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Dissertations / Theses on the topic 'Combination dosage form'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Van, der Merwe Adriana Johanna. "Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil / van der Merwe, A.J." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7579.

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Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The rapid spread of resistance against antimalarial drugs, especially chloroquine and pyrimethamine–sulphadoxine, emphasises the need for new alternatives or modification of existing drugs. Artemisinin–based combination therapies (ACT’s) with different targets prevent or delay the development of drug resistance and therefore have been adopted as first–line therapy by all endemic cou

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2

Chetty, Prakash. "Development and assessment of propranolol sustained release dosage forms separately and in combination with hydrochlorothiazide." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1342/.

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3

Redelinghuys, Anne-Marie. "Quality specifications for antituberculosis fixed dose combination products / A-M. Redelinghuys." Thesis, North-West University, 2006. http://hdl.handle.net/10394/776.

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Objective: The World Health Organization (WHO) requested the Research Institute for Industrial Pharmacy, at the North-West University, Potchefstroom, South Africa, to develop monographs for anti-tuberculosis products for The International Pharmacopoeia (IntPh). These included monographs for rifampicin capsules; rifampicin tablets; isoniazid and ethambutol hydrochloride tablets; rifampicin and isoniazid tablets; rifampicin, isoniazid and pyrazinamide tablets; and rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride tablets. Background: Tuberculosis (TB), caused by Mycobacterium tube

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4

Muliaditan, Morris. "Development and dose rationale for drug combinations for the treatment of tuberculosis." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10058690/.

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Better, short treatment options are urgently needed for tuberculosis (TB). To meet this need, drug development in TB requires the use of new integrated methods to ensure the transition of suitable drugs and drug combinations into clinical development, which may ultimately lead to shortening of treatment duration. Despite the ongoing evaluation of new agents in preclinical stages of research, the translation of drug effects to humans along with the corresponding regimens remains empirical, in that novel regimens are progressed without consideration of target exposure or the underlying pharmacok

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5

Cronin-Fine, Drew. "Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72918.

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Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 63-67).<br>Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the U.S. healthcare system allows pharmaceutical companies to freely price their drugs. Then payers decide whether and how to cover these drugs. Payers have at their disposal several utilization management tools

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6

Zenker, Isabella. "A 13-week Dose Intensifying Simultaneous Combination Chemotherapy (DISC) Protocol for Malignant Lymphoma in Dogs." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-120732.

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7

Wang, Jie Stamey James D. "Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5182.

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8

Estefan, Dalia. "Predicting toxicity caused by high-dose-ratebrachytherapy boost for prostate cancer." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76216.

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Introduction Treating localized prostate cancer with combination radiotherapy consisting ofexternal beam radiotherapy (EBRT) and high-dose-rate brachytherapy (HDR-BT) has beenproven to result in better disease outcome than EBRT only. There is, however, a decreasingtrend in utilization of combination therapy, partially due to concerns for elevated toxicityrisks. Aim To determine which parameters correlate to acute and late (≤ 6 months) urinary toxicity(AUT and LUT) and acute and late rectal toxicity (ART and LRT), and thereafter createpredictive models for rectal toxicity. Methods Data on toxic

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9

Ebrahim, Salma. "The preformulation investigation of a combination anti-tuberculosis dosage form." Thesis, 1998. https://hdl.handle.net/10539/25753.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Science in Medicine (Pharmaceutical affairs) Johannesburg, 1998<br>Tuberculosis control in South Africa continues to be a major challenge with 90 000 new cases reported in 1995. Major contributory factors towards these epidemic proportions are patient non-compliance and the occurrence of drug resistant tuberculosis. Fixed drug combinations of anti-tuberculosis drugs have been reported to reduce the possibility of resistance arisi

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10

Ebrahim, Salima. "The pharmaceutical development of a fixed combination anti-tuberculosis dosage form." Thesis, 2014.

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This project is based on the assumption that there is scope for a more varied methodological approach in the in-service training of teachers and that, consultation with mature learners might be used to advantage. Durin g this study, an anti-tuberculosis extem poraneous pow der for suspension was optim ized in order to formulate a fixed com bination of rifam picin, isoniazid, pyrazinam ide and ethambutol hydrochloride as a powder to be reconstituted with water by the patient prior to adm inistration. Once an effective manufacturing m ethod was established, different suspending agents were e

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11

Ebrahim, Salima. "The pharmaceutical development of a fixed combination anti-tuberculosis dosage form." Thesis, 1998. http://hdl.handle.net/10539/22170.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand In partial fulfilment of the requirements for the degree of Master of Science in medicine (Pharmaceutical affairs) Johannesburg, 1998<br>Despite the availability of highly effective treatment regimens for tuberculosis, cure rates remain low for tuberculosis mainly due to patient non-compliance which results in the occurrence of multi drug resistance tuberculosis. To avoid the problem of further creation and propagation of multi drug-resistant tuberculosis, patients should be given fixed-dose c

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12

Van, der Watt Abel Hermanus. "Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination / Abel Hermanus van der Watt." Thesis, 2014. http://hdl.handle.net/10394/10809.

