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Journal articles on the topic 'Complexe immun circulant'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Nicaise-Roland, Pascale. "Complexes immuns circulants." EMC - Biologie Médicale 1, no. 1 (2006): 1–2. http://dx.doi.org/10.1016/s2211-9698(06)76223-9.

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2

Yang, Hui, Jing Guan, Pei Ma, et al. "Beneficial Effects of Qingzixiaoban Granule on Henoch–Schönlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation." Evidence-Based Complementary and Alternative Medicine 2019 (October 16, 2019): 1–14. http://dx.doi.org/10.1155/2019/3050248.

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Background. Henoch–Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in Henoch–Schönlein purpura (HSP). However, there is no absolute consensus for the best management of severe HSPN till now. Qingzixiaoban Granule (QZXB GR), a traditional Chinese medicine formula, has been applied to treat HSP in clinical in China. However, the therapeutic effects and potential mechanism of QZXB GR on HSPN is still unknown. Methods. A Gliadin plus Indian Ink-induced HSPN mice model was established. Renal histopathologic changes and the subcutaneous hemorrhage on left legs we

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3

Mihailov, CI, A. Lamour, B. Bendaoud, et al. "Signification diagnostique au cours des connectivities de l'isotype des complexes immuns circulants." La Revue de Médecine Interne 13, no. 7 (1992): S326. http://dx.doi.org/10.1016/s0248-8663(05)80913-0.

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4

Ghiran, Ionita, Aleksandra M. Glodek, Gregory Weaver, Lloyd B. Klickstein, and Anne Nicholson-Weller. "Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1." Blood 112, no. 8 (2008): 3465–73. http://dx.doi.org/10.1182/blood-2008-04-151845.

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Abstract The primary identified function of complement receptor 1 (CR1/CD35) on primate erythrocytes is to bind complement-tagged inflammatory particles including microbes and immune complexes. When erythrocytes circulate through liver and spleen, sinusoidal phagocytes remove CR1-adherent particles and erythrocytes return to the circulation. This process of immune adherence clearance is important for host defense and prevention of autoimmunity. CR1 was previously described as clustered in the human erythrocyte membrane, which was thought to be necessary for binding complement-opsonized particl

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Candolfi, E., B. Molet, and T. Kien. "L'antigénémie et les complexes immuns circulants spécifiques dans l'échinococcose hydatique humaine. A propos de 16 cas." Médecine et Maladies Infectieuses 16, no. 5 (1986): 369–73. http://dx.doi.org/10.1016/s0399-077x(86)80038-5.

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6

Bentley-Hibbert, Stuart I., Xin Quan, Thomas Newman, Kris Huygen, and Henry P. Godfrey. "Pathophysiology of Antigen 85 in Patients with Active Tuberculosis: Antigen 85 Circulates as Complexes with Fibronectin and Immunoglobulin G." Infection and Immunity 67, no. 2 (1999): 581–88. http://dx.doi.org/10.1128/iai.67.2.581-588.1999.

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ABSTRACT Antigen 85 (Ag85) complex proteins are major secretory products ofMycobacterium tuberculosis and induce strong cellular and humoral immune responses in infected experimental animals and human beings. We have previously shown that nanogram doses of these 30- to 32-kDa fibronectin-binding proteins inhibit local expression of delayed hypersensitivity by a T-cell fibronectin-dependent mechanism. Circulating levels of Ag85 might be expected to be elevated in patients with active tuberculosis and possibly to play a role in systemic anergy in these patients. To test this hypothesis, Ag85 was

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7

Halat, Monika, Magdalena Klimek-Chodacka, Jagoda Orleanska, Malgorzata Baranska, and Rafal Baranski. "Electronic Circular Dichroism of the Cas9 Protein and gRNA:Cas9 Ribonucleoprotein Complex." International Journal of Molecular Sciences 22, no. 6 (2021): 2937. http://dx.doi.org/10.3390/ijms22062937.

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The Streptococcus pyogenes Cas9 protein (SpCas9), a component of CRISPR-based immune system in microbes, has become commonly utilized for genome editing. This nuclease forms a ribonucleoprotein (RNP) complex with guide RNA (gRNA) which induces Cas9 structural changes and triggers its cleavage activity. Here, electronic circular dichroism (ECD) spectroscopy was used to confirm the RNP formation and to determine its individual components. The ECD spectra had characteristic features differentiating Cas9 and gRNA, the former showed a negative/positive profile with maxima located at 221, 209 and 19

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8

Tsai, Chang-Youh, Chieh-Yu Shen, Chih-Wei Liu, et al. "Aberrant Non-Coding RNA Expression in Patients with Systemic Lupus Erythematosus: Consequences for Immune Dysfunctions and Tissue Damage." Biomolecules 10, no. 12 (2020): 1641. http://dx.doi.org/10.3390/biom10121641.

