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1

Angeli, Lucrezia, Sebastian Imperiale, Yubin Ding, Matteo Scampicchio, and Ksenia Morozova. "A Novel Stoichio-Kinetic Model for the DPPH• Assay: The Importance of the Side Reaction and Application to Complex Mixtures." Antioxidants 10, no. 7 (2021): 1019. http://dx.doi.org/10.3390/antiox10071019.

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The 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay is widely used to determine the antioxidant activity of food products and extracts. However, the common DPPH• protocol uses a two-point measurement and does not give information about the kinetics of the reaction. A novel stoichio-kinetic model applied in this study monitors the consumption of DPPH• by common antioxidants following the second order reaction. The fitting of such decay yields the rate constant k1, which describes the main reaction between antioxidants and DPPH•, and the rate constant k2, which is attributed to a slower side reactio
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Karakas, Zeynep, Yasin Yilmaz, Dolay Damla Celik, Agageldi Annayev, Selcan Demirel, and Serap Erdem Kuruca. "Total Oxidant and Antioxidant Capacity in Patients with Transfusion Dependent and Nondependent Beta Thalassemia." Blood 126, no. 23 (2015): 4573. http://dx.doi.org/10.1182/blood.v126.23.4573.4573.

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Abstract Background: The patients with β-thalassemia are usually under oxidative stress due to iron overload as a result of ineffective erythropoiesis and repeated transfusions. The endogen (uric acid, indirect bilirubin) and exogenous (ascorbic acid and vitamin E) antioxidants protect the cells from oxidative damage. The evaluation of antioxidant defense system can be easily done by measuring serum total antioxidant capacity. The aim of this study is to investigate the total oxidant (TOC) and antioxidant capacity (TAC) of patients with transfusion dependent (TDT) and nondependent (NTDT) β -th
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Horyn, O. I., та H. I. Falfushynska. "ЕКСТРАКТ МОМОРДІКИ ПРИГНІЧУЄ ОКИСНИЙ СТРЕС ТА ЗБІЛЬШУЄ ГЕМОЛІТИЧНУ СТІЙКІСТЬ ЕРИТРОЦИТІВ КОРОПА ЗА ВПЛИВУ ГЛЮКОЗИ". Scientific Issue Ternopil Volodymyr Hnatiuk National Pedagogical University. Series: Biology 75, № 1 (2019): 21–28. http://dx.doi.org/10.25128/2078-2357.19.1.3.

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Phytoextracts and natural antioxidants should provide promising results in therapeutic intervention for diabetes mellitus when they include into medical treatment scheme. The present study aimed to investigate the effect of Momordica charantia phytoextract alone and in complex-form with nano zinc oxide as well as zinc compounds on rate of hemolysis and oxidative stress parameters in Cyprinus carpio red blood cells (RBC) after their exposure to high glucose in vitro. The results have shown that the glucose treatment was capable to promote an increase in oxidative damage of lipids and proteins,
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Capodice, Jillian L., Debra L. Bemis, Ralph Buttyan, Steven A. Kaplan, and Aaron E. Katz. "Complementary and Alternative Medicine for Chronic Prostatitis/Chronic Pelvic Pain Syndrome." Evidence-Based Complementary and Alternative Medicine 2, no. 4 (2005): 495–501. http://dx.doi.org/10.1093/ecam/neh128.

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To discuss challenges concerning treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and review complementary and alternative medical (CAM) therapies being evaluated for this condition, we performed a comprehensive search of articles published from 1990–2005 using the PubMed, Medline databases. Data from the articles were abstracted and pooled by subject. Keywords cross-searched with CP/CPPS included: complementary, alternative, integrative, therapies, interventions, nutrition, antioxidants, herbs, supplements, biofeedback and acupuncture. Listed articles with no abstracts
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Faria, TC, C. C. H. C. Nascimento, S. D. D. De Vasconcelos, and P. R. S. Stephens. "Literature Review on the Biological Effects of Taraxacum Officinale Plant In Therapy." Asian Journal of Pharmaceutical Research and Development 7, no. 3 (2019): 94–99. http://dx.doi.org/10.22270/ajprd.v7i3.502.

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Since human beings have sought in nature, components that can obtain help in therapeutics or even in the cure of diseases. The progress made in the area of ​​science promoted the development of recognized and effective herbal medicines, as well as the search for the population, for less aggressive treatments. The evaluation of the antioxidant activity of plants has been an important issue taking into account its importance on human health, since the natural antioxidants present a reduced health risk, when compared to the synthetic ones that present toxic effect. From the Asteraceae family, of
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Chumburidze, Gocha. "The Effectiveness of Preservatives Used in Meat Production." Works of Georgian Technical University, no. 1(519) (March 29, 2021): 11–19. http://dx.doi.org/10.36073/1512-0996-2021-1-11-19.

