Journal articles on the topic 'Comparative public notice'

AbstractPublic participation in administrative rulemaking is typically embodied in notice-and-comment procedures essentially mandating the publication of a proposed rule and an opportunity for the public to submit comments thereon prior to its adoption. This article presents a comparative analysis of the notice-and-comment regimes under the Philippine Administrative Code (PAC) and the United States’ Administrative Procedure Act (APA). In stark contrast to the Philippine legal framework which renders compliance with the notice-and-comment procedure practically discretionary on the part of the agency, the APA prescribes the conduct of notice-and-comment as a general rule, and courts rigorously police agencies’ compliance with the procedure. This article argues that the mandatory (or discretionary) nature of the notice-and-comment mechanism impinges on the efficacy of procedural challenges to administrative rules, the standard of judicial review applied to agency statutory interpretation, and the statutory creation of public norms. The article hopes to inspire a re-evaluation of the Philippine framework while providing valuable lessons to other jurisdictions with similar legal architectures.

This entry outlines the UN jurisprudence of the Human Rights Committee (HRC) on public peaceful assemblies. It compares the protection of the right (freedom of assembly) in the UN system with the protection provided on a supranational/regional level and the domestic (constitutional) level, relying on the landmark cases on each of the discussed themes. The entry aims at exploring the underlying values, scope, and limitations of the right to freedom of assembly in the UN system and the comparative jurisprudence. The underlying values of the right to freedom of assembly explain the rationale for the legal protection of the right. Moreover, the entry examines the scope of the right of freedom of assembly, in order to draw the boundaries of the right and define its content. The analysis of the limitations focuses on the advance notice requirement and permit system, limitations on the time, place or manner of the assembly, and restrictions associated with heckler’s veto or having a hostile crowd. The discussion on limitation assesses whether there are historical, societal, and demographic factors that can restrict the exercise of the right to freedom of assembly, or if different regions/States are equally subjected to the same normative principles. Finally, the entry sketches the challenges and normative reflections, regarding the right to freedom of assembly, in light of the Covid-19 pandemic in 2020.

In this paper the challenges imposed on corporate governance of water services in Italy and Sweden are analyzed and compared. From the comparative analysis we notice that with externalization of services ore stakeholders become involved in the provision of the services. These stakeholders have common as well as divergent interests and the challenges thus become to find an alignment of interest among stakeholders in order to secure a sustainable provision of the services. The comparative analysis indicates that such lignment is especially difficult when stakeholders have heterogenous background (public and private sector).

The Nigerian Public Officers Protection Act, (POPA) is part of statute of general application and is deeply rooted in the Public Authorities Protection Act of 1893 which has been repealed in England. The original intendment of POPA is to offer special protection to public officers in the performance of their public duties by entrenching a three-month limitation period for action against public officers in the performance of their duties. However, the emerging jurisprudence has interpreted the definition of person to include artificial persons, thereby bringing in more public entities under the protection. In addition, many public authorities enjoy further protection by reason of entitlement to pre action notice as entrenched in their enabling Acts. The effects of the dual protection are the seeming discriminatory and unequal treatment of private corporations and individual vis a vis public authorities. Hence, the widely held view that the dual protection is anachronistic and a clog in the wheel of justice as many litigants have been left without remedy on procedural grounds of non-issuance of pre action notice or failure to institute an action within the three-month limitation period. This paper makes enquiries on whether the dual protection being enjoyed by public officers and institutions constitute impediments to access the court of law and justice. The paper adopts a comparative analysis to investigate the contemporary approaches of a number of countries that have repealed or revised the dual protection offered public authorities. Lessons learned from other jurisdictions formed the basis of final recommendations of the paper which primarily calls for an urgent review of POPA.

Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors are currently being evaluated in clinical trials. This is a clear indication that protein kinases still represent major drug targets for the pharmaceutical industry. In a previous work, we have introduced PKIDB, a publicly available database, gathering PKIs that have already been approved (Phase 4), as well as those currently in clinical trials (Phases 0 to 3). This database is updated frequently, and an analysis of the new data is presented here. In addition, we compared the set of PKIs present in PKIDB with the PKIs in early preclinical studies found in ChEMBL, the largest publicly available chemical database. For each dataset, the distribution of physicochemical descriptors related to drug-likeness is presented. From these results, updated guidelines to prioritize compounds for targeting protein kinases are proposed. The results of a principal component analysis (PCA) show that the PKIDB dataset is fully encompassed within all PKIs found in the public database. This observation is reinforced by a principal moments of inertia (PMI) analysis of all molecules. Interestingly, we notice that PKIs in clinical trials tend to explore new 3D chemical space. While a great majority of PKIs is located on the area of “flatland”, we find few compounds exploring the 3D structural space. Finally, a scaffold diversity analysis of the two datasets, based on frequency counts was performed. The results give insight into the chemical space of PKIs, and can guide researchers to reach out new unexplored areas. PKIDB is freely accessible from the following website: http://www.icoa.fr/pkidb.

Abstract Objective Healthcare accreditation surveyors are well positioned to gain access to hospitals and apply their existing data collection skills to research. Consequently, we contracted and trained a surveyor cohort to collect research data for the Deepening our Understanding of Quality in Australia (DUQuA) project. The aim of this study is to explore and compare surveyors’ perceptions and experiences in collecting quality and safety data for accreditation and for health services research. Design A qualitative, comparative study. Setting and Participants Ten surveyors participated in semi-structured interviews, which were audio recorded, transcribed and coded using Nvivo11. Interview transcripts of participants were analysed thematically and separately, providing an opportunity for comparison and for identifying common themes and subthemes. Intervention(s) None. Main Outcome Measure(s) Topics addressed data collection for healthcare accreditation and research, including preparation and training, structure, organization, attitudes and behaviours of staff and perceptions of their role. Results Five themes and ten subthemes emerged from the interviews: (1) overlapping facilitators for accreditation and research data collection, (2) accreditation-specific facilitators, (3) overlapping barriers for accreditation and research data collection, (4) research data collection-specific barriers and (5) needs and recommendations. Subthemes were (1.1) preparation and training availability, (1.2) prior knowledge and experiences; (2.1) ease of access, (2.2) high staff engagement, (3.1) time, (4.1) poor access and structure, (4.2) lack of staff engagement, (4.3) organizational changes; (5.1) short-notice accreditation and (5.2) preparation for future research. Conclusions Although hospital accreditation and research activities require different approaches to data collection, we found that suitably trained accreditation surveyors were able to perform both activities effectively. The barriers surveyors encountered when collecting data for research provide insight into the challenges that may be faced when visiting hospitals for short-notice accreditation.

Countries of former Yugoslavia and Albania are considered as countries with many common problems as well as changes, which in this context are regarded as insignificant. On their way towards development, these countries are characterized by common problem, among which the most sensitive have been and still remain, unemployment, increasingly compressed public administration, unjustified optimism when planning the budget, mismanagement of public finances and poor fiscal discipline which mostly depends on being or not an election year. In these countries we notice the lack of harmony between economic and fiscal policies and the real needs of the economy. This is seen as other major common ofWest Balkan countries. This similiarity of problems narrows the possibility of competition associated to the foreign investment absorbing capacity. But, which is the moacroeconomic picture in the countries of West Balkan? What are their tax systems? How much are the foreign direct investments? Does the tax system serve as a promoter for these invvestments? This paper represents a comparative analysis of the fiscal systems in the countries of this region. The subject of this paper is the protection with arguments of the economic and fiscal policy which are built for the economic development of a country. This because we are given that there are two types of experiences related to tax system, one of which handles taxes as instruments for revenue collection and the other as a promoter factor for economic development.

Social phobia is an anxiety disorder characterized by heightened fear and avoidance of one or more social or performance situations, including public speaking, meeting new people, eating or writing in front of others, and attending social gatherings. People with social phobia are typically anxious about the possibility that others will evaluate them negatively and/or notice symptoms of their anxiety. Social phobia affects up to 13% of individuals at some time in their lives and is usually associated with at least moderate functional impairment. Research on the nature and treatment of social phobia has increased dramatically over the past decade. As with many of the anxiety disorders, sensitive assessment instruments and effective treatments now exist for people suffering from heightened social anxiety. Typical assessment strategies include clinical interviews, behavioural assessments, monitoring diaries, and self-report questionnaires. Treatments with demonstrated efficacy for social phobia include pharmacotherapy (for example, phenelzine, moclobemide, selective serotonin reuptake inhibitor [SSRI] medications) and cognitive behaviour therapy (CBT) (for example, cognitive restructuring, in vivo exposure, social skills training). Although preliminary comparative studies suggest that both approaches are about equally effective in the short term, each approach has advantages and disadvantages over the other. Trials examining combined psychological and pharmacological treatments are now under way, although no published data on the relative efficacy of combined treatments are currently available.

Introduction. During the COVID-19 pandemic variety of digital tools and technologies were demonstrated owing to the global digitalization of education and the total transition to online learning. The purpose of present research is to determine factors of digitalization of education and their effect on transformation of social values among high school students in conditions of the COVID-19. The results of research on social values of students were considered using comparative analysis. It was revealed that the paradigm of values among young people changed from an individual-personal one at the beginning of the XXI century to the social oriented paradigm – tolerance, openness, public recognition through social networks, self-development and contribution to the community. Materials and Methods. The analysis of pedagogical experience in the field of digitalization of education allowed to formulate the main factors of global digitalization of education and to highlight positive and negative aspects of online learning. According to M. Rokich’s method, an empirical study of instrumental values transformations was carried out among 137 students of Ural Federal University in the conditions of full-time online learning. A questionnaire method was implemented to determine studentsʼ attitude to online learning during COVID-19 pandemic and possibility for further development of this form of learning. Results. It was revealed that only 13.7% of respondents did not notice any decrease in the quality of learning and did not experience discomfort in obtaining knowledge in online form. According to the studentsʼ opinion the values that are subjected to transformation are the following: efficiency, self-control, responsibility, honesty. It can be concluded that the era of network personality and new scientific knowledge in pedagogy has begun. Online learning is a fait accompli which requires scientific substantiation of a new didactics and social values system development among students in a digital education environment. Discussion and Conclusion. Achieved results contribute to ecological system of new digital services that change life and educational activities of a human, as well as transform his personality and values system. Thus, for the purpose of health and emotional intelligence preservation in students the continuation of interdisciplinary study of various aspects of education digitalization is required.

Abstract. Work exploring the relationship between public opinion and public policy over time has largely been restricted to the US. However, a wider application of this line of research can provide valuable insights into whether and how representation varies across political systems. This paper takes a step in this direction using a new body of data on public opinion and government spending in Canada. Analyses reveal that the Canadian public notices and responds (thermostatically) to changes in public spending in particular domains, and also that Canadian policymakers represent these public preferences in spending. The extent and nature of public responsiveness and policy representation varies across domains. Relationships are more pronounced in certain domains, and they are more ‘specific’ in some domains and more ‘global’ in others. The findings generally accord with the results of similar work in the US and the UK, although the details differ in important ways. Indeed, the differences are strongly suggestive about the structuring role of institutions.Résumé. Les travaux portant sur la relation entre l'opinion publique et les politiques publiques se sont longtemps limités surtout aux États-Unis. Cependant, l'élargissement de cette piste de recherche peut fournir de précieuses connaissances sur les variations de la représentation au sein des systèmes politiques. Cette étude s'oriente dans cette direction en utilisant un nouveau corpus de données sur l'opinion publique et les dépenses du gouvernement au Canada. Les analyses révèlent que, dans certains domaines, la population canadienne observe les changements liés aux dépenses publiques et y réagit (de façon thermostatique) et que les décisionnaires canadiens traduisent les préférences de la population dans les dépenses. La portée et la nature de la réceptivité de la population ainsi que la représentation des politiques varient d'un domaine à l'autre. Les connexions sont plus étroites dans certains domaines, plus “ spécifiques ” dans d'autres et enfin, plus “ globales ” dans d'autres encore. En général, les résultats sont en accord avec ceux des travaux similaires menés aux États-Unis et au Royaume-Uni, malgré des différences importantes sur certains points de détail. En fait, les différences sont très évocatrices du rôle structurant des institutions.

The financial system of the advanced countries develops according to two basic models – a bank-based system and a market-based system, depending on the level of protection of the rights of owners, investors and lenders. A paradigm shift in functioning of global financial system and financial systems of all countries is based on financial law, which formalizes all financial relations. Reviewing the financial system of Ukraine, the researchers pay a special attention to public finance due to its substantial share in redistribution of Ukraine’s GDP. A comparative analysis of the concept “financial system” makes it possible to draw a certain analogy with the approaches of experts in financial law. From the economic point of view, a country’s financial system includes three key areas – state finance, household finance and corporate finance, which are closely interrelated. Matching these three spheres with the legal approach, state finance is defined as public finance, while household finance and corporate finance are referred as private finance. The financial market functions as a part of the financial system. In economic terms, the financial system is a dynamic and open environment, while it implies an intense movement of financial resources, a rapid emergence of new financial instruments and integration into the global financial market. From the legal point of view, the financial system is a static financial and legal phenomenon, which includes centralized and decentralized public funds, as well as funds of business entities and individuals.

Recently, negative trends towards the environment where the system of Mass Passenger Public Transport (MPPT) operates continue to grow. Mobility and citizens’ standard of living are constantly increasing. A significant increase in using private cars (level of motorization) along with all negative consequences faced under such circumstances as an increase in traffic volume, congestions, a decrease in travelling speed, a higher number of traffic accidents, greater negative influence on the environment etc. can be noticed. The city of Belgrade has recognized the significance of continuous research and has monitored the quality of Mass Passenger Public Transport service as well as changes that are taking place in order to influence some specific parts of transport and traffic policy in the city. This paper contains the benchmarking of results obtained in research and a trend towards changes in the expected and perceived quality of service (QoS) within the system of Mass Passenger Public Transport in Belgrade within the period from 2005 to 2007.

The concept of mutual funds in India dates back to the year 1963. The era between 1963 and 1987 marked the existence of only one mutual fund Company in India, namely the Unit Trust of India (UTI), with Rs. 67 billion assets under management (AUM). Few other mutual fund companies entered the mutual fund market later on. The private sector funds started penetrating the fund families during 1993. Kothari Pioneer was the first private sector mutual fund company in India which has now merged with Franklin Templeton. By the end of 1993, the total AUM of the industry was Rs. 470. 04 billion. Just after ten years with private sector penetration, the total assets rose up to Rs. 1218. 05 billion and till 2004, it reached the height of 1540 billion. The total AUM of the mutual fund industry has risen up to 14000 billion in April, 2016. Today there are 43 mutual funds in India offering a number of schemes suited to the needs of different type of customers. It has been noticed that the private sector mutual funds have been taking more risks and have also been able to gain higher returns on an average. This paper tries to highlight the comparative performance of public and private sector mutual funds and also throw light on the scope of the existing potential of the fund market in the face of traditional risk aversion of the investors and huge rise in financial assets.

In the article was carried out a comparative analysis between two distinctive psychology schools: the cultural-historical psychology of L.V. Vygotsky and the positive psychological school. Distinct are a number of significant similarities between their basic ideas that are valuable both for the development of human knowledge and for public practice. The authors have outlined and systematized the leading personal and intellectual qualities of the famous psychologists who have created the most promising theories in the psychological science. The category is highlighted as well as a small group of visionary psychologists who have identified the most important problems of man and psychology and have offered the best quality solutions to these problems. These are W. James, S. Freud, L. Vygotsky, E. Eriksson and A. Maslow; We’ve noticed that Vygotsky alone meets all the criteria, as if the concept of insightful psychologists was modeled over his creative work and his personality.

Purpose: To explore and to analyze the global experience in anticorruption compliance management and to highlight exceptional importance of the anticorruption compliance system to be implemented in Ukraine for fighting corruption; to determine necessary steps to involve workers to the local anticorruption program; to offer specific recommendations for reforming the existing anticorruption compliance system in Ukraine. Methodology: The study was conducted with general scientific (formalization, abstraction, analysis, and synthesis) and specific scientific (formal and legal, comparative and legal, and legal forecasting) cognitive methods applied. Result: Upon thorough investigation of the issue, the author concluded that the anticorruption compliance system should be approved upon discussion with public officials, offered a new form of this discussion to be effective and to function in fighting against corruption offenses in domestic practice, and noticed that compliance management should involve professional standards, powers distribution regulation, and ethics rules determination. Applications: The study is known to be innovative in Ukraine and the results might be interesting and useful for domestic legislators and public administration subjects at the building of the highly effective anticorruption compliance system. Novelty/Originality: The study is believed to cast some light on the gaps in this issue which needed to be clarified since previous poor efforts seem still contradictory. The subject of the study is considered in Ukraine for the first time. The results of the study are obtained based on the independent investigation of the current anticorruption program in the public service and might be promising for effective application.