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Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with heterogeneous clinical manifestations. A diverse innate and adaptive immune dysregulation is involved in the immunopathogenesis of SLE. The dysregulation of immune-related cells may derive from the intricate interactions among genetic, epigenetic, environmental, and immunological factors. Of these contributing factors, non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs), and long non-coding RNAs (lncRNAs) play critical roles in the post-transcriptional mRNA expression of cytokines, chemokines, and growth

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9

Nourmohammad, Armita, Jakub Otwinowski, Marta Łuksza, Thierry Mora, and Aleksandra M. Walczak. "Fierce Selection and Interference in B-Cell Repertoire Response to Chronic HIV-1." Molecular Biology and Evolution 36, no. 10 (2019): 2184–94. http://dx.doi.org/10.1093/molbev/msz143.

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Abstract During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host’s adaptive immune system. While it is clear that HIV exerts strong selection on the adaptive immune system, the characteristics of the somatic evolution that shape the immune response are still unknown. Traditional population genetics methods fail to distinguish chronic immune response from healthy repertoire evolution. Here, we infer the evolutionary modes of B-cell repertoires and identify complex dynamics with a constant production of better B-cell receptor (BCR) mutants that compete, maintain

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10

Serebryanaya, N. B., P. P. Yakutseni, and N. N. Klimko. "Platelets in invasive aspergillosis: role in pathogenesis and immune defense." Journal Infectology 11, no. 2 (2019): 26–34. http://dx.doi.org/10.22625/2072-6732-2019-11-2-26-34.

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Invasive aspergillosis (IA) is a serious disease, with mortality rate up to 80%. A. fumigatus is an angiovasive pathogen, fragments of its hyphae can detach and circulate in the bloodstream. Platelets are activated by surface structures, metabolites and soluble fungal complexes, resulting in adhesion to conidia and fungal hyphae. The melanin and hydrophobin contained in the conidia, as well as the galactosaminogalactan contained in the hyphae and the glyphotoxin secreted by the hyphae, suppress phagocytic cells, but activate the platelets. Activated platelets show direct antifungal activity by

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11

Kujala, Pekka, Anne Ikäheimonen, Neda Ehsani, Helena Vihinen, Petri Auvinen, and Leevi Kääriäinen. "Biogenesis of the Semliki Forest Virus RNA Replication Complex." Journal of Virology 75, no. 8 (2001): 3873–84. http://dx.doi.org/10.1128/jvi.75.8.3873-3884.2001.

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ABSTRACT The nonstructural (ns) proteins nsP1 to -4, the components of Semliki Forest virus (SFV) RNA polymerase, were localized in infected cells by confocal microscopy using double labeling with specific antisera against the individual ns proteins. All ns proteins were associated with large cytoplasmic vacuoles (CPV), the inner surfaces of which were covered by small invaginations, or spherules, typical of alphavirus infection. All ns proteins were localized by immuno-electron microscopy (EM) to the limiting membranes of CPV and to the spherules, together with newly labeled viral RNA. Along

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12

Kim, Deuk-Su, Yang Joo Kang, Kyung Jin Lee, et al. "A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure." International Journal of Molecular Sciences 21, no. 16 (2020): 5603. http://dx.doi.org/10.3390/ijms21165603.

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The antigen–antibody complex (AAC) has novel functions for immunomodulation, encouraging the application of diverse quaternary protein structures for vaccination. In this study, GA733 antigen and anti-GA733 antibody proteins were both co-expressed to obtain the AAC protein structures in a F1 plant obtained by crossing the plants expressing each protein. In F1 plant, the antigen and antibody assembled to form a large quaternary circular ACC structure (~30 nm). The large quaternary protein structures induced immune response to produce anticancer immunoglobulins G (IgGs) that are specific to the

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13

Romasanta, Pablo N., Lucrecia M. Curto, María B. Sarratea, et al. "Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules." Biochemical Journal 474, no. 1 (2016): 179–94. http://dx.doi.org/10.1042/bcj20160876.

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Natural killer (NK) cells are lymphocytes of the innate immune system that eliminate virally infected or malignantly transformed cells. NK cell function is regulated by diverse surface receptors that are both activating and inhibitory. Among them, the homodimeric Ly49 receptors control NK cell cytotoxicity by sensing major histocompatibility complex class I molecules (MHC-I) on target cells. Although crystal structures have been reported for Ly49/MHC-I complexes, the underlying binding mechanism has not been elucidated. Accordingly, we carried out thermodynamic and kinetic experiments on the i

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14

Sim, R. B., and S. A. Tsiftsoglou. "Proteases of the complement system." Biochemical Society Transactions 32, no. 1 (2004): 21–27. http://dx.doi.org/10.1042/bst0320021.

