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Journal articles on the topic 'Commencement speakers'

Author: Grafiati
Published: 7 June 2025
Last updated: 16 July 2025

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1

Pascual, Roy Angelo, and Deveyvon Espinosa. "Sharing of Success Stories: Politeness Strategies of Commencement Speakers." Psychology and Education: A Multidisciplinary Journal 29, no. 5 (2024): 674–91. https://doi.org/10.5281/zenodo.14546192.

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In context of ceremonial discourse, commencement speeches serve as a significant platform for sharing success narratives, imparting words of wisdom and giving motivation as well as inspiration to graduating individuals. This study undertook a discourse analysis to unveil and explore the employment of politeness strategies by commencement speakers in sharing success stories during graduation ceremonies.  Limited to twenty (20) YouTube videos, the research scrutinized the linguistic choices within the speeches. Among the identified strategies, positive politeness emerged as the most frequen
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2

Mubarak, Ahmed Sahib, and Kadhim Ketab Rhaif. "Investigating pragma-rhetorical strategies utilized by American commencement speakers to motivate graduates for managing future opportunities and challenges." Linguistics and Culture Review 5, S1 (2021): 342–62. http://dx.doi.org/10.21744/lingcure.v5ns1.1399.

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Motivating emotions is a critical factor in empowering students to manage the troubles they might face. Educational organizations pay great efforts to employ all the available means that can motivate their students for better learning from early stages until universities or institutes levels. The administrations of some universities and institutes, especially in the United States of America, do not stop there and pay more attention on motivating their students at the graduation parties on how to manage future businesses and challenges. This study explores how commencement speakers utilize succ
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Shabelnyk, K., and Y. Torhovets. "STRUCTURAL FEATURES OF MODERN ENGLISH COMMENCEMENT SPEECHES." Studia Philologica 1, no. 16 (2021): 35–41. http://dx.doi.org/10.28925/2311-2425.2021.165.

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This paper investigates structural features of modern English commencement speeches. In the article, the commencement speech is defined as a speech delivered at the graduation ceremony by outstanding people, who gained national or international recognition in some field (e.g. science, medicine, business or entertainment). We suggest that commencement address belongs to the entertaining-commemorating type of discourse and its main purpose is to show respect and inspire graduates, to honour the beginning of their independent life. To meet the needs of the study Nagorska’s approach to the speech
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Warmke, Brandon. "Commencement Speech Morality." Social Philosophy and Policy 42, no. 1 (2025): 144–62. https://doi.org/10.1017/s0265052525000135.

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AbstractWe are never more high-minded about what matters in life than when we are at commencement ceremonies. As new graduates prepare to head into the real world, speakers tell them that to live meaningful lives they need to get out there and make their mark: change the world, upset the status quo, solve the biggest problems, and shape the revolutions of our time. But is this good life advice? Not really. Commencement Speech Morality encourages young people to become moralizers and busybodies. We should be wary of preaching it.
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Olii, Sanerita T., Devita A. Humiang, and Ignatius J. C. Tuerah. "An Analysis of Illocutionary Acts in Taylor Swift’s Speech at NYU's 2022 Commencement." Journal of English Culture, Language, Literature and Education 11, no. 2 (2023): 277–92. http://dx.doi.org/10.53682/eclue.v11i2.7032.

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This present study offers a comprehensive analysis of the illocutionary acts in Taylor Swift's commencement speech delivered at New York University (NYU) in 2022. Illocutionary acts, a crucial component of speech acts theory, encompass the speaker's intended communicative functions, such as asserting, commanding, questioning, or expressing emotions. Taylor Swift's speech is examined in the context of illocutionary acts to uncover the underlying intentions and rhetorical strategies used in the address. Illocutionary acts refer to speech acts aimed at achieving specific communicative functions o
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Duku, Berengar Irene, Obed Nii Broohm, and Elvis ResCue. "Exploring the semantic and pragmatic functions of modal auxiliaries: A case study of commencement speeches." Legon Journal of the Humanities 35, no. 1 (2024): 192–226. http://dx.doi.org/10.4314/ljh.v35i1.6.

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The use of modal auxiliaries in research articles and political speeches has been well investigated. The genre of commencement speeches, however, has yet to be investigated as far as the use of modal auxiliaries are concerned. In addressing the gap, the present study compares the usage of modal auxiliary verbs in commencement speeches of Ghanaian speakers with American speakers, and investigates the semantic contribution of the modal auxiliaries in the speeches. Additionally, the study also explores the speech act performed via the usage of the modal auxiliary verb and their pragmatic nuances
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7

Tiggelen, Brigitte Van. "Not an Epilogue, but a Commencement!" Chemistry International 41, no. 3 (2019): 58. http://dx.doi.org/10.1515/ci-2019-0319.

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Abstract To many non-native, or non-American, English speakers, the word “commencement” sounds like a strange choice to designate the end of a university curriculum. But then, all speeches and celebration talks given on commencement day focus on the future, and what students must take away from the years leading to graduation in a world full of opportunities, challenges, and unknowns. The same applies to our work on the history of IUPAC. It was started in the wake of the IUPAC 100th anniversary, and it will be mentioned among other presentations during the IUPAC centenary celebrations, but for
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Bogdanowska-Jakubowska, Ewa. "The discursive construction of high achievers’ identities in American culture." Lodz Papers in Pragmatics 14, no. 2 (2018): 249–71. http://dx.doi.org/10.1515/lpp-2018-0013.

