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Journal articles on the topic 'Colour twinkling artifact'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kamal, Dr S. M. Sorowar, Prof Dr Md Abul Hossain, Dr Sheikh Rabeya Akter, Dr AFM Azizur Rahman Siddique, and Dr Mohammed Kamal Hossain. "Detection of the Renal Calculus by Twinkling Artifact in Color Doppler Ultrasonography." EAS Journal of Radiology and Imaging Technology 4, no. 6 (2022): 123–28. http://dx.doi.org/10.36349/easjrit.2022.v04i06.001.

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Introduction: Renal calculus is a solid mass of crystals that may block the urinary tract. Calcium and oxalate combine to create the majority of these crystals. These kidney stones pass via the urinary system to leave the body. Most stones may not certainly cause any symptoms or signs until they start moving toward the ureter. For detecting kidney stones twinkling artifact in Color Doppler Ultrasonography (CDU) is a useful sensitive instrument. The twinkling artifact's effect is highly dependent on machine settings and is probably created by phase (or clock) jitter. When illuminating specific

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2

Dr., Kaviya V. "Correlation of Ultrasound Twinkling Artifact with Dual Energy Computed Tomography in Characterization of Renal and Ureteric Calculi." International Journal of Medical and Pharmaceutical Research 4, no. 5 (2023): 124–31. https://doi.org/10.5281/zenodo.8360530.

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<strong>Background</strong>: The characterization of renal and ureteric calculi composition has been explored using various imaging techniques. The study aimed to assess the correlation of ultrasound twinkling artifacts with Dual Energy Computed Tomography (DECT) in this context.   <strong>Aims and Objectives: </strong>Establish the association between the composition of renal stones and the presence and grading of twinkling artifacts using color Doppler, in comparison with Dual Energy CT. Determine the sensitivity and specificity of ultrasound twinkling artifact vis-à-vis Dual Ene

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3

Gromov, A. I., Yu A. Komin, S. A. Mozerov, and S. K. Krasnickaya. "Twinkling artifact in differential diagnosis of mammary calcinates." Medical Visualization 25, no. 3 (2021): 157–66. http://dx.doi.org/10.24835/1607-0763-1025.

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Research goal: evaluation of the possibility of using an ultrasound twinkling artifact in the detection of breast calcifications as a diagnostic criterion for breast cancer.Material and methods. A targeted ultrasound study using color Doppler mapping was performed to determine the presence of a twinkling artifact in 112 patients who had calcifications detected during X-ray mammography.Results. According to the ultrasound examination, the twinkling artifact was registered only in 10 of the 112 women examined. A pronounced twinkling artifact was registered in 3 patients, the calcifications were

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4

Gliga, Mirela Liana, Cristian Nicolae Chirila, Daniela Maria Podeanu, et al. "Twinkle, twinkle little stone: an artifact improves the ultrasound performance!" Medical Ultrasonography 19, no. 3 (2017): 272. http://dx.doi.org/10.11152/mu-984.

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Aims: Ultrasound is a noninvasive method used for the diagnosis of urinary lithiasis. When the length of the stone is less than 5 mm, its detection may be difficult. The twinkling artifact (TwA) is an intense alternating color signal behind calcifications and stones in different organs. The aim of this paper was to evaluate the importance of the TwA in detecting kidney stones less than 5 mm in length. Material and methods: We examined 230 patients with lumbar pain or a history of kidney stones. We excluded patients with stones larger than 5 mm. 174 patients corresponded to the inclusion criter

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5

Sim, Hyun-Sun, and Kyung-Tae Kwon. "Usefulness of Twinkling Artifacts in Color Doppler Ultrasonography." Journal of the Korea Contents Association 16, no. 10 (2016): 291–98. http://dx.doi.org/10.5392/jkca.2016.16.10.291.

