To see the other types of publications on this topic, follow the link: Colposcopy guided biopsy.
Journal articles on the topic 'Colposcopy guided biopsy'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Colposcopy guided biopsy.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Guptha, Sindhu C. "Evaluation of cervical erosion in symptomatic women." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (2020): 2035. http://dx.doi.org/10.18203/2320-1770.ijrcog20201801.
Full textAbstract:
Background: The objective of this study was evaluation of symptomatic women with cervical erosion.Methods: Prospective clinical study done in the department of obstetrics and gynecology, VIMS, Ballari for one-year period from June 2016 to May 2017. All patients with symptoms of white discharge, post coital bleeding and menstrual irregularities were examined by per speculum examination and all those who had cervical erosion (112 Patients) were included in the study. Pap smear and colposcopy were done in all subjects. Colposcopic guided biopsy was done in women with abnormal findings on colposcopy. Histological prediction of colposcopic findings was done according to the Reid’s modified colposcopic index. The result of the biopsy was correlated with the predicted histology of the Reid’s modified colposcopic index and statistical analysis done to calculate diagnostic efficacy of colposcopy in the evaluation of symptomatic women with cervical erosion.Results: Out of the 112 patients, 5.35% (6/112) had abnormal Pap smear. All patients underwent colposcopy and colposcopic guided biopsy, 11.6% (13/112) had abnormal colposcopic findings. Histopathology confirmed CIN I in 6.25% (7/112) and CIN II in 1.78% (2/112) patients. The sensitivity, specificity, PPV, NPV and accuracy of PAP smear was found to be 22.22%, 96.11%, 33.33%, 93.39% and 90.17%. The above values for colposcopy were found to be 88.89%, 95.15%, 61.54%, 98.99% and 94.64%.Conclusions: Colposcopy should be done in all symptomatic patients with cervical erosion as it is a good diagnostic tool for premalignant conditions of the cervix and correlates well with histopathological findings.
2
Gandavaram, Jyothi, and Bindu Reddy Pamulapati. "Correlation of Pap smear and colposcopic findings in relation to histopathological findings among women attending a tertiary care hospital: a two year study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 6 (2019): 2163. http://dx.doi.org/10.18203/2320-1770.ijrcog20192132.
Full textAbstract:
Background: Cervical malignancy is ranked second among the malignancies in females with breast carcinoma the first. Screening for cervical cancer by conventional cytology and supported by colposcopy and histopathology can easily identify the premalignant lesions and also other non-invasive inflammatory lesions of the cervix. Objective of this study was to find the correlation of Pap smear, colposcopic findings and colposcopic guide biopsy in evaluation of cervical lesions in women and to analyze the various risk factorsMethods: A prospective study for two years was conducted by department of obstetrics among women aged from 20-60 years. Socio demographic data, clinical history and examination were done and findings noted. Pap smear, colposcopy and colposcopic guided biopsy was done and findings were noted and analyzed foe sensitivity, specificity and compared with Pap smear.Results: In present study sensitivity of Pap smear for detecting lesions above LSIL was 28%, specificity 99.32%, PPV was 93.47%, negative predictive value 76.21% and accuracy of Pap smear was 78%. The sensitivity of colposcopy in detection of low grade lesions and above came out to be 80.2%, specificity 82.14%, positive predictive value 66.78%, negative predictive value 86.78% and accuracy of colposcopy was 84.65%.The incidence of preinvasive lesions (LSIL and HSIL) was 33.6% with LSIL (19.2%) and HSIL (14.4%) and of invasive lesions was 9.6%.Conclusions: This study suggests that accuracy of detection of cervical abnormalities is higher when cytology, colposcopic biopsy and colposcopy are used complimentarily in diagnosis of cervical lesions. Colposcopy eliminates the need for repeated follow up as in Pap smear which has low sensitivity.
3
Patil, Pooja, and Priyanka Sharma. "Colposcopic evaluation of cervical erosion in symptomatic women." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 6 (2017): 2207. http://dx.doi.org/10.18203/2320-1770.ijrcog20172025.
Full textAbstract:
Background: This study was carried out to find the colposcopic findings in the symptomatic patients with cervical erosion and correlate the findings with cytology and histopathology.Methods: All the patients coming to gynaecological OPD with symptoms of white discharge, pruritus vulvae, menstrual irregularities were examined by per speculum examination and all those who had cervical erosion were included in the study and pap smear and colposcopy both were done in all subjects. The colposcopic guided biopsy was done in women with abnormal findings on colposcopy (50 women) and reports were compared. Abnormal colposcopic findings were graded according to Reid’s colposcopic index (RCI).Results: Majority of patients came with the complaint of white discharge per vaginum (55%).Out of 120 patients, 85 women (70.9%) had inflammatory pap smear and 35 women (29.1%)had abnormal pap smear. All patients underwent colposcopic examination and out of 120 patients, 67(55.8%) showed normal colposcopic findings and 50 women (41.6%) had abnormal colposcopic finding and biopsy was taken. 3 women had unsatisfactory colposcopy. Histopathology confirmed 24 (48%) women with CIN I and 12 (24%) CIN II and 6 (12%) CIN III and 2 (4%) women with carcinoma cervix. The colposcopy findings and histopathology correlated in 88%.Conclusions: Colposcopy should be prescribed to all symptomatic patients with cervical erosion as it is a good diagnostic tool for pre-malignant conditions of cervix and correlates well with histopathological findings.
4
Subramanyam, Bhanu Rekha, and Hemasree Garlapati. "Comparative study of pap smear and colposcopy guided biopsy in a district medical college." International Journal Of Community Medicine And Public Health 7, no. 1 (2019): 279. http://dx.doi.org/10.18203/2394-6040.ijcmph20195867.
Full textAbstract:
Background: Cancer cervix is the second most gynaecological and in India, one in fifty women suffer with cancer cervix and hence intense screening is mandatory.Methods: This prospective study was conducted in SVS Medical College, a district tertiary centre. 100 women who presented to gynaecology outpatient department who fulfilled all the inclusion criteria were subjected to pap smear and colposcopic guided biopsy. The data was correlated and compared to critically evaluate the sensitivity and specificity of colposcopy versus Pap smear in the early detection of dysplasia.Results: Colposcopy has far better sensitivity than Pap smear and almost negligible difference in specificity.Conclusions: Colposcopy is definitely more sensitive and accurate than pap smear and can be included as the primary screening in district hospitals as a primary screening tool in detecting cancer cervix.
5
Smailova, S. B., N. A. Shanazarov, T. G. Grishacheva, S. Zh Salmagambetova, and G. S. Aldabergen. "Possibilities of fluorescence diagnostics in detecting multicentric focies of cervical dysplasia." Biomedical Photonics 12, no. 3 (2023): 11–14. http://dx.doi.org/10.24931/2413-9432-2023-12-3-11-14.
Full textAbstract:
Colposcopy allows the examiner to localize potential lesions, assess the severity of the lesion, and obtain a colposcopic guided biopsy. This method has limited sensitivity and specificity, raising serious concerns about the possibility of missing cervical dysplasia. Fluorescent methods for diagnosing precancerous diseases of the cervix and early forms of cancer have an extremely high sensitivity, reaching 90%. The presented results of the study allow us to fully declare the high information content of fluorescent colposcopy in identifying dysplastic lesions on the cervix.
6
Islam, Farjana, and Chowdhury Shamima Sultana. "Colposcopic Findings for Detecting Pre-invasive Lesion of Cervix Among Visually Inspected Acetic Acid Positive Cases." Bangladesh Medical Research Council Bulletin 48, no. 1 (2022): 27–32. http://dx.doi.org/10.3329/bmrcb.v48i1.60657.
Full textAbstract:
Background: Cervical cancer-a preventable disease, is the second most commonly diagnosed cancer among women of developing countries. Paps smear is the gold standard screening method worldwide. But a low-cost test, visual inspection of cervix with acetic acid (VIA) has been emerged as an alternative for use in lowresource settings. VIA is simple and easy to perform by auxiliary health professionals. Colposcopy is an essential procedure in the evaluation of screen positive cervix though it requires considerable training and experience. Objective: The objective of this study was to evaluate the VIA positive cases by colposcopy, colposcopy guided biopsy and histopathological examination. Methods: This was a cross sectional observational study conducted among 100 VIA positive cases attended at GOPD of Dhaka Medical College Hospital from July 2014 to December 2014. Colposcopy was performed in all VIA positive cases. Subsequent biopsy and histopathological examinations were done for those with colposcopic abnormal findings. Results: The mean age of the study population was 37.9±9.3 years. Among VIA positive cases 66.0% had complaints of whitish vaginal discharge. Among the study population, colposcopically 46.0% had healthy cervix (normal) and 54.0% had abnormal findings. Colposcopy guided biopsy was taken from those with abnormal findings. Histopathological findings were normal in 38.9% cases, chronic cervicitis in 20.37% cases, squamous cell metaplasia in 3.7% cases, CIN I in 16.7%, CIN II in11.11%, CIN III in 5.6% and 3.7% cases were carcinoma cervix. True positive value was 20, false positive value 34 and positive predictive value of colposcopy was 37.03%. Conclusion: This study concluded that VIA is effective in detection of CIN and invasive carcinoma of cervix. It also suggests the role of colposcopy in the evaluation of CIN and other cervical diseases in screen positive cases. VIA can be used as a screening tool in low and middle income countries like Bangladesh, not only in rural areas and small health centres, but also in hospitals, cancer institutes, and other health facilities with better resources. Bangladesh Med Res Counc Bull 2022; 48(1): 27-32
7
Gyawali, P., S. R. KC, and S. Ghimire. "Role of Colposcopy in Detection of Dysplastic Cervical Lesion as a Screening Tool." Journal of Global Oncology 4, Supplement 2 (2018): 33s. http://dx.doi.org/10.1200/jgo.18.51300.