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Abstract It is a study of the discursive construction of high achievers’ identities in American culture. A corpus of 100 commencement speeches delivered during 2016 and 2017 graduation ceremonies in American universities has been used to analyse how commencement speakers, as a rule highly successful individuals, construct their identities through discourse. Besides celebrating academic achievements, one of the communicative purposes of the commencement speech is giving the graduates advice for the future. It has been investigated how the speakers legitimize their qualifications as a role model
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9

Venter, C. J. "Taalideologie en Afrikatale: universiteitstudente se persepsie daarvan in ’n postapartheidsbedeling in Suid-Afrika." Literator 24, no. 3 (2003): 113–38. http://dx.doi.org/10.4102/lit.v24i3.303.

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Language ideology and African languages: The perception of university students in a post-apartheid South Africa Since the commencement of the new South African Constitution in 1996 student numbers in African languages at the Potchefstroom University for Christian Higher Education have dropped dramatically. It is argued in this article that this problematic situation should not be attributed to an inefficient language policy or ineffective course material, but rather to an ideological climate that is counter-productive to the optimal functioning of African languages as languages of education. I
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Wijaya, Kristian Florensio. "The Benefits of Activating Self-Regulation Behavior in Worldwide EFL Speaking Learning Contexts." SAGA: Journal of English Language Teaching and Applied Linguistics 6, no. 1 (2025): 31–42. https://doi.org/10.21460/saga.2025.61.205.

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Transforming worldwide EFL learners into more proficient L2 speakers is a challenging mission as speaking is not merely about the meaningful communication occurrences among interlocutors but also the strong willingness shouldered by EFL learners to regulate their certain behaviors and actions to achieve the targeted learning objectives fully. The previous research results strongly suggested that EFL educators establish, nurture, and reinforce their learners’ self-regulation at the commencement of speaking-focused learning activities in order to make them more confident L2 speakers who are will
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11

Shwartz, Mila, Mark Leikin, and David L. Share. "Bi-literate bilingualism versus mono-literate bilingualism." Written Language and Literacy 8, no. 2 (2005): 103–30. http://dx.doi.org/10.1075/wll.8.2.08shw.

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The present study compared the early Hebrew (L2) literacy development of three groups; two groups of bilinguals — bi-literate and mono-literate Russian-Hebrew speakers, and a third group of monolingual Hebrew-speakers. We predicted that bi-literacy rather than bilingualism is the key variable as regards L2 literacy learning. In a longitudinal design, a variety of linguistic, meta-linguistic and cognitive tasks were administered at the commencement of first grade, with Hebrew reading and spelling assessed at the end of the year. Results demonstrated that bi-literate bilinguals were far in advan
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Bogdanowska-Jakubowska, Ewa. "Work ethos in American ceremonial discourse addressed to the young." Discourse & Communication 14, no. 6 (2020): 561–79. http://dx.doi.org/10.1177/1750481320939709.

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The article discusses work ethos in American ceremonial discourse addressed to the young entering adult life. Its aim is to investigate whether the Protestant work ethic still pervades the American thinking about work. Through a qualitative analysis of the corpus of 100 randomly selected commencement addresses delivered during 2016 and 2017 graduation ceremonies in American universities, it is shown how work-related topics are employed by the speakers celebrating the graduates’ academic achievements and providing them with advice for the future. The Discourse-Historical Approach, committed to
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Yerznkyan, Yelena, and Lusine Harutyunyan. "A pragmalinguistic study of the strategies in motivational discourse (Based on Mark Zuckerberg’s Harvard commencement speech)." International Journal of English Language and Literature Studies 13, no. 2 (2024): 97–108. http://dx.doi.org/10.55493/5019.v13i2.4982.

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The present paper addresses the main pragmalinguistic strategies employed by speakers within the framework of motivational discourse. Motivational discourse is defined as a verbal and non-verbal influence on the person to positively change their attitudes, actions and behaviour. The research specifically focuses on Mark Zuckerberg's 2017 commencement speech to Harvard graduates. The study uses discourse analysis to pinpoint different linguistic and pragmatic methods as well as the main speech acts that Zuckerberg uses in order to motivate and inspire his audience. The researchers identify the
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14

Wijaya, Kristian Florensio. "The Positive Effects of Problem-Based Learning Activities Toward Indonesian EFL Learners' Productive Language Skills." JET (Journal of English Teaching) 8, no. 2 (2022): 182–94. http://dx.doi.org/10.33541/jet.v8i2.3409.

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 With the rapid globalization occurring all around the globe, educational landscapes also underwent some dramatic shifts in terms of teaching methods, policy-makers, and school culture. One of those indispensable trajectories that need to be taken into account by EFL educators is the pedagogical approach. Since learners no longer learn directly from one-on-one interaction with their teachers, it has been high time for educationalists to supersede their teaching-centered with the student-centered learning approach. In Indonesian EFL productive language learning contexts; speaking
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15

Arnold, Louise, Richard Kelly, Talha Munir, et al. "Thrombotic Events with Neisseria Meningitidis Vaccination in Patients with Paroxysmal Nocturnal Hemoglobinuria, UK Experience." Blood 136, Supplement 1 (2020): 35–36. http://dx.doi.org/10.1182/blood-2020-141769.

