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Dissertations / Theses on the topic 'Combination of drugs'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Shi, Yun, and 施昀. "Escalation with overdose control for phase I drug-combination trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B49799733.

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The escalation with overdose control (EWOC) method is a popular modelbased dose finding design for phase I clinical trials. Dose finding for combined drugs has grown rapidly in oncology drug development. A two-dimensional EWOC design is proposed for dose finding with two agents in combination based on a four-parameter logistic regression model. During trial conduct, the posterior distribution of the maximum tolerated dose (MTD) combination is updated continuously in order to find the appropriate dose combination for each cohort of patients. The probability that the next dose combination excee

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2

Almoyad, Muhammad. "Synergism from combination of targeted therapy and phytochemicals in colorectal cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18161.

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Colorectal cancer is the second most common cancer in women and third in men, accounting for 9.7 % of all cancers incidence. Oxaliplatin is a platinum-based anticancer drug used typically in combination with folinic acid and 5-fluorouracil for treatment against colorectal cancer. However, numerous side effects such as nausea and vomiting, GI toxicity, anaemia, immunodeficiency, ototoxicity, nephrotoxicity, and neurotoxicity are associated with its use. These can be decreased by lowering dose of oxaliplatin. Phytochemicals that can act as antioxidants have been used by people in treatment again

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3

Al, Onazi Fahad Nasser. "Platinum drugs given in combination with phytochemicals to enhance platinum action." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18971.

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This study focused on the sequenced combinations of platinum drugs cisplatin and oxaliplatin and four phytochemicals celastrol, guggulsterone, garcinol and ellagic acid administered to human ovarian lines A2780, A2780cisR and A2780ZD0473R. Among the phytochemicals, celastrol is most active having comparable activity against all the three ovarian tumour models. As applied to binary combinations of platinum drugs and the phytochemicals, it was found that generally synergism was greater at higher concentrations (ED75 and ED90) of drugs than at lower concentrations (ED50) in all three cell lines.

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Bali, Hana. "Synergism from combination of platinum drugs and selected phytochemicals in colorectal cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18798.

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Colorectal cancer is the second most leading cause of death among all reported cancer mortality. Chemotherapy is the treatment of choice to treat metastasized colorectal cancer patients. Combined administration of drugs having different mechanism of actions has been demonstrated better efficacy than conventional monotherapy. Epidemiological data suggests that consumption of phytochemicals has a great impact in prevention and treatment of colorectal cancer. In this study four phytochemicals including curcumin, colchicine, EGCG and taxol were combined with cisplatin and oxaliplatin in a binary m

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5

Yang, Jianning. "Mechanism-Based Computational Models to Study Pharmacological Actions of Anticancer Drugs." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1249622434.

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6

Siau, Hong. "The effects of antifungal drugs in combination on the growth of Candida species." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359415.

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7

Kaelen, Mendel. "The psychological and human brain effects of music in combination with psychedelic drugs." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/55900.

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This research investigated how psychedelics and music work together in the brain and modulate subjective experience. Chapter 1 highlighted the prominent role of music in psychedelic therapy in the 1950s and 1960s, and how music continues to be used in modern psychotherapeutic trials with psychedelics. Although ‘psychedelic therapy’ shows promising findings for mental health care, little is known empirically about the therapeutic functions of music. The primary objective of this thesis was to address this knowledge gap, via studying the effects of psychedelics and music on human brain function

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8

Cronin-Fine, Drew. "Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72918.

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Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 63-67).<br>Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the U.S. healthcare system allows pharmaceutical companies to freely price their drugs. Then payers decide whether and how to cover these drugs. Payers have at their disposal several utilization management tools

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9

McLeese, Michelle Frances. "Increases in Drug and Alcohol Problems: A Combination of Job and Home Stressors?" Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/30846.

