Relevant bibliographies by topics / Complex and Mendelian Human Genetic

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Complex and Mendelian Human Genetic'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Complex and Mendelian Human Genetic"

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Tukker, Anke M., Charmaine D. Royal, Aaron B. Bowman, and Kimberly A. McAllister. "The Impact of Environmental Factors on Monogenic Mendelian Diseases." Toxicological Sciences 181, no. 1 (2021): 3–12. http://dx.doi.org/10.1093/toxsci/kfab022.

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Abstract Environmental factors and gene-environment interactions modify the variable expressivity, progression, severity, and onset of some classic (monogenic) Mendelian-inherited genetic diseases. Cystic fibrosis, Huntington disease, Parkinson’s disease, and sickle cell disease are examples of well-known Mendelian disorders that are influenced by exogenous exposures. Environmental factors may act by direct or indirect mechanisms to modify disease severity, timing, and presentation, including through epigenomic influences, protein misfolding, miRNA alterations, transporter activity, and mitoch
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Hershberger, Ray E., Jason Cowan, Elizabeth Jordan, and Daniel D. Kinnamon. "The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy." Circulation Research 128, no. 10 (2021): 1514–32. http://dx.doi.org/10.1161/circresaha.121.318157.

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Our insight into the diverse and complex nature of dilated cardiomyopathy (DCM) genetic architecture continues to evolve rapidly. The foundations of DCM genetics rest on marked locus and allelic heterogeneity. While DCM exhibits a Mendelian, monogenic architecture in some families, preliminary data from our studies and others suggests that at least 20% to 30% of DCM may have an oligogenic basis, meaning that multiple rare variants from different, unlinked loci, determine the DCM phenotype. It is also likely that low-frequency and common genetic variation contribute to DCM complexity, but neith
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Loftin, Madelene, Kelly East, Adam Hott, and Neil Lamb. "“Touching Triton”:." American Biology Teacher 78, no. 1 (2016): 15–21. http://dx.doi.org/10.1525/abt.2016.78.1.15.

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Life science classrooms often emphasize the exception to the rule when it comes to teaching genetics, focusing heavily on rare single-gene and Mendelian traits. By contrast, the vast majority of human traits and diseases are caused by more complicated interactions between genetic and environmental factors. Research indicates that students have a deterministic view of genetics, generalize Mendelian inheritance patterns to all traits, and have unrealistic expectations of genetic technologies. The challenge lies in how to help students analyze complex disease risk with a lack of curriculum materi
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Zhang, David, Sebastian Guelfi, Sonia Garcia-Ruiz, et al. "Incomplete annotation has a disproportionate impact on our understanding of Mendelian and complex neurogenetic disorders." Science Advances 6, no. 24 (2020): eaay8299. http://dx.doi.org/10.1126/sciadv.aay8299.

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Growing evidence suggests that human gene annotation remains incomplete; however, it is unclear how this affects different tissues and our understanding of different disorders. Here, we detect previously unannotated transcription from Genotype-Tissue Expression RNA sequencing data across 41 human tissues. We connect this unannotated transcription to known genes, confirming that human gene annotation remains incomplete, even among well-studied genes including 63% of the Online Mendelian Inheritance in Man–morbid catalog and 317 neurodegeneration-associated genes. We find the greatest abundance
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Carr, Fiona J., Martin W. McBride, Hilary V. O. Carswell, et al. "Genetic Aspects of Stroke: Human and Experimental Studies." Journal of Cerebral Blood Flow & Metabolism 22, no. 7 (2002): 767–73. http://dx.doi.org/10.1097/00004647-200207000-00001.

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As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. Risk factors can be identified and controlled at the level of lifestyle changes; however, genetic components of stroke have yet to be identified. The identification of such genetic components is critical in the understanding, diagnosis, and treatment of stroke in the future. This review focuses on the genetic determinants of stroke in both human and experimental systems. Mendelian disorders, candidate genes, and twin studies provide evidence for a strong genetic component of str
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Alcaïs, Alexandre, Claire Fieschi, Laurent Abel, and Jean-Laurent Casanova. "Tuberculosis in children and adults." Journal of Experimental Medicine 202, no. 12 (2005): 1617–21. http://dx.doi.org/10.1084/jem.20052302.