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic and thrombotic condition. Patients can experience severe anemia due to intravascular hemolysis, thrombotic events, renal impairment and pulmonary hypertension. Symptomatic patients are treated with complement inhibitors either in clinical trials or with eculizumab the only licensed treatment in the UK. Due to the mechanism of action of eculizumab, it increases susceptibility to Neisseria infection, including Neisseria meningitidis. To reduce this risk of infection, worldwide practice is for patients to be vaccinated at least 2 weeks
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16

Pramesthi, Jasmine Alya. "Analisis Pidato Kajian Retorika Aristoteles pada YouTube Video Perayaan Wisuda Virtual." JKOMDIS : Jurnal Ilmu Komunikasi Dan Media Sosial 3, no. 3 (2023): 701–8. http://dx.doi.org/10.47233/jkomdis.v3i3.1201.

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The state of COVID-19 that occurs in almost all parts of the world has made various activities carried out virtually from home in accordance with government policies. With all the activities done from home will cause several mental health problems. In order to provide support to the community, especially 2020 graduates who failed to celebrate graduation face-to-face, YouTube on June 7, 2020 broadcasts original content directly to carry out virtual graduation celebrations to congratulate, convey enthusiasm and inspiration to graduates with the title "Dear Class of 2020 ", one of the contents is
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17

Szer, Jeffrey, Cecily J. Forsyth, and Anja Giese. "Real-World Use of Therapeutic Anticoagulation in Patients with Paroxysmal Nocturnal Hemoglobinuria. Results of a Survey of Physicians in Australia." Blood 126, no. 23 (2015): 4537. http://dx.doi.org/10.1182/blood.v126.23.4537.4537.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and life-threatening hematopoietic stem cell disorder characterized by uncontrolled complement-mediated hemolysis. Patients with PNH are at increased risk of thromboembolism and premature death. This risk is predominantly due to the effects of chronic hemolysis and platelet activation. Eculizumab, a monoclonal antibody that inhibits terminal complement activation, has been shown to reduce hemolysis and dramatically reduce the rate of thromboembolism. A previous publication (Kelly et al, 2011) suggested that cessation of therapeutic a
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18

Arnold, Louise, Ray Borrow, Kathryn Riley, et al. "Management of Meningococcal Disease Risk in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) on Complement Inhibitors: 18 Years' Experience from the UK National PNH Service in Leeds." Blood 136, Supplement 1 (2020): 5–6. http://dx.doi.org/10.1182/blood-2020-141780.

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Eculizumab, the monoclonal antibody targeting C5, is the only licensed treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH) in the UK. Inherent to the mechanism of action, C5 inhibitors increase patient susceptibility to encapsulated microorganisms, particularly Neisseria meningitidis. The PNH National service (UK), has 18 years of experience treating patients with PNH using complement inhibition. The risk of N. meningitidis is mitigated by vaccination, ciprofloxacin (500 mg bd) on days 1-13 since we moved to vaccination on day one of complement inhibitor therapy, followed by daily prophyla
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19

Yeung, David T., Andrew Grigg, Naranie Shanmuganathan, et al. "Pro-Active Dasatinib Dose Reduction Based on Trough Levels May Minimise Toxicity and Preserve Efficacy - Interim Analysis of the ALLG CML 12 Direct Study." Blood 134, Supplement_1 (2019): 4150. http://dx.doi.org/10.1182/blood-2019-127619.

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Dasatinib treatment leads to excellent molecular responses in chronic phase chronic myeloid leukemia (CP-CML). Pleural effusions, an adverse event related dasatinib treatment, may lead to intolerance and drug discontinuations. Strategies aimed at minimising this may improve outcomes. In the Phase III Dasision study, pleural effusion affected ~22% of patients after 4 years of dasatinib treatment at 100mg/d (Cortes et al, 2016 JCO 34(20) 2333-40). The elderly are at particular risk (Latagliata et al 2013 Hem Onc 31(2) 103-9), and there is suggestion that higher dasatinib trough (Cmin) levels may
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20

Tochigi, Taro, Takatoshi Aoki, Yoshikane Kikushige, et al. "Mobilization of Human Immature Hematopoietic Progenitors after Combinatory Use of Bortezomib and Immunomodulatory Drugs." Blood 126, no. 23 (2015): 316. http://dx.doi.org/10.1182/blood.v126.23.316.316.

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Abstract Introduction: Combination of proteasome inhibitor (PI) bortezomib and immunomodulatory drugs (IMiDs), lenalidomide or thalidomide, have revealed superior outcomes in multiple myeloma (MM) over their single use. PI and IMiDs possess their direct anti-tumor activity as well as exert the indirect pleiotropic biological effects by modulating immune response, cytokine production, cell adhesion molecule, anti-apoptotic factors, cell cycle regulators. We recently found that circulating immature granulocytes and erythrocytes/megakaryocytes frequently appeared in peripheral blood (PB) in patie
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21

Handunnetti, Sasanka M., Mary Ann Anderson, Kate Burbury, et al. "Three Year Update of the Phase II ABT-199 (Venetoclax) and Ibrutinib in Mantle Cell Lymphoma (AIM) Study." Blood 134, Supplement_1 (2019): 756. http://dx.doi.org/10.1182/blood-2019-126619.

