Academic literature on the topic 'Complexe adapteur AP-1'

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Journal articles on the topic "Complexe adapteur AP-1"

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Yeung, Bonny G., Huan L. Phan, and Gregory S. Payne. "Adaptor Complex-independent Clathrin Function in Yeast." Molecular Biology of the Cell 10, no. 11 (1999): 3643–59. http://dx.doi.org/10.1091/mbc.10.11.3643.

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Clathrin-associated adaptor protein (AP) complexes are major structural components of clathrin-coated vesicles, functioning in clathrin coat assembly and cargo selection. We have carried out a systematic biochemical and genetic characterization of AP complexes inSaccharomyces cerevisiae. Using coimmunoprecipitation, the subunit composition of two complexes, AP-1 and AP-2R, has been defined. These results allow assignment of the 13 potential AP subunits encoded in the yeast genome to three AP complexes. As assessed by in vitro binding assays and coimmunoprecipitation, only AP-1 interacts with c
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Salazar, G., B. Craige, M. L. Styers, et al. "BLOC-1 Complex Deficiency Alters the Targeting of Adaptor Protein Complex-3 Cargoes." Molecular Biology of the Cell 17, no. 9 (2006): 4014–26. http://dx.doi.org/10.1091/mbc.e06-02-0103.

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Mutational analyses have revealed many genes that are required for proper biogenesis of lysosomes and lysosome-related organelles. The proteins encoded by these genes assemble into five distinct complexes (AP-3, BLOC-1-3, and HOPS) that either sort membrane proteins or interact with SNAREs. Several of these seemingly distinct complexes cause similar phenotypic defects when they are rendered defective by mutation, but the underlying cellular mechanism is not understood. Here, we show that the BLOC-1 complex resides on microvesicles that also contain AP-3 subunits and membrane proteins that are
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Fölsch, Heike, Marc Pypaert, Sandra Maday, Laurence Pelletier, and Ira Mellman. "The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains." Journal of Cell Biology 163, no. 2 (2003): 351–62. http://dx.doi.org/10.1083/jcb.200309020.

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Most epithelial cells contain two AP-1 clathrin adaptor complexes. AP-1A is ubiquitously expressed and involved in transport between the TGN and endosomes. AP-1B is expressed only in epithelia and mediates the polarized targeting of membrane proteins to the basolateral surface. Both AP-1 complexes are heterotetramers and differ only in their 50-kD μ1A or μ1B subunits. Here, we show that AP-1A and AP-1B, together with their respective cargoes, define physically and functionally distinct membrane domains in the perinuclear region. Expression of AP-1B (but not AP-1A) enhanced the recruitment of a
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Kim, Myung-Hee, and Louis B. Hersh. "The Vesicular Acetylcholine Transporter Interacts with Clathrin-associated Adaptor Complexes AP-1 and AP-2." Journal of Biological Chemistry 279, no. 13 (2004): 12580–87. http://dx.doi.org/10.1074/jbc.m310681200.

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Sorkina, T., A. Bild, F. Tebar, and A. Sorkin. "Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors." Journal of Cell Science 112, no. 3 (1999): 317–27. http://dx.doi.org/10.1242/jcs.112.3.317.

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Activation of the epidermal growth factor receptor (EGFR) by EGF results in binding of clathrin adaptor protein complex AP-2 to the receptor cytoplasmic tail. The transient interaction with AP-2 is thought to be responsible for the selective recruitment of the EGFR into coated pits during endocytosis. In this study we found that EGF-induced EGFR/AP-2 association, measured by co-immunoprecipitation, persists after receptor internalization. Double-label immunofluorescence of EGF-treated A-431 and COS-1 cells revealed the presence of AP-2, clathrin and eps15, another component of the plasma membr
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Fölsch, Heike, Marc Pypaert, Peter Schu, and Ira Mellman. "Distribution and Function of Ap-1 Clathrin Adaptor Complexes in Polarized Epithelial Cells." Journal of Cell Biology 152, no. 3 (2001): 595–606. http://dx.doi.org/10.1083/jcb.152.3.595.

