Dissertations / Theses on the topic 'Comparative methody'

This diploma thesis deals with desigantion of usual price of ten residential units in Jemnice and Moravské Budějovice. Valuation is done with direct comparison and with comparative methody by valid price regulation. Constituent part of this thesis is analysis effect of location on the usual price of selected locality.

Globalization is not only a transformation of the economical world, but also of geographical space in its totality. The local territories participate in this transformation. To study and compare their evolution can help us to analyze the globalisation as well as its construction, its effects and in its limits, as the existence of social and political dynamics which are not globalized. This reflexion rests on case studies in Peru, made in collaboration with other French and Peruvian researchers.
La globalización no es solo una transformación del mundo económico sino también del espacio geográfico en su conjunto. Los territorios locales participan en esta transformación. Estudiar y comparar sus evoluciones nos puede ayudar a analizar tanto la globalización, en su construcción, en sus efectos y en sus límites, como la existencia de dinámicas sociales y políticas que no son globalizadas. La reflexión se fundamenta sobre casos estudiados en el Perú, en colaboración con otros investigadores franceses y peruanos.

Advancements in media technologies have resulted in increased student usage causing teachers to struggle to be able to engage and hold student’s interest in a typical classroom. As students’ needs change, the field of education changes. One strategy that is gaining in popularity among teachers is the implementation of the “flipped classroom” also known as the “inverted classroom” or “reverse instruction” - a method incorporates technology to “flip” or “reverse” what is typically done in class with what is typically done as homework. Through teacher interviews of eight core teachers, this study attempts to discover teacher perceptions of the use of this method. Results of the study reveal that perceptions of the method are more positive among teachers who typically use lecture as a primary mode of information dissemination.

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.
Includes bibliographical references (p. 161-163).
Robust parameter design is an engineering methodology intended as a cost effective approach to improve the quality of products, processes and systems. Control factors are those system parameters that can be easily controlled and manipulated. Noise factors are those system parameters that are difficult and/or costly to control and are presumed uncontrollable. Robust parameter design involves choosing optimal levels of the controllable factors in order to obtain a target or optimal response with minimal variation. Noise factors bring variability into the system, thus affecting the response. The aim is to properly choose the levels of control factors so that the process is robust or insensitive to the variation caused by noise factors. Robust parameter design methods are used to make systems more reliable and robust to incoming variations in environmental effects, manufacturing processes and customer usage patterns. However, robust design can become expensive, time consuming, and/or resource intensive. Thus research that makes robust design less resource intensive and requires less number of experimental runs is of great value. Robust design methodology can be expressed as multi-response optimization problem.
(cont.) The objective functions of the problem being: maximizing reliability and robustness of systems, minimizing the information and/or resources required for robust design methodology, and minimizing the number of experimental runs needed. This thesis discusses various noise factor strategies which aim to reduce number of experimental runs needed to improve quality of system. Compound Noise and Take-The-Best-Few Noise Factors Strategy are such noise factor strategies which reduce experimental effort needed to improve reliability of systems. Compound Noise is made by combing all the different noise factors together, irrespective of the number of noise factors. But such a noise strategy works only for the systems which show effect sparsity. To apply the Take-The-Best-Few Noise Factors Strategy most important noise factors in system's noise factor space are found. Noise factors having significant impact on system response variation are considered important. Once the important noise factors are identified, they are kept independent in the noise factor array. By selecting the few most important noise factors for a given system, run size of experiment is minimized.
(cont.) Take-The-Best-Few Noise Factors Strategy is very effective for all kinds of systems irrespective of their effect sparsity. Generally Take-The-Best-Few Noise Factors Strategy achieves nearly 80% of the possible improvement for all systems. This thesis also tries to find the influence of correlation and variance of induced noise on quality of system. For systems that do not contain any significant three-factor interactions correlation among noise factors can be neglected. Hence amount of information needed to improve the quality of systems is reduced.
by Jagmeet Singh.
Ph.D.

CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior
Objetivou-se com o seguinte trabalho determinar as exigÃncias nutricionais de energia e proteÃna em ovinos Somalis Brasileira. Utilizou-se 48 ovinos Somalis Brasileira em crescimento, nÃo-castrados, com idade e peso corporal (PC) mÃdio de 60 dias e 13,47  1,76 kg, respectivamente. ApÃs um perÃodo de adaptaÃÃo de 20 dias, oito animais foram abatidos e utilizados como referÃncia para estimativas do peso de corpo vazio (PCVZ) e da composiÃÃo corporal inicial dos demais animais. Os animais remanescentes foram distribuÃdos em um delineamento em blocos casualizados, sendo os tratamentos, raÃÃes contendo diferentes nÃveis de energia metabolizÃvel (1,18; 2,07; 2,25; 2,42 e 2,69 Mcal/kg MS), com oito repetiÃÃes. O peso de abate foi determinado quando a mÃdia de peso dos animais de um dos cinco tratamentos atingiu 28 kg. A exigÃncia lÃquida de energia para mantenÃa foi estimado extrapolando-se a equaÃÃo de regressÃo do logaritmo da produÃÃo de calor, em funÃÃo do consumo de energia metabolizÃvel (CEM) para o nÃvel zero de CEM. A excreÃÃo diÃria de nitrogÃnio (N) foi estimada extrapolando-se a equaÃÃo de regressÃo de consumo de N (g/kg PC0,75/dia) em funÃÃo da retenÃÃo de N (g/kg PC0,75/dia) para o consumo zero. Foram ajustadas equaÃÃes de regressÃo do logaritmo do conteÃdo de gordura, energia e proteÃna em funÃÃo do logaritmo do PCVZ dos animais. A concentraÃÃo de energia lÃquida da dieta para mantenÃa, foi obtida dividindo-se a produÃÃo de calor em jejum, pelo CMS para manter o equilÃbrio de energia, expresso em g de MS/kg PCVZ0,75. A validaÃÃo do modelo SRNS foi realizada atravÃs do ajuste de modelo de regressÃo linear simples entre os valores preditos (variÃvel independente) e observados (variÃvel dependente), as variÃveis analisadas foram CMS e GPC. A composiÃÃo quÃmica corporal foi determinada utilizando a composiÃÃo da meia carcaÃa direita, assim como uma amostra da seÃÃo HH, obtida da meia carcaÃa esquerda. Na meia-carcaÃa esquerda resfriada, retirou-se o corte da seÃÃo HH, pela secÃÃo transversal da 9a-10a-11a costelas no ponto correspondente a 61,5% da distÃncia entre a vÃrtebra seccionada e o inÃcio da cartilagem da 12a costela, em seguida, a seÃÃo HH foi moÃda em moedor de carne industrial e homogeneizada. O ganho mÃdio diÃrio e o ganho de peso de corpo vazio aumentaram linearmente com o aumento dos nÃveis de energia metabolizÃveis. Jà o peso corporal final, peso corporal ao abate, peso de corpo vazio, consumo de matÃria seca e consumo de energia metabolizÃvel apresentaram efeito quadrÃtico (P <0,001) com o aumento do nÃvel de energia. O teor de energia e de gordura de PCVZ dos animais aumentou de 2,77 Mcal/kg e 209,17 g/kg para 3,47 Mcal/kg e 294,08 g/kg de PCVZ, respectivamente, e o PC aumentou de 13,00 para 28,70 kg. O consumo de nitrogÃnio apresentou efeito quadrÃtico, com ponto de mÃxima de 2,59 Mcal/kg MS de energia metabolizÃvel, correspondendo ao consumo mÃximo de N de 2,90 g/kg PC0,75/dia. Jà para o nitrogÃnio retido diariamente, observou-se resposta linear crescente com o aumento nos nÃveis de energia metabolizÃvel nas dietas. Observou-se uma diminuiÃÃo da quantidade de proteÃna no corpo vazio dos animais com o aumento do PCVZ, passando de 143,71 para 122,52 g/kg PCVZ, quando os animais aumentaram o peso corporal de 13,00 para 28,70 kg. A excreÃÃo diÃria de N foi estimada em 0,128 g/kg PC0,75/dia. A composiÃÃo corporal de ovinos Somalis Brasileira varia de 538,28 a 593,93 g/kg de PCVZ para Ãgua, 228,17 a 353,13 g/kg de PCVZ para gordura, 114,53 a 157,93 g/kg de PCVZ para poteÃna e 17,94 a 31,68 g/kg de PCVZ de matÃria mineral, para dietas contendo 1,18 a 2,69 Mcal/kg de MS, respectivamente. A exigÃncia lÃquida de energia para mantenÃa à 45,63 g/kg PCVZ0,75/dia. O aumento no peso dos animais de 13,00 para 28,70 kg PC eleva as deposiÃÃes de gordura de 283,75 para 398,93 g/kg GPCVZ e energia de 3,42 para 4,30 Mcal/kg GPCVZ. A exigÃncia lÃquida de proteÃna para mantenÃa à 0,80 g/kg PC0,75/dia, havendo uma diminuiÃÃo da exigÃncia lÃquida de proteÃna para GPCVZ de 119,72 para 102,07 g/kg GPCVZ, conforme o peso corporal aumenta de 13,00 para 28,70 kg. A eficiÃncia de uso da energia metabolizÃvel para mantenÃa à de 0,67. Jà a eficiÃncia de uso da energia metabolizÃvel para ganho varia de 1,85 a 0,43 para dietas contendo 1,18 a 2,69 Mcal/hg MS respectivamente. As exigÃncias lÃquidas de energia e proteÃna elevam-se com o aumento do peso corporal e aumento do ganho de peso corporal dos ovinos Somalis Brasileira. O modelo Small Ruminant Nutrition Systems à sensÃvel para predizer o consumo de matÃria seca, entretanto, subestimou em 5,18% o ganho mÃdio diÃrio de peso corporal. A seÃÃo HH estimou satisfatoriamente a composiÃÃo quÃmica de Ãgua, proteÃna e gordura na carcaÃa e no corpo vazio, enquanto o teor de minerais foi subestimado em torno de 27,07% na carcaÃa e 14,91% no corpo vazio. Os teores de Ãgua, proteÃna bruta e gordura da carcaÃa podem ser preditos pela seÃÃo HH. Por fim, a composiÃÃo quÃmica da seÃÃo HH pode ser utilizada em substituiÃÃo à composiÃÃo quÃmica da carcaÃa para predizer composiÃÃo quÃmica do corpo vazio em ovinos Somalis Brasileira.
Objetivou-se com o seguinte trabalho determinar as exigÃncias nutricionais de energia e proteÃna em ovinos Somalis Brasileira. Utilizou-se 48 ovinos Somalis Brasileira em crescimento, nÃo-castrados, com idade e peso corporal (PC) mÃdio de 60 dias e 13,47  1,76 kg, respectivamente. ApÃs um perÃodo de adaptaÃÃo de 20 dias, oito animais foram abatidos e utilizados como referÃncia para estimativas do peso de corpo vazio (PCVZ) e da composiÃÃo corporal inicial dos demais animais. Os animais remanescentes foram distribuÃdos em um delineamento em blocos casualizados, sendo os tratamentos, raÃÃes contendo diferentes nÃveis de energia metabolizÃvel (1,18; 2,07; 2,25; 2,42 e 2,69 Mcal/kg MS), com oito repetiÃÃes. O peso de abate foi determinado quando a mÃdia de peso dos animais de um dos cinco tratamentos atingiu 28 kg. A exigÃncia lÃquida de energia para mantenÃa foi estimado extrapolando-se a equaÃÃo de regressÃo do logaritmo da produÃÃo de calor, em funÃÃo do consumo de energia metabolizÃvel (CEM) para o nÃvel zero de CEM. A excreÃÃo diÃria de nitrogÃnio (N) foi estimada extrapolando-se a equaÃÃo de regressÃo de consumo de N (g/kg PC0,75/dia) em funÃÃo da retenÃÃo de N (g/kg PC0,75/dia) para o consumo zero. Foram ajustadas equaÃÃes de regressÃo do logaritmo do conteÃdo de gordura, energia e proteÃna em funÃÃo do logaritmo do PCVZ dos animais. A concentraÃÃo de energia lÃquida da dieta para mantenÃa, foi obtida dividindo-se a produÃÃo de calor em jejum, pelo CMS para manter o equilÃbrio de energia, expresso em g de MS/kg PCVZ0,75. A validaÃÃo do modelo SRNS foi realizada atravÃs do ajuste de modelo de regressÃo linear simples entre os valores preditos (variÃvel independente) e observados (variÃvel dependente), as variÃveis analisadas foram CMS e GPC. A composiÃÃo quÃmica corporal foi determinada utilizando a composiÃÃo da meia carcaÃa direita, assim como uma amostra da seÃÃo HH, obtida da meia carcaÃa esquerda. Na meia-carcaÃa esquerda resfriada, retirou-se o corte da seÃÃo HH, pela secÃÃo transversal da 9a-10a-11a costelas no ponto correspondente a 61,5% da distÃncia entre a vÃrtebra seccionada e o inÃcio da cartilagem da 12a costela, em seguida, a seÃÃo HH foi moÃda em moedor de carne industrial e homogeneizada. O ganho mÃdio diÃrio e o ganho de peso de corpo vazio aumentaram linearmente com o aumento dos nÃveis de energia metabolizÃveis. Jà o peso corporal final, peso corporal ao abate, peso de corpo vazio, consumo de matÃria seca e consumo de energia metabolizÃvel apresentaram efeito quadrÃtico (P <0,001) com o aumento do nÃvel de energia. O teor de energia e de gordura de PCVZ dos animais aumentou de 2,77 Mcal/kg e 209,17 g/kg para 3,47 Mcal/kg e 294,08 g/kg de PCVZ, respectivamente, e o PC aumentou de 13,00 para 28,70 kg. O consumo de nitrogÃnio apresentou efeito quadrÃtico, com ponto de mÃxima de 2,59 Mcal/kg MS de energia metabolizÃvel, correspondendo ao consumo mÃximo de N de 2,90 g/kg PC0,75/dia. Jà para o nitrogÃnio retido diariamente, observou-se resposta linear crescente com o aumento nos nÃveis de energia metabolizÃvel nas dietas. Observou-se uma diminuiÃÃo da quantidade de proteÃna no corpo vazio dos animais com o aumento do PCVZ, passando de 143,71 para 122,52 g/kg PCVZ, quando os animais aumentaram o peso corporal de 13,00 para 28,70 kg. A excreÃÃo diÃria de N foi estimada em 0,128 g/kg PC0,75/dia. A composiÃÃo corporal de ovinos Somalis Brasileira varia de 538,28 a 593,93 g/kg de PCVZ para Ãgua, 228,17 a 353,13 g/kg de PCVZ para gordura, 114,53 a 157,93 g/kg de PCVZ para poteÃna e 17,94 a 31,68 g/kg de PCVZ de matÃria mineral, para dietas contendo 1,18 a 2,69 Mcal/kg de MS, respectivamente. A exigÃncia lÃquida de energia para mantenÃa à 45,63 g/kg PCVZ0,75/dia. O aumento no peso dos animais de 13,00 para 28,70 kg PC eleva as deposiÃÃes de gordura de 283,75 para 398,93 g/kg GPCVZ e energia de 3,42 para 4,30 Mcal/kg GPCVZ. A exigÃncia lÃquida de proteÃna para mantenÃa à 0,80 g/kg PC0,75/dia, havendo uma diminuiÃÃo da exigÃncia lÃquida de proteÃna para GPCVZ de 119,72 para 102,07 g/kg GPCVZ, conforme o peso corporal aumenta de 13,00 para 28,70 kg. A eficiÃncia de uso da energia metabolizÃvel para mantenÃa à de 0,67. Jà a eficiÃncia de uso da energia metabolizÃvel para ganho varia de 1,85 a 0,43 para dietas contendo 1,18 a 2,69 Mcal/hg MS respectivamente. As exigÃncias lÃquidas de energia e proteÃna elevam-se com o aumento do peso corporal e aumento do ganho de peso corporal dos ovinos Somalis Brasileira. O modelo Small Ruminant Nutrition Systems à sensÃvel para predizer o consumo de matÃria seca, entretanto, subestimou em 5,18% o ganho mÃdio diÃrio de peso corporal. A seÃÃo HH estimou satisfatoriamente a composiÃÃo quÃmica de Ãgua, proteÃna e gordura na carcaÃa e no corpo vazio, enquanto o teor de minerais foi subestimado em torno de 27,07% na carcaÃa e 14,91% no corpo vazio. Os teores de Ãgua, proteÃna bruta e gordura da carcaÃa podem ser preditos pela seÃÃo HH. Por fim, a composiÃÃo quÃmica da seÃÃo HH pode ser utilizada em substituiÃÃo à composiÃÃo quÃmica da carcaÃa para predizer composiÃÃo quÃmica do corpo vazio em ovinos Somalis Brasileira.
The objective of the following work to determine the nutritional requirements of energy and protein in Brazilian Somali sheep. We used 48 sheep Brazilian Somali growing, non-castrated, age and body weight (BW) average of 60 days and 13.47 Â 1.76 kg respectively. After a 20 day adaptation period, eight animals were slaughtered and used as a reference for estimates of empty body weight (EBW) and initial body composition of other animals. The remaining animals were distributed in a randomized block design, with the treatments, diets with different levels of metabolizable energy (1.18; 2.07; 2.25; 2.42 and 2.69 Mcal/kg DM), with eight repetitions. The weight of slaughter animals was determined when the weight average of the five treatments was 28 kg. The net energy requirement for maintenance was estimated extrapolating the logarithmic regression equation of heat production, depending on the metabolizable energy intake (MEI) to the zero level of MEI. The daily excretion of nitrogen (N) was estimated by extrapolating to N consumption regression equation (g/BW0.75 kg/day) as a function of the N retention (g/BW 0.75 kg/day) for consumption zero. They were adjusted regression of log equations fat content, protein and energy in the logarithm of EBW animals. The concentration of net energy for maintenance diet was obtained by dividing the heat production in fasting, the DMI to maintain energy balance in g DM/kg EBW0.75. The validation of the SRNS model was performed using the simple linear regression model fit between the predicted values (independent variable) and observed (dependent variable), variables were analyzed DMI and BWG. The body composition was determined using the composition of the right half carcass, as well as a sample of the section HH, obtained from the left crankcase half. In middle housing cooled left, retreated cutting the section HH, the cross section of the 9th-10th-11th rib at the point corresponding to 61.5% of the distance between the sectioned vertebrae and the beginning of the 12th rib cartilage in then, the HH section was ground in grinder industrial and homogenised meat. The average daily gain and empty body weight gain increased linearly with increasing metabolizable energy levels. But the final body weight, body weight at slaughter, empty body weight, dry matter intake and metabolizable energy intake showed a quadratic effect (P<0.001) with increasing energy level. Energy and fat EBW of the animals increased from 2.77 Mcal/kg to 209.17 g/kg to 3.47 Mcal/kg to 294.08 g/kg EBW, respectively, and increased the BW 13.00 to 28.70 kg. Consumption of nitrogen showed quadratic effect with point of maximum of 2.59 Mcal/kg DM of metabolizable energy, corresponding to the maximum consumption of N of 2.90 g/kg BW0.75/day. As for the nitrogen retained daily, there was a positive linear correlation with the increase in metabolizable energy levels in the diets. There was a decreased amount of protein in the empty body of animals with increased EBW, from 143.71 to 122.52 g/kg EBW, when the animals increased the body weight of 13.00 to 28.70 kg. The daily excretion of N was estimated at 0.128 g/BW0.75 kg/day. The body composition of Brazilian Somali sheep ranges from 538.28 to 593.93 g/kg EBW for water, from 228.17 to 353.13 g/kg EBW for fat, 114.53 to 157.93 g/kg EBW for protein and from 17.94 to 31.68 g/kg of EBW of mineral matter, for diets containing 1.18 to 2.69 Mcal/kg DM, respectively. The net energy requirement for maintenance is 45.63 g/kg EBW0.75/day. The increase in animal weight of 13.00 to 28.70 kg BW increases the deposition of fat from 283.75 to 398.93 g/kg EBW and energy of 3.42 to 4.30 Mcal/kg EBW. The protein requirement for maintenance is 0.80 g/BW0.75 kg/day, with a decreased protein requirement for EBW of 119.72 to 102.07 g/kg EBW, as the weight increases by 13.00 to 28.70 kg. The use efficiency of metabolizable energy for maintenance is 0.67. Already use efficiency of metabolizable energy for gain varies from 1.85 to 0.43 for diets containing 1.18 to 2.69 Mcal/kg DM, respectively. The net requirements of energy and protein increase with increasing body weight and increase in body weight gain of Brazilian Somali sheep. The model Small Ruminant Nutrition Systems is sensitive to predict dry matter intake, however, underestimated in 5.18% the average daily weight gain. The section HH satisfactorily estimated the chemical composition of water, protein and fat in the carcass and empty body, while the mineral content was underestimated around 27.07% 14.91% housing and empty body. The water content, crude protein and carcass fat can be predicted by section HH. Finally, the chemical composition of section HH can be used to replace the chemical composition of the carcass to predict chemical composition of empty body in Brazilian Somalis sheep.
The objective of the following work to determine the nutritional requirements of energy and protein in Brazilian Somali sheep. We used 48 sheep Brazilian Somali growing, non-castrated, age and body weight (BW) average of 60 days and 13.47 Â 1.76 kg respectively. After a 20 day adaptation period, eight animals were slaughtered and used as a reference for estimates of empty body weight (EBW) and initial body composition of other animals. The remaining animals were distributed in a randomized block design, with the treatments, diets with different levels of metabolizable energy (1.18; 2.07; 2.25; 2.42 and 2.69 Mcal/kg DM), with eight repetitions. The weight of slaughter animals was determined when the weight average of the five treatments was 28 kg. The net energy requirement for maintenance was estimated extrapolating the logarithmic regression equation of heat production, depending on the metabolizable energy intake (MEI) to the zero level of MEI. The daily excretion of nitrogen (N) was estimated by extrapolating to N consumption regression equation (g/BW0.75 kg/day) as a function of the N retention (g/BW 0.75 kg/day) for consumption zero. They were adjusted regression of log equations fat content, protein and energy in the logarithm of EBW animals. The concentration of net energy for maintenance diet was obtained by dividing the heat production in fasting, the DMI to maintain energy balance in g DM/kg EBW0.75. The validation of the SRNS model was performed using the simple linear regression model fit between the predicted values (independent variable) and observed (dependent variable), variables were analyzed DMI and BWG. The body composition was determined using the composition of the right half carcass, as well as a sample of the section HH, obtained from the left crankcase half. In middle housing cooled left, retreated cutting the section HH, the cross section of the 9th-10th-11th rib at the point corresponding to 61.5% of the distance between the sectioned vertebrae and the beginning of the 12th rib cartilage in then, the HH section was ground in grinder industrial and homogenised meat. The average daily gain and empty body weight gain increased linearly with increasing metabolizable energy levels. But the final body weight, body weight at slaughter, empty body weight, dry matter intake and metabolizable energy intake showed a quadratic effect (P<0.001) with increasing energy level. Energy and fat EBW of the animals increased from 2.77 Mcal/kg to 209.17 g/kg to 3.47 Mcal/kg to 294.08 g/kg EBW, respectively, and increased the BW 13.00 to 28.70 kg. Consumption of nitrogen showed quadratic effect with point of maximum of 2.59 Mcal/kg DM of metabolizable energy, corresponding to the maximum consumption of N of 2.90 g/kg BW0.75/day. As for the nitrogen retained daily, there was a positive linear correlation with the increase in metabolizable energy levels in the diets. There was a decreased amount of protein in the empty body of animals with increased EBW, from 143.71 to 122.52 g/kg EBW, when the animals increased the body weight of 13.00 to 28.70 kg. The daily excretion of N was estimated at 0.128 g/BW0.75 kg/day. The body composition of Brazilian Somali sheep ranges from 538.28 to 593.93 g/kg EBW for water, from 228.17 to 353.13 g/kg EBW for fat, 114.53 to 157.93 g/kg EBW for protein and from 17.94 to 31.68 g/kg of EBW of mineral matter, for diets containing 1.18 to 2.69 Mcal/kg DM, respectively. The net energy requirement for maintenance is 45.63 g/kg EBW0.75/day. The increase in animal weight of 13.00 to 28.70 kg BW increases the deposition of fat from 283.75 to 398.93 g/kg EBW and energy of 3.42 to 4.30 Mcal/kg EBW. The protein requirement for maintenance is 0.80 g/BW0.75 kg/day, with a decreased protein requirement for EBW of 119.72 to 102.07 g/kg EBW, as the weight increases by 13.00 to 28.70 kg. The use efficiency of metabolizable energy for maintenance is 0.67. Already use efficiency of metabolizable energy for gain varies from 1.85 to 0.43 for diets containing 1.18 to 2.69 Mcal/kg DM, respectively. The net requirements of energy and protein increase with increasing body weight and increase in body weight gain of Brazilian Somali sheep. The model Small Ruminant Nutrition Systems is sensitive to predict dry matter intake, however, underestimated in 5.18% the average daily weight gain. The section HH satisfactorily estimated the chemical composition of water, protein and fat in the carcass and empty body, while the mineral content was underestimated around 27.07% 14.91% housing and empty body. The water content, crude protein and carcass fat can be predicted by section HH. Finally, the chemical composition of section HH can be used to replace the chemical composition of the carcass to predict chemical composition of empty body in Brazilian Somalis sheep.

