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Journal articles on the topic 'Complementation analysis'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

Delvaux, Steven, and Marc Van Barel. "Structures Preserved by Schur Complementation." SIAM Journal on Matrix Analysis and Applications 28, no. 1 (January 2006): 229–52. http://dx.doi.org/10.1137/040621417.

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2

Chajda, Ivan, and R. Padmanabhan. "Lattices with unique complementation." Acta Scientiarum Mathematicarum 83, no. 12 (2017): 31–34. http://dx.doi.org/10.14232/actasm-016-514-2.

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3

Cifuentes, V., G. Hermosilla, and G. Pincheira. "Genetic complementation analysis in Pycnoporus cinnabarinus." Fungal Genetics Reports 40, no. 1 (January 1, 1993): 28–29. http://dx.doi.org/10.4148/1941-4765.1398.

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4

Wang, Xianghong, Majid Hafezparast, and John R. W. Masters. "Complementation analysis of testis tumor cells." Cancer Genetics and Cytogenetics 98, no. 1 (October 1997): 56–62. http://dx.doi.org/10.1016/s0165-4608(96)00398-6.

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5

Seneta, E. "Complementation in Stochastic Matrices and the GTH Algorithm." SIAM Journal on Matrix Analysis and Applications 19, no. 2 (April 1998): 556–63. http://dx.doi.org/10.1137/s0895479896310172.

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6

Belote, J. M., F. M. Hoffmann, M. McKeown, R. L. Chorsky, and B. S. Baker. "Cytogenetic analysis of chromosome region 73AD of Drosophila melanogaster." Genetics 125, no. 4 (August 1, 1990): 783–93. http://dx.doi.org/10.1093/genetics/125.4.783.

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Abstract The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of complementation groups within this interval. Eighteen complementation groups were defined and mapped to the 73A2-73B7 region, which is comprised of 17 polytene bands. These complementation groups include the previously known scarlet (st), transformer (tra) and Dominant temperature-sensitive lethal-5 (DTS-5) genes, as well as 13 new recessive lethal complementation groups and one male and female sterile locus. One of the newly identified lethal complementation groups corresponds to the molecularly identified abl locus, and another gene is defined by mutant alleles that exhibit an interaction with the abl mutants. We also recovered several mutations in the 73C1-D1.2 interval, representing two lethal complementation groups, one new visible mutant, plucked (plk), and a previously known visible, dark body (db). There is no evidence of a complex of sex determination genes in the region near tra.

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7

Ndiribe, Matthew Onyebuchi. "A Minimalist Analysis of Verbal Complementation in Igbo." Journal of Language Teaching and Research 11, no. 5 (September 1, 2020): 671. http://dx.doi.org/10.17507/jltr.1105.02.

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The study investigates the verbal complementation in Igbo using the Minimalist perspective. In discussing the subject matter, such concepts as verb complementation, reflexive complementation and infinitival complementation are analysed. The objectives of the study are to find out how co-occurrence restrictions, thematic roles, theta criterion, subcategorisation frame and c-command could play crucial roles in selecting the complements of verbs. The study made use of written data, oral communication and introspection as the methods of data collection. The research adopted the standard Igbo as the area of study. The data are analysed using word- for- word English transliteration and then followed by English semantic gloss. The study discovers that the Igbo verbal complementation obeys the rules of adjacency and c-command. The verbs subcategorise its complements based on the relationships existing between the verbs and the complements. The head verb and its complement establish the path of union and intersection in the syntactic form. The concept of theta criterion determines the true nomenclature of the subjects in linguistic structures.

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8

Kerppola, Tom K. "Visualization of molecular interactions using bimolecular fluorescence complementation analysis: Characteristics of protein fragment complementation." Chemical Society Reviews 38, no. 10 (2009): 2876. http://dx.doi.org/10.1039/b909638h.

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9

Moon, A., and W. J. Rhead. "Complementation analysis of fatty acid oxidation disorders." Journal of Clinical Investigation 79, no. 1 (January 1, 1987): 59–64. http://dx.doi.org/10.1172/jci112808.

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10

Velayos, Antonio, Marı́a Angeles López-Matas, Marı́a José Ruiz-Hidalgo, and Arturo P. Eslava. "Complementation Analysis of Carotenogenic Mutants ofMucor circinelloides." Fungal Genetics and Biology 22, no. 1 (August 1997): 19–27. http://dx.doi.org/10.1006/fgbi.1997.0998.

