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Journal articles on the topic 'Complex biomaterials'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Macnair, R., M. J. Underwood, and G. D. Angelini. "Biomaterials and cardiovascular devices." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 6 (1998): 465–71. http://dx.doi.org/10.1243/0954411981534222.

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In the field of cardiovascular surgery there is presently a lack of biomaterials possessing essential characteristics of the native tissue or organ which is to be replaced. This paper describes various biomaterials that have been introduced into the circulatory system and the complex reactions that subsequently occur. The risk of infection is also discussed as well as prevention and treatment regimes that can be used. Examples of future biomaterial development are outlined in an attempt to achieve biocompatibility.

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BALTATU, Madalina Simona, Petrica VIZUREANU, Andrei Victor SANDU, Iustinian BALTATU, Doru Dumitru BURDUHOS-NERGIS, and Marcelin BENCHEA. "PROSPECTS ON TITANIUM BIOMATERIALS." European Journal of Materials Science and Engineering 8, no. 4 (2023): 201–12. http://dx.doi.org/10.36868/ejmse.2023.08.04.201.

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Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either a therapeutic or diagnostic one. Biomaterials have a rich history of evolution, as they have continuously transformed from simple inert substances to complex, interactive materials, designed to communicate with biological systems and promote tissue regeneration and healing. Titanium, due to its excellent biocompatibility, corrosion resistance, and mechanical properties, has established its place as one of the most used biomaterials, particularly in orthopedics and dental appl

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Petković, Dušan, Miloš Madić, and Goran Radenković. "Knee Prosthesis Biomaterial Selection by Using MCDM Solver." Advanced Technologies & Materials 46, no. 2 (2021): 37–41. http://dx.doi.org/10.24867/atm-2021-2-006.

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Biomaterials are a special class of contemporary materials used to make prostheses, parts of organs or to replace entire organs. They are used to replace soft and hard tissues. Metal biomaterials are mostly used to replace hard bone tissues and joints. There is no ideal substitution for natural biological material, but each of the biomaterials has a number of advantages and disadvantages. The problem of choosing the most favorable biomaterial is a complex process of multi‐criteria decision‐making, which requires a lot of knowledge and experience. In order to help decision makers in solving thi

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Leeuwenburgh, Sander. "Self-healing biomaterials for medical applications." MATEC Web of Conferences 378 (2023): 01003. http://dx.doi.org/10.1051/matecconf/202337801003.

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Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties are required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing in order to improve the functionality of traditional biomaterials in terms of their mechanical, handling and biological properties. This presentation will provide a comprehensive overview of the field of self-healing biomaterials, ran

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Kim, Alexia, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, and Michelle Griffin. "Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response." Bioengineering 10, no. 12 (2023): 1411. http://dx.doi.org/10.3390/bioengineering10121411.

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Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the com

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Bettinger, Christopher J. "Synthesis and microfabrication of biomaterials for soft-tissue engineering." Pure and Applied Chemistry 81, no. 12 (2009): 2183–201. http://dx.doi.org/10.1351/pac-con-09-07-10.

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Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections:

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Chow, Lesley W., and Jacob F. Fischer. "Creating biomaterials with spatially organized functionality." Experimental Biology and Medicine 241, no. 10 (2016): 1025–32. http://dx.doi.org/10.1177/1535370216648023.

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Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biom

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Sask, Kyla N., Bruce Thong, Negar Goodarzynejad, Leslie R. Berry, and Anthony K. C. Chan. "Immunospecific analysis of in vitro and ex vivo surface-immobilized protein complex." Biointerphases 17, no. 2 (2022): 021005. http://dx.doi.org/10.1116/6.0001783.

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Biomaterials used for blood contacting devices are inherently thrombogenic. Antithrombotic agents can be used as surface modifiers on biomaterials to reduce thrombus formation on the surface and to maintain device efficacy. For quality control and to assess the effectiveness of immobilization strategies, it is necessary to quantify the surface-immobilized antithrombotic agent directly. There are limited methods that allow direct quantification on device surfaces such as catheters. In this study, an enzyme immunoassay (EIA) has been developed to measure the density of a synthetic antithrombin-h

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PRESTWICH, GLENN D., and HOWARD MATTHEW. "Hybrid, Composite, and Complex Biomaterials." Annals of the New York Academy of Sciences 961, no. 1 (2002): 106–8. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03058.x.

