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Dissertations / Theses on the topic 'Combined drugs'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Phul, Parvinder Singh. "A study into the predictability of the combined effects of mixtures of anticancer drugs." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431083.

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2

Battah, Abdel-Kader Hamdi. "The analysis of drugs and solvents in forensic toxicology by combined GC- and LC-MS." Thesis, University of Glasgow, 1989. http://theses.gla.ac.uk/4115/.

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The work described in this thesis was in the field of Forensic Toxicology, which is the study and practice of toxicology for legal purposes. Three different application areas were considered: (a) the analysis of drugs in blood by gas chromatography-mass spectrometry (GC-MS) following isolation from the biological matrix by solid phase extraction procedures, (b) the analysis of paint solvents in blood by gas chromatography (GC) and GC-MS following dynamic headspace elution from blood, and (c) an evaluation of Thermospray/Plasmaspray (TSP/PSP LC-MS) liquid chromatography-mass spectrometry as the

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3

Tamm, Leanne. "Single and combined effects of stimulant medication and contingencies on the cognitive performance of children with attention deficit hyperactivity disorder /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004383.

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4

CHIAVETTA, Roberta. "Study of the combined effects of CDK1 inhibitors and senolytic drugs for the clearance of aneuploid-senescent cells." Doctoral thesis, Università degli Studi di Palermo, 2022. http://hdl.handle.net/10447/533837.

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Despite the progresses in discovering new therapeutic drugs and treatments, cancer is still one of the main causes of death. The biggest part of available treatments, moreover, is not always effective against tumour spread and it also has negative effects on the healthy tissues of the individual. For this reason, it is extremely relevant to find new strategies to avoid side effects during the anti-cancer therapies. Aneuploidy, an aberrant number of chromosomes in the cell, is a typical condition of cancer cells caused mainly by segregation errors and chromosomal instability (CIN). CIN is a pro

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5

Jackson, P. J. "Investigations of supercritical fluid chromatography, supercritical fluid extraction and capillary electrophoresis combined with mass spectrometry for the analysis of drugs of forensic interest." Thesis, Swansea University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637384.

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The major objective of these investigations was to develop a total assay for quantifying drugs of forensic interest in biological fluids that have presented problems with more conventional procedures. Supercritical fluid techniques in combination with mass spectrometry provided the main basis of the studies reported in this thesis. The practical aspects of the combination of supercritical fluid techniques with mass spectrometry was also investigated with a view to increasing sensitivity and specificity. Chapter 1 provides an overview of basic chromatographic techniques such as gas chromatograp

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6

Amin, Muhammad Umair [Verfasser], and Udo [Akademischer Betreuer] Bakowsky. "Development of novel combined nano delivery system to improve cellular uptake of weakly basic anticancer drugs and cell imaging / Muhammad Umair Amin ; Betreuer: Udo Bakowsky." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1223130142/34.

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7

Kretzer, Iara Fabricia. "Terapia antitumoral combinada de derivados do paclitaxel e etoposídeo associados à nanoemulsão lipídica rica em colesterol - LDE." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25092009-165543/.

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A LDE é uma nanoemulsão rica em colesterol com composição semelhante às lipoproteínas naturais. Devido a sua capacidade de ligação aos receptores da lipoproteína de baixa densidade (LDL) cuja expressão é aumentada em células neoplásicas, a LDE pode ser usada como veículo de agentes quimioterápicos concentrando os mesmos no tecido tumoral. A base racional da quimioterapia combinada é utilizar medicamentos que atuem em diferentes partes dos processos metabólicos da célula, aumentando dessa forma a probabilidade de destruição de uma maior quantidade de células tumorais. O principal fator limitant

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8

Ritzmo, Carina. "Drug administration and blood sampling for pharmacokinetic studies in pediatric cancer patients." Stockholm : Department of Women's and Children's health, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-672-9/.

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9

Li, Bing. "Drug solubility studies by using combined solubilization techniques." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/284037.