Full textAbstract:
Background: Age standardized cervical cancer incidence rate in Nepal is 19.2/100,000 woman, compared with 14.0 worldwide. Similarly, mortality rate is 12.0 women which is significant in comparison with 6.8 worldwide. Cervical intraepithelial neoplasm is a precursor lesion, having high transformation rate into the cervical carcinoma. Data clearly indicates that CIN 2 and 3 has more progression into cervical carcinoma. Despite the fact that Papanicolaou test has remained an important tool in the screening for cervical cancer and has contributed in significant decrease in cervical cancer, sensitivity and specificity of conventional Papanicolaou test is quite low. Colposcopy is visual inspection of cervix under magnification. Study revealed that the positive predictive rate of the colposcopic impression is better as the cervical lesion is more severe. Aim: To find out the significance of colposcopy in the detection of dysplastic cervical lesions and possible use of this method as a screening tool. Methods: This is an observational study done at Cancer Care Foundation, Nepal done from a period of January 2015 to February 2018. Permission was obtained from ethical committee and written consent was obtained from the patients. All the patients suspected having dysplastic or invasive lesions or in whom colposcopy-guided biopsy was performed; were included in the study. Relevant data were collected which included age, colposcopic diagnosis, histopathological diagnosis. Data were entered into Microsoft Excel and statistical analysis was done from statistical package SPSS 21. Results: 6109 females were screened through colposcopy. Out of these 900 patients underwent colposcopy-guided biopsy for being suspected of dysplastic lesions or inflammatory lesions. Mean age of females was 40.65 years. With colposcopy, 407 (45.2%) were suspected to have low grade lesion, followed by 401 (44.6%) high grade lesion and 15 (1.7%) carcinoma. Nonneoplastic lesions were suspected in 77 (8.6%) females. In the histopathological examination low grade dysplasia was observed in 403 (44.8%) followed by 250 (27.8%) high grade dysplasia and 8 (0.9%) carcinoma in-situ or invasive carcinoma. Similarly, 239 (26.6%) patients had nonneoplastic lesions. In colposcopy, high grade lesions were suspected more frequently in females of 41-50 years age group than in 31-40 years age group ( P < 0.01). Correlation between increasing age and dysplastic lesions were also observed ( P < 0.05). There was significant correlation between colposcopic diagnosis and histopathological diagnosis with a P value < 0.01. The sensitivity of colposcopy to diagnose dysplastic lesions were high 96.44% with positive predictive value of 62.65%. The specificity of colposcopy to diagnose various grades of dysplastic lesions is 34.98%. Conclusion: Colposcopy is highly sensitive method of screening dysplastic cervical lesions and should be used more frequently as a screening purpose.
8
Marcos Lopes, Ana Cristina, Adriana Bittencourt Campaner, and Laílca Quirino Henrique. "Prevalence of High-Grade Intraepithelial Neoplasia in Patients with Cytology Presenting Atypical Squamous Cells of Undetermined Significance." Acta Cytologica 60, no. 2 (2016): 139–44. http://dx.doi.org/10.1159/000446206.
Full textAbstract:
Objectives: To evaluate the prevalence of histological high-grade lesions and cervical cancer in patients with ASCUS cytology. Methods: This is a cross-sectional prospective study involving 703 women with a uterus and atypical squamous cells of undetermined significance (ASCUS). The patients were submitted to a colposcopy and underwent a guided biopsy when changes on the colposcopy were detected. Results: The findings revealed 456 (64.9%) women with a normal colposcopy and 247 (35.1%) with colposcopic abnormalities. The biopsy results were: cervical intraepithelial neoplasia grade 1 (CIN 1) in 51 (20.6%) patients, CIN 2 in 11 (4.5%) patients, CIN 3 in 8 (3.2%) patients, and a negative result in 177 (71.7%) patients; no cases of cancer were detected. Tallying of 456 normal colposcopies and 177 negative biopsies yielded a total of 90.04% negative exams. Furthermore, around 7.2% (51/703) of the patients exhibited CIN 1, a lesion associated with a high potential for regression. The biopsy results were not associated with patient age or menopausal status. Conclusion: We conclude that cytological surveillance of patients with ASCUS is feasible and safe given the low risk of CIN 2/3 or cervical cancer.
9
Baranwal, Nilakshi, Rupali Sharma, Rachna, and Megha Agarwal. "Clinical outcome of colposcopy guided biopsy in women with abnormal Pap smear results." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 14, no. 2 (2025): 529–34. https://doi.org/10.18203/2320-1770.ijrcog20250188.
Full textAbstract:
Background: Cervical cancer is the fourth most common cancer among women globally and remains a significant public health challenge despite being largely preventable. Persistent infection with high-risk human papillomavirus (HPV), particularly HPV-16 and HPV-18, is the primary cause. Early detection through effective screening methods, such as Pap smear and colposcopy, plays a critical role in reducing cervical cancer incidence. This study evaluates the clinical outcomes of colposcopy-guided biopsy in women with abnormal Pap smear results, highlighting the importance of integrated screening approaches. Methods: This prospective observational study was conducted in the department of obstetrics and gynaecology, GS medical college and hospital, Hapur, over 15-18 months (November 2022-February 2024). A total of 150 women aged 25-65 years with abnormal Pap smear results and cervical symptoms (e.g., leukorrhea, postcoital bleeding, intermenstrual bleeding) were included. Colposcopy-guided biopsies were performed on these patients. Data were analysed using IBM SPSS version 27, applying statistical tests like the T-test and chi-square test, with p<0.05 considered significant. Descriptive statistics summarized the data, presented in charts and tables. Results: Among the 150 participants, 10.6% had abnormal Pap smear findings, and 17.3% had abnormal colposcopy findings. Squamous metaplasia (46.15%) and high-grade lesions (34.61%) were the most frequently observed abnormalities during colposcopy, while Pap smears predominantly revealed ASC-US (56.25%) and HSIL (31.25%). Postcoital and postmenopausal bleeding had the highest rates of abnormal findings. Colposcopy demonstrated greater sensitivity compared to Pap smear in detecting cervical lesions, emphasizing its importance in early diagnosis. Conclusions: Colposcopy is more sensitive than Pap smear in detecting cervical abnormalities, particularly high-grade lesions. Combining these methods enhances the accuracy and reliability of cervical cancer detection. Integrating molecular tests and visual inspection techniques into existing screening protocols could further improve outcomes. Raising public awareness about regular screening, HPV vaccination, and early detection is essential to reducing cervical cancer burden globally.
10
Jakhar, Balveer, Archana Bamniya, Radha Rastogi, Pooja Kumari, and Neeraj Choudhary. "Association of colposcopy with pap smear in evaluation of unhealthy cervix- a prospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 9 (2023): 2777–84. http://dx.doi.org/10.18203/2320-1770.ijrcog20232738.
Full textAbstract:
Background: Unhealthy cervix is a very common finding in our country due to poor genital hygiene, malnutrition and multiparity. The cervix is the commonest site for female genital cancer. Gynaecologists who work in tertiary care institutes in the developing countries to get referrals from practitioners and peripheral health centres for patients with a clinical diagnosis of an “unhealthy cervix. An “unhealthy cervix” or grossly abnormal cervix can harbour premalignant cervical lesions or invasive carcinoma. That’s why present study was planned to evaluate colposcopy role in relation to PAP smear in symptomatic patients. Methods: The present study was a prospective, analytical study. After institutional committee approval this study was conducted from January 2021 to January 2022 in department of obstetrics and gynecology at RNT Medical college, Udaipur. Total 140 women were assessed for this study. Results: Our study results based on combined cytology and colposcopy with histopathology- sensitivity =100%, specificity =87.03%, PPV=84.09%, NPV=100%, accuracy =92.30%. The result of current study supports that, PAP smear demonstrates premalignant and malignant lesions, whereas colposcopy shows the exact site for biopsy for histopathological diagnosis and for further management. Conclusions: Colposcopy and cytology are complementary to each other. Best result in early detection of pre-invasive carcinomas could be obtained by combined use of cytology, colposcopy and colposcopy guided biopsy. So, use of ‘single visit approach’ in which cytology, colposcopy and guided biopsy all are done in one setting and treated accordingly in resource poor countries will enable maximum utilization of scarce medical resources.
11
Habib, Numaya, Najmatun Jikria, Sadia Sharmin Suborna, Nasrin Aker, and AKM Ahsan Habib. "Correlation of VIA Positive Cases with Colposcopic and Histopathological Findings in Diagnosis of Precancerous Lesion of Cervix in A Tertiary Care Hospital." Scholars International Journal of Obstetrics and Gynecology 7, no. 03 (2024): 93–99. http://dx.doi.org/10.36348/sijog.2024.v07i03.003.
Full textAbstract:
Background: Cervical cancer prevention strategies are evolving by integrating new screening modalities such as human papillomavirus (HPV) DNA testing and visual inspection with acetic acid (VIA). Colposcopy, as a diagnostic tool, plays a crucial role in the management of abnormal cytology smears, especially in developed countries. However, its utilization and efficacy in resource-limited settings like Bangladesh remain underexplored. Objective: This study aimed to assess the correlation between VIA positivity and colposcopic/histopathological findings in diagnosing precancerous cervical lesions among women in Bangladesh. Method: A cross-sectional study was conducted among 200 women aged 30-60 attending the Gynecology OPD of Dhaka Medical College and Hospital. VIA positivity was determined, and all positive cases underwent colposcopic evaluation. Histopathological examination was performed for tissue samples obtained during colposcopy. Result: Among the participants, 21% were VIA-positive. Colposcopic evaluation revealed inflammation (26.2%), CIN I (38.1%), CIN II (11.1%), CIN III (9.5%), and invasive carcinoma (9.5%). Histopathology findings included inflammation (28.6%), CIN I (40.5%), CIN II (7.1%), and invasive carcinoma (16.7%). True positive and false positive cases were identified, with percentages calculated accordingly. Conclusion: Detailed colposcopic evaluation with guided biopsy is crucial for detecting pre-invasive and early cervical cancer. Integrating colposcopy into screening programs in Bangladesh could significantly reduce morbidity and mortality among young women.
12
Shaheen, Nazma, Syeda Sadia Afrin, Mohammad Rezaul Karim Ripon, Kamrun Nahar, Abu Anis Khan, and Sharmin Haque. "Assessment of cervicovaginal smear and HPV DNA co-test for cervical cancer screening: implications for diagnosis and follow-up strategies." International Journal of Research in Medical Sciences 12, no. 10 (2024): 3641–47. http://dx.doi.org/10.18203/2320-6012.ijrms20242921.
Full textAbstract:
Background: Cancer of the cervix, despite being a preventable disease, continues to be a significant public health problem in females. In recent years, much new development has taken place in the field of screening, diagnosis and management of cervical intraepithelial neoplasia. Methods: A total of 980 patients aged between 20 to 60 years were included in the study. All the patients have gone through Pap test, RT-PCR for HPV test and colposcopy biopsy. Then the sensitivity and specificity are calculated. Retrospectively selected Pap specimens with RT-PCR HPV testing results obtained from the Department of Pathology of Sheikh Fozilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladesh from July 2022 to July 2024 followed by the result is correlated with Colposcopy guided biopsy. Results: We found 250 cases of human papilloma virus RT-PCR positive, 433 cases of Pap test positive result and 399 cases of positive colposcopy biopsy result. So, The HPV test was demonstrated to be more sensitive (75%) than specific (55%) and was more sensitive than colposcopy for detecting CIN changes (75% vs. 73%). Conclusion: HPV tests showed a higher sensitivity than colposcopy, but colposcopy results presented higher specificity. Combining HPV testing and colposcopy proved to be the most efficient method for detecting CIN lesions.