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11

Mukherjee, Joybrato, and Sebastian Hoffmann. "Describing verb-complementational profiles of New Englishes." English World-Wide 27, no. 2 (July 6, 2006): 147–73. http://dx.doi.org/10.1075/eww.27.2.03muk.

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The present paper investigates the emergence of local norms in Indian English at the level of verb complementation, an area which so far has not attracted much attention in research into New Englishes. In attempting to describe the verb-complementational profile of Indian English, we offer a pilot study which combines a descriptive aim and a methodological aim. At the descriptive level, the present article focuses on ditransitive verbs and their complementation and addresses two related questions: (1) To what extent do the frequency and distribution of complementation patterns of specific ditransitive verbs (e.g. give) differ between Indian English and British English? (2) To what extent is the basic ditransitive pattern with two object noun phrases (e.g. in he sent Mary his warmest wishes) associated with different verbs in British English and Indian English? The present paper reveals that in both regards there are clear and identifiable differences in verb complementation between the two varieties. At the methodological level, this pilot study combines the use of balanced and representative subcorpora from the International Corpus of English (ICE) with the in-depth analysis of a much larger database that has been extracted from the Internet archive of the daily Indian newspaper The Statesman. This makes it possible to also detect examples of low-frequency constructions in Indian English, e.g. sporadic cases of ditransitive complementation of verbs such as advise, gift and impart.

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12

Darcy, P. K., Z. Wilczynska, and P. R. Fisher. "Genetic analysis of Dictyostelium slug phototaxis mutants." Genetics 137, no. 4 (August 1, 1994): 977–85. http://dx.doi.org/10.1093/genetics/137.4.977.

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Abstract Mapping and complementation analysis with 17 phototaxis mutations has established 11 complementation groups phoA-phoK distributed over six linkage groups. Statistical calculations from the complementation data yielded 17 as the maximum likelihood estimate of the number of pho genes assuming all loci are equally mutable. Most of the phototaxis mutants were found to exhibit bimodal phototaxis and all were found to be impaired in positive thermotaxis supporting convergence of the photosensory and thermosensory pathways. The thermotaxis mutant HPF228 was unaltered in phototaxis suggesting that the mutation in this strain affects a gene product whose site of action is before the convergence of the two pathways. Other phenotypes such as multiple tip formation by aggregates, stumpy fruiting bodies with short or absent stalks and short migration were associated with some pho alleles suggesting multiple biological roles for some gene products important in phototransduction.

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13

HATTORI, Mitsuru, and Takeaki OZAWA. "Split Luciferase Complementation for Analysis of Intracellular Signaling." Analytical Sciences 30, no. 5 (2014): 539–44. http://dx.doi.org/10.2116/analsci.30.539.

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14

Lin, Ho-Pi, Claudius Vincenz, Kevin W. Eliceiri, Tom K. Kerppola, and Brenda M. Ogle. "Bimolecular fluorescence complementation analysis of eukaryotic fusion products." Biology of the Cell 102, no. 9 (September 2010): 525–37. http://dx.doi.org/10.1042/bc20100033.

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15

Zdzienicka, M. Z., W. Jongmans, M. Oshimura, A. Priestley, G. F. Whitmore, and P. A. Jeggo. "Complementation Analysis of the Murine scid Cell Line." Radiation Research 143, no. 3 (September 1995): 238. http://dx.doi.org/10.2307/3579209.

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16

Jock, Carissa A., Lakshmidevi Pulakat, Saehong Lee, and Narasaiah Gavini. "Nucleotide Sequence and Genetic Complementation Analysis oflepfromAzotobacter vinelandii." Biochemical and Biophysical Research Communications 239, no. 2 (October 1997): 393–400. http://dx.doi.org/10.1006/bbrc.1997.7452.

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17

Schilk, Marco, Joybrato Mukherjee, Christopher Nam, and Sach Mukherjee. "Complementation of ditransitive verbs in South Asian Englishes: a multifactorial analysis." Corpus Linguistics and Linguistic Theory 9, no. 2 (October 25, 2013): 187–225. http://dx.doi.org/10.1515/cllt-2013-0001.

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AbstractThis paper examines parallels and differences between South Asian Englishes and British English with regard to various factors driving the selection of verb-complementation patterns. Focusing on the prototypical ditransitive verb give and its complementation, we use large web-derived corpora and distinguish between two possible response cases, one based on the dative and prepositional construction (i.e. the dative alternation), the other including monotransitive complementation. Our data has been additionally coded for a number of potential driving factors, such as pronominality and discourse accessibility of the participants in the constructions. Applying a model-exploration technique we isolate the main driving factors for the varieties under scrutiny (Indian English, Pakistani English and British English) and analyze their influence on pattern selection based on a multinomial logistic regression formulation. Our findings show that, while there is a large area of overlap between the varieties, Pakistani English is closer to British English with regard to relevant driving factors than Indian English. Furthermore, we reveal interesting parallels between all three varieties in the use of monotransitive complementation.