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This study focuses on the development of mathematical models that explain and predict the combined effects of pH control and complexants (cyclodextrin), pH control and surfactants, as well as pH control and cosolvents on the total solubility of the drug. The total solubility of the drug is expressed as the sum of the concentrations of individual species. In complexant-water and surfactant-water systems free unionized drug [Dᵤ] and free ionized drug [Dᵢ] are present along with either complexed unionized drug [DᵤL] and complexed ionized drug [DᵢL], or micellar unionized drug [DᵤM] and micellar i

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10

Yan, Fusheng [Verfasser]. "A thermo-responsive drug release system for combined chemohyperthermia / Fusheng Yan." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1075757681/34.

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11

Kashkary, Loay M. T. "Development of a combined DNA and drug extraction methodology for forensic toxicology application." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:11661.

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Biological samples recovered at crime scenes may contain unsuspected and valuable evidence, such as illicit drugs, in addition to nucleic acids. Deoxyribonucleic acid (DNA) analysis provides valuable information to identify a suspect or victim, as well as to exclude an innocent individual as the perpetrator of a crime. Identification of drugs can also be very informative for forensic investigation to determine whether a perpetrator committed a crime under the influence of illicit substances. In the field of forensic analysis, sample preparation for identifying both DNA and drugs of abuse repre

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12

Petersson, Karsten. "Combined formulations based on prodrugs and in situ gelling systems : design and pharmaceutical chemical characterisation /." [Cph.] : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics, 2004. http://www.dfh.dk/phd/defences/karstenpetersson.htm.

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13

Chen, W. "Combined use of capillary electrophoresis and X-ray crystallography in fragment-based drug discovery." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1410604/.

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The effectiveness of combined use of capillary electrophoresis (CE) and X-ray crystallography in fragment-based drug discovery has been investigated. Using Heat Shock Protein 90α (Hsp90α) as a test system, CE fragment hits were validated by X-ray crystallography with the added benefit of structural information. The crystal structure of one of the fragment hits in complex with Hsp90α ATPase domain has shown that even weakly binding fragments can cause conformational change of macromolecules upon binding. Another investigation was focused on identifying stabilisers of the tetrameric plasma prote

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14

Landstedt-Hallin, Lena. "Combined sulphonylurea and insulin treatment for type 2 diabetes mellitus : metabolic and electrophysiological studies /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4048-7/.

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15

Patel, Ravi Bhasker. "DEVELOPMENT OF A NOVEL COMBINED EXPERIMENTAL AND MODELING APPROACH TO CHARACTERIZE IN SITU FORMING IMPLANTS FOR INTRATUMORAL DRUG DELIVERY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1303727407.

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16

Fugit, Kyle Daniel. "QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/37.

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Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal rel

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17

McGregor, Lynn Marie. "Methods for the Identification of Ligand-Target Pairs from Combined Libraries of Targes and Ligands." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11370.

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Advances in genome and proteome research have led to a dramatic increase in the number of macromolecular targets of interest to the life sciences. A solution-phase method to simultaneously reveal all ligand-target binding pairs from a single solution containing libraries of ligands and targets could significantly increase the efficiency and effectiveness of target-oriented screening efforts. Here, we describe interaction-dependent PCR (IDPCR), a solution-phase method to identify binding partners from combined libraries of small-molecule ligands and targets in a single experiment. Binding betwe

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18

LAFIANDRA, MIRIAM. "HADRON AND PHOTON IRRADIATION COMBINED WITH A CHEMOTHERAPY DRUG: AN IN VITRO STUDY IN HUMAN CANCER CELLS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/515674.

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Nowadays combined therapies exploiting chemotherapy agents and radiation used in conjunction attract a lot of interest, especially when dealing with radio-resistant tumors. In fact, it is known that some drugs have radio-sensitizing effects, for example inhibiting DNA repair mechanisms. The aim of these combined therapies is to obtain better tumor local control and to reduce the risk of distant failures. Many studies with different kind of chemical agents used in combination with photon beams have been performed for different cancers, but at the moment few data about the use of chemicals co

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19

Rodríguez, Amigo Beatriz. "Light-sensitive nanocarriers for drug delivery in photodynamic therapy." Doctoral thesis, Universitat Ramon Llull, 2018. http://hdl.handle.net/10803/462210.

