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Relevant bibliographies by topics / Colorectal tumorigenesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Colorectal tumorigenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Cripps, Kathryn Jane. "Genetic events in colorectal tumorigenesis." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/27836.

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More is known about the genes involved in colorectal tumorigenesis than for any other human cancer. Mutations have been identified in many genes, including the <I>K-ras</I> oncogene and the <I>APC, MCC, DC</I> and <I>p53</I> tumour suppressor genes. However, whilst much is known about these events there are many questions that remain unanswered. Three specific questions involving <I>p53, MCC</I> and <I>APC</I> were addressed in this thesis. Firstly, it has been previously assumed that point mutation of the <I>p53</I> gene inevitably resulted in a permanently stabilised protein product. To addr

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2

Kaidi, Abderrahmane. "The role of hypoxia in colorectal tumorigenesis." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439670.

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Moore, Amy Elizabeth. "The role of HGF/Met signalling in colorectal tumorigenesis." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544331.

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4

Chell, Simon D. "The role of prostaglandin synthesis and signalling in colorectal tumorigenesis." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413674.

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Jankowski, Janusz Antoni Zygmunt. "Constitutive gene expression during colorectal tumorigenesis : in vivo and in vitro." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321753.

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6

Morral, Martínez Clara 1989. "The Nucleolus : a connection between cell fate and tumorigenesis in colorectal cancer." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/663807.

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El càncer de colon es caracteritza per presentar una composició cel·lular heterogènia en la qual només un subgrup de cèl·lules retenen la capacitat de contribuir en el manteniment i creixement del tumor. L‘investigació duta a terme en aquesta tesis es focalitza en estudiar aquelles funcions biològiques que estan específicament enriquides en aquesta subpoblació tumoral comparat amb altres cèl·lules cancerígenes que no tenen potencial tumoral. A partir de dades obtingudes en analitzar l’expressió genètica de cèl·lules mare normals i tumorals, hem descobert que l’activitat nucleolar està espe

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7

Ilantzis, Christian. "Role of human carcinoembryonic antigen (CEA) in colorectal tumorigenesis : a tissue architecture model." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35898.

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Human carcinoembryonic antigen (CEA) and the related CEA family member nonspecific cross-reacting antigen (NCA), function in vitro as intercellular adhesion molecules. Changes in the expression pattern of CEA and NCA in a wide variety of cancerous tissues has raised the possibility that they could contribute to neoplastic and malignant transformation by influencing tissue architecture and differentiation. This study revisits the expression pattern of CEA and NCA in colorectal tumorigenesis by emphasizing the accurate quantitation of cell-surface levels in the context of tissue architecture. FA

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Ilantzis, Christian. "Role of human carcinoembryonic antigen (CEA) in colorectal tumorigenesis, a tissue architecture model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ50189.pdf.

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9

Kostic, Aleksandar David. "Deep Sequencing and Functional Analyses Identify a Role of Fusobacterium Species in Colorectal Tumorigenesis." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10843.

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The tumor microenvironment is a complex community consisting of neoplastic cells, surrounding stromal cells, a broad array of immune cells, and a microbiota. By sheer numbers, the microbiota has its greatest manifestation in colorectal cancer (CRC) because the colon contains up to 100 trillion bacteria, outnumbering human cells by a factor of 10 and encoding a gene-content that is 100-fold larger than that of the human genome. Indeed, previous studies using germ-free mice in a variety of genetic backgrounds have demonstrated that the microbiota can impact colorectal tumorigenesis. In addition,

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10

Okuchi, Yoshihisa. "Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis." Kyoto University, 2016. http://hdl.handle.net/2433/217738.

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11

Skeen, Victoria Rachel. "Investigating the functions of BAG-1 in colorectal tumorigenesis : implications of BAG-1-mediated suppression of TGF-B1 production." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535479.

