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Silva, Marcos Afonso da [UNESP]. "Análise complexa e aplicações." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153862.
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O objetivo principal deste trabalho é desenvolver um estudo introdutório, porém detalhado, sobre Análise Complexa e algumas de suas aplicações. Apresentamos o corpo dos números complexos, exploramos as funções complexas de uma variável complexa, exibimos parte da teoria das funções analíticas e parte da teoria de integração complexa. Provamos importantes resultados, tais como o Teorema de Cauchy, o Teorema de Taylor, o Teorema dos Resíduos, entre outros igualmente relevantes. Como aplicação da teoria, destacamos a utilização do Teorema dos Resíduos para determinar a transformada inversa de Laplace de uma função F(s).
The main objective of this work is to develop an introductory but detailed study on Complex Analysis and some of its applications. We present the field of the complex numbers, explore the complex functions of a complex variable, exhibit part of the theory of analytic functions, and part of the complex integration theory. We prove important results, such as Cauchy’s Theorem, Taylor’s Theorem, Residue Theorem, among others equally relevant. As an application of the theory, we highlight the use of the Residue Theorem to determine the inverse Laplace transform of a function F(s).
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Arnold, Rachel Florence. "Complex Analysis on Planar Cell Complexes." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32230.
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This paper is an examination of the theory of discrete complex analysis that arises from the
framework of a planar cell complex. Construction of this theory is largely integration-based.
A combination of two cell complexes, the double and its associated diamond complex, allows
for the development of a discrete Cauchy Integral Formula.Master of Science
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Al-Lawati, Nabila J. M. "Analysis of complex antibiotics." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/6af329d7-a44a-4c05-bd26-5664eddcbb1c.
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The emergence of multidrug resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii has been recognized worldwide and some clinical isolates of these bacteria are now resistant to most of the antibiotics currently available. Unfortunately, there are at present not enough new antimicrobial drugs being produced by the pharmaceutical industry to keep pace with the continuing development of antibiotic resistance. Colistin is an old antibiotic and in the form of colistin methanesulphonate sodium (CMS) has re-emerged as a major treatment for burn patients colonised with Acinetobacter baumannii. However, this antibiotic can lead to profound toxicity and for this reason the blood levels of CMS should be carefully monitored. Unfortunately the methods available for measuring it in serum are not robust and are not able to differentiate between the two forms of colistin i.e. colistin sulphate (CLS) and CMS. In this study the chemical (Thin Layer Chromatography and High Performance Liquid Chromatography) and microbiological methods for CLS and CMS analysis were investigated to develop a methodology for reproducible quantification of CLS and CMS in water or serum. Since CMS in aqueous solution has the potential to hydrolyze to produce a complex mixture of colistin sulphomethylated derivatives as well as colistin base, the optimized chemical and microbiological methods were used to determine the degradation of CLS or CMS in aqueous solution and serum. The bacteriostatic and bactericidal activity of CLS and CMS were probed by calculations of minimum inhibitory concentrations and time survivor studies. Depending on their concentrations, both antibiotics were found to exhibit bacteriostatic and bactericidal properties against a range of Gram-negative bacteria. Membrane damage caused by both forms of colistin was investigated using Acinetobacter lwoffii R46383 anddetennining intracellular potassium leakage and 260nm absorbing materials leakage. CLS was shown to cause substantial membrane damage, indicated by rapid, gross potassium leakage, while the effect of CMS on the membrane appeared to be more subtle, with cells exhibiting a more concentration dependent loss of potassium. Adsorption isotherms ofCLS gave results that were indicative of high affmity isotherm (H- shape), while adsorption isotherms of CMS were indicative of co-operative sorption (S- shape). Investigations into CLS and CMS cytotoxicity were performed using normal rat kidney (NRK-52E) cell line; the investigations revealed that neither forms of colistin has a major adverse effect on the rat renal cells even at concentrations higher than the therapeutic doses.
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Alotaibi, Abdullah Mathker. "Complex analysis using Nevanlinna theory." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/13793/.
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In this thesis, we mainly worked in the following areas: value distributions of meromorphic functions, normal families, Bank-Laine functions and complex oscillation theory. In the first chapter we will give an introduction to those areas and some related topics that are needed. In Chapter 2 we will prove that for a meromorphic function f and a positive integer k, the function af(f(k))n -1, n ≥ 2, has infinitely many zeros and then we will prove that it is still true when we replace f(k) by a differential polynomial. In Chapter 3 we will prove that for a merornorphic function f and a positive integer k, the function af f(k) -1 with N1(r, 1/f^((k)) ) = S(r, f) has infinitely many zeros and then we will prove that it is still true when we replace f(k) by a differential polynomial. In Chapter 4 we will apply Bloch's Principle to prove that a family of functions meromorphic on the unit disc B(0, 1), such that f(f1)m≠ 1, m ≠ 2, is normal. Also we will prove that a family of functions meromorphic on B(0,1), such that each f ≠ 0 and f(f(k))m ,k, m ∈N omits the value 1, is normal. In the fifth chapter we will generalise Theorem 5.1.1 for a sequence of distinct complex numbers instead of a sequence of real numbers. Also, we will get very nice new results on Bank-Laine functions and Bank-Laine sequences. In the last chapter we will work on the relationship between the order of growth of A and the exponent of convergence of the solutions y(k) +Ay =0, where A is a transcendental entire function with ρ(A) < 1/2.
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Boyer, Lee Christian. "Analysis of a Bap31 complex." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/MQ64325.pdf.
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Alexandersson, Per. "Combinatorial Methods in Complex Analysis." Doctoral thesis, Stockholms universitet, Matematiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-88808.
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The theme of this thesis is combinatorics, complex analysis and algebraic geometry. The thesis consists of six articles divided into four parts. Part A: Spectral properties of the Schrödinger equation This part consists of Papers I-II, where we study a univariate Schrödinger equation with a complex polynomial potential. We prove that the set of polynomial potentials that admit solutions to the Schrödingerequation is connected, under certain boundary conditions. We also study a similar result for even polynomial potentials, where a similar result is obtained. Part B: Graph monomials and sums of squares In this part, consisting of Paper III, we study natural bases for the space of homogeneous, symmetric and translation-invariant polynomials in terms of multigraphs. We find all multigraphs with at most six edges that give rise to non-negative polynomials, and which of these that can be expressed as a sum of squares. Such polynomials appear naturally in connection to expressing certain non-negative polynomials as sums of squares. Part C: Eigenvalue asymptotics of banded Toeplitz matrices This part consists of Papers IV-V. We give a new and generalized proof of a theorem by P. Schmidt and F. Spitzer concerning asymptotics of eigenvalues of Toeplitz matrices. We also generalize the notion of eigenvalues to rectangular matrices, and partially prove the a multivariate analogue of the above. Part D: Stretched Schur polynomials This part consists of Paper VI, where we give a combinatorial proof that certain sequences of skew Schur polynomials satisfy linear recurrences with polynomial coefficients.At the time of doctoral defence the following papers were unpublished and had a status as follows: Paper 5: Manuscript; Paper 6: Manuscript
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ARGENTO, CLAUDIO. "Complex networks: analysis and control." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/596.