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In order to store meat products for a long period of time, to maintain their quality and safety, meat producing companies use preservatives and antioxidants, which prove to be quite effective. However, they constitute some threat for the consumer. Various types of preservatives are used in meat processing companies in Georgia: “BOMBAL® ASC Super“, „BAKSOLAN-4”, “Standard Conservative”, “Standard Conservative Plus” and others. All of them represent a complex additive obtained through a chemical synthesis. For example, “BOMBAL ACS SUPER” is a mixture of three chemicalcompounds: Sodium Pyrosulphi
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Prajakta N. Dongare, Tejashri B. Kadu, Ashish L. Pohane, Sachin J. Dighade, and Priyadarshani G. Patil. "Review on Pharmacognosy, phytochemistry and pharmacological activity of Taraxacum officinale (Dandelion plant)." World Journal of Advanced Research and Reviews 12, no. 2 (2021): 212–118. http://dx.doi.org/10.30574/wjarr.2021.12.2.0570.

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Taraxacum officinale (dandelion), a member of the Asteraceae family, commonly found in the temperate zone of the Northern hemisphere, is the perennial herb, forming a rosette leaf, golden yellow flowers that bloom year round. Dandelion leaves, roots and flowers is used in many traditional and modern herbal medicinal systems. On phytochemical investigation, Dandelion herb contains one or more vital phytochemical constituents. Similarly Among the most important compounds in dandelion Contains sesquiterpene lactones which is a bitter element, principally contains taraxacin and taraxacerin, which
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Ray, Arunabha, Kavita Gulati, and Peter Henke. "Stress Gastric Ulcers and Cytoprotective Strategies: Perspectives and Trends." Current Pharmaceutical Design 26, no. 25 (2020): 2982–90. http://dx.doi.org/10.2174/1381612826666200521143203.

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Stress gastric ulceration is a clinical condition leading to morbidity/mortality and complex etiopathological factors are involved. Pharmacotherapy of such gastric mucosal lesions is not consistent and novel strategies are being explored. Targeting gastrointestinal factors have showed equivocal results and there is a possibility of involvement of extra-gastrointestinal factors. Stress is a highly interactive biological response in which the brain plays a key role. The involvement of brain substrates like the limbic system (amygdala, cortex, hippocampus) and behavioral traits has been investiga
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Hamed, Eman M., Mohamed Hussein Meabed, Usama Farghaly Aly, and Raghda R. S. Hussein. "Recent Progress in Gene Therapy and Other Targeted Therapeutic Approaches for Beta Thalassemia." Current Drug Targets 20, no. 16 (2019): 1603–23. http://dx.doi.org/10.2174/1389450120666190726155733.

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Beta-thalassemia is a genetic disorder characterized by the impaired synthesis of the betaglobin chain of adult hemoglobin. The disorder has a complex pathophysiology that affects multiple organ systems. The main complications of beta thalassemia are ineffective erythropoiesis, chronic hemolytic anemia and hemosiderosis-induced organ dysfunction. Regular blood transfusions are the main therapy for beta thalassemia major; however, this treatment can cause cardiac and hepatic hemosiderosis – the most common cause of death in these patients. This review focuses on unique future therapeutic interv
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Kulkarni, Nikhilesh, Jayshree Narwade, Rachana Pachori, and Prithviraj Sadar. "Microbial quality of herbal juices sold at sport complex in Washim." International Journal of Research in Medical Sciences 5, no. 11 (2017): 4946. http://dx.doi.org/10.18203/2320-6012.ijrms20174950.

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Background: Herbal juices are gaining global attention due to their medicinal properties, nutritive and antioxidant activity. They are frequently consumed by the people of all age groups in the form of health drinks. However, many outbreaks of human infections have been reported to be associated with the consumption of contaminated herbal juices. Hence, microbial quality assessment of herbal juices is utmost important.Methods: The present study was undertaken to detect the existence of enteric pathogens as well as coliforms in the herbal juices sold at sport complex in Washim city area. The an
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LUPANOVA, Irina A., Praskovya G. MIZINA, Nikolay I. SIDELNIKOV, and Alexander S. GULENKOV. "SPECIFIC ACTIVITY OF BIOLOGICALLY ACTIVE COMPLEX IN LIQUID HERBAL DRUG EXTRACTS, STUDIED UNDER DIFFERENT DRYING CONDITIONS." Periódico Tchê Química 16, no. 31 (2019): 484–90. http://dx.doi.org/10.52571/ptq.v16.n31.2020.490_periodico31_pgs_484_490.pdf.

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The aim of this study was to evaluate the influence of different methods of extraction solvents removal from liquid herbal drugs extracts on their pharmacological activity (immunomodulating, adaptogene, antioxidant and antibacterial). The authors used specific enzyme biotest systems in vitro based on key enzymes of antioxidant protection system - glutathione reductase and catalase, as well as on limiting enzyme of phagocytosis terminal phase – NADPH-oxidase, that allow the researchers to identify adaptogene, antioxidant, antibacterial and immunomodulating BAS activity and to estimate possible
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Kim, Dae-Hyung, Nak-Yun Sung, Jeong-Soo Kim, Jae-Hun Kim, Yeoung-Jung Hwang, and Ju-Woon Lee. "Alcohol metabolizing and antioxidant activities of complex herbal extracts from medicinal plants." Food Science and Biotechnology 20, no. 5 (2011): 1337–45. http://dx.doi.org/10.1007/s10068-011-0184-5.