13
Subedi, Kirtipal. "Correlation of colposcopy with biopsy in cases of abnormal cervical cytology." Nepal Journal of Obstetrics and Gynaecology 14, no. 1 (2019): 36–39. http://dx.doi.org/10.3126/njog.v14i1.26625.
Full textAbstract:
Aims: This study aims to find out the role of colposcopy and its correlation with cervical biopsy in detection of pre malignant cervical lesion.
 Methodology: This is hospital based prospective observational study on 60 cases with abnormal cervical cytology reports conducted in the Department of Obstetrics and Gynecology, PMWH, Thapathali, Kathmandu. Colposcopy guided biopsies were done and findings noted.
 Results: Among 60 cases enrolled in the study the most common cervical cytology finding was ASCUS, LSIL, HSIL and ASC-H present in 46.6%, 31.6%, 15% and 6.6% respectively. The colposcopy finding among these cases was normal, CIN1, CIN 2 and CIN 3 in 45%, 23.3%, 16.7% and 9% respectively. Among these cases the most common biopsy finding was normal, CIN 1, CIN 2, CIN 3 and squamous cell carcinoma in 55%, 18.3%, 8.3%, 15% and 3.3% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of colposcopy with CIN 1 as disease threshold was calculated to be 80.6%, 93.1%, 81.8% and 92.6% respectively. While evaluating the validity of colposcopy with histopathology, colposcopy seems to make an accurate diagnosis in 75% of cases, overestimating in 15% and underestimating in 8% of cases.
 Conclusions: There is a good correlation of colposcopy with histopathological diagnosis of cervical cancer.
 Keywords: colposcopy, cytology, diagnosis, premalignant
14
Suman, Kumari, Choudhary Madhuri, Buddhapriya Anisha, and Singh Neha. "A Prospective Study of Women to Establish a Link Between Pap Smear and Colposcopy Findings in Relation to Histopathological Findings." International Journal of Pharmaceutical and Clinical Research 13, no. 5 (2021): 250–57. https://doi.org/10.5281/zenodo.14217438.
Full textAbstract:
<strong>Aim:</strong> To evaluate the correlation of Pap smear and Colposcopic findings in relation to histopathological findings among sexually active women. <strong>Methods:</strong> The present prospective cross-sectional study was carried out in the department of Obstetrics and Gynaecology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India for 1 year. 100 women between 20-60 years of age with H/o abnormal vaginal discharge, pain abdomen and unhealthy cervix were included in this study. After detailed history and examination, Pap smear was taken and Colposcopic examination was done using Colposcope model 150 FC with magnification between 10X to 12.5X followed by Colposcopy guided biopsy. <strong>Results:</strong> Out of 100, 40% of cases were in 30-40 years age group followed in order by 20-30 years (25%), 40-50 years (18%) and 50-60 years (17%). Majority were (52%) multiparous (Para 3 or more) and 35% with para 2 and 13% with para 1. White discharge associated with unhealthy cervix and H/o contact bleeding was the most common clinical symptom (62%) among the cases and others were low backache (19%), pain abdomen (11%) and menstrual disorders (13%). Pap smears were stained and examined, and the findings were recorded as NILM with 67%, ASCUS (Atypical squamous cells of undermined significance) with 13%, LSIL (Low grade squamous intra epithelial lesion) with 10%, HSIL with 6% and carcinoma as 4%. Colposcopic findings were reported as benign inflammatory (RCI:0-2, 60%), low grade (RCI:3-5, 21%), high grade (RCI:6-8, 13%) and carcinoma (RCI:>8,6%). Histopathology reports showed that56% of study cases had chronic cervicitis with or without metaplasia, 19% with CIN1, 15% with CIN2 and CIN3 and 10% with carcinomas. <strong>Conclusion:</strong> The result on current study give support to the fact that Pap smear is an easy screening tool to identify premalignant and malignant lesions of cervix early in the stage of disease and Colposcopy shows the exact site for biopsy for histopathological diagnosis and for further management. Colposcopy and cytology are not competitive method, but complementary to each other.
15
Mitra, Partha Sarathi, Abhoy Chand Na, Medhatithi Barman, Debobroto Roy, Tara Shankar, and Tapan Kumar Naskar. "Screening accuracy of PAP and VIA in terms of Colposcopy guided cervical biopsy: A comparative study." Journal of Midwifery 8, no. 2 (2023): 81. http://dx.doi.org/10.25077/jom.8.2.81-93.2023.
Full textAbstract:
Introduction: Approximately 80% of cervical cancer occurs in developing countries of which India contributes about 20-30% of the global burden. WHO considers cervical cancer as a preventable disease because it can be diagnosed in its precancerous phase. Cytology and VIA for screening and colposcopy for directed biopsy jointly may achieve accuracy of approximately 90% to 99%.Methods: An observational cross sectional comparative study was performed to find accuracy of screening protocols of exfoliative cervical cell cytology and visual inspection under acetic acid in terms of the diagnostic test of Colposcopy guided biopsy on 300 symptomatic women of age 18-60 years over the period of one year.Result: Both PAP and VIA positivity increased with age, increasing parity, gynaecological symptoms. PAP and VIA positive results co related with Colposcopy directed biopsy histopatholgy reports in a statistically significant proportion.Discussion: VIA can screen out a large number of women suspected to have cervical cancer in an easy method done in OPD in naked eye and does not require any meticulous microscopic examination with a high degree of sensitivity and high false positivity but on the other hand PAP was less sensitive but more specific test when both combined with Colposcopy guided biopsy.Conclusion: The associations between distribution of women who were Pap +ve and histology +ve as well as VIA and histo +ve were statistically significant.
16
Souza, Carlos, Michelle Discacciati, Maria d'Otavianno, et al. "Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 03 (2017): 123–27. http://dx.doi.org/10.1055/s-0037-1599071.
Full textAbstract:
Objective Expectant follow-up for biopsy-proven cervical intraepithelial neoplasia (CIN) 1 is the current recommendation for the management of this lesion. Nevertheless, the performance of the biopsy guided by colposcopy might not be optimal. Therefore, this study aimed to calculate the rate of underdiagnoses of more severe lesions in women with CIN 1 diagnosis and to evaluate whether age, lesion extent and biopsy site are factors associated with diagnostic failure. Methods Eighty women with a diagnosis of CIN 1 obtained by colposcopy-guided biopsy were selected for this study. These women were herein submitted to large loop excision of the transformation zone (LLETZ). The prevalence of lesions more severe than CIN 1 was calculated, and the histological diagnoses of the LLETZ specimens were grouped into two categories: “CIN 1 or less” and “CIN 2 or worse.” Results The prevalence of lesions diagnosed as CIN 2 or worse in the LLETZ specimens was of 19% (15/80). Three women revealed CIN 3, and 1 woman revealed a sclerosing adenocarcinoma stage I-a, a rare type of malignant neoplasia of low proliferation, which was not detected by either colposcopy or previous biopsy. The underdiagnosis of CIN 2 was not associated with the women's age, lesion extension and biopsy site. Conclusions The standard methods used for the diagnosis of CIN 1 may underestimate the severity of the true lesion and, therefore, women undergoing expectant management must have an adequate follow-up.
17
Shrestha, Buddhi Kumar, Chin Bahadur Pun, Subha Shrestha, Alok Chandra Mahato, and Deeva Shrestha. "Pre-Malignant Lesions of Cervix in Female Attending a Tertiary Hospital of Nepal." Journal of College of Medical Sciences-Nepal 19, no. 2 (2023): 194–200. http://dx.doi.org/10.3126/jcmsn.v19i2.55971.
Full textAbstract:
Introduction: Cervical cancer is killing Nepali women in gross even though cervical cancer is preventable with time-tested screening strategies in Nepal. Detection of premalignant lesions of cervix is preliminary step for early treatment and to minimise the tragedy of death. The aim of this research is to corelate the Pap smear, colposcopy and guided biopsy findings with histopathology to detect premalignant lesion of cervix.Methods: A prospective observational study conducted among 145 women attending gynaecology OPD with symptoms during reproductive age 21-65 years. Collection of Pap smear was conducted by conventional method, colposcopy and guided biopsy in selected women were performed and the sample was sent to pathology department for histopathological confirmation.Results:The pre-malignant lesions in cytology were ASCUS (Atypical Squamous Cells of Undetermined Significance) 11%, ASC-H (Atypical Squamous cell- cannot exclude High Grade)1.3 %, LSIL (Low Grade Intraepithelial Lesion)28.2 %, and HSIL (High Grade Intraepithelial Lesion) 7.5 %. The colposcopy detected 54.4% atypical transformation zone. The histopathology detected Cervical Intra-epithelial Neoplasia I (CIN I) 26.1%, CIN II 11.7%, and CIN III 7.5%. The sensitivity of Pap smear and colposcopy was 83%, the specificity of Pap smear was 88%, and colposcopy was 98%.The positive predictive value(PPV)were 89% and 98 %, negative predictive value(NPV) were 81%and 83%.and accuracy was 88 % and 98% in Cytology and Colposcopy.Conclusions:Pap smear and colposcopy were effective tools to detect premalignant lesions of cervix in comparison to histopathological findings.
18
Parvin, Suraiya, Nazneen Kabir, Yeasmin Samad Lipe, Khaleda Nasreen, and KM Nurul Alam. "Correlation of pap smear and colposcopic finding of cervix with histopatholgiocal report in a group of patient attending in a tertiary hospital." Journal of Dhaka Medical College 22, no. 1 (2013): 39–44. http://dx.doi.org/10.3329/jdmc.v22i1.15604.
Full textAbstract:
Objective: To correlate Paps smear and colposcopic finding of cervix with histopathological report of abnormal area of cervix in a group of patient attending a tertiary hospital. Methods: It was a cross-sectional prospective study done in one year period from January to December 2007 in Colposcopy Clinic of Institute of Child and Maternal Health (ICMH) Hospital, Dhaka. The study carried out including fifty two female patients having clinically unhealthy cervices as in the form of hypertrophy, erosion, congestion or bleeds on touch or having positive pap smear found during P/V or P/S examination, attending gynaecology out patient department of ICMH Hospital after fulfilling all the inclusion criteria. Result: The present study showed a correlation between cervical cytology and colposcopically directed biopsy, the correlation was accurate within one grade in 39 of 51 cases (76.16%) (as cytology was not done in one case). Other studies showed cytologic accuracy (within one level of histologic finding) to about 83% and 88% cases. Conclusion: The study done here shows excellent correlation between findings of colposcopy with that of histopathology of guided biopsy. It also confirms the diagnostic value of colposcopy in the management of women with abnormal cervical cytology with squamous atypia. DOI: http://dx.doi.org/10.3329/jdmc.v22i1.15604 J Dhaka Medical College, Vol. 22, No. 1, April, 2013, Page 39-44
19
Yarlagadda, Srilakshmi, Rangarao Diddi, and Prasuna J. L. Narra. "Evaluation of women with postcoital bleeding by clinical examination, papsmear, colposcopy and histopathology of cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 6 (2018): 2184. http://dx.doi.org/10.18203/2320-1770.ijrcog20182053.