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18

Plichko, Anatolij M., and David Yost. "The Radon-Nikodým Property Does Not Imply the Separable Complementation Property." Journal of Functional Analysis 180, no. 2 (March 2001): 481–87. http://dx.doi.org/10.1006/jfan.2000.3689.

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19

Koszmider, Piotr, and Przemysław Zieliński. "Complementation and decompositions in some weakly Lindelöf Banach spaces." Journal of Mathematical Analysis and Applications 376, no. 1 (April 2011): 329–41. http://dx.doi.org/10.1016/j.jmaa.2010.11.014.

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20

Kalenda, Ondřej F. K., and Wiesław Kubiś. "Complementation in spaces of continuous functions on compact lines." Journal of Mathematical Analysis and Applications 386, no. 1 (February 2012): 241–57. http://dx.doi.org/10.1016/j.jmaa.2011.07.057.

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21

Joenje, H., JR Lo ten Foe, AB Oostra, CG van Berkel, MA Rooimans, T. Schroeder- Kurth, RD Wegner, JJ Gille, M. Buchwald, and F. Arwert. "Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype." Blood 86, no. 6 (September 15, 1995): 2156–60. http://dx.doi.org/10.1182/blood.v86.6.2156.bloodjournal8662156.

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Fanconi anemia (FA) is an autosomal recessive disease with diverse clinical symptoms, life-threatening progressive panmyelopathy, and cellular hypersensitivity to cross-linking agents. Currently, 4 genetic subtypes or complementation groups (FA-A through FA-D) have been distinguished among 7 unrelated FA patients. We report the use of genetically marked FA lymphoblastoid cell lines representing each of the 4 presently known complementation groups to classify 13 unrelated FA patients through cell fusion and complementation analysis. Twelve cell lines failed to complement cross-linker sensitivity in fusion hybrids with only 1 of the 4 reference cell lines and could thus be unambiguously classified as FA-A (7 patients), FA-C (4 patients), or FA- D (1 patient). One cell line complemented all 4 reference cell lines and therefore represents a new complementation group, designated FA-E. These results imply that at least 5 genes appear to be involved in a pathway that, when defective, causes bone marrow failure in FA patients.

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22

Tiong, S. Y., and D. Nash. "Genetic analysis of the adenosine3 (Gart) region of the second chromosome of Drosophila melanogaster." Genetics 124, no. 4 (April 1, 1990): 889–97. http://dx.doi.org/10.1093/genetics/124.4.889.

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Abstract The Gart gene of Drosophila melanogaster is known, from molecular biological evidence, to encode a polypeptide that serves three enzymatic functions in purine biosynthesis. It is located in polytene chromosome region 27D. One mutation in the gene (ade3(1)) has been described previously. We report here forty new ethyl methanesulfonate-induced mutations selected aga!nst a synthetic deficiency of the region from 27C2-9 to ++28B3-4. The mutations were characterized cytogenetically and by complementation analysis. The analysis apparently identifies 12 simple complementation groups. In addition, two segments of the chromosome exhibit complex complementation behavior. The first, the 28A region, gave three recessive lethals and also contains three known visible mutants, spade (spd), Sternopleural (Sp) and wingless (wg); a complex pattern of genetic interaction in the region incorporates both the new and the previously known mutants. The second region is at 27D, where seven extreme semilethal mutations give a complex complementation pattern that also incorporates ade3(1). Since ade3(1) is defective in one of the enzymatic functions encoded in the Gart gene, we assume the other seven also affect the gene. The complexity of the complementation pattern presumably reflects the functional complexity of the gene product. The phenotypic effects of the mutants at 27D are very similar to those described for ade2 mutations, which also interrupt purine biosynthesis.

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23

Wei, Ho-Chun, Huidy Shu, and James V. Price. "Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster." Genome 46, no. 6 (December 1, 2003): 1049–58. http://dx.doi.org/10.1139/g03-081.