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The complement system is a group of about 35 soluble and cell-surface proteins which interact to recognize, opsonize and clear or kill invading micro-organisms or altered host cells (e.g. apoptotic or necrotic cells). Complement is a major part of the innate immune system. Recognition proteins such as C1q, MBL (mannan-binding lectin) and ficolins bind to targets via charge or sugar arrays. Binding causes activation of a series of serine protease proenzymes, such as C1r, C1s and MASP2 (MBL-associated serine protease 2), which in turn activate the atypical serine proteases factor B and C2, which

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Mavromatis, K., C. Kuyler Doyle, A. Lykidis, et al. "The Genome of the Obligately Intracellular Bacterium Ehrlichia canis Reveals Themes of Complex Membrane Structure and Immune Evasion Strategies." Journal of Bacteriology 188, no. 11 (2006): 4015–23. http://dx.doi.org/10.1128/jb.01837-05.

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ABSTRACT Ehrlichia canis, a small obligately intracellular, tick-transmitted, gram-negative, α-proteobacterium, is the primary etiologic agent of globally distributed canine monocytic ehrlichiosis. Complete genome sequencing revealed that the E. canis genome consists of a single circular chromosome of 1,315,030 bp predicted to encode 925 proteins, 40 stable RNA species, 17 putative pseudogenes, and a substantial proportion of noncoding sequence (27%). Interesting genome features include a large set of proteins with transmembrane helices and/or signal sequences and a unique serine-threonine bia

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Manna, Asit, Huaying Zhao, Junya Wada, et al. "Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation." Proceedings of the National Academy of Sciences 115, no. 51 (2018): E11914—E11923. http://dx.doi.org/10.1073/pnas.1817142115.

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The T cell antigen receptor encounters foreign antigen during the immune response. Receptor engagement leads to activation of specific protein tyrosine kinases, which then phosphorylate multiple enzymes and adapter proteins. One such enzyme, phospholipase-Cγ1, is responsible for cleavage of a plasma membrane lipid substrate, a phosphoinositide, into two second messengers, diacylglycerol, which activates several enzymes including protein kinase C, and an inositol phosphate, which induces intracellular calcium elevation. In T cells, phospholipase-Cγ1 is recruited to the plasma membrane as part o

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17

Cabiedes, Javier, Antonio R. Cabral, and Donato Alarcón-Segovia. "Hidden anti-phospholipid antibodies in normal human sera circulate as immune complexes whose antigen can be removed by heat, acid, hypermolar buffers or phospholipase treatments." European Journal of Immunology 28, no. 7 (1998): 2108–14. http://dx.doi.org/10.1002/(sici)1521-4141(199807)28:07<2108::aid-immu2108>3.0.co;2-r.

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18

Brandt, Sven, Krystin Krauel, Kay E. Gottschalk, et al. "Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in vitro prediction of antigenicity." Thrombosis and Haemostasis 112, no. 07 (2014): 53–64. http://dx.doi.org/10.1160/th13-08-0634.

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SummaryHeparin-induced thrombocytopenia (HIT) is the most frequent drug-induced immune reaction affecting blood cells. Its antigen is formed when the chemokine platelet factor 4 (PF4) complexes with polyanions. By assessing polyanions of varying length and degree of sulfation using immunoassay and circular dichroism (CD)-spectroscopy, we show that PF4 structural changes resulting in antiparallel β-sheet content >30% make PF4/polyanion complexes antigenic. Further, we found that polyphosphates (polyP-55) induce antigenic changes on PF4, whereas fondaparinux does not. We provide a model sugge

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Lalosevic, Dusan. "Acute renal pain as an adverse reaction of the rabies immunization." Medical review 62, no. 3-4 (2009): 133–35. http://dx.doi.org/10.2298/mpns0904133l.

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Introduction. HRIG is the best preparate in rabies prophylaxis, and it's considered that optimal dose is 20 international units per kilogram and must not been reduced or overdosed. HRIG have to be injected infiltrative around bite wounds, and if after that remains a part of the dose, it has to be given in gluteal muscle. Application only in gluteus is vitium artis. Case report. At one patient immunized against rabies has occured acute bilateral renal pain and fever at time of immunization against rabies, and because of that vaccination must been stopped after the 3rd dose of vaccine. Patient w

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20

Voiculescu, Mihai. "How Far we are towards Eradication of HBV Infection." Journal of Gastrointestinal and Liver Diseases 24, no. 4 (2015): 473–79. http://dx.doi.org/10.15403/jgld.2014.1121.244.hbv.

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Hepatitis B virus (HBV) infection is a major health problem with an important biological and a significant socio-economic impact all over the world. There is a high pressure to come up with a new and more efficient strategy against HBV infection, especially after the recent success of HCV treatment. Preventing HBV infection through vaccine is currently the most efficient way to decrease HBV-related cirrhosis and liver cancer incidence, as well as the best way to suppress the HBV reservoir. The vaccine is safe and efficient in 80-95% of cases. One of its most important roles is to reduce matern

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Jiao, Kexin, Laurence J. Walsh, Sašo Ivanovski, and Pingping Han. "The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells." International Journal of Molecular Sciences 22, no. 9 (2021): 4636. http://dx.doi.org/10.3390/ijms22094636.