Full textAbstract:
Background: Postcoital bleeding refers to spotting or bleeding per vagina that occurs after intercourse and is not related to menstruation. Although there are multiple benign etiologies to this complaint, the most serious cause of postcoital bleeding is cervical cancer (3-5.5%). Cervical cancer is the most common and preventable genital cancer of women. It has a long premalignant phase and with an ideal screening test with good sensitivity and specificity, we can diagnose and treat premalignant cervical lesions, preventing cervical cancer. The present study is aimed to evaluate the women with postcoital bleeding by clinical examination, pap smear, colposcopy and guided biopsy to detect premalignant cervical lesions and carcinoma cervix.Methods: This was a prospective and retrospective study conducted from April, 2016 to March, 2018 for a period of 24 months in the Department of Obstetrics and Gynaecology on 100 women with postcoital bleeding at Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation (Dr. PSIMS&RF). After clinical examination, these women were subjected to pap smear, colposcopy and guided biopsy. The findings were correlated with histopathology of cervix. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of both papsmear and colposcopy were calculated.Results: Sensitivity of papsmear was 71.42%, specificity-86.20%, PPV-78.95%, NPV-80.64% and accuracy-80%. Sensitivity of colposcopy was 90.47%, specificity-89.65%, PPV-86.36%, NPV-92.85% and accuracy-90%. Conclusions: These results establish colposcopy as an effective screening test for carcinoma cervix. Histopathology of suspected cervical lesion in colposcopy remains the gold standard for definitive diagnosis.
20
Shamsunder, Saritha, Archana Mishra, Anita Kumar, and Sachin Kolte. "Automated Assessment of Digital Images of Uterine Cervix Captured Using Transvaginal Device—A Pilot Study." Diagnostics 13, no. 19 (2023): 3085. http://dx.doi.org/10.3390/diagnostics13193085.
Full textAbstract:
In low-resource settings, a point-of-care test for cervical cancer screening that can give an immediate result to guide management is urgently needed. A transvaginal digital device, “Smart Scope®” (SS), with an artificial intelligence-enabled auto-image-assessment (SS-AI) feature, was developed. In a single-arm observational study, eligible consenting women underwent a Smart Scope®-aided VIA-VILI test. Images of the cervix were captured using SS and categorized by SS-AI in four groups (green, amber, high-risk amber (HRA), red) based on risk assessment. Green and amber were classified as SS-AI negative while HRA and red were classified as SS-AI positive. The SS-AI-positive women were advised colposcopy and guided biopsy. The cervix images of SS-AI-negative cases were evaluated by an expert colposcopist (SS-M); those suspected of being positive were also recommended colposcopy and guided biopsy. Histopathology was considered a gold standard. Data on 877 SS-AI, 485 colposcopy, and 213 histopathology were available for analysis. The SS-AI showed high sensitivity (90.3%), specificity (75.3%), accuracy (84.04%), and correlation coefficient (0.670, p = 0.0) in comparison with histology at the CINI+ cutoff. In conclusion, the AI-enabled Smart Scope® test is a good alternative to the existing screening tests as it gives a real-time accurate assessment of cervical health and an opportunity for immediate triaging with visual evidence.
21
Rajkumar, Himantika Kumawat, Mamta Sharma, and Aushima Vijay. "Comparision of efficacy of visual inspection of cervix with acetic acid, Pap smear and colposcopy for prevention of cervical cancer." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 6 (2023): 1716–20. http://dx.doi.org/10.18203/2320-1770.ijrcog20231542.
Full textAbstract:
Background: Cervical cancer is second most common cancer in women globally. Overall 80% cases occurs in developing countries. An important reason for the high incidence of cervical cancer in developing countries is the lack of effective screening programs to detect precancerous conditions and treat before it progresses to invasive cancer due to severe restrictions on the availability of infrastructure, resources and funding. Aim of this study was to compare the sensitivity, specificity, PPV, and NPV of VIA, Pap smear and colposcopy with colposcopic directed biopsy (as a gold standard). Methods: This prospective analytical study was conducted on 200 women’s (age>19 years) with abnormal cervix in the Department Of Obstetrics and Gynaecology, Government Medical College Kota from 1 august 2020 to 31 July 2022 who fulfil the Inclusion criteria. All the Symptomatic patients with symptoms like vaginal discharge postcoital bleeding, itching, and other gynaecological problems along with asymptomatic patients with accidental finding of bad cervix (cervical erosion). Results: Maximum cases had common complaint of discharge per vaginum (60.55%), followed by post coital bleeding (11.5%). VIA when compared with HPR, had sensitivity 94.85% and specificity 74.76% and corresponding PPV 78% and NPV 94%. Paps smear when compared with HPR, the sensitivity was 62.89% and specificity was 89.32% and corresponding PPV 84.72% and NPV 71.88%. Colposcopy when compared with Histopathological report, the sensitivity was 70% and specificity was 91.26% and corresponding PPV 88.3% and NPV 76.4%. Conclusions: Best result for early detection of pre-invasive lesions could be with combined use of Pap smear, VIA, colposcopy and colposcopy guided biopsy rather than any individual diagnostic procedure. It will immensely reduce the morbidity and mortality.
22
Uchita, Kunihisa, Hideki Kobara, Kenji Yorita, et al. "Quality Assessment of Endoscopic Forceps Biopsy Samples under Magnifying Narrow Band Imaging for Histological Diagnosis of Cervical Intraepithelial Neoplasia: A Feasibility Study." Diagnostics 11, no. 2 (2021): 360. http://dx.doi.org/10.3390/diagnostics11020360.
Full textAbstract:
The current standard for diagnosing cervical intraepithelial neoplasia (CIN) is colposcopy followed by punch biopsy. We have developed flexible magnifying endoscopy with narrow band imaging (ME-NBI) for the diagnosis of CIN. Here, we investigated the feasibility of targeted endoscopic forceps biopsy (E-Bx) under guidance of ME-NBI for the diagnosis of CIN. We prospectively enrolled 32 consecutive patients with confirmed or suspected high-grade CIN undergoing cervical conization. Next to colposcopy, the same patients underwent ME-NBI just before conization. ME-NBI was performed, and 30 E-Bx samples were taken from lesions suspicious for high-grade CIN and 15 from non-suspicious mucosa. We recalled 82 punch biopsy (P-Bx) specimens taken from lesions suspicious for high-grade CIN under colposcopic examination before enrollment. The proportion of sufficient biopsy samples, which had an entire mucosal layer with subepithelial tissue, for the diagnosis of CIN was evaluated by both methods. Performance of targeted E-Bx for the final diagnosis of at least high-grade CIN was calculated. Seventeen P-Bx specimens were unavailable. The proportion of sufficient samples with E-Bx was 84%, which was similar to that with P-Bx (87%) (p = 0.672). The sensitivity, specificity, and accuracy of ME-NBI using E-Bx was 92%, 81%, and 88%, respectively. In conclusion, ME-NBI-guided E-Bx samples were feasible for histological diagnoses of CIN, and further investigation of its diagnostic accuracy is warranted.
23
Dorji, Namkha, Shirin Akter Begum, Tasfia Mahmud, and Mehriban Amatullah. "Evaluation of colposcopic and histopathological findings in precancerous cervical lesions." Bangladesh Medical Research Council Bulletin 46, no. 1 (2020): 48–54. http://dx.doi.org/10.3329/bmrcb.v46i1.47469.
Full textAbstract:
Background: Cervical cancer is the most frequent cancer in women worldwide. It is a preventable and curable disease with proper screening. After primary screening Colposcopy is a valuable tool in the detection and treatment of precancerous cervical lesions. Histopathology is the gold standard method of diagnosis of Precancerous lesions.
 Objective: The objective of this study was to evaluate the performance of colposcopy in the diagnosis and to make correlation between colposcopic & histopathological findings in precancerous cervical neoplasia (CIN).
 Materials and Method: It was a cross sectional study, conducted at the Colposcopy Clinic, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Study was done for a period of one year from January, 2016 to December, 2016. Sixty two married women having following complaints: positive visual inspection of cervix (VIA + ve) with 3-5% Acetic acid, postcoital bleeding, postmenopausal bleeding, and intermenstrual bleeding were recruited for the study. Written informed consent was obtained from the participants. The questionnaire was pretested, corrected and finalized. The data collection was done using the interviewer administered questionnaire. Colposcopic examination of cervix was done in 62 participants. Colposcopy guided punch biopsy/Loop electrosurgical excision procedure (LEEP) from acetowhite area was taken in cases of VIA +ve women and random four quadrants (1, 5, 7 & 11 O’ clock position) cervical biopsy in cases of VIA – ve women having other indications. Histopathological examinations of specimens were done in the Department of Pathology, BSMMU. Descriptive analysis, chi-square test (X2) and Fisher’s exact test were performed. P value<0.05 was taken as statistically significant.
 Result: The mean age of the study population was 36.8±11.9 years ranging from 20 to72 years. Out of 62 participants, 40.3% (n=25) had VIA positive, 41.9% (n=26) had postcoital bleeding among which 24 was VIA positive and 2 was VIA negative, 8.1% (n=5) had intermenstrual bleeding with positive VIA and 9.7% (n=6) post-menopausal bleeding among which 4 was VIA positive and 2 was VIA negative. Among total 62 participants
 Sensitivity of colposcopy to diagnose histopathologically confirmed CIN I was 82.6%, CIN II was 25% and CIN III was also 25%. The specificity to diagnose CIN I was 42.4%, CIN II was 91.4% and CIN III was 93.1%. PPV of colposcopy to diagnose histologically confirmed CIN I was 55.8%, CIN II was 16.7% and CIN III was 20%. The NPV to diagnose CIN I was 73.7%, CIN II was 94.6% and CIN III was 94.7%. The colposcopic accuracy to diagnose CIN I was 61.3%, CIN II was 87.1% and CIN III was 90.3%. There was statistically significant (P value <0.05) correlation for colposcopic diagnosis of histopathologically confirmed CIN I,CIN II and III.