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Assigning functional significance to completed genome sequences is one of the next challenges in biological science. Conventional genetic tools such as deficiency chromosomes help assign essential complementation groups to their corresponding genes. We describe an F2 genetic screen to identify lethal mutations within cytogenetic region 61D-61F of the third chromosome of Drosophila melanogaster. One hundred sixteen mutations were identified by their failure to complement both Df(3L)bab-PG and Df(3L)3C7. These alleles were assigned to 14 complementation groups and 9 deficiency intervals. Complementation groups were ordered using existing deficiencies, as well as new deficiencies generated in this study. With the aid of the genomic sequence, genetic and physical maps in the region were correlated by use of PCR to localize the breakpoints of deficiencies within a 268-kb genomic contig (GenBank accession No. AC005847). Six essential complementation groups were assigned to specific genes, including genes encoding a porphobilinogen deaminase and a Sac1-like protein.Key words: Drosophila, functional genomics, porphobilinogen deaminase, synaptojanin.

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24

Ferrer, Jesús. "The controlled separable complementation property and monolithic compacta." Banach Journal of Mathematical Analysis 8, no. 2 (2014): 67–78. http://dx.doi.org/10.15352/bjma/1396640052.

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25

Brumos, Javier, Benjamin G. Bobay, Cierra A. Clark, Jose M. Alonso, and Anna N. Stepanova. "Structure–Function Analysis of Interallelic Complementation in ROOTY Transheterozygotes." Plant Physiology 183, no. 3 (April 29, 2020): 1110–25. http://dx.doi.org/10.1104/pp.20.00310.

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26

Pélissier, Aline, and Alain Těte. "Analysis of the logical characteristics of a complementation task." International Journal of Psychology 29, no. 2 (January 1994): 249–58. http://dx.doi.org/10.1080/00207599408246544.

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27

Slama, A., M. Brivet, A. Boutron, A. Legrand, J.-M. Saudubray, and F. Demaugre. "Complementation Analysis of Carnitine Palmitoyltransferase I and II Defects." Pediatric Research 40, no. 4 (October 1996): 542–46. http://dx.doi.org/10.1203/00006450-199610000-00005.

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28

Sadiq, May F., and Christopher D. Town. "Characterization and complementation analysis of sporogenous mutants ofDictyostelium discoideum." Developmental Genetics 12, no. 4 (1991): 272–80. http://dx.doi.org/10.1002/dvg.1020120404.

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29

Frazzon, Jeverson, and Irene Silveira Schrank. "Sequencing and complementation analysis of thenifUSV genes fromAzospirillum brasilense." FEMS Microbiology Letters 159, no. 2 (February 1998): 151–58. http://dx.doi.org/10.1111/j.1574-6968.1998.tb12854.x.

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30

Gonzalez-Santos, J. M. "A complementation method for functional analysis of mammalian genes." Nucleic Acids Research 33, no. 10 (June 2, 2005): e94-e94. http://dx.doi.org/10.1093/nar/gni093.

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31

Aminov, Rustern I., Takafumi Nagamine, Koretsugu Ogata, Mutsumi Sugiura, Kiyoshi Tajima, and Yoshimi Benno. "Cloning, sequencing and complementation analysis of therecAgene fromPrevotella ruminicola." FEMS Microbiology Letters 144, no. 1 (October 1996): 53–59. http://dx.doi.org/10.1111/j.1574-6968.1996.tb08508.x.

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32

Pascal, Geraldine, and Graeme Milligan. "Functional Complementation and the Analysis of Opioid Receptor Homodimerization." Molecular Pharmacology 68, no. 3 (June 20, 2005): 905–15. http://dx.doi.org/10.1124/mol.105.013847.

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33

Brivet, M., A. Slama, H. Ogier, A. Boutron, F. Demaugre, J. M. Saudubray, and A. Lemonnier. "Diagnosis of carnitine acylcarnitine translocase deficiency by complementation analysis." Journal of Inherited Metabolic Disease 17, no. 3 (1994): 271–74. http://dx.doi.org/10.1007/bf00711805.

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34

Dale, Renee, and Naohiro Kato. "Truly quantitative analysis of the firefly luciferase complementation assay." Current Plant Biology 5 (April 2016): 57–64. http://dx.doi.org/10.1016/j.cpb.2016.02.002.

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35

Dai, Hai-Qiang, Zhuoyi Liang, Amelia N. Chang, Aimee M. Chapdelaine-Williams, Beatriz Alvarado, Alex A. Pollen, Frederick W. Alt, and Bjoern Schwer. "Direct analysis of brain phenotypes via neural blastocyst complementation." Nature Protocols 15, no. 10 (August 10, 2020): 3154–81. http://dx.doi.org/10.1038/s41596-020-0364-y.