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Periodontitis is a chronic complex inflammatory disease associated with a destructive host immune response to microbial dysbiosis, leading to irreversible loss of tooth-supporting tissues. Regeneration of functional periodontal soft (periodontal ligament and gingiva) and hard tissue components (cementum and alveolar bone) to replace lost tissues is the ultimate goal of periodontal treatment, but clinically predictable treatments are lacking. Similarly, the identification of biomarkers that can be used to accurately diagnose periodontitis activity is lacking. A relatively novel category of mole

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Crowley, Michael P., Ziv Reich, Nasim Mavaddat, John D. Altman та Yueh-hsiu Chien. "The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the γδ T Cell, G8". Journal of Experimental Medicine 185, № 7 (1997): 1223–30. http://dx.doi.org/10.1084/jem.185.7.1223.

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Recent studies have shown that many nonclassical major histocompatibility complex (MHC) (class Ib) molecules have distinct antigen-binding capabilities, including the binding of nonpeptide moieties and the binding of peptides that are different from those bound to classical MHC molecules. Here, we show that one of the H-2T region–encoded molecules, T10, when produced in Escherichia coli, can be folded in vitro with β2-microglobulin (β2m) to form a stable heterodimer in the absence of peptide or nonpeptide moieties. This heterodimer can be recognized by specific antibodies and is stimulatory to

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23

Scharf, Pablo, Milena Fronza Broering, Gustavo Henrique Oliveira da Rocha, and Sandra Helena Poliselli Farsky. "Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis." International Journal of Molecular Sciences 21, no. 19 (2020): 6996. http://dx.doi.org/10.3390/ijms21196996.

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Hematopoiesis is a complex and intricate process that aims to replenish blood components in a constant fashion. It is orchestrated mostly by hematopoietic progenitor cells (hematopoietic stem cells (HSCs)) that are capable of self-renewal and differentiation. These cells can originate other cell subtypes that are responsible for maintaining vital functions, mediate innate and adaptive immune responses, provide tissues with oxygen, and control coagulation. Hematopoiesis in adults takes place in the bone marrow, which is endowed with an extensive vasculature conferring an intense flow of cells.

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Liu, Hong, Walter F. Stafford, and Marlene Bouvier. "The Endoplasmic Reticulum Lumenal Domain of the Adenovirus Type 2 E3-19K Protein Binds to Peptide-Filled and Peptide-Deficient HLA-A*1101 Molecules." Journal of Virology 79, no. 21 (2005): 13317–25. http://dx.doi.org/10.1128/jvi.79.21.13317-13325.2005.

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ABSTRACT E3-19K is a type I membrane glycoprotein expressed by adenoviruses (Ads) to modulate host antiviral immune responses. We have developed an expression system for the endoplasmic reticulum lumenal domain (residues 1 to 100) of Ad type 2 E3-19K tagged with a C-terminal His6 sequence in baculovirus-infected insect cells. In this system, recombinant E3-19K is secreted into the culture medium. A characterization of soluble E3-19K by analytical ultracentrifugation and circular dichroism showed that the protein is monomeric and adopts a stable and correctly folded tertiary structure. Using a

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Han, Ji Won, and Eui-Cheol Shin. "Liver-Resident Memory CD8+ T Cells: Possible Roles in Chronic HBV Infection." International Journal of Molecular Sciences 22, no. 1 (2020): 283. http://dx.doi.org/10.3390/ijms22010283.

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Achieving a functional cure for chronic hepatitis B virus (HBV) infection or complete elimination of HBV covalently closed circular DNA (cccDNA) has been challenging in the treatment of patients with chronic HBV infection. Although novel antivirals are being investigated, improving HBV-specific adaptive immune responses is also important for durable viral clearance. Tissue-resident memory CD8+ T (TRM) cells were recently reported as a T-cell population that resides in peripheral tissues and does not recirculate. TRM cells have been studied in the livers of mice and humans. Liver TRM cells have

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Reittie, JE, D. Gottlieb, HE Heslop, et al. "Endogenously generated activated killer cells circulate after autologous and allogeneic marrow transplantation but not after chemotherapy." Blood 73, no. 5 (1989): 1351–58. http://dx.doi.org/10.1182/blood.v73.5.1351.1351.

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Abstract After marrow transplantation, major histocompatibility complex (MHC)- unrestricted natural killer (NK) lymphocytes are among the first cells to appear in the circulation. After T-cell-depleted bone marrow transplantation (TD-BMT), these cells have an activated pattern of target cell killing; they also secrete lymphokines including gamma- interferon (gamma-IFN), interleukin-2 (IL-2), and tumor necrosis factor (TNF) and may have a significant role as a primary defense against viral reactivation and in the elimination of residual host malignancy. We studied 43 patients with hematologic m

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Reittie, JE, D. Gottlieb, HE Heslop, et al. "Endogenously generated activated killer cells circulate after autologous and allogeneic marrow transplantation but not after chemotherapy." Blood 73, no. 5 (1989): 1351–58. http://dx.doi.org/10.1182/blood.v73.5.1351.bloodjournal7351351.