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12

Coissieux, Marie-May. "Implication des récepteurs à dépendance de la nétrine-1 dans les cancers colorectaux." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10061.

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Les récepteurs à dépendance ont la particularité d’induire deux signalisations différentes en fonction de la disponibilité de leur ligand. En présence de leur ligand, ils initient une signalisation positive favorisant notamment la survie cellulaire tandis qu’en leur absence, ils induisent la mort de la cellule par apoptose. Ils créent donc un état de dépendance de la cellule vis-à-vis du ligand pour survivre. Cette dualité fonctionnelle leur confère un rôle central dans le maintien de l’homéostasie tissulaire chez l’adulte et particulièrement dans l’intestin et le colon. En ce sens, l’apoptose

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13

Crew, Tracey E. "The regulation of cyclooxygenase-2 in an in vitro model of colorectal tumorigenesis and mechanisms of action of potential chemopreventive agents." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311367.

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14

Thirlwell, C. "Mechanisms of colorectal tumorigenesis associated with Mut-Y (MYH) deficiency and identification of novel predisposition genes in the multiple adenoma phenotype." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444048/.

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The main subjects of my thesis can be divided into three related areas. Firstly, determination of the mechanisms of tumoriogenesis associated with a recently identified, recessively inherited syndrome, AfrTZ-associated polyposis (MAP). MAP results from defective base excision repair (BER) caused by bi-allelic germline mutations in the human Mut-Y homologue (MUTYH, MYH) and leads to the development of colorectal adenomas and cancer. My work includes: further characterisation of the MAP phenotype completion of screening for mutations in other BER enzymes (OGG1 and MTH1) in individuals with multi

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15

Flacelière, Maud. "La β-arrestine2, un acteur majeur de la tumorigenèse intestinale dépendante de la voie Wnt/β-caténine". Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20012/document.

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Les β-arrestines (Arrbs) régulent diverses voies de signalisation dont la voie Wnt/β-caténine (Wnt), un acteur clé dans le cancer colorectal. Le but de mon projet était d'étudier l'implication et les mécanismes régulés par les Arrbs dans la tumorigenèse intestinale dépendante de la voie Wnt. L'inhibition de l'expression des Arrbs partielle ou totale dans des souris ApcΔ14/+ montre que seules les souris invalidées pour l'Arrb2 développent 33% des tumeurs détectées chez les souris ApcΔ14/+ ; Arrb2+/+. Ces tumeurs ont une croissance normale. Cependant, l'analyse de leur transcriptome montre qu'el

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Quesada, Stanislas. "Recherche de nouveaux déterminants génétiques et épigénétiques de susceptibilité à la tumorigenèse intestinale au moyen du modèle murin Apcd14." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T013.

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Le cancer colorectal (CCR) représente un problème majeur de Santé publique. Des facteurs de risque environnementaux, ainsi que l'apparition séquentielle d'altérations génétiques et épigénétiques corrélant avec la progression tumorale ont été extensivement décrites. Cependant, les variations épigénétiques préexistant dans le tissu sain, potentiellement responsables de différences notoires de susceptibilité au CCR, sont restées élusives jusqu'à ce jour. Afin de répondre à cette problématique, la lignée murine Apcd14 (porteuse d'une mutation hétérozygote constitutive au niveau du gène Adenomatous

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Kantar, Diala. "L'étude fonctionnelle de la protéine d'échafaudage MAGI1 et de l'implication de la voie Hippo dans les cancers luminaux du sein et du colon." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT050.

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Au cours du développement, le comportement des cellules est étroitement régulé, ce qui assure un fonctionnement optimal des tissus épithéliaux sains. Les cellules épithéliales établissent ainsi des jonctions intercellulaires bien organisées, une polarité apico/basale, une architecture de la cytosquelette et intègrent des entrées régulatrices et homéostatiques relayées par des voies de signalisation dédiées. Les altérations de ces processus sont le plus souvent associées au cancer.Mon laboratoire s'intéresse au décryptage des mécanismes par lesquels les altérations de jonctions et de polarité s

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18

Yeh, Ching-Sheng, and 葉景生. "Molecular Mechanism of Tumorigenesis of Colorectal Cancers." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/66154132127440452726.