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Disseminated disease in children and pulmonary disease in adults constitute two major epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of infected individuals develop clinical tuberculosis, typically one form of the disease or the other. Mendelian and complex genetic predispositions to tuberculosis were reported recently in children and adults, respectively. Here, we argue that tuberculosis and its clinical expression largely reflect the underlying human genetic background.
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Shotwell, Mark. "The Misuse of Pedigree Analysis in the Eugenics Movement." American Biology Teacher 83, no. 2 (2021): 80–88. http://dx.doi.org/10.1525/abt.2021.83.2.80.

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Pedigree analysis has long been an essential tool in human genetics as well as a staple of genetics education. Students of genetics might be surprised to learn that human pedigrees were first popularized in the United States by proponents of eugenics, the pseudoscientific social movement aimed at improving the genetic quality of the human race. Notably, the influential eugenicist Charles B. Davenport employed pedigree charts to support his belief that not only were such medical conditions as Huntington disease and albinism inherited in a simple Mendelian fashion, but so too were such character
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Cherry, Timothy J., Marty G. Yang, David A. Harmin, et al. "Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease." Proceedings of the National Academy of Sciences 117, no. 16 (2020): 9001–12. http://dx.doi.org/10.1073/pnas.1922501117.

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The interplay of transcription factors and cis-regulatory elements (CREs) orchestrates the dynamic and diverse genetic programs that assemble the human central nervous system (CNS) during development and maintain its function throughout life. Genetic variation within CREs plays a central role in phenotypic variation in complex traits including the risk of developing disease. We took advantage of the retina, a well-characterized region of the CNS known to be affected by pathogenic variants in CREs, to establish a roadmap for characterizing regulatory variation in the human CNS. This comprehensi
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Dean, Michael. "Approaches to identify genes for complex human diseases: Lessons from Mendelian disorders." Human Mutation 22, no. 4 (2003): 261–74. http://dx.doi.org/10.1002/humu.10259.

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O'Neal, Wanda K., and Michael R. Knowles. "Cystic Fibrosis Disease Modifiers: Complex Genetics Defines the Phenotypic Diversity in a Monogenic Disease." Annual Review of Genomics and Human Genetics 19, no. 1 (2018): 201–22. http://dx.doi.org/10.1146/annurev-genom-083117-021329.

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In many respects, genetic studies in cystic fibrosis (CF) serve as a paradigm for a human Mendelian genetic success story. From recognition of the condition as a heritable pathological entity to implementation of personalized treatments based on genetic findings, this multistep pathway of progress has focused on the genetic underpinnings of CF clinical disease. Along this path was the recognition that not all CFTR gene mutations produce the same disease and the recognition of the complex, multifactorial nature of CF genotype–phenotype relationships. The non- CFTR genetic components (gene modif
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Dissertations / Theses on the topic "Complex and Mendelian Human Genetic"

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Spataro, Nino 1984. "Human genetic disorders: Mendelian and complex diseases." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/482220.

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From Darwin’s “On the Origin of Species”, many years elapsed before human diseases were considered in an evolutionary framework. Besides theoretical and empirical advances, we are far from the complete understanding of disease aetiology. Highly penetrant disorders with Mendelian inheritance are mostly explained by the mutation-selection balance model, which is insufficient to describe the selective pressures acting on the full set of alleles related to diseases. We show in the first two papers that Next Generation Sequencing (NGS) technologies provide a unique opportunity to investigate variat
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Lao, Grueso Oscar. "Història natural de les malalties genètiques mendelianes i complexes." Doctoral thesis, Universitat Pompeu Fabra, 2004. http://hdl.handle.net/10803/7210.

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Las enfermedades genéticas se clasifican típicamente en dos grandes grupos: las enfermedades mendelianas y las enfermedades complejas. Mientras que las enfermedades mendelianas se caracterizan por ser de baja frecuencia en la población y estar causadas por mutaciones en un gen particular, las enfermedades complejas son el principal problema sanitario en los países desarrollados y se encuentran producidas por la interacción de factores ambientales y factores genéticos. En este caso no se puede hablar de mutación en un determinado gen, sino de polimorfismo que incrementa en una pequeña fracción
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Lao, Grueso Oscar 1976. "Història natural de les malalties genètiques mendelianes i complexes." Doctoral thesis, Universitat Pompeu Fabra, 2004. http://hdl.handle.net/10803/7210.

