Academic literature on the topic 'Complex Spatiotemporal Interplay of Biomolecules'

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Journal articles on the topic "Complex Spatiotemporal Interplay of Biomolecules"

1

Nguyen, Trung Duc, Yuan-I. Chen, Limin H. Chen, and Hsin-Chih Yeh. "Recent Advances in Single-Molecule Tracking and Imaging Techniques." Annual Review of Analytical Chemistry 16, no. 1 (2023): 253–84. http://dx.doi.org/10.1146/annurev-anchem-091922-073057.

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Since the early 1990s, single-molecule detection in solution at room temperature has enabled direct observation of single biomolecules at work in real time and under physiological conditions, providing insights into complex biological systems that the traditional ensemble methods cannot offer. In particular, recent advances in single-molecule tracking techniques allow researchers to follow individual biomolecules in their native environments for a timescale of seconds to minutes, revealing not only the distinct pathways these biomolecules take for downstream signaling but also their roles in s
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Kataria, Meghna, and Hiroyuki Yamano. "Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis." Cells 8, no. 8 (2019): 814. http://dx.doi.org/10.3390/cells8080814.

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Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic phase and exit from it. A large E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) becomes active during latter stages of mitosis through G1 and marks hundreds of proteins for destruction. Recent studies
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HILLENBRAND, ULRICH, and J. LEO van HEMMEN. "Spatiotemporal adaptation through corticothalamic loops: A hypothesis." Visual Neuroscience 17, no. 1 (2000): 107–18. http://dx.doi.org/10.1017/s0952523800171111.

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The thalamus is the major gate to the cortex and its control over cortical responses is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic processing has been difficult to interpret. For an understanding of complex sensory processing, detailed concepts of the corticothalamic interplay need yet to be established. Drawing on various physiological and anatomical data, we elaborate the novel hypothesis that the visual cortex controls the spatiotemporal structure of cortical receptive fields via feedback to
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Miller, R. A., and B. E. Britigan. "Role of oxidants in microbial pathophysiology." Clinical Microbiology Reviews 10, no. 1 (1997): 1–18. http://dx.doi.org/10.1128/cmr.10.1.1.

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Reactive oxidant species (superoxide, hydrogen peroxide, hydroxyl radical, hypohalous acid, and nitric oxide) are involved in many of the complex interactions between the invading microorganism and its host. Regardless of the source of these compounds or whether they are produced under normal conditions or those of oxidative stress, these oxidants exhibit a broad range of toxic effects to biomolecules that are essential for cell survival. Production of these oxidants by microorganisms enables them to have a survival advantage in their environment. Host oxidant production, especially by phagocy
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Das, N. S., S. T. Dheen, E. A. Ling, B. H. Bay, and D. K. Srinivasan. "Therapeutic Prospects in Preeclampsia - A Mini-Review." Current Medicinal Chemistry 26, no. 25 (2019): 4786–98. http://dx.doi.org/10.2174/0929867326666190228115423.

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Background: Preeclapmsia (PE) is characterized by early onset symptoms such as elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures in the affected female. Currently, there are no therapeutic drugs available to treat this condition, but there are interventions to regulate the symptoms based on the gestational period of the fetus, although the largely favored option is delivery of the fetus and placenta. Objective: A search for biomolecules associated with PE was conducted so as to identify diagnostic markers and therapeutic leads. Results: The litera
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Zhang, Bing, Weijuan Huang, Sen Pei, et al. "Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study." PLOS Pathogens 18, no. 12 (2022): e1011046. http://dx.doi.org/10.1371/journal.ppat.1011046.

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Circulation of seasonal influenza is the product of complex interplay among multiple drivers, yet characterizing the underlying mechanism remains challenging. Leveraging the diverse seasonality of A(H3N2) virus and abundant climatic space across regions in China, we quantitatively investigated the relative importance of population susceptibility, climatic factors, and antigenic change on the dynamics of influenza A(H3N2) through an integrative modelling framework. Specifically, an absolute humidity driven multiscale transmission model was constructed for the 2013/2014, 2014/2015 and 2016/2017
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7

Abbasi, Omid, Nadine Steingräber, Nikos Chalas, Daniel S. Kluger, and Joachim Gross. "Spatiotemporal dynamics characterise spectral connectivity profiles of continuous speaking and listening." PLOS Biology 21, no. 7 (2023): e3002178. http://dx.doi.org/10.1371/journal.pbio.3002178.

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Speech production and perception are fundamental processes of human cognition that both rely on intricate processing mechanisms that are still poorly understood. Here, we study these processes by using magnetoencephalography (MEG) to comprehensively map connectivity of regional brain activity within the brain and to the speech envelope during continuous speaking and listening. Our results reveal not only a partly shared neural substrate for both processes but also a dissociation in space, delay, and frequency. Neural activity in motor and frontal areas is coupled to succeeding speech in delta
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Cowan, A. E., Y. Li, F. R. Morgan, et al. "Using the Virtual Cell Simulation Environment for Extracting Quantitative Parameters from Live Cell Fluorescence Imaging Data." Microscopy Today 17, no. 6 (2009): 36–39. http://dx.doi.org/10.1017/s1551929509991039.

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Rapid advances in fluorescence probe and imaging technologies now provide easily accessible tools for biologists to perform highly detailed analysis of molecular interactions in living cells. However it can be difficult to extract accurate parameters from these experiments because of the complex interplay of diffusion-reaction events with the morphology of the cell. As a result, only a small fraction of the available spatiotemporal information is utilized, and in many cases analysis remains at a qualitative level. The Virtual Cell (VCell, http://vcell.org) simulation environment is uniquely su
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Ruhl, C. J., R. E. Abercrombie, K. D. Smith, and I. Zaliapin. "Complex spatiotemporal evolution of the 2008 M w 4.9 Mogul earthquake swarm (Reno, Nevada): Interplay of fluid and faulting." Journal of Geophysical Research: Solid Earth 121, no. 11 (2016): 8196–216. http://dx.doi.org/10.1002/2016jb013399.

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Chen, Lijun, and Shangjing Jiang. "Spatiotemporal Polyrhythm Characteristics of Public Bicycle Mobility in Urban Chronotopes Context." ISPRS International Journal of Geo-Information 11, no. 1 (2021): 6. http://dx.doi.org/10.3390/ijgi11010006.

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Cycling rhythm performance is the result of a complex interplay between active travel demand and cycling network supply. Most studies focused on bicycle flow, but little attention has been paid to cycling rhythm changes for public bicycles. Full sample data of origin–destination enables an efficient description of network-wide cycling mobility efficiency in urban public bicycle systems. In this paper, we show how the spatiotemporal characteristics of cycling speed reveal the performance of cycling rhythms. The inference method of riding speed estimation is proposed with an unknown cycling path
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