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The introduction provides an overview on complex networks, trying to investigate what apparently different kinds of networks have in common. Some statistical properties are illustrated and a simulation tool for the analysis of complex networks is presented. A weighted directed random graph is used as network model. The graph contains a fixed number N of nodes and a variable number of edges: in particular, each edge is present with probability p. Some statistical properties (such as strong connection, global and local efficiency, cost, etc) are computed and their reliance on probability p is studied. Some probability distributions (such as shortest path, edge/node load) are also drawn and, by using the method of stages, the best fitting curves are computed. The way as parameters characterizing such curves change when p varies is also investigated. The general structure of the proposed fitting technique allows to model several aspects of complex networks and makes possible its use in many different fields. Finally, the tracking control problem of linear time invariant (LTI) systems when the plant and the controller belong to the same network is considered. Time delays can degrade significantly the performance of a networked control system, eventually leading to instability. The problem characterized by constant and known network delays is analytically examined, showing how to construct a plant state predictor in order to compensate the time delays between the plant and the controller, so to allow the tracking of a reference signal. Computer simulations illustrate the effectiveness of the proposed technique, also when time delays slightly vary around a mean value.
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Possamai, Lino <1978>. "Multidimensional analysis of complex networks." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5389/1/possamai_lino_tesi.pdf.
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Complex Networks analysis turn out to be a very promising field of research, testified by many research projects and works that span different fields. Those analysis have been usually focused on characterize a single aspect of the system and a study that considers many informative axes along with a network evolve is lacking.
We propose a new multidimensional analysis that is able to inspect networks in the two most important dimensions, space and time. To achieve this goal, we studied them singularly and investigated how the variation of the constituting parameters drives changes to the network as a whole.
By focusing on space dimension, we characterized spatial alteration in terms of abstraction levels. We proposed a novel algorithm that, by applying a fuzziness function, can reconstruct networks under different level of details. We verified that statistical indicators depend strongly on the granularity with which a system is described and on the class of networks.
We keep fixed the space axes and we isolated the dynamics behind networks evolution process.
We detected new instincts that trigger social networks utilization and spread the adoption of novel communities. We formalized this enhanced social network evolution by adopting special nodes (called sirens) that, thanks to their ability to attract new links, were able to construct efficient connection patterns. We simulated the dynamics of the system by considering three well-known growth models.
Applying this framework to real and synthetic networks, we showed that the sirens, even when used for a limited time span, effectively shrink the time needed to get a network in mature state. In order to provide a concrete context of our findings, we formalized the cost of setting up such enhancement and provided the best combinations of system's parameters, such as number of sirens, time span of utilization and attractiveness.
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Possamai, Lino <1978>. "Multidimensional analysis of complex networks." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5389/.
Full textAbstract:
Complex Networks analysis turn out to be a very promising field of research, testified by many research projects and works that span different fields. Those analysis have been usually focused on characterize a single aspect of the system and a study that considers many informative axes along with a network evolve is lacking.
We propose a new multidimensional analysis that is able to inspect networks in the two most important dimensions, space and time. To achieve this goal, we studied them singularly and investigated how the variation of the constituting parameters drives changes to the network as a whole.
By focusing on space dimension, we characterized spatial alteration in terms of abstraction levels. We proposed a novel algorithm that, by applying a fuzziness function, can reconstruct networks under different level of details. We verified that statistical indicators depend strongly on the granularity with which a system is described and on the class of networks.
We keep fixed the space axes and we isolated the dynamics behind networks evolution process.
We detected new instincts that trigger social networks utilization and spread the adoption of novel communities. We formalized this enhanced social network evolution by adopting special nodes (called sirens) that, thanks to their ability to attract new links, were able to construct efficient connection patterns. We simulated the dynamics of the system by considering three well-known growth models.
Applying this framework to real and synthetic networks, we showed that the sirens, even when used for a limited time span, effectively shrink the time needed to get a network in mature state. In order to provide a concrete context of our findings, we formalized the cost of setting up such enhancement and provided the best combinations of system's parameters, such as number of sirens, time span of utilization and attractiveness.
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Memon, Sohail Ahmed. "Mathematical modelling of complex dynamics." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20497/.
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Soft materials have a wide range of applications, which include the production of masks for nano–lithography, the separation of membranes with nano–pores, and the preparation of nano–size structures for electronic devices. Self–organization in soft matter is a primary mechanism for the formation of structure. Block copolymers are long chain molecules composed of several different polymer blocks covalently bonded into a single macromolecule, which belong to an important class of soft materials which can self–assemble into different nano–structures due to their natural ability to microphase separate. Experimental and theoretical studies of block copolymers are quite challenging and, without computer simulations, it is difficult and problematic to analyse modern experiments. The Cell Dynamics Simulation (CDS) technique is a fast and accurate computational technique, which has been used to investigate block copolymers. The stability has been analysed by making use of different discrete Laplacian operators using well–chosen time steps in CDS. This analysis offers stability conditions for phase–field, based on the Cahn–Hilliard Cook (CHC) equations of which CDS is the finite difference approximation. To overcome grid related artefacts (discretization errors) in the computational grid, the study has been done for employing an isotropic Laplacian operator in the CDS framework. Several 2D and 3D discrete Laplacians have been quantitatively compared for their isotropy. The novel 2D 9–point BV(D2Q9) isotropic stencil operators have been derived from the B.A.C. van Vlimmeren method and their isotropy measure has been determined optimally better than other exiting 2D 9–point discrete Laplacian operators. Overall, the stencils in 9–point family Laplacians in 2D and the 19–point stencil operators in 3D have been found to be optimal in terms of isotropy and time step stability. Considerable implementation of Laplacians with good isotropy has played an important role in achieving a proper structure factor in modelling methods of block copolymers. The novel models have been developed by implementing CDS via more stable implicit methods, including backward Euler, Crank–Nicolson (CN) and Alternating Direction Implicit (ADI) methods. The CN scheme were implemented for both one order and two order parameter systems in CDS and successful results were obtained compared to forward Euler method. Due to the implementation of implicit methods, the CDS has achieved second–order accuracy both in time and space and it has become stronger, robust and more stable technique for simulation of the phase–separation phenomena in soft materials.
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Zymonopoulou, Maria-Isavella. "Sections of complex convex bodies." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5528.
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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on June 18, 2009) Vita. Includes bibliographical references.
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Bui, Quang Vu. "Pretopology and Topic Modeling for Complex Systems Analysis : Application on Document Classification and Complex Network Analysis." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEP034/document.
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Les travaux de cette thèse présentent le développement d'algorithmes de classification de documents d'une part, ou d'analyse de réseaux complexes d'autre part, en s'appuyant sur la prétopologie, une théorie qui modélise le concept de proximité. Le premier travail développe un cadre pour la classification de documents en combinant une approche de topicmodeling et la prétopologie. Notre contribution propose d'utiliser des distributions de sujets extraites à partir d'un traitement topic-modeling comme entrées pour des méthodes de classification. Dans cette approche, nous avons étudié deux aspects : déterminer une distance adaptée entre documents en étudiant la pertinence des mesures probabilistes et des mesures vectorielles, et effet réaliser des regroupements selon plusieurs critères en utilisant une pseudo-distance définie à partir de la prétopologie. Le deuxième travail introduit un cadre général de modélisation des Réseaux Complexes en développant une reformulation de la prétopologie stochastique, il propose également un modèle prétopologique de cascade d'informations comme modèle général de diffusion. De plus, nous avons proposé un modèle agent, Textual-ABM, pour analyser des réseaux complexes dynamiques associés à des informations textuelles en utilisant un modèle auteur-sujet et nous avons introduit le Textual-Homo-IC, un modèle de cascade indépendant de la ressemblance, dans lequel l'homophilie est fondée sur du contenu textuel obtenu par un topic-modelThe work of this thesis presents the development of algorithms for document classification on the one hand, or complex network analysis on the other hand, based on pretopology, a theory that models the concept of proximity. The first work develops a framework for document clustering by combining Topic Modeling and Pretopology. Our contribution proposes using topic distributions extracted from topic modeling treatment as input for classification methods. In this approach, we investigated two aspects: determine an appropriate distance between documents by studying the relevance of Probabilistic-Based and Vector-Based Measurements and effect groupings according to several criteria using a pseudo-distance defined from pretopology. The second work introduces a general framework for modeling Complex Networks by developing a reformulation of stochastic pretopology and proposes Pretopology Cascade Model as a general model for information diffusion. In addition, we proposed an agent-based model, Textual-ABM, to analyze complex dynamic networks associated with textual information using author-topic model and introduced Textual-Homo-IC, an independent cascade model of the resemblance, in which homophily is measured based on textual content obtained by utilizing Topic Modeling
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Gontard, Sébastien. "Courbures de métriques invariantes dans les variétés complexes non compactes." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAM027/document.