The technology is getting advanced and likewise the social media is gaining maximum attraction of individuals. The trends of the world are changing day by day so that the impacts are also changing as per needs and demands of the world. Social media has made the changes in the process of interaction between the public and government officials. Middle East communities have great access to new technologies and internet, especially, the Gulf Cooperation Council countries (GCC) that are recognized by advanced infrastructures. Therefore, a sharp increase in social media use is noticed in the area particularly the youth who are more attracted to these platforms. This paper focus on Uses and gratifications of social media use among college students in United Arab Emirates and Kuwait for three social media sites: Twitter, Instagram, and Snapchat. Mixed methodologies are applied (quantitative and qualitative) to explore various use and gratifications factors as well as other social factors among youth that contributes in the adoption of these social network sits (SNSs). Moreover, several statistical tests were performed to analyze the collected data. Few research articles have been published about new and social media platforms use in the region; however, comparative studies were rarely noticed regarding this subject. The survey includes (N=190) samples between Kuwaiti and Emirati students. The study reveals that entertainment is the major use and gratification reason for using the three platforms, while the main social factor is identification. Social media is vital when it comes to the issue of the national, political, and business life.

Research background: In the era of demographic changes and the need for rationalization of public expenditure, the European Union social policy promotes the activation approach. In addition, a growing importance of increasing the effectiveness and efficiency of public entities can be noticed. These phenomena are visible in the implementation of the labour market policy. However, the EU countries represent a different approach to spending public funds on issues related to the implementation of labour market policy. Purpose of the article: The authors are presenting the main theoretical assumptions concerning effectiveness and efficiency of labour market policy. Moreover, in the paper the EU countries are classified in clusters according to their level of expenditure on different categories of LMP. A comparison of the situation over ten years — in 2004 and 2014 — has also been conducted. In 2004, ten new members entered the EU, and the year 2014 presents the most current data in the analyzed area. Methods: As a research method cluster analysis was applied. Cross-country labour market situation throughout the EU is presented by the analysis of the Eurostat data. The countries are grouped in clusters following Ward's and k-means methods. Findings & Value added: There is a need to work out a complex evaluation of labour market policies in the EU to provide comparative analysis of the EU countries (or groups of countries). It would allow to determine the level of development of the country in terms of the efficiency of labour market policies. The EU countries with the best labour market indicators represent diverse levels of LMP expenditure.

Introduction: The objective of this study was to compare the magnitude of birth weight and proportion of low birth weight in a hospital over a decade. Materials and Methods: A descriptive study was undertaken in a public funded hospital catering to rural and urban population of northern India. Pertinent information was collected for all intramural singleton births using structured proforma for a sample period in a calendar year. For comparison purpose birth data was extracted from log books for the corresponding period of previous decade also. Data management was done using MS excel sheet and analysis carried out by computing descriptive statistics using software statistical package. Results: The mean (2568 + 596.7 gm) & median (2600 gm) birthweight recorded for 2011 was low in-comparison to 2657 + 581.7gm (2750 gm) for 2001. The prevalence of low birth weight (LBW) was 36.1% (2011) in comparison to 30.5% (2001) and the state of deterioration was found to be statistically significant (p<0.001). Higher proportion of LBW birth was observed amongst un-booked ANC, pre-term, anemic mothers and whose residence was from outside the district of location of study institute (<0.001). Statistically significant (<0.001) and higher perinatal mortality was noticed in LBW neonates. Rising level of maternal education was protective against LBW. Mothers with their first pregnancy gave higher proportion of LBW births in comparison to mothers with higher gravida status (<0.001). DOI: http://dx.doi.org/10.3126/jnps.v33i1.6176 J Nepal Paediatr Soc. 2013;33(1):15-20.

This paper aims to analyze the possibilities and limitations of using synthetic indicators using two globally applied systems as a reference, the Municipal Human Development Index (MHDI) and the City Prosperity Index-CPI. Therefore, aims to analyze two different urban realities: São Paulo (SP) and Fortaleza (CE), based on two indexes: The Municipal Human Development Index (MHDI) of the United Nations Program (PNUD) and the City Prosperity Index (CPI) started in 2012 by the United Nations Program for Human Settlements (ONU-Habitat). The MHDI is based on indicators in three dimensions: longevity, education, and family income, while the CPI measures the characteristics of the municipalities in terms of productivity, infrastructure, inclusion and social equity, quality of life, environmental sustainability, and governance and legislation. Comparative analysis of the results of indicators that reveal the limitations and potentials considered for the construction of improved systems indicators. It is noticed, from the analyzed properties, factors that go beyond the character of the indicator must be considered. Efficiency in the collection, acceptance of the target audience, and qualitative analysis must be considered in use for the adequate measurement of the actions developed in the municipal public management and for the understanding of the appropriate and social changes in the cities.

This paper focuses on determining the current state of adoption of new information and communication technologies by the population of EU countries from the Central and Eastern parts of Europe (referred in the paper as CEE-EU countries). We have conducted a detailed analysis between Romania and Bulgaria because there are historical, geographical, political and economic similarities between these two neighbouring countries. In order to objectively reflect the results of the comparative analysis at the regional level, we have used the data provided by the World Economic Forum through the Competitiveness Index, the International Institute for Management Development through the Competitiveness Yearbook and the International Telecommunication Union through the ICT Development Index. The results of the comparative analysis reflect many regional disparities. At the same time, it can be noticed that both Romania and Bulgaria are the countries with the weakest results regarding the penetration rate of Internet accessibility in their populations, a fact which leads to a low degree of adaptability of the human capital to new information technologies and, implicitly, a low rate of adoption of the Internet in the sphere of business and public services. This is explained by the insufficient development of ICT infrastructure in the rural area, caused by numerous factors such as insufficient economic development and the low purchasing power of the population, but also by the relatively low level of education in ICT use. Although the influx of information and communication technologies occurred after the 1990s, namely at a time when even countries like Romania or Bulgaria were already part of the free market economy, the gaps recorded during the communist regime (economic, but especially socio-cultural), were apparently difficult to recover in the years to come, therefore this upsurge in information technology has been somewhat delayed in the South-Eastern area of Europe.

In the last decades, an increased interest has been expressed by researchers from worldwide towards studies about economic valuation of protected areas given that environmental public goods are not always traded on a market. Economists have struggled with this subject for decades and have developed several methods to estimate the economic values of these goods, known as non-market valuation methods. This paper reviews and presents a brief analysis of the most popular techniques as applied to natural areas, which are compared after grouping the research steps in five common steps for a consistent comparative analysis. Moreover, renowned studies conducted worldwide are revealed for each of the methods. A special interest has been noticed towards the estimation of welfare measures, such as Willingness To Pay (WTP) and consumer surplus, and towards differentiating user groups, as well as introducing several factors that may influence the decision to visit the natural areas. The case of Romanian national and natural parks is discussed in detail with the purpose to emphasize the need to continue the research in the field. The unique character of each of the studied parks, marked by geographic and cultural aspects, was confirmed through statistic analyses and thus welfare measures were determined for each park separately. The performed analyses proved that the methods have applicability in Romania as well.

Purpose The purpose of this paper is to investigate the extent of corporate disclosure on human resources (HR) in the annual reports of top-performing Indian companies. Design/methodology/approach The paper explores the extent to which top 82 companies from India present information about HR in their annual reports. This paper examines the annual reports of each of the top Indian firms listed on the Bombay Stock Exchange, using the “content analysis” method. Statistical tests have been performed to analyze the difference between the HR disclosure score across public and private sectors and disclosure variations among various industrial sectors. Findings In-house training programmers has been noticed to be the favorite item of disclosure followed by safety awards/certifications and statements regarding cordial relations with the employees/unions. A majority of the Indian firms have ignored significant HR issues such as employee welfare fund, maternity/paternity leaves, holiday benefits, employee loans, adopting old age homes, etc. Overall, the paper reflects low HR-related disclosures. Originality/value This is the first paper on the disclosure of HR by the Indian corporate sector in the CSR domain with a disclosure analysis for a period of nine years. This paper provides new directions for the literature in this area and may promote comparative studies on HR-based studies from different perspectives.

Purpose – The purpose of this paper is to investigate the extent of corporate disclosure on human resources (HR) in the annual reports of top performing Indian companies. Design/methodology/approach – The paper explores the extent to which top 82 companies from India present information about HR in their annual reports. This study examines the annual reports of each of the top Indian firms listed on the Bombay stock exchange, using the “content analysis” method. Statistical tests have been performed to analyse the difference between the HR disclosure score across public and private sectors and disclosure variations among various industrial sectors. Findings – In-house training programmes has been noticed to be the favourite item of disclosure followed by safety awards/certifications and statements regarding cordial relations with the employees/unions. A majority of the Indian firms have ignored significant HR issues such as employee welfare fund, maternity/paternity leaves, holiday benefits, employee loans and adopting old age homes, etc. Overall, the study reflects low HR related disclosures. No statistically significant difference has been found between the mean HR disclosure from one industry to another and disclosure practices of the private and the public sector companies. Practical implications – The disclosure pattern of the Indian companies suggests that they only a few companies are concerned about employees’ welfare than the rest. This may motivate a change of the disclosure policy of the rest of the firms who may follow the reporting pattern of the most disclosing ones. Originality/value – This is first study on the disclosure of HR by the Indian corporate sector in the CSR domain with a disclosure analysis for a period of nine years . This research provides new directions for the literature in this area and may promote comparative studies on HR-based studies from different perspectives.

AbstractThe systematics status of the constituent species of the M. mystacinus morphogroup in the Himalayan region has long been marred by uncertainty. Lack of integrative studies combining morphological and genetic data from specimens recently collected in this region has hampered our understanding of cryptic variations in this complex taxonomic group. To address this issue, new material from the Himalayan region of India and Nepal was obtained and vouchered specimens in the holdings of various museums were also re-examined. As comparative material, a large series of relevant specimens from South and Southeast Asia were also included in this revision. Using a combination of multivariate analysis of craniodental characters and molecular reconstructions, we critically evaluated the systematic position of the small Myotinae in the Himalayas. We establish that M. nipalensis forms a very distinct lineage (which also includes the recently described M. annatessae) and refute previous taxonomic suggestions that it is related to M. davidii. Our study also conclusively proved the common occurrence of the poorly known genus Submyotodon in the Himalayan region (Afghanistan, Pakistan, India, Nepal and China) and evidenced species-level divergences within that genus. Submyotodon species share nyctalodont or semi-nyctalodont lower molar configuration with few other small and unrelated Myotinae from Asia suggesting that these unusual dental characters are homoplasious in this subfamily. We also noticed a very confused taxonomic situation associated with many DNA sequences of Asian Myotis deposited in public repositories and call for possibilities of better data curation.

Dengue and Chikungunya are two major arboviral infections transmitted worldwide by the mosquitoes, Aedes aegypti and Ae. albopictus. India suffers enormously with both Dengue and Chikungunya as they pose a great public health challenge. The present study aims to evaluate the prevalence of Dengue Virus (DENV), Chikungunya Virus (CHIKV) and DENV/CHIKV co-infection (by Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR)/Enzyme Linked Immunosorbent Assay (ELISA), their clinical features, DENV serotypes and CHIKV specific Immunoglobulin G (IgG) within a 7 years gap in the Delhi population. The study sample included clinically suspected febrile patients (?7 days) sera collected during 2017-2018 (n=87) and during 2008-2010 (n=623) from Delhi. Captured ELISA was performed for CHIKV IgG screening and nested PCR was done for DENV serotyping. The percentage prevalence for DENV was significantly higher than CHIKV with 41.38% (n=87) and 16.1% (n=87), respectively; interestingly, DENV/CHIKV co-infection was detected in 10.34% (n=9/87) cases during 2017-2018. Similarly, a high DENV prevalence was observed during 2008-2010 with the prevalence rate of 38.3% (69/180), 34.65% (35/101) and 47.07% (161/342), respectively. DENV 1 and DENV 3 were dominant serotype during 2008-2010 and 2017-2018 respectively. We have noticed a high prevalence (36.67%, 22/60) of the CHIKV IgG antibody in the 2017-2018 samples. Joint pain was more preferential to CHIKV mono-infection and DENV/CHIKV co-infection compared to DENV mono-infection. The present study highlights the need for active surveillance simultaneously for both DENV and CHIKV and to evaluate the role of CHIKV/DENV co-infections in disease severity in the endemic regions.

Influence of social capital of inhabitants on shaping common spaces in a housing environment The last two decades of the century have brought unusually many changes in the built environment. These include not only changes directly related to the emergence of a new urban fabric, but also changes in social attitudes towards common spaces located in residential areas. The built environment has never been evaluated so strongly. This assessment translates not only into the everyday outdoor activities of residents (necessary, optional and social activities), but also to economic projects (purchase, sale and rental of real estate). At the same time, the city ceases to be, as it has been so far, mainly subjected to criticism, and the residents are gradually changing their demanding attitude concerning the development of space to participate in the process of its creation. Society wants to have a real impact on urban space, especially on the space closest to them. Thus, the right to the city is no longer a privilege or a duty, but it becomes a need. Trying to meet this need results in a phenomenon which we can increasingly observe in Poland, and which we have been witnessing abroad for many years: activities in public space are changing into activities for public space. They include the transformation of common spaces related to the place of residence—improving their aesthetic quality, functional changes, modernization of development elements. Observing numerous examples of public participation in shaping public spaces, it was noticed that the initiation, course and effects of activities largely depend on the social capital of the group undertaking said activity. Accordingly, there is a need for research on the mutual relation between the level of social capital and the issue of shaping and managing public space with the participation of local communities, which will be the main topic of the paper. To investigate the above-mentioned issue, qualitative research methods were used in relation to the relationship: site visit, non-participant observation and focus interviews. This contributed to a comparative study of three selected Warsaw case studies. They were analysed in terms of meeting the qualitative criteria selected for the study. These criteria have been indicated on the basis of the Social Capital Development Strategy 2020, which is one of the parts of the Medium-Term National Development Strategy. The result of the analyses is an indication of derived factors from within the group of space users and external factors that have a positive and negative impact on initiating, carrying out and maintaining the effects of changes in common spaces developed with the participation of local communities in Polish conditions. The conclusions can be used to improve future participation processes related to urban space - both by non-professionals participating in them, as well as experts - architects and town planners.

Copyright, for a long time has not been regulated or protected at the desired level. The right on intellectual property, as a right of a particular kind and as the right of non-material property, is of particular importance for the contemporary reality.The copyright, in its content, enjoys the rights of personal and property nature. The natural rights, for a long time, have been characterized as very personal rights that relate to the creator of the work itself. This has probably been because in the early times it was impossible the multiplication of the author's work because the handwriting of the work has been a rare process and difficult. Later, with the invention of the typing machine, it was noticed that the works can be easily multiplied, as such came the need to protect the authors and their rights by providing to the authors reward in the case when their work is violated.Property rights are inseparable rights for the authors, which often serve also as stimulus for the creation of new works, but also provide reward for the effort given on the creation of the work.Law on Copyright of theRepublicofKosovois in accordance with the rules of the European Union, but the judicial practice is not in accordance with the Law. This happens because in the reality, the property rights and the moral rights are subject to violations, and as a result is violated even one of the primary and contemporary goals: the law should serve as an incentive for the authors to write and on the other side to satisfy the public with the scientific works.As such, the research objective of this paper is to present the property rights of copyright, the basics of the transfer of these rights, studied also at the comparative aspect.

Being, from the first sight, a complementary part of process management within an organization, process management automation draws a very broad and promising perspective to the whole business field since it is a step closer to the smarter and next level efficiency. Therefore, this particular theoretical scientific research elaborates the topic of the application of Robotic Process Automation (RPA) and Robotic Desktop Automation (RDA) concepts within the work activities in non-manufacturing organizations as this is a non-widely examined area and offers the whole specter of opportunities. Therefore, focuses are based on process management in organizations where client service is key activity and direction with soft systems and operations used as working tools. In addition, a comparative analysis of key similarities and differences of terms and practical application of RPA/RDA within the manufacturing and non-manufacturing sector is provided. Problematic areas, which this particular topic escalates, have a wide framework: first, it is noticed that the scientific field regarding the application of RPA and related concepts in combination with other process management methods (for example, Lean, Agile or Business Process Management (BPM)) has not been widely discussed. Second, in generally most of the past and ongoing scientific researches and practices tendencies and problems in process automation within the manufacturing sector field have been investigated. Accordingly, it is missing both quantitative and qualitative analyses of past and current situations in non-manufacturing business and public organizations. To generalize, it is agreed that process automation has made a notorious impact not only on the tendencies of process management within the business field but also on a society as a human resource. Therefore, investigation of this topic as a very relevant subject is essential since it has a direct and very strong impact on business cycles, technological evolution, and job market.

