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Journal articles on the topic 'COMMON INHIBITOR'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Arita, Minetaro, Takaji Wakita, and Hiroyuki Shimizu. "Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime." Journal of General Virology 90, no. 8 (2009): 1869–79. http://dx.doi.org/10.1099/vir.0.012096-0.

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Previously, we identified a cellular kinase inhibitor, GW5074, that inhibits poliovirus (PV) and enterovirus 71 replication strongly, although its target has remained unknown. To identify the target of GW5074, we searched for cellular kinase inhibitors that have anti-enterovirus activity similar or related to that of GW5074. With this aim, we performed screenings to identify cellular kinase inhibitors that could inhibit PV replication cooperatively with GW5074 or synthetically in the absence of GW5074. We identified MEK1/2 inhibitors (SL327 and U0126), an EGFR inhibitor (AG1478) and a phosphat

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Hopkins, Michael, John J. Tyson, and Béla Novák. "Cell-cycle transitions: a common role for stoichiometric inhibitors." Molecular Biology of the Cell 28, no. 23 (2017): 3437–46. http://dx.doi.org/10.1091/mbc.e17-06-0349.

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The cell division cycle is the process by which eukaryotic cells replicate their chromosomes and partition them to two daughter cells. To maintain the integrity of the genome, proliferating cells must be able to block progression through the division cycle at key transition points (called “checkpoints”) if there have been problems in the replication of the chromosomes or their biorientation on the mitotic spindle. These checkpoints are governed by protein-interaction networks, composed of phase-specific cell-cycle activators and inhibitors. Examples include Cdk1:Clb5 and its inhibitor Sic1 at

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3

Luan, Hengjie, Mingkang Liu, Qinglin Shan, Yujing Jiang, Peng Yan, and Xiaoyu Du. "Experimental Study on the Effect of Mixed Thermodynamic Inhibitors with Different Concentrations on Natural Gas Hydrate Synthesis." Energies 17, no. 9 (2024): 2078. http://dx.doi.org/10.3390/en17092078.

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Natural gas hydrate (NGH) is a potential future energy resource. More than 90% of NGH resources exist in the pore medium of seafloor sediments. During the development of deep-sea oil and gas fields, wellbore pipelines are often clogged due to the synthesis of gas hydrates, and the addition of thermodynamic inhibitors is a common solution to prevent hydrate synthesis. In this paper, the effects of two single inhibitors, sodium chloride and ethylene glycol, as well as hybrid inhibitors combining these two inhibitors on the synthesis of methane hydrates were investigated using the self-developed

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4

Watson, R. J., and B. Blackwell. "Purification and characterization of a common soil component which inhibits the polymerase chain reaction." Canadian Journal of Microbiology 46, no. 7 (2000): 633–42. http://dx.doi.org/10.1139/w00-043.

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DNA prepared from soil usually contains a brown-tinted inhibitor of the polymerase chain reaction (PCR) which limits the sensitivity of this technique for specific detection of microorganisms. To localize the inhibitor, soil fractions were tested for their inhibitory effect on the PCR reaction. A highly inhibitory activity, sufficient to account for the inhibition typically exhibited by soil DNA, was found to be tightly associated with the soil microorganism fraction. After cell breakage, the inhibitory material became soluble, and was not separable from DNA by standard purification procedures

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E, Jingwen, Ye Liu, Shanshan Guan, et al. "How Different Substitution Positions of F, Cl Atoms in Benzene Ring of 5-Methylpyrimidine Pyridine Derivatives Affect the Inhibition Ability of EGFRL858R/T790M/C797S Inhibitors: A Molecular Dynamics Simulation Study." Molecules 25, no. 4 (2020): 895. http://dx.doi.org/10.3390/molecules25040895.

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Lung cancer is the most frequent cause of cancer-related deaths worldwide, and mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are a common cause of non-small-cell lung cancers, which is a major subtype of lung cancers. Recently, a series of 5-methylpyrimidine-pyridinone derivatives have been designed and synthesized as novel selective inhibitors of EGFR and EGFR mutants. However, the binding-based inhibition mechanism has not yet been determined. In this study, we carried out molecular dynamic simulations and free-energy calculations for EGFR derivatives to fill

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El-latif, Ashraf Oukasha Abd. "Protease purification and characterization of a serine protease inhibitor from Egyptian varieties of soybean seeds and its efficacy against Spodoptera littoralis." Journal of Plant Protection Research 55, no. 1 (2015): 16–25. http://dx.doi.org/10.1515/jppr-2015-0003.