 Conclusion: The accuracy of colposcopy to diagnose histopathologically confirmed precancerous cervical lesions was quite high. Patients presenting with postcoital bleeding and postmenopausal bleeding should have colposcopy and biopsies even if the screening test result normal. Moreover colposcopy has high sensitivity, so we can easily adopt the see and treat method to reduce the dropout.
 Bangladesh Med Res Counc Bull 2020; 46(1): 48-54
24
Venkatesh, Meenakshi, and Ushadevi . "Evaluation of unhealthy cervix by Pap smear and colposcopy guided biopsy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 6 (2020): 2663. http://dx.doi.org/10.18203/2320-1770.ijrcog20202372.
Full textAbstract:
Cancer of cervix ranks as the third common malignancy in females worldwide. In developing countries like India, carcinoma cervix is the second commonest malignancy affecting females. India accounts for 18% of the global burden of carcinoma cervix. To address the above problem a literature review was done using search engines like PubMed, Google scholar etc to evaluate the unhealthy cervix by comparison of Pap smear and colposcopy guided biopsy.
25
Venkatesh, Meenakshi, and Ushadevi . "A comparative study of Pap smear and colposcopy guided biopsy in the evaluation of unhealthy cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 6 (2020): 2305. http://dx.doi.org/10.18203/2320-1770.ijrcog20202301.
Full textAbstract:
Background: Cancer of cervix ranks as the third common malignancy in females worldwide. In developing countries like India, carcinoma cervix is the second commonest malignancy affecting females. In India, every year 1,26,000 new cases are identified and 67,477 deaths occur due to cervical carcinoma. Cervical carcinoma affects women of age 15-44 years and disease peaks at 55-66 years. On average, Indian women have a 2.5% risk of developing carcinoma cervix. It was estimated worldwide that every 5th woman, who suffer from cervical cancer belongs to India.Methods: A comparative study which included 110 married women of age 20 to 65 years. Women who presented with white discharge, lower abdominal pain, post coital bleeding and post-menopausal bleeding were subjected to Pap smear and colposcopy guided biopsy.Results: A total 53.6% women had inflammatory smear, followed by 34.5% women with normal Pap smear, 0.1% women had bacterial vaginosis, 6.4% women had LSIL and 4.5% women had HSIL. Authors found that 63.6% women had chronic cervicitis. 15.4% had chronic endo papillary cervicitis, 13.6% had CIN 1, 5.4% women had CIN 2 and 1.8% women had squamous cell carcinoma. Association of Pap smear with histopathology is statistically significant (p value <0.001).Conclusions: Pap smear can be used as screening test for detecting premalignant lesions of cervix. Colposcopy guided cervix biopsy has got better specificity than Pap smear, so all symptomatic women should be subjected to colposcopy guided cervix biopsy to detect carcinoma at early stage.
26
Kim, Seongmin, Hwajung Lee, Sanghoon Lee, Jae-Yun Song, Jae-Kwan Lee, and Nak-Woo Lee. "Role of Artificial Intelligence Interpretation of Colposcopic Images in Cervical Cancer Screening." Healthcare 10, no. 3 (2022): 468. http://dx.doi.org/10.3390/healthcare10030468.
Full textAbstract:
The accuracy of colposcopic diagnosis depends on the skill and proficiency of physicians. This study evaluated the feasibility of interpreting colposcopic images with the assistance of artificial intelligence (AI) for the diagnosis of high-grade cervical intraepithelial lesions. This study included female patients who underwent colposcopy-guided biopsy in 2020 at two institutions in the Republic of Korea. Two experienced colposcopists reviewed all images separately. The Cerviray AI® system (AIDOT, Seoul, Korea) was used to interpret the cervical images. AI demonstrated improved sensitivity with comparable specificity and positive predictive value when compared with the colposcopic impressions of each clinician. The areas under the curve were greater with combined impressions (both AI and that of the two colposcopists) of high-grade lesions, when compared with the individual impressions of each colposcopist. This study highlights the feasibility of the application of an AI system in cervical cancer screening. AI interpretation can be utilized as an assisting tool in combination with human colposcopic evaluation of exocervix.
27
Shrestha, Junu, Dilasma Gharti Magar, and Chandani Pandey. "Cervical Intraepithelial Lesions in Women with Persistent Inflammatory Smear on Pap Smear: A Descriptive Cross-sectional Study." Journal of Nepal Medical Association 59, no. 241 (2021): 848–52. http://dx.doi.org/10.31729/jnma.7011.
Full textAbstract:
Introduction: Persistent inflammatory smear is a benign finding on pap test but is associated with premalignant lesion of the cervix. Further evaluation is therefore necessary. This study was done to determine the prevalence of cervical intraepithelial lesions in women with persistent inflammatory smear. Methods: This is descriptive observational study conducted in Department of Obstetrics and Gynaecology of tertiary care centre of Nepal from 15th May 2020 to 14th May 2021 after obtaining ethical clearance from Institutional Review Board (Reference no MEMG/IRC/338/GA). Women with two consecutive pap smear reports showing inflammatory findings were enrolled. Colposcopy was performed and Modified Reid’s colposcopic index was used to grade the lesions. Colposcopic guided biopsy was taken and tissue sent for histopathology for abnormal colposcopic lesions. Data analysis was done using Statistical Package for Social Sciences version 21 and frequency and percentages were used to present data. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Among 115 women, 57 (49.5%) at 95% Confidence Interval (40.37-58.63) had Cervical Intraepithelial lesions. Among them 48 (41.7%) had low grade intraepithelial lesions and 9 (7.8%) had high grade lesions on colposcopy. Conclusions: The prevalence of cervical intraepithelial lesions in women with persistent inflammatory smear on pap was higher in our study compared to other studies.
28
Marimuthu, Kavitha, and Malarvizhi Loganathan. "Comparing the efficacy of visual inspection with acetic acid and lugol’s iodine as a screening tool for detecting cervical lesions in asymptomatic women of reproductive age group with colposcopy and biopsy in a tertiary care hospital." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 5 (2017): 1766. http://dx.doi.org/10.18203/2320-1770.ijrcog20171528.
Full textAbstract:
Background: A quarter of global burden of carcinoma cervix is experienced in India, where about 1, 26,000 new cases and 71,000 deaths attribute to cervical cancer are estimated to occur each year. Cervical cancer constitutes 15-55% of all female cancer and value of age standardized incidence ranges from 17.2 to 55 per 1 lakh women in different region in India with 5-year survival rate of less than 40% as most are detected at advanced stage. The objective of present study was to identify the incidence of cervical lesions in sexually active asymptomatic women.Methods: This prospective study conducted in a tertiary care hospital for 1 year. This study comprises study subject of 734 women who were attending general and gynecology OPD. All 734 patients were subjected to visual inspection and magnification (VIA/VILI), colposcopy and biopsy was done in the positive patients.Results: Of 734 cases studied, colposcopy was positive in 97 (13.1%). Among 97 cases who were colposcopy positive, VIA/VILI was positive in 90 cases. Colposcopy guided biopsy was positive in 97 cases. The sensitivity of VIA/VILI in detecting preinvasive lesions was 91.84% and specificity was 100% when compared with colposcopy which has sensitivity 98.98% and specificity 100%.Conclusions: There is an enormous increase in the incidence of cancer cervix in geometric proportion. This can be controlled only with the introduction of mass screening programme by magnavision in a coordinated way in low resource settings.
29
Begum, Mst Moonmoon, Ferdousi Sultana, and Hasina Ferdousy. "Cervical Cancer Screening Program in Rangpur Medical College Hospital: 11 Years Experience." Bangladesh Journal of Obstetrics & Gynaecology 33, no. 1 (2019): 11–16. http://dx.doi.org/10.3329/bjog.v33i1.43268.
Full textAbstract:
Background: Prevention of cervical cancer is the easiest with regular screening tests and follow up. CIN is a pre-malignant condition, detection of which is possible by VIA and colposcopy.
 Objective: To identify the performance of Cervical Cancer Screening Program in Rangpur Medical College Hospital through 11 Years.
 Methods and materials: Apparently healthy, married or sexually active women (>10 years) and women aged >30 years attending Gynae OPD were included in this study. After counseling and informed consent a speculum examination was performed for direct visualization of cervix to identify the squamo-columner junction. Freshly prepared 5% acetic acid was applied to the cervix for one minute. All the VIA positive women were further evaluated by colposcopy. Women with negative VIA were advised for 3 yearly VIA test. Suspected CIN cases were evaluated by colposcopy guided punch biopsy or LEEP biopsy and histopathology.
 Results: VIA screening was provided for 11,792 women from August 2005 to August 2016 and 932 (7.9%) were positive VIA. From November 2007 to August 2016, total women underwent colposcopy were 1548. Among them 632 (40.8%) were normal, out of abnormal cases 730 (80.3%) were CIN-1, 147 (16.1%) were CIN-2, 14 (1.5%) were CIN-3, 17 (1.8%) were invasive and 8 (0.5%) were unsatisfactory. From November 2007 to August 2016 punch biopsy was taken in 384 women and total 568 women were treated by LEEP.
 Conclusion: In a low resource setting like Bangladesh VIA and colposcopy can detect 80% pre-invasive cervical lesion and may be one of the most important tool to prevent cervical cancer and its mortality.
 Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 11-16
30
Samad, Khurshida, AJE Nahar Rahman, Imtiaz Ahmed, Abu Sayeed Mohammad, and Md Sirajul Islam. "Histopathological Diagnosis of Colposcopically Negative Cases for CIN." Journal of National Institute of Neurosciences Bangladesh 6, no. 1 (2020): 29–32. http://dx.doi.org/10.3329/jninb.v6i1.48026.
Full textAbstract:
Background: Colposcopy is a good diagnostic tools for the detection of abnormalities cervix of the uterus.
 Objective: The purpose of the present study was to see the histological diagnosis of colposcopically negative cases for CIN among VIA positive women.
 Methodology: This cross sectional study was conducted in the Department Of Pathology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July 2007 to June 2008 for one (01) year. Patients who are colposcopically negative but clinically suspicious for cervical neoplasia were included in this study. The cervix was examined on naked eye by Cusco’s speculum to see whether it was healthy or not. Then it was examined by the colposcope after applying 3 to 5% acetic acid and colposcopic findings were collected. VIA positive cases were underwent colposcopy guided LEEP biopsy.
 Result: A total of 63 patients of different age group were recruited for this study. The age of 63 patients ranged from 20 years to 65 years with an average age of 34.6±9.59 years. Among 63 VIA positive patients, 54 cases were colposcopically positive for cervical intraepithelial neoplasia and carcinoma in situ, remaining 9 patients were colposcopically negative. Histological examination was also performed in nine patients who were colposcopically negative but clinically suspicious for malignancy or precancerous lesion. Of these nine cases, eight cases (89%) were diagnosed as chronic cervicitis, one case (11.0%) as CIN-I and none as CIN-II and CIN- III.
