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1

Soules, Régis. "Proprietes cooperatives de complexes polymetalliques des ligands squarate et thiosquarate." Toulouse 3, 1987. http://www.theses.fr/1987TOU30178.

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Etude de l'emploi d'un coordinat assembleur qui puisse par coordination avec le centre metallique utilise (metaux de transition du groupe viii) aboutir a un agencement a une dimension des motifs moleculaires par empilement d'entites monomeres ou par formation de chaines. Par utilisation du coordinat squarate sous ses formes oxygenees et soufrees, obtention d'un certain nombre de complexes de pt, pd, ni et cu repondant aux criteres fixes. Etude des structures de ces composes, de leurs proprietes physiques et de la relation structure-propriete. La nature du coordinat comme le caractere specifiqu
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2

Mackay, Craig Donald. "Beta-catenin complexes in colorectal cancer." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/e5555e02-d76e-4729-8737-88a11cf3e563.

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Genetic mutations that initiate and drive the progression of colorectal cancer cause defects in key signalling pathways that affect cell function. The Wnt signalling pathway is a key pathway that is disrupted in colorectal cancer and β-catenin is the key mediator of Wnt signalling. β-catenin is a multifunctional protein with roles in Wnt signalling and cell adhesion. I aimed to understand the relationship between the main interactions and functions of β-catenin. Specifically, I investigated how a stabilising mutation in β-catenin, decreases in APC, E-cadherin or PTEN altered the interactions o
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3

Marques, Elizabete. "Proprietes complexantes de nouveaux recepteurs moleculaires : catenands et calixarenes fonctionnalises." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13105.

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Proprietes complexantes des coordinats : cat-30, de son motif constitutif m-30, de dimethyl-2,9 phenanthroline-1. 10 et de di(p-anasyl-)2,9 phenantroline-1. 10, vis a vis de cu**(+), ag, li, zu, cd. On etudie egalement les derives de calixarenes comportant des groupes ester ou cetone sur les o phenoliques-meres
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4

Campbell, Christopher James. "Synthesis of topologically complex molecules." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/17071.

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The study of topologically complex molecules is necessary to better understand the knotted architectures that abound within Nature and are vital in the functioning of DNA and proteins. Metal based template strategies have played a key role in the successful synthesis of a number of interwoven structures constructed from small molecule building blocks, however novel methodology is crucial for the expansion of this fascinating field of chemistry. The strategy of linking the ends of a cyclic helicate has been developed within the Leigh group and applied with great success to the synthesis of the
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5

Wilding, Jonathan Charles. "Functional significance of the E-cadherin catenin complex in cervical cancer." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268023.

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6

Carollo, Pietro Salvatore. "The LINC complexe is a mechanotransducer that regulates catenin signaling during epithelial-mesenchymal transitions." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/CAROLLO_PietroSalvatore_va1.pdf.

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Dans les organismes multicellulaires, les cellules génèrent et subissent des forces mécaniques. En conséquence, ces forces peuvent réguler le comportement cellulaire ainsi que l'organisation des tissus grâce à un processus appelé «mécanotransduction», par lequel les cellules convertissent les stimuli mécaniques en signaux biochimiques. Dans les cellules animales, le noyau est couplé mécaniquement par le cytosquelette aux complexes d’adhésion cellulaire, de sorte que des signaux mécaniques extracellulaires puissent affecter la position et la forme du noyau. Un tel couplage mécanique est assuré
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7

Woodfield, Richard John. "Investigation of the association of P13K with the cadherin-catenin adhesion complex." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368435.

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8

Badreddine, Jawad. "Modélisation du grenaillage ultrason pour des pièces à géométrie complexe." Thesis, Troyes, 2014. http://www.theses.fr/2014TROY0015/document.

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Le grenaillage ultrason est un procédé mécanique de traitement de surfaces. Il consiste à projeter des billes à la surface de pièces métalliques, à l’aide d’un système acoustique vibrant ultrasonore. Lors du traitement, les billes sont contenues dans une enceinte spécialement conçue pour la pièce à traiter, et adoptent un comportement similaire à celui d’un gaz granulaire vibré. Le grenaillage ultrason sert à introduire des contraintes résiduelles de compression dans le matériau traité. Ces contraintes de compression sont bénéfiques pour la tenue en fatigue de la pièce et sa résistance à la co
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9

Weiss, Jean. "Synthese de (2) et (3)-catenands, coordinats a anneaux entrelaces." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13110.

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10

Jawhari, Aida Urfan Fuad. "Control of gastrointestinal epithelial differentiation and migratory behaviour, by the cadherin-catenin complex." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312709.

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11

Maria, Magalhães Melo Aline. "Fungos micorrízicos arbusculares (Glomeromycota) em fragmentos de Mata Atlântica no centro de Endemismo Pernambuco." Universidade Federal de Pernambuco, 2004. https://repositorio.ufpe.br/handle/123456789/681.

