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Relevant bibliographies by topics / Complex physiology / Dissertations / Theses

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Dissertations / Theses on the topic 'Complex physiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Dave, Emma. "The physiology of the Escherichia coli pyruvate dehydrogenase complex." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364242.

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2

Sim, Jae Hoon. "Imaging, physiology, and biomechanics of the malleus-incus complex /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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3

Ollivier, Julien. "Scalable methods for modelling complex biochemical networks." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104586.

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In cells, complex networks of interacting biomolecules process both environmental and endogenous signals to control gene expression and other cellular processes. This poses a challenge to researchers who attempt to develop mathematical and computational models of biochemical networks that reflect this complexity. In this thesis, I propose methods that help manage complexity by exploiting the finding that, as for other biological systems, cellular networks are characterized by a modularity that appears at all levels of organization.The first part of this work focuses on the modular properties o

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4

Caudron, Quentin. "Neuronal computation on complex dendritic morphologies." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/57056/.

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When we think about neural cells, we immediately recall the wealth of electrical behaviour which, eventually, brings about consciousness. Hidden deep in the frequencies and timings of action potentials, in subthreshold oscillations, and in the cooperation of tens of billions of neurons, are synchronicities and emergent behaviours that result in high-level, system-wide properties such as thought and cognition. However, neurons are even more remarkable for their elaborate morphologies, unique among biological cells. The principal, and most striking, component of neuronal morphologies is the dend

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5

Wells, Cathy Clarke. "The complex spatial topography of visual attention : behavior and physiology /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174692.

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6

Florman, Jeremy T. "Neuroendocrine Modulation of Complex Behavior and Physiology in C. elegans." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1109.

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To survive, animals must adapt to a complex and challenging world in a way that is flexible and responsive, while maintaining internal homeostasis. Neuromodulators provide a means to systemically alter behavioral or physiological state based on intrinsic or extrinsic cues, however dysregulated neuroendocrine signaling has negative consequences for fitness and survival. Here I examine neuroendocrine function and dysfunction using the escape response in Caenorhabditis elegans. The RFamide neuropeptide FLP-18 is a co-transmitter with the monoamine tyramine and functions both synergistically and a

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7

Burgess, Alexandra Jacquelyn. "The variable light environment within complex 3D canopies." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/38967/.

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With an expanding population and uncertain consequences of climate change, the need to both stabilise and increase crop yields is important. The relationship between biomass production and radiation interception suggests one target for improvement. Under optimal growing conditions, biomass production is determined by the amount of light intercepted and the efficiency with which this is converted into dry matter. The amount of light at a given photosynthetic surface is dependent upon solar movement, weather patterns and the structure of the plant, amongst others. Optimising canopy structure pro

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8

Jones, Benjamin R. "Engineering a fluorescent calmodulin for use in complex models of cardiac physiology." Connect to resource, 2009. http://hdl.handle.net/1811/37210.

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9

Hughes, Ruth. "Serpentine tolerance in the Mimulus guttatus complex." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286489.

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10

Stojanovic, Marina. "Role BAP31 complex at the endoplasmic reticulum in normal cell physiology and apoptosis." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102730.

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The endoplasmic reticulum (ER) plays a vital role in synthesis, folding and sorting of newly synthesized secretory cargo proteins. Quality control mechanism in the ER is a key regulator of this process, which separates correctly folded proteins from immature or misfolded secretory proteins, and ultimately retains and disposes the latter before they can exit the ER. Numerous diseases have been associated with defects in the regulation of the egress of the nascent membrane proteins out of ER to the cell surface. BAP31, a polytopic integral membrane protein at the ER, has been implicated as a put

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11

Schmitt, Daniel T. "Time series analysis of real-world complex systems - climate, finance, proteins, and physiology." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60656.

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12

Mahdee, Anas Falah. "Physiology and pathophysiology of the dentine-pulp complex in response to dentine exposure." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3936.