 Conclusion: In conclusion majority of the colposcopically negative VIA positive cases are the patients of chronic cervicitis.
 Journal of National Institute of Neurosciences Bangladesh, 2020;6(1): 29-32
31
Aymen, Laaliaoui. "Conisation and cervical dysplasia concordance between cytology, Colposcopy and histology." Journal of Cancer Research and Cellular Therapeutics 8, no. 4 (2024): 01–05. http://dx.doi.org/10.31579/2640-1053/199.
Full textAbstract:
Conization is a crucial component of the diagnosis and, more importantly, the management of neoplasia found by cytology. We attempted to incorporate conization into the diagnosis and treatment toolkit for precancerous conditions of the uterine cervix in light of a retrospective series of 15 cases. It is required for the diagnosis of microinfestation and enhances the diagnostic yield offered by cytology and biopsy by itself or when guided by colposcopy. In 82% of the cases in our series, the FCU was in agreement with conization, but in 12% of the cases, it overstated the lesion. In 67% of cases, a biopsy resulted in an appropriate diagnosis. In 20% of cases, it overstated the lesions, and in 12% of cases, it underestimated them.
32
Martí, Cristina, Lorena Marimón, Ariel Glickman, et al. "Usefulness of E7 mRNA in HPV16-Positive Women to Predict the Risk of Progression to HSIL/CIN2+." Diagnostics 11, no. 9 (2021): 1634. http://dx.doi.org/10.3390/diagnostics11091634.
Full textAbstract:
Objective: To evaluate whether E7 mRNA can predict the risk of progression in women with HPV16 infection. Design: A prospective observational study. Setting: A tertiary university hospital. Population: A cohort of 139 women referred to colposcopy for an abnormal screening result fulfilling the following inclusion criteria: (1) a positive test result confirming HPV16 infection; (2) a biopsy sample with a histological diagnosis of an absence of lesion or low-grade SIL/CIN grade1 (LSIL/CIN1); (3) no previous HPV vaccination; (4) no pregnancy; and (5) no previous cervical treatments; and (6) no immunosuppression. Methods: At the first visit, all women underwent a cervical sample for liquid-based cytology, HPV testing and genotyping, and HPV16 E7 mRNA analysis and a colposcopy with at least one colposcopy-guided biopsy. Follow-up visits were scheduled every six months. In each control, a liquid-based Pap smear, HPV testing, as well as a colposcopy examination with biopsy if necessary were performed. Main outcome measures: Histological diagnosis of HSIL/CIN2+ at any time during follow-up. Results: E7 mRNA expression was positive in 55/127 (43.3%) women included in the study and seven (12.7%) progressed to HSIL/CIN2+. In contrast, only 1/72 (1.4%) women with no HPV16 E7 mRNA expression progressed (p = 0.027). HPV16 E7 mRNA expression was associated with a 10-fold increased risk of progression (HR 10.0; 95% CI 1.2–81.4). Conclusions: HPV16 E7 mRNA could be useful for risk stratification of women with HPV16 infection in whom a HSIL/CIN2+ has been ruled out. Funding: Instituto de Salud Carlos III (ICSIII)-Fondo de Investigación Sanitaria and ERDF ‘One Way to Europe’ (PI17/00772).
33
Paltacı, Şeyma İlayda, Sudaba Garibova, Rıza Dur, and Mine Kanat Pektaş. "DIAGNOSTIC ACCURACY OF ENDOMETRIAL SAMPLING AND COLPOSCOPY GUIDED CERVICAL BIOPSY IN WOMEN UNDERGOING HYSTERECTOMY: A SINGLE-CENTER EXPERIENCE." Kocatepe Tıp Dergisi 26, no. 2 (2025): 122–27. https://doi.org/10.18229/kocatepetip.1522212.
Full textAbstract:
OBJECTIVE: This study aims to compare the results of the preoperatively obtained endometrial and cervical biopsies to the histopathological characteristics of the related hysterectomy specimens and, thus in vestigate their consistency. MATERIAL AND METHODS: This is a retrospective review of 390 hysterectomies performed for both benign and malignant indications as verified by cervical and endometrial biopsies at the study center between 1 January 2017 and 1 January 2023. RESULTS: Seventy-four hysterectomies (19.0%) had preoperative cervical biopsy results, while 316 had preoperative endometrial biopsy results (81.0%). Only 55.6% agreement (κ=0.011) and no significant correlation between endometrial biopsy results and related hysterectomy specimens for benign lesions (χ2=4.500, p=0.343). There were 85.1% agreement (κ=0.462) and a significant correlation between cervical biopsy results and related hysterectomy specimens for pre-invasive and malignant lesions (χ2=106.349, p=0.001). Endometrial biopsy results presenting polyps had the lowest diagnostic accuracy of 59.3% and endometrial cancer was identified in 52.2% of the patients whose biopsy results revealed complex hyperplasia with atypia. CONCLUSIONS: The relatively lower diagnostic accuracy of endometrial biopsy suggests that it is not required for definitive diagnosis in patients who are scheduled to have a hysterectomy for benign indications. The relatively higher rate of complex atypical hyperplasia and endometrial cancer co-existence also indicates that hysteroscopy can be performed to visualize the uterine cavity before a hysterectomy is planned for patients with biopsy-based hyperplasia. The relatively higher concordance rate between cervical biopsy results and related hysterectomy specimens supports the significance and validity of colposcopy in the management of pre-invasive and malignant lesions of the cervix.
34
Mohan, Priyanka, Lakshmidevi M., and Shreedhar Venkatesh. "Comparative study of papanicolaou smear and colposcopy in the evaluation of cervical lesions." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 6 (2019): 2400. http://dx.doi.org/10.18203/2320-1770.ijrcog20192438.
Full textAbstract:
Background: Cervical cancer is the third most common type of cancer among females. Study aims to critically evaluate the sensitivity and specificity of colposcopy versus papanicolaou (Pap) smear in the early detection of dysplasias. Its secondary objective to correlate the findings in the evaluation of unhealthy cervix by cytology, colposcopy and colposcopy guided biopsy.Methods: This was a tertiary care teaching hospital based, prospective, cross sectional study done in Department of Obstetrics and Gynaecology, at Vydehi Institute of Medical Sciences and Research Centre, Bangalore, conducted on 200 women attending Gynaecology OPD.Results: PAP smear was taken for all 200 patients. 73% of smear was found to be normal, 11% showed inflammatory atypia, 9% showed low grade squamous intraepithelial lesion (LSIL), 3.5% showed atypical squamous cells of undetermined significance (ASCUS) and 3.5% showed High Grade Squamous Intraepithelial Lesion (HSIL). Among the 200 cases studied, 38% (76/200) were diagnosed as colposcopically abnormal. Among the abnormal cases, AW areas were diagnosed in 4%. Punctate pattern of vessels was seen in 5% of women. Normal findings was present in 62%, Erosion cervix in 6%, inflammatory changes were seen in 6% and polyps were diagnosed in 7.5%, leucoplakia was found in 2% and unsatisfactory colposcopy finding was seen in 4% and underwent endocervical curettage. 32 cases out of 200 women were positive on Pap smear. 66 out of 200 women were positive on Biopsy. Pap smear was positive in 22 out of 66 biopsy proven positive cases.Conclusions: The commonest presenting complaint was vaginal discharge (182/200; 91% of the patients. the PAP smear is found to have sensitivity of 33.33% and specificity of 92.54%. colposcopy is found to have sensitivity of 81.82% and specificity of 82.84%.
35
Noor, L., MA Gafur, M. Ahmed, and I. Ara. "Prevention of carcinoma cervix in Bangladesh perspective." Mediscope 3, no. 1 (2016): 33–39. http://dx.doi.org/10.3329/mediscope.v3i1.29734.
Full textAbstract:
Carcinoma cervix is a preventable disease. Etiological factor is known that is human papilloma virus (HPV). Two types of vaccines are available. Cervix is easily accessible allowing screening tests possible. Screening is simple and available. The disease has long premalignant phase that can be detected by screening. Although Pap smear is the gold standard method of screening, visual inspection with acetic acid (VIA) particularly single-visit approach, can be an appropriate alternative in Bangladesh considering our available health care facilities. If abnormal screening results (Pap test,VIA, HPV test), colposcopy and guided biopsy can be taken. Colposcopy can detect cervical intraepithelial neoplasia and early invasive carcinoma. Treatment in pre-invasive and early invasive carcinoma is found to be curative.Mediscope Vol. 3, No. 1: January 2016, Pages 33-39
36
Lokhande, Supriya, Neethika Raghuwanshi, Madhuri Dhakne, and Sushma Deshmukh. "Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient." Asian Journal of Medical Sciences 13, no. 4 (2022): 98–105. http://dx.doi.org/10.3126/ajms.v13i4.41268.
Full textAbstract:
Background: Carcinoma Cervix is one of the common malignant pathology causing considerable morbidity and mortality in women. One of the important aspects of management of carcinoma cervix is its early detection and appropriate management since delay in the diagnosis can have catastrophic consequences. Unfortunately in developing countries in many cases, diagnosis is delayed due to non-availability of facilities at rural areas. To overcome this screening methods such as Visual Inspection with Acetic Acid (VIA) and PAP smear can be done in high-risk patients and in selected cases cervical biopsy can be done. Aims and Objectives: (1) To compare VIA and PAP smear in relation to colposcopy as a screening method for premalignant lesions of cervix. (2) To study the efficacy of VIA as a primary screening test for detection of premalignant lesions of cervical cancer. Materials and Methods: This was a prospective analytical study in which 100 women with unhealthy cervix attending obstetrics and gynecology out patient department who were willing to participate and gave written informed consent were enrolled in the study on the basis of a predefined inclusion and exclusion criteria. VIA was done. Pap smear was taken and slides were stained with modified Papanicolaou staining method and examined under light microscope. we compared the efficacy of VIA and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient, and the results were confirmed with the help of colposcopy examination and its histopathological correlation with guided biopsy. Results: Mean age of the study population was found to be 40.94 years. When VIA, PAP Smear, and colposcopy were compared highest sensitivity was seen in VIA whereas colposcopy showed highest accuracy (82%). PAP was found to have a higher specificity (84.62%) as compared to VIA or colposcopy. Highest positive predictive value and negative predictive value was seen in PAP smear (78.95%) and colposcopy (86.96%). Conclusion: VIA is an easy to perform and highly sensitive test for diagnosis of carcinoma cervix however it has got a poor specificity. Colposcopy was found to be a better diagnostic test as it was both more sensitive as well as specific to diagnose premalignant lesions.