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After marrow transplantation, major histocompatibility complex (MHC)- unrestricted natural killer (NK) lymphocytes are among the first cells to appear in the circulation. After T-cell-depleted bone marrow transplantation (TD-BMT), these cells have an activated pattern of target cell killing; they also secrete lymphokines including gamma- interferon (gamma-IFN), interleukin-2 (IL-2), and tumor necrosis factor (TNF) and may have a significant role as a primary defense against viral reactivation and in the elimination of residual host malignancy. We studied 43 patients with hematologic malignancy

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Lu, ZY, H. Brailly, J. Wijdenes, R. Bataille, JF Rossi, and B. Klein. "Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments." Blood 86, no. 8 (1995): 3123–31. http://dx.doi.org/10.1182/blood.v86.8.3123.3123.

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Abstract A major limitation on the therapeutic use of cytokine antagonists is that the amount of cytokine to be neutralized in vivo is not presently known. We previously reported that anti-interleukin-6 (IL-6) monoclonal antibody (MoAb) administered to a patient with multiple myeloma (MM) induced high amounts of IL-6 to circulate in the form of monomeric immune complexes. Based on this observation, the present study developed a new methodology to estimate daily IL-6 production in 13 patients with MM or renal cancer who received anti-IL-6 MoAb. Treatment was considered effective when the produc

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Lu, ZY, H. Brailly, J. Wijdenes, R. Bataille, JF Rossi, and B. Klein. "Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments." Blood 86, no. 8 (1995): 3123–31. http://dx.doi.org/10.1182/blood.v86.8.3123.bloodjournal8683123.

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A major limitation on the therapeutic use of cytokine antagonists is that the amount of cytokine to be neutralized in vivo is not presently known. We previously reported that anti-interleukin-6 (IL-6) monoclonal antibody (MoAb) administered to a patient with multiple myeloma (MM) induced high amounts of IL-6 to circulate in the form of monomeric immune complexes. Based on this observation, the present study developed a new methodology to estimate daily IL-6 production in 13 patients with MM or renal cancer who received anti-IL-6 MoAb. Treatment was considered effective when the production of C

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Martin, Naomi, Xiaodie Tu, Alicia J. Egan, and Cordula Stover. "Complement Activation on Endothelial Cell-Derived Microparticles—A Key Determinant for Cardiovascular Risk in Patients with Systemic Lupus Erythematosus?" Medicina 56, no. 10 (2020): 533. http://dx.doi.org/10.3390/medicina56100533.

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Systemic lupus erythematosus is a classical systemic autoimmune disease that overactivates complement and can affect all organs. Early diagnosis and effective management are important in this immune-complex-mediated chronic inflammatory disease, which has a strong component of vasculitis and carries an increased risk of thrombosis, even in the absence of antiphospholipid antibodies. Development of lupus nephritis can be life limiting but is managed with dialysis and renal transplantation. Therefore, data have become available that cardiovascular risk poses a serious feature of systemic lupus e

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De La Pena, Hugo, J. Alejandro Madrigal, M. Bencsik, et al. "Artificial Super Para Magnetic Nano APC for Active and Adoptive Immunotherapy." Blood 108, no. 11 (2006): 3888. http://dx.doi.org/10.1182/blood.v108.11.3888.3888.

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Abstract T cells are probably one of the most pivotal cell types in the human adaptive immune system. They have the capability to eradicate primary, metastatic, relapsed tumours and can ameliorate otherwise fatal viral infections. Not surprisingly therefore, activation and expansion of T cells has become one of the main focuses for immunotherapy and immune gene therapy. Sufficient T cells numbers however, are required to deliver a significant clinical impact to patients, and rapid reproducible expansion of viable T cells still remains one of the main challenges for significant improvement. One

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Lee, Jaehyun, Cort B. Breuer, and Esak Lee. "Bioengineered in vitro models of leukocyte–vascular interactions." Biochemical Society Transactions 49, no. 2 (2021): 693–704. http://dx.doi.org/10.1042/bst20200620.

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Leukocytes continuously circulate our body through the blood and lymphatic vessels. To survey invaders or abnormalities and defend our body against them, blood-circulating leukocytes migrate from the blood vessels into the interstitial tissue space (leukocyte extravasation) and exit the interstitial tissue space through draining lymphatic vessels (leukocyte intravasation). In the process of leukocyte trafficking, leukocytes recognize and respond to multiple biophysical and biochemical cues in these vascular microenvironments to determine adequate migration and adhesion pathways. As leukocyte t

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Gentile and Antonelli. "HBV Reactivation in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Narrative Review." Viruses 11, no. 11 (2019): 1049. http://dx.doi.org/10.3390/v11111049.