This article aims to demonstrate the applicability of grounded theory in the analysis of the Museum of the Second World War in Gdańsk in terms of political science. The fundamental question is how to examine the sources which exhibit the ideological character of the space of public museums? In order to answer this question, the concepts by Kathy Charmaz and Adela Clarke are referred to, which have been noticed to offer unused potential for qualitative research conducted in the field of political science. This meant departing from the “classical” versions of grounded theory, created by Barney G. Glaser and Anselm L. Strauss, in favor of what is called “a postmodern turn,” and approaches which synthesize constructivism and social constructionism. Data obtained from primary and secondary sources concerning the main axis of the core exhibition were analyzed. The starting point was my own field research, the results of which were compared with the data from an interview with the museum’s architects and the transcription of a photograph. Inspired by procedures compliant with the non-classical versions of grounded theory, it was demonstrated that the main axis of the core exhibition was designed as a liberal manifesto of freedom. This determined the subject of analysis to be a part of the research field of political science. The spatial solutions applied testified to their designers’ intention to provide visitors with freedom of movement and assembly. They were considered as conceptual categories, related to the absence of a dedicated sightseeing route and the vastness of the space left for visitors. A comparative analysis of codes and categories, however, made it possible to identify yet another interpretative trope, related to the identification of freedom with alienation. In this way, “liberty” has become problematized.

Background and Objective: Data from Indonesia Basic Health Research (2013) states that the chronic renal failure in Indonesia is increasing, especially in Yogyakarta with the prevalence of chronic renal failure of 0,3%. If the patients of chronic renal failure are in End Stage Renal Disease (ESRD), the kidney needs replacement therapy to help its function. This therapy is called Continuous Renal Replacement Therapy (CRRT) or Hemodialysis (HD). Hemodialysis therapy may influence to the imbalance of oxyhemoglobin in the blood. Patients undergoing hemodialysis may experience intradialytic nausea and vomiting. The objective of this study is to identify whether there is a relationship between pre-dialysis oxygenation status through oxygen saturation (SpO2) and respiratory rate (RR) examination and the intradialytic nausea-vomiting occurrence. Method: This research is a comparative research with analytical cross sectional design. This research was conducted in hemodialysis room in Public Hospital of Panembahan Senopati Bantul. The subject of the research was taken using total sampling, by paying attention to research ethics. The total research subjects are 183 respondents. The researchers measured the oxygen saturation and patients’ respiratory rate and examined the intradialytic nausea and vomiting complaints. Result: The analysis result of Fisher’s exact in this research shows p value of 0,000 both in bivariate analysis of oxygen saturation to the nausea and vomiting occurrence and in bivariate analysis of the respiratory rate to the nausea and vomiting occurrence. The multivariate analysis employing regression logistic shows that the OR of oxygen saturation is 73,57, this means that the measurement of the abnormal oxygen saturation has the chance of seventy three times more to the nausea and vomiting occurrence, if compared to the patients with normal oxygen saturation. Conclusion and Suggestion: Intradialytic nausea and vomiting is one of the causes of the imbalance of oxyhemoglobin. The readiness of pre-dialysis oxygenation status needs to be noticed so that the nausea and vomiting complaints can be anticipated earlier.

The purpose of the article consists of complex research political and administrative aspects of the influence of the political system and activity of political parties on the forming of democratic principles of community development. During research uses on the complex of logical methods, in particular, comparatively-political, abstractly logical, and also scientific approaches: comparatively and bibliographic. In the article, complex research is presented politiсal-administrative aspects of the influence of the political system and activity of political parties on forming of democratic principles of community development. It is noticed that the determining line of the functioning of any political system is its interconnectedness with other subsystems of society, that is why national features have a degree of its democratizes and becoming a problem, and a method of functioning of power is the determining criterion of typologies of the political systems. Therefore at the research of influence of the political system on forming of democratic principles of community development, in particular, it is necessary to examine the aggregate of political institutes, relations and political and legal relations, which public relations are regulated by, viability and efficiency of functioning of that or other are provided as a system influence of which on development of the indicated principles is provided an implementation of its functions (normatively regulatory, informatively communicative et al). Is it set that becoming of the democratic system of public management in Ukraine remains foreground job of nowadays and factors which brake indicated becoming are at the same time selected, among which, in particular, disunity national elite, weakness of political institutes, political corruption. It allowed to come to the conclusion, that success of decision of this task on the domestic walks of life substantially depends on the combination of advantages of conservative and democratic types of acceptance and realization political-administrative decisions, which are examined as the quintessence of satisfaction of political requirements of individuals, task forces, and others like that in the process of adjusting of social relations. Taking into account its attention is accented on importance of prevailing foremost of state character in the activity of political parties, as main subjects of forming of political space, institutes of the state and optimization, politicaladministrative processes, what in Ukraine is not observed, that is the main factor of low efficiency of mechanism of responsibility of political power before electors. The scientific novelty of the article consists of execution complex research politiсal-administrative aspects of the influence of the political system and activity of political parties on forming democratic principles of community development. Practical meaningfulness of the article is related to the possibility of the subsequent use of its materials in an educational process and research secret services at research political-administrative aspects of the influence of the political system and activity of political parties on becoming of the modern system of democratic governance in Ukraine in the context of found out factors which generate considerable difficulties in relation to becoming of the indicated system on the domestic walks of life.

In this critically insightful and highly readable book of political ethnogra- phy, Aisha Ahmad, a political scientist at University of Toronto, seeks to explain how and why Islamist movements continue to militarily prevail and politically succeed in forming proto-states, over clan, ethnic, and/or tribal based competitions, amidst the chaos and disorder of civil wars across the contemporary Muslim world, from Mali to Mindanao. To this end, Ahmad seeks to go beyond the usual expositions that center the explanatory power of Islamist ideologies and identities, which dominate the scholarly fields of political science, international relations, security studies as well as the global public discourse shaped by journalists, politicians, and the punditry of shouting heads everywhere. Through a deep, immersive study of power in Afghanistan and Soma- lia, Ahmad demonstrates the profoundly symbiotic relationship between Islamists and the local business class. While recognizing the interconnec- tions between violent conflict and illicit trade is nothing new, Ahmad’s explication of the economic logics of Islamist proto-states furnishes a nov- el two-stage dynamic to explain the indispensability and ubiquity of this Islamist-business alliance in conflict zones. The first is the gradual social process of conversion of the business class’ worldview and practice to align them with Islamist identity formations, which is “aimed at mitigating un- certainty and improving access to markets” (xvii). Alongside this long-term socialization is a second, short-term political-economic dynamic of rapid shift in the business class’s collective patronage of a new Islamist faction, based on the assumption that it will lower the cost of business. The for- midable alliance between business class interests and Islamist institutions brings forth the new Islamist proto-state. Chapter one of the book adum- brates this two-stage argument and offers justifications for the two case studies, namely the Taliban in Afghanistan and the Islamic Courts Union in Somalia. The second chapter unpacks the two-stage dynamic in detail. We learn that in modern civil wars across the Muslim world, business communi- ties intentionally adopt ardent Islamist identities as a practical means to- ward building trust and lowering cost. Islamist factions, aspiring toward hegemony, offer the possibility of economic relationships that transcend the ethnic boundaries which limit rival factions rooted in clan, tribal, or ethno-linguistic social formations. This leads to the second, faster conver- gence of business-Islamist interests, wherein the Islamist groups leverage their broader social identity and economic market to offer stronger secu- rity at a lower cost. This development of an economy of scale leads the local business elites to throw their financial support behind the Islamists at a critical juncture of militant competition. Once this threshold is met, Islamist factions rapidly conquer and consolidate territories from their rel- atively socially constrained rivals to form a new proto-state, like the Taliban regime and the Islamic Courts Union (ICU). When we look at the timeline of their development (the Taliban in 1994 and the ICU in 2006), we notice a similar length of gestation, about 15 years of war. This similarity may be coincidental, but the political-military threshold is the same. Both societ- ies, ravaged by civil war, reached a stalemate. At this critical juncture the positional properties of Islamist formations in the field of civil war factions gives the Islamists a decided economic (cost analysis) and social (trust building across clan/tribal identities) advantage. Chapters three to six examine each of the two processes for the se- lected sites of inquiry. Thus chapters three and five, respectively, explore the long-term Islamist identity construction within the smuggling industry in the Afghanistan-Pakistan borderland, and the Somali business elites’ gradual convergence with Islamists. In chapter four, Ahmad explores the second dynamic in the context of rising security costs during the Afghan civil war. Mullah Omar’s Taliban provided the order and security across the borderland that had previously eluded the variety of industries. This allowed the Taliban to expand on the backs of voluntary donations, rather than extortions like their rival tribal warlords, which in turn allowed them to recruit and retain more disciplined fighters (81). The source of these donations was the business class, especially those involved in the highly lucrative transit trade, which, before the rise of Taliban, paid immense op- portunity cost at the hands of rapacious local and tribal warlord fiefdoms and bandits. Instead of the multitude of checkpoints crisscrossing south- ern Afghanistan and the borderlands, the Taliban presented a simplified administration. While the rest of the world took notice of their repressive measures against women’s mobility, education, and cultural expression, the men of the bazaar appreciated the newly acquired public safety to ply their trade and the lowered cost of doing business. Chapter six, “The Price of Protection: The Rise of the Islamic Courts Union,” demonstrates a similar mutually beneficial Islamist-business relationship emerging out of the incessant clan-based militia conflicts that had especially plagued southern Somalia since the fall of the last national government in 1991. Businesspeople, whether they were tycoons or small business owners, had to pay two types of tax. First was what was owed to the local racket or warlord, and the second was to the ever-fragmenting sub-clan militias and their checkpoints on the intercity highways. Unlike their rival, the Transitional Federal Government (TGF), ICU forged their supra-clan institutional identity through a universalist legal discourse and practice rooted in Islamic law and ethics. They united the courts and their associated clan-based militias, including al-Shabaab. Ahmad demonstrates, through a synthesis of secondary literature and original political ethnogra- phy, the economic logics of ICU’s ability to overcome the threshold of ma- terial and social support needed to establish the rule of law and a far-reach- ing functioning government. If the Taliban and the ICU had solved the riddle of creating order and security to create hegemonic proto-states, then what was their downfall? Chapter seven gives us an account of the international interventions that caused the collapse of the two proto-states. In the aftermath of their de- struction, the internationally supported regimes that replaced them, de- spite immense monetary and military aid, have failed to gain the same level of legitimacy across Afghanistan and Somalia. In chapter eight, Ahmad expands the scope of analysis to North/Western Africa (Al-Qaeda in the Is- lamic Maghrib: AQIM), Middle East (Islamic State in Iraq and Syria: ISIS), and South Asia (Tahrik-i Taliban-i Pakistan: TTP). At the time of this book’s publication, these movements were not yet, as Ahmad posits, closed cases like the Taliban and the ICU. Thus, the data from this chapter’s comparative survey furnishes suggestive arguments for Ahmad’s larger thesis, namely that Islamist proto-states emerge out of a confluence of economic and security interests rather than mere ideological and identity politics. The epistemic humility of this chapter signals to this reader two lines of constructive criticism of some aspects of Ahmad’s sub- stantiation of this thesis. First, the juxtaposing of Islamist success against their clan-/tribal iden- tity-based rivals may be underestimating the element of ethnic solidarity in those very Islamists’ political success. The most glaring case is the Taliban, which in its original formation and in its post-American invasion frag- mentations, across the Durand Line, was more or less founded on a pan- or-tribal Pashtun social identity and economic compulsions relative to the other Afghan ethno-linguistic communities. How does one disaggregate the force of ethnic solidarity (even if it is only a necessary condition, rather than a cause) from economic calculus in explaining the rise of the Taliban proto-state? The second issue in this juxtaposition is that when we compare a suc- cessful Islamist movement against socially limited ethnocentric rivals, we discount the other Islamist movements that failed. Explanations for those Islamists that failed to create a proto-state along the lines of the ICU or the Taliban, such as al-Ittihad al-Islamiyya (Somalia) or Gulbuddin Hekmat- yar’s Hezb-e Islami (Afghanistan), needed to be more robustly taken into account and integrated into the substantiation of Ahmad’s thesis. Even in the section on ISIS, it would have been helpful to integrate the case of Jabhat al-Nusra’s (an al-Qaeda affiliate in Syria) inability to create a proto-state to rival ISIS. We must ask, why do some Jihadi Islamist movements prevail against each other and why do others fail? Perhaps some of these Islamist movements appear too early to scale up their operation (i.e., they precede Ahmad’s ‘critical juncture’), or they were too embroiled and too partisan in the illicit trade network to fully leverage their Islamist universalism to create the trust and bonds that are the first part of Ahmad’s two-stage dy- namic. Possible answers would need to complement Ahmad’s excellent po- litical ethnography with deeper quantitative dives to identify the statistical variations of these critical junctures: when does the cost of warlords and mafias’ domination outweigh the cost of Islamist-Jihadi movements’ social- ly repressive but economically liberating regimes? At which point in the social evolution of society during an unending civil war do identities forged by the bonds of blood give way to those imagined through bonds of faith? These two critical suggestions do not diminish Ahmad’s highly teach- able work. This book should be read by all concerned policy makers, schol- ars in the social sciences and humanities, and anyone who wants to go be- yond ‘culture talk’ historical causation by ideas and identity and uncover structuralist explanations for the rise of Jihadi Islamist success in civil wars across the Muslim world. It is especially recommended for adoption in cog- nate courses at the undergraduate level, for its combination of erudition and readability. Maheen ZamanAssistant ProfessorDepartment of HistoryAugsburg University