Comparative studies of bacterial genomes, now counting in the hundreds, generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with graphic visualization of genomic properties was developed - GenComp. The software was applied to studies of obligate intracellular bacteria. In all studies, ORFs were extracted and grouped into ORF-families. Based on gene order synteny, orthologous clusters of core genes and variable spacer ORFs were identified and extracted for alignments and computation of substitution frequencies. The software was applied to the genomes of six Chlamydia trachomatis strains to identify the most rapidly evolving genes. Five genes were chosen for genotyping, and close to a 3-fold higher discrimination capacity was achieved than that of serotypes. With GenComp as the backbone, a massive comparative analysis were performed on the variable gene set in the Rickettsiaceae, which includes Rickettsia prowazekii and Orientia tsutsugamushi, the agents of epidemic and scrub typhus, respectively. O. tsutsugamushi has the most exceptional bacterial genome identified to date; the 2.2 Mb genome is 200-fold more repeated than the 1.1 Mb R. prowazekii genome due to an extensive proliferation of conjugative type IV secretion systems and associated genes. GenComp identified 688 core genes that are conserved across 7 closely related Rickettsia genomes along with a set of 469 variably present genes with homologs in other species. The analysis indicates that up to 70% of the extensively degraded and variably present genes represent mobile genetic elements and genes putatively acquired by horizontal gene transfer. This explains the paradox of the high pseudogene load in the small Rickettsia genomes. This study demonstrates that GenComp provides an efficient system for pseudogene identification and may help distinguish genes from spurious ORFs in the many pan-genome sequencing projects going on worldwide.