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6

Gulzar, Laraib, Muhammad Zubair, Maryam Tariq, et al. "B-Mode Sonography Versus Color Doppler Twinkling Artifact in the Diagnosis of Nephrolithiasis." Journal of Health and Rehabilitation Research 4, no. 2 (2024): 38–42. http://dx.doi.org/10.61919/jhrr.v4i2.736.

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Background: Nephrolithiasis, or kidney stones, is a prevalent condition that prompts numerous patient visits to emergency departments worldwide. The diagnosis of this condition and its complications, such as hydronephrosis, has traditionally relied on various imaging modalities, with ultrasound being a primary, non-invasive option. Recent advancements, including the utilization of the color Doppler twinkling artifact, have potentially enhanced the diagnostic capabilities of ultrasound for nephrolithiasis. Objective: This study aims to evaluate the effectiveness of B-mode sonography and the col

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7

Rokni, Eric, and Julianna C. Simon. "The effect of surface tension on the color Doppler ultrasound twinkling artifact." Journal of the Acoustical Society of America 151, no. 4 (2022): A31. http://dx.doi.org/10.1121/10.0010562.

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Imaging crystalline structures with Doppler ultrasound can produce a rapid color shift, termed the twinkling artifact, that can assist in diagnosing pathological mineralizations such as kidney stones, heterotopic ossification, gout, and breast microcalcifications. Twinkling is theorized to arise from scattering off surface crevice microbubbles, which are affected by the surface tension between the bubble and surrounding medium. In this study, we evaluated the effect of surface tension on twinkling in pure crystals. Cholesterol, calcium phosphate, and uric acid crystals were grown in vitro (n =

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8

Rokni, Eric, and Julianna C. Simon. "The effect of gas composition on the color Doppler ultrasound twinkling artifact." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A355. http://dx.doi.org/10.1121/10.0019136.

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The twinkling artifact, or twinkling, appears when imaging kidney stones and other mineralizations with Doppler ultrasound and is caused by scattering off crevice microbubbles. Previous work found that twinkling on in vivo kidney stones increased or decreased with elevated oxygen or carbon dioxide, respectively. However, it is unclear whether these results are from biological adaptions to the changing respiratory gas and thus if in vitro mineralizations are similarly affected. Here, cholesterol, calcium phosphate, and uric acid crystals were grown in vitro and imaged in deionized water using a

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9

Kitur, Eusila C., Eric Rokni, and Julianna C. Simon. "The Doppler ultrasound twinkling artifact on crevices etched in silicon wafers." Journal of the Acoustical Society of America 152, no. 4 (2022): A293. http://dx.doi.org/10.1121/10.0016322.

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The twinkling artifact, or rapid color shifts, are observed when imaging kidney stones and other mineralizations. The current theory is that scattering from bubbles in micron-sized crevices causes twinkling. Our objective is to investigate the effect of ultrasound frequency and crevice size and number on twinkling of silicon wafers. Ten or 100 randomly positioned cylindrical crevices with diameters of 1, 10, or 100 μm and depths of 10 μm were dry-etched on wafers. A research ultrasound system was used to image wafers at 5, 7.8, and 18.5 MHz; IQ data were post-processed to calculate twinkling o

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10

Rahmouni, A., R. Bargoin, A. Herment, N. Bargoin, and N. Vasile. "Color Doppler twinkling artifact in hyperechoic regions." Radiology 199, no. 1 (1996): 269–71. http://dx.doi.org/10.1148/radiology.199.1.8633158.

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11

Tsao, Teng-Fu, Ruei-Jin Kang, Mein-Kai Gueng, Yeu-Sheng Tyan, Yung-Chang Lin, and San-Kan Lee. "Color Doppler Twinkling Artifact and Clinical Use." Journal of Medical Ultrasound 17, no. 3 (2009): 157–66. http://dx.doi.org/10.1016/s0929-6441(09)60122-3.