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Therapies to promote pulp repair and regeneration after injury should be underpinned by a deep understanding of normal tissue behaviour, and cellular signalling mechanisms. The objectives of this work were to understand normal structure of the tooth and to identify changes in its cellular elements and their complex interactions in response to dentine exposure. Revisiting pulp structure and function with a range of contemporary techniques may formalize observations into new concepts of tooth physiology and pathophysiology, and reveal new opportunities for therapeutic intervention. Studies withi

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13

Wolf, Mary Caroline. "Neural and behavioral responses to complex stimuli using crayfish as a model system." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1130864221.

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14

Davies, Julie Katrina. "An investigation into the anatomy and physiology of the nucleus isthmi complex in quail." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/38280.

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15

Sengupta, Shomit. "The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57673.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The multi-component kinase mTOR complex 1 (mTORC 1) coordinates nutrient and growth factor inputs with numerous downstream processes including protein translation, autophagy, metabolism and cell growth. We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body postnatal growth similar to reduced caloric intake. We found that while feeding activated mTORC 1 in almost every tissue, there was variability i

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16

Teo, Ee Hiok. ""The morphology of the pineal complex in the scincid lizard, Tiliqua rugosa" /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09pht314.pdf.

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17

Tang, Haoran. "Scar/WAVE complex suppresses cell invasion and cancer cell transformation." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3633/.

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The mechanisms by which cancer cells hijack the actin cytoskeleton to invade and disseminate to distant sites of metastasis remains one of the great frontiers in cancer research. Many actin-regulating proteins have been identified to be important in cancer cell invasion and metastasis. However the role of a major actin assembly promoting complex, Scar/WAVE regulatory complex (WRC) in cancer cell invasion is poorly understood. WRC has a well-known motility-promoting role in 2D planar cell migration, but a recent study on human epithelial cancers suggests WRC may be anti-invasive in vivo. To inv

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18

Menke, Nathan. "A COMPUTATIONAL BIOLOGY APPROACH TO THE ANALYSIS OF COMPLEX PHYSIOLOGY: COAGULATION, FIBRINOLYSIS, AND WOUND HEALING." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2093.

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The birth of complexity research derives from the logical progression of advancement in the scientific field afforded by reductionist theory. We present in silico models of two complex physiological processes, wound healing and coagulation/fibrinolysis based on two common tools in the study of complex physiology: ordinary differential equations (ODE) and Agent Based Modeling (ABM). The strengths of these two approaches are well-suited in the analysis of clinical paradigms such as wound healing and coagulation. The complex interactions that characterize acute wound healing have stymied the d

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19

Ono, Santa Jeremy. "Major histocompatibility complex association of insulin-dependent diabetes in the BB rat." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74607.

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BB rats spontaneously develop an insulin-dependent diabetes mellitus strikingly similar to the syndrome observed in man. The disorder requires the presence of multiple susceptibility genes and unknown environmental factors. At least one susceptibility gene resides within the u haplotype of the rat major histocompatibility complex (RT1). Restriction fragment length polymorphism analysis of genomic DNA from rats generated from a series of intercrosses between diabetic BB rats and Buffalo rats (RT1$ sp{ rm b})$ demonstrated that animals heterozygous throughout the RT1 developed IDDM. A single dos

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20

Bishop, Clayton. "Biochemical and Structural studies of AAV-2 Rep68-AAVS1 complex assembly." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3511.

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Multiple DNA transactions are at the center of almost all processes regulating the AAV life cycle. A common feature shared by all transactions is the binding of the large AAV Rep proteins Rep78/Rep68 onto DNA sites harboring multiple GCTC repeats. AAV mediated site-specific integration is contingent upon the formation of a productive complex between Rep78/Rep68 and the AAVS1 site located at chromosome 19. In order to understand the mechanistic details of the initial assembly process we carried out equilibrium binding experiments of Rep68 and its individual domains with a 42-mer AAVS1 site. Res

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21

Fort, Loïc. "FAM49B : first negative regulator of the Scar/WAVE complex : from evolution to an in vivo analysis." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8673/.