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Using data from the National Comorbidity Survey (NCS) from the Fall of 1990 to the Spring of 1992 among respondents between the ages of 15 and 54 in 48 of the contiguous United States, this paper hypothesized an increase in serious drug problems and serious alcohol problems when a combination approach was used regarding home and work stressors. Results indicate support for the hypotheses that the combination of home and work stressors leads to an increase in both serious drug and alcohol problems (each measured separately). These findings are important especially since they suggest that stre

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10

Soble, Michelle Joy 1961. "THE EFFECTS OF GLUTATHIONE DEPLETION BY L-BUTHIONINE-(S,R) SULFOXIMINE ON THE ANTITUMOR EFFICACY OF MODEL SULFHYDRYL-DEPENDENT ANTICANCER AGENTS (BSO)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276859.

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11

Luu, Yao, Jim Thigpen, and Stacy D. Brown. "Stability of Sildenafil in Combination with Heparin and Dopamine." Digital Commons @ East Tennessee State University, 2017. https://doi.org/10.2146/ajhp150853.

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Purpose:The stability of sildenafil in combination with heparin and dopamine was evaluated. Methods:A stability-indicating high-performance liquid chromatography method with ultraviolet detection was developed for sildenafil citrate and validated. The method was applied to the investigation of sildenafil alone, sildenafil with heparin, sildenafil with dopamine, and sildenafil with heparin and with dopamine, all in 5% dextrose injection at room temperature and under refrigeration for 30 days. Samples of 100 μL were pulled from each storage bottle on each sampling day, diluted in mobile phase, a

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12

Wang, Jie Stamey James D. "Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5182.

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13

Almeida, Neto Abílio César de. "Training community pharmacists in cognitive-behavioural intervention strategies for optimising the monitoring of non-prescription combination analgesic products." Connect to full text, 2000. http://hdl.handle.net/2123/833.

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Thesis (Ph. D.)--University of Sydney, 2000.<br>Includes tables. Title from title screen (viewed Apr. 23, 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Dept. of Psychology, Faculty of Science. Includes bibliography. Also available in print form.

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14

Bach, Nielsen Anders. "Use of the combination of prodrug design and salt optimization - a strategy to enchance aqueous solubility of drugs /." Cph. : Department of Pharmaceutics, the Danish university of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/AndersBachNielsen.htm.

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15

Kim, Sung Woo. "Combining Noxa-Inducing Drugs with ABT-263 to Efficiently Increase Cell Death in Head and Neck Squamous Cell Carcinoma (HNSCC)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4847.

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Head and neck cancer is the sixth leading cancer worldwide. Head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of incident cases. Despite intense, multimodality treatment regimens for HNSCC including surgery, chemotherapy, and radiation, little progress has been made over the past 30 years in improving overall survival rates. Tumor cell death induced by both conventional and targeted chemotherapy is often mediated by the BCL-2 family-dependent mitochondrial apoptotic pathway. However, initiators of this apoptotic pathway, such as p53, are more than 50% of the time muta

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16

Du, Plessis-Stoman Debbie. "A combination of platinum anticancer drugs and mangiferin causes increased efficacy in cancer cell lines." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1016160.

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This thesis mainly deals with some biochemical aspects regarding the efficacy of novel platinum anticancer compounds alone and in combination with mangiferin, as part of a broader study in which both chemistry and biochemistry are involved. Various novel diamine and N-S donor chelate compounds of platinum II and IV have been developed in which factors such as stereochemistry, ligand exchange rate and biocompatibility were considered as additional parameters. In the first order testing, each of these compounds was tested with reference to their “killing” potential by comparing their rate of kil

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17

Anwar, MD Sheikh. "Natural compounds in combination with platinum drugs administered to ovarian cancer models towards synergistic outcomes." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18714.

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Ovarian cancer is known as one of the dreaded diseases due to its low five years’ survival, acquired drug resistance and recurrence. It is treated mainly by platinum drugs given alone or in combination with paclitaxel. However, problems of drug resistance that is often acquired still remain. While resistance to platinum drugs at the molecular level can be due to overexpression of nuclear factor kappa B (NF-κB) and protein kinase B (AKT/PKB) pathways, it is believed that phytochemicals and other natural compounds can inhibit expression of NF-κB and AKT/PKB. This study aimed to apply binary comb

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18

Gabriels, Gary Anthony. "Determination of the effect of blood testing intervals on bioavailability and bioequivalence assessment of fixed-dose drug combination anti-tuberculosis drugs." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/3387.