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12

Ryazanov, Vladimir V., Gulnaz K. Sadykova, Igor S. Zheleznyak, et al. "Informativeness of the doppler twinkling artifact in the diagnosis of urinary tract calculi." Russian Military Medical Academy Reports 42, no. 3 (2023): 285–92. http://dx.doi.org/10.17816/rmmar528480.

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The kidney stone disease (nephrolithiasis, urolithiasis) is a common urological problem that affects both adults and children and has a high recurrence rate. Early and reliable imaging diagnosis of urolithiasis is important for early pain relief and the avoidance of complications that require surgical intervention. Non-contrast computed tomography is considered the method of choice in the diagnosis of urolithiasis, however, this method is associated with exposure to ionizing radiation. Ultrasound diagnostics or sonography, in contrast, is considered as the method of early diagnosis of urolithi

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13

LOUVET, ARNAUD. "TWINKLING ARTIFACT IN SMALL ANIMAL COLOR-DOPPLER SONOGRAPHY." Veterinary Radiology Ultrasound 47, no. 4 (2006): 384–90. http://dx.doi.org/10.1111/j.1740-8261.2006.00158.x.

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14

Ozkur, Ayhan, Ebru Dikensoy, Selim Kervancioglu, Resat Kervancioglu, Serhat İnalöz, and Metin Bayram. "Color Doppler twinkling artifact in intrauterine fetal demise." Journal of Clinical Ultrasound 36, no. 3 (2008): 153–56. http://dx.doi.org/10.1002/jcu.20381.

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15

Bönhof, Jörg, and Glen McLaughlin. "Artifacts in Sonography – Part 3." Ultraschall in der Medizin - European Journal of Ultrasound 39, no. 03 (2018): 260–83. http://dx.doi.org/10.1055/a-0594-2196.

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AbstractAs a continuation of parts 1 1 and 2 2, this article discusses artifacts as caused by insufficient temporal resolution, artifacts in color and spectral Doppler sonography, and information regarding artifacts in sonography with contrast agents. There are artifacts that occur in B-mode sonography as well as in Doppler imaging methods and sonography with contrast agents, such as slice thickness artifacts and bow artifacts, shadows, mirroring, and artifacts due to refraction that appear, for example, as double images, because they are based on the same formation mechanisms. In addition, th

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16

Ruge-Jones, Lucas, Lisa Berntsen, Fea Morgan-Curtis, Daniel Hayes, and Julianna C. Simon. "Investigating the color Doppler twinkling artifact as an early detector of cellular mineralization." Journal of the Acoustical Society of America 151, no. 4 (2022): A32. http://dx.doi.org/10.1121/10.0010563.

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Heterotopic ossification (HO) occurs when bone develops in areas where bone does not usually exist, often appearing after blast injuries or other musculoskeletal trauma. Current methods of diagnosis, such as three-phase bone scintigraphy, x-ray, or CT scans, take several weeks after the trauma before HO is visible. The color Doppler ultrasound twinkling artifact has been shown to detect the presence of kidney stones and other crystals. Twinkling could provide a more sensitive method of HO detection, which would allow for earlier diagnosis and treatment and limit HO severity. In our research, h

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17

Wood, Benjamin, Renc Saracaydin, Christine Lee, and Matthew W. Urban. "Using 3D printed structures to evaluate the potential causes of the color Doppler twinkling signature." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A355. http://dx.doi.org/10.1121/10.0019138.

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The color Doppler twinkling artifact has been attributed to existing microbubbles or cavitation occurring on objects like kidney stones, some breast biopsy markers, and sandpaper. The grooves of helical constructs that twinkle may provide sufficient locations for bubble retention and/or cavitation. We developed six half-cylinders that replicate the geometry of twinkling helical constructs with a micro 3D-printing process to explore how their characteristics relate to twinkling. Four copies of each design including a control were created. The cylinders had pitch (groove-to-groove distance) of 8

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18

Ustymowicz, Andrzej, Jaroslaw Krejza, and Zofia Mariak. "Twinkling Artifact in Color Doppler Imaging of the Orbit." Journal of Ultrasound in Medicine 21, no. 5 (2002): 559–63. http://dx.doi.org/10.7863/jum.2002.21.5.559.