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Nous étudions les relations entre des propriétés géométriques et des propriétés métriques dans les domaines de C^n.Plus précisément, nous nous intéressons au comportement des courbures bisectionnelles holomorphes de métriques de Kähler invariantes, la métrique de Bergman et la métrique de Kähler-Einstein, au voisinage du bord des domaines pseudoconvexe bornés à bord lisse.Nous prouvons qu'aux points de stricte pseudoconvexité ou tels que la fonction squeezing du domaine tend vers 1 les courbures bisectionnelles holomorphes de la métrique de Kähler-Einstein du domaine tendent vers les courbures bisectionnelles holomorphes de la métrique de Kähler-Einstein de la boule.Nous étudions également les courbures de la métrique de Kähler-Einstein et de la métrique de Bergman dans certains domaines polynomiaux (notamment les domaines tubes et les domaines de Thullen de C^2) qui servent de modèles locaux aux points du bord qui sont de type fini. A partir de ces études nous prouvons qu'en certains points du bord de domaines convexes bornés lisse de type fini dans C^2 il existe un voisinage non tangentiel tel que les courbures bisectionnelles holomorphes de la métrique de Kâhler-Einstein sont pincées négativement. Nous prouvons également que pour tout domaine pseudoconvexe borné de type fini qui est Reinhardt complet il existe un voisinage du bord relatif au domaine tel que les courbures bisectionnelles holomorphes de la métrique de Bergman sont comprises entre deux constantes strictement négativesWe study the relationships between geometric properties and metric properties of domains in C^n.More precisely, we are interested in the behavior of holomorphic bisectional curvatures of invariant Kähler metrics, namely the Bergman metric and the Kähler-Einstein metric, near the boundary of bounded pseudoconvex domains with smooth boundary.We prove that at boundary points that are either strictly pseudoconvex or such that the squeezing function of the domain tends to one the holomorphic bisectional curvatures of the Kähler-Einstein metric of the domain tends to the holomorphic bisectional curvatures of the Kähler-Einstein metric of the ball.We also study the holomorphic bisectional curvatures of the Kähler-Einstein metric and of the Bergman metric in some polynomial domains (namely tube and Thullen domains in C^2) which serve as local models at boundary point of finite type. Using these studies we prove that at certain boundary points of smoothly bounded convex domains of finite type there exists a non tangential neighbourhood such the holomorphic bisectional curvatures of the Kähler-Einstein metric are pinched between two negative constants. We also prove that for every smoothly bounded pseudoconvex complete Reinhardt domain of finite type inf C^2 there exists a neighbourhood of the boundary relative to the domain in which the holomorphic bisectional curvatures of the Bergman metric are pinched between two negative constants
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McQuaid, Michael James. "Spectroscopic characterization of metal-based complexes and metal-based complex oxidation processes." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/30334.
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Lashgari, Iman. "Global stability analysis of complex fluids." Licentiate thesis, KTH, Mekanik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-139405.
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The main focus of this work is on the non-Newtonian effects on the inertial instabilities in shear flows. Both inelastic (Carreau) and elastic models (Oldroyd-B and FENE-P) have been employed to examine the main features of the non-Newtonian fluids; shear-thinning, shear-thickening and elasticity. Several classical configurations have been considered; flow past a circular cylinder, in a lid-driven cavity and in a channel. We have used a wide range of tools for linear stability analysis, modal, non-modal, energy and sensitivity analysis, to determine the instability mechanisms of the non-Newtonian flows and compare them with those of the Newtonian flows. Direct numerical simulations have been also used to prove the results obtained by the linear stability analysis. Significant modifications/alterations in the instability of the different flows have been observed under the action of the non-Newtonian effects. In general, shear-thinning/shear-thickening effects destabilize/stabilize the flow around the cylinder and in a lid driven cavity. Viscoelastic effects both stabilize and destabilize the channel flow depending on the ratio between the viscoelastic and flow time scales. The instability mechanism is just slightly modified in the cylinder flow whereas new instability mechanisms arise in the lid-driven cavity flow. We observe that the non-Newtonian effect can alter the inertial flow at both baseflow and perturbation level (e.g. Carreau fluid past a cylinder or in a lid driven cavity) or it may just affect the perturbations (e.g. Oldroyd-B fluid in channel). In all the flow cases studied, the modifications in the instability dynamics are shown to be strongly connected to the contribution of the different terms in the perturbation kinetic energy budget.QC 20140113
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Belinschi, Serban Teodor. "Complex analysis methods in noncommutative probability." [Bloomington, Ind.] : Indiana University, 2005. http://wwwlib.umi.com/dissertations/fullcit/3182615.
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Thesis (Ph.D.)--Indiana University, Dept. of Mathematics, 2005.Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3738. Adviser: Hari Bercovici. Title from dissertation home page (viewed Oct. 5, 2006).
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Kim, Yushim. "Analysis for adaptive complex public enterprises." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164742628.
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Mannan, Sabira Khanam. "The visual analysis of complex scenes." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321654.
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Klapper, Jennifer Helen. "Data analysis with complex Daubechies wavelets." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634529.
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Wavelet thresholding is an increasingly popular method of nonparametric smoothing. Both real-valued and complex-valued Daubechies wavelets exist. However, to date, complex-valued wavelets have attracted little attention in the statistical literature compared to real-valued wavelets. The broad aim of this thesis is to further the application of complex-valued Daubechies wavelets within the wavelet thresholding framework. Much of the previous work that applied complex-valued wavelets focused upon their application to real-valued data. However, complex-valued data exist and arise in multiple scientific areas. This thesis firstly examines how one method of applying complex-valued wavelets performs on complex-valued data before modifying the methodology to allow for native denoising of complex-valued data. A large number of smoothing regimes exist within the wavelet framework, known as 'thresholding rules'. The majority of these thresholding rules have been designed for use in conjunction with real-valued wavelets. One such thresholding rule is known as 'block thresholding' whereby the data is considered in blocks, rather than as individual data points, to allow for correlation between neighbouring data points. A further thresholding method is known as the 'fiducial thresholding' method which attempts to circumvent perceived problems within the Bayesian approach. Within this thesis these two thresholding rules are developed to allow for the application of complex-valued wavelets; the difference in their performance when using real- and complex-valued wavelets is investigated by simulation.
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SILVA, WILSON FERREIRA DA. "ANALYSIS OF COMPLEX SECTION WIRE ROPES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 1996. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=19738@1.
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A análise teórica de cabos de aço é bastante complexa. Durante anos, muitos tipos de cabos de aço têm sido testados experimentalmente para as mais diversas aplicações. No início dos anos 70, foi desenvolvido por Costello, um modelo teórico para prever as tensões de contacto entre os arames de uma perna de um cabo de aço. A partir deste modelo teórico, que possibilitou o estabelecimento das equações de equilíbrio de cada elemento do cabo, diversos trabalhos foram desenvolvidos na tentativa de solucionar as equações de cabos. Este sistema de equações é não linear e deve ser resolvido numericamente para os casos genéricos. Em 1994, uma aproximação linear para estas equações foi desenvolvida por Velinsky. Estas equações lineares de equilíbrio de cabos foram posteriormente generalizadas para geometrias e construções complexas.
