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Relevant bibliographies by topics / Combinatorial library screening technologies

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Academic literature on the topic 'Combinatorial library screening technologies'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Combinatorial library screening technologies"

1

Gordon, Eric M., Ronald W. Barrett, William J. Dower, Stephen P. A. Fodor, and Mark A. Gallop. "Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions." Journal of Medicinal Chemistry 37, no. 10 (1994): 1385–401. http://dx.doi.org/10.1021/jm00036a001.

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GORDON, E. M., R. W. BARRETT, W. J. DOWER, S. P. A. FODOR, and M. A. GALLOP. "ChemInform Abstract: Applications of Combinatorial Technologies to Drug Discovery. Part 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions." ChemInform 25, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199439303.

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Hamann, Andrew, Alvin K. Thomas, Tyler Kozisek, et al. "Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection." Experimental Biology and Medicine 245, no. 7 (2020): 606–19. http://dx.doi.org/10.1177/1535370220913501.

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Nonviral gene delivery, though limited by inefficiency, has extensive utility in cell therapy, tissue engineering, and diagnostics. Substrate-mediated gene delivery (SMD) increases efficiency and allows transfection at a cell-biomaterial interface, by immobilizing and concentrating nucleic acid complexes on a surface. Efficient SMD generally requires substrates to be coated with serum or other protein coatings to mediate nucleic acid complex immobilization, as well as cell adhesion and growth; however, this strategy limits reproducibility and may be difficult to translate for clinical applicat

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Appell, Kenneth C., Thomas D. Y. Chung, Michael J. H. Ohlmeyer, Nolan H. Sigal, John J. Baldwin, and Daniel Chelsky. "Biological Screening of a Large Combinatorial Library." Journal of Biomolecular Screening 1, no. 1 (1996): 27–31. http://dx.doi.org/10.1177/108705719600100111.

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Encoding technology has allowed for the creation of libraries of 50,000 or more low-molecular-weight compounds for biological testing. The current challenge is to properly and efficiently screen among these compounds for useful biological activities. In this example, actives against two related G-protein coupled receptors were sought from a combinatorial library of 56,000 members. The library was synthesized on solid phase using the split synthesis method and photochemically released for testing. At a screening concentration of 0.5-1 /LM, 86 unique structures were identified as active against

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Pötzelberger, Isabella, Andrei Ionut Mardare, and Achim Walter Hassel. "Copper-nickel combinatorial library screening for electrocatalytic formaldehyde oxidation." physica status solidi (a) 214, no. 9 (2016): 1600552. http://dx.doi.org/10.1002/pssa.201600552.

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Chu, Yen-Ho, Xu Zang, and Jian Tu. "Affinity Capillary Electrophoresis: From Binding Measurement to Combinatorial Library Screening." Journal of the Chinese Chemical Society 45, no. 6 (1998): 713–20. http://dx.doi.org/10.1002/jccs.199800108.

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Poulsen, Sally-Ann. "Direct screening of a dynamic combinatorial library using mass spectrometry." Journal of the American Society for Mass Spectrometry 17, no. 8 (2006): 1074–80. http://dx.doi.org/10.1016/j.jasms.2006.03.017.

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Ramström, Olof, Lei Ye, and Klaus Mosbach. "Screening of a combinatorial steroid library using molecularly imprinted polymers." Analytical Communications 35, no. 1 (1998): 9–11. http://dx.doi.org/10.1039/a707876e.

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Doudican, Nicole A., Shireen Vali, Shweta Kapoor, et al. "Ex Vivo Patient-Specific Validation Of Personalized Therapeutic Designed For Multiple Myeloma." Blood 122, no. 21 (2013): 4219. http://dx.doi.org/10.1182/blood.v122.21.4219.4219.