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Studzińska-Sroka, Elżbieta, Agnieszka Galanty, Anna Gościniak, et al. "Herbal Infusions as a Valuable Functional Food." Nutrients 13, no. 11 (2021): 4051. http://dx.doi.org/10.3390/nu13114051.

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Herbal infusions are an underestimated and easy to intake a source of biologically active natural compounds (polyphenols), which, in the dissolved form, are more easily absorbed. Therefore, this study aimed to assess the potential of herbal infusions as a functional food to reduce postprandial hyperglycemia (inhibition of α-amylase and α-glucosidase) and to reduce the effects of increased blood glucose level (antioxidant effect-DPPH, CUPRAC, and Fe2+ chelating assays, as well as anti-inflammatory activity-inhibition of collagenase). We showed that polyphenols are present in the examined aqueou
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Sharma, Ramesh K., Maria Micali, Alessandra Pellerito, et al. "Studies on the Determination of Antioxidant Activity and Phenolic Content of Plant Products in India (2000–2017)." Journal of AOAC INTERNATIONAL 102, no. 5 (2019): 1407–13. http://dx.doi.org/10.1093/jaoac/102.5.1407.

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Abstract Background: Ayurveda, the traditional Indian therapeutic system, involves herbs and spices as drug ingredients and a kind of food intake regulation. The health and curative aspects of plant products are often ascribed to their antimicrobial and antioxidant activities (AA). However, it seems somewhat possible to correlate the AA of herbal extracts or plant isolates with their phenolic contents (PC). Objective: Indian researchers have carried out some tests for the determination of AA and PC of plant products that are worth mentioning. Methods: Among the herbal analysis techniques, the
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Gyawali, Rajendra, Nira Paudel, Sahana Shrestha, and Ashok Silwal. "Formulation and Evaluation of Antibacterial and Antioxidant Polyherbal Lotion." Journal of Institute of Science and Technology 21, no. 1 (2016): 148–56. http://dx.doi.org/10.3126/jist.v21i1.16067.

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There is increased scientific evidence that plants possess a vast and complex arsenal of active ingredients which have the ability to calm or smooth the skin as well as restore actively, heal and protect the skin. The present work deals with the development and evaluation of the poly herbal lotion containing Trigonella foenum-graecum, Citrus lemon, Matricaria chamomilla and Cymbopogon citrates. Different types of formulations oil in water (O/W) herbal lotions namely F1 to F13 were formulated by incorporating different concentrations of stearic acid and Triethanolamine. Formulation of Triethano
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Kalita, Bhupen, and Bhargab Nath Patwary. "Formulation and in vitro Evaluation of Hesperidin-Phospholipid Complex and its Antioxidant Potential." Current Drug Therapy 15, no. 1 (2020): 28–36. http://dx.doi.org/10.2174/1574885514666190226155933.

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Background: The recent trend of herbal drug delivery has been focused on developing novel drug delivery carriers to address problems related to solubility, oral bioavailability, skin permeation and stability. The phyto-phospholipid complex (phytosomes®) technology has been used to overcome the problems associated with many conventional herbal extracts. Aim: The present work aimed to formulate phospholipid-complex of the flavanoid Hesperidin to enhance its dissolution leading to enhanced oral bioavailability. Method: The complex was prepared by refluxing various molar ratios of hesperidin and P
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Hutasoit, Hostalige, Dionysius Joseph Djoko, Sutiman Sumitro, and Simon Bambang Widjanarko. "Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook F.) as Low Molecular Weight Scavenging Antioxidant: A Computational Study." Journal of Tropical Life Science 11, no. 3 (2021): 267–73. http://dx.doi.org/10.11594/jtls.11.03.02.

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Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway. This study was designed by ultra-performance liquid chromatography (UPLC) coupled with ultra-high-resolution time of flight-mass spectrometry detector (TOF-MS), docking (Pyrex and Discovery Studio 2016 Client) and pharmacokinetic properties predictio
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Bradūnaitė, Rūta, Laima Leonavičienė, Laimis Akramas, et al. "The effect of complex herbal extract and methotrexate on suppressing adjuvant arthritis in rats." Veterinarski arhiv 91, no. 4 (2021): 411–25. http://dx.doi.org/10.24099/vet.arhiv.0973.