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Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached disturbingly high levels in South-East Asia and on the African continent. Consequently, there is a dire need for new drugs or formulations in the prophylaxis and treatment of malaria. Artesunate, an artemisinin derivative, represents a new category of antimalarials that is effective against drug-resistant Plasmodium falciparum strains and is of significance in the current antim

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13

Chang, Chia-Yuan, and 張家源. "The Medical Expenditure of Free Combination and Fix dose Combination for Treating Hypertension with Hyperlipidemia." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/5u3des.

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碩士<br>國立臺灣大學<br>健康政策與管理研究所<br>101<br>Background: Hypertension and Hyperlipidemia are the important risk factors of cardiovascular disease. Developed Countries are doing every effort to prevent and treat hypertension and hyperlipidemia. Objective: To compare the treatment results and expenditure between fix dose combination and free combination treatment of hypertension with hyperlipidemia patients. Method: The data of this study came from the National Health Insurance database released by the National Health Research Institute. Toally15,124 patients with hypertension and hyperlipidemia were id

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14

Robles-Martinez, P., X. Xu, S. J. Trenfield, et al. "3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method." 2019. http://hdl.handle.net/10454/17370.

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Yes<br>Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamo

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15

Seabi, Mmakgomo Eunice. "Formulation of carbamazepine and sodium valproate fixed dose combination for management of epilepsy." Thesis, 2019. http://hdl.handle.net/10386/3084.

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Thesis ((M. Pharm. (Pharmaceutics)) -- University of Limpopo, 2019<br>Epilepsy is the fourth most common neurological disorder after migraine, stroke and Alzheimer’s disease and it affects about fifty million people worldwide. Careful consideration should be taken when deciding to initiate treatment in epilepsy as it should consider the balance between the possibility of further seizures and their associated risks, including the possible risk of sudden expected death, inconvenience and the risks of taking regular medication for each individual. In the early 1980’s, the first-line treatment for

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16

Du, Manoir Jeanne Michelle. "Combination trastuzumab metronomic low-dose chemotherapy for the treatment of erbB2 overexpressing breast cancer." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95152&T=F.

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17

Joshi, Anjali. "Development and Evaluation of Fixed Dose Combination Orally Disintegrating Tablets of Antiretroviral Drugs for Pediatrics." 2012. http://digital.library.duq.edu/u?/etd,162264.

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The thesis work entails a bench-to-bedside translational research approach to the development of pediatric fixed dose combination of zidovudine/lamivudine/nevirapine (60/30/50mg) orally disintegrating tablets. A simple and cost-effective, direct compression method was used. Preformulation studies that included analytical and bio-analytical assay development, excipient selection and characterization of drug-excipient interaction for initial formulation were conducted. Response surface methodology was utilized to optimize the formulation in terms of disintegration time and crushing strength. Sta

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18

Hsieh, Hsin-Han, and 謝欣翰. "Effects of different combinations of modulation materials for lung dose distribution in proton therapy." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/2tfkt7.

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碩士<br>慈濟科技大學<br>放射醫學科學研究所<br>105<br>Abstract Proton therapy has different dose characteristics than photons used in conventional radiation therapy. After a short build-up region, conventional radiation shows an exponentially decreasing energy deposition with increasing depth in tissue. By contrast, protons show an increasing energy deposition with penetration distance leading to a maximum near the end of range of the proton beam, called the Bragg peak. The Bragg peak is too sharp to cover a target of any reasonable size. Incorporating the range modulator wheel, the Bragg peak can be transforme

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19

Kluberg, Sheryl. "Evaluating South African policies for linkage to and retention in HIV care using quasi-experimental methods." Thesis, 2017. https://hdl.handle.net/2144/27163.

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South Africa has the largest HIV-infected population in the world, with 2015 estimates of 7 million people living with HIV and 180,000 AIDS-related deaths. The South African government began scale-up of a public-sector HIV care and treatment program in 2004, and by the end of 2015, 3.4 million HIV-infected individuals were on antiretroviral therapy (ART). When scale-up began in South Africa, ART was only available to HIV-infected individuals with CD4 counts ≤200 cells/µL or WHO clinical stage 4 disease. In 2010, treatment was extended to patients who were pregnant or who had tuberculosis a

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20

Hobbs, Kim Melissa. "Development of a novel rate-modulated fixed dose analgesic combination for the treatment of mild to moderate pain." Thesis, 2010. http://hdl.handle.net/10539/8733.

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MSc (Med),Dept of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand<br>Pain is the net effect of multidimensional mechanisms that engage most parts of the central nervous system (CNS) and the treatment of pain is one of the key challenges in clinical medicine (Le Bars et al., 2001; Miranda et al., 2008). Polypharmacy is seen as a barrier to analgesic treatment compliance, signifying the necessity for the development of fixed dose combinations (FDCs), which allow the number of tablets administered to be reduced, with no associated loss in efficacy or in

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21

Zenker, Isabella [Verfasser]. "A 13-week dose intensifying simultaneous Combination chemotherapy (DISC) protocol for malignant lymphoma in dogs : 21 cases / vorgelegt von Isabella Zenker." 2010. http://d-nb.info/1007630116/34.

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