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Abstract Background The unique signature of a patient’s tumor mandates the need to rationally design personalized therapies employing N=1 segmentation conceptually. Repurposing of existing drug agents with validated clinical safety and pharmacokinetics data provides a rapid translational path to clinic which otherwise would require years of development time and associated new chemical risks. By focusing on rationally designed personalized treatment mechanisms, our strategy targets multiple key pathways to address the clinical problem of emergence of single therapy resistance. In order to overc

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Shumate, Chris, Scott Beckey, Peter Coassin, and Harry Stylli. "Ultra-High Throughput Screening." Laboratory Automation News 2, no. 4 (1997): 24–29. http://dx.doi.org/10.1177/221106829700200406.

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Aurora Biosciences Corporation designs and develops proprietary drug discovery systems, services and technologies to accelerate and enhance the discovery of new pharmaceuticals. Aurora is developing an integrated technology platform centered around two technologies; 1) a portfolio of proprietary fluorescent assay technologies and, 2) an ultra-high throughput screening (“UHTS”) system designed to allow assay miniaturization and to overcome many of the limitations associated with the traditional drug discovery process. This approach takes advantage of the opportunities created by recent advances

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Dissertations / Theses on the topic "Combinatorial library screening technologies"

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Lim, Wai-May. "Construction and screening of a combinatorial shiga toxin library." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0007/MQ40784.pdf.

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Brown, Jennifer Marie. "Synthesis and Screening of a Combinatorial Peptide Library for Ligands to Target Transferrin: Miniaturizing the Library." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30440/.

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Combinatorial libraries are used in the search for ligands that bind to target proteins. Fmoc solid-phase peptide synthesis is routinely used to generate such libraries. Microwave-assisted peptide synthesis was employed here to decrease reaction times by 80-90%. Two One-Bead-One-Compound combinatorial libraries were synthesized on 130μm beads (one containing 750 members and the other 16, 807). The use of smaller solid supports would have many important practical advantages including; increased library diversity per unit mass, smaller quantities of library needed to generate hits, and screening

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Chen, Xianwen. "PROFILING THE SUBSTRATE SPECIFICITY OF PROTEIN TYROSINE PHOSPHATASES BY COMBINATORIAL LIBRARY SCREENING." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1315341322.

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Wang, Peng. "Screening Combinatorial Peptide Library for Optimal Enzyme Substrates and High Affinity Protein Ligands." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039797438.

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Trinh, Thi Ba. "Synthesis and Screening of Peptide Libraries for Biological Applications." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405520102.

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Hutchings, K. D. "High throughput combinatorial screening of Cu-Zn-Sn-S thin film libraries for the application of Cu2ZnSnS4 photovoltaic cells." Thesis, Cranfield University, 2014. http://dspace.lib.cranfield.ac.uk/handle/1826/8771.

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The naturally occurring mineral of Cu2ZnSnS4 (CZTS) is a promising alternative absorber layer for thin film based photovoltaic devices. It has the remarkable advantage that it consists of abundant, inexpensive and non-toxic elements compared to its crystallographically related and highly successful counterparts: the Cu(In,Ga)(S,Se)2 (CIGSSe) and CuIn(S, Se)2 (CISSe) material systems. Therefore, there is real commercial potential for reduced material costs and improved device efficiencies. A two-stage high throughput combinatorial process for the fabrication of Cu-Zn-Sn-S thin film libraries is

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Freedman, Benjamin Gordon. "Degenerate oligonucleotide primed amplification of genomic DNA for combinatorial screening libraries and strain enrichment." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/71346.

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Combinatorial approaches in metabolic engineering can make use of randomized mutations and/or overexpression of randomized DNA fragments. When DNA fragments are obtained from a common genome or metagenome and packaged into the same expression vector, this is referred to as a DNA library. Generating quality DNA libraries that incorporate broad genetic diversity is challenging, despite the availability of published protocols. In response, a novel, efficient, and reproducible technique for creating DNA libraries was created in this research based on whole genome amplification using degenerate oli

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Joo, Sang Hoon. "Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195561420.