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19

Svensson, Åsa. "Application of a New Logic to Old Drugs: Angiogenesis Inhibition in Neuroblastoma." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3458.

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<p>Neuroblastoma is one of the most common solid cancers of early childhood. In Sweden, approximately 10-15 cases occur annually. The overall five-year neuroblastoma survival in Europe is approximately 45%. Since cancer treatment involves drugs with risks of side effects in the growing child, there is a need for more effective and less toxic drugs. One new approach in cancer treatment is inhibition of tumor angiogenesis, i.e., of new blood vessel growth into the tumor. An angiogenesis inhibitor may be combined with cytostatic drugs to enhance the efficacy. The aim of this study was to investig

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20

Chetty, Prakash. "Development and assessment of propranolol sustained release dosage forms separately and in combination with hydrochlorothiazide." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1342/.

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21

Lövgren, Ulf. "Enzyme immunoassay in combination with liquid chromatography for sensitive and selective determination of drugs in biosamples." Lund : Dept. of Analytical Chemistry, Lund University, 1997. http://books.google.com/books?id=Ju1qAAAAMAAJ.

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22

Radhakrishnan, Suresh. "Enhancement of anti-tumour activity by combination of cytotoxic drugs and replication-selective adenoviruses to target prostate cancer." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498525.

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23

Bhattacharya, Bhaskar. "Inhibitors of phosphoinositide 3-kinase (PI3K)/AKT pathway in combination with cytotoxic drugs in human ovarian cancer cell lines." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502454.

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24

Shahiduzzaman, Md. "Combination of cell culture and quantitative PCR (cc-qPCR) for assessment of efficacy of drugs and disinfectants against Cryptosporidium parvum." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-20100316-075533-2.

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Cryptosporidium parvum is an obligatory intracellular parasitic protist that belongs to the phylum Apicomplexa. Cryptosporidiosis is an infection for which no satisfactory efficient curative treatment is known, especially in immunocompromised individuals. Furthermore, the parasite oocysts show considerable tenacity in the environment. Therefore, new potent drugs along with a simple and reliable experimental model for evaluation of anticryptosporidial measures are urgently needed. The present studies were undertaken to establish a combined cell culture and quantitative PCR assay (cc-qPCR) to as

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25

Sabatino, Maria Antonietta. "Combination treatments in in vitro and in vivo models between molecules reverting epigenetic gene silencing and DNA-interacting anticancer drugs." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502390.

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Epigenetic transcriptional gene silencing plays a fundamental role in cancer development and has been considered as a target for cancer therapy in the last few years, mainly due to its reversibility by small molecules. Among the several methylated genes investigated, glutathione-S-transferase CGST) PI, a protein belonging to cellular detoxification systems, has been shown to be extensively promoter-methylated in prostate cancer. My study therefore describes a new therapeutic approach against prostate cancer, based on the combination of demethylating agents and brostallicin, a DNA minor groove

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26

Jabbar, Shireen Arjumand Bano. "The response of human lung cancer cell lines to interferons and tumour necrosis factor, alone or in combination with cytotoxic drugs." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335163.

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27

Liu, Fang. "Innovative local delivery of anticancer drugs in combination with an immunomodulatory tumor-targeting monoclonal antibody improves long-lasting antitumor effects in melanoma." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2025. http://www.theses.fr/2025UMONT004.

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L'approbation des inhibiteurs de points de contrôle immunitaires a considérablement amélioré le pronostic des patients atteints de mélanome métastatique, un cancer autrefois associé à l'un des pires pronostics. Cependant, le taux de réponse à ces thérapies reste inférieur à 50 %. Parallèlement, les thérapies ciblées qui visent les mutations les plus courantes (BRAFmut) dans le mélanome ont également transformé le paysage thérapeutique. Ces molécules agissent rapidement sur la croissance tumorale et ont notablement amélioré le taux de survie médian. Cependant, cet effet est souvent de courte du

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28

Do, Monte Fialho Murteira Susana Claudia. "Drug repurposing and market access : conditions and determinants for price, reimbursement and access of reformulated and repositioned drugs in the United States of America and Europe." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10115.