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Agrawal, Ishita, and Piyush Dua. "Surface Modification of Advanced Biomaterials for Applications in the Pharmaceutical and Medical Fields." Biotechnology Kiosk 4, no. 3 (2022): 1–16. http://dx.doi.org/10.37756/bk.22.4.3.1.

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Lately, there has been a great deal of emphasis on developing novel biomaterials for next generation biomedical technologies. Especially, research efforts have focused on biomaterials that meet the demand for precisely engineered three-dimensional structures. These research efforts seek to design advanced biomaterials that mimic the natural environments of tissues more closely, and thus enhance the functional performance of these materials. To this end, surface modification/functionalization of biomaterials is considered pivotal to achieve the goals. Recent progress in biomaterials fabrication

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Honig, Floris, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, and Lidy E. Fratila-Apachitei. "Natural Architectures for Tissue Engineering and Regenerative Medicine." Journal of Functional Biomaterials 11, no. 3 (2020): 47. http://dx.doi.org/10.3390/jfb11030047.

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The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the h

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James, Roshan, Paulos Mengsteab, and Cato T. Laurencin. "Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues." MRS Advances 1, no. 18 (2016): 1255–63. http://dx.doi.org/10.1557/adv.2016.282.

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ABSTRACT‘Regenerative Engineering’ is the integration of advanced materials science, stem cell science, physics, developmental biology and clinical translation to regenerate complex tissues and organ systems. Advanced biomaterial and stem cell science converge as mechanisms to guide regeneration and the development of prescribed cell lineages from undifferentiated stem cell populations. Studies in somite development and tissue specification have provided significant insight into pathways of biological regulation responsible for tissue determination, especially morphogen gradients, and paracrin

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Hakim, Lotfollah Kamali, Mohsen Yazdanian, Mostafa Alam, et al. "Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity." Evidence-Based Complementary and Alternative Medicine 2021 (November 13, 2021): 1–12. http://dx.doi.org/10.1155/2021/9011226.

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Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and

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Stamboliev, I. A., Julia Vladimirovna Gazhva, S. G. Ivashkevich, and V. M. Ryabova. "CURRENT APPROACHES OF BONE TISSUE ENGINEERING." Russian Journal of Dentistry 22, no. 2 (2018): 111–16. http://dx.doi.org/10.18821/1728-2802-2018-22-2-111-116.

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This article discusses the modern approaches of bone tissue engineering in oral and maxillofacial surgery for repair of bone integrity. Describes the new biomaterials in bone tissue engineering, complex scaffolds containing MSC for bone repair of large and critical bone defects, the criteria for selecting biomaterial scaffolds, as well as their positive and negative properties.

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Gristina, A. G., G. Giridhar, B. L. Gabriel, P. T. Naylor, and Q. N. Myrvik. "Cell Biology and Molecular Mechanisms in Artificial Device Infections." International Journal of Artificial Organs 16, no. 11 (1993): 755–64. http://dx.doi.org/10.1177/039139889301601103.

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Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacement and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barrier to the extended use of these devices is bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Adhesion-mediated infections are extremely resistant to antibiotics and host defenses and frequently persist until the biomater

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Aminov, Liana, Eusebiu Viorel Sindilar, Aurelian Sorin Pasca, et al. "In Vivo Evaluation of Biocompatibility of Three Biomaterials Used in Endodontics for Prosthetic Purposes in Complex Rehabilitation Treatment." Applied Sciences 11, no. 14 (2021): 6519. http://dx.doi.org/10.3390/app11146519.

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The ideal biomaterial used in endodontics in the process of sealing the radicular canals should possess a group of qualities for a predictable outcome: biocompatibility, initiation of ontogenesis and cementogenesis, ease of handling, sufficient manipulation time, and convenient price. For a perfect sealing, the root canal treatment can be followed by prosthetic restoration. This study of biocompatibility aims to determine the quantification of the local reaction following the implantation of three biomaterials in the rabbit subcutaneous connective tissue. The used biomaterials with particular

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Chaudhry, Afeefa, Aleesha Naheed, Zaima Latif, Sehar Nadeem, Natasha Mehmood, and Mishal Arzoo. "Applications and Limitations of 3D Bioprinters in Tissue Culturing: A Review." Volume 5 Issue 1, Volume 5 Issue 1 (June 30, 2022): 31–43. http://dx.doi.org/10.34091/ajls.5.1.4.