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博士<br>高雄醫學大學<br>醫學研究所博士班<br>96<br>Colorectal cancer (CRC) is the third most fatal cancer in Taiwan, next to liver cancer and lung cancer. Every year more than 7,000 people are diagnosed with the disease. There are four stages in the course of the disease: the 5-year survival rate of stage I CRC is about 90%, stage II is about 60-80%, stage III is about 30-60 %. At stage IV CRC, where distant metastasis occurs, the 5-year survival rate is reduced to 5%. The prevalence of CRC has increased gradually in recent years, therefore, effectively diagnosing and treating CRC is critical to identifying th

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Ou, Yu-Hsuan, and 歐俞萱. "The Role of Anillin in Tumorigenesis of Colorectal cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03424671078907288376.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>100<br>Colorectal cancer (CRC) is the third most prevalent cancer in the developed countries, accounting for more than 50,000 cancer deaths per year. About half of the patients with colorectal cancer can be cured by surgery and multimodal treatment. However, metastasis always leads to treatment failure. We used microarray to analyze the gene expression profiles of clinical specimens of colorectal cancer. Among 157 metastasis-related genes, RT-PCR and real-time PCR were used to verify 11 genes. The roles of anillin, one of 11 metastasis-associated genes, in colore

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Chang, Yun-Hsuan, and 張運玄. "Role of Haspin in tumorigenesis of human colorectal cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/48576507889668723276.

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碩士<br>國立交通大學<br>生物科技學系<br>104<br>Colorectal cancer (CRC) has become one of the highest rates of incidence and mortality in Taiwan and the world. Haspin is a Histone 3 phosphorylated kinase that promotes mitotic progression. However, the role of Haspin in CRC and whether the function can apply to be a treatment target is still unclear. In this study, we found Haspin proteins that were expressed in various human CRC cell lines, including HCT116, RKO and HT-29. FHC is a normal colon cell line that relatively expressed low level of Haspin proteins. The downstream protein levels of Survivin and H3T

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21

Chen, Chun Yu, and 陳俊宇. "Mechanism of phospholipid scramblase 1 (PLSCR1) involved in colorectal cancer tumorigenesis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/80217156696342615468.

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博士<br>長庚大學<br>生物醫學研究所<br>102<br>Phospholipid Scramblase 1 (PLSCR1) has been demonstrated overexpression in tissues of colorectal cancer. The purpose of this study is to examine the mechanism of PLSCR1 in CRC tumorigenesis. We compared the expression of PLSCR1, Src, Shc, Ras, Erk and cyclin D1 between colorectal carcinoma and adjacent normal mucosa by western blot. Totally, 22 pairs of tissues were observed that Src, Shc and cyclin D1 are significant up-regulated in colorectal carcinoma compare with normal tissue. PLSCR1 monoclonal antibody (PLSCR1 mAb) that binds to residues 1-30 of PLSCR1 rep

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22

Chia-ChunKuo and 郭家君. "Characterization of the role of hnRNPM isoforms in colorectal carcinoma tumorigenesis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/54y7sm.

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23

"The role of host defense peptide cathelicidin in colon tumorigenesis." 2012. http://library.cuhk.edu.hk/record=b5549651.