Este trabalho apresenta o desenvolvimento de um programa para análise de cabos de aço de geometria complexa. O trabalho inicialmente apresenta o estudo das deformações de um arame helicoidal. Diversos destes arames formam as pernas, que enrolados posteriormente produzirão os cabos de aço. As deformações do cabo de aço são estudadas a partir da deformação individual de cada uma das pernas que o constituem. O programa desenvolvido neste trabalho considera o comportamento de cabos de aço composto por qualquer número de pernas (estas com qualquer número de arames). Estes cabos de aço podem ainda ter ou não núcleo interno. Os algoritmos utilizados pelo programa baseiam-se nas equações desenvolvido por Phillips e Costello em 1993. Os resultados obtidos por este programa são comparados com diversos resultados experimentais e numéricos disponíveis na literatura. O programa se mostrou capaz de simular o comportamento em cabos de construção complexa. Carregamentos compostos pela combinação de tração, com torção e flexão e ainda o efeito da passagem do cabo por roldanas e tambores de enrolamento em guindastes foram testados. As tensões e deformações obtidas nas mais diversas geometria de cabos com ou sem núcleo interno mostraram excelente concordância em todas as comparações feitas.The theorical analysis of wine rope is rather complex. Over the years, may types of wine rope have been tested experimentally for various applications. In the early 1970, Costello developed a theorical model to predict the contact stress in the individual wires of a strand. This model led to a series of papers on the solution of their equations of equilibrium. These equations are highly nonlinear and must be solved numerically on the computer. Approximate linear equations have been derived by Velinsky et al (1994), and generealized for any kind of wire rope by others. This work shows the development and results of a computer program that has been developed to analyze complex cables. The analysis of a rope begins with a study of the deformation of a helical wire in a strand. By the deformation of all wires in a given strand, one determines the response of that strand. Again by the deformation of all strands in the rope, one determines the response of a rope. The program developed treats in a realistic manner the deformation and stress of ropes having or not internal-wire-ropes cores. The algorithms is built around the original nonlinear equation of Philips and Costello (1993). Numerical results is presented and compared with the experiments reports in the literature. The program is capable of simulating bahavior in various situations and complex constructions for rope loaded in tension with twisting and bending over a sheave or drum. The stress and strain of diferents wire ropes habving an internal-wire-rope core (IWRC) are obtained eficiently in all experiments. The results show that the presented implementation produce minimum variation between the theory or the expected results. Results may be extended to include other consideration of rope behavior as contact stress and friction effect.
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Ward, Sean. "Differential chemometric analysis of complex mixtures." Thesis, University of Huddersfield, 2018. http://eprints.hud.ac.uk/id/eprint/34511/.
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The following thesis used chemometric software to examine data generated from differential analysis of complex mixtures. Three different chemometric projects were investigated along with the comparison of two different chemometric software packages. 1. Liquid chromatography linked with mass spectrometry (LC-MS) was used to analyse gelatin from different species of animals. Using Agilent Technologies MPP chemometric software to analyse the data it was possible to find peptide fragments that were specific to each species of gelatin. Identification of these peptides was very difficult due to the destructive nature of gelatin manufacture. The method developed in this thesis allowed identification of 21 unknown gelatin samples with 100% accuracy. 2. Whiskey samples that had been matured in either American or Spanish oak barrels, and sampled over 22 years were analysed by LC-MS, the data was analysed with Agilent’s MPP chemometric software and the differences between the two wood types evaluated. Out of the compounds discovered to differentiate the whiskey from the different wood types two were identified as Gallic and Ellagic acid. These two compounds could be used to determine the wood type, a particular year of whiskey, or years of maturation for a whiskey matured in a particular wood type. The data generated for Whiskey maturity was also analysed using Waters Progenesis software and a comparison of the discovered compounds drawn. This highlighted an issue with incorrect assignment of neutral masses by MPP software. The data extraction method used by Progenesis was also found to be much less labour intensive than data extraction with MPP. 3. MPP was used to compare LC-MS data generated from the blood plasma of people suffering with multiple sclerosis with an age and gender matched control group. This was an un-targeted approach which led to the discovery of two compounds, Sphingosine and Dihydrosphingosine that were found to be lower in the blood of people suffering from multiple sclerosis. These compounds were searched in a larger sample set and found to follow the same trend of being lower in the disease group. It may be possible to use the concentration of these compounds in the blood as a marker of the disease.
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Teki, S. "Cognitive analysis of complex acoustic scenes." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1413017/.
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Natural auditory scenes consist of a rich variety of temporally overlapping sounds that originate from multiple sources and locations and are characterized by distinct acoustic features. It is an important biological task to analyze such complex scenes and extract sounds of interest. The thesis addresses this question, also known as the “cocktail party problem” by developing an approach based on analysis of a novel stochastic signal contrary to deterministic narrowband signals used in previous work. This low-level signal, known as the Stochastic Figure-Ground (SFG) stimulus captures the spectrotemporal complexity of natural sound scenes and enables parametric control of stimulus features. In a series of experiments based on this stimulus, I have investigated specific behavioural and neural correlates of human auditory figure-ground segregation. This thesis is presented in seven sections. Chapter 1 reviews key aspects of auditory processing and existing models of auditory segregation. Chapter 2 presents the principles of the techniques used including psychophysics, modeling, functional Magnetic Resonance Imaging (fMRI) and Magnetoencephalography (MEG). Experimental work is presented in the following chapters and covers figure-ground segregation behaviour (Chapter 3), modeling of the SFG stimulus based on a temporal coherence model of auditory perceptual organization (Chapter 4), analysis of brain activity related to detection of salient targets in the SFG stimulus using fMRI (Chapter 5), and MEG respectively (Chapter 6). Finally, Chapter 7 concludes with a general discussion of the results and future directions for research. Overall, this body of work emphasizes the use of stochastic signals for auditory scene analysis and demonstrates an automatic, highly robust segregation mechanism in the auditory system that is sensitive to temporal correlations across frequency channels.
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Maidstone, Robert. "Efficient analysis of complex changepoint problems." Thesis, Lancaster University, 2016. http://eprints.lancs.ac.uk/83055/.
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Many time series experience abrupt changes in structure. Detecting where these changes in structure, or changepoints, occur is required for effective modelling of the data. In this thesis we explore the common approaches used for detecting changepoints. We focus in particular on techniques which can be formulated in terms of minimising a cost over segmentations and solved exactly using a class of dynamic programming algorithms. Often implementations of these dynamic programming methods have a computational cost which scales poorly with the length of the time series. Recently pruning ideas have been suggested that can speed up the dynamic programming algorithms, whilst still being guaranteed to be optimal. In this thesis we extend these methods. First we develop two new algorithms for segmenting piecewise constant data: FPOP and SNIP. We evaluate them against other methods in the literature. We then move on to develop the method OPPL for detecting changes in data subject to fitting a continuous piecewise linear model. We evaluate it against similar methods. We finally extend the OPPL method to deal with penalties that depend on the segment length.
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KING-NYGREN, ELIAS. "Analysis of Complex 3D-Concrete Casting." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299789.
