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1

Augustin, Goran. Acute appendicitis in pregnancy. Nova Science Publishers, 2010.

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2

L, Krähenbühl, ed. Acute appendicitis: Standard treatment or laparoscopic surgery? Karger, 1998.

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3

KEYZER, Caroline, and Pierre Alain Gevenois, eds. Imaging of Acute Appendicitis in Adults and Children. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-17872-6.

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4

Medical Research Council. Environmental Epidemiology Unit., ed. The aetiology of acute appendicitis: Proceedings of a meeting held on 22nd May 1986 at the MRC Environmental Epidemiology Unit. Southampton General Hospital, 1986.

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5

Scordino, David. Appendicitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0036.

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Appendicitis is caused by acute inflammation of the appendix (usually secondary to obstruction) and can result in perforation, leading to peritonitis, sepsis, and/or abscess formation. Symptomatology includes anorexia, nausea, vomiting, and periumbilical pain (later localizing to the right lower quadrant). Patients at the extremes of age and pregnant women may have atypical presentations and higher rates of perforation and complications. Most patients suspected of having appendicitis receive prompt surgical intervention (usually laparoscopic). Antibiotic therapy, initiated preoperatively, vari
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6

Kwon, Rachel J. Laparoscopic versus Open Appendectomy. Edited by Danny Sherwinter and Miguel A. Burch. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199384075.003.0036.

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This chapter provides a summary of a landmark study in minimally invasive surgery. Compared with open appendectomy, does laparoscopic appendectomy for acute appendicitis offer any advantage with respect to recovery, complications, or return to normal activities? Starting with that question, it describes the basics of the study, including year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information,
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7

Catanzaro, Michael P., and Rachel J. Kwon. Acute Appendicitis. Edited by Rachel J. Kwon. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199384075.003.0049.

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This chapter provides a summary of a landmark historical study in surgery involving management and treatment of acute appendicitis. It describes the history of the disease, gives a summary of the study including study design and results, and relates the study to a modern-day principle of evidence-based medicine: observational studies in study design. Reginald H. Fitz’s insights over a century ago in a seminal case series regarding the nature of appendicitis, its potential sequelae, and the value of urgent surgical intervention changed the disease from a deadly one into one that can be easily c
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8

Kr�henb�hl, L., E. Frei, C. Klaiber, and M. W. B�chler, eds. Acute Appendicitis: Standard Treatment or Laparoscopic Surgery? S. Karger AG, 1998. http://dx.doi.org/10.1159/isbn.978-3-318-00270-6.

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9

Lee, Christoph I. Multidetector CT for Acute Appendicitis in Adults. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0027.

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This chapter, found in the abdominal and pelvic pain section of the book, provides a succinct synopsis of a key study examining the use of multidetector computed tomography for diagnosing acute appendicitis in adults. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. This technique was shown to reduce rates of perforation and negative findings at appendectomy when incorporated into routine diagnostic algorithms, and can redirect management for patients with alternative diagno
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10

Guttadauro, Angelo. Doubts, Problems and Certainties about Acute Appendicitis. Intechopen, 2022.

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11

Gevenois, Pierre Alain, and Caroline KEYZER. Imaging of Acute Appendicitis in Adults and Children. Springer, 2016.

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12

Gevenois, Pierre Alain, and Caroline KEYZER. Imaging of Acute Appendicitis in Adults and Children. Springer, 2011.

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13

Imaging Of Acute Appendicitis In Adults And Children. Springer, 2011.

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14

Doubts, Problems and Certainties about Acute Appendicitis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.91502.

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15

Beattie, Mark, and Mike Stanton. Acute abdominal pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0041.

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16

Garbuzenko, Dmitry Victorovich, ed. Current Issues in the Diagnostics and Treatment of Acute Appendicitis. InTech, 2018. http://dx.doi.org/10.5772/intechopen.70917.

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17

Garbuzenko, Dmitry Victorovich. Current Issues in the Diagnostics and Treatment of Acute Appendicitis. IntechOpen, 2018.

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18

Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Acute abdominal pain. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0036.

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Introduction 252Appendicitis 253Intussusception 253Miscellaneous conditions 254The commonest surgical diagnosis in children who present to hospital with acute abdominal pain is appendicitis. The differential diagnosis is wide, however (see box below), and in >50% of admissions no specific cause is found....
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19

Lee, Christoph I. Imaging Appendicitis in Children. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0025.

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This chapter, found in the abdominal and pelvic pain section of the book, provides a succinct synopsis of a key study examining the use of ultrasound and computed tomography (CT) among children with suspected appendicitis. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The study showed that CT with contrast after a negative or indeterminate pelvic ultrasound leads to very high accuracy in diagnosing acute appendicitis in children. In addition to outlining the most salient
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20

Krahenbuhl, L. Acute Appendicitis: Standard Treatment and the Role of Laparoscopic Surgery (Progress in Surgery). S. Karger Publishers (USA), 1998.