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HBV reactivation (HBVr) can occur due to the ability of HBV to remain latent in the liver as covalently closed circular DNA and by the capacity of HBV to alter the immune system of the infected individuals. HBVr can occur in patients undergoing hematopoietic stem cell transplantation (HSCT) with a clinical spectrum that ranges from asymptomatic infection to fulminant hepatic failure. The risk of HBVr is determined by a complex interplay between host immunity, virus factors, and immunosuppression related to HSCT. All individuals who undergo HSCT should be screened for HBV. HSCT patients positiv

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Margos, Gabriele, Melissa R. van Dijk, Jai Ramesar, Chris J. Janse, Andrew P. Waters, and Robert E. Sinden. "Transgenic Expression of a Mosquito-Stage Malarial Protein, Pbs21, in Blood Stages of Transformed Plasmodium bergheiand Induction of an Immune Response upon Infection." Infection and Immunity 66, no. 8 (1998): 3884–91. http://dx.doi.org/10.1128/iai.66.8.3884-3891.1998.

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ABSTRACT Pbs21 is a surface protein of the ookinete of Plasmodium berghei, which can induce a potent transmission-blocking immune response. Pbs21 is normally expressed only by parasite stages in the mosquito, i.e., female gametes/zygotes, ookinetes, and oocysts. However, the Pbs21 gene is transcribed in female gametocytes which circulate in the bloodstream of the host, where translation of the resulting mRNA is totally repressed. Episomal transfection has been used to investigate whether expression of Pbs21 protein could be achieved in blood stages of the parasite. By using plasmid pMD221, the

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Kluczyk, Alicja, Marek Cebrat, Renata Zbozień-Pacamaj, et al. "On the peptide-antipeptide interactions in interleukin-1 receptor system." Acta Biochimica Polonica 51, no. 1 (2004): 57–66. http://dx.doi.org/10.18388/abp.2004_3596.

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Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively. Peptides of such sequence compete successfully with IL-1 for the cellular receptor. A pair of complementary peptides, based on the Siemion's hypothesis on the periodicity of the genetic code (QWLNIN and QWANIN), and another pair, in which, following the Root- Bernstein theory, Lys was used as complementary amino acid to Phe (QWLKIK and QWAKIK), were investigated for the peptide-antipeptide interactions using mass spectrometry (ESI-MS) and circular dich

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Zhang, Zhenfeng, and Stephan Urban. "Interplay between Hepatitis D Virus and the Interferon Response." Viruses 12, no. 11 (2020): 1334. http://dx.doi.org/10.3390/v12111334.

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Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, with rapid progression of liver-related diseases and high rates of development of hepatocellular carcinoma. The causative agent, hepatitis D virus (HDV), contains a small (approximately 1.7 kb) highly self-pairing single-strand circular RNA genome that assembles with the HDV antigen to form a ribonucleoprotein (RNP) complex. HDV depends on hepatitis B virus (HBV) envelope proteins for envelopment and de novo hepatocyte entry; however, its intracellular RNA replication is autonomous. In addition, HDV can amplify HBV independe

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Godderz, LeAnn J., and Karla K. Rodgers. "RAG1 oligomerization states and secondary structural properties: an initial characterization of V(D)J recombinase complex formation." Spectroscopy 18, no. 2 (2004): 311–22. http://dx.doi.org/10.1155/2004/572415.

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The recombination activating gene products (RAG1 and 2) catalyze the initial DNA cleavage steps during V(D)J recombination for the diversification of the immune repertoire. As the fundamental properties of the RAG proteins remain largely unknown, our objective is to investigate the self–association and conformational properties of RAG1. To analyze RAG1 association and dissociation, a time course of multi–angle laser light scattering measurements (MALL SEC) was performed on samples at different oligomerization states over a wide range of ionic strengths. The molecular masses of the predominant

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Matthews, Keith R., Richard McCulloch, and Liam J. Morrison. "The within-host dynamics of African trypanosome infections." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1675 (2015): 20140288. http://dx.doi.org/10.1098/rstb.2014.0288.

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African trypanosomes are single-celled protozoan parasites that are capable of long-term survival while living extracellularly in the bloodstream and tissues of mammalian hosts. Prolonged infections are possible because trypanosomes undergo antigenic variation—the expression of a large repertoire of antigenically distinct surface coats, which allows the parasite population to evade antibody-mediated elimination. The mechanisms by which antigen genes become activated influence their order of expression, most likely by influencing the frequency of productive antigen switching, which in turn is l

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Liu, Wanying, Sixue Bi, Chunlei Li, et al. "Purification and Characterization of a New CRISP-Related Protein from Scapharca broughtonii and Its Immunomodulatory Activity." Marine Drugs 18, no. 6 (2020): 299. http://dx.doi.org/10.3390/md18060299.