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Le développement de novo de médicaments est un processus long et coûteux. De plus en plus, les développeurs de médicaments cherchent à mettre en oeuvre des stratégies rentables et à moindre risque pour le développement de produits pharmaceutiques. Le processus de trouver de nouveaux usages pour des médicaments existants en dehors de l'indication initiale pour laquelle ils ont été initialement approuvé est couramment désigné comme « repositionnement », « réorientation » ou « reprofilage ». Le développement de formulations différentes pour un même médicament pharmaceutique est communément désign

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29

Pang, Christina Lynn. "Effects of Inhaled Combination Corticosteroid Drugs on Aerodynamic Measures of Phonation and Visual-Perceptual Measures of Vocal Fold and Arytenoid Tissue in Excised Rabbit Larynges." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/8934.

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The purpose of this thesis is to examine the effects of inhaled corticosteroid drugs (ICs) on the voice due to their frequent use in treating an increasing prevalence of asthma disorders. As part of a larger five-year study, the focus of this thesis is specifically on whether 8 weeks of in vivo exposure to ICs will cause changes in the sustained subglottal pressure, sustained airflow, and visual-perceptual ratings of edema and erythema in excised rabbit larynges. Researchers administered either ICs or a control nebulized isotonic saline solution to 22 rabbits in vivo, sacrificed them, and harv

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30

Momodu, Rametu Omamegbe. "Knowledge and practices of patent medicine vendors in the use of artemisinin based combination therapy in the treatment of malaria in an urban community in Lagos." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2704_1271017667.

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<p>Malaria is a health, social and economic burden in Nigeria and consistently ranks amongst the four most common causes of childhood deaths. Treatment of malaria is usually started at home<br>care is only sought from the health facility when the treatment is ineffective (McCombie, 1996). Patent medicine vendors (PMVs) have been identified as a widely patronized source for drugs used in the home treatment of malaria (Breiger et al, 2001<br>Goodman, et al, 2007<br>Salako et al, 2001). Inadequate or poor knowledge and practices in the use of anti-malaria drugs (AMDs) increases morbidity and mort

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31

Zikusooka, Charlotte Muheki. "Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/7439.

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Includes bibliographical references (p. 253-265)<br>This study seeks to use the techniques of cost-effectiveness analysis to evaluate, within the context of effective vector control, the change to artemisinin-based combination therapies (ACTs) as first line malaria treatment and to evaluate the relevance of using definitive diagnosis (as opposed to clinical diagnosis) as the basis for initiating malaria treatment, especially when using ACTs for treatment. The cost-effectiveness of ACTs was evaluated in two study sites (i.e. In Kwazulu Natal which switched from SP monotherapy to AL in 2

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32

Mojica, Muñoz Ann-Katrin [Verfasser], and Wolfgang [Akademischer Betreuer] Siess. "Effect of GPVI-Fc in combination with standard antiplatelet drugs and of GPVI-Fc fused to CD39 on platelet thrombus formation / Ann-Katrin Mojica Muñoz ; Betreuer: Wolfgang Siess." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1196009104/34.

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33

Соцька, Я. А., І. О. Шаповалова, І. М. Баскаков, Л. П. Антонова та Р. А. Нужний. "Вплив комбінації циклоферону і зітрокса на ефективність лікування хворих з тяжким перебігом гострого тонзиліту". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/37934.

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У даний час відзначається суттєве збільшення частоти захворювання пацієнтів тяжкими формами гострого тонзиліту, а також і іншими стрептококовими інфекціями. Метою роботи було вивчення впливу комбінації зітрокса і циклоферона на біохімічні та імунологічні показники у хворих з тяжким перебігом гострого тонзиліту.