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Las enfermedades genéticas se clasifican típicamente en dos grandes grupos: las enfermedades mendelianas y las enfermedades complejas. Mientras que las enfermedades mendelianas se caracterizan por ser de baja frecuencia en la población y estar causadas por mutaciones en un gen particular, las enfermedades complejas son el principal problema sanitario en los países desarrollados y se encuentran producidas por la interacción de factores ambientales y factores genéticos. En este caso no se puede hablar de mutación en un determinado gen, sino de polimorfismo que incrementa en una pequeña fracción
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Chen, Anlu. "Applying Forward Genetic Approaches to Rare Mendelian Disorders and Complex Traits." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1532522241487661.

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Vincent, Quentin. "Epidémiologie et génétique humaine de l’ulcère de Buruli." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05S019/document.

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L'ulcère de Buruli (UB), infection à Mycobacterium ulcerans, troisième mycobactériose mondiale, connait une émergence rapide depuis 1980, essentiellement dans les pays d'Afrique subsaharienne. Jusqu’ici, les connaissances épidémiologiques sur l’UB étaient fondées sur des séries de cas cliniques non confirmés par laboratoire. Nous avons constitué la plus grande cohorte de cas confirmés à ce jour rassemblant plus de 1200 patients traités au CDTUB de Pobè au Bénin entre 2005 et 2011, afin de décrire l'épidémiologie clinique de la maladie et d'explorer l’architecture génétique de la susceptibilité
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Moore, John M. "Using human examples to teach Mendelian genetic concepts : assessing acquisition and retention." Virtual Press, 1989. http://liblink.bsu.edu/uhtbin/catkey/558371.

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This study was designed to investigate whether or not Mendelian genetics instruction using human examples, in contrast to traditional genetic examples, would facilitate the acquisition and retention of four genetic concepts: (1) complete dominance, (2) incomplete dominance, (3) law of segregation, and (4) law of independent assortment. A pre/post/delayed-posttest was designed to assess the acquisition and retention of the concepts and the formation of misconceptions of genetic concepts. A written Piagetian Task Instrument (PTI) was employed to detect cognitive growth toward the formal operatio
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Stamm, Demetra Serena North Kari E. "Genetic investigation of both complex and Mendelian disorders neural tube defects and Native American myopathy /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1401.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Genetics." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
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Sun, Benjamin Boyang. "Genetic determinants of the human plasma proteome and their application in biology and disease." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269287.

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Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels (protein quantitative trait loci (pQTLs)). Limitations in high-throughput proteomic measurement technology have meant well-powered genome-wide association studies for large number of proteins so far have lagged behind many of the other "omic" studies such as transcriptomics and metabolomics. This is made more challenging by the complexity of human plasma, characterised by high dynamic range span
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Ying, Dingge, and 应鼎阁. "Identification of shared extended haplotypes in both population-based studies of complex disease and family-based studies of Mendelian disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205837.

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Recent founder mutations may play important roles in complex diseases and Mendelian disorders. Detecting shared haplotypes of identity by descent (IBD) could facilitate discovery of these mutations. Several programs address this such as threshold-based methods on genetic distance and probabilistic model-based methods, but they are usually limited to only detecting pair-wise shared haplotypes and not providing a comparison between cases and controls. In this study, a novel algorithm and a applied software package (HaploShare)is developed to detect extended haplotypes that are shared by multi
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Bell, Jordana Tzenova. "Epistasis in complex human traits." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:547db446-c84c-4a6c-8b5c-ce960f7765c5.

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Books on the topic "Complex and Mendelian Human Genetic"

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Mendelian inheritance in man: A catalog of human genes and genetic disorders. Johns Hopkins University Press, 1994.

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McKusick, Victor A. Mendelian inheritance in man: A catalog of human genes and genetic disorders. John Hopkins University Press, 1994.