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Background: The phase II AIM trial (Tam et al, NEJM 2018; NCT02471391), using combination BTK inhibitor ibrutinib (IB) and BCL-2 inhibitor venetoclax (VEN) therapy achieved excellent 16 week complete remission rates (CRR) (primary endpoint; 62%) in patients (pts) with poor prognosis mantle cell lymphoma (MCL), higher than currently approved second line IB monotherapy. Additionally, overall response rate (ORR) by PET of 71%, with attainment of minimal residual disease (MRD) negativity was reported. At the time of primary endpoint analysis (median follow up 15.9 months), median progression free
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22

Gaisin, I., L. Ivanova, N. Maximov, A. Vedekhina, D. Yurk, and N. Garaeva. "SAT0107 BIOLOGIC THERAPY WITH RITUXIMAB DECREASES PREVALENCE OF ANXIETY AND DEPRESSION IN RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 987.1–987. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3044.

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Background:Evidence suggests rheumatoid arthritis (RA) confers an increased risk of psychological morbidity, particularly anxiety and depression, which may affect the subsequent management and treatment adherence.1,2Few studies have studied psychological factors over time in RA patients.3Objectives:To evaluate the prevalence of anxiety and depression in RA patients following rituximab treatment.Methods:92 biologics-naïve RA patients [mean (SD) age 49.5 (9.9) years, 78 women; median (IQR) DAS28 5.67 (3.94–8.45); median (IQR) HAQ 1.87 (1.2–3.5)] were followed up for 27 months after commencing an
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23

Sandhu, Suneet, Devinder Gill, Paul David Turner, et al. "Quality of Life in Fit Elderly Patients with Chronic Lymphocytic Leukemia (CLL) Receiving Oral Fludarabine-Based Regimens As First Line Therapy: Australasian Leukaemia and Lymphoma Group (ALLG) CLL5 Trial." Blood 126, no. 23 (2015): 5295. http://dx.doi.org/10.1182/blood.v126.23.5295.5295.

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Abstract Background The diagnosis and treatment of CLL may have a great impact on the quality of life (QoL) due to a variety of reasons including disease-related symptoms, infection, effects of therapy and the emotional, socio-economic, and functional effects of living with an 'incurable' illness. The main aim of any treatment is to maximize QoL by inducing remission with minimal short- and long-term toxicity. Balancing disease and symptom control with QoL in elderly patients receiving CLL therapy regimens can be challenging. There is little published QoL data in elderly CLL patients receiving
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24

Akram, T., M. Siddique, H. A. Javed, J. Begum, J. Fourmy, and M. K. Nisar. "AB1183 TERIPARATIDE SWITCH TO BIOSIMILAR - IS IT COST EFFECTIVE?" Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1882.1–1882. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1970.

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Background:Teriparatide is an effective treatment option for osteoporosis however NICE restricts its use to patients with high disease burden. This was based on cost effectiveness evaluation of the originator (Forsteo®) and would be different for recently introduced generic preparation.Objectives:We wished to evaluate the current prescribing behaviour prior to a potential switch to generic version and associated cost savings.Methods:All patients prescribed Teriparatide since the commencement of specialist osteoporosis service in Aug 2014 at our University teaching hospital covering 350,000 pop
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25

Pawlyn, Charlotte, Faith E. Davies, Kara-Louise Royle, et al. "Lenalidomide Maintenance Prolongs Progression-Free Survival and Does Not Impact the Aggressiveness of Clinical Relapse: Data from Long-Term Follow up of the Myeloma XI Trial." Blood 134, Supplement_1 (2019): 1889. http://dx.doi.org/10.1182/blood-2019-126103.

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Background: The impact of the selective pressure of maintenance Lenalidomide has the potential to enhance disease aggressiveness at relapse and if this were the case would shorten the time to next therapy. Previously we have shown that Lenalidomide maintenance therapy in myeloma is associated with improved progression-free survival (PFS). This initial analysis defined PFS as the time to biochemical progression but at that time point not all patients will go on to second line treatment, with the time to treatment being variable dependent on the aggressiveness of disease behavior at relapse. We
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26

Begum, J., J. Fourmy, and M. K. Nisar. "SAT0648-HPR CAN A SPECIALIST NURSE REPLACE A CONSULTANT - AN INNOVATIVE MODEL FOR OSTEOPOROSIS CARE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1283.1–1283. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1986.

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Background:Specialist services are heavily reliant on a consultant reviewing a patient and discussing management options. However this can significantly delay treatment pathway owing to lack of sufficient consultant appointments. Clinical nurse specialists (CNSs) are an integral part of a multidisciplinary team employed to provide effective care for the diverse needs of patients with chronic conditions such as osteoporosis.Objectives:We designed an innovative proof-of-concept osteoporosis service with patients only consulting a metabolic bone CNS and a consultant providing remote oversight. Th
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27

Opat, Stephen, Robert Bird, Cecily J. Forsyth, et al. "Haemopoietic Improvement Following Iron Chelation for Transfusional Haemosiderosis in Patients with Haematopoietic Neoplasia and Aplastic Anaemia: An Observational Study." Blood 118, no. 21 (2011): 5050. http://dx.doi.org/10.1182/blood.v118.21.5050.5050.