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36

Bedell, Mary A., Linda S. Cleveland, T. Norene O'Sullivan, Neal G. Copeland, and Nancy A. Jenkins. "Deletion and Interallelic Complementation Analysis of Steel Mutant Mice." Genetics 142, no. 3 (March 1, 1996): 935–44. http://dx.doi.org/10.1093/genetics/142.3.935.

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Abstract Mutations at the Steel (Sl) locus produce pleiotropic effects on viability as well as hematopoiesis, pigmentation and fertility. Several homozygous viable Sl alleles have previously been shown to contain either structural alterations in mast cell growth factor (Mgf) or regulatory mutations that affect expression of the Mgf gene. More severe Sl alleles cause lethality to homozygous embryos and all lethal Sl alleles examined to date contain deletions that remove the entire Mgf coding region. As the timing of the lethality varies from early to late in gestation, it is possible that some deletions may affect other closely linked genes in addition to Mgf We have analyzed the extent of deleted sequences in seven homozygous lethal Sl alleles. The results of this analysis suggest that late gestation lethality represents the Sl null phenotype and that pen-implantation lethality results from the deletion of at least one essential gene that maps proximal to Sl. We have also examined gene dosage effects of Sl by comparing the phenotypes of mice homozygous and hemizygous for each of four viable Sl alleles. Lastly, we show that certain combinations of the viable Sl alleles exhibit interallelic complementation. Possible mechanisms by which such complementation could occur are discussed.

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37

Zhu, Jiahao, Shengjun Ji, Qunchao Hu, Qingqing Chen, Zhengcao Liu, Jinchang Wu, and Ke Gu. "The prognostic value of excission repair cross-complementation group one enzyme expression in locally advanced cervical carcinoma patients treated with cisplatin–based treatment: a meta–analysis." International Journal of Gynecologic Cancer 29, no. 1 (January 2019): 35–41. http://dx.doi.org/10.1136/ijgc-2018-000027.

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BackgroundRecently, several studies observed that locally advanced cervical carcinoma with negative excision repair crross-complementation group one enzyme expression has better outcomes in cisplatin-based chemotherapy or chemoradiotherapy than carcinoma with positive excission repair cross-complementation group one enzyme expression. In this meta-analysis, we quantitatively evaluated the prognostic value of excission repair cross-complementation group one enzyme expression in locally advanced cervical carcinoma patients receiving platinum-based chemotherapy or chemoradiotherapy.MaterialsA systematic search for relevant studies was conducted in the PubMed, Cochrane Library, EMBASE and Medline databases. Fixed- or random-effects models were used for pooled analysis. The endpoints were overall survival and disease-free survival () reported as ORs and 95% CIs. The effects of excission repair cross-complementation group one enzyme expression on the clinicopathological parameters were measured by the pooled ORs and their 95% CIs.ResultsEight studies (612 patients in total) satisfied the inclusion criteria. Negative/low excission repair cross-complementation group one enzyme expression was significantly associated with better overall survival (OR, 1.92; 95% CI, 1.22 to 3.05; P = 0.005) and disease-free survival (OR, 5.77; 95% CI, 1.90 to 17.54; P = 0.002). Additionally, there were significant associations between excission repair cross-complementation group one enzyme expression and lymph node metastasis (OR, 2.57; 95% CI, 1.28 to 5.16; P = 0.008).ConclusionsThis meta-analysis suggested that pretreatment excission repair cross-complementation group one enzyme expression might be a useful biomarker to predict prognoses for locally advanced cervical carcinoma patients receiving platinum-based chemotherapy or chemoradiotherapy.

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38

O'Brien, M. A., M. S. Roberts, and P. H. Taghert. "A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene in Drosophila melanogaster." Genetics 137, no. 1 (May 1, 1994): 121–37. http://dx.doi.org/10.1093/genetics/137.1.121.

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Abstract We have analyzed the FMRFamide neuropeptide gene region of Drosophila melanogaster. This gene maps to the 46C region of chromosome 2R; this interval previously was not well characterized. For this genetic and molecular analysis, we have used X-ray mutagenesis, EMS mutagenesis, and the recently reported local P element transposition method. We identified four overlapping deletions, two of which have proximal breakpoints that define a 50-60-kb region surrounding the FMRFamide gene in 46C. To this small region, we mapped three lethal complementation groups; 10 additional lethal complementation groups were mapped to more distal regions of 46CD. One of these groups corresponds to even-skipped, the other 12 are previously unidentified. Using various lines of evidence we excluded the possibility that FMRFamide corresponds to any of the three lethal complementation groups mapping to its immediate 50-60-kb vicinity. The positions of two of the three lethal complementation groups were identified with P elements using a local transposition scheme. The third lethal complementation group was excluded as being FMRFamide mutants by sequence analysis and by immunocytochemistry with proFMRFamide precursor-specific antibodies. This analysis has (1) provided a genetic map of the 46CD chromosomal region and a detailed molecular map of a portion of the 46C region and (2) provided additional evidence of the utility of local transposition for targeting nearby genes.