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Rabal, Gracia Obdulia. "Herramientas de cribado virtual aplicadas a inhibidores de tirosina quinasas. Contribución al desarrollo del programa PRALINS para el diseño de quimiotecas combinatorias." Doctoral thesis, Universitat Ramon Llull, 2006. http://hdl.handle.net/10803/9303.

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L'aplicació de mètodes de cribatge virtual adquireix cada vegada més importància en el procés de descobriment de fàrmacs, complementant a les tècniques de High-throughput screening per tal de facilitar i contribuir a la comprensió dels mecanismes bioquímics d'actuació dels fàrmacs, donar agilitat i reduir el cost del procés.<br/><br/>Pel que fa a la present tesi, l'interès farmacològic és la inhibició de receptors de tirosina cinases. Aquests enzims participen en múltiples processos de senyalització cel·lular, fet que fa que tant la disfunció de les mateixes o el seu paper privilegiat en els m

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Van, Blarcom Thomas John. "Antibody discovery and engineering using the anchored periplasmic expression (APEx) Escherichia coli display system with flow cytometric selection." 2009. http://hdl.handle.net/2152/6903.

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The development of recombinant proteins for therapeutic applications has revolutionized the pharmaceutical industry. In particular, monoclonal antibodies are the safest class of all therapeutic molecules and account for the majority of recombinant proteins currently undergoing clinical trials. A variety of technologies exist to engineer antibodies with a desired binding specificity and affinity, both of which are a prerequisite for therapeutic applications. This dissertation describes the implementation of a novel combinatorial library screening technology for the discovery and engineering of

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Books on the topic "Combinatorial library screening technologies"

1

Lim, Wai-May. Construction and screening of a combinatorial shiga toxin library. National Library of Canada, 1998.

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Integrated Drug Discovery Technologies. CRC, 2002.

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High-Throughput Lead Optimization in Drug Discovery (Critical Reviews in Combinatorial Chemistry). CRC, 2008.

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(Editor), John Sterling, Ellyn Kerr (Editor), and Shannon Simons (Editor), eds. Methods and Technologies in Drug Discovery. Mary Ann Liebert, Inc., 2005.

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High-throughput lead optimization in drug discovery. CRC Press, 2008.

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Tushar, Kshirsagar, ed. High-throughput lead optimization in drug discovery. CRC Press, 2008.

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7

Hobbs, Renee, Liz Deslauriers, and Pam Steager. The Library Screen Scene. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190854317.001.0001.

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Throughout life, people use film, videos, and media for entertainment and learning. In an increasing number of school, public, and academic libraries, people get opportunities to screen and discuss movies, make short animations, learn to edit videos, and develop a sense of community and civic engagement through shared media experiences. Through innovative programs, services, and collections, libraries are helping people acquire film and media literacy competencies. This book reveals five core practices used by librarians who care about film and media: viewing, creating, learning, collecting, a

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Book chapters on the topic "Combinatorial library screening technologies"

1

Gao, Suogang, Zengti Li, Jiangchen Yu, Xiaofeng Gao, and Weili Wu. "DNA Library Screening, Pooling Design and Unitary Spaces." In Combinatorial Optimization and Applications. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02026-1_5.

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Barredo, G. R., S. L. Saavedra, M. C. Martínez-Ceron, et al. "Design of Affinity Chromatography Peptide Ligands Through Combinatorial Peptide Library Screening." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0775-6_16.

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Ngo, Hung, and Ding-Zhu Du. "A survey on combinatorial group testing algorithms with applications to DNA Library Screening." In DIMACS Series in Discrete Mathematics and Theoretical Computer Science. American Mathematical Society, 2000. http://dx.doi.org/10.1090/dimacs/055/13.

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Georgiou, George, and Barrett R. Harvey. "Applications of Flow Cytometry in Protein Engineering." In Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.003.0017.