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19

Yanik, Bahar, Işik Conkbayir, Esįn Çakmakçi, and Baki Hekįmoğlu. "Color Doppler twinkling artifact in a calcified liver mass." Journal of Clinical Ultrasound 33, no. 9 (2005): 474–76. http://dx.doi.org/10.1002/jcu.20172.

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20

Choi, Min Joo, Chang Hee Cho, Gwansuk Kang, and Jeonghwa Yang. "Color Doppler twinkling artifact: Possible mechanisms and clinical potential." Biomedical Engineering Letters 4, no. 1 (2014): 41–54. http://dx.doi.org/10.1007/s13534-014-0124-4.

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21

Kim, Hyun Cheol, Dal Mo Yang, Sang Won Kim, Seong Jin Park, and Jung Kyu Ryu. "Color Doppler Twinkling Artifacts in Small-Bowel Bezoars." Journal of Ultrasound in Medicine 31, no. 5 (2012): 793–97. http://dx.doi.org/10.7863/jum.2012.31.5.793.

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22

Zinck, Scott A., and Julianna Simon. "Characterizing tissue calcifications using the color Doppler ultrasound twinkling artifact." Journal of the Acoustical Society of America 144, no. 3 (2018): 1925. http://dx.doi.org/10.1121/1.5068431.

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23

Zinck, Scott A. "Etiology of the color Doppler twinkling artifact on kidney stones." Journal of the Acoustical Society of America 145, no. 3 (2019): 1922. http://dx.doi.org/10.1121/1.5101982.

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24

Lee, Jae Young, Seung Hyup Kim, Jeong Yeon Cho, and Daehee Han. "Color and Power Doppler Twinkling Artifacts from Urinary Stones." American Journal of Roentgenology 176, no. 6 (2001): 1441–45. http://dx.doi.org/10.2214/ajr.176.6.1761441.

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25

Yu, M. H., J. Y. Lee, S. H. Kim, et al. "Value of Color Doppler Twinkling Artifacts from Gallbladder Adenomyomatosis." Ultrasound in Medicine & Biology 37, no. 8 (2011): S68—S69. http://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.314.

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26

Morgan-Curtis, Fea, Lucas Ruge-Jones, Grace M. Wood, et al. "Ultrasound diagnosis and treatment of heterotopic ossification." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A326. http://dx.doi.org/10.1121/10.0027686.

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Heterotopic ossification (HO), or the presence of bone in soft tissues, can occur after musculoskeletal trauma, causing pain and reduced mobility. However, even the most sensitive diagnostic modality requires 2–3 weeks after initiation to detect HO, and the only treatment is surgical resection after HO matures (&gt;2 years). Here, we evaluate the color Doppler ultrasound twinkling artifact for early diagnosis of HO and focused ultrasound (fUS) for treatment of early HO. We began by evaluating twinkling and fUS parameters in ossified cell culture. We then evaluated imaging and treatment par

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27

高, 海港. "The Characterization of Color Doppler Ultrasound Twinkling Artifact in Ureteral Calculi." Advances in Clinical Medicine 12, no. 07 (2022): 6384–90. http://dx.doi.org/10.12677/acm.2022.127920.

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28

Tsao, T. F., R. J. Kang, Y. S. Tyan, M. K. Gueng, T. Lee, and S. K. Lee. "Color Doppler twinkling artifact related to chronic pancreatitis with parenchymal calcification." Acta Radiologica 47, no. 6 (2006): 547–48. http://dx.doi.org/10.1080/02841850600690371.

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29

Ozan, Ebru, Gokce Kaan Atac, and Sadi Gundogdu. "Twinkling artifact on color Doppler ultrasound: an advantage or a pitfall?" Journal of Medical Ultrasonics 43, no. 3 (2016): 361–71. http://dx.doi.org/10.1007/s10396-016-0715-z.