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Aquesta tesi aprofundeix en l’estudi de nanotransportadors com a sistemes de vehiculització i en alguns casos, alliberació de fotosensibilitzadors emprats en teràpia fotodinàmica. S’han fet servir dos nanotransportadors de naturalesa diferent: proteïnes i liposomes. En primer lloc s’ha investigat els complexos formats entre la hipericina i les proteïnes apomioglobina i β-lactoglobulina. S’han estudiat les característiques fisicoquímiques i fotofísiques, avaluant l’activitat antimicrobiana en front a bacteris gram-positius i gram-negatius. En ambdues matrius proteiques el fotosensibilitzador e

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20

Nguyen, Tue Gia Women's &amp Children's Health Faculty of Medicine UNSW. "Combined transcription modulating agents to overcome MycN-mediated retinoid reistance in hish risk neuroblastoma." Publisher:University of New South Wales. Women's & Children's Health, 2007. http://handle.unsw.edu.au/1959.4/44285.

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Neuroblastoma (NB) is the most common solid tumor of early infancy. Despite a significant improvement in the general survival rate for children with cancer, the prognosis of high-risk NB remains low, at about 30%, despite the use of intensive chemo-radiotherapy followed by differentiation therapy with retinoic acid (RA). Relapses in this category of NB are often due to the emergence of multi-drug and RA-resistant minimal residual cancer cells. The use of natural 13-cis RA, as a single chemo-preventive agent, has improved the survival rate to 50% for high-risk NB patients. However, the prevalen

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21

Silveira, Maria Irismar da Silva. "Perfil laboratorial bioquÃmico e hematolÃgico de uma populaÃÃo de pacientes diagnosticados com hansenÃase: antes e durante a poliquimioterapia." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1073.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A HansenÃase Ã uma doenÃa infecciosa, de evoluÃÃo lenta, transmitida pelo Mycobacterium leprae que acomete nervos e pele. O tratamento especÃfico das pessoas portadoras de hansenÃase foi enfatizado no inÃcio dos anos 80 pela OrganizaÃÃo Mundial de SaÃde (OMS) com o objetivo de curar o indivÃduo da infecÃÃo pelo Mycobacterium leprae e evitar o desenvolvimento de incapacidades. A OMS implementou a poliquimioterapia (PQT) composta pelas drogas dapsona, clofazimina e rifampicina, cuja associaÃÃo evita a resistÃncia medicamentosa do bac

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22

Dabbas, Basel. "Combined effects of vitamin D receptor agonists and histone deacetylase inhibition on vitamin D-resistant squamous carcinoma cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112395.

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The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), is a key calcium (Ca++) regulatory hormone. It is also associated with functions unrelated to Ca++ homeostasis. Here, special attention is paid towards the anticancer properties of 1,25D. 1,25D strongly inhibits the growth of well-differentiated head and neck squamous cell carcinoma (HNSCC) derived cell lines. However, advanced, less differentiated, HNSCC cell lines (e.g. SCC4) are partially resistant to 1,25D. Resistance to nuclear receptor (NR) agonists is a common event that occurs in other NR-related treatments. For example, s

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23

Bassat, Orellana Quique. "Malaria in the paediatric wards of a rural Mozambican hospital and the clinical development of new antimalarial drugs." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/2272.

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Despite a renewed impetus on bringing together efforts to wipe malaria from the globe, the truth is that this ancient disease remains one of the principal threats to child survival in vast areas of the world. The existing control measures are largely insufficient to reduce globally the malaria burden, and as of today, malaria remains endemic in more than 100 countries, where at least half of the world's population live exposed to the risk of being infected. Indeed, the burden of malaria morbidity and mortality continues to be unacceptably high, with more than 250 million clinical episodes and

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24

Sadou, Yaye Hassane. "Etude du cycle de vie du Ticagrelor par une approche combinée prédictive et caractérisation structurale." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS024/document.

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Les scandales sanitaires ayant émaillé le médicament ont mis la sécurité d’utilisation au cœur des préoccupations des acteurs de santé. Tout au long de son cycle de vie, le médicament est susceptible d’exposition à des conditions de stress pouvant conduire à sa dégradation et potentiellement, à la modification du rapport bénéfice/risque. Ce problème est d’autant plus marqué en milieu hospitalier où les médicaments en post – AMM sont manipulés pour des besoins spécifiques des patients. Quid de la maîtrise des modifications de leurs microenvironnements ? Etendre son espace de connaissances est a

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25

Löfgren, Christina. "Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-183-0/.