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Concrete is the second most used material in the world and is primarily used within the construction industry. It is however also used for making decorative and functional smaller products within various industries. Manufacturing with concrete can be done with different manufacturing techniques, the most common technique being concrete casting in molds. This project was conducted at Arclight AB in Stockholm, a company on the verge of starting production of molds for casting concrete products. With many different manufacturing techniques at their disposal, it is however difficult for them to know which manufacturing technique should be used for which type of mold. The goal of this project is to compare the available manufacturing techniques at Arclight and see which are most suitable for mold manufacturing. The background research and preparation resulted in three segments of the casting process which needed to be analyzed: choice of concrete, choice post-processing technique, and choice of manufacturing technique. Results from the trails of these three segments gave invaluable information for the project. Concrete trails resulted in a recommendation of a concrete with high compression strength and high water content to make the concrete viscous and flow easily into the mold. Post-processing trials resulted in different optimal post-processing techniques based on the mold material and manufacturing technique. Manufacturing trails gave in-depth information on processing larger molds and the potential problems associated with casting complex large concrete products. The final result of the project is a spreadsheet which recommends an optimal manufacturing technique based on the geometry type and number of products to be cast. Maximum cost per product, maximum machine time for manufacturing and maximum total production time for the concrete products are also stated to find the optimal manufacturing technique for each specific concrete casting project. Before using this spreadsheet as a basis for manufacturing, it should be formatted for easier use. Additional tests with applying epoxy and polyurethane resin for post-processing molds should be conducted, in addition to testing materials for manufacture of master molds for vacuum forming.Betong är det näst mest använda råmaterialet i världen och används primärt inom byggindustrin. Det används även för tillverkning av estetiska och funktionella mindre produkter inom andra industrier. Betongprodukter kan tillverkas med flera olika tillverkningstekniker, där den vanligaste är gjutning av betong i gjutformar. Detta projekt var utfört hos Arclight AB i Stockholm, ett företag som är i början av att starta produktion av gjutformar för gjutning av betongprodukter. Med så många olika tillverkningstekniker hos företaget är det svårt att veta vilken tillverkningsteknik som är bäst lämpad för vilken typ av gjutform. Målet med detta projekt är att jämföra de olika tillverkningstekniker Arclight har och se vilka är mest lämpade för tillverkning av gjutformar. Bakgrundsforskningen och förberedandet resulterade i tre segment av gjutprocessen som behövde analyseras; val av betong, val av ytbehandlingsteknik, och val av tillverkningsteknik. Testerna inom dessa tre segment gav ovärderlig information för projektet. Resultatet av betongtesterna var en rekommendation av betong med hög tryckhållfasthet och en stor mängd vatten i betongen för lättare hällning i gjutformen. Resultatet av ytbehandlingstesterna var olika optimala ytbehandlingar beroende på material för gjutformen, samt tillverkningsteknik. Resultatet av tillverkningstesterna gav information om stora gjutformar bäst hanteras och eventuella problem associerade med att gjuta stora komplexa betongprodukter. Slutgiltiga resultatet av projektet är ett kalkylblad vilket rekommenderar optimala tillverkningsmetoden baserat på geometritypen av produkten som ska gjutas samt antalet produkter att tillverka. Maximal kostnad per produkt, maximal maskintid för tillverkning och maximal total tillverkningstid för produktion av betongprodukterna bestäms även för att finna optimala tillverkningstekniken för varje specifikt betonggjutningsprojekt. Innan detta kalkylark används för tillverkning borde det formateras så det är mer användarvänligt. Ytterligare ytbehandlingstester med epoxyresin och polyuretanresin bör göras på gjutformar, samt även att testa material för tillverkning av formverktyg för vakumforming.
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Panizza, M. P. "Analysis of complex integral photoelectron spectra /." Title page, contents and introduction only, 1985. http://web4.library.adelaide.edu.au/theses/09SM/09smp193.pdf.
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Silva, Jonathan Cardoso. "Optimisation-based methodologies for complex data analysis." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/optimisationbased-methodologies-for-complex-data-analysis(7ef64e5c-f9ef-44e7-804a-a21ec25dd007).html.
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Networks are a natural representation of data collected across many disciplines. The complex relationships between entities studied in these fields, whether it be people, computers or molecules, cannot be fully characterised individually but are, instead, better described by computational models as a function of their overall interactions. This thesis focuses on the development of such models to detect communities and to predict outcome variables in real networks using mathematical programming, a transparent, flexible and customisable modelling paradigm. First, the temporal evolution of groups in complex social networks is explored. Various methods detect groups in dynamic networks either by aggregating all temporal contact information into a single network or by looking at snapshots of time independently. In this work, a more robust approach is employed where, at each time step, both the current and previous modular structures of a network are considered. A mixed integer non-linear programming (MINLP) model is proposed to capture more stable patterns of change and was shown to match the ground truth of networks. Next, the development of Quantitative Structure-Activity Relationship models (QSAR) is addressed. These regression models are vastly used in drug discovery and aim to predict biological activity from the attributes of molecules. In this work, algorithms are proposed to divide the compounds in sub-groups either by their molecular features or from modules that naturally arise when representing this data as a network. Suitable equations that predict biological activity are then identified for each group by a mathematical programming model. These algorithms create predictive, customisable and interpretable QSAR sub-models, which can later be used for virtual screening, SAR studies or lead optimisation of drug candidates. Overall, this thesis proposes computational models to optimisation problems in regression and network analysis. The proposed methods produce transparent and interpretable solutions towards a better understanding of the dynamics of social systems and have the potential to assist in the endeavours of drug discovery.
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Rentergent, Julius. "Time course analysis of complex enzyme systems." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/time-course-analysis-of-complex-enzyme-systems(1c44f0cf-188d-4cd7-ab2d-012da27646a8).html.
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In studies of enzyme kinetics, reaction time courses are often condensed into a single set of initial rates describing the rate at the start of the reaction. This set is then analysed with the Henri-Michaelis-Menten equation. However, this process necessarily removes information from experimental data and diminishes its statistical significance due to a reduction of available data points. Further, if the examined system does not approach steady-state rapidly, the application of the steady-state-assumption can lead to flawed conclusions. Here, the analysis of two complex enzyme systems by numerical integration of kinetic rate equations is demonstrated. DNA polymerase catalyses the synthesis of DNA in a reaction that involves two substrates, DNA template and dNTP, both of which are highly heterogeneous in nature. The tight binding of DNA to DNA polymerase and its polymer properties prohibit the application of the initial-rate approach. By combining an explicit DNA binding step with a steady-state dNTP incorporation on a template of finite length, the DNA binding parameters and the dNTP incorporation steady-state parameters were estimated from processive polymerisation data in a global regression analysis. This approach is described in Chapter 2 and the results are in good agreement with previously published values. Further properties were investigated in studies of the temperature dependence and solvent isotope dependence of the kinetics. The processive polymerisation of DNA template was monitored using the fluorophore PicoGreen in a simple and inexpensive method described in Chapter 3. The catalytic cycle of ethanolamine ammonia lyase involves the homoloysis of the Co-C bond within the intrinsic B12 cofactor. This homolysis results in the formation of a Co(II)-adenosyl radical intermediate, which can be monitored using stopped-flow spectroscopy. The stopped-flow transients observed for EAL and related enzymes have long been difficult to analyse and interpret, possibly due to rapid methyl group rotation on the substrate. In Chapter 4 of this thesis we were able to rationalise this behaviour using numerical integration of the rate equations of a branched 16-state-kinetic model to fit stopped-flow transients in a global regression analysis. We were able to determine some intrinsic rate constants, and showed that the initial hydrogen atom transfer step is unlikely to have an inflated primary kinetic isotope effect, despite previous claims. More generally, this study demonstrates that the numerical integration analysis used here is likely to be applicable to a broad range of enzyme reaction kinetics.
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Sadykov, Timour. "Hypergeometric functions in several complex variables." Doctoral thesis, Stockholm : Univ, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-198.