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22

Sauer, Juergen. "Human skill maintenance in complex work environments : applications to extended spaceflight." Thesis, University of Hull, 1997. http://hydra.hull.ac.uk/resources/hull:8298.

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This thesis examines human performance under sub-optimal working conditions during work with complex and highly-automated process control systems. The operational context focuses on applications in extended spaceflight but the generic approach allows for generalisations beyond this target work environment The methodological approach is based on the use of a computerised multiple-task environment to carry out generic simulations of real work environments (micro-worlds) with a high level of ecological validity. For that purpose, a PC-based task. environment was developed to simulate the operatio

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23

Hoy, Jennifer Lyn 1981. "The Development of Excitatory Synapses and Complex Behavior." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12068.

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xi, 111 p. : ill. (some col.)<br>Excitatory glutamatergic synapses facilitate important aspects of communication between the neurons that govern complex forms of behavior. Accordingly, small differences in the molecular composition of glutamatergic synapses have been suggested to underlie neurodevelopment disorders, drive evolutionary changes in brain function and behavior, and enhance specific aspects of cognition in mammals. The appropriate development and later function of these structures in the adult involves the wellcoordinated activities of hundreds of molecules. Therefore, an important

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24

Sayegh, Camil E. "The role of the B cell receptor complex in avian B cell development dissected by retroviruses /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37621.

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During embryogenesis, B cell precursors that have undergone productive Ig V(D)J rearrangement are selected to expand in oligoclonal follicles of the bursa of Fabricius. Because Ig V(D)J recombination in chickens results in minimal diversity, diversity being generated instead by gene conversion in the follicles of the bursa of Fabricius, B cell precursors express a limited range of Ig specificities prior to colonization of the bursa. It has been proposed that recognition of endogenous ligands by this 'pre-diversified' B cell receptor is critical to the progression of normal B cell development.

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25

Sunu, Shawn Y. "MITOCHONDRIAL THERAPEUTICS DURING ISCHEMIA-REPERFUSION; MODULATION OF COMPLEX I: EFFECT OF METFORMIN." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3822.

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The modulation of the electron transport during ischemia-reperfusion has been shown to be protective. We hypothesized that metformin, a Complex I inhibitor, may exhibit characteristics of a pharmacological agent that could achieve long-term therapeutic intervention against ischemia-reperfusion injury. Mitochondria were harvested from adult male mice and incubated with or without metformin at 30oC for 15 minutes, while being shaken at 300 rpm. Metformin decreased Complex I oxidative phosphorylation and Complex I activity. However, metformin also increased injury and decreased the maximum membra

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26

Bauer, Eric Edmond. "Responses of cells of the dorsal nucleus of the lateral lemmniscus to species-specific and other complex sounds." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3035940.

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27

Song, Zhe. "Immunofluorescent approaches to investigate the mammalian target of rapamycin (mTOR) complex in human skeletal muscle." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6338/.

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The mammalian target of rapamycin (mTOR) complex is a key regulator of protein synthesis, with resistance exercise and protein ingestion both shown to increase mTOR activity in human skeletal muscle. It has recently been proposed that mTOR activity is regulated via its intracellular localization and protein complex interaction. However, no research to date has examined this process in human skeletal muscle. Accordingly, the aims of this thesis were to (1) develop immunofluorescent-based methodologies to study mTOR in human skeletal muscle, and (2) apply this approach to the study of mTOR in ac

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28

Siddiqui, Jalal K. "Modeling the response of troponin C to calcium in increasingly complex systems." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480258715871156.

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29

Smith, Cody Don. "Characterization of the LKB1-MO25-STRAD AMPKK Complex in Adult Mouse Skeletal Muscle." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2803.

