusions can be drawn from this. IL-17 may play a role in CAC as confirmed in this and other studies, but its role in sporadic CRC is tenuous and requires further investigation. Likewise for PKCε, upregulation is associated with increased tumourigenecity as shown in this study, however, the mechanistic pathway(s) involved is still speculative and requires further study.
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Liu, Siu-kwong, and 劉兆廣. "Analytical review of reasons for delay in help-seeking for colorectal cancer related symptoms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42997343.

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43

Liu, Qing, and 刘晴. "Effect of Tian Xian Liquid on growth inhibition in colon cancer and moderation of 5-fluorouracil-induced myelosuppression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45587188.

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44

Lopes, Gisele Aparecida Dionísio [UNESP]. "Repercusões a longo prazo do padrão alimentar ocidental ocorrido durante a gestação, lactação e fase juvenil na susceptibilidade ao desenvolvimento de câncer do cólon em ratos." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/115943.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Investigamos as repercussões do padrão alimentar ocidental, rico em gordura, (óleo de milho) (20%) e pobre em micronutrientes [ácido fólico (1 mg/g), colina (0,12%) e fibra (2%)], ocorrido durante a gestação, lactação e puberdade na susceptibilidade ao desenvolvimento de câncer do cólon induzido pela 1,2-dimetilhidrazina (DMH) no rato. Avaliamos se a reintrodução da dieta Ocidental durante a vida adulta em animais previamente expostos à dieta Ocidental durante a vida intrauterina, lactação e puberdade, pode modificar a susceptibilidade à oncogênese do cólon pela DMH. Ratas fêmeas SD prenhes receberam dieta semi-purificada controle (AIN-93) ou do tipo Ocidental (WD - Western Style Diet) a partir do dia gestacional 12 (DG 12). Após o desmame (dia 21), a prole de machos permaneceu com o mesmo tipo de dieta de suas mães até o dia pós-natal 50 (DPN 50). Nesse momento, receberam quatro injeções subcutâneas de DMH (40mg/kg) e foram divididos nos seguintes grupos/dietas: Grupo I (AIN-93/DMH/AIN-93) recebeu dieta controle durante todo o experimento (DG 12- DPN 370), o Grupo II (AIN-93/DMH/Ocidental) recebeu dieta Ocidental somente na vida adulta, a partir do DPN 260, Grupo III (Ocidental/DMH/AIN-93) recebeu dieta Ocidental desde a vida intrauterina até o início da puberdade (DG 12 - DPN 50), e o Grupo IV (Ocidental/DMH/Ocidental) recebeu dieta Ocidental desde a vida intrauterina até o início da puberdade (DG 12 - DPN 50), e foi reintroduzido à dieta Ocidental na vida adulta (DPN 260). Todos os animais foram eutanasiados ao final da 50ª semana de experimento (DPN 370). O cólon foi removido e submetido à análise estereoscópica e histológica para determinar o número, distribuição e multiplicidade dos focos de criptas aberrantes (FCAs). As características das lesões neoplásicas e os níveis séricos de insulina e leptina foram analisados à necropsia. A exposição à dieta Ocidental durante a gestação, ...
We examined the effects of a Western Style Diet (WD), high in fat (corn oil) (20%) and low in micronutrients [i.e.; folic acid (1 mg/g), choline (0.12%) and fiber (2%)] during pregnancy, lactation and in prepubertal stage to examine the susceptibility to colon carcinogenesis induced by dimethylhydrazine (DMH) in male Sprague-Dawley (SD) rats as later adults. We also evaluated whether WD reintroduction during adulthood can modify susceptibility to colon carcinogenesis. Pregnant SD rats received one of two diets AIN-93G or WD at gestational day 12 (GD 12). F1 male pups were weaned (21d) and fed the same AIN- 93G or WD diets from their dams until postnatal day 50 (PND 50). At this point, they were given four subcutaneous injections of carcinogen DMH (40 mg/body weight) and were shared the following diets/group: group I (AIN-93/DMH/AIN-93) a lifetime control diet-fed group (GD 12 until postnatal day - PND 370), group II (AIN-93/DMH/WD) received WD only in adulthood (at PND 260), group III (WD/DMH/AIN-93) received WD during pregnancy from dams until prepubertal stage (GD 12 - PND 50) and group IV (WD/DMH/WD), received WD since pregnancy from dams (GD 12) until prepubertal stage (PND 50) and was reintroduced to WD during adulthood (PND 260). All groups were euthanized at the end of 50th week (PND 370). The colon was removed and the aberrant crypt foci (ACF) were stereoscopically and histologically scored for number, distribution and multiplicity. Neoplastic lesions and serum insulin and leptin concentrations were analysed at necropsy. ACF multiplicity and dysplastic lesions were significantly higher in the group fed WD during pregnancy until prepubertal stage (group III) than control group (group I). In the group III, the number of adenocarcinomas were higher than control (group I). In the group fed WD only in adulthood (group II), ACF multiplicity was significantly higher than in the control (group I). The group ...
CNPq: 142195/2010-3
FAPESP: 10/18827-0
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45

Jönsson, Maria. "The neuronal and non-neuronal substance P, VIP and cholinergic systems in the colon in ulcerative colitis." Doctoral thesis, Umeå universitet, Anatomi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19946.