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In recent years, the application of evolutionary methods for protein engineering has created tremendous optimism regarding our ability to generate proteins with tailored functional properties such as ligand binding, improved stability, allostery, and catalytic activity. The power of directed protein evolution lies in its simplicity : First, a gene encoding a polypeptide is subjected to mutagenesis, and the resulting ensemble of mutated genes is expressed in a suitable cellular host. Second, the population of expressed proteins is subjected to a screening process. Often, multiple rounds of screening are required to isolate the rare clones within the population that can satisfy the functional screen. Third, DNA is isolated from the enriched clones and subjected to additional rounds of mutagenesis and screening under increasingly stringent conditions. This iterative process is repeated several times until either little functional improvement is observed between sequential rounds or proteins that satisfy the chosen criteria have been generated. There is a plethora of methods for generating an ensemble of mutated genes. Specifically, sequence diversity can be created by random mutagenesis, typically accomplished using error-prone polymerase chain reaction techniques ; by homologous in vitro recombination ; or by nonhomologous recombination. The latter involves two families of methods collectively known as incremental truncation for the creation of hybrid enzymes and sequence-homology independent protein recombination. Regardless of the means for generating sequence diversity, the next and by far the more technically challenging step in directed evolution is the screening of the resulting library of protein-expressing cells to isolate those that are expressing a protein variant that exhibits the desired function. It is fair to say that evolutionary protein design has been hampered by limitations in screening technologies. The quantitative determination of protein function for each and every clone in a library in a high-throughput fashion is a difficult and technically demanding task. In broad terms, there are four general strategies suitable for the screening of combinatorial protein libraries: phage display; biological assays that include selections and assays that use reporter enzymes [e.g., two-hybrid-like techniques for detecting interacting proteins ]; single-well assays using high-density microtiter well plates; and flow cytometry (FC) methods. Each of these methods has a different set of advantages and shortcomings.

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Chen, Charlie L., Peter Strop, Michal Lebl, and Kit S. Lam. "[12] One bead-one compound combinatorial peptide library: Different types of screening." In Combinatorial Chemistry. Elsevier, 1996. http://dx.doi.org/10.1016/s0076-6879(96)67014-1.

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"Key Ingredients for Efficient High-Throughput Screening Lucia Carrano and Stefano Donadio." In Combinatorial Chemistry and Technologies. CRC Press, 2005. http://dx.doi.org/10.1201/9781420027846-15.

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"Structure-Based Combinatorial Library Design and Screening: Application of the Multiple Copy Simultaneous Search Method." In Combinatorial Library Design and Evaluation. CRC Press, 2001. http://dx.doi.org/10.1201/9781482270761-23.

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"Globular Oligonucleotide Screening via the SELEX Process: Aptamers as High-Affinity, High-Specificity Compounds for Drug Development and Proteomic Diagnostics Larry Gold." In Combinatorial Chemistry and Technologies. CRC Press, 2005. http://dx.doi.org/10.1201/9781420027846-24.

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Prabu, S. Lakshmana. "Drug Discovery." In Advances in Medical Technologies and Clinical Practice. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7326-5.ch001.

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Modern chemistry foundations were made in between the 18th and 19th centuries and have been extended in 20th century. R&D towards synthetic chemistry was introduced during the 1960s. Development of new molecular drugs from the herbal plants to synthetic chemistry is the fundamental scientific improvement. About 10-14 years are needed to develop a new molecule with an average cost of more than $800 million. Pharmaceutical industries spend the highest percentage of revenues, but the achievement of desired molecular entities into the market is not increasing proportionately. As a result, an approximate of 0.01% of new molecular entities are approved by the FDA. The highest failure rate is due to inadequate efficacy exhibited in Phase II of the drug discovery and development stage. Innovative technologies such as combinatorial chemistry, DNA sequencing, high-throughput screening, bioinformatics, computational drug design, and computer modeling are now utilized in the drug discovery. These technologies can accelerate the success rates in introducing new molecular entities into the market.

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Priya, Annu, and Sudip Kumar Sahana. "Processor Scheduling in High-Performance Computing (HPC) Environment." In Advances in Library and Information Science. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-4742-7.ch009.