The individual functional analysis (FA) is the most widely used method to identify variables that influence the occurrence of problem behavior. Researchers often modify the FA after the analysis reveals undifferentiated responding. The interview-informed synthesized contingency analysis (IISCA) is one of the most substantial variations of the FA that builds upon the FA modifications. We evaluated the use of the two different functional analytic methods, the FA and IISCA, and the subsequent function-based treatment to reduce problem behavior for three children with autism spectrum disorder (ASD). The individual FA and the IISCA demonstrated differentiated responding for all participants. The treatment based on the results from the traditional FA was effective for all children. We discuss the implications of these findings.

Dissertação para obtenção do Grau de Mestre em Engenharia Electrotécnica e de Computadores
The main objective of this dissertation is to perform a Comparative Analysis of different Multicriteria Decision Making Methods applied to real-world problems, in order to produce relevant information to enable the incorporation of those methods on computational platforms. The current document presents a simple case study concerning a decision support application targeted for a real problem regarding retrofitting alternatives of a building with energy efficiency impact. The application process was started with the selection of two Multicriteria Decision Making Methods guided by a preexisting framework, and resulted in the choice of AHP and PROMETHEE II methodologies. These two methods were then combined with three different decision maker profiles (Conservative, Moderate and Aggressive) created by means of risk assessment profiling techniques for portfolio allocation. Afterwards, the chosen decision criteria were disposed in a Risk Pyramid according to their inherent level of risk regarding project evaluation. A match was then performed between the decision maker profiles and each criterion, so as to define a proper set of weights for the decision criteria and preference functions, with corresponding preference and indifference thresholds. Finally, three different sets of results (one for each decision maker profile) were produced using appropriate software, and a Sensitivity Analysis was performed over the criteria to understand their influence on the solution. The general conclusion of this Comparative Analysis is that the increase in the preference modelling ability of the methods brings up the least expected alternatives as recommendations for the decision maker. Besides, we have concluded that the decision profiles that allocate bigger weights to the riskiest criteria are the ones that produce the more dispersed set of results within each method application and within each decision maker profile.

En la presente tesis se aborda el estudio evolutivo del castigo. La tesis se compone de cuatro experimentos: filogenia del castigo funcional (“functional punishment”) (estudio 1); ontogenia de la venganza (“functional spite”) (estudio 2) y filogenia y ontogenia de la emoción Schadenfreude (estudios 3 y 4). En el estudio 1, cuatro parejas de chimpancés jugaron al ultimátum y dictator game de manera iterativa. Nuestro objetivo era ver si se daban rechazos en repartos injustos como recurso para fomentar la futura generosidad del compañero; si los que ofrecían efectivamente variaban su generosidad dependiendo de los rechazos recibidos; si se daba reciprocidad positiva o negativa entre los sujetos participantes y si la generosidad del que ofrecía variaba entre juegos, es decir, dependiendo de la capacidad de respuesta del compañero. En el estudio 2, alrededor de 500 niños de 6 y 10 años jugaron al ultimátum game en una única interacción (one-shot). Nuestro objetivo era ver si los niños rechazaban repartos injustos aunque no pudieran obtener un futuro beneficio derivado de ese rechazo y si los que ofrecían eran capaces de anticipar un posible rechazo y ofrecían de forma generosa desde el principio. También exploramos si la edad y el sexo son factores determinantes en la tasa de rechazos y el comportamiento estratégico en niños. Por último, analizamos si chimpancés y niños de 4.5, 5 y 6 años incurrían gastos para seguir viendo cómo se castigaba a una persona que les había hecho daño previamente antes que para seguir viendo el castigo a una persona que se había portado bien con ellos (estudio 3). El estudio 4 lo llevamos a cabo solo con chimpancés. Repetimos la misma dinámica que en el estudio anterior pero esta vez el sujeto presenciaba cómo los agentes dirigían un daño o beneficio a otro chimpancé. Nuestro objetivo era ver si los chimpancés incurren gastos para disfrutar del castigo ejecutado a agentes que no interaccionaron directamente con ellos. Los estudios con chimpancés se llevaron a cabo en el Wolfgang Köhler Primate Research Center de Leipzig (Alemania) en colaboración con el Max Planck Institute for Evolutionary Anthropology de la misma ciudad. Los estudios con niños se llevaron a cabo en diferentes centros escolares de Cataluña (estudio 1) y en el Max Planck Institute of Human Cognitive and Brain Sciences.
This thesis deals with the evolutionary study of punishment. The thesis consists of four experiments: phylogeny of functional punishment (study 1); ontogeny of revenge (“functional spite”) (study 2) and phylogeny and ontogeny of Schadenfreude (studies 3 and 4). In study 1, four chimpanzee dyads played the ultimatum and dictator games iteratively. Our goal was to see whether there were rejections of uneven distribution as a way to promote proposer’s future generosity; whether proposers consistently changed their behavior towards generosity based on rejections; whether there was positive or negative reciprocity between the members of the dyad and whether the proposr’s generosity varied between games, that is, depending on the recipient’s capacity to respond. In study 2, nearly 500 children aged 6 and 10 played the ultimatum game in a single (one-shot) interaction. Our goal was to see whether children rejected unfair distributions even if they could not obtain future benefits as well as whether the proposers were able to anticipate responder’s potential rejection and offered generously from the very beginning. We also explored whether age and sex were determinant factors for the rejection rate and for the existence of strategic behavior. Finally, we analyzed whether chimpanzees and children (aged 4.5, 5, and 6 years) incurred costs in order to continue watching how an agent who had previously harmed them was punished rather than continue watching an agent who was previously prosocial with them (study 3). Study 4 was only conducted with chimpanzees. We repeated the same procedure of study 3 but this time the subject witnessed how the antisocial and prosocial agents interacted with a conspecific. Our goal was to see whether chimpanzees incurred costs to enjoy watching punishment enacted towards agents who did not directly interact with them. The studies with chimpanzees were carried out at the Wolfgang Köhler Primate Research Center in Leipzig (Germany) in collaboration with the Max Planck Institute for Evolutionary Anthropology located in the same city. The studies with children were carried out in different schools in Catalonia (study 1) and in the Max Planck Institute of Human Cognitive and Brain Sciences.