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da, Silva Dilma Menezes. "A framework for building complex systems." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/9229.
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Krapez, Marion. "Spreading of complex fluids : deposition laws and analysis of spreading defects." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS076.
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L'étalement de fluides complexes est un processus clé dans l'industrie. Les exemples classiques sont le la pose d’enduit ou de peinture, l'application de crème et de maquillage et la fabrication de papier. Dans toutes ces situations, les fluides sont non-newtoniens en raison de la présence de polymères et/ou de particules, ce qui induit un comportement rhéologique complexe. En nous concentrant sur les applications cosmétiques, nous avons cherché à comprendre comment les propriétés du fluide impactent le film déposé.Dans une première partie, nous avons considéré l’étalement de solutions de polymères avec une lame flexible qui se déforme pendant l’étalement. Ces expériences ont été combinées avec des modèles numériques et des lois d'échelles. Nous montrons que l’épaisseur du film déposé diminue lorsque le réservoir de fluide se vide menant à des dépôts inhomogènes en épaisseur. En utilisant des fluides newtoniens et complexes aux propriétés rhéologiques bien choisies, nous avons caractérisé les effets de la viscosité, du caractère rhéofluidifiant, et des contraintes normales sur les caractéristiques du film déposé et du processus d’étalement. Ainsi en jouant sur les propriétés rhéologiques du fluide les dépôts peuvent être plus ou moins homogènes. Nous révélons également deux résultats contre-intuitifs : il faut plus d'énergie pour étaler un même volume en un même temps avec un fluide rhéofluidifiant qu’avec un fluide Newtonien. Deuxièmement, les contraintes normales, qui conduisent habituellement à des comportements remarquables, ont ici un effet négligeable en raison de la géométrie d’étalement. Avec les fluides à seuil, des phénomènes parasites associés au seuil rendent les dépôts moins prédictibles.Dans une deuxième partie, nous avons étudié les défauts d’étalement en se concentrant sur la formation d’agrégats apparaissant parfois lors de l’étalement d’une formulation après séchage sur la peau. Nous avons identifié les paramètres de formulation et d’étalement qui impactent l’apparition de ces défauts, et nous proposons un modèle basé sur la cohésion et l’adhésion. Enfin, nous proposons un critère à respecter pour limiter leur occurrenceThe spreading of complex fluids is a key process in the industry. Classic examples are the coating of paint or protective layer, cream and make-up application on the skin, and the fabrication of paper. In all these situations, the fluids are non-Newtonian due to the presence of polymers or/and particles, resulting in more complex rheological behavior under shear. Focusing on cosmetic applications, we sought to understand how the fluid properties impact the deposited film.In the first part, we considered the spreading of polymer solutions with a flexible blade that deforms during spreading. We combined these experiments with numerical models and scaling laws. We show that the thickness of the deposited film decreases as the fluid reservoir empties leading to inhomogeneous deposits in thickness. Using Newtonian and complex fluids with well-chosen rheological properties we disentangled the effects of shear viscosity, shear-thinning, and normal stresses over the characteristics of the deposited film and the coating process. Thus, by playing on the rheological properties of the fluid, the deposits can be more or less homogeneous. We reveal two counterintuitive results: it takes more energy to spread a volume of shear-thinning fluid than a volume of a Newtonian fluid in a given time. Second, the normal stresses, which usually lead to remarkable behaviors have a strikingly negligible effect here due to the coating geometry. With yield stress fluids, specific phenomena associated with the yield make the deposits less predictable.In the second part, we studied spreading defects by focusing on the formation of aggregates, which sometimes appear during the spreading of a formulation after drying on the skin. We identified the formulation and spreading parameters that influence the development of these defects, and propose a model based on cohesion and adhesion. Finally, we suggest a criterion to limit their occurrence
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McGoverin, Cushla Maree, and n/a. "Raman spectroscopy of complex mixtures." University of Otago. Department of Chemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081103.112612.
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This thesis presents several Raman spectroscopic studies of bovine milk-derived products (skim and whole milk powder, anhydrous milk fat, processed cheese and soy cheese made from milk protein). Raman spectroscopy, unlike infrared spectroscopy (both mid- and near-infrared), has not been widely used as an analytical tool within the dairy industry. The purpose of this project was to assess the utility of Raman spectroscopy in several dairy industry relevant problems. FT-Raman spectroscopy coupled with partial least squares (PLS) reliably predicted the concentration of fat and protein within whole milk and protein within skim milk powders as evidenced by ratios of prediction to deviation in excess of three. It was shown that sample geometry did not significantly affect the calculated predictive models, thereby allowing the simplest, quickest method of sample presentation to be utilised without harming quantification model efficacy.
The fat fraction of milk was further investigated, and it was shown that Raman spectra collected from anhydrous milk fat samples were a good basis for solid fat content (SFC) determination. Such spectra were collected when the samples were held at 40 �C, pretreated by baselining and area normalisation, and analysed using PLS with modified jack-knifing (PLS1-JK). Triacylglycerol class concentrations were also well predicted by PLS1-JK models developed from Raman spectroscopic data. Resonance enhancement of β-carotene within fat was shown to have little effect on the reliability of the optimal prediction model when compared to SFC Raman quantification.
Raman microscopic mapping for heterogeneity description of processed cheese and soy cheese mimics was examined. The FT-Raman milk powder constituents study had shown fat and protein Raman spectra within complex dairy mixtures could be distinguished, hence this utility was applied to mapping of cheese systems. Univariate, principal components analysis and multivariate curve resolution methods of analyses were compared; as expected the more complex samples required multivariate methods of analyses. Raman microscopic mapping was not a time efficient method in comparison to the standard method of confocal laser scanning microscopy. However, Raman spectroscopic mapping is a more universal technique which allowed the presence of an unexpected localised constituent within the soy cheese mimics to be observed. It was proposed that this constituent was a crystalline form of a short saturated fatty acid.
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Sabourova, Natalia. "Real and complex operator norms." Licentiate thesis, Luleå : Luleå University of Technology, 2007. http://epubl.luth.se/1402-1757/2007/09.
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Aljure, Osorio David Eduardo. "Aerodynamic analysis of complex geometries using CFD." Doctoral thesis, Universitat Politècnica de Catalunya, 2017. http://hdl.handle.net/10803/454977.
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Aerodynamic analysis has become one of the most important tools in many engineering applications. In this sense, this thesis work is aimed at performing aerodynamic analysis of different geometries, expanding the available knowledge and obtaining valuable insight from the obtained results. Aerodynamic analysis can be carried out, principally, in two ways: Experimental research and Computational Fluid Dynamics (CFD). The former makes use of prototypes, wind tunnels and test tracks, making it a very expensive option. On the other hand, CFD makes use of numerical tools to solve the Navier-Stokes equations within a computational discretized domain. This latter approach is essentially limited by the available computational power and by the aerodynamicist's experience.