In this critically insightful and highly readable book of political ethnogra- phy, Aisha Ahmad, a political scientist at University of Toronto, seeks to explain how and why Islamist movements continue to militarily prevail and politically succeed in forming proto-states, over clan, ethnic, and/or tribal based competitions, amidst the chaos and disorder of civil wars across the contemporary Muslim world, from Mali to Mindanao. To this end, Ahmad seeks to go beyond the usual expositions that center the explanatory power of Islamist ideologies and identities, which dominate the scholarly fields of political science, international relations, security studies as well as the global public discourse shaped by journalists, politicians, and the punditry of shouting heads everywhere. Through a deep, immersive study of power in Afghanistan and Soma- lia, Ahmad demonstrates the profoundly symbiotic relationship between Islamists and the local business class. While recognizing the interconnec- tions between violent conflict and illicit trade is nothing new, Ahmad’s explication of the economic logics of Islamist proto-states furnishes a nov- el two-stage dynamic to explain the indispensability and ubiquity of this Islamist-business alliance in conflict zones. The first is the gradual social process of conversion of the business class’ worldview and practice to align them with Islamist identity formations, which is “aimed at mitigating un- certainty and improving access to markets” (xvii). Alongside this long-term socialization is a second, short-term political-economic dynamic of rapid shift in the business class’s collective patronage of a new Islamist faction, based on the assumption that it will lower the cost of business. The for- midable alliance between business class interests and Islamist institutions brings forth the new Islamist proto-state. Chapter one of the book adum- brates this two-stage argument and offers justifications for the two case studies, namely the Taliban in Afghanistan and the Islamic Courts Union in Somalia. The second chapter unpacks the two-stage dynamic in detail. We learn that in modern civil wars across the Muslim world, business communi- ties intentionally adopt ardent Islamist identities as a practical means to- ward building trust and lowering cost. Islamist factions, aspiring toward hegemony, offer the possibility of economic relationships that transcend the ethnic boundaries which limit rival factions rooted in clan, tribal, or ethno-linguistic social formations. This leads to the second, faster conver- gence of business-Islamist interests, wherein the Islamist groups leverage their broader social identity and economic market to offer stronger secu- rity at a lower cost. This development of an economy of scale leads the local business elites to throw their financial support behind the Islamists at a critical juncture of militant competition. Once this threshold is met, Islamist factions rapidly conquer and consolidate territories from their rel- atively socially constrained rivals to form a new proto-state, like the Taliban regime and the Islamic Courts Union (ICU). When we look at the timeline of their development (the Taliban in 1994 and the ICU in 2006), we notice a similar length of gestation, about 15 years of war. This similarity may be coincidental, but the political-military threshold is the same. Both societ- ies, ravaged by civil war, reached a stalemate. At this critical juncture the positional properties of Islamist formations in the field of civil war factions gives the Islamists a decided economic (cost analysis) and social (trust building across clan/tribal identities) advantage. Chapters three to six examine each of the two processes for the se- lected sites of inquiry. Thus chapters three and five, respectively, explore the long-term Islamist identity construction within the smuggling industry in the Afghanistan-Pakistan borderland, and the Somali business elites’ gradual convergence with Islamists. In chapter four, Ahmad explores the second dynamic in the context of rising security costs during the Afghan civil war. Mullah Omar’s Taliban provided the order and security across the borderland that had previously eluded the variety of industries. This allowed the Taliban to expand on the backs of voluntary donations, rather than extortions like their rival tribal warlords, which in turn allowed them to recruit and retain more disciplined fighters (81). The source of these donations was the business class, especially those involved in the highly lucrative transit trade, which, before the rise of Taliban, paid immense op- portunity cost at the hands of rapacious local and tribal warlord fiefdoms and bandits. Instead of the multitude of checkpoints crisscrossing south- ern Afghanistan and the borderlands, the Taliban presented a simplified administration. While the rest of the world took notice of their repressive measures against women’s mobility, education, and cultural expression, the men of the bazaar appreciated the newly acquired public safety to ply their trade and the lowered cost of doing business. Chapter six, “The Price of Protection: The Rise of the Islamic Courts Union,” demonstrates a similar mutually beneficial Islamist-business relationship emerging out of the incessant clan-based militia conflicts that had especially plagued southern Somalia since the fall of the last national government in 1991. Businesspeople, whether they were tycoons or small business owners, had to pay two types of tax. First was what was owed to the local racket or warlord, and the second was to the ever-fragmenting sub-clan militias and their checkpoints on the intercity highways. Unlike their rival, the Transitional Federal Government (TGF), ICU forged their supra-clan institutional identity through a universalist legal discourse and practice rooted in Islamic law and ethics. They united the courts and their associated clan-based militias, including al-Shabaab. Ahmad demonstrates, through a synthesis of secondary literature and original political ethnogra- phy, the economic logics of ICU’s ability to overcome the threshold of ma- terial and social support needed to establish the rule of law and a far-reach- ing functioning government. If the Taliban and the ICU had solved the riddle of creating order and security to create hegemonic proto-states, then what was their downfall? Chapter seven gives us an account of the international interventions that caused the collapse of the two proto-states. In the aftermath of their de- struction, the internationally supported regimes that replaced them, de- spite immense monetary and military aid, have failed to gain the same level of legitimacy across Afghanistan and Somalia. In chapter eight, Ahmad expands the scope of analysis to North/Western Africa (Al-Qaeda in the Is- lamic Maghrib: AQIM), Middle East (Islamic State in Iraq and Syria: ISIS), and South Asia (Tahrik-i Taliban-i Pakistan: TTP). At the time of this book’s publication, these movements were not yet, as Ahmad posits, closed cases like the Taliban and the ICU. Thus, the data from this chapter’s comparative survey furnishes suggestive arguments for Ahmad’s larger thesis, namely that Islamist proto-states emerge out of a confluence of economic and security interests rather than mere ideological and identity politics. The epistemic humility of this chapter signals to this reader two lines of constructive criticism of some aspects of Ahmad’s sub- stantiation of this thesis. First, the juxtaposing of Islamist success against their clan-/tribal iden- tity-based rivals may be underestimating the element of ethnic solidarity in those very Islamists’ political success. The most glaring case is the Taliban, which in its original formation and in its post-American invasion frag- mentations, across the Durand Line, was more or less founded on a pan- or-tribal Pashtun social identity and economic compulsions relative to the other Afghan ethno-linguistic communities. How does one disaggregate the force of ethnic solidarity (even if it is only a necessary condition, rather than a cause) from economic calculus in explaining the rise of the Taliban proto-state? The second issue in this juxtaposition is that when we compare a suc- cessful Islamist movement against socially limited ethnocentric rivals, we discount the other Islamist movements that failed. Explanations for those Islamists that failed to create a proto-state along the lines of the ICU or the Taliban, such as al-Ittihad al-Islamiyya (Somalia) or Gulbuddin Hekmat- yar’s Hezb-e Islami (Afghanistan), needed to be more robustly taken into account and integrated into the substantiation of Ahmad’s thesis. Even in the section on ISIS, it would have been helpful to integrate the case of Jabhat al-Nusra’s (an al-Qaeda affiliate in Syria) inability to create a proto-state to rival ISIS. We must ask, why do some Jihadi Islamist movements prevail against each other and why do others fail? Perhaps some of these Islamist movements appear too early to scale up their operation (i.e., they precede Ahmad’s ‘critical juncture’), or they were too embroiled and too partisan in the illicit trade network to fully leverage their Islamist universalism to create the trust and bonds that are the first part of Ahmad’s two-stage dy- namic. Possible answers would need to complement Ahmad’s excellent po- litical ethnography with deeper quantitative dives to identify the statistical variations of these critical junctures: when does the cost of warlords and mafias’ domination outweigh the cost of Islamist-Jihadi movements’ social- ly repressive but economically liberating regimes? At which point in the social evolution of society during an unending civil war do identities forged by the bonds of blood give way to those imagined through bonds of faith? These two critical suggestions do not diminish Ahmad’s highly teach- able work. This book should be read by all concerned policy makers, schol- ars in the social sciences and humanities, and anyone who wants to go be- yond ‘culture talk’ historical causation by ideas and identity and uncover structuralist explanations for the rise of Jihadi Islamist success in civil wars across the Muslim world. It is especially recommended for adoption in cog- nate courses at the undergraduate level, for its combination of erudition and readability. Maheen ZamanAssistant ProfessorDepartment of HistoryAugsburg University

Introduction: The threat of the premature birth (TPB) raises a problem of public health in Benin in general and in Parakou in particular. Objective: The aim of this research paper is to compare the efficiency of salbutamol and nifedipine in the treatment of the threat of premature birth at the maternity hospital of CHUD-Borgou. Framework and methodological approach: It is about a comparative prospective study with analytical view, within a period of six (06) months, going from 1, March 2016 to 1, September 2016. The target population is composed of all the pregnant women admitted to the maternity hospital of CHUD-B during the period of the study. Results: The 60 pregnant women have been divided into two groups of 30 pregnant women. The average age of the pregnant women is 26.50 years with the extremes of 16 years and 38 years. The women who have between two and three pregnancies are the most represented with 56.67% of the cases; just as much as the women who have between two and three deliveries with 36.67%. From the total number, 21. 67% had antecedents of spontaneous miscarriages and 6, 67% antecedents of premature birth delivery. With 90% of the cases, the gestational age is between 28 weeks of amenorrhoea and 33weeks of amenorrhoea plus six (06) days. The pregnancy is twin in 16.67% of the cases. At the admission, 90% of the cases after assessment of the Coefficient of Risk of Premature birth Delivery. (CRPD), had a potential risk of prematurity and 85% had a score of Baumgarten between 3 and 6. The most discovered aetiology is malaria with 46.67% of the pregnant women. The side effect of usage of nifedipine, in order to relieve the uterus, has been noticed with 16.67% pregnant women who have received nifedipine treatment against 30% pregnant women who have received the treatment of Salbutamol. There is no difference statistically significant. For the nifedipine, there is 90% of success against 10% of failure. For salbutamol, there is respectively 56.67% and 43.33%. We have no case of intolerance. Conclusion: The study shows neat efficiency of nifedipine in relation to salbutamol during the treatment of the threats of premature birth delivery.

Purpose – The present article aims to analyze the content of process prioritization methods and possibilities of its application in the context of Mass Customization. Design/methodology/approach – As the analysis is based on exploratory approach, qualitative methodology is the main tool used in the research. Moreover, author do not aim at providing conclusive answers to research questions; in opposition, generating relevant insights about a current situation is a goal. Findings – Results suggest that prioritization methods and principles are compatible, necessary and can be successfully applicable to Mass Customization at different process stages or even this concept types. In addition, this research reveals the need to have a combined and multidimensional prioritization at the beginning of Mass Customization processes. Research limitations/implications – Main research limitations can be divided into two parts. Firstly, when prioritization is taken into consideration, it is noticed that a limited scope of research focus on combined prioritization models as well as their effect on organizations results, especially in Public and Non-governmental sector. Secondly, in a case of concept of Mass Customization and its analysis, scientific discussions show extremum transitions to Big Data, Internet platform capabilities and overall customer flow management via modern economic theories in the last decades. Therefore, a lack of sufficient scientific attention to important parts of prioritization severely affect customer input, Design and Infrastructure of Mass Customization. In addition, both parts require not only proper understanding of the theoretical background but also following detail description of practical implication tools and guidelines as well as defining possible application effect. Since this article is based on the theoretical literature review, case studies and comparative analysis towards a practical implication are elaborated briefly. Practical implications – This research may serve as relevant insights into the context of the Mass Customization system and processes, where organizations constantly cope with prioritization by making a number of decisions on product selection, specifications, quantities, or pricing. From the perspective of process prioritization, the research serves as a concise review of main quantitative and qualitative methods, showing their demand of alignment and effect for Mass Customization. Originality/Value – The main value of the presented article can be described as a holistic theoretical focus on different types of prioritization methods and underlying points where it takes effect in Mass Customization concept. Moreover, the selected research object and findings are also valuable and applicable for organizations of different type, sector and working field Keywords: process prioritization, optimization, combined methods, Mass Customization Research type: general review. JEL classification: M19.

Apresentamos neste artigo um estudo comparado das manchetes publicadas no jornal O Estado do Maranhão em 2014, último ano do governo Roseana Sarney, e 2015, primeiro ano do governo Flávio Dino, sobre a atuação dos dois governadores. O objetivo do trabalho é analisar a mudança editorial do jornal, que praticava um jornalismo publicitário em favor do governo de Roseana e passou a praticar o jornalismo adversário durante o governo Dino. A metodologia utilizada foi uma combinação de análise de valência, análise linguística e análise da narrativa. Os resultados mostram que o jornal, embora seguindo os critérios de noticiabilidade e valores-notícia, posicionava-se como relações-públicas do governo Roseana e atua como ator político de oposição ao governo Dino. PALAVRAS-CHAVE: Jornalismo; Narrativa; Roseana Sarney; Flávio Dino. ABSTRACT This article presents a comparative study of the headlines published in the newspaper O Estado de Maranhão in 2014, the last year of the Roseana Sarney administration, and 2015, the first year of the Flávio Dino government, on the performance of the two governors. The purpose of the paper is to analyze the editorial change of O Estado do Maranhão, which practiced an advertising journalism during the Roseana government and began to practice adversarial journalism during the Dino government. The methodology used was a combination of valence analysis, linguistic analysis and narrative analysis. The results show that the newspaper, although following the noticiability criteria and news-values, positioned itself like public relations of the Roseana government and acts like political actor of opposition to the Dino government. KEYWORDS: Journalism; Narrative; Roseana Sarney; Flávio Dino. RESUMEN En este artículo se presenta un estudio comparado de los titulares publicados en el diario O Estado de Maranhão en 2014, último año del gobierno Roseana Sarney, y 2015, primer año del gobierno Flávio Dino. El objetivo del trabajo es analizar el cambio editorial del periódico, que practicaba un periodismo publicitario en favor del gobierno de Roseana y pasó a practicar el periodismo adversario durante el gobierno Dino. La metodología utilizada fue una combinación de análisis de valencia, análisis lingüístico y análisis de la narrativa. Los resultados muestran que el periódico, aunque siguiendo los criterios de noticiabilidad y valores-noticia, se posicionaba como relaciones públicas del gobierno de Roseana y actúa como actor político de oposición al gobierno de Dino. PALABRAS CLAVE: Periodismo; Narrativa; Roseana Sarney; Flávio Dino.

Abstract: The main aims of this observation are (1) to find out is there any significant increasing of economic structure in Aceh Besar and (2) to examine the issues of base sector for the economy in Aceh Besar during period 2010-2015. The analysis methods applied in this study are Shift Share Analysis, Shift Share Modification Esteban Marquillas and Location Quotient. The results of the study analysis found was transformation of economic structure from primary sector to secondary sector in Aceh Besar. While the contribution of of secondary sector, primary sector and then tersier sector which had contributed to PDRB in Aceh Besar continously. The base sector which is based on shift share analysis and location quotient analysis are including retail sector; repair of motor vehicles, transportation and storage sector. Agriculture, forestry and fishing sectors are not including to this sector which has comparative advantages, even though the contribution of economic structure of Aceh Besar is still dominated of those sectors. In fact agriculcural sector is not priority sector to be main sector in Aceh. The district government of Aceh Besar is expected to be more notice and promote the sector tertier such as retail trading sector; repair of motor, transportation and storage sector. Agriculture, forestry and fishing, and also accommodation and infrastructures. For those who have the authorities are also expected to be more concern in developing economic sectors which are belonging to Aceh. This issues can be solved through strategic policy in order to extend economic sector.Keywords: Structural Economic, Base Sector, Location quotient (LQ)Abstrak: Tujuan utama dari penelitian ini adalah (1) untuk mengetahui terjadinya pergeseran struktur ekonomi di Kabupaten Aceh dan (2) untuk mengetahui sektor basis atau sektor unggulan dalam perekonomian Kabupaten Aceh Besar selama periode 2010- 2015. Metode penelitian ini menggunakan pendekatan Analisis Shift Share Klasik, Analisis Shift Share Esteban-Marquillas dan Location Quotient (LQ). Hasil analisis menunjukkan bahwa telah terjadi perubahan struktur ekonomi di Kabupaten Aceh Besar dari sektor primer ke sektor sekunder. Hal ini ditunjukkan dengan peranan sektor sekunder yang terus meningkat melalui besarnya kontribusi terhadap PDRB kabupaten Aceh Besar. Sektor unggulan berdasarkan analisis shift share dan location quotient adalah sektor perdagangan besar dan eceran; reparasi mobil dan sepeda motor dan sektor transportasi dan pergudangan. Sektor pertanian, kehutanan, dan perikanan tidak termasuk sebagai sektor yang memiliki keunggulan komparatif (nilai LQ rendah), walaupun bila dilihat secara kontribusi struktur ekonomi kawasan Aceh Besar masih didominasi oleh sektor pertanian, kehutanan dan perikanan, namun nyatanya sektor ini belum betul-betul menjadi andalan prioritas kebijakan pemerintah daerah dalam menjadikan pertanian sebagai sentral utama. Diharapkan kepada Pemerintah Daerah Aceh Besar sebaiknya memperhatikan dan mengembangkan sektor tertier, misalnya perdagangan besar dan eceran; reparasi mobil dan sepeda motor dan sektor transportasi dan pergudangan. serta sarana dan prasarana penunjang lainnya. Dan kepada pengambil kebijakan juga untuk dapat lebih memperhatikan dan mengembangkan sektor-sektor ekonomi yang ada di Aceh. Ini dapat dilakukan dengan mengeluarkan kebijakan-kebijakan yang pro-potensial untuk pengembangan sektor ekonomi. Misalnya pada sektor pertanian perlu lebih didukung untuk menjadikan sebagai agrowisata ataupun agroindustri yang dapat mengolah dan mengatur output sektor tersebut, sektor industri pengolahan perlu didukung dengan menfasilitasi industri pendukung sektor ini, sektor bangunan perlu didukung dengan kemudahan pemberian izin bagi sarana untuk kemanfaatan publik dan lain sebagainya.Kata Kunci : Struktur Ekonomi, Sektor Ekonomi Unggulan, Location Quotient (LQ)