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21

Quinlivan, Ros, and Pascal Laforêt. Chronic Fatigue and Acute Rhabdomyolysis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0068.

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Chronic fatigue syndrome is usually idiopathic, management involves a multi-disciplinary approach, advice on pacing activities and cognitive behavioral therapy. Metabolic myopathies that cause exercise intolerance may lead to a fatigue syndrome due to deconditioning, other neuromuscular disorders presenting with paroxysmal fatigue and weakness such as the myasthenic syndromes and channelopathies can occasionally be mistaken for a metabolic disorder. Acute rhabdomyolysis, a potentially life-threatening complication, has many causes both acquired and genetic. Urgent treatment is required and pre
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22

Freda, Benjamin J., and Gregory L. Braden. Other toxic acute tubulointerstitial nephritis. Edited by Adrian Covic. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0085.

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Chronic kidney disease (CKD) is often the result of incomplete recovery of renal function from a variety of causes of acute tubulointerstitial injury. Exposure to ethylene glycol, chlorinated hydrocarbons, paraquat, or toxic mushrooms often causes severe acute kidney injury (AKI), leading to chronic tubulointerstitial nephritis (TIN) and CKD, including end-stage renal disease. Ethylene glycol intoxication often leads to chronic TIN and CKD from direct renal tubular toxicity and from interstitial calcium oxalate deposition. Chlorinated hydrocarbon exposure can cause dialysis-dependent AKI, but
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23

Brown, Jeremiah R., and Chirag R. Parikh. Cardiovascular surgery and acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0245.

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Over the last decade, cardiac surgery-associated acute kidney injury (AKI) has been recognized as a frequent adverse event following cardiac surgery. In this clinical context and others, AKI has been strongly associated with increased morbidity, mortality, and length of hospitalization. These adverse events that accompany AKI have been shown to be directly proportional to the magnitude of the peak rise in serum creatinine and the duration of AKI making AKI a costly complication and a target for prevention in hospitalized patients around the world. This chapter discusses the subsequent healthca
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24

Manners, Jody, Kiruba Dharaneeswaran, and Ruchira Jha. Approach to Acute Altered Mental Status and Seizures (DRAFT). Edited by Raghavan Murugan and Joseph M. Darby. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190612474.003.0007.

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Altered mental status (AMS) is a common presenting symptom or complication in hospitalized patients. The etiology of AMS includes potential primary neurologic entities as well as systemic disturbances such as infection, intoxication, or metabolic derangement. A systematic and rapid evaluation of potentially life threatening conditions is necessary to guide appropriate management. Seizures (particularly non-convulsive episodes) are an important cause of AMS frequently encountered in acutely ill patients with multiple medical comorbidities and need to be recognized and treated early to minimize
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25

Golper, Thomas A., Andrew A. Udy, and Jeffrey Lipman. Drug dosing in acute kidney injury. Edited by William G. Bennett. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0364.

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Drug dosing in acute kidney injury (AKI) is one of the broadest topics in human medicine. It requires an understanding of markedly altered and constantly changing physiology under many disease situations, the use of the drugs to treat those variety of diseases, and the concept of drug removal during blood cleansing therapies. Early in AKI kidney function may be supraphysiologic, while later in the course there may be no kidney function. As function deteriorates other metabolic pathways are altered in unpredictable ways. Furthermore, the underlying disorders that lead to AKI alter metabolic pat
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26

Paul, Richard. Ultrasound-guided vascular access in intensive/acute cardiac care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0021.

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Vascular access is an essential requirement for the care of the critically ill cardiac patient, being necessary for drug and fluid delivery and monitoring of a patient’s haemodynamic response to an instigated therapy. The most common vascular access procedures conducted in the acute cardiac care unit are central venous and peripheral venous access, and arterial cannulation. Traditional landmark methods are associated with complication rates, ranging from 18 to 40%, depending on the site of access. The use of ultrasound to guide venous and arterial access has been shown to reduce the incidence
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27

Jörres, Achim, Dietrich Hasper, and Michael Oppert. Non-dialytic management of the patient with acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0228.

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The main focus in the non-dialytic management of patients with acute kidney injury (AKI) is the prevention and treatment of complications.Nutritional support is an important aspect as many patients tend to be hypercatabolic, thus requiring adequate caloric intake, yet without administration of excessive fluid volumes. Inadequate nutrition in AKI may lead to enhanced production of urea nitrogen and azotaemia. However, hyperglycaemia is a frequent complication in these patients, often requiring continuous insulin therapy to achieve the recommended blood glucose target range of 110–150 mg/dL (6.1
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28

Stacey, Victoria. Surgery. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199592777.003.0006.