37
Nur, Dr Ayesha Nigar, Prof Dr Meherun Nessa, and Dr Ferdousi Begum. "Colposcopy Assessment of Persistent Inflammatory Changes in Cervical Cytology." East African Scholars Journal of Medical Sciences 7, no. 05 (2024): 220–24. http://dx.doi.org/10.36349/easms.2024.v07i05.009.
Full textAbstract:
Introduction: It has been reported that inflammation on Pap smear is quite common. Chronic inflammation, whether specific or nonspecific, has been linked to cancer development and is considered one of the factors responsible for carcinogenesis. Women who have persistent inflammation on Pap smear should undergo further evaluation and treatment. Objective: This research aims to study the effectiveness of colposcopy in terms of assessing persistent inflammatory changes in cervical cytology e.g., Pap smear. Methods: Between January 2021 and January 2024, this prospective study was carried out in the Department of Obstetrics and Gynecology at Holy Family Red Crescent Medical College Hospital in Dhaka, Bangladesh. The study involved screening 320 women with Pap smear tests. Women who received an inflammatory Pap smear report, aged between 20 years and 65 years, were included in the study. Both partners were treated and advised to use barrier contraception for the same duration. These women were asked to come back after six weeks for Pap smear and VIA follow-up tests. Patients with persistent inflammation, even if VIA negative, were then referred for colposcopy and guided biopsy. Results: Out of a group of 320 women, 234 (73.13%) had an initial Pap smear report suggesting inflammation. Out of all the women who were examined, 21% had normal colposcopic findings while 79% had abnormal findings. After a histopathological examination (HPE), it was found that 69% of women had cervical intraepithelial neoplasia (CIN) 1, 23% had CIN II, 6% had CIN III, and 3% had SCC. Additionally, 25% of women tested positive for HPV DNA and 75% of women tested negative for HPV DNA. Conclusion: It is important to repeat an inflammatory smear test because persistent inflammation can cause dysplasia. Patients with persistent inflammatory Pap smears despite undergoing treatment show changes on Colposcopic directed biopsies. In addition to a Pap smear, VIA (Visual Inspection with Acetic Acid) ......
38
Aneeta, Kumari, and Sinha Puja. "A Study Assessing Association between Pap smear and Cervical Biopsy in A Woman with Unhealthy Cervix." International Journal of Current Pharmaceutical Review and Research 16, no. 3 (2024): 231–35. https://doi.org/10.5281/zenodo.12785231.
Full textAbstract:
Aim: The aim of the present study was to assess the Pap Smear and Cervical Biopsy in a woman with unhealthycervix attending tertiary care centre.Material & methods: This study included 200 married women aged 20-65 years attending Department ofObstetrics and Gynaecology, SKMCH, Muzaffarpur, Bihar, India over the duration of 18 months.Results: In this study, 42% women belong to age group 31-40 years. 31% women belong to 41-50 years of age.16% women belong to 20-30 years of age, 11% women belong to 51-60 years of age. In this study 40% womenwere para 3, 30% women were para 4, 16% women were para 5, 5% women were para 2, 3% women were para6 and 2% women were primipara. In this study population, white discharge was the most common chief complaint(49%), followed by lower abdominal pain in 24%, low back ache in 12%, postcoital bleeding in 9% andpostmenopausal bleeding seen in 6%. In this study, association of Pap smear with histopathology was found to bestatistically significant (p value <0.001).Conclusion: PAP smear can be used as screening test for detecting premalignant lesions of cervix. Cervix biopsyhas got better specificity than Pap smear, so all symptomatic women should be subjected to cervix biopsy to detectcarcinoma at early stage.
39
Sweta, Kumari, Shilpa Simpi, and Singh Seema. "Assessment with Pap Smear and Cervical Biopsy in a Woman with Unhealthy Cervix Attending Tertiary Care Hospital." International Journal of Current Pharmaceutical Review and Research 15, no. 11 (2023): 719–23. https://doi.org/10.5281/zenodo.11613410.
Full textAbstract:
AbstractAim: The aim of the present study was to assess the Pap Smear and Cervical Biopsy in a woman with unhealthycervix attending tertiary care centre.Material & Methods: This study included 100 married women aged 20-65 years attending Department ofObstetrics And Gynaecology, over the duration of 18 months.Results: In this study, 43% women belong to age group 31-40 years. 30% women belong to 41-50 years of age.15% women belong to 20-30 years of age, 12% women belong to 51-60 years of age and 2.7% women are morethan 60 years of age. In this study 39% women were para 3, 31% women were para 4, 15% women were para 5,6% women were para 2, 4% women were para 6 and 2% women were primipara. In this study population, whitedischarge was the most common chief complaint (48%), followed by lower abdominal pain in 25%, low backache in 11%, postcoital bleeding in 10% and postmenopausal bleeding seen in 6%. In this study, association ofPap smear with histopathology was found to be statistically significant (p value <0.001).Conclusion: PAP smear can be used as screening test for detecting premalignant lesions of cervix. Cervix biopsyhas got better specificity than Pap smear, so all symptomatic women should be subjected to cervix biopsy to detectcarcinoma at early stage.
40
Aymen, Laaliaoui, Agoug Zine El Abiddine, Tossi Sara, et al. "CONISATION ET DYSPLASIES CERVICALES CONCORDANCE ENTRE CYTOLOGIE, COLPOSCOPIE ET HISTOLOGIE." International Journal of Advanced Research 12, no. 07 (2024): 697–702. http://dx.doi.org/10.21474/ijar01/19102.
Full textAbstract:
Conization is a crucial component of the diagnosis and, more importantly, the management of neoplasia found by cytology. We attempted to incorporate conization in the diagnostic and treatment toolkit for precancerous conditions of the uterine cervix in light of a retrospective series of 15 cases. It is required for the diagnosis of microinvasion and enhances the diagnostic yield offered by cytology and biopsy by itself or when guided by colposcopy. In 82% of the cases in our series, the FCU was in agreement with conization, but in 12% of the cases, it overstated the lesion. In 67% of cases, a biopsy resulted in an appropriate diagnosis. In 20% of cases, it overstated the lesions, and in 12% of cases, it underestimated them.
41
Archana, Agarwal, and Agarwal Ritika. "Comparative Evaluation of Pap Smear and Colposcopy for Cervical Cancer Screening: A Tertiary Care Study in North India." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 956–64. https://doi.org/10.5281/zenodo.11279591.
Full textAbstract:
<strong>Background: </strong>Cervical cancer is a major global health challenge, particularly in developing regions. Early detection through effective screening is essential for reducing its prevalence and mortality. The Pap smear test, a widely used screening tool, has inherent limitations such as sensitivity and specificity concerns. Colposcopy, which offers a closer examination and guided biopsy, complements Pap smears. However, its accessibility and operator dependence vary. Histopathological examination, the gold standard, delivers detailed information but is invasive and may involve delays in results. Evaluating these screening methods is crucial for optimizing cervical cancer screening strategies, especially in diverse healthcare settings. This study aims to provide a comprehensive assessment of Pap smear cytology and colposcopy compared to cervical biopsy/histopathology as the reference standard for cervical carcinoma and precancerous lesions detection. <strong>Methods: </strong>This cross-sectional comparative study was conducted over two years from July 2021 to June 2023 at a North Indian tertiary care hospital after obtaining ethical approval from the Institutional Review Board, adhering to the Declaration of Helsinki. The study included 143 women aged 18-55 years, focusing on high-risk clinical presentations related to cervical abnormalities. Data collected covered demographics, clinical history, and physical examinations. Statistical analysis, including sensitivity, and specificity, was performed using SPSS version 20.0 with a significance threshold of p < 0.05. <strong>Results: </strong>The study included 143 women aged 18-55 years with high-risk clinical indications. Pap smear cytology demonstrated an overall positivity rate of 58.04%, with ASCUS (15.38%) and LSIL (19.58%) being the most common abnormalities. Colposcopy showed a higher positivity rate of 70.63%, with abnormal findings including inflammation (9.79%) and LSIL (14.00%). Histopathological examination confirmed cervical abnormalities in 69.23% of cases, with LSIL (16.78%) and HSIL (13.29%) being the most frequent. Sensitivity and specificity for Pap smear were 56.52% and 71.62%, respectively. For colposcopy, sensitivity and specificity were 98.55% and 82.43%, respectively. <strong>Conclusion: </strong>A combination of both techniques could enhance early detection and intervention, thereby reducing the burden of cervical cancer in this region. As cervical cancer remains a significant public health issue in this region, the results of this study may contribute to the development of more effective cervical cancer screening programs and policies.
42
Xie, H., T. Hu, L. Li, et al. "10P Human papillomavirus integration testing and high-grade cytology improve diagnostic performance of colposcopy-guided biopsy." ESMO Open 9 (June 2024): 103510. http://dx.doi.org/10.1016/j.esmoop.2024.103510.
Full text
43
Stabile, Sueli Aparecida Batista, Dilson Henrique Ramos Evangelista, Valdely Helena Talamonte, Umberto Gazi Lippi, and Reginaldo Guedes Coelho Lopes. "Comparative study of the results from conventional cervico-vaginal oncotic cytology and liquid-based cytology." Einstein (São Paulo) 10, no. 4 (2012): 466–72. http://dx.doi.org/10.1590/s1679-45082012000400013.
Full textAbstract:
OBJECTIVE: To compare two oncotic cervical cytology techniques, the conventional and the liquid-based cytology, in low risk patients for uterine cervical cancer. METHODS: Comparative prospective study with 100 patients who came to their annual gynecological exam, and were submitted simultaneously to both techniques. We used the McNemar test, with a significance level of p<0.05 to compare the results obtained related to adequacy of the smear quality, descriptive diagnosis prevalence, guided biopsy confirmation and histology. RESULTS: Adequacy of the smear was similar for both methods. The quality with squamocolumnar junction in 93% of conventional cytology and in 84% of the liquid-based cytology had statistical significance. As for the diagnosis of atypical cells they were detected in 3% of conventional cytology and in 10% of liquidbased cytology (p=0.06). Atypical squamous cells of undetermined significance were the most prevalent abnormality. The liquid-based cytology performance was better when compared with colposcopy (guided biopsy), presenting sensitivity of 66.7% and specificity of 100%. There was no cytological and histological concordance for the conventional cytology. CONCLUSIONS: Liquid-based cytology had a better performance to diagnose atypical cells and the cytohistological concordance was higher than in the conventional cytology.