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30

Brownstead, Laura, Necole Streeper, and Julianna C. Simon. "The effect of elevated oxygen on kidney stone twinkling in vivo and ex vivo." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A355. http://dx.doi.org/10.1121/10.0019137.

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The Doppler ultrasound twinkling artifact is a rapid color shift observed in ∼66% of kidney stones. Breathing oxygen at elevated pressures was shown to enhance twinkling on kidney stones in human subjects. Here, in humans and in ex vivo stones, we investigate the effects of elevated oxygen at ambient pressure. Recruited subjects with confirmed stones were scanned with a research ultrasound system and Philips/ATL C5-2 transducer while breathing ambient air for 2 min. Then, subjects were masked with 100% oxygen for 15 min and scanned again for the last 2 min. Similarly, ex vivo stones were image

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31

KUJIRAOKA, Yuka, Yuichi DAI, Emika ICHIOKA, Tatsuhiko IKEDA, and Hisato HARA. "A case of breast cholesterol granuloma presenting twinkling artifact on color Doppler sonography." Choonpa Igaku 41, no. 6 (2014): 867–70. http://dx.doi.org/10.3179/jjmu.jjmu.a.26.

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32

Rokni, Eric, Scott Zinck, and Julianna C. Simon. "Evaluation of Stone Features That Cause the Color Doppler Ultrasound Twinkling Artifact." Ultrasound in Medicine & Biology 47, no. 5 (2021): 1310–18. http://dx.doi.org/10.1016/j.ultrasmedbio.2021.01.016.

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33

Jeon, Se Jeong, and Seong Eon Yoon. "Color Doppler Twinkling Artifact in Hepatic Bile Duct Hamartomas (von Meyenburg Complexes)." Journal of Ultrasound in Medicine 25, no. 3 (2006): 399–402. http://dx.doi.org/10.7863/jum.2006.25.3.399.

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34

Bacha, Raham, SyedAmir Gilani, and Iqra Manzoor. "Relation of color doppler twinkling artifact and scale or pulse repetition frequency." Journal of Medical Ultrasound 27, no. 1 (2019): 13. http://dx.doi.org/10.4103/jmu.jmu_129_18.

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35

Simon, Julianna C., Bryan W. Cunitz, Oleg A. Sapozhnikov, et al. "The effect of ambient pressure on the color Doppler ultrasound twinkling artifact." Journal of the Acoustical Society of America 138, no. 3 (2015): 1746. http://dx.doi.org/10.1121/1.4933510.

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36

Sorensen, Mathew D., Jonathan D. Harper, Ryan S. Hsi, et al. "B-mode Ultrasound Versus Color Doppler Twinkling Artifact in Detecting Kidney Stones." Journal of Endourology 27, no. 2 (2013): 149–53. http://dx.doi.org/10.1089/end.2012.0430.

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37

Kamaya, Aya, Theresa Tuthill, and Jonathan M. Rubin. "Twinkling Artifact on Color Doppler Sonography: Dependence on Machine Parameters and Underlying Cause." American Journal of Roentgenology 180, no. 1 (2003): 215–22. http://dx.doi.org/10.2214/ajr.180.1.1800215.

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38

Rokni, Eric, Scott A. Zinck, and Julianna C. Simon. "The effect of crystal chemical composition on the color Doppler ultrasound twinkling artifact." Journal of the Acoustical Society of America 145, no. 3 (2019): 1922–23. http://dx.doi.org/10.1121/1.5101983.

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39

Davran, Ramazan. "The usefulness of color Doppler twinkling artifact in the diagnosis of urinary calculi." European Journal of Radiology 71, no. 2 (2009): 378. http://dx.doi.org/10.1016/j.ejrad.2008.06.021.