A consideração da variável ambiental nos processos decisórios do planejamento tem sido um desafio para diversos países. Nesse sentido, a Avaliação Ambiental Estratégica (AAE), instrumento que tem por objetivo inserir questões ambientais no planejamento de políticas, planos e programas, vem se consolidando no cenário internacional e tem sido cada vez mais praticada, inclusive em países em desenvolvimento como o Brasil. Nesse contexto, essa dissertação compara a situação atual da AAE no Brasil em relação à situação apresentada em México, Espanha, Inglaterra, África do Sul e Brasil. Para isso, foi utilizado o método comparativo qualitativo, que avaliou cada um desses sistemas com base em categorias descritivas e seus respectivos critérios de análise. As categorias selecionadas para caracterizar os sistemas de AAE foram Formal/legal, Institucional, Acadêmica e Prática. Os resultados demonstraram que os sistemas de AAE estudados apresentaram padrões diferentes de desenvolvimento e evolução ao longo do tempo. África do Sul, México e Brasil apresentaram evidências de experiências práticas e também interesse institucional que têm motivado a implementação formal desse instrumento nesses países. Contudo ainda apresentam lacunas em relação à estruturação formal e institucional desta ferramenta, afetando a qualidade de suas experiências práticas. Por outro lado, apesar de algumas limitações, os sistemas de AAE de Espanha e Inglaterra se apresentaram mais estruturados e desenvolvidos, fornecendo evidências empíricas sobre a relevância das esferas institucionais e acadêmicas para o seu desenvolvimento. De maneira geral, a comparação realizada nesta pesquisa demonstrou que existem diferentes formatos de sistemas de AAE, de acordo com o país ou contexto no qual é aplicada.
The insertion of environmental issues in decision-making has been a challenge in many countries. Therefore, Strategic Environmental Assessment (SEA), an instrument that aims to embed environmental issues in the planning of policies, plans and programs, has now been consolidated and increasingly practiced in the international arena, including developing countries, like Brazil. In this context, this dissertation compares the current status of SEA in Brazil in relation to the situation presented in Mexico, Spain, England and South Africa. A qualitative comparative method, which evaluated each system based on descriptive categories and their criteria was used for the analysis. The categories selected to characterize the SEA systems were formal/legal, administrative/institutional, academic/conceptual and practical/applied. The results have showed that the SEA systems studied present different patterns of development and evolution along time. South Africa, Mexico and Brazil have showed evidence of different practical experiences and also institutional interests, which have motivated the formal reception of this instrument in those countries. However they still present some gaps in relation to formal and institutional structure of SEA, which affect their practical experience. On the other hand, despite some limitations, the SEA systems of Spain and England are more structured and developed, providing empirical evidence of the relevance of institutional and academic spheres to their development. In general, the comparison conducted in this research has showed that there exist different system formats to SEA, depending on the country or context in which it is applied.

The doctoral research revolves around a comparative study of timber modern methods of construction for low-rise, residential buildings in Scotland. The building techniques studied involve both timber-frame panel construction (open-panel and closed-panel systems and structural insulated panels) and massive-timber construction (cross-laminated and nail-laminated timber panels). A non-timber technique is also included in the study: more traditional, load-bearing masonry (blockwork). These different building techniques have been analysed from two complementary aspects: environmental impacts and thermal performance. The environmental study is based on the life-cycle assessment methodology and embraces various aspects: environmental impacts (e.g., climate change, acidification, eutrophication, ozone depletion, etc.), consumption of energy (renewable and non-renewable resources) and production of waste (from non-hazardous to radioactive). The assessment takes a cradle-to-gate approach and, in its structure and method, is informed by the current recommendations of the international standards in the field (i.e., ISO 14040 series). Various environmental trade-offs between construction methods have been identified. In terms of global-warming potential (excluding biogenic carbon sequestration), results suggest that timber-frame buildings show a better performance than masonry buildings; this is particularly true for the open-panel system, which emits about 10% less carbon than the masonry counterpart. Massive-timber buildings tend to cause more carbon emissions than masonry ones. In terms of consumption of non-renewable primary energy, timber buildings do not generally show significant advantages with respect to blockwork-based masonry. In particular, structural-insulated panel systems tend to show very high energy requirements. Timber-based buildings show a tendency to cause increased acidification, eutrophication and creation of low ozone than their masonry counterpart. The level of offsite fabrication that is employed for the erection of the buildings plays an important role in the magnitude of most environmental impacts, which show an average decrease between 5% and 10% when some of the operations are shifted from the construction site to the factory. v The thermal study investigates the performance of the building envelope, and, in particular, of external walls, by means of tests whereby the thermal behaviour of a sample of walls (of full-size section) has been observed and measured over time. On the outside, the walls were exposed to real, natural weather variations throughout the summer. The study especially focuses on the time-dependent response of three different walling systems (which results from their individual cross-sectional arrangements of building components and the associated combination of heat-storage capacity and thermal resistance): a timber-framed wall, a cross-laminated-timber wall and a masonry wall. Thus, the main goal of the study was to characterise the thermal-inertia parameters of these walls. This type of thermal behaviour is related to the repercussions of global climate change at UK level, especially in terms of increase in solar irradiance and temperature, which requires an adaptation of the building-envelope such that it can perform well both during wintertime and summertime, by providing maximum indoor comfort with minimum economic and environmental costs from the construction and operation of buildings. The timber-framed wall possesses the greatest capacity to slow down the propagation of temperature waves from the outer surface to the inner surface (time lag), whereas the masonry wall performs best with respect to reducing the amplitude of temperature oscillation on the inner surface (decrement factor). The cross-laminated-timber wall exhibits intermediate values of both time lag and decrement factor, relative to the other two walls. Both the thermal and life-cycle assessment of the construction alternatives aim at assisting the design and decision-making process in the residential field and at suggesting areas that need to be addressed and improved, towards a coherent evolution of the building techniques included in this study and a step forward in the realisation of sustainable, low-rise dwellings.

Parasites are an important component of every ecosystem, and their interactions with hosts can directly impact the fitness of the host organisms. Despite their significance, it is still largely unknown which host traits predispose a species to increased risk of parasite attack. In the present study, I investigated host and ecological correlates of parasite load in Lake Tanganyikan cichlids using phylogenetic comparative analyses. Specifically, I tested the effect of body size, brain mass, gut length, depth, trophic level, habitat complexity and mating system on parasite prevalence and diversity.  I found that the variation in both average infracommunity richness and parasite prevalence were partly explained by host body mass and habitat complexity. Total parasite diversity, on the other hand, was significantly related to mating behaviour as well as habitat complexity. The comparative analysis presented here is, to the best of my knowledge, the first to investigate determinants of parasite load in Lake Tanganyikan cichlids. As such, my results support several major hypotheses concerning the factors that underlie parasite prevalence and diversity and have broad implications for our understanding of parasite-host interactions.

Le sujet de notre thèse se trouve à la frontière entre le management du Transfert Technologique (T. T. ) et le management interculturel en considérant surtout la version . Le cadre conceptuel est celui de la vision prospective et systémique réalisé une liaison entre les deux approches managériales. La recherche contribue à un avancement dans ce domaine en plusieurs étapes : on a complété la base de données concernant les cinq dimensions de Hofstede (qui comprend 57 pays) avec les données sur la Roumanie après 287 réponses à un questionnaire spécifique. Un panel d'experts a permis d'appliquer la méthode MIC-MAC sur l'ensemble des variables culturelles et celles du T. T. Et de les valider ensuite par la méthode Delphi-Regnier. En utilisant des méthodes de créativité (brainstorming et Philips 66) on a élaboré une méthode basée sur l'analyse structurelle qui permet la prise en compte des quantifications des variables des diverses cultures en vue de hiérarchiser ces variables d'après l'intensité de leur interrelation sur les processus de T. T. La thèse essaie de montrer une possible modalité d'intégration d'une manière pratique des influences culturelles spécifiques à une région dans une stratégie des actions managériales à l'aide d'un outil prospectif adapté (Mic-Mac) aux conditions concrètes. On a testé cette démarche dans le cadre d'une relation d'affaire franco-roumaine

Everyone is talking about the software development methods but these methods are categorised into the different parts and the most important are two categories, one is agile software development methods and second is using the traditional software development methods. Agile software methods are relatively considered to be quick and for the small teams. Our main mission is to check which method is better from each other, so for that purpose we go out in the software development market to meet the professional to ask about their satisfaction on these software development methods. Our research is based on to see the suitable method for the professionals; see the challenges on the adoptability of methods and which method is quicker. To perform this study we have gone through a survey questionnaire, and results are analysed by using mixed method approach. Results shows that professionals from both types of methods are satisfied but professionals with traditional methods are more satisfy with their methods with respect to development of quality software, whereas agile professionals are more satisfied with their methods with respect of better communication with their customers. With agility point of view, our study says that both methods have characteristics which support agility but not fully support, so in such case we need to customize features from both types of methodologies.