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26

Patel, Ravi. "DEVELOPMENT OF A NOVEL COMBINED EXPERIMENTAL AND MODELING APPROACH TO CHARACTERIZE IN SITU FORMING IMPLANTS FOR INTRATUMORAL DRUG DELIVERY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1297846540.

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27

Dubbelboer, Ilse R. "Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330953.

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There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). In the microparticular system DEBDOX, DOX is loaded into the drug-eluting entity DC Bead™. The overall aim of the thesis was to improve pharmaceutical understanding of the LIPDOX and DEBDOX formulations, in order to facilitate the future development of novel drug delivery systems. In vivo re

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28

Rieker, Marcel. "Targeted Combination Therapy: Discovery and Evaluation of Synergistic Anticancer Effects of Anti-HER2-Duocarmycin Antibody-Drug Conjugates Combined with ATR Inhibitors." Phd thesis, Shaker Verlag GmbH, 2020. https://tuprints.ulb.tu-darmstadt.de/8615/7/2019-06-13_PhD_thesis_Rieker.pdf.

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While the global cancer burden is still high with 10 million people being diagnosed with cancer and 6 million cancer-related deaths yearly, academia and industry are developing more and more sophisticated therapies to combat cancer. One recent development are antibody-drug conjugates (ADCs) which consist of an antibody portion that mediates tumor selectivity and a highly cytotoxic drug designed to efficiently kill cancer cells. The majority of ADCs in clinical trials today carries payloads targeting the cytoskeleton. However, microtubule-targeting agents often lack clinical efficacy and thus,

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Rieker, Marcel [Verfasser]. "Targeted Combination Therapy: Discovery and Evaluation of Synergistic Anticancer Effects of Anti-HER2-Duocarmycin Antibody-Drug Conjugates Combined with ATR Inhibitors / Marcel Rieker." Düren : Shaker, 2019. http://d-nb.info/1198600004/34.

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30

Goldflam, Michael. "Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123711.

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The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or biochemical tools.The use of biologics to target protein-protein interfaces is relatively advanced; suffer although from some intrinsic drawbacks as the danger of immunogenicity, the inability to cross biological barriers efficiently and high production costs. Small molecule inhibitors do not necessarily share these drawbacks. Unfortunately the druggability of protein-protein int

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31

Vinciguerra, Daniele. "Drug-initiated synthesis and biological evaluation of heterotelechelic polymer prodrug nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS592.

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Une méthodologie générale et efficace pour la synthèse de nanoparticules de prodrogues polymères hétérotéléchéliques à hauts taux de charge a été mise au point en combinant d’une part la méthode dite du “principe actif amorceur” pour obtenir des prodrogues polymères α-fonctionnelles par polymérisation radicalaire contrôlée par les nitroxydes (NMP), et d’autre part la réaction d'échange de nitroxyde à partir d’un nitroxyde fonctionnel pour coupler une seconde molécule d'intérêt en bout de chaîne. Une petite bibliothèque de prodrogues polymères hétérotéléchéliques avec différentes combinaisons p

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Rodríguez, Escalona Gabriela de Jesús. "DEVELOPMENT OF CONTROLLED DRUG DELIVERY SYSTEMS OF POLYMERIC NANOMEDICINES ASSOCIATED TO SCAFFOLDS FOR TISSUE REGENERATION." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/63231.

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[EN] Nowadays, one of the biggest concerns that permanently keep the attention of main important sectors of human society is health. Modern medical science is compromised with not only providing good adequate treatments but also effective specific solutions for each type of disease or human pathology. In this direction, innovative approaches like tissue engineering or regenerative medicine, controlled drug delivery systems and nanomedicines emerge to bring alternatives to situations hard to solve with conventional treatment and strategies, including the replacement of damaged or diseases tissu

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33

Tjioe, Kellen Cristine. "Reposicionamento de fármacos no câncer de boca: Identificação de possíveis agentes." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-03022016-142055/.