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Made available in DSpace on 2014-06-12T15:04:40Z (GMT). No. of bitstreams: 2 arquivo4504_1.pdf: 922588 bytes, checksum: 02b187518cef5c3ab20896f9b310a721 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2004<br>Os fungos micorrízicos arbusculares (FMA), biotróficos obrigatórios, formam associação simbiótica com a maioria das plantas, contribuem para a composição florística e a estabilidade dos ecossistemas naturais e são importantes na agregação do solo e na ciclagem de nutrientes. Os FMA produzem uma glicoproteína denominada glomalina relac
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12

Maher, Louise Sameen. "Helicobacter pylori and the E-cadherin-catenin complex in the pathogenesis of gastric cancer." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248047.

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13

Tutter, Antonin V. "Chromatin binding and transcription activation by the LEF-1:[beta]-Catenin complex in vitro /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3022218.

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14

Soncin, Francesca. "The role of the E-cadherin/B-catenin complex in mouse embryonic stem cells." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527425.

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15

Edel, André. "Photochimie d'un complexe du cuivre (i) : etude dynamique et structurale par rmn de catenands et catenates." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13016.

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L'etude des proprietes photo-physiques et -chimiques du complexe cu(diphenylphenan)::(2)**(+) conduit au premier exemple d'un complexe de cu (i) realisant la photoreduction de l'eau sous irradiation en lumiere visible. Etude rmn de cu (cat-30)**(+) et cu (cat-27)**(+) montrant qu'ils presentent des proprietes topographiques identiques
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16

Gayrard, Charlène. "Mécanotransduction au complexe E-cadhérine/β-caténine lors de la transition épithelio-mésenchymateuse". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC269/document.

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Dans les organismes multicellulaires, les cellules génèrent et subissent des forces mécaniques qui se propagent aux cellules voisines. Ces forces peuvent déterminer la forme des tissus et organes, et aussi être converties en signaux biochimiques. Dans un épithélium, les cellules forment un tissu en adhérant directement les unes aux autres grâce à des complexes d’adhérence, tels que les Jonctions Adhérentes. Ces Jonctions Adhérentes sont composées de protéines transmembranaires les E-cadhérines, dont la partie cytoplasmique est sous tension générée par le cytosquelette d’actomyosine par un lien
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17

Gusev, Ekaterina. "Regulation of the Wnt pathway: analysis of ß-catenin phosphorylation by the endogenous Axin-based complexes." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107698.

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Abstract:Signal transduction is an essential mechanism through which information generated by environmental cues can modulate cellular functions and genetic programs. The so-called canonical Wnt/β-catenin pathway has long been known for its critical role in regulation of cell proliferation and differentiation. The key mechanism in this pathway is phosphorylation of β-catenin, but the precise mechanism of its regulation remains poorly understood. This study aims, for the first time, to directly investigate the activity of the core complex responsible for phosphorylation of β-catenin. This compl
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18

Mills, Fergil. "The role of beta-catenin and the cadherin adhesion complex in synaptic plasticity, learning and addiction." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52342.

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A fundamental property of synapses is their ability to change in response to activity, termed ‘synaptic plasticity’. Synaptic activity can cause long-lasting increases in the strength of synapses (long-term potentiation, or ‘LTP’), as well as decreases in synapse strength (long-term depression or ‘LTD’), both of which are believed to be important for learning and memory. The synaptic adhesion molecules ‘cadherins’ and their intracellular binding partner β-catenin have been identified as key mediators of plasticity at synapses. The cadherin adhesion complex is important for maintaining the stre
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19

GUIMARÃES, Francisco José Pimentel. "Avaliação da estrutura de um fragmento florestal no município de Catende, PE." Universidade Federal Rural de Pernambuco, 2005. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5475.

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Submitted by (lucia.rodrigues@ufrpe.br) on 2016-08-24T14:46:37Z No. of bitstreams: 1 Francisco Jose Pimentel Guimaraes.pdf: 507209 bytes, checksum: 09b8f156f4db1c6fbc9926452906ca72 (MD5)<br>Made available in DSpace on 2016-08-24T14:46:37Z (GMT). No. of bitstreams: 1 Francisco Jose Pimentel Guimaraes.pdf: 507209 bytes, checksum: 09b8f156f4db1c6fbc9926452906ca72 (MD5) Previous issue date: 2005-08-31<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>The main goal of this study was to
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20

Pachón, Andrés Felipe Aristizábal. "Alterações Genéticas e Epigenéticas dos Genes do Complexo de Destruição de β-Catenina e Perfil Transcricional dos Componentes da Via de Sinalização Wnt no Câncer de Mama." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-28072015-100134/.