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The acute abdomen - Biliary tract disorders - Acute pancreatitis - Appendicitis - Bowel obstruction - Bowel perforation - Bowel ischaemia/infarction - Abdominal aortic aneurysm - Aortic dissection - Acute limb ischaemia - Haematuria - Renal colic - Urinary tract infections - Testicular torsion - Priapism - Fournier’s gangrene - SAQs
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29

Janzing, Heinrich M. J. The Acute Compartment Syndrome, a Complication of Fractures and Soft Tissue Injuries of the Extremities: A Clinical Study About Diagnosis and Treatment ... Syndrome (Acta Biomedica Lovaniensia, 199). Not Avail, 1999.

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30

Gardiner, Matthew D., and Neil R. Borley. Emergency surgery. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199204755.003.0008.

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This chapter begins by discussing the basic principles of Advanced Trauma Life Support, care of the critically ill surgical patient, shock, SIRS and sepsis, and blood products and transfusion, before focusing on the key areas of knowledge, namely traumatic head injury, spine and spinal cord trauma, maxillofacial trauma, cardiothoracic trauma, abdominal trauma, urological trauma, vascular trauma, assessment of the acute abdomen, acute appendicitis, acute upper gastrointestinal haemorrhage, lower gastrointestinal haemorrhage, gastrointestinal obstruction, gastrointestinal perforation, acute panc
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31

Carton, James. Gastrointestinal pathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759584.003.0007.

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This chapter discusses gastrointestinal pathology, including gastrointestinal malformations, oesophagitis, oesophageal polyps and nodules, oesophageal carcinoma, gastritis, gastric polyps, gastric carcinoma, gastrointestinal stromal tumours, peptic duodenitis, coeliac disease, small bowel infarction, intestinal infections, intestinal obstruction, acute appendicitis, Crohn’s disease, ulcerative colitis, colorectal polyps, colorectal carcinoma, diverticular disease, and anal pathology.
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32

Lachmann, Robin H., and Elaine Murphy. Emergencies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0076.

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Patients with an inherited metabolic disease can present acutely either with a metabolic decompensation, or due to an emerging complication. In either case, it is important to recognize the underlying metabolic condition as disease specific management is likely to be necessary. In this chapter we discuss some of the more prequent acute presentations which can be seen in adults with IMDs.
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33

Beed, Martin, Richard Sherman, and Ravi Mahajan. Gastrointestinal and hepatic. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199696277.003.0008.

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Gastrointestinal haemorrhageAcute severe pancreatitisThe acute abdomenAcute bowel ischaemiaIntra-abdominal hypertensionHepatic failure, hepatic encephalopathy, and hepatorenal syndromeHaemorrhage may occur in the upper (oesophagus, stomach, or duodenum) or lower GI tract (small bowel or colon). Severity can vary greatly from trivial to immediately life-threatening. It may be the cause of critical care admission, or occur as a complication of ICU care....
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34

Cohen, Jeffrey A., Justin J. Mowchun, Victoria H. Lawson, and Nathaniel M. Robbins. A 41-Year-Old Male with Foot Drop and Malaise. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190491901.003.0018.

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Distal, symmetric polyneuropathy can occur in a number of conditions including in association with HIV infection. The most common neurologic complication of HIV infection is a painful, distal sensory polyneuropathy (HIV-DSP). Other neuromuscular manifestations of HIV are myriad especially in the setting of fluctuating immunocompetence and the potential impact of neurotoxic medications. In the patient described in the case, peroneal neuropathy as the cause for foot drop is suggested by ankle dorsiflexion and eversion weakness with preservation of inversion and knee flexion strength. Mononeuropa
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35

Kashani, Kianoush B., and Amy W. Williams. Renal Failure. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0473.

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Renal failure is caused by acute kidney injury or chronic kidney disease. Acute kidney injury (AKI) is a common, devastating complication that increases mortality and morbidity among patients with various medical and surgical illnesses. Also known as acute renal failure, AKI is a rapid deterioration of kidney function that results in the accumulation of nitrogenous metabolites and medications and in electrolyte and acid-base imbalances. This chapter discusses the definition, epidemiology, pathophysiology, and etiology of AKI; the clinical approach to patients with AKI; and the management of AK
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36

Prowle, John R. Renal injury biomarkers in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0302.