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Objetivos: O objetivo deste estudo foi o de identificar compostos seletivamente tóxicos ao carcinoma espinocelular de boca in vitro por meio do reposicionamento de fármacos. Material e Métodos: Por meio de um escaneamento baseado na viabilidade celular de 1.280 fármacos, nós selecionamos três princípios ativos (luteolin, metixene hydrochloride e nitazoxanide) letais às células de câncer de boca SCC-25 e pouco tóxicos às células de queratinócitos cutâneos imortalizados HaCaT. Os fármacos candidatos foram investigados quanto à sua dose- e tempo-resposta bem como comparados e combinados à agentes

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34

Kretzer, Iara Fabricia. "Uso combinado de sinvastatina e paclitaxel associado à nanoemulsão lipídica no tratamento do câncer." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-18052017-121244/.

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Uma nova alternativa para o tratamento do câncer foi proposta em estudos anteriores, consistindo no uso de uma nanoemulsão lipídica como transportadora de agentes quimioterápicos às células neoplásicas. A redução da toxicidade da quimioterapia promovida pelo direcionamento específico de quimioterápicos às células tumorais nos levou a testar o potencial de aplicação do sistema de nanopartículas lipídicas na terapêutica combinada do paclitaxel com a sinvastatina, um agente hipolipemiante que pode ser empregado como coadjuvante no tratamento do câncer. Nos dias 11, 14 e 19 após a inoculação de cé

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Herchenhorn, Daniel. "Estudo de fase I/II de Erlotinib (OZI-774) combinado com radioterapia e cisplatina em pacientes com carcinoma epidermóide de cabeça e pescoço, localmente avançado." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-23022010-170624/.

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Propósito: Erlotinib, um inibidor oral da Tirosina Quinase posicionada junto ao domínio intracelular do EGFR, é uma droga ativa contra Carcinoma de Células Escamosas de Cabeça e Pescoço (CECCP) avançado e possivelmente possui sinergismo com a quimioterapia e radioterapia. O objetivo deste trabalho foi avaliar a dose adequada, a segurança e eficácia do Erlotinib associado à combinação padrão de quimioterapia e radioterapia no CECCP localmente avançado. Pacientes e Métodos: Pacientes com CECCP localmente avançado são o fundamento deste ensaio clínico de FaseI/II, cujo tratamento consistiu da com

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Rieker, Marcel [Verfasser], Harald [Akademischer Betreuer] Kolmar, and Felix [Akademischer Betreuer] Hausch. "Targeted Combination Therapy: Discovery and Evaluation of Synergistic Anticancer Effects of Anti-HER2-Duocarmycin Antibody-Drug Conjugates Combined with ATR Inhibitors / Marcel Rieker ; Harald Kolmar, Felix Hausch." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1202922872/34.

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Lavor, Edilene Pereira. "Estudo de pr?-formula??o para dose fixa combinada dos tuberculost?ticos rifampicina, isoniazida, pirazinamida e etambutol (4 em 1)." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13458.

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Made available in DSpace on 2014-12-17T14:16:26Z (GMT). No. of bitstreams: 1 EdilenePL_DISSERT.pdf: 1151865 bytes, checksum: 7a412187753da50d4030404745c567f7 (MD5) Previous issue date: 2010-02-26<br>According to the global framework regarding new cases of tuberculosis, Brazil appears at the 18th place. Thus, the Ministry of Health has defined this disease as a priority in the governmental policies. As a consequence, studies concerning treatment and prevention have increased. Fixed-dose combination formulations (FDC) are recognized as beneficial and are recommended by WHO, but they present in

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Dubois, Clémence. "Optimisation du traitement du cancer du sein Triple-Négatif : développement des modèles de culture cellulaire en trois dimensions, efficacité de l'Olaparib (anti-PARP1) en combinaison avec la radiothérapie et chimiorésistance instaurée par les protéines Multi Drug Résistance." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAS018/document.