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In liver tissue, the AMP-activated protein kinase kinase (AMPKK) complex was identified as the association of LKB1, MO25α/β, and STRADα/β proteins; however, this complex has yet to be characterized in skeletal muscle. In this report, we demonstrate the expression of the LKB1-MO25-STRAD AMPKK complex in adult skeletal muscle, confirm the absence of mRNA splice variants, and report the relative mRNA expression levels of these complex-forming proteins. To facilitate this characterization we used control (ctrl) and muscle-specific LKB1 knockout (LKB1-/-) mice. LKB1 detection in untreated ctrl and

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30

Liu, Zheng-Xian. "Antioxidant activity of Mn-salophen complex and its effects on antioxidant enzymes in Escherichia coli." Diss., Virginia Tech, 1994. http://hdl.handle.net/10919/40046.

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Mn-salophen complex with superoxide-scavenging activity was prepared from manganese(III) acetate dihydrate and salophen in ethanol. Visible absorption spectrum of the red-brown solution exhibited a broad absorption band at 430 - 450 nm with two shoulders between 500 and 600 nm which were absent with either salophen or manganic acetate alone. Titration of salophen with manganese(III) was consistent with a 1:1 Mn to salophen stoichiometry of the complex based on changes in the absorbance at 500 nm or of superoxide scavenging activity. The SOD-like activity of the complex in the xanthine-xanthine

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31

Bohara, Gyanendra. "Application of Statistical Physics in Human Physiology: Heart-Brain Dynamics." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1248449/.

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This dissertation is devoted to study of complex systems in human physiology particularly heartbeats and brain dynamics. We have studied the dynamics of heartbeats that has been a subject of investigation of two independent groups. The first group emphasized the multifractal nature of the heartbeat dynamics of healthy subjects, whereas the second group had established a close connection between healthy subjects and the occurrence of crucial events. We have analyzed the same set of data and established that in fact the heartbeats are characterized by the occurrence of crucial and Poisson events

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32

Rattray, Benjamin, and n/a. "The validation of physiological field testing in elite orienteers." University of Canberra. Sports Studies, 2002. http://erl.canberra.edu.au./public/adt-AUC20050629.113059.

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The complex physiology of orienteering performance is not well understood but recent advances in technology allow for more in-depth investigation. The purpose of this study was to develop and validate physiological field tests for elite orienteers in Australia. Seven male and three female elite orienteers volunteered to take part in the study. Subjects completed an incremental fixed-distance (803m) trial in Australian forest terrain, paced by a bicycle equipped with a speedometer. This was replicated in the laboratory using a 4.5% grade for treadmill running. Subjects also completed four (male

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33

López, Begines Santiago. "Unveiling novel components of the protein complex responsible for cGMP synthesis in retinal photoreceptors: role in cell physiology and disease." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/461890.

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In photoreceptor cells of the retina, light triggers a protein G-mediated enzymatic cascade that leads to hydrolysis of cGMP. The drop in cGMP levels causes the closure of cGMP-channel at the plasma membrane, decreasing the influx of cations, mainly Na+ and Ca2+, hyperpolarizing the cell. This hyperpolarization decreases the rate of neurotransmitter release at the synaptic terminal. Photoreceptor cells must recover the darkness equilibrium and adapt their light sensitivity to the wide range of light intensities present in the natural world. Genetic defects at both activation and termination ca

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34

GAMA, ARACHCHIGE NALIN SURANJITH. "PHYSICAL DORMANCY IN SEEDS, WITH SPECIAL REFERENCE TO GERANIACEAE: MORPHO-ANATOMY, DEVELOPMENT, PHYSIOLOGY, BIOMECHANICS AND CLASSIFICATION OF WATER-GAP COMPLEXES." UKnowledge, 2013. http://uknowledge.uky.edu/biology_etds/11.