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Abstract Serine inhibitors have been described in many plant species and are universal throughout the plant kingdom. Trypsin inhibitors are the most common type. In the present study, trypsin and chymotrypsin inhibitory activity was detected in the seed flour extracts of four Egyptian varieties of soybean (Glycine max). The soybean variety, Giza 22, was found to have higher trypsin and chymotrypsin inhibitory potential compared to other tested soybean varieties. For this reason, Giza 22 was selected for further purification studies which used ammonium sulphate fractionation and DEAE-Sephadex A

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Chen, Shanshan, Yutong Xue, Liping Peng, et al. "Research Progress on Types and Mechanism of Common Organic Corrosion Inhibitors." International Journal of Energy 2, no. 3 (2023): 9–12. http://dx.doi.org/10.54097/ije.v2i3.8739.

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In this paper, several kinds of common organic corrosion inhibitors, such as heterocyclic, aldehydes and ketones, organic phosphonic acid, are introduced. The development prospects and application limitations of some corrosion inhibitors are discussed and pointed out. There are also studies have shown that usually two or more corrosion inhibitors are combined or better than a single corrosion inhibitor. Taking the effect as the introduction point, the mechanism of action of organic corrosion inhibitors is generally recognized. Finally, the future research direction of organic corrosion inhibit

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Gao, Xuejun, Dandan Xue, Jingjing Cheng, Xin Zhang, and Xia Cai. "Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells." Journal of Oncology 2022 (March 11, 2022): 1–9. http://dx.doi.org/10.1155/2022/2946929.

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Melanoma is a malignant tumor produced by highly aggressive and metastatic melanocytes. NRAS mutation is a relatively common mutation in melanoma cells. Mitogen-activated protein kinase (MAPK) signaling pathway and the PI3K/Akt pathway in melanoma cells are relatively common signaling pathways. In this study, we investigated the effect of inhibition of Axl expression on the targeted inhibition of the PI3K/Akt pathway in NRAS-mutant melanoma cells. In this study, immunohistochemistry and western blot methods were used to detect the expression of Axl and Akt proteins in melanoma cells. Axl inhib

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9

Wei, Jia, Ling Ma, Chenglong Li, Christopher R. Pierson, Jonathan L. Finlay, and Jiayuh Lin. "Targeting Upstream Kinases of STAT3 in Human Medulloblastoma Cells." Current Cancer Drug Targets 19, no. 7 (2019): 571–82. http://dx.doi.org/10.2174/1568009618666181016165604.

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Background:Medulloblastoma is the most common malignant brain tumor in children. Despite improvement in overall survival rate, it still lacks an effective targeted treatment strategy. The Janus family of cytoplasmic tyrosine kinases (JAKs) and Src kinases, upstream protein kinases of signal transducer and activator of transcription 3 (STAT3), play important roles in medulloblastoma pathogenesis and therefore represent potential therapeutic targets.Methods:In this report, we examined the inhibitory efficacy of the JAK1/2 inhibitor, ruxolitinib, the JAK3 inhibitor, tofacitinib and two Src inhibi

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Königs, Christoph, Christoph Kessel, Susanne Stumpf, Janti Roland, Thomas Klingebiel, and Wolfhart Kreuz. "Inhibitor Epitopes Identified from Inhibitor Positive Plasma of a Hemophilia B Patient Change during ITT." Blood 106, no. 11 (2005): 3201. http://dx.doi.org/10.1182/blood.v106.11.3201.3201.

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Abstract Hemophilia B is an X-linked bleeding disorder. Substitution of recombinant (rFIX) or plasma derived (pdFIX) FIX preparations are required to restore coagulation. A rare but severe complication is the development of FIX inhibitors that are often accompanied by allergic reactions. Immune tolerance therapies (ITTs) for inhibitor elimination are difficult and can induce further allergic reactions. ITTs for FIX inhibitors are less established and less successful than for FVIII inhibitors. In this study, three phage displayed random peptide libraries were screened by biopanning to isolate s

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11

S. A. Elmaryami, Abdlmanam, Abdullah Abraheem Abdullah, Miftah Ali Mohammed, et al. "An evaluation of wood ashes as an eco-friendly environmentally corrosion inhibitor for low carbon steel in acidic solution at different temperatures." Zastita Materijala 66, no. 2 (2025): 412–20. https://doi.org/10.62638/zasmat1236.

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Corrosion is an unavoidable fact in everyday life but always receive attention to control due to its technical, economical, and esthetical importance. Carbon steel (CS) is the most commonly used material for equipment and pipes in the oil production processes. However, presence of water/salts and carbon dioxide, among other gases, in the oil is a serious problem due to increased corrosion rate of the material. The most common way of mitigating this problem is by using corrosion inhibitors. However, many common corrosion inhibitors that are in use today are health hazards. Corrosion inhibitors

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12

Shi, Yun Feng, Li Li Zhang, Mu Qiu Zhao, and Gang Wang. "Inhibitory Effects of Aqueous Extracts from Leaves of Common Tropical Green Plants on Urea Hydrolysis in Soils." Advanced Materials Research 1010-1012 (August 2014): 614–17. http://dx.doi.org/10.4028/www.scientific.net/amr.1010-1012.614.