With the aim of understanding the insertion of higher education into a new context of organization of society and State, which is managed according to the New Public Management, this work presents a comparative historical study of the organization of French and Brazilian higher education. It is concluded that the French adherence to the New Public Management is based on the knowledge economy, while the Brazilian one is based on State size reduction along the lines of the Washington Consensus; in addition, higher education institutions in both countries are organized to participate in competitions: in France, the international competition promoted by rankings, and in Brazil, the market competition.ResumoCom o objetivo de compreender a inserção do ensino superior dentro de um novo contexto de organização da sociedade e do Estado, gerido pela Nova Gestão Pública, o trabalho apresenta um estudo histórico comparativo da organização do ensino superior brasileiro e o francês. Conclui-se que a adesão francesa à Nova Gestão Pública tem como norte a economia do conhecimento, e a brasileira, a redução do Estado nos moldes do Consenso de Washington; e que as instituições de ensino superior nos dois países são organizadas para participarem de concorrências: na França, a internacional promovida pelos ranqueamentos, no Brasil, a mercantil.Palavras-chave: Ensino superior brasileiro, Ensino superior francês, Nova gestão pública, Universidade.Keywords: Brazilian higher education, French higher education, New public management, University.ReferencesAEBISCHER, S. Réinventer l'école, réinventer l'administration. Une loi pédagogique et managériale au prisme de ses producteurs. Politix, n. 98, n.2 p. 57-83 2012/2.AERES. Repères historiques. Agence d’évaluation de la recherche et de l’enseignement supérieur. Disponível em: <www.aeres-evaluation.fr/Agence/Presentation/Reperes-historiques>. Acesso em: 17 nov. 2016.AMARAL, N. C. 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Recent evidence suggests immunomodulatory effects of daratumumab in heavily pre-treated Multiple Myeloma (MM) patients (pts); however, the precise effects remain under-characterized, particularly at the molecular level. REBUILD is an ongoing prospective, multicenter, non-comparative, open-label, phase II study that evaluates the effects of daratumumab monotherapy on bone metabolism of pts with relapsed and/or refractory MM (RRMM) who have had ≥2 prior lines of therapy, including lenalidomide and a proteasome inhibitor. Secondary endpoint of the study included the evaluation of T cell dynamics by comprehensive analysis of the T cell receptor (TR) repertoire employing next generation sequencing (NGS) and multi-color flow cytometry. Herein we report the results of this secondary endpoint for the first 14 pts who completed 3 cycles of daratumumab monotherapy. In total, we analyzed 28 paired samples collected at screening (n=14) and on Day 1 of Cycle 4 (C4D1, n=14) of treatment in order to assess potential changes in relation to treatment and clinical response. Patients were grouped based on best responses into responders (i.e. patients with partial response [PR, n=1] and very good PR [VGPR, n=6]), and non-responders (i.e. patients with minimal response [MR, n=2], stable disease [SD, n=4], or progressive disease [PD, n=1]). Starting material was peripheral blood mononuclear cells. TRBV-TRBD-TRBJ gene rearrangements were RT-PCR amplified and subjected to paired-end NGS. Raw NGS reads (n=6,715,406 | median 221,145/sample) were processed through a previously published, purpose-built bioinformatics pipeline. Only productive TRBV-TRBD-TRBJ rearrangements were taken into consideration (n=3,097,565 | median 101,670/sample) for the computation of clonotypes (i.e. TRB rearrangements with identical TRBV gene usage and amino acid complementarity-determining region 3 sequence). Overall, 151,153 distinct clonotypes (median 5,084 clonotypes/sample) were assessed. Both groups (responders/non-responders) displayed clonal T cell expansions both pre- and post-treatment. Clonality was found to be increased after treatment for both responders and non-responders, with statistical significance in the former (median cumulative frequency of the 10 most expanded T cell clonotypes/sample: 31% pre-treatment versus 40% post-treatment, respectively | p=0.04). In both groups, the clonotype repertoire appeared to be renewed with only a small fraction of pre-treatment clonotypes remaining after treatment (1% for non-responders; 0.6% for responders). Interestingly, in the responders' group we noticed a significant shift in the major clonotype repertoire at screening vs C4D1. In particular, in the responders' group the 10 most expanded clonotypes/sample at C4D1 represented expansions of clonotypes present at very low frequency at screening, whereas the most expanded clonotypes at screening decreased or even diminished post-treatment, suggesting that daratumumab treatment led to the emergence of anti-myeloma T cell clones which contributed to clinical response. On the contrary, the 10 most expanded pre-treatment clonotypes in the non-responders' group tended to dominate also the post-treatment repertoire. Of note, 13 shared clonotypes were identified amongst the post-treatment repertoires of different patients (responders/non-responders); shared clonotypes were not found in other entities in public databases, raising the possibility that they may be "disease-specific" and selected by common tumor-associated antigens. With a single exception, shared clonotypes were detected in cases with relevant HLA restrictions, which is noteworthy given the random HLA background of our cohort. Finally, flow cytometry analysis revealed a significant increase post treatment in the percentage of CD3+ T cells (median frequency at screening 60% versus 83% at C4D1 | p=0.003), driven mostly by the expansion of the CD8+ T cell compartment (median frequency at screening 30.8% versus 48.9% at C4D1 | p=0.03) in both groups. In conclusion, TR clonality increases post-treatment through a renewal mechanism; however, pre-treatment clones significantly expanded post-treatment in responders, alluding to the existence of clonotypes with anti-MM properties that may be activated after treatment with daratumumab, arguably contributing to clinical response. Disclosures Kastritis: Janssen: Honoraria, Research Funding; Takeda: Honoraria; Pfizer: Honoraria; Prothena: Honoraria; Genesis: Honoraria; Amgen: Honoraria, Research Funding. Hatjiharissi:Janssen: Honoraria. Katodritou:Genesis: Honoraria; Janssen: Honoraria; Takeda: Honoraria; Amgen: Honoraria. Gavriatopoulou:Genesis: Honoraria, Other: Travel expenses; Janssen: Honoraria, Other: Travel expenses; Takeda: Honoraria, Other: Travel expenses; Amgen: Honoraria. Delimpasi:Takeda: Honoraria; Amgen: Honoraria; Janssen: Honoraria; Genesis: Honoraria, Other: Travel grant. Symeonidis:Sanofi: Research Funding; MSD: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Research Funding; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Roche: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead: Membership on an entity's Board of Directors or advisory committees, Research Funding; Tekeda: Membership on an entity's Board of Directors or advisory committees, Research Funding. Stamatopoulos:Janssen: Honoraria, Research Funding; Abbvie: Honoraria, Research Funding. Dimopoulos:Sanofi Oncology: Research Funding. Terpos:Janssen: Honoraria, Other: Travel expenses, Research Funding; Medison: Honoraria; Genesis: Honoraria, Other: Travel expenses, Research Funding; Amgen: Honoraria, Research Funding; Celgene: Honoraria; Takeda: Honoraria, Other: Travel expenses, Research Funding. Chatzidimitriou:Janssen: Honoraria.

Preliminary evidence for T cell receptor (TR) repertoire renewal and increased TR clonality has been reported by our group (Vlachonikola et al., ASH 2019) in multiple myeloma (MM) patients (pts) receiving daratumumab monotherapy within the context of the REBUILD study, an ongoing prospective, multicenter, non-comparative, open-label, phase II study in pts with relapsed and/or refractory MM (RRMM) who have had ≥2 prior lines of therapy, including lenalidomide and a proteasome inhibitor. Herein, we report the results from the longitudinal analysis of the TR repertoire employing next generation sequencing (NGS) and multi-color flow cytometry in 24 pts who completed 3 cycles (n=24) and 6 cycles (n=11/24) of daratumumab monotherapy, in order to assess the immunomodulatory effects of daratumumab. We assessed 59 peripheral blood samples collected at screening (SCR, n=24), on Day 1 of Cycle 4 (C4, n=24) and Day 1 of Cycle 7 (C7, n=11). Patients were grouped based on best responses at C4 into responders (i.e. pts with partial response [PR, n=7] and very good PR [VGPR, n=8]), and non-responders (i.e. pts with minimal response [MR, n=2], stable disease [SD, n=5], or progressive disease [PD, n=2]). TRBV-TRBD-TRBJ gene rearrangements were subjected to paired-end NGS and raw reads (n=13,886,646 | median 239,969/sample) were processed through a purpose-built bioinformatics pipeline. Productive TRBV-TRBD-TRBJ rearrangements were taken into consideration (n=6,324,986 | median 100,738/sample) for the computation of clonotypes (i.e. TRB rearrangements with identical TRBV gene usage and amino acid complementarity-determining region 3 sequence). Overall, 325,789 distinct clonotypes (median 4,535 clonotypes/sample) were analyzed. The TR repertoire displayed clonal T cell expansions in both groups (responders/non-responders) in all pre/post-treatment timepoints. Clonality increased after treatment for both responders and non-responders in all assessed timepoints, with statistical significance at C4 in both groups (median cumulative frequency of the 10 most expanded T cell clonotypes/sample in responders: 31.6% pre-treatment vs 43% C4 post-treatment, p=0.009; and, in non-responders: 19.8% pre-treatment vs 39.6% C4 post-treatment, p=0.009). In both groups, the clonotype repertoire appeared to be renewed. Interestingly, in the responders' group a significant shift was noticed in the major clonotype repertoire at screening vs C4. In particular, the 10 most expanded clonotypes/sample at C4 represented expansions of clonotypes present at very low frequency at screening, whereas the most expanded clonotypes at screening decreased or even diminished post-treatment. Additionally, although the major post-treatment clonotype at C4 also dominated at C7 in most cases, certain lower frequency clonotypes at C4 emerged among the top-10 at C7. Thirteen shared clonotypes were identified amongst the post-treatment repertoires of different patients but not in other entities in public databases, raising the possibility that they may be "MM-specific" and selected by common MM-associated antigens. Finally, flow cytometry analysis revealed a significant increase post treatment in the percentage of CD3+ T cells (median frequency at SCR 63% vs 78.7% at C4 | p=0.0045 and 87.4% at C7 | p=0.0009), driven mostly by the expansion of the CD8+ T cell compartment (median frequency at SCR 31.4% vs 45.3% at C4 | p=0.0045 and 53.8% at C7 | p=0.001) in both groups. In conclusion, we document T cell clonal expansions and clonal drift after daratumumab treatment in MM. Our results suggest that daratumumab acts through renewing the greatest part of the pre-treatment TR clonotype repertoire, suggesting dynamic changes of the T cell compartment under treatment, a claim also supported by the significant increase in CD8+ cytotoxic T cell numbers overtime. The significant post-treatment expansion of certain low-frequency pre-treatment clones in responders raises the intriguing hypothesis that daratumumab treatment may have led to the outgrowth of anti-MM T cell clones, arguably contributing to clinical response. Disclosures Kastritis: Amgen: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria, Research Funding; Genesis Pharma: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria. Hatjiharissi:Abbvie: Honoraria; Gilead: Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Genesis pharma SA: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Roche: Honoraria. Katodritou:Theagenion Cancer Hospital: Current Employment; Takeda: Honoraria, Other: Expenses, Research Funding; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Genesis Pharma: Honoraria, Other: Expenses, Research Funding; Abbvie: Research Funding; Karyopharm: Research Funding; Janssen-Cilag: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Gavriatopoulou:Amgen: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; Genesis Pharma: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria. Delimpasi:GENESIS: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Amgen: Consultancy, Honoraria. Symeonidis:Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Sanofi/Genzyme: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Honoraria, Research Funding; Astellas: Research Funding; Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; GenesisPharma: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Merck Sharp & Dohme: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; WinMedica: Research Funding. Stamatopoulos:AstraZeneca: Honoraria; Janssen, Gilead, Abbvie: Honoraria, Research Funding. Dimopoulos:Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Personal fees, Speakers Bureau; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Personal fees, Research Funding, Speakers Bureau; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Personal fees, Research Funding, Speakers Bureau; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Personal fees; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Personal fees, Research Funding, Speakers Bureau. Terpos:Amgen: Honoraria, Research Funding; Genesis pharma SA: Honoraria, Other: travel expenses , Research Funding; Janssen: Honoraria, Research Funding; Takeda: Honoraria, Other: travel expenses , Research Funding; Celgene: Honoraria; Sanofi: Honoraria; BMS: Honoraria. Chatzidimitriou:Janssen: Research Funding.

This paper attempts to analyse the perceptions of Specialist officers (Agriculture) towards Agriculture credit in public and private sector banks in Tamil Nadu. Among different zones in Tamil Nadu, Coimbatore zone was selected purposively for this study, because of its representation of maximum number of branches and credit activities. Purposive sampling of 150 Specialist officers (Agriculture) from various public sector banks and 51 Specialist officers (Agriculture) from private sector banks were selected for this study. In case of crop loan, about 91.35 per cent of Specialist Officers (Agriculture) from Public sector banks were satisfied with the disbursement of credit based on scale of finance as against 78.42 per cent in case of Private sector banks. About 70.27 per cent of Specialist Officers (Agriculture) from Public sector banks faced lot of hardships to recover agricultural loans. 84.96 per cent of Specialist Officer (Agriculture) employed from Public sector banks perceived that farmers never responded to bank notice and phone calls in case of Special Mentioned Accounts (SMA) and Non Performing Assets (NPA). However, 71.86 per cent of Specialist Officers (Agriculture) employed in Private sector banks perceived that farmers never responded to bank notice and phone calls in case of SMA and NPA. Thus from the above study, following policy implications may be arrived (i.e) Up-gradation of land records and delivery of documents through online and documentation of loan process such as mortgage, issuing of non-encumbrance certificate and verification of patta land can be published through online

Dominant understandings of genre-as-form have limited our abilities to perceive health awareness: we recognise, and expect, health awareness campaigns from governmental and non-profit agencies. Inversely, we often fail to recognise, or name, health awareness as such when it comes from other sources, such as commercial marketing or advertisements for products. However, rhetorical genre theory centres attention on action brought about by form and, as such, rhetorical genre provides tools for recognising instances of health awareness often escape our notice. One such example is critical-illness insurance marketing. In this article, I argue that critical-illness insurance marketing draws on the same appeals found in cancer awareness campaigns. Through a comparative analysis, I show that Colorectal Cancer Canada and critical-illness insurance marketing represent unpreparedness, rather than cancer, as the exigence, or the problem to be overcome through public discourse, and as such, share a genre of what I call ‘health awareness as preparedness’.