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The primary aims of this dissertation were to (1) identify and characterize the water-gap complex in seeds of Geraniaceae, (2) investigate its role in physical dormancy (PY) break and (3) develop a new classification system for water-gap complexes in seeds of angiosperms. The winter annuals Geranium carolinianum and G. dissectum were selected as the main representative species for the study, and seeds of an additional 29 species from the Geraniaceae were used to compare the water-gap complex within the family. A new classification system for water-gap complexes in species with PY was developed

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35

McGuire, Vincent Michael. "Assembly and function of the PsB multiprotein complex during spore differentiation in Dictyostelium discoideum /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737858.

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36

Parrish, Austin R. "Effect of hybrid/complex N-glycosylation on cardiac voltage-gated ion channel expression." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1558106533403433.

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37

Bach, Eva C. "NMDA RECEPTORS IN THE DORSAL VAGAL COMPLEX OF NORMAL AND DIABETIC MICE." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/14.

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The dorsal vagal complex (DVC), containing the nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus nerve (DMV), plays a pivotal role in autonomic regulation. Afferent fibers from peripheral organs and higher brain centers synapse in the NTS, which integrates these synaptic connections as well as information from systemically circulating hormones and metabolites. The integrated information is relayed to the dorsal motor nucleus of the vagus nerve (DMV), which in turn, projects motor fibers to elicit parasympathetic control of digestive and other viscera. Physiological

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38

Varga, Adrienn Gabriella. "The Neural Basis of Head Direction and Spatial Context in the Insect Central Complex." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1487249074487484.

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39

Branvold, Devon Jack. "Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1407.

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AMP-activated protein kinase (AMPK), a heterotrimeric protein which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are increased in skeletal muscle tissue of hyperthyroid rats. Activity of AMPK is regulated by an upstream kinase (AMPKK). The LKB1-STRAD-MO25 complex is a major AMPKK in skeletal muscle. This experiment was designed to determine whether the increase in AMPK activity is accompanied by a thyroid hormone-ind

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40

Deng, Wei. "Sialylation and Cardiomyocyte Complex N -Glycosylation Protect Against Dilated Cardiomyopathy and Heart Failure." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6221.

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Dilated cardiomyopathy (DCM) is the third most common cause of heart failure, often associated with arrhythmias and sudden cardiac death if not controlled. Metabolic and/or environmental factors, such as alcohol abuse, obesity, diabetes and Chagas disease, alter glycoprotein glycosylation, can lead to DCM. Inherited genetic disease, such as the human congenital disorders of glycosylation (CDG), causes multi-system manifestations including DCM. Non-congenital changes in glycosylation are also occurred in humans with and in animal models of DCM and heart failure. However, mechanisms responsible

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Matott, Michael Patrick. "The Effects of Oxygen on the Electrophysiology of CO2/H+-Chemosensitive and -Insensitive Neurons of the Solitary Complex of the Rat." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4148.

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This study tested the hypothesis that decreasing the control O2 level from 95% to 40% (5% CO2 + 55% N2) maintains viability in caudal solitary complex (cSC) neurons in transverse slices (~300-400ꝳ) prepared from neonatal rat (P2-22) maintained at 32-34°C. The underlying rationale is to reduce exposure to redox and nitrosative stimuli generated during several hours of exposure to 95% O2 that produces a tissue O2 tension throughout the slice which is in excess of 203 kPa (2.0 atmospheres absolute,ATA) oxygen. Whole cell recordings of cSC neurons maintained in 40% O2 exhibited spontaneous firing

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42

Ferraz, Marcus Cima. "Um modelo para a dinâmica de abertura e fechamento dos estômatos de uma folha." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-20052014-161150/.