The primary objective of this thesis is to estimate the market value of residential unit in Prague. The main valuation method is comparative method. Value estimated on this basis is then compared to the value determined based on the income approach (Direct capitalization method). The differences in the results found in valuation on the basis of selected approaches are presented in the last part of the thesis as well as explanation in what cases it is preferable to use the particular approach. The theoretical part of the thesis contains basic concepts of property valuation. The other theoretical chapters summarize the basic legal legislation in this field and real estate valuation methodology. In the practical part of the work, the valuation of the specific real estate (housing unit in Prague) realized.

Recently, the deep neural network structure caps-net was proposed by Sabouret al. [11]. Capsule networks are designed to learn relative geometry betweenthe features of a layer and the features of the next layer. The Capsule network’smain building blocks are capsules, which are represented by vectors. The ideais that each capsule will represent a feature as well as traits or subfeatures ofthat feature. This allows for smart information routing. Capsules traits are usedto predict the traits of the capsules in the next layer, and information is sent toto next layer capsules on which the predictions agree. This is called routing byagreement.This thesis investigates theoretical support of new and existing routing al-gorithms as well as evaluates their performance on the MNIST [16] and CIFAR-10 [8] datasets. A variation of the dynamic routing algorithm presented in theoriginal paper [11] achieved the highest accuracy and fastest execution time.

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Large scale approaches, namely proteomics and transcriptomics, will play the most important role of the so-called post-genomics. These approaches allow experiments to measure the expression of thousands of genes from a cell in distinct time points. The analysis of this data can allow the the understanding of gene function and gene regulatory networks (Eisen et al., 1998). There has been a great deal of work on the computational analysis of gene expression time series, in which distinct data sets of gene expression, clustering techniques and proximity indices are used. However, the focus of most of these works are on biological results. Cluster validation has been applied in few works, but emphasis was given on the evaluation of the proposed validation methodologies (Azuaje, 2002; Lubovac et al., 2001; Yeung et al., 2001; Zhu & Zhang, 2000). As a result, there are few guidelines obtained by validity studies on which clustering methods or proximity indices are more suitable for the analysis of data from gene expression time series. Thus, this work performs a data driven comparative study of clustering methods and proximity indices used in the analysis of gene expression time series (or time courses). Five clustering methods encountered in the literature of gene expression analysis are compared: agglomerative hierarchical clustering, CLICK, dynamical clustering, k-means and self-organizing maps. In terms of proximity indices, versions of three indices are analysed: Euclidean distance, angular separation and Pearson correlation. In order to evaluate the methods, a k-fold cross-validation procedure adapted to unsupervised methods is applied. The accuracy of the results is assessed by the comparison of the partitions obtained in these experiments with gene annotation, such as protein function and series classification

Four commercially available methods used for the analysis of low-level Chlorine Dioxide (ClO2) concentrations in drinking water were evaluated for accuracy and precision and ranked according to cost, efficiency and ease of the methods under several conditions that might be encountered at water treatment plants. The different analytical methods included: 1.The DPD (N, N-diethyl-p-phenylenediamine) method 2.Lissamine Green B (LGB) wet-chemical method 3.Palintest® kit LGB 4.Amperometric titration All these tests were performed with standard 1.0 mg/L ClO2 either alone or in the presence of different chlorine species, including chlorite ion (ClO2-, 0.5 mg/L), chlorate ion (ClO3-, 0.5 mg/L) and chlorine (Cl2, 1.0 mg/L). The tests were performed with four different matrices, with different concentrations of 0.1 mg/L ClO2, 0.5 mg/L ClO2 and 1.0 mg/L ClO2 at a constant temperature of 20oC and at different temperatures of 0oC, 10oC and 20oC at a fixed ClO2 concentration of 1.0 mg/L. None of the four methods produced the desired level of either accuracy or precision. For all four methods, interference to the measured ClO2 concentration from the addition of ClO2-, ClO3-, and Cl2 was minimal when the methods were performed according to specifications. The Palintest® was the best all-round method because it was easy to perform, performed well at all concentrations tested, and its colored product was stable. The HACH® DPD method was also easy to perform and gave the best results when measuring concentrations of 1.0 mg/L ClO2. The DPD method was less accurate than the Palintest® at lower concentrations. The DPD colored product that formed upon reaction of ClO2 and DPD was unstable, making it necessary to measure the intensity of the colored product at exactly 1 minute. The amperometric titration and lissamine green methods were more cumbersome and time-consuming to perform than either the DPD or Palintest® methods; for this reason they are less desirable for routine use.
Master of Science

We study the development of nonlinear conjugate gradient methods, Fletcher Reeves (FR) and Polak Ribiere (PR). FR extends the linear conjugate gradient method to nonlinear functions by incorporating two changes, for the step length αk a line search is performed and replacing the residual, rk (rk=b-Axk) by the gradient of the nonlinear objective function. The PR method is equivalent to FR method for exact line searches and when the underlying quadratic function is strongly convex. The PR method is basically a variant of FR and primarily differs from it in the choice of the parameter βk. On applying the nonlinear Rosenbrock function to the MATLAB code for the FR and the PR algorithms we observe that the performance of PR method (k=29) is far better than the FR method (k=42). But, we observe that when the MATLAB codes are applied to general nonlinear functions, specifically functions whose minimum is a large negative number not close to zero and the iterates too are large values far off from zero the PR algorithm does not perform well. This problem with the PR method persists even if we run the PR algorithm for more iterations or with an initial guess closer to the actual minimum. To improve the PR algorithm we suggest finding a better weighing parameter βk, using better line search method and/or using specific line search for certain functions and identifying specific restart criteria based on the function to be optimized.

A recent focus in health care policy is on comparative effectiveness of treatments--from drugs to behavioral interventions to medical devices. Medical devices bring a unique set of challenges for comparative effectiveness research. In this dissertation, I develop statistical methods for comparative effectiveness estimation and illustrate the methodology in the context of three different medical devices. In chapter 2, I review approaches for causal inference in the context of observational cohort studies, utilizing a potential outcomes framework demonstrated using data for patients undergoing revascularization surgery with radial versus femoral artery access. Propensity score methods; G-computation; augmented inverse probability of treatment weighting; and targeted maximum likelihood estimation are implemented and their causal and statistical assumptions evaluated. In chapter 3, I undertake a theoretical and simulation-based assessment of differential follow-up information per treatment arm on inference in meta-analysis where applied researchers commonly assume similar follow-up duration across treatment groups. When applied to the implantation of cardiovascular resynchronization therapies to examine comparative survival, only 3 of 8 studies report arm-specific follow-up. I derive the bias of the rate ratio for an individual study using the number of deaths and total patients per arm and show that the bias can be large, even for modest violations of the assumption that follow-up is the same in the two arms. Furthermore, when pooling multiple studies with Bayesian methods for random effects meta-analysis, the direction and magnitude of the bias is unpredictable. In chapter 4, I examine the statistical power for designing a study of devices when it is difficult to blind patients and providers, everyone wants the device, and clustering by hospitals where the devices are implanted needs to be taken into account. In these situations, a stepped wedge design (SWD) cluster randomized design may be used to rigorously assess the roll-out of novel devices. I determine the exact asymptotic theoretical power using Romberg integration over cluster random effects to calculate power in a two-treatment, binary outcome SWD. Over a range of design parameters, the exact method is from 9% to 2.4 times more efficient than designs based on the existing method.