Drawing upon popular magazines, newspapers, blogs, Web sites, and videos, this essay compares the media framing of six, “fat” political figures from around the world. Framing refers to the suggested interpretations that are imbedded in media reports (Entman; McCombs and Ghanem; Seo, Dillard and Shen). As Robert Entman explains, framing is the process of culling a few elements of perceived reality and assembling a narrative that highlights connections among them to promote a particular interpretation. Frames introduce or raise the salience of certain ideas. Fully developed frames typically perform several functions, such as problem definition and moral judgment. Framing is connected to the [covert] wielding of power as, for example, when a particular frame is intentionally applied to obscure other frames. This comparative international study is an inquiry into “what people and societies make of the reality of [human weight]” (Marilyn Wann as quoted in Rothblum 3), especially in the political arena. The cultural and historical dimensions of human weight are illustrated by the practice of force-feeding girls and young women in Mauritania, because “fat” women have higher status and are more sought after as brides (Frenkiel). The current study, however, focuses on “fat” politics. The research questions that guide the study are: [RQ1] which terms do commentators utilize to describe political figures as “fat”? [RQ2] Why is the term “fat” utilized in the political arena? [RQ3] To what extent can one detect gender, national, or other differences in the manner in which the term “fat” is used in the political arena? After a brief introduction to the current media obsession with fat, the analysis begins in 1908 with William Howard Taft, the 330 pound, twenty-seventh President of the United States. The other political figures are: Chris Christie (Governor of New Jersey), Bill Clinton (forty-second President of the United States), Michelle Obama (current First Lady of the United States), Carla Bruni (former First Lady of France), and Julia Gillard (former Prime Minister of Australia). The final section presents some conclusions that may help readers and viewers to take a more critical perspective on “fat politics.” All of the individuals selected for this study are powerful, rich, and privileged. What may be notable is that their experiences of fat shaming by the media are different. This study explores those differences, while suggesting that, in some cases, their weight and appearance are being attacked to undercut their legitimate and referent power (Gaski). Media Obsession with Fat “Fat,” or “obesity,” the more scientific term that reflects the medicalisation of “fat” (Sobal) and which seems to hold sway today, is a topic with which the media currently is obsessed, both in Asia and in the United States. A quick Google search using the word “obesity” reports over 73 million hits. Ambady Ramachandran and Chamukuttan Snehalatha report on “The Rising Burden of Obesity in Asia” in a journal article that emphasizes the term “burden.” The word “epidemic” is featured prominently in a 2013 medical news report. According to the latter, obesity among men was at 13.8 per cent in Mongolia and 19.3 per cent in Australia, while the overall obesity rate has increased 46 per cent in Japan and has quadrupled in China (“Rising Epidemic”). Both articles use the word “rising” in their titles, a fear-laden term that suggests a worsening condition. In the United States, obesity also is portrayed as an “epidemic.” While some progress is being made, the obesity rate nonetheless increased in sixteen states in 2013, with Louisiana at 34.7 per cent as the highest. “Extreme obesity” in the United States has grown dramatically over thirty years to 6.3 per cent. The framing of obesity as a health/medical issue has made obesity more likely to reinforce social stereotypes (Saguy and Riley). In addition, the “thematic framing” (Shugart) of obesity as a moral failure means that “obesity” is a useful tool for undermining political figures who are fat. While the media pay considerable attention to the psychological impact of obesity, such as in “fat shaming,” the media, ironically, participate in fat shaming. Shame is defined as an emotional “consequence of the evaluation of failure” and often is induced by critics who attack the person and not the behavior (Boudewyns, Turner and Paquin). However, in a backlash against fat shaming, “Who you callin' fat?” is now a popular byline in articles and in YouTube videos (Reagan). Nevertheless, the dynamics of fat are even more complicated than an attack-and-response model can capture. For example, in an odd instance of how women cannot win, Rachel Frederickson, the recent winner of the TV competition The Biggest Loser, was attacked for being “too thin” (Ceja and Valine). Framing fat, therefore, is a complex process. Fat shaming is only one way that the media frame fat. However, fat shaming does not appear to be a major factor in media coverage of William Howard Taft, the first person in this study. William Howard Taft William Howard Taft was elected the 27th President of the United States in 1908 and served 1909-1913. Whitehouse.com describes Taft as “Large, jovial, conscientious…” Indeed, comments on the happy way that he carried his “large” size (330 pounds) are the main focus here. This ‹happy fat› framing is much different than the media framing associated with ‹fat shaming›. His happy personality was often mentioned, as can be seen in his 1930 obituary in The New York Times: “Mr. Taft was often called the most human President who ever sat in the White House. The mantle of office did not hide his winning personality in any way” (“Taft Gained Peaks”). Notice how “large” and “jovial” are combined in the framing of Taft. Despite his size, Taft was known to be a good dancer (Bromley 129). Two other words associated with Taft are “rotund” (round, plump, chubby) and “pudgy.” These terms seem a bit old-fashioned in 2015. “Rotund” comes from the Latin for “round,” “circular,” “spherical.” “Pudgy,” a somewhat newer term, comes from the colloquial for “short and thick” (Etymology Online). Taft was comfortable with being called “pudgy.” A story about Taft’s portrait in the Smithsonian’s National Portrait Gallery in Washington, D.C. illustrates the point: Artist William Schevill was a longtime acquaintance of Taft and painted him several times between 1905 and 1910. Friendship did not keep Taft from criticizing the artist, and on one occasion he asked Schevill to rework a portrait. On one point, however, the rotund Taft never interfered. When someone said that he should not tolerate Schevill's making him look so pudgy in his likenesses, he simply answered, "But I am pudgy." (Kain) Taft’s self-acceptance, as seen in the portrait by Schevill (circa 1910), stands in contrast to the discomfort caused by media framing of other fat political figures in the era of more intense media scrutiny. Chris Christie Governor Christie has tried to be comfortable with his size (300+ pounds), but may have succumbed to the medicalisation of fat and the less than positive framing of his appearance. As Christie took the national stage in the aftermath of Hurricane Sandy (2012), and subsequently explored running for President, he may have felt pressure to look more “healthy” and “attractive.” Even while scoring political points for his leadership in the aftermath of Superstorm Sandy, Christie’s large size was apparent. Filmed in his blue Governor jacket during an ABC TV News report that can be accessed as a YouTube video, Christie obviously was much larger than the four other persons on the speakers’ platform (“Jersey Shore Devastated”). In the current media climate, being known for your weight may be a political liability. A 2015 Rutgers’ Eagleton Poll found that 53 percent of respondents said that Governor Christie did not have “the right look” to be President (Capehart). While fat traditionally has been associated with laziness, it now is associated with health issues, too. The media framing of fat as ‹morbidly obese› may have been one factor that led Christie to undergo weight loss surgery in 2013. After the surgery, he reportedly lost a significant amount of weight. Yet his new look was partially tarnished by media reports on the specifics of lap-band-surgery. One report in The New York Daily News stressed that the surgery is not for everyone, and that it still requires much work on the part of the patient before any long-term weight loss can be achieved (Engel). Bill Clinton Never as heavy as Governor Christie, Bill Clinton nonetheless received considerable media fat-attention of two sorts. First, he could be portrayed as a kind of ‹happy fat “Bubba”› who enjoyed eating high cholesterol fast food. Because of his charm and rhetorical ability (linked to the political necessity of appearing to understand the “average person”), Clinton could make political headway by emphasizing his Arkansas roots and eating a hamburger. This vision of Bill Clinton as a redneck, fast-food devouring “Bubba” was spoofed in a popular 1992 Saturday Night Live skit (“President-Elect Bill Clinton Stops by a McDonald's”). In 2004, after his quadruple bypass surgery, the media adopted another way to frame Bill Clinton. Clinton became the poster-child for coronary heart disease. Soon he would be framed as the ‹transformed Bubba›, who now consumed a healthier diet. ‹Bill Clinton-as-vegan› framing fit nicely with the national emphasis on nutrition, including the widespread advocacy for a largely plant-based diet (see film Forks over Knives). Michelle Obama Another political figure in the United States, whom the media has connected both to fast food and healthy nutrition, is Michelle Obama. Now in her second term as First Lady, Michelle Obama is associated with the national campaign for healthier school lunches. At the same time, critics call her “fat” and a “hypocrite.” A harsh diatribe against Obama was revealed by Media Matters for America in the personal attacks on Michelle Obama as “too fat” to be a credible source on nutrition. Dr. Keith Ablow, a FOX News medical adviser said, Michelle Obama needs to “drop a few” [pounds]. “Who is she to be giving nutrition advice?” Another biting attack on Obama can be seen in a mocking 2011 Breitbart cartoon that portrayed Michelle Obama devouring hamburgers while saying, “Please pass the bacon” (Hahn). Even though these attacks come from conservative media utterly opposed to the presidency of Barack Obama, they nonetheless reflect a more widespread political use of media framing. In the case of Michelle Obama, the media sometimes cannot decide if she is “statuesque” or “fat.” She is reported to be 5’11 tall, but her overall appearance has been described as “toned” (in her trademark sleeveless dresses) yet never as “thin.” The media’s ambivalence toward tall/large women is evident in the recent online arguments over whether Robyn Lawley, named one of the “rookies of the year” by the Sports Illustrated Swimsuit issue, has a “normal” body or a “plus-size” body (Blair). Therefore, we have two forms of media framing in the case of Michelle Obama. First, there is the ‹fat hypocrite› frame, an ad hominem framing that she should not be a spokesperson for nutrition. This first form of framing, perhaps, is linked to the traditional tendency to tear down political figures, to take them off their pedestals. The second form of media framing is a ‹large woman ambiguity› frame. If you are big and tall, are you “fat”? Carla Bruni Carla Bruni, a model and singer/songwriter, was married in 2008 to French President Nicolas Sarkozy (who served 2007 to 2012). In 2011, Bruni gave birth to a daughter, Giulia. After 2011, Bruni reports many attacks on her as being too “fat” (Kim; Strang). Her case is quite interesting, because it goes beyond ‹fat shaming› to illustrate two themes not previously discussed. First, the attacks on Bruni seem to connect age and fat. Specifically, Bruni’s narrative introduces the frame: ‹weight loss is difficult after giving birth›. Motherhood is taxing enough, but it becomes even more difficulty when the media are watching your waist line. It is implied that older mothers should receive more sympathy. The second frame represents an odd form of reverse fat shaming: ‹I am so sick and tired of skinny people saying they are fat›. As Bruni explains: “I’m kind of tall, with good-size shoulders, and when I am 40 pounds overweight, I don’t even look fat—I just look ugly” (Orth). Critics charge that celebs like Bruni not only do not look fat, they are not fat. Moreover, celebs are misguided in trying to cultivate sympathy that is needed by people who actually are fat. Several blogs echo this sentiment. The site Whisper displays a poster that states: “I am so sick and tired of skinny people saying they are fat.” According to Anarie in another blog, the comment, “I’m fat, too,” is misplaced but may be offered as a form of “sisterhood.” One of the best examples of the strong reaction to celebs’ fat claims is the case of actress Jennifer Lawrence. According The Gloss, Lawrence isn’t chubby. She isn’t ugly. She fits the very narrow parameters for what we consider beautiful, and has been rewarded significantly for it. There’s something a bit tone deaf in pretending not to have thin or attractive privilege when you’re one of the most successful actresses in Hollywood, consistently lauded for your looks. (Sonenshein) In sum, the attempt to make political gain out of “I’m fat” comments, may backfire and lead to a loss in political capital. Julia Gillard The final political figure in this study is Julia Eileen Gillard. She is described on Wikipedia as“…a former Australian politician who served as the 27th Prime Minister of Australia, and the Australian Labor Party leader from 2010 to 2013. She was the first woman to hold either position” (“Julia Gillard”). Gillard’s case provides a useful example of how the media can frame feminism and fat in almost opposite manners. The first version of framing, ‹woman inappropriately attacks fat men›, is set forth in a flashback video on YouTube. Political enemies of Gillard posted the video of Gillard attacking fat male politicians. The video clip includes the technique of having Gillard mouth and repeat over and over again the phrase, “fat men”…”fat men”…”fat men” (“Gillard Attacks”). The effect is to make Gillard look arrogant, insensitive, and shrill. The not-so-subtle message is that a woman should not call men fat, because a woman would not want men to call her fat. The second version of framing in the Gillard case, ironically, has a feminist leader calling Gillard “fat” on a popular Australian TV show. Australian-born Germaine Greer, iconic feminist activist and author of The Female Eunuch (1970 international best seller), commented that Gillard wore ill-fitting jackets and that “You’ve got a big arse, Julia” (“You’ve Got”). Greer’s remarks surprised and disappointed many commentators. The Melbourne Herald Sun offered the opinion that Greer has “big mouth” (“Germaine Greer’s”). The Gillard case seems to support the theory that female politicians may have a more difficult time navigating weight and appearance than male politicians. An experimental study by Beth Miller and Jennifer Lundgren suggests “weight bias exists for obese female political candidates, but that large body size may be an asset for male candidates” (p. 712). Conclusion This study has at least partially answered the original research questions. [RQ1] Which terms do commentators utilize to describe political figures as “fat”? The terms include: fat, fat arse, fat f***, large, heavy, obese, plus size, pudgy, and rotund. The media frames include: ‹happy fat›, ‹fat shaming›, ‹morbidly obese›, ‹happy fat “Bubba›, ‹transformed “Bubba›, ‹fat hypocrite›, ‹large woman ambiguity›, ‹weight gain women may experience after giving birth›, ‹I am so sick and tired of skinny people saying they are fat›, ‹woman inappropriately attacks fat men›, and ‹feminist inappropriately attacks fat woman›. [RQ2] Why is the term “fat” utilized in the political arena? Opponents in attack mode, to discredit a political figure, often use the term “fat”. It can imply that the person is “unhealthy” or has a character flaw. In the attack mode, critics can use “fat” as a tool to minimize a political figure’s legitimate and referent power. [RQ3] To what extent can one detect gender, national, or other differences in the manner in which the term “fat” is used in the political arena? In the United States, “obesity” is the dominant term, and is associated with the medicalisation of fat. Obesity is linked to health concerns, such as coronary heart disease. Weight bias and fat shaming seem to have a disproportionate impact on women. This study also has left many unanswered questions. Future research might fruitfully explore more of the international and intercultural differences in fat framing, as well as the differences between the fat shaming of elites and the fat shaming of so-called ordinary citizens.References Anarie. “Sick and Tired.” 7 July 2013. 17 May 2015 ‹http://www.sparkpeople.com/ma/sick-of--thin-people-saying-they-are-fat!/1/1/31404459›. Blair, Kevin. “Rookie Robyn Lawley Is the First Plus-Size Model to Be Featured in the Sports Illustrated Swimsuit Issue.” 6 Feb. 2015. 22 Apr. 2015 ‹http://www.starpulse.com/news/Kevin_Blair/2015/02/06/rookie-robin-lawley-is-the-first-pluss›. Boudewyns, Vanessa, Monique Turner, and Ryan Paquin. “Shame-Free Guilt Appeals.” Psychology & Marketing 23 July 2013. doi: 10.1002/mar.20647. Bromley, Michael L. William Howard Taft and the First Motoring Presidency. Jefferson, NC: McFarland & Company, 2007. Capehart, Jonathan. “Chris Christie’s Dirty Image Problem.” 18 Feb. 2015. 22 Apr. 2015 ‹http://www.washingtonpost.com/blogs/post-partisan/wp/2015/02/18/chris-christies-dirty-image-problem/›.“Carla Bruni.” n.d. 22 Apr. 2015 ‹http://www.biography.com/people/carla-bruni-17183782›. Ceja, Berenice, and Karissa Valine. “Women Can’t Win: Gender Irony and the E-Politics of Food in The Biggest Loser.” Unpublished manuscript. Humboldt State University, 2015. “Chris Christie to Consider.” 17 April 2012. 22 Apr. 2015 ‹http://www.seeyounexttuesday.com-468›. Conason, Joe. “Bill Clinton Explains Why He Became a Vegan.” AARP The Magazine, Aug./Sep. 2013. 22 Apr. 2015 ‹http://www.aarp.org/health/healthy-living/info-08-2013/bill-clinton-vegan.html›. Engel, Meredith. “Lap Band Surgery.” New York Daily News. 24 Sep. 2014. 22 Apr. 2015 ‹http://www.nydailynews.com/life-style/health/lap-band-surgery-helped-chris-christie-article-1.1951266›. Entman, Robert M. “Framing Bias: Media in the Distribution of Power.” Journal of Communication 57 (2007): 163-173. Etymology Online. n.d. 22 Apr. 2015 ‹http://etymonline.com/›. Frenkiel, Olenka. “Forced to Be Fat.” The Sunday Mail (Queensland, Australia). 13 Nov. 2005: 64. Gaski, John. “Interrelations among a Channel Entity's Power Sources: Impact of the Expert, Referent, and Legitimate Power Sources.” Journal of Marketing Research 23 (Feb. 1986): 62-77. Hahn, Laura. “Irony and Food Politics.” Communication and Critical/Cultural Studies 12 Feb. 2015. doi: 10.1080/14791420.2015.1014185.“Julia Gillard.” n.d. 22 Apr. 2015 ‹http://en.wikipedia.org/wiki/Julia_Gillard›. Kain, Erik. “A History of Fat Presidents.” Forbes.com 28 Sep. 2011. 22 Apr. 2015 ‹http://www.forbes.com/sites/erikkain/2011/09/28/a-history-of-fat-presidents/›.Kim, Eun Kyung. “Carla Bruni on Media: They Get Really Nasty.” 22 Apr. 2015 ‹http://www.today.com/news/carla-bruni-media-they-get-really-nasty-6C9733510›. McCombs, Max, and S.I. Ghanem. “The Convergence of Agenda Setting and Framing.” In Stephen D. Reese, Oscar. H. Gandy, Jr., and August Grant (eds.), Framing Public Life: Perspectives on Media and Our Understanding of the Social World. Mahwah, NJ: Erlbaum, 2001. 67-83. Miller, Beth, and Jennifer Lundgren. “An Experimental Study on the Role of Weight Bias in Candidate Evaluation.” Obesity 18 (Apr. 2010): 712-718. Orth, Maureen. “Carla on a Hot Tin Roof.” Vanity Fair June 2013. 22 Apr. 2015 ‹http://www.vanityfair.com/hollywood/2013/06/carla-bruni-musical-career-album›. “President-Elect Bill Clinton Stops by a McDonalds.” n.d. 22 Apr. 2015 ‹https://screen.yahoo.com/clinton-mcdonalds-000000491.html›. Ramachandran, Ambady, and Chamukuttan Snehalatha. “The Rising Burden of Obesity in Asia.” Journal of Obesity (2010). doi: 10.1155/2010868573. 22 Apr. 2015 ‹http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939400/›.Reagan, Gillian. “Ex-Chubettes Unite! Former Fat Kids Let It All Out.” New York Observer 22 Apr. 2008. 22 Apr. 2015 ‹http://observer.com/2008/04/exchubettes-unite-former-fat-kids-let-it-all-out/›. “Rising Epidemic of Obesity in Asia.” News Medical 21 Feb. 2013. 23 Apr. 2015 ‹http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939400/›. Rothblum, Esther. “Why a Journal on Fat Studies?” Fat Studies 1 (2012): 3-5. Saguy, Abigail C., and Kevin W. Riley. “Weighing Both Sides: Morality, Mortality, and Framing Contests over Obesity.” Journal of Health Politics, Policy and Law 30.5 (2005): 869-921. Seo, Kiwon, James P. Dillard, and Fuyuan Shen. “The Effects of Message Framing and Visual Image on Persuasion. Communication Quarterly 61 (2013): 564-583. Shugart, Helene A. “Heavy Viewing: Emergent Frames in Contemporary News Coverage of Obesity.” Health Communication 26 (Oct./Nov. 2011): 635-648. Sobal, Jeffery. “The Medicalization and Demedicalization of Obesity.” Eating Agendas: Food and Nutrition as Social Problems. Ed. Jeffery Sobal and Donna Maurer. New York: Aldine de Gruyter, 1995. 67-90. Sonenshein, Julia. “Jennifer Lawrence Does More Harm than Good with Her ‘I’m Chubby’ Comments.” 3 Jan. 2014. 16 May 2015 ‹http://www.thegloss.com/2014/01/03/culture/jennifer-lawrence-fat-comments-body-image/#ixzz3aWTEg35U›. Strang, Fay. ”Carla Bruni Admits Used Therapy.” 3 May 2013. 22 Apr. 2015 ‹http://www.dailymail.co.uk/tvshowbiz/article-2318719/Carla-Bruni-admits-used-therapy-deal-comments-fat-giving-birth-forties.html›. “Taft Gained Peaks in Unusual Career.” The New York Times 9 March 1930. 22 Apr. 2015 ‹http://www.nytimes.com/learning/general/onthisday/bday/0915.html›. Vedantam, Shankar. “Clinton's Heart Bypass Surgery Called a Success.” Washington Post 7 Sep. 2004: A01. “William Howard Taft.” Whitehouse.com. n.d. 12 May 2015. Whisper. n.d. 16 May 2015 ‹https://sh.whisper/o5o8bf3810d45295605bce53f8082Db6ddb29/I-am-so-sick-and-tired-of-skinny-people-saying-that-they-are-fat›. “You’ve Got a Big Arse, Julia. Germaine Greer Advice for Julia Gillard.” Politics and Porn in a Post-Feminist World. 24 Aug. 2012. 22 Apr. 2015 ‹https://www.youtube.com/watch?v=8lFtww!D3ss›. See also: ‹http://www.smh.com.au/federal-politics/political-news/greer-defends-fat-arse-pm-comment-20120827-24x5i.html›.