44
Kapur, Dhriti, Amrita Gaurav, Kavita Khoiwal, et al. "“See and Treat” an Advocated Approach for Precancerous Lesions of the Cervix- A North Indian Referral Center Based Randomized Control Trial." Asian Pacific Journal of Cancer Biology 7, no. 3 (2022): 225–31. http://dx.doi.org/10.31557/apjcb.2022.7.3.225-231.
Full textAbstract:
Objective: To establish the comparability of two step approach of See and treat with the conventional three step approach In management of Precancerous lesions of the cervix. Methods: A Randomised controlled Trial was conducted in AIIMS Rishikesh over a period of one year (2020-2021). All women presenting to OPD in age group 25-60 years were screened with PAP smear and per speculum examination, and women with Abnormal PAP smear or clinically unhealthy cervix were subjected to colposcopy. Reid and Swede scores were calculated and colposcopy guided biopsy taken. Women with CIN2/3 on either of the colposcopy scores were randomized to two or three step approach. Women falling into two step approach (group A) underwent LEEP in the same sitting while the latter group (group B) was told to follow up with histopathology reports for further management.The final histopathological diagnosis and LEEP results were compared. Results: Overtreatment rates were 22% in see and treat approach, distributed as 3.6% in HSIL + ASC_H group and 33 % in LSIL patients. None were lost to treatment in this group. 39 out of 50 women in Group B needed definitive treatment after their biopsy results and 48% of them were lost to follow up. 72% were adequately treated in group A while only 22 % could be adequately treated in Group B. Conclusion: It can thus be safely concluded that despite the risk of overtreatment, a two step approach should be considered for preventive management, especially considering the rate of loss to follow up in three step approach. This study thus advocates the use of See and Treat protocol, especially in the high-grade cytology lesions. IN low risk cases too, the study proposes that see and treat protocol can be used, albeit with good clinical judgement. Offering opportunities to reduce suffering associated with the eminently preventable cervical cancer is an ethical imperative and the SEE and TREAT approach is an attempt in that early preventive direction.
45
Adad, Sheila Jorge, Maria Azniv Hazarabedian Souza, Renata Margarida Etchebehere, João Carlos Saldanha, Vera Alice Aguiar Falco, and Eddie Fernando Cândido Murta. "Cyto-histological correlation of 219 patients submitted to surgical treatment due to diagnosis of cervical intraepithelial neoplasia." Sao Paulo Medical Journal 117, no. 2 (1999): 81–84. http://dx.doi.org/10.1590/s1516-31801999000200006.
Full textAbstract:
CONTEXT: Cervical cytology continues to be the most appropriate method for investigating cervical neoplasia and its precursors. Greater diagnostic acuity is obtained by combining cytology, colposcopy and guided biopsy methods. OBJECTIVE: To analyze the diagnostic acuity of cyto- and histopathological exams and causes of diagnostic error. DESIGN: Retrospective study. SETTING: A public tertiary referral center. SAMPLE: Reports on 219 patients submitted to cone biopsy and/or hysterectomy due to diagnosis of cervical intraepithelial neoplasia (CIN) in the period between January 1982 and March 1997 were reviewed, comparing. MAIN MEASUREMENTS: cytological and histological exams (guided biopsy and surgically-removed tissue). In cases of discordance, the cyto- and histological preparations were reviewed to try to evaluate the causes of errors. RESULTS: In 193 cases (88.1%) there was cyto-histological agreement but none in 26 (11.9%). Review of the discordant cases showed that in 2 (0.9%) there was invasion of the stromata to a depth greater than 3mm, and in 7 (3.2%) microinvasion, unsuspected via cytology; in 2 (0.9%) microinvasion was suspected via cytology but not confirmed by the final histological exam; and in 15 (6.8%) there was disagreement about the degree of CIN. CONCLUSION: The principal causes of error in the cytological exam were the lack of reliable morphological criteria for microinvasion, absence of sampling of the squamocolumnar junction, and scarcity of neoplastic cells in the sample. As for the histological exam, the errors were related to inadequate technical processing and underestimation of focal lesions.
46
Kuhn, Theresa, Adanna Ukazu, Pamela Ohman Strickland, et al. "The Effect of Forced Cough to Minimize Pain and Discomfort at the Time of Colposcopy-Guided Cervical Biopsy." Journal of Lower Genital Tract Disease 24, no. 2 (2020): 211–14. http://dx.doi.org/10.1097/lgt.0000000000000517.
Full text
47
Sharmila, Vijayan, Olivia Marie Jacob, Priyanka Yoga Purini, and Arundhathi Shankaralingappa. "Posthysterectomy Vaginal Vault Vaginal Intraepithelial Neoplasia: Successful Management through Transvaginal Approach." Journal of Colposcopy and Lower Genital Tract Pathology 3, no. 1 (2025): 33–36. https://doi.org/10.4103/jclgtp.jclgtp_6_25.
Full textAbstract:
Vaginal intraepithelial neoplasia (VaIN) is a premalignant condition of the lower reproductive tract of women. It may also be rarely seen in a hysterectomised woman, especially in cases where a hysterectomy is done for cervical intraepithelial neoplasia. There is a rising incidence of cases of VaIN, even in the group where hysterectomy was done for benign conditions. We present a case of 58-year-old multiparous woman who underwent a hysterectomy 15 years back due to abnormal uterine bleeding, probably fibroid. Vault cytology revealed HSIL, and colposcopy-guided biopsy revealed VaIN 3. We performed trans-vaginal wide local resection (upper vaginectomy) for our patient, and histopathology revealed VaIN 2. We emphasize the need for routine vault cytology for hysterectomised patients, even for benign indications, and transvaginal surgical approach for uncomplicated, unifocal HSIL lesions.
48
Samad, Khurshida, Imtiaz Ahmed, Touhid Uddin Rupom, Fouzia Jahan, and Shimul Akter. "Socio-demographic Characteristics and Incidence of CIN of Uterine Cervix among VIA Positive Women attended at a Tertiary Care Hospital in Dhaka City." Journal of Current and Advance Medical Research 7, no. 1 (2020): 7–11. http://dx.doi.org/10.3329/jcamr.v7i1.46423.
Full textAbstract:
Background: Women in different socio-demographic are presented with VIA positivity.
 Objective: The purpose of the present study was to see the socio-demographic characteristics and incidence of CIN of uterine cervix among of VIA positive women.
 Methodology: This cross sectional study was conducted in the Department Of Pathology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July 2007 to June 2008 for one (01) year. Patients who were colposcopically positive for cervical intraepithelial neoplasia and early invasive carcinoma or patients who are colposcopically negative but clinically suspicious for cervical neoplasia were included in this study. The clinical history was obtained by taking history with particular attention to age, age at marriage, parity, history of contraceptives, abnormal per vaginal discharge and post coital bleeding. The cervix was examined on naked eye by Cusco’s speculum to see whether it was healthy or not. Then it was examined by the colposcope after applying 3.0 to 5.0% acetic acid and colposcopic findings were collected. VIA positive cases were underwent colposcopy guided LEEP biopsy.
 Result: A total of 63 patients of different age group were recruited for this study. The mean with SD of age of this study population was 34.6±9.59 years. In this study, 41(65%) cases were diagnosed as cervical intraepithelial neoplasia (CIN). Incidence of CIN-I was 10 cases in age group 20 to 29 years. Most of the cases were in 30 to 39 (18 cases) years age group. Among 20 cases of high grade lesion (CIN-II/III) 9(45%) cases were in lower class, 8(40%) cases were in middle class and 3(15%) cases in upper class. Conclusion: In conclusion majority of the women were middle aged reproductive age group who are mostly in the lower class of socioeconomic class.
 Journal of Current and Advance Medical Research 2020;7(1): 7-11
49
Hassanati, Soule, Qin Fang, Yuanyuan Fang, and Yan Xing. "Clinical significance of HPV-HC2 in diagnosis and prognosis of cervical lesions: a retrospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 11 (2019): 4558. http://dx.doi.org/10.18203/2320-1770.ijrcog20194893.
Full textAbstract:
Background: To evaluate the human papillomavirus HC2 different range detection values and their clinical significance in prediction of CIN lesions grades as well as their role in the follow-up outcome after treatment.Methods: Using the hybrid capture 2 to detect and measure the HPV and the viral load quantity, we enrolled a total of 527 HPV positive women. All patients underwent thin prep liquid-based cytology test (TCT) and only 325 underwent colposcopy guided biopsy due to abnormal cytology results. All cytology and biopsy results were collected and analyzed according to the HPV viral load. Among these patients 108 patients were followed during 2years post-operatives and their prognosis results were collected and analyzed.Results: The proportion and severity of cytological abnormalities was positively correlated with the HPV-HC2 viral load (P<0.05). There was a positive correlation between cervical biopsy results and the HPV viral load P <0.05). The more the HPV-HC2 viral load was, the higher CIN2-3 grade percentage was getting. However no statically significant correlation was found between the HPV-HC2 viral load and the follow up outcomes after treatment (P>0.05).Conclusions: High HPV-HC2 viral load is significantly associated with the severity of cervical lesions (CIN), however it does not predict any further prognosis on follow-up after treatment.
50
Akhter, N., A. Khanam, and F. Begum. "Genital Tuberculosis An Uncommon Presentation." Journal of Bangladesh College of Physicians and Surgeons 30, no. 2 (2012): 108–11. http://dx.doi.org/10.3329/jbcps.v30i2.11421.
Full textAbstract:
A married women of 30 years, mother of one child, housewife was referred to out patient department of Khulna Medical College Hospital with history of blood stained vaginal discharge, secondary amenorrhoea for 3 years and evening rise of temperature and anorexia for 3 months. On speculum examination, cervix was oedematous, bright red in colour with papillary growth which bleeds on touch. She also had bilateral excavated lesion at the lowest part of the vagina close to the introitus which was red in colour with undermined edge. Visual inspection aided by acetic acid (VIA) was positive. Colposcopy guided biopsy was taken from unhealthy areas. There was extensive mottling on chest X-ary. She had high ESR, AFB+ve on sputum culture. The patient was diagnosed as a case of active pulmonary TB. Histopathological report of cervical tissue showed granulomatous lesion. Patient was given a regimen of standard anti TB drugs. After 2 weeks, during her first follow up, patient had few symptoms with regression of cervical growth and disappearance of vaginal ulcer. Patient herself stated about her wellbeing after the start of anti- TB drugs. Though cervical TB is not uncommon among genital TB (5-24%), vaginal tubercular lesion is very uncommon and concurrent pulmonary, endometrial, cervical and vaginal tuberculosis is a rare event. Careful evaluation is needed to diagnose tubercular infection in genital organs specially in GOPDs and colposcopy clinics. DOI: http://dx.doi.org/10.3329/jbcps.v30i2.11421 J Bangladesh Coll Phys Surg 2012; 30: 108-111