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3D bioprinting is an advanced technology that uses different biomaterial like hydrogels and bio-inks to develop artificial tissue cells and organs. There are three types of bioprinting techniques: Jetting-based bioprinting, extrusion based bioprinting, and integrated bioprinting. Biomaterials used in 3D bioprinter should have some ideal characteristics such as they should be biocompatible, printable, and provide mechanical and structural properties. There are different types of bio-inks, hydrogels, and growth factors used to overcome the crisis of organ shortage. Bioprinting technology is esse

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18

Mereddy, Rishith R., Emily E. Zona, Camille J. LaLiberte, and Aaron M. Dingle. "Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review." Journal of Functional Biomaterials 16, no. 3 (2025): 97. https://doi.org/10.3390/jfb16030097.

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Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including

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Akram, Ambreen, Mujahid Iqbal, Aqeela Yasin, Kun Zhang, and Jingan Li. "Sulfonated Molecules and Their Latest Applications in the Field of Biomaterials: A Review." Coatings 14, no. 2 (2024): 243. http://dx.doi.org/10.3390/coatings14020243.

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This review provides an overview of the latest applications of sulfonated molecules in biomaterials. Sulfonation, a chemical modification process introducing sulfonic acid groups, enhances biomaterial properties. This review explores the effect of sulfonation and recent innovations in biomaterial applications. It covers hydrogels, scaffolds, and nanoparticles, emphasizing sulfonation’s unique advantages. The impact on cellular responses, including adhesion, proliferation, and differentiation, is discussed. This review also addresses sulfonated biomaterials’ role in regenerative medicine, drug

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Kurowiak, Jagoda, Krystian Piesik, and Tomasz Klekiel. "Current State of Knowledge Regarding the Treatment of Cranial Bone Defects: An Overview." Materials 18, no. 9 (2025): 2021. https://doi.org/10.3390/ma18092021.

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In this article, an analysis of the problem of treating bone defects using cranial bone disorders as an example is presented. The study was performed in the context of the development of various implant biomaterials used to fill bone defects. An analysis of the requirements for modern materials is undertaken, indicating the need for their further development. The article focuses particular attention on these biomaterial properties, which have an influence on bioresorbability and promote osteointegration and bone growth. The analysis showed the need for further development of biomaterials, the

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Chen, Manyu, Qiguang Wang, Yunbing Wang, Yujiang Fan, and Xingdong Zhang. "Biomaterials-assisted exosomes therapy in osteoarthritis." Biomedical Materials 17, no. 2 (2022): 022001. http://dx.doi.org/10.1088/1748-605x/ac4c8c.

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Abstract Due to the avascular characteristic of articular cartilage, its self-repair capacity is limited. When cartilage is damaged or forms osteoarthritis (OA), clinical treatment is necessary. However, conventional treatments, including joint replacement, microfracture, cell and drug therapies, have certain limits. Lately, the exosomes derived from mesenchymal stem cells (MSCs-EXO), which consist of complex transcription factors, proteins and targeting ligand components, have shown great therapeutic potentials. With recent advancements in various biomaterials to extend MSCs-EXO’s retention t

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Chan, Weng Wan, David Chen Loong Yeo, Vernice Tan, Satnam Singh, Deepak Choudhury, and May Win Naing. "Additive Biomanufacturing with Collagen Inks." Bioengineering 7, no. 3 (2020): 66. http://dx.doi.org/10.3390/bioengineering7030066.

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Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various

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Islam, Mohammad Ariful, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter, and Jinjun Shi. "Biomaterials for mRNA delivery." Biomaterials Science 3, no. 12 (2015): 1519–33. http://dx.doi.org/10.1039/c5bm00198f.

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Schematic representation of various biomaterial-based systems for mRNA delivery: (a) protamine–mRNA complex; (b) lipid nanoparticle; (c) lipid nanoparticle with inorganic compounds (e.g.apatite); (d) cationic polymeric nanoparticle; (e) lipid–polymer hybrid nanoparticles including (i) mRNA–polymer complex core surrounded by a lipid shell and (ii) polymer core surrounded by a lipid shell with mRNA absorbed onto the surface; and (f) gold nanoparticle.

