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Journal articles on the topic 'Combretum caffrum'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Pettit, George R., Gordon M. Cragg, and Sheo Bux Singh. "Antineoplastic Agents, 122. Constituents of Combretum caffrum." Journal of Natural Products 50, no. 3 (1987): 386–91. http://dx.doi.org/10.1021/np50051a008.

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2

Tripodi, Farida, Federico Dapiaggi, Fulvia Orsini, Roberto Pagliarin, Guido Sello, and Paola Coccetti. "Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents." MedChemComm 9, no. 5 (2018): 843–52. http://dx.doi.org/10.1039/c8md00147b.

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Several synthetic combretastatin A4 (CA-4) derivatives were recently prepared to increase the drug efficacy and stability of the natural product isolated from the South African tree Combretum caffrum.

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3

Pettit, George R., Sheo Bux Singh, Margaret L. Niven, and Jean M. Schmidt. "Cell growth inhibitory dihydrophenanthrene and phenanthrene constituents of the african tree Combretum caffrum." Canadian Journal of Chemistry 66, no. 3 (1988): 406–13. http://dx.doi.org/10.1139/v88-071.

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Combretum caffrum, a tree in the family Combretaceae, has been found to contain three 9,10-dihydrophenanthrenes (6,7-dihydroxy-2,3,4-trimethoxy; 7-hydroxy-2,3,4,6-tetramethoxy; and 2,7-dihydroxy-3,4,6-trimethoxy) that inhibit (ED50 2.2, 2.8, and 2.6 μg/mL) growth of the murine lymphocytic leukemia cell line. One phenanthrene (7-hydroxy-2,3,4,6-tetramethoxy) was also isolated with similar (ED50 2.0 μg/mL) activity. Structures for each of these substances, including a dihydrophenanthrene (2-hydroxy-3,4,6,7-tetramethoxy-9,10-dihydrophenanthrene), were determined by detailed high resolution nuclea

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4

Lawrence, Nicholas J. "The Synthesis of (E) and (Z)-Combretastatins A-4 and a Phenanthrene from Combretum caffrum." Synthesis 1999, no. 09 (1999): 1656–60. http://dx.doi.org/10.1055/s-1999-3570.

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5

Pettit, George R., Sheo Bux Singh, Jean M. Schmidt, Margaret L. Nixen, Ernest Hamel, and Chii M. Lin. "Isolation, Structure, Synthesis, and Antimitotic Properties of Combretastatins B-3 and B-4 from Combretum caffrum." Journal of Natural Products 51, no. 3 (1988): 517–27. http://dx.doi.org/10.1021/np50057a011.

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6

Pettit, George R., Sheo Bux Singh, and Margaret L. Niven. "Antineoplastic agents. 160. Isolation and structure of combretastatin D-1: a cell growth inhibitory macrocyclic lactone from Combretum caffrum." Journal of the American Chemical Society 110, no. 25 (1988): 8539–40. http://dx.doi.org/10.1021/ja00233a037.

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7

El-Zayat, A. Atef Ebrahim, Donna Degen, Sonya Drabek, Gary M. Clark, George R. Pettit, and Daniel D. Von Hoff. "In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub)." Anti-Cancer Drugs 4, no. 1 (1993): 19–25. http://dx.doi.org/10.1097/00001813-199302000-00002.

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8

Karatoprak, Gökçe Şeker, Esra Küpeli Akkol, Yasin Genç, Hilal Bardakcı, Çiğdem Yücel, and Eduardo Sobarzo-Sánchez. "Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications." Molecules 25, no. 11 (2020): 2560. http://dx.doi.org/10.3390/molecules25112560.

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Combretastatins are a class of closely related stilbenes (combretastatins A), dihydrostilbenes (combretastatins B), phenanthrenes (combretastatins C) and macrocyclic lactones (combretastatins D) found in the bark of Combretum caffrum (Eckl. & Zeyh.) Kuntze, commonly known as the South African bush willow. Some of the compounds in this series have been shown to be among the most potent antitubulin agents known. Due to their structural simplicity many analogs have also been synthesized. Combretastatin A4 phosphate is the most frequently tested compounds in preclinical and clinical trials. It

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9

Pettit, George R., Sheo Bux Singh, Margaret L. Niven, Ernest Hamel, and Jean M. Schmidt. "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum." Journal of Natural Products 50, no. 1 (1987): 119–31. http://dx.doi.org/10.1021/np50049a016.

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10

Faustino, Célia, Ana P. Francisco, Vera M. S. Isca, and Noélia Duarte. "Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy." Current Pharmaceutical Design 24, no. 36 (2019): 4270–311. http://dx.doi.org/10.2174/1381612825666190111123959.

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The growing incidence of cancer, the toxic side-effects associated with conventional chemotherapeutic agents and the development of multidrug resistance (MDR) drive the search for novel and more effective drugs with multi-target activity and selectivity towards cancer cells. Stilbenes are a group of naturally occurring phenolic compounds of plant origin derived from the phenylpropanoid pathway that may exist as cis- or trans-isomers. Although the trans-isomer is the more common and stable configuration, resveratrol being a representative compound, cis-stilbenes are potent cytotoxic agents that

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11

Chauhan, Aman, Susanne M. Arnold, Jianrong Wu, et al. "Clinical efficacy and toxicity data on phase I study of fosbretabulin in combination with everolimus in neuroendocrine tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 4114. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4114.