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Onde há luz suficiente ,os estômatos, pequenos poros localizados na superfície das folhas, com abertura regulável, tendem a abrir . Isto permite a absorção de C02 (e, portanto, a fotossíntese) , e a evaporação de água, que não pode, porém, ser excessiva. As plantas conseguem ajustar a sua abertura dos estômatos, otimizando a absorção de C02 e adequando-se, ao mesmo tempo, à disponibilidade de água no ambiente. Recentemente, inúmeras experiências mostraram que, ao contrário do que se supunha, a abertura de um estômato parece depender da interação deste com seus estômatos vizinhos. Sob estresse

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43

Theurer, Miles E. "Objective monitoring of cattle." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/32794.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Robert L. Larson<br>Bradley J. White<br>There are multiple modalities available to evaluate health or stress status of animals. The objective of my research was to evaluate different modalities including behavior, rectal and nasal temperature, and blood samples to determine the relationship with these outcomes of interest in bovine respiratory disease (BRD) events, environmental conditions, transportation, and Mannheimia haemolytica challenge model. The objective for the final project was to determine whether diagnostic

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44

Cheung, Amy. "The Role of Neurexins in Serotonin Signaling and Complex Behaviors." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1134.

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Extensive serotonin (5-HT) fiber innervation throughout the brain corroborates 5-HT’s modulatory role in numerous behaviors including social behavior, emotion regulation, and learning and memory. Abnormal brain 5-HT levels and function are implicated in Autism Spectrum Disorder (ASD) which often co-occurs with other neuropsychiatric conditions. While 5-HT therapeutics are used to treat ASD, variable improvements in symptomatology require further investigation of 5-HT-mediated pathology. Neurexins (Nrxns) are presynaptic cell adhesion molecules that maintain synapse function for proper neural c

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45

Negrin, Kimberly A. "Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/713.

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The worldwide prevalence of obesity and metabolic disease is increasing at an exponential rate and current projections provide no indication of relief. This growing burden of obesity-related metabolic disorders, including type 2 diabetes mellitus (T2DM), highlights the importance of identifying how lifestyle choices, genetics and physiology play a role in metabolic disease and place obese individuals at a greater risk for obesity-related complications including insulin resistance (IR). This increased risk of IR, which is characterized by a decreased response to insulin in peripheral tissues in

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46

Negrin, Kimberly A. "Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/713.

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The worldwide prevalence of obesity and metabolic disease is increasing at an exponential rate and current projections provide no indication of relief. This growing burden of obesity-related metabolic disorders, including type 2 diabetes mellitus (T2DM), highlights the importance of identifying how lifestyle choices, genetics and physiology play a role in metabolic disease and place obese individuals at a greater risk for obesity-related complications including insulin resistance (IR). This increased risk of IR, which is characterized by a decreased response to insulin in peripheral tissues in

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47

Glass, Jordan R. "Should I stay or should I go? Complex environments drive the developmental plasticity of flight capacity and flight-related tradeoffs." Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3535.

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Animals must balance multiple, fitness-related traits in environments that are complex and characterized by co-varying factors, such as co-variation in temperature and food availability. Thus, experiments manipulating multiple environmental factors provide valuable insight into the role of the environment in shaping not only important traits (e.g., dispersal capacity or reproduction), but also trait-trait interactions (e.g., trade-offs between traits). We employed a multi-factorial design to manipulate variation in temperature (constant 28°C vs. 28±5°C daily cycle) and food availability (unlim

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48

Abd, El Rahim Metwally Galal Yahya. "Molecular retention mechanisms of the G1 cyclin/Cdk complex in budding yeast." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/368230.

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Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream activator of Start is Cln3, a G1 cyclin that together with the cyclin-dependent kinase Cdc28 triggers a transcriptional wave that drives cell cycle entry. The Cln3 cyclin is a low abundant and very unstable protein whose levels respond very rapidly to nutritional changes. However, Cln3 expression is not sharply regulated through the cell cycle and it is already present in

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Mitchell, Cassie S. "Viewpoint aggregation via relational modeling and analysis." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28213.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Lee, Robert; Committee Member: Kemp, Melissa; Committee Member: Prinz, Astrid; Committee Member: Ting, Lena; Committee Member: Wiesenfeld, Kurt.

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Szucs, Kimberly A. "Capturing Three-Dimensional Clavicle Kinematics During Arm Elevation: Describing the Contribution of Clavicle Motion and Associated Scapulothoracic Muscle Activation to Total Shoulder Complex Motion." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275406915.

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