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宿主防御肽，如抗菌肽和防御素，是固有性免疫的重要组成部分。LL-37是由37个残基组成的阳离子宿主防御肽，是目前唯一被发现的人源宿主防御肽。它在不同的生物过程中都起着关键作用。新证据表明，LL-37与肿瘤进展也有关系。在许多类型的人类恶性肿瘤中它有不同表达，但在结肠癌中的表达和作用，仍未知。在此，我们将对LL-37及其17至32残基片断（简称FK-16）对结肠癌的影响进行研究。<br>免疫组化染色结果表明，LL-37在人类结肠癌组织中的表达比正常组织有显著减少。并且，LL-37的表达与TUNEL阳性细胞数量呈正比。合成的LL-37能够诱导不同的结肠癌细胞发生不依赖半胱天冬酶激活的凋亡细胞死亡。并且，LL-37通过激活p53下调Bcl2及上调Bax与Bak来诱导凋亡。LL-37也促使肿瘤坏死因子和核酸内切酶G 向核内转移，以其为目标的siRNA沉默能使细胞对LL-37诱导的凋亡呈现出耐受现象。更重要的是，LL-37的促凋亡作用被发现可以通过对百日咳敏感的Gαi蛋白偶联受体来介导。同时，宿主防御肽敲除的小鼠肠黏膜中，p53、Bax和Bak表达减少而Bcl2表达增加，凋亡的基础水平量也减少。由此说明，LL-37可通过激活GPCR-p53-Bax / Bak / Bcl-2的新信号级联反应来激活AIF / EndoG调控的结肠癌细胞凋亡。<br>与LL-37类似，其片断FK-16也促使不

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Göktuna, Serkan İsmail [Verfasser]. "The role of IKKalpha in sporadic and familial colorectal tumorigenesis / Serkan İsmail Göktuna." 2010. http://d-nb.info/1002657806/34.

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Shu-ChingLin and 林紓晴. "An autophagy up-regulated microRNA miR-449a participates in the tumorigenesis of colorectal cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/08782015783114037817.

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碩士<br>國立成功大學<br>微生物及免疫學研究所<br>101<br>Autophagy is a stress-induced catabolic process to degrade organelles, proteins and to release energy for maintaining cell survival. Autophagy either suppresses tumor formation or prevents cancer cells from starvation-related death. MicroRNAs (miRNAs) are small none coding RNAs, which bind to the 3'-UTR region of the target gene and cause degradation of mRNA or inhibition of translation. MiRNAs also play critical roles during cancer formation. However, the underlying mechanism remains elusive. We hypothesize that autophagy may affect tumorigenesis through r

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Chien-HsienLai and 賴謙賢. "HnRNP Q1 contributes to tumorigenesis through translational regulation of Aurora-A in colorectal cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/a642mg.

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Tai, Lin-Hsuan, and 戴琳諠. "To investigate the role of TREM-1 in tumor tumorigenesis of AOM/DSS-induced colorectal cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/8kjdr3.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>105<br>Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the rectum. Colorectal cancer is the third most common cause of cancer deaths worldwide. Risk factors include family history, environmental mutagens and the most important risk factors are specific intestinal microbes and chronic intestinal inflammation. Inflammation is a critical component for tumor progression. Chronic inflammation caused epithelial regeneration signal to activate, increased oxidative stress and pro-inflammatory cytokines (such as IL-6

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28

Su, Jun-Rong, and 蘇俊融. "Study on the potential gene network associated with phthalate exposure and tumorigenesis in colorectal cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/smj4jg.

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碩士<br>國立臺灣大學<br>生化科技學系<br>106<br>Phthalate or phthalate esters (PAEs) are widely used as plasticizers, which can be easily released into the environment. Phthalate can be directly absorbed through respiratory or digestive system. Phthalates are also endocrine-disrupting component and several studies regarding the effects of phthalate exposure are mainly focused on breast cancer, prostate cancer, reproductive toxicity and child development. However, the health effects of phthalate exposure on colorectal cancer are rarely discussed. Therefore, it is urgently needed to clarify the effect and mech

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Hsu, Pei Ting, and 徐珮婷. "Functional interrogation of novel Taiwanese-specific miR-1247-5p and miR-7974 regulatory networks in colorectal cancer tumorigenesis." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107CGU05114045%22.&searchmode=basic.