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The present study evaluated the therapeutic benefits of complex herbal preparation named CBMDS, consisting of turmeric (Curcuma longa), Boswellia (Boswellia serrata), Methylsulphonylmethane, Devil’s Claw (Harpagophytum procumbens) and Silymarin, using it in combination with methotrexate, in order to suppress adjuvant arthritis in rats, and to attenuate methotrexate-induced liver damage. Adjuvant arthritis was induced in 28 rats by a single subplantar injection of complete Freund’s adjuvant (0.1 mL) into the left hind paw. The animals were divided into four groups (with seven animals in each).
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Shen, Jie, Kai Yang, Caihua Sun, and Minxia Zheng. "Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection." Acta Pharmaceutica 64, no. 3 (2014): 325–34. http://dx.doi.org/10.2478/acph-2014-0027.

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Abstract Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, protocatechuic acid and their metabolites in rat serum may contribute to the efficacy of SMI. Assessment of antioxidant properties indicated that differences in the composition of serum
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Quijano-Avilés, Maria, Ivan Chóez-Guaranda, Rafael Viteri, Ana Barragán-Lucas, Daynet Sosa, and Patricia Manzano. "Effect of Cocoa Bean Shell Addition on Metabolite Profile and Antioxidant Activity of Herbal Infusions." International Journal of Food Science 2021 (May 6, 2021): 1–8. http://dx.doi.org/10.1155/2021/9915797.

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Cocoa bean shell (CBS) is a by-product with aromatic characteristics that can enhance the aroma and bioactivity of herbal infusions. This study was aimed to determine the effect of the addition of cocoa bean shell on the metabolite profile and antioxidant activity of infusions made with Ilex guayusa and Vernonanthura patens and their mixtures. Metabolite profile was analyzed by gas chromatography–mass spectrometry combined with multivariate analysis. Total polyphenol content and flavonoids were determined by the Folin-Ciocalteu method and by the flavonoid-AlCl3 complex, respectively. Antioxida
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Ma, Zheng Feei, Hongxia Zhang, Sue Siang Teh, et al. "Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action." Oxidative Medicine and Cellular Longevity 2019 (January 9, 2019): 1–9. http://dx.doi.org/10.1155/2019/2437397.

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Goji berries (Lycium fruits) are usually found in Asia, particularly in northwest regions of China. Traditionally, dried goji berries are cooked before they are consumed. They are commonly used in Chinese soups and as herbal tea. Moreover, goji berries are used for the production of tincture, wine, and juice. Goji berries are high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. Therefore, the aim of the review was to focus on the bioactive compounds and pharmacologi
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Alam, Sanjar, Deepti Katiyar, Richa Goel, Amita Vats, and Ashu Mittal. "Role of herbals in cancer management." Journal of Phytopharmacology 2, no. 6 (2013): 46–51. http://dx.doi.org/10.31254/phyto.2013.2608.

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Herbal medicines have a vital role in the prevention and treatment of cancer. A great deal of pharmaceutical research done in technologically advanced countries like USA, Germany, France, Japan and China has considerably improved quality of the herbal medicines used in the treatment of cancer. With advanced knowledge of molecular science and refinement in isolation & structure elucidation techniques, we are in a much better position to identify various anticancer herbs and develop the remedy that might cure cancer. The therapeutic effect of anticancer herbs is executed by inhibiting cancer
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Korkmazov, M. Yu, A. V. Solodovnik, A. M. Korkmazov, and M. A. Lengina. "Prospects for using herbal preparation in combination with physical methods in complex therapy of chronic adenoiditis." Meditsinskiy sovet = Medical Council, no. 18 (December 1, 2021): 19–27. http://dx.doi.org/10.21518/2079-701x-2021-18-19-27.

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Introduction. Importance of the search effective methods of treating chronic adenoiditis in children is associated with a high incidence and risk of developing complications. Treatment of chronic adenoiditis are described in the literature, but the advantages of any of them are inconclusive, which leads to the search for additional more progressive methods.Objective. To increase the effectiveness of the treatment of chronic adenoiditis using complex therapy of non-drug methods in combination with the herbal preparation Tonsilgon N.Materials and methods. Biochemical changes in lymphoid tissue w
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Alagawany, Mahmoud, Shaaban S. Elnesr, Mayada R. Farag, et al. "Use of Licorice (Glycyrrhiza glabra) Herb as a Feed Additive in Poultry: Current Knowledge and Prospects." Animals 9, no. 8 (2019): 536. http://dx.doi.org/10.3390/ani9080536.

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Supplementation of livestock and poultry diets with herbal plants containing bioactive components have shown promising reports as natural feed supplements. These additives are able to promote growth performance and improve feed efficiency, nutrient digestion, antioxidant status, immunological indices, and poultry health. Several studies have used complex herbal formulas with the partial inclusion of licorice. However, the individual use of licorice has been rarely reported. The major problem of the poultry industry is the epidemiological diseases, mainly confined to the respiratory, digestive,
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Sansone, Francesca, Tiziana Esposito, Maria Lauro, et al. "Application of Spray Drying Particle Engineering to a High-Functionality/Low-Solubility Milk Thistle Extract: Powders Production and Characterization." Molecules 23, no. 7 (2018): 1716. http://dx.doi.org/10.3390/molecules23071716.