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Tropical plants contain a variety of secondary metabolites, and plant aqueous extracts can be used as urease inhibitors to improve nitrogen use efficiency and reduce the negative environmental effects. An incubation experiment was carried out to investigate the effects of aqueous extracts of 32 common tropical green plant species from 24 families on urea hydrolysis. The results indicated that the aqueous extracts from 3 of the common tropical green plants (Pterocarpus indicus, Callistemon rigidus, Terminalia mantaly) belonging to Leguminosae, Myrtaceae and Combretaceae respectively showed bett

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Hale, J. P., and M. Burrows. "Innervation patterns of inhibitory motor neurones in the thorax of the locust." Journal of Experimental Biology 117, no. 1 (1985): 401–13. http://dx.doi.org/10.1242/jeb.117.1.401.

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The innervation pattern of inhibitory motor neurones of the locust has been revealed by intracellular recording from their cell bodies in the meso- and metathoracic ganglion and simultaneous recording from muscle fibres in a middle, or in a hind leg. Three neurones in each ganglion, the common inhibitor (CI = CI1), the anterior inhibitor (AI = CI2), and the posterior inhibitor (PI = CI3) innervate several muscles in one leg and are thus common inhibitory neurones. Metathoracic CI innervates 13 muscles in one hind leg and mesothoracic CI innervates 12 muscles in one middle leg. The muscles are

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14

Peddio, Stefania, Sonia Lorrai, Tinuccia Dettori та ін. "Purification and Characterization of Proteinaceous Thermostable α-Amylase Inhibitor from Sardinian Common Bean Nieddone Cultivar (Phaseolus vulgaris L.)". Plants 13, № 15 (2024): 2074. http://dx.doi.org/10.3390/plants13152074.

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The increasing need for new treatments for obesity and diabetes has led to the development of new drugs and food supplements that could reduce carbohydrate absorption. Many starch blockers, based on common bean proteinaceous inhibitors against α-amylase (α-AI), are already present on the market. The extraction and purification of α-amylase inhibitor from a promising common bean cultivar from Sardinia (Nieddone) is described, highlighting the unique value of the Nieddone cultivar, particularly for its inhibitory activity on digestive enzymes and its complete lack of a hemagglutination effect on

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15

Philips, M., Anne-Grethe Juul, S. Thorsen, J. Selmer, and J. Zeuthen. "Immunological Relationship Between the Fast-Acting Plasminogen Activator Inhibitors from Plasma, Blood Platelets and Endothelial Cells Demonstrated with a Monoclonal Antibody Against an Inhibitor from Placenta." Thrombosis and Haemostasis 55, no. 02 (1986): 213–17. http://dx.doi.org/10.1055/s-0038-1661524.

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SummaryTwo plasminogen activator inhibitors (I and II) were demonstrated in human placenta. The complex between inhibitor I and tissue-type plasminogen activator was purified by immunoadsorption to solid-phase anti-activator antibodies. The purified complex (Mr 95.000) was used for immunization of mice and subsequent production of monoclonal antibodies. One antibody (F37), which reacted with both free and complex-bound inhibitor I, was used for further study by a method involving binding of the antibody to protein A-Sepharose, immunoadsorp-tion of antigen and analysis of the resulting supernat

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16

Scandella, Dorothea. "Epitope Specificity of Factor VIII Inhibitor Antibodies." Hämostaseologie 18, no. 03 (1998): 121–28. http://dx.doi.org/10.1055/s-0038-1655342.

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SummaryAntibodies that inactivate factor VIII develop most frequently in patients with severe hemophilia A, and they present a serious complication in the therapy of such individuals. Most patients with inhibitors have two or more different antibodies capable of factor VIII inactivation in their plasma, as shown by assays in which several factor VIII domain fragments are tested for neutralization of the inhibitor activity. Such neutralization assays of 23 patient plasmas suggest that there are three common epitopes. These epitopes have been localized by several methods to the A2, A3, and C2 fa

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17

Scandella, D., GE Gilbert, M. Shima, et al. "Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site." Blood 86, no. 5 (1995): 1811–19. http://dx.doi.org/10.1182/blood.v86.5.1811.bloodjournal8651811.

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The finding that human factor VIII (fVIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of fVIII to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate fVIII. We constructed a recombinant C2 domain polypeptide and demonstrated that it bound to all six human inhibitors with fVIII light chain specificity. Thus, some antibodies within the polyclonal anti-light chain population require only amino acids within C2 for binding. Recombinant C2 also partially or completely neutralized the inhibitor titer of these plasmas, demonstrating that a

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18

Armel, Gregory R., Patrick L. Rardon, Michael C. McComrick, and Nancy M. Ferry. "Differential Response of Several Carotenoid Biosynthesis Inhibitors in Mixtures with Atrazine." Weed Technology 21, no. 4 (2007): 947–53. http://dx.doi.org/10.1614/wt-06-133.1.

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Greenhouse studies were conducted in 2003 at the Stine–Haskell Research Center to determine whether herbicide inhibitors of six specific sites in the carotenoid biosynthesis pathway would elicit synergistic responses when applied postemergence (POST) in combination with the photosystem II (PSII) inhibitor atrazine. Based on data analysis with the Isobole method, synergistic responses were observed on red morningglory, common cocklebur, and giant foxtail when atrazine was applied in mixtures with the deoxy-D-xylulose-5-phosphate reductoisomerase (DOXP reductoisomerase) inhibitor fosmidomycin, t

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19

&NA;. "Lipodystrophy syndrome common during protease inhibitor therapy." Reactions Weekly &NA;, no. 757 (1999): 5. http://dx.doi.org/10.2165/00128415-199907570-00013.

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20

Kang, Joyeon, Doyeon Lee, Kyoung Jin Lee, et al. "Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer." Cancers 14, no. 12 (2022): 2881. http://dx.doi.org/10.3390/cancers14122881.

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Myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment contribute to tumor progression by inducing immune tolerance to tumor antigens and cancer cells. Metformin, one of the most common diabetes drugs, has shown anti-inflammatory and anti-tumor effects. However, the effects of metformin on inflammatory cells of the tumor microenvironment and its underlying mechanisms remain unclarified. In this study, we investigated the effect of metformin on M2 macrophages and MDSCs using monocyte THP-1 cells and a dextran sodium sulfate (DSS)-treated ApcMin/+ mouse model o

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21

Silva, Maria Cristina Mattar da, Luciane Vieira Mello, Marise Ventura Coutinho, et al. "Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases." Pesquisa Agropecuária Brasileira 39, no. 3 (2004): 201–8. http://dx.doi.org/10.1590/s0100-204x2004000300001.

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Despite the presence of a family of defense proteins, Phaseolus vulgaris can be attacked by bruchid insects resulting in serious damage to stored grains. The two distinct active forms of a-amylase inhibitors, a-AI1 and a-AI2, in P. vulgaris show different specificity toward a-amylases. Zabrotes subfasciatus a-amylase is inhibited by a-AI2 but not by a-AI1. In contrast, porcine a-amylase is inhibited by a-AI1 but not by a-AI2. The objective of this work was to understand the molecular basis of the specificity of two inhibitors in P. vulgaris (a-AI1 and a-AI2) in relation to a-amylases. Mutants

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Cathcart-Rake, Elizabeth Jane, Lindsey R. Sangaralingham, Nilay Shah, and Aaron Scott Mansfield. "Immunotherapy-related toxicities: More common than originally reported?" Journal of Clinical Oncology 36, no. 34_suppl (2018): 184. http://dx.doi.org/10.1200/jco.2018.36.34_suppl.184.

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184 Background: Population level data regarding incidence of immune-related adverse events (irAE) is lacking. This study evaluated the frequency of irAEs among a large population of patients with non-small cell lung cancer (NSCLC) who received immune checkpoint inhibitors. Methods: Administrative claims data from a large U.S. commercial insurance database (OptumLabs Data Warehouse) were used to retrospectively identify patients with NSCLC who received PD-1 or PD-L1 inhibitors between January 1, 2015 to December 31, 2017. The frequencies of irAEs were reported, identified by having a new medica

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Zhou, Jia-Le, Hao-Han Chen, Jian Xu, et al. "Myricetin Acts as an Inhibitor of Type II NADH Dehydrogenase from Staphylococcus aureus." Molecules 29, no. 10 (2024): 2354. http://dx.doi.org/10.3390/molecules29102354.

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Background: Staphylococcus aureus is a common pathogenic microorganism in humans and animals. Type II NADH oxidoreductase (NDH-2) is the only NADH:quinone oxidoreductase present in this organism and represents a promising target for the development of anti-staphylococcal drugs. Recently, myricetin, a natural flavonoid from vegetables and fruits, was found to be a potential inhibitor of NDH-2 of S. aureus. The objective of this study was to evaluate the inhibitory properties of myricetin against NDH-2 and its impact on the growth and expression of virulence factors in S. aureus. Results: A scre

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Burger, Dylan, Timothy L. Reudelhuber, Aman Mahajan, Kelly Chibale, Edward D. Sturrock, and Rhian M. Touyz. "Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension." Clinical Science 127, no. 1 (2014): 57–63. http://dx.doi.org/10.1042/cs20130808.

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The C-domain selective ACE inhibitor lisW-S reduced blood pressure and AngII levels in hypertensive TtRhRen mice similarly to classical ACE inhibitors and has the potential to avoid undesirable effects on the bradykinin system common to classic ACE inhibitors.