A hipertrofia ventricular esquerda (HVE) é importante fator de risco cardiovascular. O objetivo deste estudo retrospectivo foi verificar a associação de critérios eletrocardiográficos de HVE com as características anatômicas e histológicas do coração, em 51 pacientes submetidos à necropsia. Procedeu-se à medição do diâmetro transverso dos cardiomiócitos e da porcentagem de fibrose do ventrículo esquerdo e direito. Entre os pacientes que apresentavam HVE anatômica, o critério de Romhilt foi positivo em 92,3%, sendo superior aos demais critérios avaliados, com especificidade de 89,5% e sensibilidade de 68,8%, Foi o único que se associou a características anatômicas e histológicas do coração
The left ventricular hypertrophy (LVH) is an important cardiovascular risk factor. The purpose of the present retrospective paper is to examine the association of LVH electrocardiographic criteria with both anatomical and histological characteristics of the heart on 51 patients submitted to the necropsy. The study carried out the measurement of the transverse diameter of cardiomyocytes, as well as the percentage of fibrosis at both left and right ventriculi. Among those patients who presented anatomic LVH, the Romhilt criterium resulted positive in 92.3% of the cases, thus surpassing the other criteria evaluated, with specificity and sensibility up to 89.5% and 68.8% respectively. This was the only criterium associated to both anatomic and histological characteristics of the heart

A ampla diversidade metabólica das cianobactérias é associada não somente a sua importância nos ciclos biogeoquímicos, mas também a sua distribuição global. Tal característica também é responsável pela capacidade destes organismos em produzir uma ampla variedade de substâncias de estruturas incomuns e atividades de interesse para o homem. Microcystis é um gênero cianobacteriano reconhecido como produtor de mais de duas centenas de produtos naturais, incluindo cianotoxinas. Microcystis aeruginosa é uma espécie frequentemente encontrada em florações, portanto causando preocupações sobre sua influência ecológica, especialmente em corpos d\'água doce utilizados para consumo humano. Desta forma, o objetivo deste trabalho foi o levantamento da diversidade e quantidade de metabólitos secundários que podem ser produzidos pela espécie, através de análises genômicas, além de variáveis que podem potencialmente interferir nas análises computacionais, procurando-se por padrões na espécie, e comparando-se 18 linhagens de todos os continentes. Foi encontrado o total de 235 agrupamentos relacionados ao metabolismo secundário, categorizados em 12 classes segundo as estruturas de seus produtos, nas 18 linhagens, evidenciando a riqueza de agrupamentos relacionados ao metabolismo secundário encontrados nesta espécie. Destes agrupamentos, os mais abundantes pertencem às categorias dos Terpenos, Híbridos, Bacteriocinas e NRPS. Entre as NRPS, nenhuma foi comum a todas as linhagens. Ainda, a quantidade de agrupamentos variou entre 6 e 21, e a quantidade de categorias de produtos variou entre 4 e 10, mostrando uma distribuição heterogênea de agrupamentos e tipos de metabólitos preditos. Esta distribuição heterogênea foi detalhada para melhor compreensão deste padrão encontrado na espécie. Dos agrupamentos de NRPS, os três mais frequentes foram selecionados para uma análise pormenorizada de sua estrutura e sequência: aeruginosina (15 linhagens), microcistina (11 linhagens), e micropeptina (15 linhagens). O agrupamento de micropeptina encontrado nas linhagens SPC777, TAIHU98 e PCC 9806 se mostrou amplamente dissimilar com relação à referência utilizada, potencialmente indicando um erro de identificação causado pela plataforma antiSMASH utilizada para a localização dos agrupamentos. Análises de colinearidade genômica mostram uma baixíssima sintenia entre os genomas das linhagens em análise, sugerindo frequentes eventos de reorganização genômica. Ainda, análises de pangenoma mostram um cenário em que mais genomas desta espécie são necessários para a estimativa da quantidade total de genes diferentes que a espécie pode possuir, o que é interessante para futuros estudos de procura de metabólitos secundários. Análises do genoma cerne apontam para uma estimativa segura de 1.944 genes comuns a todos os genomas desta espécie, o que corresponde entre 35% e 50% dos genes em cada linhagem. Análises estatísticas apontam para diferentes graus de interferência não linear da quantidade de sequências contíguas na observação de diferentes padrões de outras características genômicas, sugerindo precaução nas expectativas com relação ao metabolismo secundário em caso de linhagens em que a montagem gênica ultrapasse o limite superior aproximado de 100 sequências contíguas.
The wide metabolic diversity of cyanobacteria is associated not only with their importance in biogeochemical cycles, but also with their global distribution. Such a feature is also responsible for the ability of these organisms to produce a wide variety of substances with unusual structures and activities of interest to man. Microcystis is a cyanobacterial genus recognized as a producer of more than two hundred natural products, including cyanotoxins. Microcystis aeruginosa is a species frequently found in cyanobacterial blooms, thus causing concerns about its ecological influence, especially in freshwater bodies used for human consumption. In this way, the objective of this work was the survey of the diversity and quantity of secondary metabolites that can be produced by the species, through genomic analyzes, besides variables that can potentially interfere in the computational analyzes, searching for patterns in the species, and comparing 18 strains from all the continents. A total of 235 clusters, categorized in 12 classes according to the structure of their products, were found in the 18 strains, evidencing the richness of clusters related to the secondary metabolism found in this species. Of these clusters, the most abundant belong to the categories of Terpenes, Hybrids, Bacteriocins and NRPS. Among NRPS, none were common to all strains. Also, the number of groups ranged from 6 to 21, and the number of product categories ranged from 4 to 10, showing a heterogeneous distribution of predicted groupings and types of metabolites. Such a heterogeneous distribution was detailed for a better understanding of this pattern found in the species. Of the NRPS clusters, the three most frequent were selected for a detailed analysis of their structure and sequence: aeruginosin (15 strains), microcystin (11 strains), and micropeptin (15 strains). The micropeptide cluster found in the SPC777, TAIHU98 and PCC 9806 strains was widely dissimilar to the reference, só potentially indicating an identification error caused by the antiSMASH platform used to locate the clusters. Genomic collinearity analyzes showed a very low synteny among the genomes of the strains under analysis, suggesting frequent events of genomic reorganization. Also, pangenome analyzes show a scenario in which more genomes of this species are needed for the estimation of the total amount of different genes the species may possess, which is interesting for future studies conserning secondary metabolites. Coregenome analyzes point to a reliable estimate of 1,944 genes common to all genomes of this species, which corresponds to 30% up to 50% of the genes in each strain. Statistical analyzes point to different degrees of non-linear interference of the number of contiguous sequences on the observation of different patterns of other genomic characteristics, suggesting necessary caution about expectations regarding the secondary metabolism in case of strains in which the gene assembly exceeds the approximate upper limit of 100 contiguous sequences.

Le travail presente dans ce memoire traite de l'utilisation des methodes de reconnaissance des formes floue en vue de leur application au diagnostic. Les principes, le codage algorithmique, l'analyse des performances de plusieurs methodes de reconnaissance des formes floue et l'introduction des methodes de rejets sont presentes. Une premiere partie, constituee des deux premiers chapitres, presente une synthese des principales procedures de diagnostic, des techniques de reconnaissance des formes, et des methodes d'analyse de donnees, en s'interessant plus particulierement aux techniques decisionnelles pour la recherche d'appartenance. Une seconde partie, constituee des chapitre 3 et 4, presente la notion de reconnaissance des formes floue, ainsi que differentes methodes de determination d'appartenance. Il s'agit plus particulierement de l'etude de trois methodes supervisees : tout d'abord la methode des regles floues distribuees, puis celle du fuzzy pattern matching , et enfin la methode des k-plus proches voisins flous. Pour chacune de ces methodes, apres avoir enonce les proprietes caracteristiques, nous proposons des ameliorations. Le dernier chapitre fait une estimation comparative des differentes methodes proposees. La comparaison porte essentiellement sur les taux d'erreur de classement, l'influence du volume de donnees sur celui ci, et du temps de calcul.