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Abstract Abstract 5050 Background: The benefit of iron chelation therapy (ICT) in patients with thalassaemia major is well established; however its role in adults with haematopoietic neoplasia (HN) and aplastic anemia (AA) is less certain. Post hoc analysis of the EPIC study revealed ICT therapy was associated with improved haemopoietic parameters in approximately 20% of patients with myelodysplasia (MDS). Deferasirox has been reported to inhibit NF-kB, a key transcription factor involved in the inflammatory response. We speculate that deferasirox may have an additional action as an immunosupp
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28

Hutchings, Martin, Fritz C. Offner, Francesc Bosch, et al. "Phase 1 Study of CD19 Targeted 4-1BBL Costimulatory Agonist to Enhance T Cell (Glofitamab Combination) or NK Cell Effector Function (Obinutuzumab Combination) in Relapsed/Refractory B Cell Lymphoma." Blood 136, Supplement 1 (2020): 16–17. http://dx.doi.org/10.1182/blood-2020-136571.

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Background: Up to 50% of patients suffering from Non-Hodgkin`s lymphoma (NHL) become refractory to or relapse after treatment (M. Crump, Blood 2017). With this, the lack of curative outcomes for patients with both indolent and aggressive NHL subtypes remains an unmet medical need. The CD20 CD3 T cell bispecific antibody glofitamab induces specific T-cell activation and has demonstrated significant single agent activity in r/r NHL patients (NP30179 study, M. Dickinson, EHA 2020, Abstract S241). RO7227166, a CD19 targeted 4-1BBL (CD137) costimulatory agonist has shown synergistic anti-tumor acti
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Jaroenkitboworn, Kandaporn. "Connecting Strategies in Mark Zuckerberg’s Commencement Speech at Harvard University." rEFLections 28, no. 3 (2021): 395–418. http://dx.doi.org/10.61508/refl.v28i3.255685.

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This research aims to analyze Mark Zuckerberg’s Commencement Speech at Harvard University to explore its wording and the interaction between the speaker and the audience. A Multimodal Discourse Analysis approach (MDA), and the concepts of intertextuality and interdiscursivity were adopted in this study. The results show that intertextually, Mark Zuckerberg narrated his experiences and stories, quoting famous sayings, and inserting religious text into his speech. Interdiscursively, he imported different discourses including discourse on entrepreneurship, discourse on racism, and discourse on gl
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30

Wei, Andrew H., Glen A. Kennedy, Kirk L. Morris, et al. "Results of a Phase 2, Randomized, Double-Blind Study of Sorafenib Versus Placebo in Combination with Intensive Chemotherapy in Previously Untreated Patients with FLT3-ITD Acute Myeloid Leukemia (ALLG AMLM16)." Blood 136, Supplement 1 (2020): 36–38. http://dx.doi.org/10.1182/blood-2020-137334.

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Introduction Midostaurin is the only approved FLT3 inhibitor for combination with intensive induction and consolidation chemotherapy in newly diagnosed patients with FLT3 mutant AML. The FLT3 inhibitor, sorafenib, was investigated in the randomized SORAML trial (Röllig, Lancet Onc 2015), in combination with intensive chemotherapy (IC) for newly diagnosed adults with AML <60 years. A sub-group analysis of 46 patients with FLT3-ITD, indicated a trend for improved overall survival (OS) in the sorafenib (SOR) arm compared to placebo (PBO). Methods The Australasian Leukaemia and Lymphoma Gro
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31

Handunnetti, Sasanka M., Amit Khot, Mary Ann Anderson, et al. "Safety and Efficacy of Ibrutinib in Combination with Venetoclax in Patients with Marginal Zone Lymphoma: Preliminary Results from an Open Label, Phase II Study." Blood 134, Supplement_1 (2019): 3999. http://dx.doi.org/10.1182/blood-2019-126396.

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Background: Marginal zone lymphoma (MZL) is an incurable but heterogeneous disorder for which there is no standard of care treatment in the relapsed/refractory (R/R) setting. The BTK inhibitor, ibrutinib (IB) is well tolerated with an overall response rate (ORR) of 48% as monotherapy in R/R MZL but rarely complete remission (Noy et al, Blood, 2017). The BCL-2 inhibitor, venetoclax (VEN) has also been evaluated in a small number of R/R MZL patients (pts) with evidence of activity and tolerability (Davids et al, JCO, 2017). We sought to evaluate the efficacy and safety of combination IB and VEN
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White, Deborah L., Verity Saunders, Menelaou Andrew, et al. "Imatinib PK: Observations From the TIDEL II Study." Blood 116, no. 21 (2010): 2288. http://dx.doi.org/10.1182/blood.v116.21.2288.2288.

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Abstract Abstract 2288 Previous studies have demonstrated that the achievement of an imatinib (IM) trough level of 1000ng/ml in CP-CML patients is associated with a better response. The aim of this sub-study was to perform a detailed assessment of IM plasma levels in the TIDEL II trial, in which patients are treated with IM 600mg/day upfront with subsequent dose escalation to 400mg BID, or switch to nilotinib if pre-determined molecular milestones are not met. Patients failing to achieve a trough level of >1000ng/ml 22 days after the commencement of IM were scheduled to dose escalate to 400
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Lauw, Calvin, and Samuel Gunawan. "Rhetorical Devices Used by Mark Zuckerberg in His 2007 Harvard Commencement Speech." k@ta kita 12, no. 1 (2024): 86–93. http://dx.doi.org/10.9744/katakita.12.1.86-93.