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Processor scheduling is one of the thrust areas in the field of computer science. The future technologies use a huge amount of processing for execution of their tasks like huge games, programming software, and in the field of quantum computing. In real-time, many complex problems are solved by GPU programming. The primary concern of scheduling is to reduce the time complexity and manpower. Several traditional techniques exit for processor scheduling. The performance of traditional techniques is reduced when it comes to the huge processing of tasks. Most scheduling problems are NP-hard in nature. Many of the complex problems are recently solved by GPU programming. GPU scheduling is another complex issue as it runs thousands of threads in parallel and needs to be scheduled efficiently. For such large-scale scheduling problems, the performance of state-of-the-art algorithms is very poor. It is observed that evolutionary and genetic-based algorithms exhibit better performance for large-scale combinatorial and internet of things (IoT) problems.

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Conference papers on the topic "Combinatorial library screening technologies"

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Lei, Du, Yuandi Zhao, Tongsheng Cheng, Shaoqun Zeng, and Qingming Luo. "Self-encoding resin beads of combinatorial library screening." In Biomedical Optics 2003, edited by Dan V. Nicolau and Ramesh Raghavachari. SPIE, 2003. http://dx.doi.org/10.1117/12.477782.

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Brey, Darren M., Bryan S. Margulies, Kurt D. Hankenson, and Jason A. Burdick. "Screening of a Biodegradable Polymer Library for Optimal Scaffolding for Mineralized Tissue Engineering." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206381.

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Combinatorial libraries have been developed recently for identifying large numbers of potentially bioactive compounds or materials for a range of medical applications[1]. While drug companies have been using methods for screening libraries of compounds for therapeutic benefit for years, only recently have libraries been exploited for the generation of scaffolds for regenerative medicine[2–4]. Our lab has developed a library of photocrosslinkable and biodegradable poly(β-amino ester)s (PBAEs)[5] that can be easily tuned for stiffness and degradation for a variety of applications [6]. Here, we s

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Kennedy, Perry C., Marc C. Guilanotti, Travis LsVoi, and Said M. Sebti. "Abstract 2580: Screening of a mixture-based synthetic combinatorial library identifies small molecules that inhibit the ability of GTP to displace mant-GDP from mutant G12D KRas." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2580.

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Huang, Alice H., Nuzhat A. Motlekar, Ashley Stein, Eileen M. Shore, Scott L. Diamond, and Robert L. Mauck. "High-Throughput Screening of Chemical Libraries for Modulators of Mesenchymal Stem Cell Chondrogenesis." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193118.

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Mesenchymal stem cells (MSCs) are a multi-potential cell type that can be induced to differentiate to a variety of tissue-specific cell phenotypes, including cartilage (chondrogenesis) and bone (osteogenesis). Given this multi-potentiality, MSCs are a promising cell source for exploring developmental paradigms and for tissue engineering (TE) applications. For cartilage formation assays, MSCs are collected in high-density pellets and treated with specific biofactors, including TGF-β superfamily members and dexamethasone in a chemically defined medium (CM) [1]. During chondrogenesis, extracellul

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Shiotani, Hiroki, Nariaki Uto, Koichi Kawaguchi, Yoshihiko Shinoda, Kiyoshi Ono, and Takashi Namba. "The Screening Methodologies and/or Achievement Evaluation in Japanese FR Cycle Development Program With the Changing Needs for Evaluation." In 2012 20th International Conference on Nuclear Engineering and the ASME 2012 Power Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icone20-power2012-54933.

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This paper argues the characteristics evaluation of Fast Reactor and fuel cycle concepts in the FS “Feasibility Study on commercialized fast reactor cycle systems” and the achievement of the performance evaluation conducted in FaCT (Fast Reactor Cycle System Technology Development) project in Japan. At the beginning of FS phase-I (JFY1999), a combinatorial number of candidate concepts with innovative technologies were screened. After the FS phase-I evaluation, the several promising FR cycle concepts were selected to achieve consistency between FR system and fuel cycle system. Analytical evalua

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