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Levin, Alexandra, Vaibhav Sharma, Lilian Hook, and Elena García-Gareta. "The importance of factorial design in tissue engineering and biomaterials science: Optimisation of cell seeding efficiency on dermal scaffolds as a case study." Journal of Tissue Engineering 9 (January 1, 2018): 204173141878169. http://dx.doi.org/10.1177/2041731418781696.

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This article presents a case study to show the usefulness and importance of using factorial design in tissue engineering and biomaterials science. We used a full factorial experimental design (2 × 2 × 2 × 3) to solve a routine query in every biomaterial research project: the optimisation of cell seeding efficiency for pre-clinical in vitro cell studies, the importance of which is often overlooked. In addition, tissue-engineered scaffolds can be cellularised with relevant cell type(s) to form implantable tissue constructs, where the cell seeding method must be reliable and robust. Our results s

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Torrealba, Débora, Joaquin Seras-Franzoso, Uwe Mamat, et al. "Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms." PLOS ONE 11, no. 10 (2016): e0164073. http://dx.doi.org/10.1371/journal.pone.0164073.

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Kretlow, James D., Simon Young, Leda Klouda, Mark Wong, and Antonios G. Mikos. "Injectable Biomaterials for Regenerating Complex Craniofacial Tissues." Advanced Materials 21, no. 32-33 (2009): 3368–93. http://dx.doi.org/10.1002/adma.200802009.

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Al-Maawi, Sarah, Carlos Herrera-Vizcaíno, Anna Orlowska, et al. "Biologization of Collagen-Based Biomaterials Using Liquid-Platelet-Rich Fibrin: New Insights into Clinically Applicable Tissue Engineering." Materials 12, no. 23 (2019): 3993. http://dx.doi.org/10.3390/ma12233993.

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Platelet-rich fibrin (PRF) is a blood concentrate derived from venous blood that is processed without anticoagulants by a one-step centrifugation process. This three-dimensional scaffold contains inflammatory cells and plasma proteins entrapped in a fibrin matrix. Liquid-PRF was developed based on the previously described low-speed centrifuge concept (LSCC), which allowed the introduction of a liquid-PRF formulation of fibrinogen and thrombin prior to its conversion to fibrin. Liquid-PRF was introduced to meet the clinical demand for combination with biomaterials in a clinically applicable and

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Khanna, Astha, Maedeh Zamani, and Ngan F. Huang. "Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering." Journal of Cardiovascular Development and Disease 8, no. 11 (2021): 137. http://dx.doi.org/10.3390/jcdd8110137.

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Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancement

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Chew, Sue Anne, Stefania Moscato, Sachin George, Bahareh Azimi, and Serena Danti. "Liver Cancer: Current and Future Trends Using Biomaterials." Cancers 11, no. 12 (2019): 2026. http://dx.doi.org/10.3390/cancers11122026.

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Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review sum

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Candelari, Mara, Ida Anna Cappello, Luigi Pannone, et al. "3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation." Journal of Clinical Medicine 12, no. 3 (2023): 1036. http://dx.doi.org/10.3390/jcm12031036.

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Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the tempera

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Ødegaard, Kristin S., Jan Torgersen, and Christer W. Elverum. "Structural and Biomedical Properties of Common Additively Manufactured Biomaterials: A Concise Review." Metals 10, no. 12 (2020): 1677. http://dx.doi.org/10.3390/met10121677.

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Biomaterials are in high demand due to the increasing geriatric population and a high prevalence of cardiovascular and orthopedic disorders. The combination of additive manufacturing (AM) and biomaterials is promising, especially towards patient-specific applications. With AM, unique and complex structures can be manufactured. Furthermore, the direct link to computer-aided design and digital scans allows for a direct replicable product. However, the appropriate selection of biomaterials and corresponding AM methods can be challenging but is a key factor for success. This article provides a con

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Kesti, Matti, Christian Eberhardt, Guglielmo Pagliccia, et al. "Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials." Advanced Functional Materials 25, no. 48 (2015): 7406–17. http://dx.doi.org/10.1002/adfm.201503423.