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Many natural compounds having antioxidant and anti-inflammatory activity are a potential target for new therapies against chronic inflammatory syndromes. The oral administration of functional herbal supplements may become a prevention strategy or therapy adjuvant for susceptible patients. A case study is our milk thistle (Silybum marianum) extract rich in silymarin complex. A water-soluble microencapsulated powder system was developed by a spray drying technique to improve the poor silymarin bioactivity after oral administration. Sodium carboxymethylcellulose (NaCMC) was employed as coating/sw
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Mehla, Jogender, Pooja Gupta, Monika Pahuja, Deepti Diwan, and Diksha Diksha. "Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment." Brain Sciences 10, no. 12 (2020): 964. http://dx.doi.org/10.3390/brainsci10120964.

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Cognitive impairment, associated with ageing, stress, hypertension and various neurodegenerative disorders including Parkinson’s disease and epilepsy, is a major health issue. The present review focuses on Alzheimer’s disease (AD), since it is the most important cause of cognitive impairment. It is characterized by progressive memory loss, language deficits, depression, agitation, mood disturbances and psychosis. Although the hallmarks of AD are cholinergic dysfunction, β-amyloid plaques and neurofibrillary tangle formation, it is also associated with derangement of other neurotransmitters, el
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Jung, Woo-Sang, Seungwon Kwon, Seung-Yeon Cho, et al. "The Effects ofChunghyul-Dan(A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2601740.

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Chunghyul-dan(CHD) is a herbal complex containing 80% ethanol extract and is composed ofScutellariae Radix,Coptidis Rhizoma,Phellodendri Cortex,Gardeniae Fructus, andRhei Rhizoma. We have published several experimental and clinical research articles on CHD. It has shown antilipidemic, antihypertensive, antiatherosclerotic, and inhibitory effects on ischemic stroke recurrence with clinical safety in the previous studies. The antilipidemic effect of CHD results from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and pancreatic lipase-inhibitory activity. The antihypertensive effect li
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Tungmunnithum, Duangjai, Samantha Drouet, Laurine Garros, Jose Manuel Lorenzo, and Christophe Hano. "Flavonoid Profiles and Antioxidant Potential of Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum, a New Species from the Genus Monochoria C. Presl." Antioxidants 11, no. 5 (2022): 952. http://dx.doi.org/10.3390/antiox11050952.

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Plants of the genus Monochoria have long been utilized in food, cosmetics, and traditional herbal treatments. Thailand has the highest species diversity of this genus and a new member, Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum has been recently described. This plant is called “Siam Violet Pearl” as a common name or “Khimuk Si Muang Haeng Siam” as its vernacular name with the same meaning in the Thai language. Despite their importance, little research on Monochoria species has been conducted. This study, thus, provides the results to fill in this gap by: (i) determining
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Zhao, Li-Juan, Song-Lin Yang, Wen Jin та ін. "Host-Guest Inclusion Systems of Morin Hydrate and Quercetin with Two Bis(β-cyclodextrin)s: Preparation, Characterization, and Antioxidant Activity". Australian Journal of Chemistry 72, № 6 (2019): 440. http://dx.doi.org/10.1071/ch18580.

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The inclusion complexation behaviour of morin hydrate (MH) and quercetin (QCT) with the two amide-bridged bis(β-cyclodextrin (β-CD))s, 1 and 2, was investigated in both solution and the solid state. The inclusion complexations were characterised by proton nuclear magnetic resonance, 2D rotating-frame Overhauser effect spectroscopy, X-ray powder diffraction, infrared spectroscopy and scanning electron microscopy. Ultraviolet titration analysis indicated that 1 and 2 form 1:1 molar stoichiometry inclusion complexes with MH and QCT, and the data obtained showed that 2 with two guests has a higher
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Korochinsky, A. V., Ja V. Daironas, V. V. Vernikovsky, I. N. Zilfikarov, E. F. Stepanova, and M. V. Chernikov. "Actual Aspects of Medical Application of Black Nut – Juglans Nigra L. (Review)." Drug development & registration 8, no. 3 (2019): 21–28. http://dx.doi.org/10.33380/2305-2066-2019-8-3-21-28.

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Introduction. Herbal drugs of black walnut (Juglans nigra L.) are not registered on the territory of the Russian Federation at the present time. However, the State Register of Medicinal Products includes an extract of unripe fruits of a related species walnut (Juglans regia L.) «Yuglanex» (made in Russia) and the complex herbal drug «Tonsilgon» (made in Germany). A number of biologically active food supplements from black walnut raw materials have been registered by Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. They are an additional source of phen
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Lu, Guanyu, Zhuoting Liu, Xu Wang, and Chunling Wang. "Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review." Foods 10, no. 5 (2021): 1030. http://dx.doi.org/10.3390/foods10051030.

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As an ancient Chinese herbal medicine, Panax ginseng C.A. Meyer (P. ginseng) has been used both as food and medicine for nutrient supplements and treatment of human diseases in China for years. Fatigue, as a complex and multi-cause symptom, harms life from all sides. Millions worldwide suffer from fatigue, mainly caused by physical labor, mental stress, and chronic diseases. Multiple medicines, especially P. ginseng, were used for many patients or sub-healthy people who suffer from fatigue as a treatment or healthcare product. This review covers the extract and major components of P. ginseng w
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Trembach, O. I., and N. V. Khokhlenkova. "The theoretical substantiation of the composition of a wound-healing ointment with active components of plant origin." News of Pharmacy 103, no. 1 (2022): 48–54. http://dx.doi.org/10.24959/nphj.22.81.

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Aim. To theoretically substantiate the composition of a wound healing ointment with active substances of plant origin for the therapy in the second and third phases of the wound process. Materials and methods. The study object was the generalization and analysis of scientific literature data on the use of medicinal plants in the treatment of the wound process. Results and discussion. Based on the analysis of scientific literature data on the chemical composition and pharmacological properties of medicinal plants used in the treatment of the wound process, the expediency of using the lipophilic
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Kim, Ji Hoon, Eun Ju Jung, Yun Jung Lee, Chul Young Kim, and Je-Seung Jeon. "Application of Linear Gradient Solvent System in Centrifugal Partition Chromatography Facilitating Bioassay-Guided Fractionation of Yongdamsagan-Tang, Traditional Oriental Decoction." Evidence-Based Complementary and Alternative Medicine 2021 (October 31, 2021): 1–11. http://dx.doi.org/10.1155/2021/7552169.

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As important pharmaceutical resources, traditional herbal medicines retain continuous attention. To do that, isolation and identification of bioactive molecules from traditional herbal decoction are important. However, conventional fractionation through octadecyl silica column faces irreversible sample adsorption that causes a bias in bioactivity assessment. However, liquid-liquid chromatographic system suffers tedious K value calculation as well as insufficient capacity in separation power when crude extract composed of widely ranging polarities. Here, we developed a comprehensive linear grad
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Tungmunnithum, Duangjai, Samantha Drouet, and Christophe Hano. "Phytochemical Diversity and Antioxidant Potential of Natural Populations of Nelumbo nucifera Gaertn. throughout the Floristic Regions in Thailand." Molecules 27, no. 3 (2022): 681. http://dx.doi.org/10.3390/molecules27030681.

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Asian lotus has long been consumed as a food and herbal drug that provides several health benefits. The number of studies on its biological activity is significant, but research at the population level to investigate the variation in phytochemicals and biological activity of each population which is useful for a more efficient phytopharmaceutical application strategy remains needed. This present study provided the frontier results to fill-in this necessary gap to investigating the phytopharmaceutical potential of perianth and stamen, which represent an important part for Asian traditional medi
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Zakharova, I. N., I. V. Berezhnaya, and S. V. Shishkina. "Chronic constipation combined with biliary tract dysfunction in children: comorbidity or clinical regularity?" Medical Council, no. 17 (November 24, 2019): 130–36. http://dx.doi.org/10.21518/2079-701x-2019-17-130-136.

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Functional disorders of the gastrointestinal tract (GIT) are a common problem in children. The Roman IV criteria adopted in 2016, devoted to the problem of constipation and biliary tract dysfunction in children are developed in accordance with age and are idendoitified by the letter code. This article presents data on the correspondence of the Roman IV criteria and ICD-10 in the combined problem of constipation and biliary tract dysfunction in children. The development of upper gastrointestinal tract pathology caused by increased intracavitary pressure associated with impaired colon motility (
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36

Romanyuk, Anna A., and Dmitry V. Moiseev. "Senna leaves: component composition, pharmacological properties, standardization." Человек и его здоровье 24, no. 2 (2021): 53–65. http://dx.doi.org/10.21626/vestnik/2021-2/07.

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Objective: generalization and analysis of scientific data on the component composition, pharmacological properties and standardization of senna leaves. Materials and methods. The article provides an overview of scientific publications in the journals of the search platforms Scopus and PubMed, as well as the databases of the Russian Science Citation Index. The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers of Medicines of the Republic of Belarus, the Russian Federation and the Republic of Kazakhstan using content analysis, compari
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Thakur, Kumud Ranjan, S. R. Padmadeo, and Vikash Kumar. "Evaluation of anti-oxidative properties of Tinosporacordifoliain Alloxan induced diabetic Wistar rats." Biomedicine 41, no. 2 (2021): 421–26. http://dx.doi.org/10.51248/.v41i2.1050.

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Introduction and Aim: Type 2 Diabetes is a complex heterogenous disorder with marked hyperglycemia, reduced insulin sensitivity, increased oxidative stress, and altered carbohydrate, fat and protein metabolism. Increased oxidative stress is a key factor for the reduced pancreatic ? cell arose due to prolonged hyperglycemia. The present investigation admits ethanolic extract of Tinosporacordifolia (250mg/kg/body weight) as a potent antihyperglycemic agent as well as antioxidant.
 