This work comprises eight chapters. The first one is an introduction to the type of flows and geometries considered, as well as, the general methodology followed in the posterior studies. The following six chapters are the core of this dissertation, and encompass the numerical resolution of the Navier-Stokes equations in selected geometries, ordered by complexity level. In particular, the contents of these seven chapters have been submitted or published in international journals and conferences. For this reason, they are self contained and few changes have been made. The reader might find that some concepts are repeated along them. The last chapter contains concluding remarks. Finally, appendix 1 describes some applications of aerodynamic studies to some related projects and appendix 2 comprises a list of publications done during the PhD.El análisis aerodinámico se ha convertido en una de las herramientas más importantes en diversidad de aplicaciones de ingeniería. En este contexto, esta tesis está enfocada a realizar análisis aerodinámicos en diferentes geometrías, contribuyendo datos nuevos a la comunidad científica y extrayendo información útil de los resultados obtenidos. Dichos análisis se pueden realizar, principalmente, de dos maneras: Mediante investigación experimental y mediante simulaciones numéricas (CFD). Para realizar experimentos se han de construir prototipos para su uso en túneles de viento y pistas de prueba, con los altos costos que esto conlleva. En otro extremo se encuentra el CFD, donde haciendo uso de herramientas computacionales se resuelven numéricamente las ecuaciones de Navier-Stokes en un dominio computacional. Este segundo enfoque se ve limitado por la potencia de cálculo disponible y la experiencia del aerodinamicista. Este trabajo se compone de ocho capítulos. En el primer capítulo se realiza una breve introducción a los tipos de flujos y geometrías consideradas en este estudio, así como la metodología a usar en el resto de capítulos . Los siguientes seis capítulos constituyen el cuerpo de este documento, y presentan la solución numérica y posterior análisis de las ecuaciones de Navier-Stokes en algunas geometrías de relevancia. Los contenidos de estos seis capítulos han sido presentados para su publicación en revistas indexadas y congresos. El último capítulo presenta las conclusiones extraídas de la presente tesis. Finalmente, el apéndice 1 presenta el análisis aerodinámico aplicado a problemas industriales reales, mientras que el apéndice 2 presenta la lista de publicaciones realizadas durante el desarrollo del doctorado.
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Jones, Kevin Theodore. "Genetic analysis of TOR complex 2 signaling." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378493.
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Faller, Daniel. "Analysis and dynamic modelling of complex systems." [S.l. : s.n.], 2003. http://www.freidok.uni-freiburg.de/volltexte/777.
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Emrich, Scott Joseph. "Assembly and analysis of complex plant genomes." [Ames, Iowa : Iowa State University], 2007.
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Beleza, Meireles Ana Maria. "Hypospadias : analysis of a complex genetic disorder /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-249-1/.
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Ansari, Morad. "Analysis of biomarkers for complex human diseases." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4505.
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The aims of this study were to analyse known and potential biomarkers of common and genetically complex human disorders and to identify genetic and environmental variation associated with plasma biomarker concentrations. Two groups of protein biomarkers were analysed. First, plasma complement factor H (CFH) was selected as a potential biomarker for age-related macular degeneration (AMD), since common variants in the CFH gene show strong association with this disorder. Secondly, two isoforms of amyloid-β (Aβ40 and Aβ42) were selected as biomarkers for Alzheimer disease (AD) since Aβ deposits are major constituents of the amyloid plaques characteristic of this disorder. Physiological and anthropometric measurements and samples of human and genomic DNA were collected from a population sample of 1,021 individuals from the Croatian island of Vis. Quantitative determination of plasma Aβ40 and Aβ42 concentrations was performed using enzyme-linked immunosorbent assays. Heritabilities and significant covariate effects were estimated for each trait in the Croatian data set. Genome-wide linkage and association analyses were conducted for the biomarker traits. A novel finding was the genome-wide significant association between a CFH and several polymorphisms close to and within the CFH gene. The strongest association was with an intronic SNP within CFH, which explained 28% of the total trait variance (P < 10-50). The association was also replicated in a Dutch sample set. A SNP haplotype was identified which accounted for a higher proportion of the phenotypic variance. Conditional haplotype analysis showed that the effect of this haplotype on plasma CFH concentration was independent of the CFH Y402H variant, and significantly stronger than a deletion of the adjacent CFHR3/CFHR1 which was already known to affect AMD susceptibility. Genetic analysis of 382 AMD cases and 201 controls was consistent with the CFH Y402H variant being the strongest AMD susceptibility locus. Variation in plasma CFH concentration was found to explain up to 1.8% of the variation in susceptibility to AMD with an odds 2.1 (95% C.I. 1.3-3.4, P = 0.003). SNPs that were strongly associated with a CFH concentration also influenced AMD susceptibility (P < 0.05) independently of the CFH Y402H polymorphism. Functional analysis of genomic regions associated with plasma CFH is needed to identify the causal variants. Associations were observed between plasma Aβ40 concentration and several novel candidate loci, spanning regions of approximately 0.2 Mb, on chromosomes 9 and X. Similarly, novel associations with plasma Aβ42 were found in several regions, each spanning 0.2-0.4 Mb, on chromosomes 2, 5, 9, 15 and 20. The proportion of the phenotypic variance in plasma Aβ42 explained by these putative associations ranged between 1.8 and 2.8%. However, none of the associated SNPs was significant after correction for multiple testing, therefore replication is required. Finally, attempts were made to identify and quantitate new protein biomarkers of disease in human plasma using mass spectrometry. Development and optimisation of techniques was initially undertaken to deplete high-abundance plasma proteins and improve signal:noise ratio. This allowed the assessment of downstream proteomic approaches including MALDI-TOF mass spectrometry (MS), capillary electrophoresis (CE) and ion exchange chromatography (IEC), each with the potential for large-scale quantitation of plasma proteins. Although the analysis of single protein analytes, using CE and IEC proved promising, the results highlighted the difficulty associated with MALDI-TOF and protein ionisation techniques in analysing complex mixtures such as plasma.
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Johri, Saurabh. "Evolutionary Analysis of the Mycobacterium Tuberculosis Complex." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498577.
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Conlin, Adrian Keith. "Complex sensor data analysis through data augmentation." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320016.
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Farooq, Abdul Rehman. "Dynamic photometric stereo for complex surface analysis." Thesis, University of the West of England, Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409451.
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Oakley, Jeremy. "Bayesian uncertainty analysis for complex computer codes." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322915.
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Kunze, Zubair M. "Genetic analysis of the Mycobacterium avium complex." Thesis, University of Surrey, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292346.
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Chen, Da. "The visual analysis of complex natural phenomena." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760925.
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Optical flow estimation or dense motion estimation for dynamic natural phenomena (water, smoke, fire, etc.) is a significant open problem in Computer Vision. Assumptions such as brightness constancy cannot be relied upon, as natural phenomena scenes contain lots of non- rigid motion, blurred motion, etc. Current approaches tend to be either general, giving poor results, or else be specialised in one phenomenon and therefore fail to generalise well. The literature would benefit from a general solution, and such a solution could be found useful in a diverse set of application areas. In this thesis, we prove that a skeleton based feature can guide the standard optical flow pipeline to obtain state-of-the-art motion results. We also demonstrate that this result can be applied in different applications such as video segmentation, slow motion, etc. First, we describe an approach to estimating dense motion for dynamic phenomena that is simple and can be extended to a wide range of phenomena. The key to our approach is to replace local assumptions such as brightness constancy with the global assumption in which characteristic topographic maps change subtly. This leads to a global sparse motion estimation, which upgrades to dense estimation for final motion results, as suggested in our experiments, are state-of-the-art. We demonstrate the method using lab-based and consumer-level video obtained from our dataset, public dataset and the Internet. Second, the motion result is applied on a slow motion application which contains fewer artefacts than the state-of-the-art commercial software Adobe AfterEffect 2017 CC. Third, we embed the motion result and the skeleton feature in a video segmentation pipeline and outperform the state-of-the-art video segmentation methods including the method which is specially designed for natural phenomena. Fourth, we introduce a dataset containing two types of sequences i.e., sequences based on a 6-sync cameras system and sequences with 88 different kinds of dynamic textures with a single view camera lab set-up. Fifth, since semi-transparent case often happens in natural phenomena, a closed form solution for layer separation is also proposed.
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Zheng, Feng. "Advanced electrochemical analysis for complex electrode applications." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288481.