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39

FRIEDGUT, EHUD, ORNA KUPFERMAN, and MOSHE Y. VARDI. "BÜCHI COMPLEMENTATION MADE TIGHTER." International Journal of Foundations of Computer Science 17, no. 04 (August 2006): 851–67. http://dx.doi.org/10.1142/s0129054106004145.

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The complementation problem for nondeterministic word automata has numerous applications in formal verification. In particular, the language-containment problem, to which many verification problems is reduced, involves complementation. For automata on finite words, which correspond to safety properties, complementation involves determinization. The 2n blow-up that is caused by the subset construction is justified by a tight lower bound. For Büchi automata on infinite words, which are required for the modeling of liveness properties, optimal complementation constructions are quite complicated, as the subset construction is not sufficient. From a theoretical point of view, the problem is considered solved since 1988, when Safra came up with a determinization construction for Büchi automata, leading to a 2O(n log n) complementation construction, and Michel came up with a matching lower bound. A careful analysis, however, of the exact blow-up in Safra's and Michel's bounds reveals an exponential gap in the constants hiding in the O( ) notations: while the upper bound on the number of states in Safra's complementary automaton is n2n, Michel's lower bound involves only an n! blow up, which is roughly (n/e)n. The exponential gap exists also in more recent complementation constructions. In particular, the upper bound on the number of states in the complementation construction of Kupferman and Vardi, which avoids determinization, is (6n)n. This is in contrast with the case of automata on finite words, where the upper and lower bounds coincides. In this work we describe an improved complementation construction for nondeterministic Büchi automata and analyze its complexity. We show that the new construction results in an automaton with at most (0.96n)n states. While this leaves the problem about the exact blow up open, the gap is now exponentially smaller. From a practical point of view, our solution enjoys the simplicity of the construction of Kupferman and Vardi, and results in much smaller automata.

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40

Stanley, P. "Membrane mutants of animal cells: rapid identification of those with a primary defect in glycosylation." Molecular and Cellular Biology 5, no. 5 (May 1985): 923–29. http://dx.doi.org/10.1128/mcb.5.5.923.

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Membrane mutants of animal cells have been isolated by several laboratories, using a variety of selection protocols. The majority are lectin receptor mutants arising from altered glycosylation of membrane molecules. They have been obtained by selection for resistance to cytotoxic plant lectins or by alternative protocols designed, in many cases, to isolate different classes of receptor mutants. The identification of most membrane mutants expressing altered surface carbohydrates is rapidly achieved by determining their resistance to several lectins of different carbohydrate-binding specificities. For Chinese hamster ovary mutants, genetic novelty may subsequently be determined by complementation analysis with selected members of 10 recessive, glycosylation-defective complementation groups defined by this laboratory. In an attempt to identify new complementation groups, 11 Chinese hamster ovary membrane mutants independently isolated in different laboratories have been investigated for their lectin resistance and complementation properties. Only one new complementation group was defined by these studies. The remaining 10 mutants fell into complementation group 1, 2, 3, or 8. Although no evidence for intragenic complementation was observed, indirect evidence for different mutations within some genes was obtained. Seven of the independent isolates fell into complementation group 1, reflecting the high probability of isolating the Lec1 phenotype from Chinese hamster ovary populations. The results emphasize the importance of performing a genetic analysis before biochemical characterization of putative new membrane mutants.

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41

Stanley, P. "Membrane mutants of animal cells: rapid identification of those with a primary defect in glycosylation." Molecular and Cellular Biology 5, no. 5 (May 1985): 923–29. http://dx.doi.org/10.1128/mcb.5.5.923-929.1985.

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Membrane mutants of animal cells have been isolated by several laboratories, using a variety of selection protocols. The majority are lectin receptor mutants arising from altered glycosylation of membrane molecules. They have been obtained by selection for resistance to cytotoxic plant lectins or by alternative protocols designed, in many cases, to isolate different classes of receptor mutants. The identification of most membrane mutants expressing altered surface carbohydrates is rapidly achieved by determining their resistance to several lectins of different carbohydrate-binding specificities. For Chinese hamster ovary mutants, genetic novelty may subsequently be determined by complementation analysis with selected members of 10 recessive, glycosylation-defective complementation groups defined by this laboratory. In an attempt to identify new complementation groups, 11 Chinese hamster ovary membrane mutants independently isolated in different laboratories have been investigated for their lectin resistance and complementation properties. Only one new complementation group was defined by these studies. The remaining 10 mutants fell into complementation group 1, 2, 3, or 8. Although no evidence for intragenic complementation was observed, indirect evidence for different mutations within some genes was obtained. Seven of the independent isolates fell into complementation group 1, reflecting the high probability of isolating the Lec1 phenotype from Chinese hamster ovary populations. The results emphasize the importance of performing a genetic analysis before biochemical characterization of putative new membrane mutants.

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Lolle, Susan J., Wendy Hsu, and Robert E. Pruitt. "Genetic Analysis of Organ Fusion in Arabidopsis thaliana." Genetics 149, no. 2 (June 1, 1998): 607–19. http://dx.doi.org/10.1093/genetics/149.2.607.

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Abstract Postgenital organ fusion occurs most commonly during reproductive development and is important in many angiosperms during genesis of the carpel. Although a number of mutants have been described that manifest ectopic organ fusion, little is known about the genes involved in regulating this process. In this article we describe the characterization of a collection of 29 Arabidopsis mutants showing an organ fusion phenotype. Mapping and complementation analyses revealed that the mutant alleles define nine different loci distributed throughout the Arabidopsis genome. Multiple alleles were isolated for the four complementation groups showing the strongest organ fusion phenotype while the remaining five complementation groups, all of which show only weak floral organ fusion, have a single representative allele. In addition to fusion events between aerial parts of the shoot, some mutants also show abnormal ovule morphology with adjacent ovules joined together at maturity. Many of the fusion mutants isolated have detectable differences in the rate at which chlorophyll can be extracted; however, in one case no difference could be detected between mutant and wild-type plants. In three mutant lines pollen remained unresponsive to contact with the mutant epidermis, demonstrating that organ fusion and pollen growth responses can be genetically separated from one another.

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Morris, James R., Ji-long Chen, Stephen T. Filandrinos, Rebecca C. Dunn, Ridgely Fisk, Pamela K. Geyer, and Chao-ting Wu. "An Analysis of Transvection at the yellow Locus of Drosophila melanogaster." Genetics 151, no. 2 (February 1, 1999): 633–51. http://dx.doi.org/10.1093/genetics/151.2.633.

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Abstract Studies of a wide variety of organisms have shown that homologous sequences can exert a significant impact on each other, resulting in changes in gene sequence, gene expression, chromatin structure, and global chromosome architecture. Our work has focused on transvection, a process that can cause genes to be sensitive to the proximity of a homologue. Transvection is seen at the yellow gene of Drosophila, where it mediates numerous cases of intragenic complementation. In this article, we describe two approaches that have characterized the process of transvection at yellow. The first entailed a screen for mutations that support intragenic complementation at yellow. The second involved the analysis of 53 yellow alleles, obtained from a variety of sources, with respect to complementation, molecular structure, and transcriptional competence. Our data suggest two ways in which transvection may be regulated at yellow: (1) a transcriptional mechanism, whereby the ability of an allele to support transvection is influenced by its transcriptional competency, and (2) a structural mechanism, whereby the pairing of structurally dissimilar homologues results in conformational changes that affect gene expression.

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Deshors, Sandra C., and Stefan Th Gries. "Profiling verb complementation constructions across New Englishes." International Journal of Corpus Linguistics 21, no. 2 (August 29, 2016): 192–218. http://dx.doi.org/10.1075/ijcl.21.2.03des.

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In this paper, we explore verb complementation patterns with to and ing in native English (British and American English) as compared to three Asian Englishes (Hong Kong, Indian, and Singaporean English). Based on data from the International Corpus of English annotated for variables describing the matrix verb and the complement, we run two random forests analyses to determine where the Asian Englishes have developed complementation preferences different from the two native speaker varieties. We find not only a variety of differences between the Asian and the native Englishes, but also that the Asian Englishes are more similar (i.e. ‘better predicted by’) the American English data. Further, as the first study of its kind to extend the MuPDAR approach from the now frequent regression analyses to random forests analysis, this study adds a potentially useful analytical tool to the often messy and skewed observational data corpus linguists need to deal with.