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O câncer de mama é a neoplasia responsável pelo maior número de mortes em mulheres no Brasil, portanto, é importante encontrar novos marcadores específicos e de diagnóstico precoce, utilizando procedimentos simples e rápidos. A via de sinalização Wnt regula importantes funções celulares como proliferação, sobrevida e adesão. Esta via está associada com os processos de iniciação e progressão em muitos tipos tumorais, como câncer de cólon familiar, melanoma e pulmão; sendo que mutações em &beta;-Catenina (CTNNb1) explicam só 30% dos casos de sinalização aberrante encontrada no câncer de mama, in
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21

Yoshihara, Ken. "Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes." Kyoto University, 2011. http://hdl.handle.net/2433/147333.

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22

Mialhe, Agnès. "Expression du complexe d'adhérence E-cadhérine/caténines dans les cellules tumorales vésicales." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10100.

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Dans les cancers epitheliaux ou carcinomes, la perte d'adherence intercellulaire est probablement une des premieres etapes des mecanismes d'invasion et de formation des metastases. De recentes avancees demontrent que la e-cadherine, molecule d'adherence intercellulaire specifique des cellules epitheliales, mais egalement les catenines, groupe de proteines cytoplasmiques interagissant avec la cadherine, sont particulierement alterees dans les carcinomes invasifs. Ce travail de these a ete consacre a l'etude des anomalies d'expression du complexe e-cadherine-catenines dans le carcinome vesical,
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23

Adhikari, Shishir Raj. "STATISTICAL PHYSICS OF CELL ADHESION COMPLEXES AND MACHINE LEARNING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1562167640484477.

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24

Campos, Maria Luisa Morais Sarmento de. "ICAT: a novel Ptf 1A/P48 partner that modulates acinar expression." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7233.

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Ptf1a/p48 is a pancreas specific bHLH transcription factor that is required at early stages of embryonic development for pancreas formation and, during adulthood, for the proper exocrine pancreatic function. P48 also exerts an antiproliferative effect, which may exert a tumor suppressor activity. In this study, based on a yeast two-hybrid approach, we have identified new p48 partners that modulate the activity of p48. Among the newly identified putative interactors we found p/CAF, which is a coactivator that potentiates its transcriptional activity, and ICAT, an inhibitor of the &#946;-catenin
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25

Tang, Yi. "The role of transforming growth factor beta-1 in bone remodeling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/tang.pdf.

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26

Silva, Neto Brasil. "A transição epitélio-mesenquimal em tumores uroteliais de bexiga : identificação e significado prognóstico da expressão de proteínas do complexo caderina-catenina em microarranjos de tecidos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/19091.

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27

Lefèvre, Lucile. "Rôles de la voie de signalisation Wnt/β-caténine et d’un nouveau gène cible, AFF3, dans les carcinomes de la corticosurrénale". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T010.

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Les carcinomes de la corticosurrénale (CC) sont des tumeurs malignes rares dont le pronostic est globalement sombre et les thérapeutiques encore limitées, la chirurgie étant le seul traitement efficace. Il est donc important de comprendre les mécanismes impliqués dans le développement et l'agressivité des CC. L’activation constitutive de la voie de signalisation Wnt/b-caténine est fréquente dans les CC (40%) et est associée à un caractère agressif. L’objectif de mon projet de thèse était d’étudier l’implication de la voie Wnt/β-caténine dans la tumorigenèse corticosurrénalienne. La lignée cell
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Batisse, Lignier Marie. "Progression tumorale dans un modèle murin de carcinogénèse surrénalienne ciblée induite par antigène T de SV 40 : Recherche de cibles thérapeutiques pour le corticosurrénalome." Thesis, Clermont-Ferrand 1, 2016. http://www.theses.fr/2016CLF1MM07.

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Les corticosurrénalomes (CS), bien que rares, sont des tumeurs malignes du cortex surrénalien très agressives. Environ 30% des patients atteints de cancer surrénalien présentent des métastases au diagnostic et leur survie à 5 ans est inférieure à 20%. Les mécanismes à l’origine de la progression cancéreuse ne sont pas complètement élucidés. Leur compréhension est pourtant un préalable à la mise au point de traitements adaptés. Les mutations du gène P53 font parties des altérations génétiques les plus fréquentes dans les CS. Dans ce contexte, il est légitime d'étudier l'effet de l'inactivation
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29

Danezan, Meredith. "Du texte d'auteur aux textes des chaînes. Édition et traduction des chaînes aux Proverbes (1-3 ; 8, 22-36 ; 30, 15-33 et 31, 10-31)." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUL147.