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Filip, Diana Georgiana, Vasile-Adrian Surdu, Andrei Viorel Paduraru, and Ecaterina Andronescu. "Current Development in Biomaterials—Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review." Journal of Functional Biomaterials 13, no. 4 (2022): 248. http://dx.doi.org/10.3390/jfb13040248.

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Inorganic biomaterials, including different types of metals and ceramics are widely used in various fields due to their biocompatibility, bioactivity, and bioresorbable capacity. In recent years, biomaterials have been used in biomedical and biological applications. Calcium phosphate (CaPs) compounds are gaining importance in the field of biomaterials used as a standalone material or in more complex structures, especially for bone substitutes and drug delivery systems. The use of multiple dopants into the structure of CaPs compounds can significantly improve their in vivo and in vitro activity

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Tatara, Alexander M., Gerry L. Koons, Emma Watson, et al. "Biomaterials-aided mandibular reconstruction using in vivo bioreactors." Proceedings of the National Academy of Sciences 116, no. 14 (2019): 6954–63. http://dx.doi.org/10.1073/pnas.1819246116.

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Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves suitable for their own specific anatomical pathology. The in vivo bioreactor strategy facilitates the generation of large autologous vascularized bony tissue of customized geometry without the addition of exogenous growth factors or cells. To translate this technology, we investi

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Chakraborty, Arnab, Fabien Deligey, Jenny Quach, Frederic Mentink-Vigier, Ping Wang, and Tuo Wang. "Biomolecular complex viewed by dynamic nuclear polarization solid-state NMR spectroscopy." Biochemical Society Transactions 48, no. 3 (2020): 1089–99. http://dx.doi.org/10.1042/bst20191084.

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Solid-state nuclear magnetic resonance (ssNMR) is an indispensable tool for elucidating the structure and dynamics of insoluble and non-crystalline biomolecules. The recent advances in the sensitivity-enhancing technique magic-angle spinning dynamic nuclear polarization (MAS-DNP) have substantially expanded the territory of ssNMR investigations and enabled the detection of polymer interfaces in a cellular environment. This article highlights the emerging MAS-DNP approaches and their applications to the analysis of biomolecular composites and intact cells to determine the folding pathway and li

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Cao, Uyen M. N., Yuli Zhang, Julie Chen, Darren Sayson, Sangeeth Pillai, and Simon D. Tran. "Microfluidic Organ-On-A-Chip: A Guide to Biomaterial Choice and Fabrication." International Journal of Molecular Sciences 24, no. 4 (2023): 3232. http://dx.doi.org/10.3390/ijms24043232.

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Organ-on-a-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to recapitulate the in vivo physiology of an organ using different cell types and extracellular matrix, while maintaining the chemical and mechanical properties of the surrounding microenvironments. From an end-point perspective, the success of a microfluidic OoAC relies mainly on the type of biomaterial and the fabrication strategy employed. Certain biomaterials, such as PDMS (polydimethylsiloxane), are preferred over others due to their ease of fabrication and proven success in modelling complex organ s

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Varghese, Jothi, Anjale Rajagopal, and Shashikiran Shanmugasundaram. "Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review." Polymers 14, no. 15 (2022): 3038. http://dx.doi.org/10.3390/polym14153038.

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Periodontal infections are noncommunicable chronic inflammatory diseases of multifactorial origin that can induce destruction of both soft and hard tissues of the periodontium. The standard remedial modalities for periodontal regeneration include nonsurgical followed by surgical therapy with the adjunctive use of various biomaterials to achieve restoration of the lost tissues. Lately, there has been substantial development in the field of biomaterial, which includes the sole or combined use of osseous grafts, barrier membranes, growth factors and autogenic substitutes to achieve tissue and bon

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Liu, Siyu, Tianlin Wang, Shenglong Li, and Xiaohong Wang. "Application Status of Sacrificial Biomaterials in 3D Bioprinting." Polymers 14, no. 11 (2022): 2182. http://dx.doi.org/10.3390/polym14112182.