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This research analyzed the rhetorical devices used by Mark Zuckerberg in his 2007 Harvard commencement speech. The findings show Mark Zuckerberg’s speech used six out of eleven rhetorical devices in figurative language such as simile, catachresis, synecdoche, personification, allusion, and transferred epithet. The most frequent rhetorical device he used is catachresis. The other frequent rhetorical device he used is the transferred epithet. The least used of rhetorical devices in his speech simile, personification and synecdoche. From the findings, the writer concludes the rhetorical devices a
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Peter Y. Toribio, Simon, Rosette D. Morandarte, and Jannet P. Paster. "Transitivity processes in the 2021 Commencement Speech of DepEd Sec. Leonor M. Briones." East Asian Journal of Multidisciplinary Research 2, no. 3 (2023): 1355–66. http://dx.doi.org/10.55927/eajmr.v2i3.3362.

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Grounded on Halliday's Systemic-Functional Grammar, this study explores the transitivity system in the 2021 Commencement Speech of DepEd Sec. Leonor Briones. It specifically aims to identify the transitivity processes and the dominant process found in the Commencement speech and to analyze the linguistic functions in this transitivity system. Employing an explanatory mixed-method design, the results shows that material, mental, relational, and existential processes are present in the Commencement Speech. Among the four identified transitivity process, the dominant is the material process (65%)
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35

Ramli, A. W., N. Nair, K. Hyrich, et al. "AB0337 BASELINE C-REACTIVE PROTEIN PREDICTS ADHERENCE TO ADALIMUMAB THERAPY AT 3 MONTHS IN AN OBSERVATIONAL COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1293.1–1293. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1482.

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BackgroundAdherence to biologic treatment in rheumatoid arthritis (RA) is often self-reported and little is known about the predictors of adherence to biologic medications. Many studies have reported the predictors of adherence to be linked to psychological factors. A systematic review [1] identified several predictors of adherence to methotrexate in RA patients with the strongest predictors related to psychological factors including beliefs in medication necessity and absence of low mood. Mild disease activity was also found to be a significant predictor of adherence from this study. It is un
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36

Ludwig, Heinz, Philippe Moreau, Meletios A. Dimopoulos, et al. "Health Related Quality of Life Results from the Open-Label, Randomized, Phase III Endeavor Trial Evaluating Carfilzomib and Dexamethasone Versus Bortezomib and Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma." Blood 128, no. 22 (2016): 3309. http://dx.doi.org/10.1182/blood.v128.22.3309.3309.

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Abstract Introduction: The randomized, phase 3 study ENDEAVOR (NCT01568866; N=929) demonstrated a clinically meaningful and statistically significant improvement in progression-free survival for patients with relapsed or refractory multiple myeloma who were treated with carfilzomib and dexamethasone (Kd) versus bortezomib and dexamethasone (Vd; median, 18.7 vs 9.4 months; hazard ratio: 0.53; 95% confidence interval [CI]: 0.44-0.65; P<0.0001) (Dimopoulos et al. Lancet Oncol. 2016;17:27−38). Patient-reported outcomes (PROs) were included as exploratory endpoints in the ENDEAVOR study. Here, w
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Chua, Chong Chyn, John Reynolds, Jessica M. Salmon, et al. "Anti-Leukemic Activity of Single Agent Venetoclax in Newly Diagnosed Acute Myeloid Leukemia: A Sub-Set Analysis of the Caveat Study." Blood 134, Supplement_1 (2019): 462. http://dx.doi.org/10.1182/blood-2019-126640.

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Background:The small molecule BCL-2 inhibitor Venetoclax (VEN) has emerged as a promising frontline therapy in combination with low dose cytarabine (LDAC) or hypomethylating agents in older patients with acute myeloid leukemia (AML)(DiNardo et al, Lancet Oncol 2018, Blood 2019; Wei et al,JCO 2019). The anti-leukemic activity of single agent VEN as monotherapy in newly diagnosed AML is unknown. This information would be useful for studies considering VEN as a maintenance therapy. We have previously presented preliminary outcomes from a phase 1b/2 study: Chemotherapy and Venetoclax in Elderly AM
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Barg, Assaf Arie, Gili Kenet, Tami Livnat, et al. "The Potential Role of Emicizuamb Prophylaxis in Severe Von Willebrand Disease." Blood 136, Supplement 1 (2020): 20. http://dx.doi.org/10.1182/blood-2020-138777.

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Severe Von Willebrand's disease (VWD) may be associated with chronic joint damage and may require prophylactic therapy. In severe VWD, factor VIII (FVIII) levels are low due to rapid clearness. Emicizumab is a humanized bispecific antibody which mimics the function of coagulation factor VIII (FVIII). It has been approved for prophylaxis in hemophilia A. This is the first study assessing the potential role of emicizumab as an alternative prophylactic treatment in a cohort of patients with severe VWD. We present a TG model evaluating patients' hemostasis following ex vivo spiking of their plasma
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Dickinson, Michael J., Kirsten Herbert, Caroline Sardjono, et al. "Final Analysis of a Phase II Study of Intrapatient Dose-Escalation of Eltrombopag in Patients Receiving Azacitidine for Myelodysplasia/AML." Blood 124, no. 21 (2014): 4657. http://dx.doi.org/10.1182/blood.v124.21.4657.4657.