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40

Kim, Hyun Cheol, Dal Mo Yang, Wook Jin, Jung Kyu Ryu, and Hyeong Cheol Shin. "Color Doppler Twinkling Artifacts in Various Conditions During Abdominal and Pelvic Sonography." Journal of Ultrasound in Medicine 29, no. 4 (2010): 621–32. http://dx.doi.org/10.7863/jum.2010.29.4.621.

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41

Yang, Jeong-hwa, Gwansuk Kang, and Min Joo Choi. "The role of the acoustic radiation force in color Doppler twinkling artifacts." Ultrasonography 34, no. 2 (2015): 109–14. http://dx.doi.org/10.14366/usg.14065.

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42

Gao, Jing, Keith Hentel, and Jonathan M. Rubin. "Correlation Between Twinkling Artifact and Color Doppler Carrier Frequency: Preliminary Observations in Renal Calculi." Ultrasound in Medicine & Biology 38, no. 9 (2012): 1534–39. http://dx.doi.org/10.1016/j.ultrasmedbio.2012.04.011.

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43

Gao, Jing, Amelia Ng, Minh-Nhut Y. Dang, and Robert Min. "Flow turbulence or twinkling artifact? A primary observation on the intrarenal color Doppler sonography." Clinical Imaging 34, no. 5 (2010): 355–60. http://dx.doi.org/10.1016/j.clinimag.2009.08.029.

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44

Simon, Julianna C., Barbrina Dunmire, Bryan Cunitz, et al. "Etiology of the color Doppler ultrasound twinkling artifact on in situ human kidney stones." Journal of the Acoustical Society of America 142, no. 4 (2017): 2696. http://dx.doi.org/10.1121/1.5014835.

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45

Su, Chun-Hung, Shu-Ping Wu, Yi-Jui Huang, Teng-Fu Tsao, and Yeu-Sheng Tyan. "An In vitro Study of Guidewire-Related Color Doppler Twinkling Artifacts in Echocardiography." Journal of Medical Ultrasound 26, no. 4 (2018): 200. http://dx.doi.org/10.4103/jmu.jmu_23_18.

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46

Yu, Mi Hye, Jae Young Lee, Jeong-Hee Yoon, Jee Hyun Baek, Joon Koo Han, and Byung-Ihn Choi. "Color Doppler Twinkling Artifacts from Gallbladder Adenomyomatosis with 1.8 MHz and 4.0 MHz Color Doppler Frequencies." Ultrasound in Medicine & Biology 38, no. 7 (2012): 1188–94. http://dx.doi.org/10.1016/j.ultrasmedbio.2012.03.010.

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47

Chelfouh, N., N. Grenier, D. Higueret, et al. "Characterization of urinary calculi: in vitro study of "twinkling artifact" revealed by color-flow sonography." American Journal of Roentgenology 171, no. 4 (1998): 1055–60. http://dx.doi.org/10.2214/ajr.171.4.9762996.

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48

Trillaud, Hervé, Jean-Louis Pariente, Abdelhack Rabie, and Nicolas Grenier. "Detection of Encrusted Indwelling Ureteral Stents Using a Twinkling Artifact Revealed on Color Doppler Sonography." American Journal of Roentgenology 176, no. 6 (2001): 1446–48. http://dx.doi.org/10.2214/ajr.176.6.1761446.

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49

Chelfouh, N., N. Grenier, D. Higueret, et al. "Characterization of Urinary Calculi: In Vitro Study of “Twinkling Artifact” Revealed by Color-Flow Sonography." Journal of Urology 161, no. 4 (1999): 1399–400. http://dx.doi.org/10.1016/s0022-5347(01)61710-5.

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50

Chelfouh, N., N. Grenier, D. Higueret, et al. "Characterization of Urinary Calculi: In Vitro Study of “Twinkling Artifact” Revealed by Color-Flow Sonography." Journal of Urology 162, no. 2 (1999): 632. http://dx.doi.org/10.1016/s0022-5347(05)68659-4.

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