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Le cancer du sein est une maladie complexe et difficile à caractériser. Parmi les différents sous-types moléculaires, les tumeurs du sein Triple-Négatives (TN) sont particulièrement agressives et de mauvais pronostic. Elles sont caractérisées par une absence d’expression des récepteurs aux œstrogènes (ER), à la progestérone (PR), l’absence de surexpression du récepteur Human Epidermal growth factor 2 (HER2) et de fréquentes mutations sur les gènes BRCA1/2 (profil « BRCAness »). En absence de thérapies ciblées efficaces, de nombreux traitements ciblés notamment les inhibiteurs de poly-ADP-ribos

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Ferreira, Anna Carolina Galvão. "Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tede/4152.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-02-13T20:15:11Z No. of bitstreams: 2 Dissertação - Anna Carolina Galvão Ferreira - 2012.pdf: 1738587 bytes, checksum: b4a75ebc8af8f8a234573009292ed508 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-02-13T20:16:17Z (GMT) No. of bitstreams: 2 Dissertação - Anna Carolina Galvão Ferreira - 2012.pdf: 1738587 bytes, checksum: b4a75ebc8af8f8a234573009292ed508 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7

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van, Oosten Luuk Nico [Verfasser], and Christian D. [Akademischer Betreuer] Klein. "A novel high-throughput and label-free phenotypic drug screening approach: MALDI-TOF mass spectrometry combined with machine learning strategies / Luuk Nico van Oosten ; Betreuer: Christian D. Klein." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1211820904/34.

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Marfia, G. "ACQUIRED ALTERATIONS OF SPHINGOSINE-1-PHOSPHATE METABOLISM CONFER STEMNESS AND DRUG RESISTANCE PROPERTIES ON GLIOBLASTOMA MULTIFORME: A NEW POTENTIAL TARGET FOR A COMBINED APPROACH TO TREAT BRAIN CANCER." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/333056.

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The eradication of glioblastoma multiforme (GBM) (WHO grade 4) remains a tremendous clinical challenge in human oncology. Indeed, this tumor accounts for the most common, aggressive and lethal primary brain cancer in adults, exhibiting a dismal prognosis, despite extensive surgical resection and adjuvant radio- and chemo-therapy. The finding that GBM contains functional subsets of cells with stem-like properties named glioblastoma stem cells (GSCs) has opened up novel opportunities and promises for the development of new therapies for this devastating cancer. GSCs are self-renewing, multipoten

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Kandalam, Saikrishna. "Pharmacologically active microcarriers delivering brainderived neurotrophic factor combined to adult mesenchymal stem cells : novel approach for the treatment of spinal cord injury." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0050/document.

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Un traumatisme de la moelle épinière (TME) est une condition dévastatrice entraînant la perte permanente de fonctions neuronales. L’objectif de cette thèse est de formuler de microsupports pharmacologiquement actif (MPAs) avec une surface de fibronectine (FN), libérant le« brain-derived neurotrophic factor » (BDNF) de façon controlée. Nous voulons combiner ce système avec des cellules souches mésenchymateuses (CSMs) pour la réparation de TME. Le BDNF nanoprécipité a été encapsulé dans les FN-MPAs et le profil de libération in vitro a été évaluée. Elle a montré une libération biphasique et prol

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Charignon, Elsa. "Évaluation de nouveaux complexes halogénés de Platine liés à des carbènes N-hétérocycliques pouvant combiner un effet chimiotoxique et radiotoxique pour le traitement du mélanome cutané métastatique." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1207.

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Bien qu'il concerne que 10% des cancers de la peau, le mélanome cutané est à l'origine de 80% de la mortalité due à ce type de cancer. L'objectif de mon travail de thèse était de mesurer l'efficacité cytotoxique de nouveaux complexes de platine (les NHC-Pt) dans le mélanome cutané métastatique, mais également de décrire leurs mécanismes d'action. Ces complexes pouvant être radiomarqués, nous avons vérifié l'hypothèse selon laquelle les propriétés chimiotoxiques du platine peuvent être combinées aux propriétés radiotoxiques d'électrons de faible énergie émis par l'iode 123. Enfin, ce radiomarqu

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Fan, Yannan. "Tissue-specific gain of wild-type RTK levels combined with screen strategies identify new mechanisms of cell vulnerability in developmental and tumorigenic programs." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4071.