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Abstract Background: Pre-existing thrombocytopenia in MDS/AML is worsened during the initial cycles of azacitidine (AZA) therapy, resulting in bleeding risk and possible platelet transfusion. Eltrombopag (EPG) is an oral TPO-receptor agonist. In vitro, it has anti-proliferative effects on AML blasts. Aim: To assess the safety of escalated doses of EPG in patients undergoing AZA for MDS/AML Method An investigator-initiated phase-II, single arm, study of EPG with AZA. Inclusion: relapsed or de-novo MDS/CMML/AML (blasts 5-30%); or symptomatic cytopenia; or blasts 31-50% if >/=65 years or previ
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40

Ma, Chenyang. "The Interpersonal Functional Analysis of Taylor Swift’s Commencement Address at New York University." Frontiers in Humanities and Social Sciences 5, no. 3 (2025): 271–78. https://doi.org/10.54691/scvd9751.

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As an American singer-songwriter, actress and music producer, Taylor Swift is known for her pop and country music compositions and considered as one of the most influential artists of the 21st century. Therefore, it is very meaningful to study the speeches delivered by famous musicians at graduation ceremonies. Based on the interpersonal function of Halliday’s systemic functional grammar, this paper takes Taylor Swift’s commencement address at New York University in 2022 as the corpus, analyzes the interpersonal meaning of the address from three angles including mood system, modality system as
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Amandari, Ni Putu Mutia, I. Made Netra, and Ni Made Suwari. "Critical discourse analysis on BTS commencement speech in dear class of 2020." Journal of Education, Social & Communication Studies 1, no. 2 (2024): 70–76. http://dx.doi.org/10.58881/jescs.v1i2.11.

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The aim of the study is to examine the representative of critic in CDA and the hidden meaning in BTS Commencement Speech in Dear Class of 2020. The analysis of this research based on theory of CDA and its analysis methods which were represented by Van Dijk. Whereas the discussion used descriptive qualitative research method which deals with data that are in the form of word, rather than statistics and attempts to arrive at a rich description of something systematically. It starts by analyzing the represented critic on the text and separated them into an expression from each data. Then, it is c
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42

Tempest, K., H. Reddy, S. Johns, K. Wright, and S. Sultan. "AB1397 WORK SMARTER NOT HARDER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1804.1–1804. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2263.

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BackgroundIn 2014 we were a small team with only 1 WTE (Whole Time Equivalent) CNS (Clinical Nurse Specialist) and 2 WTE consultants for a population of 220,000. Most CNS clinic appointments were taken up for drug counselling. Waiting times were approx. 6 weeks for drug counselling. Consultants would often counsel for DMARDs.That year at a national meeting a virtual group MDT (multidisciplinary) was presented by the team at Manchester Royal infirmary (MRI). They used a good quality presentation for patients starting bDMARDs as a tool for drug counselling.After having to put on an extra clinic
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Tan, Clive, Maria Abraham, Sharon Chua, Colin Tan, Angeline Lim, and Jason Cheah. "Structural reforms in action - Singapore's population health journey and the structural changes at the national and local level." International Journal of Integrated Care 23, S1 (2023): 187. http://dx.doi.org/10.5334/ijic.icic23661.

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Summary: This workshop explores the challenges and opportunities for health systems in transition using Singapore as a case study to explore:
 
 a) How the health system is shifting towards a population approach
 b) Change management and implementation approaches required at the macro, meso and micro level
 
 Background: Confronted with the challenges of an ageing population, rising prevalence of chronic diseases, and increasing healthcare costs – Singapore’s Ministry of Health has embarked on “Healthier SG”, an ambitious health transformation strategy which aims to sh
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Michallet, Mauricette, Peter Dreger, Mohamad Sobh, et al. "Salvage Use of Ibrutinib after Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) for B Cell Malignancies: A Study of the French Cooperative Group for CLL, the French Soceity for Blood and Marrow Transplantation (SFGM-TC), and the European Society for Blood and Marrow Transplantation (EBMT) Chronic Malignancy and Lymphoma Working Parties." Blood 128, no. 22 (2016): 4659. http://dx.doi.org/10.1182/blood.v128.22.4659.4659.

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Abstract BACKGROUND: Allo-HSCT is an accepted treatment option for patients with relapsed and refractory B cell lymphomas or high-risk chronic lymphocytic leukemia (CLL). This treatment option is currently reshaped by the introduction of pathway inhibitors (PWI) as ibrutinib, idelalisib, and venetoclax. However, the mid- and long-term efficacy and toxicity of these drugs are not yet fully defined and most patients need to discontinue their treatment over time because of disease progression or intolerance. Allo-HSCT could induce long-term disease control with curative potential especially in po
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45

Saft, Scott, Gabriel Tebow та Ronald Santos. "Hawaiʻi Creole in the public domain". Pragmatics. Quarterly Publication of the International Pragmatics Association (IPrA) 28, № 3 (2018): 417–38. http://dx.doi.org/10.1075/prag.16015.saf.