 Materials and methods: Wistar norvegicus rats of 180-200 gm were involved in the present study divided i
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Chen, Yaqin, Yu Kong, Qili Wang та ін. "Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma". Journal of Immunology Research 2021 (28 червня 2021): 1–13. http://dx.doi.org/10.1155/2021/8029963.

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Background. Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, we explored the anti-inflammatory and antioxidant effects and provided the mechanistic insights into the activity of schisandrin B in a mouse model of ovalbumin- (OVA-) induced allergic asthma. Methods. Male BALB/c mice were sensitized and challenged with OVA to induce asthma and treated with various
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Serebryakova, I. Yu, T. I. Garashchenko, A. O. Kuznetsov, and A. O. Akhinyan. "Application of mucosecretolytics of plant origin in otorinolaryngology." Meditsinskiy sovet = Medical Council, no. 6 (May 12, 2021): 133–37. http://dx.doi.org/10.21518/2079-701x-2021-6-133-137.

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In modern otorhinolaryngology the use of herbal remedies, so-called clinical homeopathy, is widely used both as a basic and as part of complex therapy. A special place among this category belongs to medicines with secretolytic and mucolytic properties. This is due to the developed mucociliary system of the mucous membranes of the upper respiratory tract, which primarily suffers in acute and chronic inflammatory diseases. Most chemical mucoactive preparations have only one of the three mucosecretolytic effects and have a large number of contraindications. Herbal preparations, such as those cont
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Zhang, Taojing, Yanbin Gao, Yanbin Gong, et al. "Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/8176089.

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Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins. Tang-luo-ning mitigated STZ-induced diabetic symptoms and blood glucose lev
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Jung, Eunsun, Hyun Kyoung Cho, Yoon Sik Kim, Ho Ryong Yoo, and In Chan Seol. "Antioxidant and Anti-dyslipidemic Effect of Artemisiae iwayomogii Herba, Curcumae longae Radix, and Plantaginis Semen Complex Extract(ACP) on HepG2 Cells." Journal of Physiology & Pathology in Korean Medicine 32, no. 1 (2018): 13–23. http://dx.doi.org/10.15188/kjopp.2018.02.32.1.13.

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Ishan Dubey, Manmeet Singh Saluja, Ritu M Gilhotra, and Mahavir Chhajed. "Evaluation of Polyherbal Anticancer Tablets: A Review." Journal of Pharmaceutical Technology, Research and Management 6, no. 1 (2018): 67–79. http://dx.doi.org/10.15415/jptrm.2018.61006.

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Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation wit
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Mizernitskiy, Yu L., N. L. Dorovskaya, and I. M. Melnikova. "Prospects for the drug use based on common ivy for bronchopulmonary pathology in childhood." Meditsinskiy sovet = Medical Council, no. 17 (November 1, 2021): 122–27. http://dx.doi.org/10.21518/2079-701x-2021-17-122-127.

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Respiratory diseases persistently lead in the structure of general morbidity in both children and adolescents. Acute respiratory infections are the most common among them. Interest of pediatricians to phytotherapy is not accidental and is due to the fact that it has a mild therapeutic effect, enhances the effectiveness of complex therapy, has few side effects. Of particular interest are herbal remedies containing ivy extract (Hedera helix), the active ingredients are mainly found in ivy leaves, they are biologically active substances: Triterpene saponins, glycosides, also contain carbohydrates
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Rutkowska, Magdalena, Monika Anna Olszewska, Joanna Kolodziejczyk-Czepas, Pawel Nowak, and Aleksandra Owczarek. "Sorbus domestica Leaf Extracts and Their Activity Markers: Antioxidant Potential and Synergy Effects in Scavenging Assays of Multiple Oxidants." Molecules 24, no. 12 (2019): 2289. http://dx.doi.org/10.3390/molecules24122289.

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Sorbus domestica leaves are a traditionally used herbal medicine recommended for the treatment of oxidative stress-related diseases. Dry leaf extracts (standardized by LC-MS/MS and LC-PDA) and nine model activity markers (polyphenols), were tested in scavenging assays towards six in vivo-relevant oxidants (O2•−, OH•, NO•, H2O2, ONOO−, HClO). Ascorbic acid (AA) and Trolox (TX) were used as positive standards. The most active extracts were the diethyl ether and ethyl acetate fractions with activities in the range of 3.61–20.03 µmol AA equivalents/mg, depending on the assay. Among the model compo
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Zhukova, A. G., L. G. Gorokhova, A. S. Kazitskaya, T. K. Yadykina, N. N. Mikhailova, and Yu V. Arkhipenko. "Adaptogenic correction of free radical brain damage in subchronic exposure to sodium fl uoride." Russian Journal of Occupational Health and Industrial Ecology, no. 6 (July 10, 2020): 381–86. http://dx.doi.org/10.31089/1026-9428-2020-60-6-381-386.