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Carlson, Robert H. "TKI Inhibitor Active in Common and Rare Tumors." Oncology Times 38, no. 11 (2016): 23–25. http://dx.doi.org/10.1097/01.cot.0000484649.13722.19.

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Gross, Stefan David, Tara L. Peters, Michael R. Burkard, et al. "Abstract LB295: ELV-3111, a type 1 pan-RAF inhibitor, that safely combines with MEK inhibitors for enhanced anti-tumor activity in NRAS and BRAF mutant cancers including the most common mechanisms of BRAF inhibitor clinical resistance." Cancer Research 85, no. 8_Supplement_2 (2025): LB295. https://doi.org/10.1158/1538-7445.am2025-lb295.

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Abstract Tumors harboring RAS/RAF mutations represent a significant unmet medical need that is potentially addressable by targeted therapy. Currently approved RAF inhibitors target BRAFV600X mutant cancers via a type 1.5 binding mode (DFG-in, αC-helix out) that effectively inhibits monomeric BRAFV600X, while inducing RAF pathway activation in contexts where RAF signals as a dimer (wildtype, BRAF class II/III and RAS mutant settings). Their inability to inhibit dimeric RAF presents three significant challenges: (1) they are only active against BRAFV600X tumors (2) they induce toxicities due to

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Klei, Herbert E., Kevin Kish, Pin-Fang M. Lin, et al. "X-Ray Crystal Structures of Human Immunodeficiency Virus Type 1 Protease Mutants Complexed with Atazanavir." Journal of Virology 81, no. 17 (2007): 9525–35. http://dx.doi.org/10.1128/jvi.02503-05.

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ABSTRACT Atazanavir, which is marketed as REYATAZ, is the first human immunodeficiency virus type 1 (HIV-1) protease inhibitor approved for once-daily administration. As previously reported, atazanavir offers improved inhibitory profiles against several common variants of HIV-1 protease over those of the other peptidomimetic inhibitors currently on the market. This work describes the X-ray crystal structures of complexes of atazanavir with two HIV-1 protease variants, namely, (i) an enzyme optimized for resistance to autolysis and oxidation, referred to as the cleavage-resistant mutant (CRM);

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Yoshihara, S., K. Kondo, K. Kanaya, et al. "Tumour necrosis factor inhibitor-associated sinusitis." Rhinology journal 52, no. 3 (2014): 246–51. http://dx.doi.org/10.4193/rhino13.074.

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Aim: To describe the features of chronic sinusitis associated with the use of tumour necrosis factor (TNF) inhibitors. Methodology: A retrospective review of the medical records between 2003 and 2011 revealed that five patients had developed chronic sinusitis after the start of TNF inhibitor administration and required rhinological evaluation and treatment. Results: The incidence of refractory sinusitis associated with TNF inhibitors was approximately 2%. Of the five patients identified, four patients were medicated with etanercept and one with infliximab. The maxillary sinus was most commonly

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Lee, Seung-Hwa, Jungchan Park, Rae Woong Park, et al. "Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Cancer: A Population-Based Cohort Study Using a Common Data Model." Diagnostics 12, no. 2 (2022): 263. http://dx.doi.org/10.3390/diagnostics12020263.

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Studies have reported conflicting results on the association between the use of renin-angiotensin-aldosterone system (RAAS) inhibitors and cancer development. We compared the incidence of cancer between patients using RAAS inhibitors and other antihypertensive drugs. This retrospective observational cohort study used data from seven hospitals in Korea that were converted for use in the Observational Medical Outcomes Partnership Common Data Model. A total of 166,071 patients on antihypertensive therapy across the databases of the seven hospitals were divided into two groups according to the use

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Pradeep, Roshini, Afsheen Moshtaghi, Hamza Khan, Ann K. Walenga, Neychelle Rocca, and Andrzej Piotr Kudelka. "Role of proton pump inhibitors in immune checkpoint inhibitor colitis." Journal of Clinical Oncology 42, no. 3_suppl (2024): 743. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.743.

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743 Background: Proton pump inhibitors (PPIs) are known to be beneficial in symptomatic control of gastroesophageal reflux disease and gastritis which can be a common complication of various cancers specifically gastrointestinal (GI) cancers. Microscopic colitis development has been studied to be associated with PPI use. Immune checkpoint Inhibitor (ICI) colitis is a known adverse effect of Inhibitors of Programmed cell death 1 (PD-1) and its ligand (PD-L1). Previous studies have also shown use of PPIs and NSAIDs are common risk factors which can exacerbate ICI Colitis caused by Inhibitors of

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Popovici, Despina Calamar, Ioana Ionita, Mirela Nedelcu, et al. "Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase." Revista de Chimie 70, no. 8 (2019): 3017–20. http://dx.doi.org/10.37358/rc.19.8.7477.

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Chronic myeloid leukaemia is a malignant tumor of pluripotent haemopoetic stem cell, characterized by increase granulocytes with left shift and the presence of the Ph chromosome.Treatment of chronic phase is made with tyrosine kinase inhibitors administered orally and can have secondary effects: haematological and non-haematological. The purpose of this paper is to assess complications of tyrosine kinase inhibitor therapy in chronic phase of chronic myeloid leukemia and establishing correlations with the type of inhibitor used. The study was performed on a total of 140 patients diagnosed with

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Crowley, Erika L., and Melinda J. Gooderham. "Phosphodiesterase-4 Inhibition in the Management of Psoriasis." Pharmaceutics 16, no. 1 (2023): 23. http://dx.doi.org/10.3390/pharmaceutics16010023.

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Psoriasis is a common chronic immune-mediated disease with many comorbidities and impacts on quality of life. Among the treatments for psoriasis, phosphodiesterase-4 (PDE4) inhibitors are emerging with expanding options. PDE4 inhibitors play a pivotal role in the inflammatory cascade by degrading cyclic adenosine monophosphate (cAMP), contributing to pro-inflammatory mediator production. Apremilast, an oral PDE4 inhibitor, is approved for psoriasis. While effective, its adverse effects can limit its utility. Roflumilast, a topical PDE4 inhibitor, was also recently approved for psoriasis and sh

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Park, Hyeong-Kyu, Sang-Joon Park, Soon-Hyo Kwon, Dong-Won Byun, and Kyo-il Suh. "COMPARISON OF RENAL PROTECTIVE EFFECTS BETWEEN SGLT2 INHIBITORS AND DPP4 INHIBITORS IN TYPE 2 DIABETES IN REAL-WORLD CLINICAL PRACTICE." Journal of the ASEAN Federation of Endocrine Societies 38, S3 (2023): 60–61. https://doi.org/10.15605/jafes.038.afes.89.

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INTRODUCTIONRecent prospective randomized studies have shown that sodium-glucose cotransporter 2 inhibitors (SGLT2i) had renal protective effects compared to placebo in patients with type 2 diabetes (T2D). In this study, we compared the renal composite outcomes between patients with T2D treated with SGLT2 inhibitors and those treated with dipeptidyl peptidase 4 inhibitors (DPP4i) using real-world clinical data. METHODOLOGYThis retrospective observational study used the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) database at four different university hospitals (Soonc

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Meeks, Shannon L., John F. Healey, Ernest T. Parker, Rachel T. Barrow, and Pete Lollar. "Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors." Blood 112, no. 4 (2008): 1151–53. http://dx.doi.org/10.1182/blood-2008-01-132639.

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Abstract The antihuman factor VIII (fVIII) C2 domain immune response in hemophilia A mice consists of antibodies that can be divided into 5 groups of structural epitopes and 2 groups of functional epitopes. Groups A, AB, and B consist of classical C2 antibodies that inhibit the binding of fVIII to phospholipid and von Willebrand factor. Groups BC and C contain nonclassical C2 antibodies that block the activation of fVIII by thrombin or factor Xa. Group BC antibodies are the most common and display high specific inhibitory activity and type II kinetics. The C2 epitope groups recognized by 26 po

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Ke, Qiang, and Fa Shu Liang. "Investigation of Application Conditions of Barium/Strontium Scale Inhibitor in Oilfields." Advanced Materials Research 311-313 (August 2011): 1097–101. http://dx.doi.org/10.4028/www.scientific.net/amr.311-313.1097.

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In response to the serious barium / strontium – scale in oilfields, we simulated oilfield conditions and investigated the scale inhibition performance of several common scale inhibitors to barium and strontium, by following the protocol from Evaluation Methods of Anti-Scale Agent for Oilfield Use, Petroleum Gas Standards of People’s Republic of China SY/T 5673. The most effective scale inhibitor CD-1 was screened out. With CD-1 as barium / strontium scale inhibitor in the static anti-scale analytical experiments, the dependence of scale inhibition performance on scale inhibitor concentration,

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SNIPAS, Scott J., Henning R. STENNICKE, Stefan RIEDL, et al. "Inhibition of distant caspase homologues by natural caspase inhibitors." Biochemical Journal 357, no. 2 (2001): 575–80. http://dx.doi.org/10.1042/bj3570575.

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Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor of apoptosis (IAP) family, are thought to be caspase specific. However, caspases are members of the clan of cysteine proteases designated CD, which also includes animal and plant legumains, and the bacterial proteases clostripain, gingipain-R and gingipain-K. Since these proteases have been proposed to have a common mechanism and evolutionary orig

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Zhong, Degang, Evgueni L. Saenko, Midori Shima, Matthew Felch, and Dorothea Scandella. "Some Human Inhibitor Antibodies Interfere With Factor VIII Binding to Factor IX." Blood 92, no. 1 (1998): 136–42. http://dx.doi.org/10.1182/blood.v92.1.136.413k35_136_142.

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Factor VIII (fVIII) functions as a cofactor of factor IXa in the intrinsic pathway of blood coagulation. Its absence or abnormality causes the bleeding disorder hemophilia A. About 23% of hemophiliacs who receive therapeutic fVIII infusions develop antibodies that inhibit its activity. We previously showed by inhibitor neutralization assays that the fVIII A2 and C2 domain polypeptides contain common inhibitor epitopes. Often hemophilic inhibitor plasmas were partially neutralized by C2 and more completely neutralized by fVIII light chain (A3-C1-C2), suggesting the presence of an additional maj

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Safira, Faradilla, Fachri Muhammad, and Bonita Dilasari. "Shrimp shell waste as a potential corrosion inhibitor for mild steel in acid solution." E3S Web of Conferences 543 (2024): 03003. http://dx.doi.org/10.1051/e3sconf/202454303003.

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Application of corrosion inhibitor is a common method to minimize corrosion reaction of steel in aqueous environments. Research for an effective eco-friendly corrosion inhibitor is required due to the toxicity issues of the most commercially available corrosion inhibitors. Many recent studies have shown that various food waste can be utilized as corrosion inhibitors. Extracting inhibitor compounds from food waste is definitely low cost, less harm, and environmentally beneficial. One example of corrosion inhibitor derived from food waste is a water-soluble chitosan (WSC) inhibitor, which can be

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Liu, Guoqing, Zhenping Chen, Wenman Wu, and Runhui Wu. "Development and desensitization therapy of high-response factor VIII inhibitors with severe allergic reaction in a moderate hemophilia A patient." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842098025. http://dx.doi.org/10.1177/2058738420980259.

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Neutralizing antibodies (inhibitors) against factor VIII/IX (FVIII/FIX) poses a serious and challenging complication in the hemophilia treatment. Allergic reaction is more common in hemophilia B and always companion with FIX inhibitors, but it is rare in hemophilia A (HA). So far only few cases demonstrated FVIII-specific allergic response in hemophilia A. Coexistence of allergic reactions with inhibitors was contraindicated for immune tolerance induction (ITI) regimen which is the only proven therapy to eliminate inhibitor. We report a rare case of a 11-year-old boy with moderate HA who devel

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Towheed, Shahrukh, and Evan Wilson. "Salmonella Septic Arthritis and Osteomyelitis in Patients Receiving Tumor Necrosis Factor Alpha Inhibitors." Journal of Rheumatology 52, Suppl 2 (2025): 108.2–108. https://doi.org/10.3899/jrheum.2025-0314.133.

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ObjectivesTumor necrosis factor (TNF) alpha inhibitor therapies are used worldwide to treat a variety of rheumatic diseases. However, they are also associated with serious infections. This review summarizes and critically appraises the literature surrounding Salmonella musculoskeletal infections in patients receiving TNF alpha inhibitors. The objective of this review is to raise awareness of the risk of Salmonella septic arthritis and osteomyelitis in patients receiving TNF alpha inhibitors. Potential pathophysiologic and immunologic mechanisms are discussed.MethodsThe MEDLINE, EMBASE, and Goo

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Ma, Jinyuan. "Rapidly developing colitis induced by combination therapy of lenvatinib and anti-PD-1 antibody in the treatment of hepatocellular carcinoma." Clinical Imaging and Case Reports 5, no. 1 (2023): 1–5. http://dx.doi.org/10.52338/cicasrep.2022.1009.

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Although diarrhea caused by immune checkpoint inhibitors (ICIs) or tyrosine kinase inhibitor (TKI) are common, server colitis caused by tyrosine kinase inhibitor (TKI) combined with anti-PD-1 has not been paid attention to. The combination of lenvatinib and anti-PD-1 antibody has been applied for an effort for HCC treatment. We reported two cases of initially lenvatinib induced mild diarrhea while fast developed into rather severe colitis after the first dose of anti-PD-1.

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Xiao, Gang, Zhiyuan Liu, Xuan Gao, et al. "Immune checkpoint inhibitors for brain metastases in non-small-cell lung cancer: from rationale to clinical application." Immunotherapy 13, no. 12 (2021): 1031–51. http://dx.doi.org/10.2217/imt-2020-0262.

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Brain metastases (BM) is common in non-small-cell lung cancer (NSCLC) patients. Immune checkpoint inhibitors (ICIs) have gradually become a routine treatment for NSCLC BM patients. Currently, three PD-1 inhibitors (pembrolizumab, nivolumab and cemiplimab), one PD-L1 inhibitor (atezolizumab) and one CTLA-4 inhibitor (ipilimumab) have been approved for the first-line treatment of metastatic NSCLC. It is still controversial whether PD-L1, tumor infiltrating lymphocytes, and tumor mutation burden can be used as predictive biomarkers for immune checkpoint inhibitors in NSCLC patients with BM. In ad

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Jermakowicz, Anna, Vasileios Stathias, Robert Suter, James Duncan, Stephan Schürer, and Nagi Ayad. "GENE-36. INTEGRATING TRANSCRIPTOMICS AND KINOMICS IDENTIFIES SYNERGISTIC DRUG COMBINATIONS FOR GLIOBLASTOMA TREATMENT." Neuro-Oncology 21, Supplement_6 (2019): vi105. http://dx.doi.org/10.1093/neuonc/noz175.438.