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"A novel link of Bcl-2 to TIGAR and NADPH regulation reveals the role of TIGAR in tumorigenesis." 2012. http://library.cuhk.edu.hk/record=b5549393.

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越來越多證據表明了煙酰胺腺嘌呤核苷酸磷酸（nicotinamide adenine dinucleotide phosphate, NADPH）代謝對腫瘤細胞增殖和生存的重要性。最近一項研究證實了一個p53調節基因，TP53誘導的糖酵解和凋亡調節因數（TP53-inducible glycolysis and apoptosis regulator, TIGAR），在抑制凋亡和誘導NADPH產生方面的作用。抗凋亡蛋白B細胞淋巴瘤2（B-cell lymphoma 2, Bcl-2）之前被報導能夠通過還未確定的機制誘導NADPH的產生。在這篇論文研究中，我們假設Bcl-2與TIGAR耦合從而調節NADPH的產生和細胞生存，並且TIGAR可能成為一個促進細胞生長的新生存因數。這篇論文研究的目的是：1）檢測在NADPH代謝中Bcl-2與TIGAR間的生物聯繫；2）探究在哺乳動物系統中TIGAR調節的分子機制；3）研究TIGAR在體外和體內調節正常及腫瘤細胞生存的作用。<br>這篇論文的第一部分結果顯示在正常小鼠胚胎成纖維細胞（MEFs）和缺少功能性p53的人非小細胞肺癌（NSCLC）細胞中存在Bcl-2/TIGAR/NADPH這樣一個新的信號通路軸，重要抗凋亡蛋白Bcl-2與TIGAR耦合後，以一個特有並持久的方式調節NADPH代謝和細胞生長。用特異的小干擾RNA（siRNA）靶向抑制B

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Duhamel, Stéphanie. "Implication de MEK1 et MEK2 dans l'initiation et la progression du cancer colorectal." Thèse, 2011. http://hdl.handle.net/1866/6244.

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Une dérégulation de la voie de signalisation Ras/Raf/MEK/ERK1/2 est observée dans plus de 30% des cancers et des mutations activatrices de RAS sont observées dans 30% à 50% des adénomes colorectaux. À la suite d’une analyse extensive de biopsies de tumeurs colorectales humaines par micromatrices tissulaires (TMA), nous avons observé que 44% des tissus cancéreux exprimaient MEK1/2 phosphorylés, contre 10% des tissus normaux. L'analyse des TMA a également révélé que 79% des tumeurs arboraient un marquage nucléaire de MEK1/2 phosphorylés, contre 4 % pour les tissus normaux. Bien que la voie MEK/E

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Soták, Matúš. "Úloha črevných cirkadiánnych hodín v epiteliálnom transporte, proliferácii a tumorigenéze." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338412.

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AABBSSTTRRAACCTT The molecular circadian clock enables anticipation of environmental changes. In mammals, clocks are ubiquitously present in almost all tissues and they are comprised of transcriptional-translational feedback loops of the so-called clock genes. The central clock represents the intrinsic pacemaker which is located in suprachiasmatic nuclei (SCN) of hypothalamus and synchronizes peripheral clocks. Clockwork system in alimentary tract and its regulatory link to intestinal functions are poorly understood. Therefore the objective of the thesis was to characterize molecular clock in

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Janečková, Lucie. "Signální dráha Wnt v obnově a tumorigenezi střevního epitelu." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338480.

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The canonical Wnt signaling pathway is one of the most important pathways involved in cell proliferation and differentiation. It is highly conserved in evolution and participates not only in embryonic development but also in adult tissue homeostasis. In the intestine, Wnt signaling is closely connected to maintenance of intestinal stem cells and renewal of the epithelia. Conversely, aberrant activation of the Wnt signaling pathway underlies different types of human diseases. Its constitutive activation results in neoplasia and specifically in development of colorectal cancer, which is the thir

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