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More and more attention has been paid to bioactive compounds isolated from marine organisms or microorganisms in recent years. At the present study, a new protein coded as HPCG2, was purified from Scapharca broughtonii by stepwise chromatography methods. The molecular weight of HPCG2 was determined to be 30.71 kDa by MALDI-TOF-MS. The complete amino acid sequence of HPCG2 was obtained by tandem mass spectrometry combined with transcriptome database analysis, and its secondary structure was analyzed using circular dichroism. HPCG2 comprised 251 amino acids and contained 28.4% α-helix, 26% β-she

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Ailioaie, Laura Marinela, and Gerhard Litscher. "Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma." International Journal of Molecular Sciences 21, no. 19 (2020): 7150. http://dx.doi.org/10.3390/ijms21197150.

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Immune modulation is a very modern medical field for targeting viral infections. In the race to develop the best immune modulator against viruses, curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. As a bright yellow component of turmeric spice, curcumin has been the subject of thousands of scientific and clinical studies in recent decades to prove its powerful antioxidant properties and anticancer effects. Curcumin has been shown to influence inter- and intracellular signaling pathways, with direct effect

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Dragomir, Mihnea Paul, Scott Kopetz, Jaffer A. Ajani, and George Adrian Calin. "Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility." Gut 69, no. 4 (2020): 748–63. http://dx.doi.org/10.1136/gutjnl-2019-318279.

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One of the most unexpected discoveries in molecular oncology, in the last decades, was the identification of a new layer of protein coding gene regulation by transcripts that do not codify for proteins, the non-coding RNAs. These represent a heterogeneous category of transcripts that interact with many types of genetic elements, including regulatory DNAs, coding and other non-coding transcripts and directly to proteins. The final outcome, in the malignant context, is the regulation of any of the cancer hallmarks. Non-coding RNAs represent the most abundant type of hormones that contribute sign

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Chulanov, V. P., A. P. Zueva, D. S. Kostyushev, S. A. Brezgin, E. V. Volchkova, and V. V. Maleyev. "Hepatitis C can be cured: will hepatitis B become next?" Terapevticheskii arkhiv 89, no. 11 (2017): 4–13. http://dx.doi.org/10.17116/terarkh201789114-13.

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Chronic hepatitis B (CHB) and C (CHC) are one of the leading causes of cirrhosis and liver cancer with over a million of people dying annually from their consequences. In Russia CHB and CHC morbidity and related mortality show an upward trend. As a result of recent breakthroughs in antiviral therapeutics CHC became a curable disease. Modern therapeutics effectively suppress viral replication in CHB patients, but withdrawal of antivirals usually results in disease relapse. Loss of HBsAg required for the so called «functional cure» is a very rare event. Moreover, «complete cure» when the virus i

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Lande, Roberto, Immacolata Pietraforte, Anna Mennella, et al. "Complementary Effects of Carbamylated and Citrullinated LL37 in Autoimmunity and Inflammation in Systemic Lupus Erythematosus." International Journal of Molecular Sciences 22, no. 4 (2021): 1650. http://dx.doi.org/10.3390/ijms22041650.

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LL37 acts as T-cell/B-cell autoantigen in Systemic lupus erythematosus (SLE) and psoriatic disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading to type I interferon (IFN-I)/pro-inflammatory factors production. T-cell epitopes derived from citrullinated-LL37 act as better antigens than unmodified LL37 epitopes in SLE, at least in selected HLA-backgrounds, included the SLE-associated HLA-DRB1*1501/HLA-DRB5*0101 backgrounds. Remarkably, while “fully-citrullinated” LL37 acts as better T-cell-stimulator, it loses DNA-binding ability and the associated “adjuva

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Sapudom, Jiranuwat, Walaa Kamal E. Mohamed, Anna Garcia-Sabaté, et al. "Collagen Fibril Density Modulates Macrophage Activation and Cellular Functions during Tissue Repair." Bioengineering 7, no. 2 (2020): 33. http://dx.doi.org/10.3390/bioengineering7020033.

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Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into specific macrophage phenotypes to fulfill the immunological needs of tissues. During the tissue repair process, tissue density transits from loose to dense tissue. However, little is known on how changes in tissue density affects macrophage activation and their cellular functions. In this work, monocytic cell line THP-1 cells were embedded in three-dimensional (3D) collagen matrices with different fibril density and were then differentiated into uncommitted macrophages (MPMA) using phorbol-12-myristate-1

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Cohen, J. D., H. W. Kao, S. T. Tan, J. Lechago, and W. J. Snape. "Effect of acute experimental colitis on rabbit colonic smooth muscle." American Journal of Physiology-Gastrointestinal and Liver Physiology 251, no. 4 (1986): G538—G545. http://dx.doi.org/10.1152/ajpgi.1986.251.4.g538.