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Additive manufacturing, also known as three-dimensional (3D) printing, relates to several rapid prototyping (RP) technologies, and has shown great potential in the manufacture of organoids and even complex bioartificial organs. A major challenge for 3D bioprinting complex org unit ans is the competitive requirements with respect to structural biomimeticability, material integrability, and functional manufacturability. Over the past several years, 3D bioprinting based on sacrificial templates has shown its unique advantages in building hierarchical vascular networks in complex organs. Sacrifici

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Shick, Tang Mei, Aini Zuhra Abdul Kadir, Nor Hasrul Akhmal Ngadiman, and Azanizawati Ma’aram. "A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering." Journal of Bioactive and Compatible Polymers 34, no. 6 (2019): 415–35. http://dx.doi.org/10.1177/0883911519877426.

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The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design

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Palomino-Durand, Carla, Emmanuel Pauthe, and Adeline Gand. "Fibronectin-Enriched Biomaterials, Biofunctionalization, and Proactivity: A Review." Applied Sciences 11, no. 24 (2021): 12111. http://dx.doi.org/10.3390/app112412111.

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Modern innovation in reconstructive medicine implies the proposition of material-based strategies suitable for tissue repair and regeneration. The development of such systems necessitates the design of advanced materials and the control of their interactions with their surrounding cellular and molecular microenvironments. Biomaterials must actively engage cellular matter to direct and modulate biological responses at implant sites and beyond. Indeed, it is essential that a true dialogue exists between the implanted device and the cells. Biomaterial engineering implies the knowledge and control

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Zakrzewski, Wojciech, Zbigniew Rybak, Magdalena Pajączkowska, et al. "Antimicrobial Properties and Cytotoxic Effect Evaluation of Nanosized Hydroxyapatite and Fluorapatite Dedicated for Alveolar Bone Regeneration." Applied Sciences 14, no. 17 (2024): 7845. http://dx.doi.org/10.3390/app14177845.

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Background: Alveolar bone augmentation is a complex process influenced by a multitude of factors. The materials applied in augmentation procedures must be confirmed as non-toxic, and their physicochemical properties should allow proper bone reconstruction. The specifics of oral surgical procedures require the use of regenerative biomaterials with antimicrobial properties. This study focuses on the physicochemical characteristics of chosen nanosized biomaterials, as well as their cytotoxicity and antimicrobial properties. Methods: nanosized hydroxyapatite and fluorapatite (abbreviated as nHAp a

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Dorogin, Jonathan, Jakob M. Townsend, and Marian H. Hettiaratchi. "Biomaterials for protein delivery for complex tissue healing responses." Biomaterials Science 9, no. 7 (2021): 2339–61. http://dx.doi.org/10.1039/d0bm01804j.

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Ilyas, R. A., M. Y. M. Zuhri, Mohd Nor Faiz Norrrahim, et al. "Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications." Polymers 14, no. 1 (2022): 182. http://dx.doi.org/10.3390/polym14010182.

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Recent developments within the topic of biomaterials has taken hold of researchers due to the mounting concern of current environmental pollution as well as scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed to be a great potential biomaterial, especially to the tissue engineering sector, due to its advantages, including its biocompatibility and low bioactivity exhibition. The commercialization of PCL is deemed as infant technology despite of all its advantages. This contributed to the disadvantages of PCL, including expensive, toxic, and complex. Therefo

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Kaushik, Neha, Linh Nhat Nguyen, June Hyun Kim, Eun Ha Choi, and Nagendra Kumar Kaushik. "Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering." International Journal of Molecular Sciences 21, no. 18 (2020): 6544. http://dx.doi.org/10.3390/ijms21186544.

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In the field of tissue engineering, there are several issues to consider when designing biomaterials for implants, including cellular interaction, good biocompatibility, and biochemical activity. Biomimetic mineralization has gained considerable attention as an emerging approach for the synthesis of biocompatible materials with complex shapes, categorized organization, controlled shape, and size in aqueous environments. Understanding biomineralization strategies could enhance opportunities for novel biomimetic mineralization approaches. In this regard, mussel-inspired biomaterials have recentl

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Da Silva, Jessica, Ermelindo C. Leal, Eugénia Carvalho, and Eduardo A. Silva. "Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers." International Journal of Molecular Sciences 24, no. 12 (2023): 9900. http://dx.doi.org/10.3390/ijms24129900.