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McKusick, Victor A. Mendelian inheritance in man: A catalog of human genes and genetic disorders. Johns Hopkins University Press, 1994.

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McKusick, Victor A. Mendelian inheritance in man: A catalog of human genes and genetic disorders. Johns Hopkins University Press, 1998.

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Ostrer, Harry. Non-mendelian genetics in humans. Oxford University Press, 1998.

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Genes, chromosomes, and disease: From simple traits, to complex traits, to personalized medicine. FT Press Science, 2011.

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Zeggini, Eleftheria. Analysis of complex disease association studies: A practical guide. Academic Press/Elsevier, 2011.

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Catalog of human cancer genes: McKusick's Mendelian inheritance in man for clinical and research oncologists (onco-MIM). Johns Hopkins University Press, 1999.

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McKusick, Victor A. Mendelian inheritance in man: Catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes. 9th ed. Johns Hopkins University Press, 1990.

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Mendelian inheritance in man: Catalogs of autosomal dominant, autosomal recessive, and x-linked phenotypes. 7th ed. Johns Hopkins University Press, 1986.

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Book chapters on the topic "Complex and Mendelian Human Genetic"

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Gojobori, Takashi, and Tadashi Imanishi. "Genetic Variability of Major Histocompatibility Complex in Human Populations." In Human Population Genetics. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2970-5_5.

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Matsushita, Hidetsuru, Sumio Goto, Yukihiko Takagi, Osamu Endo, and Kiyoshi Tanabe. "Human Exposure to Airborne Mutagens Indoors and Outdoors Using Mutagenesis and Chemical Analysis Methods." In Genetic Toxicology of Complex Mixtures. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5850-3_3.

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Mumford, Judy L., Robert S. Chapman, Stephen Nesnow, C. Tuker Helmes, and Xueming Li. "Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood Combustion in Xuan Wei, China." In Genetic Toxicology of Complex Mixtures. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5850-3_12.

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Kim, Richard W., and Peter J. Gruber. "Complex Genetics and the Etiology of Human Congenital Heart Disease." In Genetic Causes of Cardiac Disease. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27371-2_5.

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Nair, Shailaja, Yolaine Nkamga, and Bryson Hoover-Hankerson. "Polycystic Ovary Syndrome: An Overview of a Complex, Heterogenous Genetic Condition." In Advanced Concepts in Human Immunology: Prospects for Disease Control. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33946-3_9.

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Robilliard, Denis, and Cyril Fonlupt. "Towards Human-Competitive Game Playing for Complex Board Games with Genetic Programming." In Lecture Notes in Computer Science. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31471-6_10.

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Greene, Casey S., Douglas P. Hill, and Jason H. Moore. "Environmental Sensing of Expert Knowledge in a Computational Evolution System for Complex Problem Solving in Human Genetics." In Genetic Programming Theory and Practice VII. Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-1626-6_2.

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Granizo-Mackenzie, Delaney, and Jason H. Moore. "Multiple Threshold Spatially Uniform ReliefF for the Genetic Analysis of Complex Human Diseases." In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37189-9_1.

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Lathrop, G. M. "Quantitative Phenotype Analysis for Localization and Identification of Disease-Related Genes in a Complex Genetic Background." In Ciba Foundation Symposium 197 - Variation in the Human Genome. John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470514887.ch15.

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Jamrozik, Euzebiusz, and Michael J. Selgelid. "Drug-Resistant Infection: Causes, Consequences, and Responses." In Ethics and Drug Resistance: Collective Responsibility for Global Public Health. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-27874-8_1.