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Introduction. Fluorine compounds in small doses, but with prolonged exposure, cause various disorders in organs at the cellular and molecular levels. Activation of free-radical processes plays an important role in the damaging eff ect of fl uorides. Th erefore, one of the most eff ective ways to limit fl uorine-induced damage is to directly aff ect free-radical processes using herbal preparations with antioxidant properties.The aim of the study is to study the eff ect of a dihydroquercetin-based drug on the activity of free radical processes in brain tissue under subchronic exposure to sodium
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Li, Gang, Wei Zhou, Xiurong Zhao, and Ying Xie. "In Silico Molecular Docking and Interaction Analysis of Traditional Chinese Medicines Against SARS-CoV-2 Receptor." Natural Product Communications 16, no. 5 (2021): 1934578X2110150. http://dx.doi.org/10.1177/1934578x211015030.

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The novel coronavirus, 2019-nCoV, has led to a major pandemic in 2020 and is responsible for more than 2.9 million officially recorded deaths worldwide. As well as synthetic anti-viral drugs, there is also a need to explore natural herbal remedies. The Traditional Chinese Medicines (TCMs) system has been used for thousands of years for the prevention, diagnosis, and treatment of several chronic diseases. In this paper, we performed an in silico molecular docking and interaction analysis of TCMs against SARS-CoV-2 receptor RNA-dependent RNA polymerase (RdRp). We obtained the 5 most effective pl
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Z, Mukasa-Tebandeke, I., Karume, I, Ssebuwufu, J, Wasajja, H. Z, and Nankinga, R. M. "Comparison of Antioxidant, Flavonoid and Polyphenol Content of Three Selected Solanaceae Genera from Kigezi, Southwest Uganda." Scholars International Journal of Chemistry and Material Sciences 5, no. 4 (2022): 40–60. http://dx.doi.org/10.36348/sijcms.2022.v05i04.001.

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Solanaceae is family of plants widely used in food, sauce and herbal medicine because its members are rich in carbohydrates, proteins, fats, vitamins, mineral salts and other trace and essential nutrients like phenols and flavonoids that retard degenerative diseases and stress. Knowledge on purposeful use of solanaceae in food and medicine in Uganda is low. Aqueous extracts of dry leaves of three selected solanum genera growing in Kabale were compared for their polyphenol and flavonoid contents and antioxidant properties. Total polyphenol (TPC) and total flavonoid (TFC) contents were determine
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Cao, Ke, Weiqiang Lv, Xuyun Liu та ін. "Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade". Nutrients 12, № 1 (2020): 164. http://dx.doi.org/10.3390/nu12010164.

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Hyperlipidemia is associated with metabolic disorders, but the detailed mechanisms and related interventions remain largely unclear. As a functional food in Asian diets, Herba houttuyniae has been reported to have beneficial effects on health. The present research was to investigate the protective effects of Herba houttuyniae aqueous extract (HAE) on hyperlipidemia-induced liver and heart impairments and its potential mechanisms. Male C57BL/6J mice were administered with 200 or 400 mg/kg/day HAE for 9 days, followed by intraperitoneal injection with 0.5 g/kg poloxamer 407 to induce acute hyper
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Смойловська, Г. П., О. О. Малюгіна, О. К. Єренко та Т. В. Хортецька. "Study of the content of carbonic acids in the herbs of Сapsella bursa-pastoris (L.) Medik". Farmatsevtychnyi zhurnal, № 1 (23 лютого 2022): 86–93. http://dx.doi.org/10.32352/0367-3057.1.22.08.

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Carboxylic acids are key compounds that play an important role in metabolism. They activate the endocrine glands, affect human immune status, have antioxidant, antimicrobial and anti-inflammatory effects. Plants rich in carboxylic acids are recommended for the prevention of various diseases. A promising source of biologically active substances are Capsella bursa-pastoris, which has a significant content of vitamins, flavonoids, organic, hydroxycinnamic, fatty acids, macro-and micronutrients, tannins. Capsella bursa-pastoris is known for such healing properties as wound healing, antimicrobial,
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Saliuk, O. D., P. H. Gerasimchuk, L. O. Zaitsev, et al. "Application of Plant-Based Preparations in a Comprehensive Treatment of Inflammatory Periodontal Diseases." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (2021): 38–44. http://dx.doi.org/10.26693/jmbs06.05.038.

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In this article the review of foreign and domestic literary sources, which are devoted to the actual problem of modern dentistry – the treatment of inflammatory diseases of periodontal tissues: gingivitis and periodontitis are presented. The complex approach to their treatment involves the appointment of a significant amount of pharmacotherapeutic drugs. Therapeutic failures and iatrogenic complications have led to the fact that today the interests of doctors and population to medicinal products significantly increased. The purpose of the study is to analyze the data of scientific literature o
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