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This thesis has investigated several complex situations that may be encountered in electrochemical studies. Three main situations have been examined, they include the formation of polymer films on electrode surfaces during measurements, a novel nanocatalyst modified electrode surfaces, and organised carbon nanotube (CNT) structures on electrode surfaces. These have been utilised for different electrochemical applications owing to their dissimilar properties. Voltammetric techniques of cyclic voltammetry (CV), square wave voltammetry (SWV) and Fourier transformed large amplitude ac voltammetry (FTACV) have been utilised to examine these reactions. Chapter 3 reports the investigation of catechol oxidation and subsequent polymerisation through crosslinking with D-glucosamine or chitosan. Hydrogel can be formed on the electrode surface during the process, which changes the viscosity of the solution and thus affects the diffusion of chemical species. This process has been examined by several voltammetric techniques. A further examination of the chemical system has also been conducted using FTACV for the first time. Chapter 4 describes the preparation of carbon microsphere supported molybdenum disulfide. The material has been utilised as electrocatalysts for hydrogen evolution reaction (HER) in acidic media, and the performance tested by traditional linear sweep voltammetry (LSV) and advanced FTACV techniques. The FTACV technique has been used for the first time for HER processes. In addition, the synthesised particles have also been used for thermal catalytic decomposition of hydrogen sulfide, which shows a significant improvement in the conversion rate over conventional examples. Chapter 5 demonstrates the direct growth of vertically aligned CNT forests on a gold electrode. The electrochemical response of the fabricated electrode has also been examined with ferrocyanide as the redox species. Furthermore, the immobilisation of anthraquinone onto CNT forest has been attempted. The fabricated electrode was utilised as a pH sensor via CV and SWV, and both indicates a well correlated pH-potential relationship in the pH range of 2 to 12. The sensor has also been assessed by the FTACV technique.
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Faranca, Anthony G. (Anthony Gilbert) 1971. "Complex system analysis through discrete event simulation." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34788.
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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2004.Includes bibliographical references (leaf 63).
E-commerce is generally thought of as a world without walls. Although a computer monitor may replace a storefront window, the products that are purchased online have to be distributed from a brick and mortar warehouse. Amazon.com now makes it possible to instantly order and quickly receive everything from CDs and books to large toys and home furnishings. Amazon's success not only depends on their e-business capabilities, but also on their distribution and warehouse management systems that support them. Fulfillment center management therefore has become an important component of Amazon's unique set of system activities that serve as a corporate strategy. In an attempt to improve current and future warehouse management practices, the engineering group at Amazon has recently invested in Discrete Event Simulation technology. This thesis focuses on the creation of a discrete event simulation of the Fernley, NV semi-automated distribution center's outbound flow process. More specifically, the business subjects investigated include: picker variability, tote diversion, item-per-tote reduction, and conveyor merge logic. The model presented is Amazon's first attempt at simulating this environment and serves as an initial step towards a more detailed simulation of this facility. Preliminary findings from the simulation are presented and the report is concluded with a cultural evaluation of the present engineering directive. It should be noted that this published version of the thesis has been approved by Amazon.com and does not contain any proprietary data. A fully detailed version of this thesis was only submitted to Amazon.com and to the advisors listed below.
by Anthony G. Faranca.
S.M.
M.B.A.
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De, Rivaz Peter Francis Chevalley. "Complex wavelet based image analysis and synthesis." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621155.
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Groves-Kirkby, Nick. "Genetic analysis of variation in complex traits." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4541c4e4-4538-4348-bb4b-0df6673344d2.
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Variation is a universal property of life, and much of contemporary genetics research is directed towards understanding the causes of variation in traits. Here I present the results of my investigations into the genetic and other causes of trait variation in humans and mice. I address these questions in the context of two distinct research projects, which use pre-existing data to investigate the causes of trait variation, through a range of analytic techniques. I first extract trait data from historic breeding records from the incipient Collaborative Cross (a genetic reference population of recombinant inbred mice) and use them to map genetic factors affecting litter size and other reproductive traits. Mapping reveals significant quantitative trait loci associated with litter size and time between litters, as well as a number of suggestive loci. I characterise the genetic effects at these loci and investigate candidate genes. The most robust finding, a litter size locus on chromosome 5, explains around 3% of observed variation and 24% of the variation attributable to genetics. Using data obtained from the Netherlands Twin Registry - a longitudinal database of Dutch twins - I investigate the prevalence of parent of origin effects on gene expression traits in peripheral blood in humans. I first phase individuals' genotypes by parental origin and use these genotypes to calculate the heritability of over 44,000 gene expression traits partitioned into that attributable to matching and nonmatching parent of origin. I replicate prior genomewide heritability estimates for many traits, but I find little evidence of widespread parent-of-origin effects on human gene expression in blood. On further examination, the small sample size severely limits the power to detect such effects. Nonetheless, I identify approximately 200 genes enriched for immune system processes that show evidence of parent-of-origin-specific effects on heritability.
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Hunt, Nicholas. "Molecular analysis of the Friend virus complex." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/108015/.
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This work was undertaken to molecularly clone the Nirand strain of the polycythaemia inducing Friend spleen focus forming virus (F-SFFVp) together with its replication competent helper virus. Friend murine leukaemia virus (F-MuLV). To this aim viral extrachromosomal DNA molecules (of both linear and circular nature corresponding to both of these viruses) which could be induced in Friend cell lines were molecularly characterised with respect to their quantitative increase during differentiation and subcellular location. One cell line, F4-6 in which considerable amounts of these extrachromosomal DNAs could be detected was utilised for the large scale production and purification of both SFFVp and F-MuLV extrachromosomal DNA molecules. Restriction enzyme analysis of such molecules in combination with Southern blotting enabled the construction of primary restriction enzyme maps which allowed the selection of a molecular cloning strategy. Both of these viruses were subsequently molecularly cloned and were subsequently shown to be biologically active after transfection into recipient cells. A further aspect of this work was to construct a biologically active SFFVp containing a dominant selectable marker gene. A selectable construct was generated by joining different regions of the genome of the myeloproliferative sarcoma virus (MPSV) and SFFVp. A construct with the U3 region from the long terminal repeat (LTR) of SFFVp and the envelope gene region (gp55) of SFFVp (designated neo2 SFFVp) was found to be fully active as a selectable retroviral vector with identical biological properties to the wild type SFFVp neo2 SFFVp induced erythroid differentiation in vivo, with infected cells no longer requiring erythropoietin for differentiation. Furthermore neo2 SFFVp infected spleen cells could be used to generate immortal Friend leukaemia cells which were selectable with geneticin (neo2). A further construct, neo2 SFFV-M, which had a U3 region originating from NPSV was able to cause erythropoietin independent erythroid differentiation. However as compared to neo2 SFFVp and indeed the wild type SFFVp, neo2 SFFV-M was able to induce the erythroproliferative disease with a different kinetics. All attempts to isolate transformed Friend cells with this construct failed.
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Al-Ofl, Abdalaziz Saleem. "Analysis of complex nonlinear reaction-diffusion equations." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2422/.
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A mathematical analysis has been carried out for some nonlinear reaction- diffusion equations on open bounded convex domains Ω C R(^d)(d < 3) with Robin boundary conditions- Existence, uniqueness and continuous dependence on initial data of weak and strong solutions are proved. A numerical analysis has also been undertaken for these nonlinear reaction- diffusion equations on the above domains. A fully practical piecewise linear finite element approximation is proposed for which existence and uniqueness of the numerical solution are proved. Semi-discrete and fully discrete error estimates are given. A practical algorithm for computing the numerical solution is given and its convergence is proved. Finally, some numerical simulations in one-dimensional space are exhibited.