O presente trabalho tem por objetivo implantar um método para calibração de sistema de medição linear por interferometria laser por meio de comparação a um outro sistema laser de referência. O referido método é considerado mais simples que a calibração por componentes realizada atualmente e, conforme demonstrado no trabalho, apresenta confiabilidade metrológica que atende a exatidão necessária para as aplicações dos laseres em metrologia dimensional, vindo suprir uma necessidade metrológica dos laboratórios credenciados pelo Instituto Nacional de Metrologia, Normalização e Qualidade Industrial (Inmetro) e do parque industrial brasileiro, usuários destes sistemas de medição. A implantação do sistema para calibração de lasers de medição foi baseada em normas internacionais de calibração e de cálculo da incerteza de medição e utilizou um sistema laser de referência calibrado no Inmetro, com rastreabilidade a padrões nacionais, com as menores incertezas possíveis. O método de medição implantado realiza a calibração de um sistema laser por comparação a outro utilizando medições feitas a partir do deslocamento da mesa onde é a apoiado o prisma óptico. O que é de fato analisado é a diferença das medições dos dois sistemas laser para um mesmo deslocamento. Foram registradas as diferenças das indicações de 200 mm em 200 mm de deslocamento, em um total de 2000 mm, que variaram de 0,027 µm a 0,690 µm. Foram realizadas três medições para cada deslocamento e quatro repetições completas do procedimento em dias diferentes, com variação do desvio padrão de 0,009 µm a 0,098 µm e incertezas expandidas que variaram de 0,109 µm a 0,306 µm. São apresentadas a metodologia de calibração, cálculos das correções, fontes de erros e cálculos da incerteza de medição para a comparação de sistemas laseres de medição linear.
The present work aims at the implementation of a calibration method for interferometric linear laser measurement systems by comparison to another reference system. The proposed method is considered simpler than the calibration by components that is carried out today at Inmetro (National Institute of Metrology, Standardization and Industrial Quality) and, as demonstrated along this work, presents the metrological reliability and accuracy necessary for several applications of lasers in dimensional metrology. This approach will supply the metrological needs of several laboratories accredited by Inmetro and of the Brazilian industry in general, users of such measurement systems, regarding cost and time of calibration. The method implemented was based on international technical standards related to calibration and uncertainty calculation and used a reference system calibrated at Inmetro, with traceability to national standards, with the lowest uncertainties that could be achieved. The said method performs the calibration of a laser system by comparison to another through measurements of the displacement of the table where the optical prism rests. What is indeed analyzed is the difference of the measurements obtained by the two laser systems for the same table displacement. The differences were recorded for each displacement of 200 mm, in a total of 2,000 mm, their variation being from 0.027 µm to 0.690 µm. The whole procedure was repeated four times, in different days, with three measurements for each displacement. Their standard deviation varied from 0.009 µm to 0.098 µm while their expanded uncertainties varied from 0.109 µm to 0.306 µm depending on the value of the displacement. The calibration methodology, correction calculation, errors sources and measurement uncertainty calculations for the linear measurement laser systems comparison are presented in this dissertation.

La politique de développement territorial constitue une partie de la politique du développement. L'accent est mis sur la dimension territoriale. On utilise l'analyse comparative comme méthode applicative et de recherche. La spécificité de la dimension territoriale peut être perçue par quatre caractéristiques de l'espace : sa continuité, sa territorialité, son déterminisme et son contenu. L'analyse comparative peut être effectuée selon plusieurs critères. Dans cette thèse elle est présentée selon quatre critères : temps, niveaux territoriaux (local, régional, national, continental et mondial), spécificités culturelles et enfin politiques sectorielles de développement. Basées sur l'analyse de six études comparatives existantes, deux études de cas principales sont présentées, celle de la France et celle de la Serbie, avec leurs niveaux subnationaux et nationaux, ainsi qu'un aperçu de dix autres pays importants, selon trois critères principaux: la surface, la population et la densité de population. La justification d'une nouvelle discipline au sein de l'aménagement du territoire est développée dans la dernière partie ; cette discipline qui peut être appelée aménagement comparatif utilise l'analyse comparative comme méthode pour la recherche et la réalisation des politiques du développement territorial.

This study was initiated by the authors in order to evaluate the Twister™ method’s environmental pros and cons in relation to other traditional floor care methods using polish and wax. This has been ascertained through a Life Cycle Assessment which was conducted within the study. The study has been in co-operation with HTC Sweden AB, the developer of the Twister™ method. The results show that the elements of the Twister™ method with the greatest environmental impact are the scrubbing machine that is used and the low energy consumption that the Twister™ method requires. The results also show that the Twister™ method has a significantly lower environmental impact than floor care methods using polish or wax. The parts of the Twister™ pad that have the greatest environmental impact are the industrial diamonds and the material that makes up the pad.

Abstract The following thesis discusses the problems of apprising methods of real estate with regard to subjective factor which is inherited in the process by the appricing subject. It discusses methods, evaluations and points out possible disturbing effects and faults which could influence these methods. The example case study shows possibilities in using the power of fuzzy logic, which contributes in a significant way to higher transparency, reproducibility and portability of the whole appricing process. The main goal of the thesis is to introduce the advantages and power of a new evaluation method in the appricing process.

Orientador: Milton Mori
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: O objetivo deste trabalho foi o estudo comparativo de duas modelagens para representação de um escoamento gás-sólido. Na primeira modelagem avaliou-se uma correlação de arraste apresentada recentemente na literatura, baseada em simulações lattice Boltzmann, aplicada a escoamentos gás-sólido. Na segunda observou-se o efeito da variação do coeficiente de especularidade na condição de contorno na parede sobre os perfis de velocidade da fase particulada. Grande atenção tem sido dada a modelagem matemática de escoamentos multifásicos, em especial ao gás-sólido, uma vez que vários processos industriais utilizam-se desta operação. Porém o desenvolvimento de modelos analíticos que incluam todos os fenômenos de transferência de massa, energia e quantidade de movimento não encontra-se disponível, devido principalmente a grande complexidade dos fenômenos envolvidos. Neste aspecto a fluidodinâmica computacional (CFD) tem demonstrado ser uma boa alternativa para o estudo de sistemas complexos, sendo diversos estudos, não somente de engenharia, aplicando esta técnica, publicados todos os anos. Como forma de validar os resultados obtidos por este método numérico, escolheu-se um caso de estudo em escala de laboratório. Os softwares comerciais ANSYS CFX 10 e FLUENT 6.3 foram utilizados para a definição e resolução do problema, além do pós-processamento. Os resultados obtidos foram comparados com os dados numéricos de um trabalho de mestrado do PQGe, bem como com dados experimentais da literatura. Pode-se perceber que os resultados, para a primeira abordagem não apresentaram melhoras em relação a outras modelagens das forças entre e intra-partículas, além do maior tempo computacional requerido. A segunda abordagem demonstrou valores adequados para o coeficiente estudado
Abstract: The aim of this work was a comparative study of two different modeling to represent a gas-solid flow. The first approach consists of a new drag correlation presented in the literature. This relation was obtained through lattice Boltzmann simulations of gas-solid flow, thus not depending on empirical data. The second looked for the effects of the variation of the specularity coefficient at the wall boundary condition. Multiphase flow modeling is gathering great attention, especially to gas-solid flows, due to its importance in industrial processes. However analytical models that take into account the mass, momentum and energy transfers are not available, mainly because of the complexities evolved in such systems. Therefore Computational Fluid Dynamics (CFD) has proved to be a viable alternative, having a large number of scientific works been published in recent years. In order to validate the results a comparison with other simulations using different modeling, done by another member of the PQGe laboratory, and with experimental data was carried out. The commercial softwares ANSYS CFX 10 and FLUENT 6.3 were used to define and numerically solve the problem, also to post process the results. For the first approach, the comparison showed that the studied drag correlation gave no improvement upon the other two models analyzed. Also a longer computational time was required, which can not be ignored as an important parameter in CFD simulations. As for the second approach, it was possible to obtain adequate values for the specularity coefficient
Mestrado
Desenvolvimento de Processos Químicos
Mestre em Engenharia Química

Thesis (Ph. D.)--Ohio State University, 2004.
Title from first page of PDF file. Document formatted into pages; contains xvii, 342 p.; also includes graphics. Includes bibliographical references (p. 164-171). Available online via OhioLINK's ETD Center

The adaptive serrated nozzle (ASN) is one of the most promising concepts to help reduce the noise level generated by aero-engines. Shear between a hot air stream and ambient air at the nozzle exit creates noise. The serrated nozzle is designed to protrude into the air stream causing mixing between the two air streams reducing the noise level. Adaptive control system using shape memory alloy (SMA) actuators deploy the protrusion only when required in order to maximise fuel efficiency. The successful joining of NiTi shape memory alloy (SMA) to the titanium parent structure is critical to the development of the adaptive serrated nozzle. However, joining of SMAs to dissimilar metals is widely known as extremely difficult if not impossible. This research provides a preliminary study into the potential of using SMAs in large engineering applications such as the ASN and the development of viable joining methods for joining SMA to titanium based alloy. Five most favourable conventional joining methods were selected for experimental investigation. Results proved that the successful joining of SMA to dissimilar alloys was extremely difficult, joint failures were mainly due to the formation of brittle intermetallics at joint interfaces. The formation of these intermetallics occurs irrespective of the type of joining method and level of heat input employed. However, it has been shown that the formation of these intermetallics can be suppressed by the manipulation of the joint composition. A marked improvement in joint performance has been achieved for joints that contained no more than 25 at% nickel. Joint improvement has also been achieved through the addition of titanium at the joint, although further research is necessary to investigate the effect of titanium addition to joint performance.