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The imbalance of local and systemic factors in individuals with diabetes mellitus (DM) delays, or even interrupts, the highly complex and dynamic process of wound healing, leading to diabetic foot ulceration (DFU) in 15 to 25% of cases. DFU is the leading cause of non-traumatic amputations worldwide, posing a huge threat to the well-being of individuals with DM and the healthcare system. Moreover, despite all the latest efforts, the efficient management of DFUs still remains a clinical challenge, with limited success rates in treating severe infections. Biomaterial-based wound dressings have e

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da Silva, Victor A., Bianca C. Bobotis, Felipe F. Correia, et al. "The Impact of Biomaterial Surface Properties on Engineering Neural Tissue for Spinal Cord Regeneration." International Journal of Molecular Sciences 24, no. 17 (2023): 13642. http://dx.doi.org/10.3390/ijms241713642.

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Tissue engineering for spinal cord injury (SCI) remains a complex and challenging task. Biomaterial scaffolds have been suggested as a potential solution for supporting cell survival and differentiation at the injury site. However, different biomaterials display multiple properties that significantly impact neural tissue at a cellular level. Here, we evaluated the behavior of different cell lines seeded on chitosan (CHI), poly (ε-caprolactone) (PCL), and poly (L-lactic acid) (PLLA) scaffolds. We demonstrated that the surface properties of a material play a crucial role in cell morphology and d

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Ren, Xiang, Qingwei Zhang, Kewei Liu, Ho-lung Li, and Jack G. Zhou. "Modeling of pneumatic valve dispenser for printing viscous biomaterials in additive manufacturing." Rapid Prototyping Journal 20, no. 6 (2014): 434–43. http://dx.doi.org/10.1108/rpj-03-2013-0025.

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Purpose – The purpose of this paper is establishing a general mathematical model and theoretical design rules for 3D printing of biomaterials. Additive manufacturing of biomaterials provides many opportunities for fabrication of complex tissue structures, which are difficult to fabricate by traditional manufacturing methods. Related problems and research tasks are raised by the study on biomaterials’ 3D printing. Most researchers are interested in the materials studies; however, the corresponded additive manufacturing machine is facing some technical problems in printing user-prepared biomater

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Jun, Soo-Kyung, Hae-Hyoung Lee, Hae-Won Kim, and Jung-Hwan Lee. "Regenerative medicine using dental tissue derived induced pluripotent stem cell-biomaterials complex." Journal of The Korean Dental Association 55, no. 12 (2017): 828–40. http://dx.doi.org/10.22974/jkda.2017.55.12.001.

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In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (

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Gul, Iqtidar Ahmed, Ahmad Majdi Abdul-Rani, Azlan Ahmad, Md Al-Amin, Abdul'azeez Abdu Aliyu, and Elhuseini Garba. "Surface Wettability Response of Hydroxyapatite-Doped Coatings on Metallic Biomaterials: A Concise Review." Solid State Phenomena 370 (March 26, 2025): 61–72. https://doi.org/10.4028/p-c4devs.

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The surface wettability of metallic biomaterials significantly influences the biological response of biomedical implants. However, the optimal degree of wettability depends on the specific coating or surface treatment applied to the biomaterial. Researchers have widely utilised hydroxyapatite coatings to modify implant surfaces to enhance bioactivity, biocompatibility, and osseointegration. This review article discussed the impact of hydroxyapatite-doped coatings on the surface wettability of metallic biomaterials. A systematic search of Scopus and Web of Science databases was conducted to rev

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Richard, Caroline. "Innovative Surface Treatments of Titanium Alloys for Biomedical Applications." Materials Science Forum 879 (November 2016): 1570–75. http://dx.doi.org/10.4028/www.scientific.net/msf.879.1570.

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Biomedical engineering is an advanced technology based on an extremely complex development of advanced biomaterials. Since the first Consensus Conference in Chester (UK) on Definitions in Biomaterials of the European Society for Biomaterials, in 1986, biomaterial was defined as ‘a bioinert or bioactive material used in a material advice, intended to interact with biological systems, restore functions of natural living tissues and organism in the body’. In this way, passive metallic materials (as titanium alloys), a broad spectrum of bioceramics, even biopolymers and all combinations of these b

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