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Pelsy, F., and M. Gonneau. "Genetic and biochemical analysis of intragenic complementation events among nitrate reductase apoenzyme-deficient mutants of Nicotiana plumbaginifolia." Genetics 127, no. 1 (January 1, 1991): 199–204. http://dx.doi.org/10.1093/genetics/127.1.199.

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Abstract Intragenic complementation has been observed between apoenzyme nitrate reductase-deficient mutants (nia) of Nicotiana plumbaginifolia. In vivo as in vitro, the NADH-nitrate reductase (NR) activity in plants heterozygous for two different nia alleles was lower than in the wild type plant, but the plants were able to grow on nitrate as a sole nitrogen source. NR activity, absent in extracts of homozygous nia mutants was restored by mixing extracts from two complementing nia mutants. These observations suggest that NR intragenic complementation results from either the formation of heteromeric NR or from the interaction between two modified enzymes. Complementation was only observed between mutants retaining different partial catalytic activities of the enzyme. Results are in agreement with molecular data suggesting the presence of three catalytic domains in the subunit of the enzyme.

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Marchant, G. E., and D. G. Holm. "Genetic Analysis of the Heterochromatin of Chromosome 3 in Drosophila Melanogaster. II. Vital Loci Identified through Ems Mutagenesis." Genetics 120, no. 2 (October 1, 1988): 519–32. http://dx.doi.org/10.1093/genetics/120.2.519.

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Abstract Chromosome 3 of Drosophila melanogaster contains the last major blocks of heterochromatin in this species to be genetically analyzed. Deficiencies of heterochromatin generated through the detachment of compound-3 chromosomes revealed the presence of vital loci in the heterochromatin of chromosome 3, but an extensive complementation analysis with various combinations of lethal and nonlethal detachment products gave no evidence of tandemly repeated vital genes in this region. These findings indicate that the heterochromatin of chromosome 3 is genetically similar to that of chromosome 2. A more thorough genetic analysis of the heterochromatic regions has been carried out using the chemical mutagen ethyl methanesulfonate (EMS). Seventy-five EMS-induced lethals allelic to loci uncovered by detachment-product deficiencies were recovered and tested for complementation. In total, 12 complementation groups were identified, ten in the heterochromatin to the left of the centromere and two to the right. All but two complementation groups in the left heterochromatic block could be identified as separate loci through deficiency mapping. The interallelic complementation observed between some EMS-induced lethals, as well as the recovery of a temperature-sensitive allele for each of the two loci, provided further evidence that single-copy, transcribed vital genes reside in the heterochromatin of chromosome 3. Cytological analysis of three detachment-product deficiencies provided evidence that at least some of the genes uncovered in this study are located in the most distal segments of the heterochromatin in both arms. This study provides a detailed genetic analysis of chromosome 3 heterochromatin and offers further information on the genetic nature and heterogeneity of Drosophila heterochromatin.

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Heitzler, P., D. Coulson, M. T. Saenz-Robles, M. Ashburner, J. Roote, P. Simpson, and D. Gubb. "Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster." Genetics 135, no. 1 (September 1, 1993): 105–15. http://dx.doi.org/10.1093/genetics/135.1.105.

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Abstract A cytogenetic analysis of the 43A-E region of chromosome 2 in Drosophila melanogaster is presented. Within this interval 27 complementation groups have been identified by extensive F2 screens and ordered by deletion mapping. The region includes the cellular polarity genes prickle and spiny-legs, the segmentation genes costa and torso, the morphogenetic locus sine oculis and is bounded on its distal side by the eye-color gene cinnabar. In addition 19 novel lethal complementation groups and two semi-lethal complementation groups with morphogenetic escaper phenotypes are described.

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Sokolova, A. A. "Application of edge local complementation to McEliece cryptosystem structural analysis." Prikladnaya diskretnaya matematika. Prilozhenie, no. 10 (September 1, 2017): 142–44. http://dx.doi.org/10.17223/2226308x/10/56.

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Zill, Oliver A., Devin R. Scannell, Jeffrey Kuei, Meru Sadhu, and Jasper Rine. "Evolutionary Analysis of Heterochromatin Protein Compatibility by Interspecies Complementation inSaccharomyces." Genetics 192, no. 3 (August 24, 2012): 1001–14. http://dx.doi.org/10.1534/genetics.112.141549.

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Knipfer, Nancianne, Laila Nooruddin, and Thomas E. Shrader. "Development of an α-complementation system for mycobacterial promoter analysis." Gene 217, no. 1-2 (September 1998): 69–75. http://dx.doi.org/10.1016/s0378-1119(98)00361-8.

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