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Expression of the epithelial cell–specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney cells. AP-1B is distinguished from the ubiquitously expressed AP-1A by exchange of its single 50-kD μ subunit, μ1A, being replaced by the closely related μ1B. Here we show that this substitution is sufficient to couple basolateral plasma membrane proteins, such as a low-density lipoprotein receptor (LDLR), to the AP-1B complex and to clathrin. The interaction between LDLR and AP-1B is likely to occur
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BAROIS, Nicolas, and Oddmund BAKKE. "The adaptor protein AP-4 as a component of the clathrin coat machinery: a morphological study." Biochemical Journal 385, no. 2 (2005): 503–10. http://dx.doi.org/10.1042/bj20041010.

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The four members of the AP (adaptor protein) family are heterotetrameric cytosolic complexes that are involved in the intracellular trafficking of cargo proteins between different organelles. They interact with motifs present in the cytoplasmic tails of their specific cargo proteins at different intracellular locations. While AP-1, AP-2 and AP-3 have been investigated extensively, very few studies have focused on the fourth member, AP-4. In the present study, we report on the intracellular localization of AP-4 in the MDCK (Madin–Darby canine kidney) and MelJuSo cell lines after immunogold labe
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Nie, Z. "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3." Journal of Cell Science 118, no. 15 (2005): 3555–66. http://dx.doi.org/10.1242/jcs.02486.

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Barone, Maria Elena, Alexis Lim, Madison Woody, et al. "Adaptor Protein Complexes in HIV-1 Pathogenesis: Mechanisms and Therapeutic Potential." Viruses 17, no. 5 (2025): 715. https://doi.org/10.3390/v17050715.

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Adaptor protein (AP) complexes are critical components of the cellular membrane transport machinery. They mediate cargo selection during endocytosis and intracellular vesicular trafficking. Five AP complexes have been characterized (AP1-5), and together their roles extend to diverse cellular processes including the homeostasis of membranous organelles, membrane protein turnover, and immune responses. Human Immunodeficiency Virus type 1 (HIV-1) and other lentiviruses co-opt these complexes to support immune evasion and the assembly of maximally infectious particles. HIV-1 Nef interacts with AP1
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Lefkir, Yaya, Benoît de Chassey, Annick Dubois, et al. "The AP-1 Clathrin-adaptor Is Required for Lysosomal Enzymes Sorting and Biogenesis of the Contractile Vacuole Complex in Dictyostelium Cells." Molecular Biology of the Cell 14, no. 5 (2003): 1835–51. http://dx.doi.org/10.1091/mbc.e02-10-0627.

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Adaptor protein complexes (AP) are major components of the cytoplasmic coat found on clathrin-coated vesicles. Here, we report the molecular and functional characterization of Dictyostelium clathrin-associated AP-1 complex, which in mammalian cells, participates mainly in budding of clathrin-coated vesicles from the trans-Golgi network (TGN). The γ-adaptin AP-1 subunit was cloned and shown to belong to a Golgi-localized 300-kDa protein complex. Time-lapse analysis of cells expressing γ-adaptin tagged with the green-fluorescent protein demonstrates the dynamics of AP-1–coated structures leaving
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Dissertations / Theses on the topic "Complexe adapteur AP-1"

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Ferrié, Martin. "Étude de la maturation protéolytique et du trafic intracellulaire de la protéine de capside ORF2 du virus de l'hépatite E (HEV)." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS067.

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L'infection par le virus de l'Hépatite E (HEV) est un problème majeur de santé publique qui toucherait 100 millions de personnes et tuerait 100 000 personnes chaque année dans le monde. Le HEV est la première cause d'hépatite aigüe dans le monde. En France, la séroprévalence s'élève à 22,4%. Ce virus se transmet par voie féco-orale ou par la consommation de viande contaminée mal cuite. Au cours de ma thèse, je me suis intéressé plus particulièrement à la protéine de capside ORF2, qui est l'unité structurale des particules virales et un acteur central du cycle infectieux du HEV. La protéine ORF
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Dugast, Marc. "Mécanismes de tri impliqués dans le trafic intracellulaire des molécules du CMH II et dans les effets de Nef du VIH-1 sur les CMH et CD4." Paris 7, 2005. http://www.theses.fr/2005PA077016.