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34

Abrahams, Beynon. "The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/3846.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. Inhibition of cell growth by TKIs used individually occurred in a dose- and time-dependent manner. When EGFR Inhibitor I, EGFR Inhibitor II/BIBX1382 and the multi-specific EGFR/ErbB-2/ErB-4 Inhibitor were used in combination with each other at equimolar log dose concentrations, the combined effects on cell growth was sign

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Haddad, Tarek [Verfasser], and Klaus [Akademischer Betreuer] Kümmerer. "The Fate of Antibiotics and Anticancer Drugs in the Aquatic Environment - Evaluating the Photolysis of Ciprofloxacin and Monitoring the Course of its Genotoxicity by a Combination of Experimental and In Silico Testing / Tarek Haddad. Betreuer: Klaus Kümmerer." Lüneburg : Universitätsbibliothek der Leuphana Universität Lüneburg, 2016. http://d-nb.info/1102524395/34.

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Kao, Lie-Jane. "Designs for drug combination experiments /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu14878493772931.

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Khaleel, Nareman Dahshan Henedaq [Verfasser], Klaus [Akademischer Betreuer] Kümmerer, Ralf [Gutachter] Ebinghaus, and Carolin [Gutachter] Floeter. "Fate of psychotropic drugs in the aquatic environment : Assessment of dead-end photo-degradation products generated under varying conditions by combination of experimental and "in-silico" methods / Nareman Dahshan Henedaq Khaleel ; Gutachter: Ralf Ebinghaus, Carolin Floeter ; Betreuer: Klaus Kümmerer." Lüneburg : Leuphana Universität Lüneburg, 2021. http://d-nb.info/1237497469/34.

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Tsai, Hsing-Chuan. "Optimal designs for drug combination experiments /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488193272068802.

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Omollo, Charles. "Developing methods to prioritize in vitro drug combinations against Mycobacterium tuberculosis: fusidic acid as potential combination partner with known antitubercular agents." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25432.

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The tuberculosis (TB) epidemic remains a major threat to public health globally, and is exacerbated by the escalating number of multi-drug resistant cases. These factors have highlighted the urgent need for new effective therapies or different approaches to augment the efficacy of current anti-TB drugs. Synergistic drug combinations present a feasible strategy towards expanding TB treatment options. Despite reported successes with combination screening, as well as the current reliance on combination therapy for TB, this approach remains largely underexplored. Evidence suggests that utilizing s

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Tam, Stanton Sui Yin. "Anticancer Drug Combinations to Overcome Drug Resistance in Breast Cancer." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27733.

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For triple negative breast cancer (TNBC) patients, taxanes are the mainstays of chemotherapy but remain susceptible to resistance. Combination therapy of paclitaxel/docetaxel and tyrosine kinase inhibitors (TKIs) improves overall response rates in TNBC patients. Ixabepilone, mechanistically similar to taxanes, shows efficacy in TNBCs refractory to paclitaxel/docetaxel. Yet, there is a lack of studies on ixabepilone-TKI combinations. The first aim was to investigate the efficacy of these combinations in docetaxel-resistant MDA-MB-231 (TXT) cells and parental non-resistant MDA-MB-231 (231C) cell

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41

Farebrother, Joanna E. "Statistical design and analysis of factorial combination drug trials." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264855.

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MAUCERI, MATTEO. "New Targeted Molecules for the Therapy of Ovarian Cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3031106.

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Patients with high-grade serous ovarian cancer (HGSOC), the most aggressive epithelial ovarian cancer (EOC) subtype, have a 5-year survival rate of about 93% when diagnosed at an early stage, but it drops to 30-40% when diagnosed in the advanced stage. HGSOC aggressiveness is mainly caused by the late diagnosis (51% stage III, 29% stage IV) when the tumor has already spread in the peritoneal cavity. PIN1 is a unique peptidyl-prolyl isomerase that targets the phosphorylated Ser/Thr(Pro) motifs to regulate several key proteins in different signaling pathways. Pin1 is overexpressed in several can

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Muangnoicharoen, Sant. "The clinical pharmacology of artemisinin based drug combinations." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502574.