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Abstract This chapter provides an overview of the causes and consequences of, and possible policy responses to, the problem of drug resistance. Throughout, we highlight the ways that ethical and conceptual analyses can help to clarify relevant issues and improve policy, especially in public health, broadly conceived. Drug resistant pathogens arise, persist, spread, and produce harm due to a complex set of causes: biological processes (e.g., related to microbial evolution, the transmission of genetic determinants of resistance between microbes, and human host immunity) as well as human behaviors (e.g., antimicrobial use and hygiene practices) and other social factors (e.g., access to clean water, sanitation, healthcare, and antimicrobials). Furthermore, the ethically salient consequences of drug resistance include not only morbidity and mortality from untreatable infections (that are often inequitably distributed), but also broader effects on human freedom, privacy, and well-being. Public health ethicists are ideally placed to identify and weigh the values that might be promoted or compromised by potential policies and/or interventions that aim to address the problem of drug resistance. This chapter concludes by discussing potential policy responses, including those related to surveillance, research, animal and human antimicrobial use, the broader social determinants of health, infection control practices, and vaccination.
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Conference papers on the topic "Complex and Mendelian Human Genetic"

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Nouanesengsy, Boonthanome, Sang-Cheol Seok, Han-Wei Shen, and Veronica J. Vieland. "Using projection and 2D plots to visually reveal genetic mechanisms of complex human disorders." In 2009 IEEE Symposium on Visual Analytics Science and Technology. IEEE, 2009. http://dx.doi.org/10.1109/vast.2009.5333917.

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Farritor, Shane, and Jun Zhang. "Using a Neural Network to Determine Fitness in Genetic Design." In ASME 2001 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/detc2001/dac-21052.

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Abstract Many automated design approaches require an objective function to determine the quality of a given design. Often, this function depends on a complex relationship between many parameters. Some parameters may be subjective and the relationships difficult to quantify. This paper presents a method where a neural network is used to evaluate the quality of proposed designs during a genetic algorithm search. In general application of the approach, a human designer would propose candidate designs for a given problem. These candidate designs are used to train a neural network fitness function.
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Xu, Yuqing, Qingxin Meng, Kun Yu, Zhidan Xu, and Shengyuan Yan. "A Computer-Aided Layout Method for Human Machine Interface of Main Control Room." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75645.

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Layout of human machine interface (HMI) plays a very important role in the information transmission between the complex operating and monitoring system and operators. HMI layout of main control room can obviously affect the safety and efficiency of power plant. The unreasonable layout of HMI may influence operators’ judgment and operation under emergency condition, resulting in huge accidents. But up until now, it is difficult to make a all-sided and reasonable layout method for the components of HMI in main control room. For many factors can influence the layout result of HMI, such as importa
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Kamali, Kaivan, Lijun Jiang, John Yen, and K. W. Wang. "Using Q-Learning and Genetic Algorithms to Improve the Efficiency of Weight Adjustments for Optimal Control and Design Problems." In ASME 2005 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/detc2005-85303.

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In traditional optimal control and design problems, the control gains and design parameters are usually derived to minimize a cost function reflecting the system performance and control effort. One major challenge of such approaches is the selection of weighting matrices in the cost function, which are usually determined via trial and error and human intuition. While various techniques have been proposed to automate the weight selection process, they either can not address complex design problems or suffer from slow convergence rate and high computational costs. We propose a layered approach b
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Gladstone, Julia. "Exploring the Key Informational, Ethical and Legal Concerns to the Development of Population Genomic Databases for Pharmacogenomic Research." In InSITE 2005: Informing Science + IT Education Conference. Informing Science Institute, 2005. http://dx.doi.org/10.28945/2880.

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The completion of a high quality comprehensive sequence of the human genome has lead to the discovery of genetic links to complex diseases and the development of target drugs. Population genetic databases (PGDs) are a powerful resource to the systematic study of the genetic component of disease; in the quest to understand the impact of genetic factors on drug response data from laboratory experiments, computational methods and clinical studies must be integrated. The establishment of a pharmacogenomics knowledge base entails complex information management balanced with the appropriate legal an
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Qiu, Shiguang, Xu Jing, Xiumin Fan, Qichang He, and Dianliang Wu. "Analysis of Influence Factors of Virtual Human Real-Time Driven Accuracy and its Optimization in Virtual Reality Environment." In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-12917.