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4114 Background: Fosbretabulin, a synthetic, water-soluble, phosphorylated prodrug of the natural product combretastatin A4 (CA4P), initially isolated from the bark of the South African bush willow, Combretum caffrum, is the lead compound in a class of agents termed vascular disrupting agents (VDAs). Everolimus, an mTOR inhibitor, is FDA approved for the management of well-differentiated NETs. A Phase I trial combining fosbretabulin and everolimus to determine the recommended Phase II trial dose (RP2D), safety data and early clinical efficacy in metastatic GEPNET patients was conducted. Method

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12

Zong, Hongliang, Narsimha Reddy Penthala, Siddhartha Sen, et al. "The Acrylonitrile Analog, VJ-289 Ablates Acute Myelogenous Leukemia Blast, Progenitor and Stem Cell Populations by Inducing Tubulin Acetylation and Caspase Activation." Blood 118, no. 21 (2011): 2496. http://dx.doi.org/10.1182/blood.v118.21.2496.2496.

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Abstract Abstract 2496 Combretastatin A-4, a derivative of combretastatin, a natural product of the South African tree Combretum caffrum, has been reported to have anti-angiogenic and anti-tubulin effects in different cancer cell lines. We synthesized 48 novel combretastatin analogs to assess anti-leukemia activity in a panel of 12 leukemia cell lines. We identified an analog, VJ-289 [(Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile] with robust anti-leukemic activity. VJ-289 showed a dose-dependent toxicity to most of the leukemic cell lines tested. The average LD50 for the 12 di

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13

Crous, P. W., D. A. Cowan, G. Maggs-Kölling, et al. "Fungal Planet description sheets: 1112–1181." Persoonia - Molecular Phylogeny and Evolution of Fungi 45, no. 1 (2020): 251–409. http://dx.doi.org/10.3767/persoonia.2020.45.10.

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Novel species of fungi described in this study include those from various countries as follows: Australia, Austroboletus asper on soil, Cylindromonium alloxyli on leaves of Alloxylon pinnatum, Davidhawksworthia quintiniae on leaves of Quintinia sieberi, Exophiala prostantherae on leaves of Prostanthera sp., Lactifluus lactiglaucus on soil, Linteromyces quintiniae (incl. Linteromyces gen. nov.) on leaves of Quintinia sieberi, Lophotrichus medusoides from stem tissue of Citrus garrawayi, Mycena pulchra on soil, Neocalonectria tristaniopsidis (incl. Neocalonectria gen. nov.)and Xyladictyochaeta t

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14

Fatokun, Kayode, Richard P. Beckett, Boby Varghese, and Norman W. Pammenter. "Cathodic Water Enhances Seedling Emergence and Growth of Controlled Deteriorated Orthodox Seeds." Plants 10, no. 6 (2021): 1170. http://dx.doi.org/10.3390/plants10061170.

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All orthodox seeds eventually deteriorate during storage, a well-known problem in seed banking. Here we used a greenhouse study to test if priming deteriorated seeds with cathodic water can improve the emergence and subsequent seedling growth of three South African tree species, Bolusanthus speciosus, Combretum erythrophyllum and Erythrina caffra. Other priming solutions investigated were calcium magnesium (CaMg) solution and deionized water. In the present study, seeds were subjected to an artificial deterioration by increasing their water content to 14% and keeping them at 40 °C and 100% RH

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15

PETTIT, G. R., S. B. SINGH, M. L. NIVEN, and J. M. SCHMIDT. "ChemInform Abstract: Antineoplastic Agents. Part 129. Cell Growth Inhibitory Dihydrophenanthrene and Phenanthrene Constituents of the African Tree Combretum caffrum." ChemInform 19, no. 35 (1988). http://dx.doi.org/10.1002/chin.198835308.

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16

PETTIT, G. R., S. B. SINGH, and M. L. NIVEN. "ChemInform Abstract: Antineoplastic Agents. Part 160. Isolation and Structure of Combretastatin D-1 (I): A Cell Growth Inhibitory Macrocyclic Lactone from Combretum caffrum." ChemInform 20, no. 12 (1989). http://dx.doi.org/10.1002/chin.198912313.

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17

Mostert, Theo H. C., George J. Bredenkamp, Hannes L. Klopper, Cornie Verwey, Rachel E. Mostert, and Norbert Hahn. "Major Vegetation Types of the Soutpansberg Conservancy and the Blouberg Nature Reserve, South Africa." Koedoe 50, no. 1 (2008). http://dx.doi.org/10.4102/koedoe.v50i1.125.

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The Major Megetation Types (MVT) and plant communities of the Soutpansberg Centre of Endemism are described in detail, with special reference to the Soutpansberg Conservancy and the Blouberg Nature Reserve. Phytosociological data from 442 sample plots were ordinated using a DEtrended CORrespondence ANAlysis (DECORANA) and classified using TWo-Way INdicator SPecies ANalysis (TWINSPAN). The resulting classification was further refined with table-sorting procedures based on the Braun–Blanquet floristic–sociological approach of vegetation classification using MEGATAB. Eight MVT’s were identified a

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18

Crous, P. W., D. A. Cowan, G. Maggs-Kölling, et al. "Fungal Planet description sheets: 1182–1283." Persoonia - Molecular Phylogeny and Evolution of Fungi, 2021. http://dx.doi.org/10.3767/persoonia.2021.46.11.

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Novel species of fungi described in this study include those from various countries as follows: Algeria, Phaeoacremonium adelophialidum from Vitis vinifera. Antarctica, Comoclathris antarctica from soil. Australia, Coniochaeta salicifolia as endophyte from healthy leaves of Geijera salicifolia, Eremothecium peggii in fruit of Citrus australis, Microdochium ratticaudae from stem of Sporobolus natalensis, Neocelosporium corymbiae on stems of Corymbia variegata, Phytophthora kelmanii from rhizosphere soil of Ptilotus pyramidatus, Pseudosydowia backhousiae on living leaves of Backhousia citriodora

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