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Shafaq-Zadah, Massiullah. "Rôle du complexe adaptateur pour la clathrine AP-1 dans le maintien de la polarité épithéliale chez Caenorhabditis elegans." Phd thesis, Université Rennes 1, 2012. http://tel.archives-ouvertes.fr/tel-00683716.

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La polarité épithéliale est un processus essentiel au cours du développement d'un organisme. Ici, nous nous focalisons sur le tissu épithélial intestinal et épidermal de C. elegans pour comprendre comment la cellule maintient sa polarité en définissant un pôle apical et un pôle basolatéral. Afin d'assurer la mise en place et le maintien de cette polarité, des protéines appelées déterminants de polarité interviennent. Parmi ces déterminants, le module PAR-3/PAR-6/aPKC et CDC-42 sont des acteurs majeurs pour spécifier la polarité apicale. Nous avons montré que le complexe adaptateur pour la clat
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Foote, Christopher. "The role of the AP-1 adaptor complex in trafficking between the trans-Golgi Network and endosomal system." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4172.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (November 7, 2006) Vita. Includes bibliographical references.
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Duvoix, Annelyse. "Régulation transcriptionnelle de la glutathion S-transférase P1-1 via AP-1 et NF-kB dans les cellules leucémiques humaines@ : effet inhibiteur des agents chimiopréventifs d'origine naturelle." Nancy 1, 2003. http://docnum.univ-lorraine.fr/public/SCD_T_2003_0248_DUVOIX.pdf.

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La glutathion S-Transférase Pl-1 (GSTP1-1), impliquée dans la conjugaison de composés électrophiles au glutathion, la cancérogénèse et le développement de résistances aux anticancéreux, reste peu étudiée dans 16' cas des leucémies humaines en ce qui concerne l'expression du gène ainsi que des voies de transduction du signal impliquées. Dans une étude précédente, notre équipe a montré l'importance du site AP-l en tant que régulateur du promoteur minimal de la GSTP1-l. Pour ce travail, nous montrons dans un premier temps que des inducteurs typiques d'AP-l comme l'ester de phorbol TPA ou les mét1
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Rahmani, Mohamed. "Etude du complexe AP-1 dans les hépatocytes de rat traités par les facteurs de croissance et les promoteurs tumoraux : activation, composition et coopération avec NF-kB." Paris 7, 1999. http://www.theses.fr/1999PA077211.

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Le complexe AP-1 est l'une des plaques tournantes majeures de la signalisation intracellulaire. C'est un facteur transcriptionnel homodimérique, formé de deux protéines Jun (c-Jun, junB, JunD) ou hétérodimérique, formé d'une protéine Jun et d'une protéine Fos (c-Fos, FosB, Frai , Fra2). Cette thèse a été focalisée sur le fonctionnement du complexe AP-1 dans les hépatocytes et sur ses possibles interactions avec NF-KB. Ces travaux ont abouti à la mise en évidence d'une différence qualitative de la composition du complexe AP-1 entre hépatocytes normaux et transformés. A l'état basal, le complexe
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Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula
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Riel, Constanze. "σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1". Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-ABD8-5.

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Mishra, Ratnakar. "Mechanisms of synaptic plasticity mediated by Clathrin Adaptor-protein complexes 1 and 2 in mice." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0003-C12E-0.

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Riel, Constanze [Verfasser]. "σ1-adaptin [sigma-1-adaptin] : the small subunit of the clathrin adaptor complex AP-1 [[Elektronische Ressource]] / vorgelegt von Constanze Riel". 2005. http://d-nb.info/976246805/34.

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