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Acute kidney injury (AKI) is a common complication of critical illness and its occurrence has been independently associated with both short- and longer-term morbidity and mortality. However, conventional diagnosis of AKI, based on rises in serum creatinine, can be delayed and inaccurate, particularly in the context of critical illness. These diagnostic limitations potentially prevent timely intervention and appropriate follow-up of patients experiencing AKI. Recently, a number of novel urinary and serum biomarkers of AKI have been described that may provide earlier and more precise diagnosis.
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37

Bunch, Chris. Myelodysplasia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0288.

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The myelodysplastic syndromes (or myelodysplasias) comprise a spectrum of disorders characterized by dysplastic or ineffective haemopoiesis that leads to variable anaemia, neutropenia, and thrombocytopenia. There is often a degree of red-cell macrocytosis. The majority are clonal stem cell disorders in which the abnormal clone predominates and expands only slowly over a number of years. Myelodysplasias have a tendency to develop ultimately into acute leukaemia in some patients; for this reason, they are sometimes referred to as ‘preleukaemias’, even though two-thirds of patients will never dev
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38

Alvis, Bret, and Amy Robertson. Hepatic Encephalopathy. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0075.

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Hepatic encephalopathy is a complication of both acute and chronic liver failure. The disease can range from mild cognitive deficits to deep coma. Ammonia accumulation and inflammation are the two most accepted causes of hepatic encephalopathy. It is important to confirm an elevated serum ammonia level and rule out alternative causes of neurological derangements. Nonabsorbable disaccharides are the mainstay of treatment; however, the only definitive treatment is liver transplantation. Pertinent anesthetic considerations include avoiding benzodiazepines, understanding the implications of dimini
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39

Wiles, Kate, and Catherine Nelson-Piercy. Pre-eclampsia and related disorders. Edited by Norbert Lameire and Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0296_update_001.

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Pre-eclampsia is a pregnancy-specific condition diagnosed by new-onset hypertension and proteinuria after 20 weeks’ gestation. The incidence of pre-eclampsia means that it is both the most prevalent cause of acute kidney injury (AKI) in pregnancy and the commonest glomerular disease in the world. This chapter outlines the diagnosis and management of pre-eclampsia. Particular emphasis is given to the post-partum disease course as this is when a specialist nephrology opinion may be sought. HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome is a variant of severe pre-eclampsia. Th
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40

Schneider, Antoine G., Neil J. Glassford, and Rinaldo Bellomo. Choice of Renal Replacement Therapy and Renal Recovery. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0038.

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Acute kidney injury (AKI) is a major complication of critical illness, associated with increased mortality and morbidity. Among survivors of AKI, a subset will develop the need for chronic dialysis. Chronic dialysis imposes a major physical, emotional, economic, and social burden on ICU survivors and their caregivers. Evidence suggests that the type of renal replacement therapy used in the acute setting may affect renal recovery differently. For example, intermittent haemodialysis (IHD) increases the risk of hypotension and acute volume and solute fluctuations, and such physiological events ha
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41

Christine, Roffe. Stroke care: what is in the black box? Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199689644.003.0014.

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Key points• Most improvements in stroke care to date have been driven by research.• Immediate access to advanced imaging allows fast decision making, is cost-effective, and improves outcome.• Hyperacute interventions for acute ischaemic and haemorrhagic stroke can prevent permanent brain damage and reduce disability.• Strokes and stroke complications do not just happen during working hours: 24/7 working is essential for effective stroke management.• High quality nursing care is essential and has been shown to have a major impact on survival.• Pneumonia is the most common post-stroke complicati
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42

Drennan, Kathryn J., and Maria Vanushkina. Spinal Cord Injury in Pregnancy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0029.

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Spinal cord injury is an uncommon complication of pregnancy. But women with spinal cord injuries should be counseled that successful pregnancy is possible. Pregnancies should be planned once the patient has reached optimal functional status. At the outset of pregnancy, complications should be planned for, and an overall functional and routine health maintenance assessment should be evaluated. Providers should pay particular attention to voiding and elimination management, prevention of urinary tract infection, respiratory complications, and autonomic dysreflexia. Urinary complications can be d
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43

Mabey, David, Hasan E. Baydoun, and Jamil D. Bayram. Prosthetic Joint Infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0048.

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Prosthetic joint infection (PJI), a complication of joint replacement surgery, presents with fever, joint pain, erythema, effusion, and joint loosening. Many advances have decreased the risk of infection, such as the use of perioperative antimicrobial prophylaxis and intraoperative laminar airflow. Joint fluid analysis should be pursued by the orthopedic surgeons; primary and acute care providers should consult the definitive care team and refer these patients for admission. Organisms causing prosthetic joint infections often grow in biofilms, which make them difficult to treat. Surgical treat
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44

Abhishek, Abhishek, and Michael Doherty. Treatment of calcium pyrophosphate deposition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0052.

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The treatment of calcium pyrophosphate crystal deposition (CPPD) is mainly symptomatic. