Relevant bibliographies by topics / Complete Freund's adjuvant (CFA)

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  2. Dissertations / Theses
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Academic literature on the topic 'Complete Freund's adjuvant (CFA)'

Author: Grafiati
Published: 4 June 2025
Last updated: 14 July 2025

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Journal articles on the topic "Complete Freund's adjuvant (CFA)"

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Arrau, Sylvia, Maité Rodríguez-Díaz, Bruce K. Cassels, et al. "Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja Saponaria Mol." Current Topics in Medicinal Chemistry 19, no. 11 (2019): 927–30. http://dx.doi.org/10.2174/1568026619666190509115741.

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Background: Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive effect of the major sapogenin, quillaic acid have been demonstrated (QA). Objective: To determine the antihyperalgesic effect of QA one and seven days after itpl administration of complete Freund's adjuvant (CFA) in male mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA)
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Sun, Siquan, Hidehiro Kishimoto, and Jonathan Sprent. "DNA as an Adjuvant: Capacity of Insect DNA and Synthetic Oligodeoxynucleotides to Augment T Cell Responses to Specific Antigen." Journal of Experimental Medicine 187, no. 7 (1998): 1145–50. http://dx.doi.org/10.1084/jem.187.7.1145.

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How strong adjuvants such as complete Freund's adjuvant (CFA) promote T cell priming to protein antigens in vivo is still unclear. Since the unmethylated CpG motifs in DNA of bacteria and other nonvertebrates are stimulatory for B cells and antigen-presenting cells, the strong adjuvanticity of CFA could be attributed, at least in part, to the presence of dead bacteria, i.e., a source of stimulatory DNA. In support of this possibility, evidence is presented that insect DNA in mineral oil has even stronger adjuvant activity than CFA by a number of parameters. Synthetic oligodeoxynucleotides (ODN
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Kim, Jae-Hyo, Hee-Kee Kim, Yong-Il Park, et al. "Moxibustion at ST36 Alleviates Pain in Complete Freund's Adjuvant-Induced Arthritic Rats." American Journal of Chinese Medicine 34, no. 01 (2006): 57–67. http://dx.doi.org/10.1142/s0192415x06003631.

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This study was to investigate the antinociceptive effects of moxibustion in a complete Freund's adjuvant (CFA)-induced arthritic rat model, and the effects of moxibustion on immunohistochemical changes at the spinal cord level. Moxibustion was applied to the ipsilateral (right) Zusanli (ST36) acupoint to the lesion side for 9 days to CFA-induced arthritic rats. The stepping force was measured as a behavioral test, c-Fos immunohistochemistry, NO production and nNOS Western blots were examined to evaluate antinociceptive effects. Moxibustion at ST36 significantly improved the stepping force in t
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Kahn, Daniel A., D. Clay Archer, Daniel P. Gold, and Carolyn J. Kelly. "Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase." Journal of Experimental Medicine 193, no. 11 (2001): 1261–68. http://dx.doi.org/10.1084/jem.193.11.1261.

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Rodents immunized with complete Freund's adjuvant (CFA) are resistant to subsequent attempts to induce autoimmune disease, while animals immunized with incomplete Freund's adjuvant (IFA) remain susceptible. Mycobacterial extracts can stimulate inducible nitric oxide synthase (NOS2) gene transcription. Robust expression of NOS2 has been linked to suppression of T cell proliferation and alterations in immune responses. Our studies investigated the hypothesis that the immunoprotective effect of CFA before immunization requires functional NOS2. NOS2 gene expression is chronically elevated in lymph
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Ratkay, L. G., L. Zhang, J. Tonzetich, and J. D. Waterfield. "Complete Freund's adjuvant induces an earlier and more severe arthritis in MRL-lpr mice." Journal of Immunology 151, no. 9 (1993): 5081–87. http://dx.doi.org/10.4049/jimmunol.151.9.5081.

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Abstract A study was performed on the effect of CFA on the spontaneous arthritis of MRL-lpr mice. The development of swelling and erythema was monitored for 1 mo after injecting 13- to 14-wk-old mice intradermally with CFA, at which time the histopathology of the joints and serologic responses to extracellular matrix proteins were investigated. In a series of six experiments, 67 to 82% of mice showed early clinical evidence of arthritis in contrast to the low percentage observed in control animals. Similarly, the histopathologic analyses on the CFA-injected mice indicated a significantly highe
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Kim, Ha-Neui, Yu-Ri Kim, Ji-Yeon Jang, Hwa-Kyoung Shin, and Byung-Tae Choi. "Electroacupuncture Confers Antinociceptive Effects via Inhibition of Glutamate Transporter Downregulation in Complete Freund's Adjuvant-Injected Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/643973.

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When we evaluated changes of glial fibrillary acidic protein (GFAP) and two glutamate transporter (GTs) by immunohistochemistry, expression of GFAP showed a significant increase in complete Freund's adjuvant (CFA)-injected rats; however, this expression was strongly inhibited by electroacupuncture (EA) stimulation. Robust downregulation of glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) was observed in CFA-injected rats; however, EA stimulation resulted in recovery of this expression. Double-labeling staining showed co-localization of a large proportion of GLAST or
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Kumar, Sanjai, Trevor R. Jones, Miranda S. Oakley, et al. "CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine." Infection and Immunity 72, no. 2 (2004): 949–57. http://dx.doi.org/10.1128/iai.72.2.949-957.2004.

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ABSTRACT Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expressed 19-kDa C-terminal region of merozoite surface protein 1 (yMSP119) of the murine malaria parasite Plasmodium yoelii. We found that in C57BL/6 mice, following sporozoite challenge, the degree of protective immunity against malaria induced by yMSP119 in a formulation of
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Olive, Colleen, Michael R. Batzloff, Anikó Horváth, et al. "A Lipid Core Peptide Construct Containing a Conserved Region Determinant of the Group A Streptococcal M Protein Elicits Heterologous Opsonic Antibodies." Infection and Immunity 70, no. 5 (2002): 2734–38. http://dx.doi.org/10.1128/iai.70.5.2734-2738.2002.

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ABSTRACT The study reported here investigated the immunogenicity and protective potential of a lipid core peptide (LCP) construct containing a conserved region determinant of M protein, defined as peptide J8. Parenteral immunization of mice with LCP-J8 led to the induction of high-titer serum immunoglobulin G J8-specific antibodies when the construct was coadministered with complete Freund's adjuvant (CFA) or administered alone. LCP-J8 in CFA had significantly enhanced immunogenicity compared with the monomeric peptide J8 given in CFA. Moreover, LCP-J8/CFA and LCP-J8 antisera opsonized four di
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Fang, Yuan, Thomas Rowe, Alberto J. Leon, et al. "Molecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus." Journal of Virology 84, no. 17 (2010): 8369–88. http://dx.doi.org/10.1128/jvi.02305-09.

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ABSTRACT The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG ODN-adjuvanted vaccine effectively increased antibody production and activated type I interferon (IFN) responses compared to vaccine alone. Based on these findings, pegylated IFN-α2b (PEG-IFN) was also evaluated as an adjuvant in comparison to CpG ODN and complete Freund's adjuvant (CFA).
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Widodo, Edwin, and Aulanni’am Aulanni’am. "SPECIFICITY OF ANTIBODY BOVINE ZONNA PELLUCIDAE 3 (ANTI-bZP3) TO RABBIT ZP3 BASED ON bZP3 AS CONTRACEPTIVE ANTIGENS." Indonesian Journal of Chemistry 5, no. 2 (2010): 182–87. http://dx.doi.org/10.22146/ijc.21829.

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Zonna pellucidae can be develop as antigen potential candidates based on reversible immunocontraceptive vaccines. Immunogenic sites of bovine zonna pellucidae 3 (bZP3) could stimulated the presence of anti-bZP3 which be located on rabbit ZP and inhibit sperm-egg interaction on fertilization process. Purpose of this research is to detect spesific binding anti-bZP3 to rabbit oocytes using dot blotting and ELISA method. Sub cutan induction of bZP3 with Freund's adjuvant, CFA (Complete Freund's Adjuvant) for initial immunization and following by IFA (Incomplete Freund's Adjuvant) at the 14th day a
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Dissertations / Theses on the topic "Complete Freund's adjuvant (CFA)"

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Oliveira, Patricia Gnieslaw de. "Efeito da administração do antagonista do receptor da bombesina/peptídeo liberador da gastrina RC-3095 na artrite induzida por CFA em ratos wistar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/12628.

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O peptídeo liberador da gastrina (GRP), homólogo mamífero da bombesina (BN), é um neuropeptídeo com múltiplas ações biológicas, incluindo um importante papel na regulação da resposta imunológica e inflamatória. Está presente em altas concentrações no líquido sinovial de pacientes com artrite reumatóide (AR), paralelamente com os níveis de interleucina-6 (IL-6) e fator de necrose tumoral (TNF). RC-3095 é um antagonista sintético do receptor da BN/GRP que demonstrou modular a liberação de citocinas pró-inflamatórias (TNF e IL-1 ) e diminuir o infiltrado inflamatório em modelos experimentais de s
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Silva, Morgana Duarte da. "Estudos comportamentais e farmacológicos com a diacereína no modelo de monoartrite induzida por adjuvante completo de freund (CFA) em ratos." Florianópolis, SC, 2009. http://repositorio.ufsc.br/xmlui/handle/123456789/92893.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.<br>Made available in DSpace on 2012-10-24T13:37:51Z (GMT). No. of bitstreams: 1 265366.pdf: 2761734 bytes, checksum: 0034f6e133cb9020706afbce0471d535 (MD5)<br>Osteoarthritis (OA) is the most prevalent form of rheumatic disease which affects joints like the knee, with pain as one of the most frequent symptoms among patients. Traditionally, drugs used for treatment of OA do not reduce joint damage, and have several side effects. A drug studied for this purpo
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Rosas, Ralph Fernando. "Avaliação dos efeitos da biocerâmica na inflamação periférica em camundongos : análise do mecanismo de ação." reponame:Repositório Institucional da UNISUL, 2017. http://www.riuni.unisul.br/handle/12345/4637.

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Introduction: Bioceramics have been studied for their ability to emit long infrared radiation producing non-thermal and thermal effects, with several biological activities. Objective: To evaluate the effects of bioceramics on peripheral inflammation in mice, as well as to analyze the possible neurobiological mechanism involved in this effect. Methods: Swiss male mice injected with CFA in the paw were submitted to bioceramic treatments by means of contact with a ceramic impregnated pad that, under paw heat, radiates far infrared. Six groups (n = 8) of animals were randomly distributed int
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Cruz, Timilly Mayra Martins da. "Avalia??o dos efeitos anti-inflamat?rio e antiedematog?nico do gel Oxyflower? em modelo de edema de pata em ratos." UFVJM, 2017. http://acervo.ufvjm.edu.br/jspui/handle/1/1723.

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?rea de concentra??o: Cl?nica Odontol?gica.<br>Linha de pesquisa: Les?es inflamat?rias, c?sticas e neopl?sicas da cavidade bucal.<br>Na Folha de Rosto e Ficha Catalogr?fica da obra consta o t?tulo: "Avalia??o dos efeitos anti-inflamat?rio e antiedematog?nico do gel Oxyflower? em modelo de edema de pata induzido por adjuvante completo de Freund em ratos".<br>Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-05-22T17:57:16Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) timilliy_mayra_martins_cruz.pdf: 1084452 bytes, checksum:
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Carroll, Christina. "The Treatment of Solid Tumours with Complete Freund's Adjuvant." Phd thesis, 2016. http://hdl.handle.net/1885/117235.

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Cancer immunotherapy, although being established over a century ago, is an emerging field in cancer treatment. The immune system contains multiple immune cell types which have been demonstrated to play complex roles in cancer development, progression, and elimination of tumour masses. This thesis describes the assessment of a novel potential cancer treatment, Complete Freund’s Adjuvant (CFA), which is injected intratumourally in an attempt to induce an anti-tumour immune response, leading to tumour regression. CFA has been used in research for decad
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Barszczyk, Andrew. "A Peptide Comprising the Src-interacting Domain of NADH Dehydrogenase Subunit 2 Alleviates Complete Freund's Adjuvant-induced Allodynia in Rats." Thesis, 2010. http://hdl.handle.net/1807/25421.

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Inflammatory and neuropathic pains arise in part from sensitization at nociceptive synapses in the spinal cord. Activity-dependent signaling cascades converge onto the tyrosine kinase Src, which participates in augmenting the function of N-methyl-D-aspartate receptors (NMDARs) and thus potentiates the nociceptive system. Src is capable of these effects because it is anchored to the NMDAR complex via an adaptor protein called NADH dehydrogenase subunit 2 (ND2). There is evidence that this interaction occurs between amino acids 40-49 of Src and amino acids 310-321 of ND2. I have determined that
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Books on the topic "Complete Freund's adjuvant (CFA)"

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Kohnert, Klaus-Dieter. Induction of beta cell necrosis by cumulative insults from complete Freund's adjuvant and low doses of streptozotocin. Studentlitteratur, 1991.

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Book chapters on the topic "Complete Freund's adjuvant (CFA)"

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"Complete Freund’s Adjuvant, CFA." In Encyclopedia of Immunotoxicology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-54596-2_100126.

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Conference papers on the topic "Complete Freund's adjuvant (CFA)"

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Roslida, A. H., M. B. Baizura, and K. Huzwah. "Acmella uliginosa (Sw) Cass. leaves extracts mitigate Complete-Freund Adjuvant (CFA) induced arthritis in rats via angiogenesis suppression." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736895.

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Kucikarova, Liubov, Khasan Kayumov, Sevara Berdiyorova, Rashid Achilov, Nurshat Murtazaeva, and Shokhlakhon Jurakulov. "The metabolic connection between diabetes mellitus and autoimmune hypothyroidism." In "Fiziologia şi sănătatea", congresul fiziologilor. Bulletin of the Academy of Sciences of Moldova. Medical Sciences, 2025. https://doi.org/10.52692/cfzl2024.30.

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It is supposed that there is a connection between diabetes mellitus (DM) and autoimmune hypothyroidism (AIH). The aim of this study was to compare some biochemical blood parameters in experimental DM and AIH. The experiments were carried out on outbred white rats. DM was induced by feeding animals with a high-fat diet and a single injection of streptozotocin (35 mg/kg). AIH was induced by three subcutaneous injections of thyroglobulin (100μ/rat) and Freund's adjuvant. For the first injection complete adjuvant, for the second and third treatments, incomplete adjuvant was used on the sixth and s
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Wernet, P., M. Haurand, W. Nüsing, E. M. Schneider, K. Jaschonek, and V. Ullrich. "Production and characterization of a murine monoclonal antibody against human thromboxane synthetase." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643382.

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Eicosanoids appear to have an important role in the actual momentary regulation of tissue blood flow. The function of constricting blood vessels by affecting the vascular tone has been assigned to thromboxane. Thromboxane synthetase, the enzyme responsible for the conversion of Prostaglandin-H2 into thromboxane A2, has been shown to be present in platelets, lung fibroblasts and the brain. Recently, thromboxane synthetase has been totally purified. The enzyme isolated from platelets appears to have a molecular weight of 58,800 Dalton and to belong to the group of cytochrome P450 proteins. In or
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