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Pour étudier la capacité cellulaire à s’adapter aux changements de signalisation dépendante des RTKs, nous utilisons un modèle de souris où l’expression du RTK Met sauvage peut être accrue dans un tissu spécifique. La plupart des tissus se protègent contre cette expression anormale des RTK. Mais certains types cellulaires sont sensibles aux altérations des RTKs, c’est le cas du mésenchyme du membre pendant l’embryogenèse. En effet, l’expression de certains gènes du mésenchyme est modifiée et celui-ci n’est plus accessible aux myoblastes qui le colonisent, conduisant à des déficits des muscles

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Vančurová, Markéta. "Trendy ve spotřebě kombinované hormonální kontracepce za období 2007-2011." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-135927.

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This thesis describes a methodology for expressing the consumption of drugs, a system of ATC/DDD, ATC classification and DDD recommended daily dose assigment. It also describes the data source which are relevant for this expression. In this thesis I will focuse on combined oral contraception and its consumption which I will express in DDD/1000inhab/day, number of packages and in financial expression in czech krones. At the end of this thesis I will evaluate the results of the consumption according State institute for drug control and my own survey.

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Moore, Nathan F. "Slow-Cycling Cancer Cells: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/620.

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Tumor recurrence after chemotherapy is a major cause of patient morbidity and mortality. Recurrences are thought to be due to small subsets of stem-like cancer cells that are able to survive chemotherapy and drive tumor re-growth. A more complete understanding of stem-like cancer cell regulation is required to develop therapies to better target and eliminate these cells. Slow-cycling stem cells are integral components of adult epithelial tissues and may give rise to cancer stem cell populations that share similar characteristics. These slow-cycling adult stem cells are inherently resistant to

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Oqueka, Tim [Verfasser], and Bernhard [Akademischer Betreuer] Fleischer. "Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia / Tim Oqueka. Betreuer: Bernhard Fleischer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1030364990/34.

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Teixeira, Jane de Oliveira Gonzaga [UNIFESP]. "Infecção da corrente sanguínea causada por Pseudomonas aeruginosa resistente aos carbapenêmicos: fatores associados a mortalidade e influência da terapia combinada com polimixina B e imipenem." Universidade Federal de São Paulo (UNIFESP), 2011. http://repositorio.unifesp.br/handle/11600/9742.

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Made available in DSpace on 2015-07-22T20:50:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-27<br>P. aeruginosa é um importante microorganismo em infecções de corrente sanguínea. O tratamento da P. aeruginosa resistente aos carbapenêmicos é um desafio, já que as drogas mais utilizadas para este fim, as polimixinas, tem uma ação inferior aos carbapenêmicos. No entanto, o uso combinado de polimixinas com carbapenêmicos tem demonstrado sinergismo em estudos in vitro. Objetivos: Avaliar a resposta ao tratamento com polimixina B versus polimixina B e imipenem em pacientes com infec

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COSTA, Dalva Aparecida Marques da. "A experiência da adesão ao tratamento pela mulher com HIV/aids." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/692.

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Made available in DSpace on 2014-07-29T15:04:27Z (GMT). No. of bitstreams: 1 dissertacao-dalva-aparecida.pdf: 328745 bytes, checksum: 4af67ad606d4d4ef8515b6d4cc3d79eb (MD5) Previous issue date: 2008-03-24<br>The high effectiveness of the combined antiretroviral therapy for HIV/AIDS is wellknown, but it depends on the efficient adhesion of the patient to the treatment. The efficient adhesion to the treatment guarantees its effectiveness because increasing the patient s adherence to the antiretroviral treatment constitutes a global goal to stop the HIV/AIDS epidemic. This study aimed to unders

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Botteselle, Giancarlo di Vaccari. "Síntese de 2-aril e 2,5-diarilfuranos funcionalizados: potenciais sondas fluorescentes." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-18092009-153237/.

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A utilização de sondas fluorescentes para marcação ou detecção de biomoléculas de interesse em processos biológicos distintos, vem recebendo grande atenção em pesquisas biomédicas, de análises clínicas e biologia celular. Em geral, estas sondas fluorescentes são constituídas por moléculas orgânicas pequenas, as quais apresentam características fluorescentes e capacidade de conjugar-se com estas biomoléculas. Desta forma, esta dissertação descreve inicialmente a síntese de compostos 2-aril ou 2,5- diarilfuranos e tiofenos (3, 5, 7 e 9a-i), a partir de espécies orgânicas de telúrio (1, 4, 6 e 8)

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