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This thesis focuses on the clinical efficacy, pharmacokinetics and pharmacodynamics of artemisinin based drugs and their combinations for their treatment of P. falciparu11l malaria. The aims of the thesis are to get a better understanding of the basic pharmacology of artemisinin type drugs and their combinations. Chapter I is introduction and general knowledge about malaria disease, antimalarial drugs, treatment and drugs resistance. Chapter 2 determines parasite drug susceptibility and drug interaction of dihydroartemisinin and the quinoline type drug, piperaquine, used together as a fixed do

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Chaerunisaa, Anis Yohana [Verfasser]. "Release adjustment of drug combinations with different drug solubility / Anis Yohana Chaerunisaa." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1048327388/34.

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Harrison, Luke Robert Edward. "Optimising treatment with combinations of novel anti-kinase drugs and cytotoxic therapy." Thesis, University of Newcastle upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489290.

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Aim: To investigate the mechanism of potentiation of cytotoxic drugs by NU2058 (06-cyclohexylmethyl guanine), which had been synthesised as a cyclin-dependent kinase 2 (CDK2) inhibitor. One hundred and forty four structurally related compounds to NU2058 were screened for their ability to potentiate cisplatin cytotoxicity in SQ20b human cancer cells. Sixty six compounds> increased cisplatin cytotoxicity; however, no relationship between CDK2 enzyme inhibition (assessed by immunoblotting for phospho_Rb1 821 protein - a target of CDK2) and cisplatin potentiation was observed. Compound NU6242 was

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Najem, Ahmad. "Drug combination strategies to abrogate resistance in NRAS mutant melanoma." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/258096.

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Melanoma is the deadliest form of skin cancer and one of the most difficult cancers to treat. Gene alterations identified in melanoma pointed to distinct molecular subsets of tumors with direct implications in therapeutic strategies. Activating mutations in NRAS, found in 20-30% of melanomas have been associated with aggressive clinical behavior and a poor prognosis. Nevertheless, there is lack of effective targeted therapies for NRAS mutant melanoma.Out of the few MEK inhibitors, pimasertib, a potent inhibitor of both MEK1 and MEK2 has showed promising results in NRAS mutant advanced melanoma

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Obszynska, Jolanta Agnieszka. "Investigations of genomic changes induced by the FAC drug combination." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/30768.

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At the present, researchers are not able to predict which individual patients might be susceptible to developing AML. Current research carried out in various laboratories is focused on identifying potential markers that would allow for identification of such patients. The analysis of gene expression profiles of cells treated with the FAC drug regime gave an insight on the impact that the chemotherapeutics have on non-cancerous cells. Exposure to the FAC drug regime caused many changes in gene expression profiles of treated cells. Experiments examining the impact of single doses treatments and

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Sgueglia, Umberto. "Predicting Novel Drug-drug Interactions based on structured knowledge in combination with text mining approaches." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15494/.

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Molto spesso le persone in cura presso gli ospedali possono soffrire di strani effetti collaterali di cui non si conosce minimamente l’origine. In alcuni casi questo può derivare da una sbagliata prescrizione di medicinali al paziente. Ben noto nella medicina sono gli effetti che una medicina può causare somministrata con un altra allo stesso tempo. Quello che non si conosce, è il risultato di una somministrazione multipla, ovvero quando più medicinali vengono somministrati contemporaneamente. Il problema che vogliamo affrontare in questa tesi è quello di capire se sia possibile usare le i

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Regan-Fendt, Kelly E. "Integrative Network and Transcriptomics Approach Enables Computational Drug Repurposing and Drug Combination Discovery in Melanoma." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1521209048981327.

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Schmitt, Christina Verfasser], Kirsten [Akademischer Betreuer] [Hattermann, and Regina [Gutachter] Scherließ. "Influence of neuroimplant materials, drugs and drug-material combinations on healthy cells of the brain / Christina Schmitt ; Gutachter: Regina Scherließ ; Betreuer: Kirsten Hattermann-Koch." Kiel : Universitätsbibliothek Kiel, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:8-mods-2020-00182-0.

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