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Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. Neuropeptides, especially vasoactive intestinal peptide (VIP) and substance P (SP), have long been considered to play key roles in UC. Among other effects, these neuropeptides have trophic and growth-modulating as well as wound-healing effects. Furthermore, whilst VIP has anti-inflammatory properties, SP has pro-inflammatory effects. It is generally assumed that the main source of SP and VIP in the intestine is the tissue innervation. It is not known whether or not they are produced in the epithelial layer. The details concerning the expressions of their receptors in UC are also, to a great extent, unclear. Apart from the occurrence of peptidergic systems in the intestine, there are also neuronal as well as non-neuronal cholinergic systems. The pattern concerning the latter is unknown with respect to UC. The studies in this thesis aimed to investigate the expression of SP and VIP and their major receptors (NK-1R and VPAC1) in UC colon, compared to non-UC colon. The main emphasis was devoted to the epithelium. A second aim was to examine for levels of these neuropeptides in blood plasma in UC. Another aim was to examine for the non-neuronal cholinergic system in UC, thus, to investigate whether there is acetylcholine production outside nerves in the UC colon. Methods used in the thesis were immunohistochemistry, in situ hybridization, enzyme immunosorbent assay, and in vitro receptor autoradiography. For the first time, mRNA for VIP and SP has here been found in the colonic epithelium. That was especially noted in UC mucosa showing a rather normal morphology, and in non-UC mucosa. Marked derangement of the mucosa was found to lead to a distinct decrease in VIP binding, and also a decrease in the expression level of VIP receptor VPAC1 in the epithelium. In general, there was an upregulation of the SP receptor NK-1R in the epithelium when the mucosa was deranged. The plasma levels of SP and VIP were higher for UC patients compared to healthy controls. There were marked correlations between the levels of the peptides in plasma, their levels in the mucosa and the degree of mucosal derangement/inflammation. A pronounced nonneuronal cholinergic system was found in both UC and non-UC colon. Certain changes occurred in this system in response to inflammation/derangement in UC. The present study shows unexpectedly that expressions for VIP and SP are not only related to the nerve structures and the inflammatory cells. The downregulation of VPAC1 expression, and the tendencies of upregulation of NK-1R expression levels when there is marked tissue derangement, may be a drawback for the intestinal function. The study also shows that there is a marked release of neuropeptides to the bloodstream in parallel with a marked derangement of the mucosa in UC. The cholinergic effects in the UC colon appear not only to be associated with nerverelated effects, but also effects of acetylcholine produced in local non-neuronal cells. The thesis shows that local productions for not only acetylcholine, but also SP and VIP, occur to a larger extent than previously considered.
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46

黃佩珊 and Pui-shan Helen Wong. "Study of the role of {221}-adrenoceptors in the promotion of colon cancer growth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3970743X.

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47

Coffindaffer, Jarrett W. "Colorectal cancer cost-effectiveness of screening and chemoprevention in average risk males /." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4633.

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Thesis (M.S.)--West Virginia University, 2006.
Title from document title page. Document formatted into pages; contains ix, 98 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 92-98).
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48

McEwan, David George. "Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival." Connect to e-thesis, 2007. http://theses.gla.ac.uk/81/.

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Thesis (Ph.D.) - University of Glasgow, 2007.
Thesis submitted in part fulfilment of the Ph.D. to The Beatson Institute for Cancer Research, Faculty of Medicine, University of Glasgow, 2007. Includes bibliographical references. Print version also available.
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González, Judith T. "Motivators for Colon Cancer Prevention Among Elderly Mexican Americans." University of Arizona, Mexican American Studies and Research Center, 1990. http://hdl.handle.net/10150/219035.

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This final report documents the theoretical development and preliminary empirical testing of a model that predicts the conditions under which Hispanics will seek preventive health care. Research shows that Hispanics delay preventive care, resulting in higher morbidity and mortality rates for serious diseases such as cancer. Since many serious diseases, such as heart disease, diabetes and cancer can be prevented or treated more effectively if detected early, it is crucial to understand the motivating forces behind Hispanics’ preventive health behavior. The Hispanic model, which is an extension of the Health Behavior in Cancer Prevention Model developed by Atwood, et al. (1986), includes as core variables environmental barriers to access and English-language proficiency, as well as social support, health beliefs, self-efficacy (or perceived skill), health locus of control, and health values. This correlational descriptive study employed snowballing sampling methods and consisted of 199 Hispanics between 49 and 94 years of age. Measures consist of multi-item scales whose content follows that of the Parent Project. The final instruments showed reliability (Alphas between .69 and .95), although the model testing was limited by the exclusion of some constructs that did not demonstrate reliability. The outcome of predisposition to self-care was predicted by utilization barriers to care, Chance Health Locus of Control, and General Health threat, resulting in an R-square of .07. The findings dealing with dietary preferences and preferred dietary modifications also have great implications for interventions aimed at preventing colon cancer among Hispanics. The practical health policy applications of the model are also discussed.
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Chan, Ling-fung. "Expression of the DNA mismatch repair protein MLH1 in serrated polyps of the colon : an immunohistochemical study /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35807581.

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