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Abstract In light of a belief that Hawaiʻi Creole (HC) is mostly inappropriate in public domains of society, this study examines how it was employed in two university commencement speeches by a local politician in Hawaiʻi. The analysis adopts the perspective of heteroglossia (Bakhtin 1981) in order to describe how HC is used together in the speeches with English and also some Hawaiian words. By focusing on the contrastive indexical meanings attached to all three languages, the analysis describes how the speaker combined humor and serious advice in his speeches. In particular, a focus is given
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46

Rossi, John M., Sattva S. Neelapu, William Y. Go, et al. "Phase 1 Biomarker Analysis of the ZUMA-1 (KTE-C19-101) Study: A Phase 1-2 Multi-Center Study Evaluating the Safety and Efficacy of Anti-CD19 CAR T Cells (KTE-C19) in Subjects with Refractory Aggressive Non-Hodgkin Lymphoma (NHL)." Blood 126, no. 23 (2015): 2730. http://dx.doi.org/10.1182/blood.v126.23.2730.2730.

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Abstract Introduction: A single institution study conducted at the National Cancer Institute (NCI) using anti-CD19 CAR T cells with CD28 and CD3-zeta signaling domains showed durable remissions in subjects with relapsed/refractory advanced B-cell malignancies (Kochenderfer et al. Blood 2012, JCO 2014, ASH 2014). In the NCI study, anti-CD19 CAR T cells expanded within 1 week of administration and generally cleared the peripheral blood within 2 months. Anti-CD19 CAR T cell infusion resulted in rapid elevation and subsequent resolution of circulating cytokines and chemokines within 3 weeks (Bot e
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47

Hiwase, Devendra K., David T. Yeung, Lisa Carne, David Ross, Andrew Grigg, and Timothy P. Hughes. "Hypercholesterolemia In Imatinib Intolerant/Resistant CML-CP Patients Treated With Nilotinib: A Retrospective Analysis." Blood 122, no. 21 (2013): 1503. http://dx.doi.org/10.1182/blood.v122.21.1503.1503.

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Abstract Background CML patients (pts) enjoy prolonged leukaemia-free survival with tyrosine kinase inhibitor (TKI) treatment. Addressing common non-CML causes of morbidity and mortality such as cardiovascular disease (CVD) and its associated risk factors is therefore increasingly important. Anecdotal evidence suggests a possible association between nilotinib (NIL) therapy and vascular events though there is little good quality evidence in this regard. The incidence of hyperlipidaemia and hyperglycaemia is higher in NIL-treated pts compared to imatinib- (IM) treated pts; conversely IM treatmen
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48

Box, C., E. Swann, H. Harris, and N. Mckay. "AB0472 FILGOTINIB FOR RHEUMATOID ARTHRITIS - AN OBSERVATIONAL STUDY TO ASSESS CLINICAL EFFECTIVENESS IN NHS LOTHIAN." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1429.1–1429. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1872.

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BackgroundFilgotinib (Jyseleca) is a Janus-kinase (JAK) inhibitor which in 2021 was approved for use in the UK in moderate or severe rheumatoid arthritis (RA) either as monotherapy or in combination with Methotrexate. A reduced dose of 100 mg is recommended for patients aged 75 years or over, or with moderate or severe renal impairment. Clinical efficacy of filgotinib alongside a conventional disease-modifying anti-rheumatic drug (cDMARD) was demonstrated in the FINCH 1 and FINCH 2 trials [1,2] but evidence of real-world effectiveness is currently limited.ObjectivesTo describe a cohort of pati
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Dieudé, P., J. Sparks, A. Fischer, et al. "POS1050 INCIDENCE RATES OF INTERSTITIAL LUNG DISEASE AMONG PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH ABATACEPT: A POST HOC POOLED ANALYSIS FROM A COMPENDIUM OF CLINICAL TRIALS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 843.2–843. http://dx.doi.org/10.1136/annrheumdis-2023-eular.250.

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BackgroundInterstitial lung disease (ILD) is a recognized complication of RA. Prior studies have suggested stabilization or improvement of ILD in patients with RA (RA-ILD) treated with abatacept.[1,2]Few studies have evaluated the background incidence rate of RA-ILD.ObjectivesTo determine the incidence rate of clinically significant ILD in a cohort of patients with RA receiving abatacept + MTX versus placebo + MTX from multiple clinical trials.MethodsThis retrospective analysis examined pooled safety data from ten phase 3 clinical trials of patients with RA treated with background MTX in combi
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50

Tan, Sarah Ai Ting, Steven Shih, Scarlett Olasope, Sharon R. Jackson, Sarah Poplar, and Henry Chan. "Bortezomib Induction and Consolidation in Patients with Multiple Myeloma Who Received Frontline Autologous Stem Cell Transplant." Blood 136, Supplement 1 (2020): 33. http://dx.doi.org/10.1182/blood-2020-140077.

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Introduction For multiple myeloma patients who are eligible for transplant determined by age and physiological reserve, autologous stem cell transplant (ASCT) following induction chemotherapy is considered as frontline treatment due to the better depth of response, progression-free (PFS) and overall survival (OS). Bortezomib is effective as part of a multi-agent induction regimen prior to ASCT as supported by long-term analysis with survival benefit. However, the role of Bortezomib and Thalidomide consolidation remains controversial. In New Zealand, Bortezomib was funded for up to nine cycles
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