Introduction: Two findings can be highlighted from recent medical research, first children of a young age are involved in organized sports activities more frequently than ever and second the first symptoms of Osgood-Schlatter disease (OSD) have been reported in children at the age of 5.5 years. The latest research has shown that children from ages 10 to 12 years have already been actively involved in sports activities for 5–7 years. In recent years, the practice of young children training to master sports has become a trend. Said exposes young children who are training intensively to various external risk factors such as social isolation, addiction, frequent injuries, and syndrome of overload. Enablers of this behavior are commonly parents and coaches who notice the child’s abilities stand out from those of other children in the group and find that such talent requires intensive sport-specific training. The purpose of this study was to determine the average age of the patients and the average age when the first symptoms of the disease appeared as well as to provide an analysis of the average duration of children being actively involved in sports activities before the first symptoms of OSD appeared. Methods: The research has been conducted on 200 patients who were previously diagnosed with Osgood-Schlatter’s syndrome. The participants were divided into two groups each containing 100 patients, first group –aerobic sports (football and basketball) and the second group –anaerobic sports (karate and taekwondo). Personal information, anthropometric measurements, complete medical, and sports history were taken from the patients. A clinical examination was conducted by the researcher himself. The study was prospective, clinical, comparative, analytical, and descriptive. The research was conducted in Public Center for Sports Medicine of Canton Sarajevo. Software used for statistical data analysis was SPSS for Windows (version 20.0, SPSS Inc., Chicago, Illinois, USA) and Microsoft Excel (version 13 of Microsoft Corporation, Redmond, WA, USA). Results: The average age when the patients started with intensive training was highest with basketball players (7.8 years) following with karate trainees (6.8 years). Basketball players had statistically the lowest duration of being actively involved in sports activities before the first symptoms of OSD appeared (5.4 years). No statistically significant difference in the average duration of training was discovered between the test groups. The average age when knee pain or swelling under the knee first appeared was at the age of 11.4 years with players of aerobic sports and 11.8 years with players of anaerobic sports. Furthermore, no statistically significant difference was found between test groups and subgroups. Before the first appearance of knee pain, the taekwondo patients had been in training the longest (4.7 years) and basketball players the least amount of time (3.4 years). Conclusion: By conducting retrospective analysis, it has been concluded that children had started training at the age of 3 or 4 years and had encountered the first symptoms of OSD at the ages of 4 years (football) and 6 years (taekwondo). Research showed that the early involvement of children in sports and their early specialization in sports are both external risk factors that have a dominant influence on OSD development.

Aim: With over 60 million recorded cases, and the death of 2 million the world is indeed struggling with a serious public health threat, coronavirus. Lack of health awareness and directive particularly for children. Health care providers and parents are seriously worried for children as this is an unknown disease with no evidence-based to build up a sound clinical decision. Being restricted to a limited zone and ordered to a tightened precautions and safety roles are gated your psychological burden, multiple neuropsychiatric indices, and psychosocial stigma. School and active life is an essential part of the children's lifetime, while temporary school closures as a result of health crises are not only affecting the educational achievement but most importantly the physical -mental, and social aspects. The home detention for children is indeed upsetting and anticipated to have detrimental crucial effects on children’s physical and mental capacity and shatter the sense of growth normalcy that schools used to provide. The aim is to study the impact of Covid-19 quarantine consequences on psychosocial on Saudi children. Method: A cross-sectional, analytical, comparative study using an anonymous electronic survey to the general population aged 3-15 years was done in which it showed parents-reported changes in the reaction, behaviors, and attitudes of their children related to psychosocial status during the Covid-19 lockdown. Result: The behavior changes were noticed in the isolation, aggressiveness, physical activity, and reaction to learning. Families were noticed an attitude, behavior and psychological signs in almost 52, 58.57% respectively of their children. The family long-term impact expectations are negative in almost 40% of the population. Conclusion: Almost 40-45% of the population showed the abnormal psychosocial impact of the Covid19 Quarantine consequences. The expected long-term impact may reach more than 40%. Estimates incidence in normal circumstances was 2-3% to 22%.

Aims: The contamination of sea fish and seafood by bacteria of fecal origin along with various pathogenic drug-resistant microorganisms are widely documented as the cause of several human diseases. Our present studies aim to determine the comparative microbiological quality among raw, cooked and cooked-frozen fish along with antimicrobial profiling of those isolated pathogenic and non-pathogenic microbes with potential drug modelling and increasing the awareness of taking unnecessary antibiotics. The objective of the present study was to investigate the status of fish in cold condition after cooking. Methodology: We collected a total of four sea fish species (Rupchada, Koral, Tuna, and Poma) from the local shops in Dhaka city. Raw, cooked, and frozen fish samples were analyzed for the existence of pathogenic bacteria through conventional cultural techniques and the confirmatory biochemical identification procedures. Kirby-Bauer disk diffusion method was performed to demonstrate the antibiotic susceptibility pattern of isolated microorganisms. Results: Total viable bacteria were present in all four fish samples in raw, cooked, and frozen condition up to 8.5 log CFU/ml. Most of the raw fish samples were found to harbour a vast population of microorganisms up to 7 log CFU/ml, including fecal coliforms. Several specific bacterial species like Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Staphylococcus spp., Pseudomonas spp. and Vibrio spp. were noticed to be present in raw samples. The microbial loads were reduced in cooked samples, and the status was static in frozen samples. The study of antibiogram showed several pathogenic isolates to be drug-resistant against second-line drugs. Conclusion: Thus, the incidence of fecal coliforms in raw fish may be considered as a severe threat to public health upon consumption of such fishes. Such a prevalence of pathogens in the studied fish samples, including antibiotic-resistant strains of pathogenic microorganisms, can lead to severe public health risk and are the significant findings of this study.

Abstract Background Stroke is a health problem with serious consequences, both in terms of mortality, and after-effects affecting patient quality of life. Stroke requires both urgent and chronic management involving the entire health care system. Although large variability in the management of stroke patients have been noticed, knowledge of the diversity and the scalability of post-stroke pathways, whether it is the care pathway or the life pathway, is currently not sufficient. Moreover the link between post-stroke pathways and patients sequelae have not been yet clearly defined. All this information would be useful to better target the needs to improve stroke patient management. The purposes are to identify the post-stroke life pathways components associated with sequelae (activity limitations – main purpose, cognitive disorders, anxio-depressive disorders, fatigue, participation restrictions) at 3 months and 1 year post-stroke, to define a typology of life pathways of patients during the post-stroke year and to analyze the social and geographical inequalities in the management of stroke. Methods Design: a prospective multicenter comparative cohort study with a follow up to 1 year after the acute episode. Participant centers: 13 hospitals in the Aquitaine region (France). Study population: patients diagnosed with a confirmed ischemic or hemorrhagic stroke included in the Aquitaine Observatory of Stroke (ObA2) cohort and voluntary to participate. Data sources are existing databases (ObA2 database and the French National Health Data System - SNDS) to collect information about care pathways, patient characteristics and stroke characteristics and Ad hoc surveys to collect information about life pathways and post-stroke sequelae. The endpoints of the study are post-stroke activity limitations evaluated by the modified Rankin score, other post-stroke sequelae (Cognitive disorders, anxio-depressive disorders, fatigue, restriction of participation) assessed by standardized and validated scales and Clusters of patients responding to pathways with common or similar characteristics.; Discussion By integrating a longitudinal dimension and relying on a large cohort, the project will make it possible to identify the sources of disturbances and the factors favorable to the outcome of the life pathways, important for the planning of the offer and the management of the public policies concerning stroke pathways. Trial registration ClinicalTrials.gov ID: NCT03865173, March 6th, 2019.

ABSTRACT Citrus canker, caused by Xanthomonas citri pv. citri, is a serious disease of citrus plants worldwide. Earlier phylogenetic studies using housekeeping genes revealed that X. citri pv. citri is related to many other pathovars, which can be collectively referred as Xanthomonas citri pathovars (XCPs). From the present study, we report the genome sequences of 18 XCPs and compared them with four XCPs available in the public domain. In a tree based on phylogenomic marker genes, all the XCPs form a monophyletic cluster, suggesting their origin from a common ancestor. Phylogenomic analysis using the type strain further established that all the XCPs belong to one species. Clonal analysis of the core genome revealed the presence of two major lineages within this monophyletic cluster consisting of some clonal variants. Incidentally, the majority of these XCPs were first noticed in India, corroborating their clonal relationship and their common origin. Comparative analysis revealed an open pan-genome and the role of interstrain genomic flux of these XCPs since their diversification from a common ancestor. Even though there are wide variations in type III gene effectomes, we identified three core effectors which can be valuable in resistance-breeding programs. Overall, genomic examination of ecological relatives allowed us to dissect the tremendous genomic potential of X. citri species to rapidly evolve into specialized strains infecting diverse crop plants. IMPORTANCE Host specialization is one of the characteristic features of highly evolved pathogens such as the Xanthomonas group of phytopathogenic bacteria. Since the hosts involve staple crops and economically important fruits such as citrus, detailed understanding of the diversity and evolution of such strains infecting diverse plants is important for quarantine purposes. In the present study, we carried out genomic investigation of members of a phylogenetically and ecologically defined group of Xanthomonas strains pathogenic to diverse plants, including citrus. This group includes the oldest Xanthomonas pathovars and also recently emerged pathovars in a particular country where they are endemic. Our high-throughput genomic study has provided novel insights into the evolution of a unique lineage consisting of serious pathogens and their ecological relatives, suggesting the nature, scope, and pattern of rapid and recent diversification. Further, from the level of species to that of clonal variants, the study revealed interesting genomic patterns in diversification of a Xanthomonas lineage and perhaps will inspire careful study of the host range of the included pathovars.

In 2020, the rapid spread of Covid-19, a disease caused by a highly contagious virus, led many governments to adopt measures of social distancing, including the suspension of activities considered non-essential and the closure of public spaces. In Brazil, a country that is distinguished by sun, sea and sand tourism (3s), the effects were immediate in the months of March, April, May and June: closed beaches and the suspension of all economic activities linked to it. This article seeks to understand the effects of the Covid-19 pandemic on a traditional sector of the beach economy in Rio de Janeiro, the “tent business”. For that, we analyzed: 1) the organization of this sector in the pre-pandemic period; 2) the legal measures adopted to contain the spread of the new coronavirus and which affected the uses of beaches; 3) the effects of the pandemic on the daily lives of beach workers 4) the challenges for the resumption of activities in the post-pandemic period. The data used in this research are the result of surveys and fieldwork carried out in the period before the pandemic and the application, during quarantine, of semi-structured interviews, via social networks, with owners and employees of tents on the beaches of the city’s waterfront. For this study, the normative measures that affected the beaches of the city of Rio de Janeiro during the pandemic were also analyzed. As main results, we highlight, first, the importance of the “tent business” in the economic circuits associated with Rio beaches, as well as the role that tents play as poles of concentration of bathers in the sand strip. Regarding governmental measures of social distance, we noticed that the beaches were one of the areas affected for the longest time by the suspension of activities and that, until the total reopening occurred in October, the activities associated with the solarium, such as the “tent business”, were those that presented a more uncertain horizon of recovery. The impacts on the daily lives of the owners of the tents and their employees were enormous, with the vertiginous decrease of their incomes and the difficulties of finding alternative occupations. These effects were partially offset by the adoption of assistance measures by governments and the creation of support networks involving beachgoers, both Brazilian and foreigner, as a result of a relationship built over the years with stallholders and other beach workers. Finally, from a comparative exercise with other situations in the world, we highlight the challenges that are already being faced for the adoption of new ways of ordering the uses of beaches in the post-pandemic world. Keywords: Coastal management, social distancing, beach workers, beachfront, solarium.