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The membrane potential and contractile activity of colonic circular smooth muscle from New Zealand White rabbits were studied after the production of acute experimental colitis. Colitis was induced in the distal colon by rectal infusion of formaldehyde solution, followed by an intravenous bolus of soluble immune complexes. Despite active mucosal inflammation, there are only occasional inflammatory cells in the muscularis. Electrophysiological studies on tissue from control rabbits and rabbits with colitis were performed using double sucrose gap and intracellular microelectrode techniques. The

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Shevchenko, Dmitriy V., Timothy J. Sellati, David L. Cox, Olga V. Shevchenko, Esther J. Robinson, and Justin D. Radolf. "Membrane Topology and Cellular Location of the Treponema pallidum Glycerophosphodiester Phosphodiesterase (GlpQ) Ortholog." Infection and Immunity 67, no. 5 (1999): 2266–76. http://dx.doi.org/10.1128/iai.67.5.2266-2276.1999.

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ABSTRACT Recent reports that isolated Treponema pallidum outer membranes contain an ortholog for glycerophosphodiester phosphodiesterase (GlpQ) (D. V. Shevchenko, D. R. Akins, E. J. Robinson, M. Li, O. V. Shevchenko, and J. D. Radolf, Infect. Immun. 65:4179–4189, 1997) and that this protein is a potential opsonic target for T. pallidum (C. E. Stebeck, J. M. Shaffer, T. W. Arroll, S. A. Lukehart, and W. C. Van Voorhis, FEMS Microbiol. Lett. 154:303–310, 1997) prompted a more detailed investigation of its physicochemical properties and cellular location. [14C]palmitate radiolabeling studies of a

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Beerens, Dior, Sandra Franch-Arroyo, Timothy J. Sullivan, Christian Goosmann, Volker Brinkmann, and Emmanuelle Charpentier. "Survival Strategies of Streptococcus pyogenes in Response to Phage Infection." Viruses 13, no. 4 (2021): 612. http://dx.doi.org/10.3390/v13040612.

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Bacteriophages exert strong evolutionary pressure on their microbial hosts. In their lytic lifecycle, complete bacterial subpopulations are utilized as hosts for bacteriophage replication. However, during their lysogenic lifecycle, bacteriophages can integrate into the host chromosome and alter the host’s genomic make-up, possibly resulting in evolutionary important adjustments. Not surprisingly, bacteria have evolved sophisticated immune systems to protect against phage infection. Streptococcus pyogenes isolates are frequently lysogenic and their prophages have been shown to be major contribu

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Hase, Manuela E., Nikolai V. Kuznetsov, and Volker C. Cordes. "Amino Acid Substitutions of Coiled-Coil Protein Tpr Abrogate Anchorage to the Nuclear Pore Complex but Not Parallel, In-Register Homodimerization." Molecular Biology of the Cell 12, no. 8 (2001): 2433–52. http://dx.doi.org/10.1091/mbc.12.8.2433.

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Tpr is a protein component of nuclear pore complex (NPC)-attached intranuclear filaments. Secondary structure predictions suggest a bipartite structure, with a large N-terminal domain dominated by heptad repeats (HRs) typical for coiled-coil–forming proteins. Proposed functions for Tpr have included roles as a homo- or heteropolymeric architectural element of the nuclear interior. To gain insight into Tpr's ultrastructural properties, we have studied recombinant Tpr segments by circular dichroism spectroscopy, chemical cross-linking, and rotary shadowing electron microscopy. We show that polyp

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Fan, Shuhua, Yanan Wu, Song Wang, et al. "Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains." Journal of Virology 90, no. 15 (2016): 6625–41. http://dx.doi.org/10.1128/jvi.00119-16.

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ABSTRACTThe lack of a peptide-swine leukocyte antigen class I (pSLA I) complex structure presents difficulties for the study of swine cytotoxic T lymphocyte (CTL) immunity and molecule vaccine development to eliminate important swine viral diseases, such as influenza A virus (IAV). Here, after cloning and comparing 28 SLA I allelic genes from Chinese Heishan pigs, pSLA-3*hs0202 was crystalized and solved. SLA-3*hs0202 binding with sβ2m and a KMNTQFTAV (hemagglutinin [HA]-KMN9) peptide from the 2009 pandemic swine H1N1 strain clearly displayed two distinct conformations with HA-KMN9 peptides in

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Xie, Y. N., W. T. Gerthoffer, S. N. Reddy, F. Cominelli, V. E. Eysselein, and W. J. Snape. "An abnormal rate of actin myosin cross-bridge cycling in colonic smooth muscle associated with experimental colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 5 (1992): G921—G926. http://dx.doi.org/10.1152/ajpgi.1992.262.5.g921.

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Previous studies showed that colonic smooth muscle develops less contractile force to neurohumoral stimulation when associated with mucosal inflammation. This study evaluated 1) the Ca2+ dependence for colonic smooth muscle contraction, 2) the maximum velocity of muscle shortening (Vmax), and 3) changes in 20-kDa myosin light-chain (MLC) phosphorylation in distal circular colonic muscle from healthy rabbits and from rabbits with experimental colitis, induced by Formalin and immune complexes. The isometric tension of unskinned muscle stimulated with bethanechol or KCl was less (P less than 0.05

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