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Abstract Glioblastoma (GBM) is the most common and malignant adult brain tumor. Despite years of research, few advancements have been made in its management. One promising avenue of research has been treatment with BRD4 inhibitors, which decrease oncogene expression in GBM cells. However, resistance to these inhibitors is rapidly acquired. Kinome reprogramming is thought to underlie this resistance, suggesting a need for combination therapy with kinase inhibitors. The goal of this study is to determine whether transcriptomic and kinomic profiling of GBM tumors will identify synergistic drug pa

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Oldenburg, J., J. K. Picard, R. Schwaab, H. H. Brackmann, E. G. D. Tuddenham, and E. Simpson. "HLA Genotype of Patients with Severe Haemophilia A due to Intron 22 Inversion with and without Inhibitors of Factor VIII." Thrombosis and Haemostasis 77, no. 02 (1997): 238–42. http://dx.doi.org/10.1055/s-0038-1655945.

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SummaryMolecular genetic studies have shown that development of antibodies to factor VIII (inhibitors) occurs most frequently in patients with severe haemophilia due to major gene lesions including inversions, stop codons and large deletions. Previous studies of HLA type were performed on inhibitor and non-inhibitor patients with diverse uncharacterised mutations which may have confounded detection of significant associations. We therefore selected a group of patients with a single mutation type, the prevalent intron 22 inversion, with or without inhibitors, to determine HLA genotype. Seventy-

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&NA;. "ACE inhibitor-induced cough more common in Black patients." Reactions Weekly &NA;, no. 636 (1997): 5. http://dx.doi.org/10.2165/00128415-199706360-00013.

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Vagnerova, Kamila, R. Noppens, P. D. Hurn, J. R. Kirsch, and A. Bhardwaj. "COMMON NEUROPROTECTIVE MECHANISM 1 RECEPTOR AGONIST AND INOS INHIBITOR." Critical Care Medicine 32, Supplement (2004): A98. http://dx.doi.org/10.1097/00003246-200412001-00353.

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Nguyen, Cuong, and Seung Kee Han. "Synchronization of toggle switches coupled through a common inhibitor." EPL (Europhysics Letters) 90, no. 1 (2010): 10010. http://dx.doi.org/10.1209/0295-5075/90/10010.

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Falvello, Virginia, Daria Brinzevich, Alex Bryant, and Michael D. Green. "Effect of common medications on immune checkpoint inhibitor efficacy." Journal of Clinical Oncology 42, no. 16_suppl (2024): e14710-e14710. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14710.

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e14710 Background: Previous studies have suggested that certain common medications could impact immune checkpoint inhibitor (ICI) efficacy and survival. These studies lacked non-ICI control groups, raising the possibility that survival differences could be explained by confounding. Methods: We developed a pan-cancer cohort of 27,998 patients who received ICIs in the national Veterans Health Administration (VHA) from 2010 to 2023. ICI patients were matched to 66,488 historical control patients treated with chemotherapy or targeted therapy before initial ICI regulatory approval in each cancer. W

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Li, Wenzhi, Xin Li, Zhaoxu Han, Xinru Jin, and Cong Liu. "Research Progress of Solid Scale Inhibitors Used in Oilfield." Academic Journal of Science and Technology 12, no. 3 (2024): 130–33. http://dx.doi.org/10.54097/t684t441.

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Solid scale inhibitor has the advantages of long operation time, low operating cost and simple operation, and has broad application prospects in oil field production at home and abroad. In this paper, the basic components, preparation technology and common curing carrier of solid scale inhibitors are introduced, and the research and application progress of solid scale inhibitors are introduced.

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Seeber, Laura M. S., Ronald P. Zweemer, René H. M. Verheijen, and Paul J. van Diest. "Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management." Obstetrics and Gynecology International 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/580971.

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In the Western world, endometrial cancer (EC) is the most common malignant tumor of the female genital tract. Solid tumors like EC outgrow their vasculature resulting in hypoxia. Tumor hypoxia is important because it renders an aggressive phenotype and leads to radio- and chemo-therapy resistance. Hypoxia-inducible factor-1 (HIF-1) plays an essential role in the adaptive cellular response to hypoxia and is associated with poor clinical outcome in EC. Therefore, HIF-1 could be an attractive therapeutic target. Selective HIF-1 inhibitors have not been identified. A number of nonselective inhibit

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