Abstract Resources currently available to the scientific community that may be of interest for endocrinology research are described briefly here. More information is available through The Endocrine Society Home Page (http://www.endo-society.org) or the information provided below. HUMAN TISSUE RESOURCES NCI - Cooperative Human Tissue Network (CHTN) The NCI Cooperative Human Tissue Network (CHTN) provides normal, benign, precancerous, and cancerous human tissue to the scientific community for biomedical research. Specimens are collected according to the investigator’s individual protocol. Information provided with the specimens includes routine histopathologic and demographic data. Contact the CHTN Web site at http://www-chtn.ims.nci.nih.gov, or 1-866-GO2-CHTN (1-866-462-2486). NCI - Cooperative Breast Cancer Tissue Resource (CBCTR) The NCI Cooperative Breast Cancer Tissue Resource (CBCTR) can provide researchers with access to over 9,000 cases of formalin-fixed, paraffin-embedded primary breast cancer specimens, with associated pathologic, clinical, and outcome data. All specimens are evaluated for pathologic diagnosis by CBCTR pathologists using standard diagnostic criteria. The collection is particularly well suited for validation studies of diagnostic and prognostic markers. Researchers can search an online database to determine whether the resource specimens and data meet their needs. Contact CBCTR’s Web site at: http://www-cbctr.ims.nci.nih.gov, or Ms. Sherrill Long, Information Management Services, Inc., (301) 984-3445; e-mail: longs@imsweb.com. NCI - Cooperative Prostate Cancer Tissue Resource (CPCTR) The NCI Cooperative Prostate Cancer Tissue Resource (CPCTR) can provide researchers with access to paraffin-embedded and frozen prostate cancer tissues with associated clinical and outcome data. The collection is particularly useful for validation studies of diagnostic and prognostic markers. Questions about the resource should be directed to ASK-CPCTR-L@LIST.NIH.GOV. Additional information can be obtained from CPCTR’s Web site at http://www.prostatetissues.org, or by contacting Ms. Sherrill Long, Information Management Services, Inc., (301) 984-3445; e-mail: longs@imsweb.com. NCI - AIDS and Cancer Specimen Resource (ACSR) The AIDS and Cancer Specimen Resource (ACSR) provides qualified researchers with tissue, cell, blood, and fluid specimens, as well as clinical data from patients with AIDS and cancer. The specimens and clinical data are available for research studies, particularly those that translate basic research findings to clinical application. Contact the ACSR Web site (http://acsr.ucsf.edu/), or Dr. Jodi Black, (301) 402-6293; e-mail: jb377x@nih.gov. NCI - Breast, Ovarian, and Colorectal Cancer Family Registries (CFRs) The Cancer Family Registries (CFRs) include two international registries: the Cancer Family Registry for Breast Cancer Studies (Breast CFR) and the Cancer Family Registry for Colorectal Cancer Studies (Colon CFR). The Breast CFR provides family history information, biological specimens, and epidemiologic and clinical data from clinic-based and population-based families at risk for breast and ovarian cancers. The Breast CFR infrastructure is particularly suited to support interdisciplinary and translational breast cancer research. Similarly, the Colon CFR collection includes family history information, epidemiologic and clinical data, and related biological specimens from individuals with colorectal cancer and their families. The colon CFR is a resource for population- and clinic-based translational research in the genetic epidemiology of colorectal cancer. For information on these registries, contact the CFR Web site (http://epi.grants.cancer.gov/cfr.html) or (301) 496-9600. NCI - Specimen Resource Locator The NCI Specimen Resource Locator (http://cancer.gov/specimens) is a database that helps researchers locate specimens for research. The database includes resources such as tissue banks and tissue procurement systems with access to normal, benign, precancerous, and/or cancerous human tissue covering a wide variety of organ sites. Researchers specify the types of specimens, number of cases, preservation methods, and associated data they require. The Locator will search the database and return a list of tissue resources most likely to meet their requirements. When no match is obtained, the researcher is referred to the NCI Tissue Expediter [(301) 496-7147; e-mail: tissexp@mail.nih.gov]. The Tissue Expediter is a scientist who can help match researchers with appropriate resources or identify appropriate collaborators when those are necessary. NIDDK - Biologic Samples from Diabetic Study Foundation A portion (1/3) of all stored nonrenewable samples (plasma, serum, urine) from subjects enrolled in the Diabetes Control and Complications Trial (DCCT) is available for use by the scientific community to address questions for which these samples may be invaluable. Announcements for using this resource appear in the NIH Guide for Grants and Contractsperiodically. Inquiries may be addressed to: Catherine C. Cowie, Ph.D., Director, Type I Diabetes Clinical Trials Program, NIDDK, 6707 Democracy Blvd., Room 691, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20814-9692. Phone: (301) 594-8804; fax: (301) 480-3503; e-mail: cowiec@extra.niddk.nih.gov. NICHD - Brain and Tissue Bank for Developmental Disorders The purpose of the Bank is to collect, preserve, and distribute human tissues to investigators interested in autism and developmental disorders; normal tissues may be available for other research purposes. Further information can be obtained at: www.btbank.org. The contact persons are H. Ron Zielke or Sally Wisniewsky, University of Maryland (1-800-847-1539), and Carol Petito or Stephanie Lojko, University of Miami (1-800-592-7246). NCRR - Human Tissues and Organs Resource (HTOR) The Human Tissues and Organs Resource (HTOR) cooperative agreement supports a procurement network developed by the National Disease Research Interchange (NDRI), a not-for-profit organization. By collaborating with various medical centers, hospitals, pathology services, eye banks, tissue banks, and organ procurement organizations, HTOR provides a wide variety of human tissues and organs—both diseased and normal—to researchers for laboratory studies. Such samples include tissues from the central nervous system and brain; cardiovascular system; endocrine system; eyes, bone, and cartilage. For further information, consult the NDRI Web site (www.ndri.com) or contact Ms. Sally Strickler at NDRI, 1880 John F. Kennedy Boulevard, 6th Floor, Philadelphia, PA 19103. Phone: (800) 222-6374, ext. 227; fax: (215) 557-7154; e-mail: sstrickler@ndri.com. NCRR - Islet Cell Resource (ICR) With support from NCRR, 10 Islet Cell Resource (ICR) centers isolate, purify, and characterize human pancreatic islets for subsequent transplantation into patients with type I diabetes. The ICR centers procure whole pancreata and acquire relevant data about donors; improve islet isolation and purification techniques; distribute islets for use in approved clinical protocols; and perfect the methods of storage and shipping. In this way, the centers optimize the viability, function, and availability of islets and help clinical researchers capitalize on the recently reported successes in islet transplantation. Information on submitting requests for islet cells can be obtained from Richard A. Knazek, M.D., Division of Clinical Research, NCRR, NIH, 6705 Rockledge Drive, Bethesda, MD 20892. Phone (301) 435-0790; fax (301) 480-3661; e-mail: richardk@ncrr.nih.gov. NIA - SWAN Repository (longitudinal, multiethnic study of women at midlife including the menopausal transition) The SWAN Repository is a biologic specimen bank of the Study of Women’s Health Across the Nation (SWAN). The SWAN cohort was recruited in 1996/7 and consists of 3302 African-American, Caucasian, Chinese-American, Hispanic, and Japanese-American women. The SWAN Repository contains blood and urine specimens from each study participant’s annual visit, at which time medical and health history, psychosocial measures, biological measures, and anthropometric data are also collected. In addition, a subset of participants provide urine samples over the length of one menstrual cycle each year. All of these samples are in the SWAN Repository and are available to researchers who wish to study the midlife and menopausal transition. A DNA sample repository for SWAN is in development. To learn more about the SWAN Repository and how to apply to use SWAN Repository specimens, contact the Web site at http://www.swanrepository.com or Dr. MaryFran Sowers, University of Michigan, School of Public Health, Epidemiology Dept., (734) 936-3892; e-mail: mfsowers@umich.edu. HUMAN AND ANIMAL CELL AND BIOLOGIC REAGENT RESOURCES NIDDK - National Hormone and Peptide Program The National Hormone and Peptide Program (NHPP) offers peptide hormones and their antisera, tissues (rat hypothalami), and miscellaneous reagents to qualified investigators. These reagents are supplied for research purposes only, not for therapeutic, diagnostic, or commercial uses. These materials can be obtained from Dr. A. F. Parlow of the Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA. A more complete description of resources within this program is provided in The Endocrine Society journals. Direct scientific-technical inquiry to NHPP Scientific Director, Dr. Al Parlow, at phone: (310) 222-3537; fax: (310) 222-3432; e-mail: parlow@humc.edu. Visit the NHPP Web site at http://www.humc.edu/hormones. NICHD - National Hormone and Pituitary Program (see NIDDK listing) Following is a list of reagents currently available through the resources of NICHD: Androgen receptor and peptide antigen Recombinant monkey (cynomolgus) and baboon luteinizing hormone and follicle-stimulating hormone and antisera NIA - Aging Cell Bank To facilitate aging research on cells in culture, the NIA provides support for the Aging Cell Bank located at the Coriell Institute for Medical Research in Camden, NJ. The Aged Cell Bank provides fibroblast, lymphoblastoid, and differentiated cell lines from a wide range of human age-related conditions and other mammalian species, as well as DNA from a limited subset of cell lines. For further information, the Aged Cell Bank catalog can be accessed at http://locus.umdnj.edu/nia or contact Dr. Donald Coppock at 1-800-752-3805. NCRR - Various Cell Repositories NCRR maintains the following cell repository resources: American Type Culture Collection, National Cell Culture Center, National Stem Cell Resource, and the Yeast Genetic Stock Center. Further information regarding these resources may be obtained through the NCRR Web site at: www.ncrr.nih.gov/ncrrprog/cmpdir/BIOLOG.asp. ANIMAL RESOURCES NIA - Aging Rodent Resources NIA maintains both rat and mouse colonies for use by the scientific community. The animals available range in age from 1 to 36 months. A repository of fresh-frozen tissue from the NIA aged rodent colonies is stocked with tissue from mouse and rat strains, including caloric-restricted BALB/c mice. The NIA also maintains a colony of calorically restricted rodents of selected genotypes, which are available to the scientific community. For further information, please refer to the Aged Rodent information handbook at http://www.nih.gov/nia/research/rodent.htm or contact Dr. Nancy Nadon, Office of Biological Resources and Resource Development, NIA. Phone: (301) 496-0181; fax: (301) 402-5597; e-mail: rodents@nia.nih.gov. NCRR - Mutant Mouse Regional Resource Centers (MMRRC) The Mutant Mouse Regional Resource Center (MMRRC) Program consists of centers that collectively operate as a one-stop shop to serve the biomedical research community. Investigators who have created select mutant mouse models may donate their models to an MMRRC for broad dissemination to other investigators who request them for noncommercial research investigations related to human health, disease, and treatments. The NCRR Division of Comparative Medicine (DCM) supports the MMRRCs, which are electronically linked through the MMRRC Informatics Coordinating Center (ICC) to function as one facility. The ICC, located at The Jackson Laboratory in Bar Harbor, ME, provides database and other informatics support to the MMRRC to give the research community a single entry point to the program. Further information can be obtained from the Web site at http://www.mmrrc.org, or from Franziska Grieder, D.V.M., Ph.D., Division of Comparative Medicine, NCRR. Phone (301) 435-0744; fax: (301) 480-3819; e-mail: griederf@ncrr.nih.gov. NCRR - Induced Mutant Mouse Resource (IMR) The Induced Mutant Mouse Resource (IMR) at The Jackson Laboratory provides researchers with genetically engineered mice (transgenic, targeted mutant, retroviral insertional mutant, and chemically induced mutant mice). The function of the IMR is to select, import, cryopreserve, maintain, and distribute these important strains of mice to the research community. To improve their value for research, the IMR also undertakes genetic development of stocks, such as transferring mutant genes or transgenes to defined genetic backgrounds and combining transgenes and/or targeted mutations to create new mouse models for research. Over 800 mutant stocks have been accepted by the IMR. Current holdings include models for research on cancer, immunological and inflammatory diseases, neurological diseases and behavioral disorders, cardiovascular diseases, developmental disorders, metabolic and other diseases, reporter (e.g. GFP) and recombinase (e.g. cre/loxP) strains. About 8 strains a month are being added to the IMR holdings. A list of all strains may be obtained from the IMR Web site: www.jax.org/resources/documents/imr/. Online submission forms are also available on that site. All mice can be ordered by calling The Jackson Laboratory’s Customer Service Department at 1-800-422-MICE or (207) 288-5845 or by faxing (207) 288-6150. NIDDK - Mouse Metabolic Phenotyping Centers The mission of the Mouse Metabolic Phenotyping Centers is to provide the scientific community with standardized, high-quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity, and related disorders. Researchers can ship mice to one of the four Centers (University of Cincinnati, University of Texas Southwestern Medical Center, Vanderbilt University, and Yale University) and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition, energy balance, eating and exercise, organ function and morphology, physiology, and histology. Many tests are done in living animals and are designed to elucidate the subtle hallmarks of metabolic disease. Information, including a complete list of available tests, can be found at www.mmpc.org, or contact Dr. Maren R. Laughlin, NIDDK, at (301) 594-8802; e-mail: Maren.Laughlin@nih.gov; or Dr. Kristin Abraham, NIDDK, at (301) 451-8048; e-mail: abrahamk@extra.niddk.nih.gov. NCRR - National Primate Research Centers (NPRCs) National Primate Research Centers (NPRCs)* are a network of eight highly specialized facilities for nonhuman primates (NHP) research. Funded by grants through NCRR’s Division of Comparative Medicine (DCM), each center, staffed with experienced research and support staff, provides the appropriate research environment to foster the development of NHP models of human health and disease for biomedical investigations. The NPRCs are affiliated with academic institutions and are accessible to eligible biomedical and behavioral investigators supported by research project grants from the National Institutes of Health and other sources. Further information may be obtained from the notice, Procedures for Accessing Regional Primate Research Centers, published in the NIH Guide for Grants and Contracts at http://grants2.nih.gov/grants/guide/notice-files/not97-014.html, or from Jerry A. Robinson, Ph.D., Director, National Primate Research Centers and AIDS Animal Models Program, Division of Comparative Medicine, NCRR. Phone: (301) 435-0744; fax: (301) 480-3819; e-mail: JerryR@ncrr.nih.gov. *The National Primate Research Centers were formerly called Regional Primate Research Centers. The name was changed in April 2002 to reflect the expanded role of the centers. NIA - Nonhuman Primates, Aging Set-Aside Colony NIA maintains approximately 200 nonhuman primates (M. mulatta) at four National Primate Research Centers (see above) for conducting research on aging. These animals range in age from 18 to 35 years. While these animals are predominantly reserved for non-invasive research, exceptions can be made to this policy. For further information, please contact Dr. Nancy Nadon, Office of Biological Resources and Resource Development, NIA. Phone: (301) 496-0181; fax: (301) 402-0010; e-mail: nadonn@nia.nih.gov. NIA - Obesity, Diabetes and Aging Animal Resource (ODAAR) The NIA supports a colony of aged rhesus macaques, many of which are obese and/or diabetic. This is a long-term colony of monkeys housed at the University of Maryland. They have been extensively and longitudinally characterized for general health variables, blood chemistry, food intake, and body weight. Diabetic monkeys are tested daily for urine glucose and ketone levels, and prediabetic monkeys are tested weekly. Data for some of the monkeys extends as far back as 15 years. This unique resource is available for collaborative studies. ODAAR has a significant amount of stored tissue collected at necropsy and stored blood collected longitudinally. Serial blood collection or tissue collection at necropsy can also be performed prospectively. Testing and imaging can also be performed on the monkeys. Inquiries regarding collaborative studies using the ODAAR colony should be directed to: Barbara C. Hansen, Ph.D., Director, Obesity and Diabetes Research Center, University of Maryland, 10 South Pine St., Baltimore, MD 21201-1192, Phone: (410) 706-3168; fax: (410) 706-7540; e-mail: bchansen@aol.com. NCRR - Various Animal Resources NCRR maintains the following animal resources: Animal Models and Genetic Stocks, Chimpanzee Biomedical Research Program, NIH Animal Genetic Resource, and the Specific Pathogen Free Macaque Breeding and Research Program. Further information regarding these and other resources may be obtained through the NCRR Web site at www.ncrr.nih.gov/comparative_med.asp. MISCELLANEOUS RESOURCES NCRR - National Gene Vector Laboratories (NGVLs) The National Gene Vector Laboratories (NGVLs), with core funding from NCRR, serve as a resource for researchers to obtain adequate quantities of clinical-grade vectors for human gene transfer protocols. The vector types include retrovirus, lentivirus, adenovirus, adeno-associated virus, and herpes-virus. The NGVLs consist of three vector production centers at: Baylor College of Medicine; City of Hope National Medical Center and Beckman Research Institute; and Indiana University, which also serves as the Coordinating Center for all the laboratories. Two additional laboratories conduct toxicology studies for NGVL-approved investigators. These laboratories are located at the Southern Research Institute and the University of Florida. Additional information about the process for requesting vector production and/or pharmacology/toxicology support should be directed to Ms. Lorraine Rubin, NGVL Project Coordinator, Indiana University School of Medicine. Phone: (317) 274-4519; fax: (317) 278-4518; e-mail: lrubin@iupui.edu. The NGVL Coordinating Center at Indiana University also hosts a Web site: http://www.ngvl.org/. NCRR - General Clinical Research Centers (GCRCs) The General Clinical Research Centers (GCRCs) are a national network of 80 centers that provide optimal settings for medical investigators to conduct safe, controlled, state-of-the-art in-patient and out-patient studies of both children and adults. GCRCs also provide infrastructure and resources that support several career development opportunities. Investigators who have research project funding from the National Institutes of Health (NIH) and other peer-reviewed sources may apply to use GCRCs. Because the GCRCs support a full spectrum of patient-oriented scientific inquiry, researchers who use these centers can benefit from collaborative, multidisciplinary research opportunities. To request access to a GCRC facility, eligible investigators should initially contact a GCRC program director, listed in the National Center for Research Resources (NCRR) Clinical Research Resources Directory (www.ncrr.nih.gov/ncrrprog/clindir/crdirectory.asp). Further information can be obtained from Anthony R. Hayward, M.D., Director, Division of Clinical Research, National Center for Research Resources at NIH. Phone: (301) 435-0790; e-mail: haywarda@ncrr.nih.gov.