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In the case that a real operator drives a virtual human in real-time using the motion capture method and performs complex products assembling and disassembling simulation, a very high driven accuracy is needed to meet the quality requirements of interactivity and simulation results. In order to improve the driven accuracy in virtual reality environment, a method is put forward which analyzes the influence factors of virtual human real-time driven accuracy and optimize the factors. A systematical analysis of factors affecting the accuracy is given. The factors can be sorted into hardware factor
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Pidard, D., A. Fischer, C. Bouillot, F. Ledeist, and A. T. Nurden. "INHERITED DEFICIENCIESCAN AFFECT SEPARATELY THE PLATELET MEMBRANE GLYCOPROTEIN Ilb-IIIa COMPLEX AND THE LEUKOCYTE LFA-1, Mac-1 and pl50,95 COMPLEXES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643704.

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The human platelet membrane glycoprotein (GP) IIb-IIIa complex and a family of functional leukocyte cell membrane antigens, LFA-1 (L), Mac-1 (M) andpl50,95 (X), possess knownstructural analogies. Similaritiesinclude a heterodimeric structure with a high mol. wt. αsubunit (Mr∽ 145-180 kDa) , associated nonconvalently with a lower mol. wt.β-subunit (Mr ∽ 90-95 kDa),anda partial amino acid sequence hommology between GP lib and αL or CKM. Furthermore, GP lib, α L and αM were reported to be co-expressed in murine cells transfected with a 20 kilobase human DNA fragment.To address the question of a p
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Chen, Tongjian, Yonghong Peng, Weiqiang Xie, and Hongming Deng. "GA-Based Fuzzy Neural Network for Adaptive Fuzzy Modeling and Control." In ASME 1998 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/detc98/cie-5556.

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Abstract Fuzzy logic theory has provided a model-free tool to develop intelligent control system for complex industrial processes by means of simulating the fuzzy reasoning process of human being. However, the performance of such a control system depends on the knowledge base (control rules and membership functions of fuzzy sets). For the control of complex industrial process in which the dynamic parameters of process is time-varying and non-linear, it is necessary to modify and optimize the knowledge base on-line. Adaptive fuzzy control provides a efficient approach for this objective. In thi
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He, Liang, Sean Phillips, Steven Waslander, and William Melek. "Task Based Pose Optimization of Modular Mobile Manipulators." In ASME 2012 11th Biennial Conference on Engineering Systems Design and Analysis. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/esda2012-83010.

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We propose a task based pose optimization method for modular mobile manipulators. The modular mobile manipulators are designed and prototyped by researchers at University of Waterloo. The intended application of the modular mobile manipulator is to assist urban search and rescue in unstructured environments. A single mobile manipulator with limited capability cannot achieve complex tasks in this application. When several modular mobile manipulators are linked to one another, they can perform complex tasks through decentralized collaboration. The focus of this research is to develop and simulat
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Duperray, A., A. Troesch, R. Berthier, E. Chagnon, and G. Marguerie. "BIOSYNTHESIS AND ASSEMBLY OF PLATELET GPIIbIIIa." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643958.

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Abstract:
Platelet GPIIbIIIa is a calcium-dependent heterodimer which is constituted of two proteins subunits GPIIb and GPIIIa. The GPIIb is itself made of two disulfide-linked subunits IIba and IIbβ. GPIlia is a single chain protein. GPIIbIIIa serves as a receptor for fibrinogen, fibronectin and von Willebrand factor and is implicated in platelet adhesive reactions. This protein is a member of an adhesion receptor protein family for which the name “cytoadhesins” has been proposed. As a preliminary step in the study of the genetic diversity of the members of this family, we have analysed the biosynthesi
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Reports on the topic "Complex and Mendelian Human Genetic"

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Rajarajan, Kunasekaran, Alka Bharati, Hirdayesh Anuragi, et al. Status of perennial tree germplasm resources in India and their utilization in the context of global genome sequencing efforts. World Agroforestry, 2020. http://dx.doi.org/10.5716/wp20050.pdf.

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Tree species are characterized by their perennial growth habit, woody morphology, long juvenile period phase, mostly outcrossing behaviour, highly heterozygosity genetic makeup, and relatively high genetic diversity. The economically important trees have been an integral part of the human life system due to their provision of timber, fruit, fodder, and medicinal and/or health benefits. Despite its widespread application in agriculture, industrial and medicinal values, the molecular aspects of key economic traits of many tree species remain largely unexplored. Over the past two decades, researc
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