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Le présent ouvrage livre la première édition et la première traduction de l’ensemble des chaînes aux Proverbes recensées pour les Chapitres 1 à 3 ; 8, 22-36 ; 30, 15-33 et 31, 10-31 des Proverbes. Les résultats de cette recherche permettent de considérer sous un jour nouveau la mouvance observée entre les différentes traditions caténaires. L’apport d’un manuscrit jusqu’ici négligé, le Bodleianus Barocci 195, permet de démêler l’écheveau de textes amalgamés, non délimités, souvent anonymes et parfois fautivement attribués par les caténistes ou les critiques. Il permet de retrouver un état de te
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30

Yang, Kefei [Verfasser], Sigrid [Akademischer Betreuer] Hoyer-Fender, Wolfgang [Akademischer Betreuer] Engel та ін. "Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex / Kefei Yang. Gutachter: Sigrid Hoyer-Fender ; Wolfgang Engel ; Michael Kessel ; Ernst A. Wimmer ; Detlef Doenecke ; Martin Göpfert. Betreuer: Sigrid Hoyer-Fender". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1069235199/34.

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Lou, Pei-Jen, and 婁培人. "Studies on the Cadherin/Catenin Complex and Nasopharyngeal Carcinoma." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/87185063997770757529.

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博士<br>國立臺灣大學<br>解剖學研究所<br>88<br>Cadherins are Ca2+-dependent transmembrane glycoproteins responsible for establishing physical cell-cell associations and are important in tissue morphogenesis, cell polarity, and tumor invasiveness. In cancer cells, the cadherin-mediated cell adhesion system is known to act as an “invasion suppressor system”. The cytoplasmic portion of the cadherins is associated with catenins, which, in turn, associate with the actin-based cytoskeleton. This linkage between the cadherin/catenin complex and actin filaments is required for the functional integrity of the cadheri
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32

高德依. "A co-activator of Lef-1-B-catenin transcriptional complex." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/89743975103882561710.

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Hsu, Ho-Chen, та 許賀竣. "Musashi-1 Regulates β-Catenin Destruction Complex in Colorectal Cancer Cells and Organoids Self-Organization". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5bwn57.

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34

Dasgupta, Ramanuj. "Multiple roles for activated beta-catenin/Lef1/Tcf transcription complexes during hair organogenesis and hair cycling /." 2002. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3039024.

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35

Mahomed, Farzana. "Expression of the E-cadherin/B-catenin complex in oral squamous cell carcinoma and its correlation with histomorphology and metastasis." Thesis, 2006. http://hdl.handle.net/10539/1432.

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Student No. 9404705H MDent Research Report School of Oral Sciences<br>Expression of the E-cadherin/β-catenin complex in oral squamous cell carcinoma and its correlation with histomorphology and metastasis. The immunohistochemical expression of E-cadherin and β-catenin was examined in 30 primary oral squamous cell carcinomas in patients with (n=19) and without (n=11) nodal metastasis, as confirmed on histopathological examination of the resected regional lymph nodes. The corresponding primary and nodal metastases tissue samples were available for 17 patients. The 30 primary carcinomas w
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36

Tuskey, Christina. "The Caenorhabditis elegans zonula occludens ortholog cooperates with the cadherin-catenin complex to regulate epidermal morphogenesis /." 2007. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Chen, Sz-chi, and 陳思齊. "The Expression of Cadherin-Catenin Complex and nm23 Protein in Nasopharyngeal Carcinoma Tissues: the Correlation with NPC." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/41123001097511411076.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>87<br>The altered expressions of certain cellular proteins play important roles in the progression of many carcinomas. In the tissues of epithelial origin, the E-cadherin-catenin-mediated adhesion is an important factor for maintaining its integrity. Any defect in the related components would result in the unfavorable outcome, such as migration of the cells to distantly unrelated organs. In this study, the expressions of the molecules of cadherin-catenin complex (E-cadherin, alpha-, beta-, gamma-catenins and APC) were evaluated in nasopharyngeal carcinoma tissues. T
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Kubesh, Mary Margaret. "Analysis of the over-expression and regulation of the cadherin-catenin complex during border cell migration in the Drosophila ovary." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450433&T=F.

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Grogan, Kathleen Elizabeth. "Exploring the Impacts of Major Histocompatibility Complex Variation on Fitness in the Ring-tailed Lemur (Lemur catta): Parasite Resistance, Survival, Mate Choice and Olfactory Ornamentation, and Reproduction." Diss., 2014. http://hdl.handle.net/10161/9405.

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<p>The threats of human encroachment and climate change are increasing and understanding the interplay between genetic diversity, fitness, and ecological variation has become critical for predicting adaptive responses and species extinction risk. Decreasing genetic diversity, owing to population decline or inbreeding, can be detrimental at the level of the individual, population, or species. One of the major challenges for evolutionary and conservation biologists is identifying the specific genetic components that influence inter-individual variation in fitness remains. As a direct link bet
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40

Yang, Kefei. "Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex". Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5FA2-A.

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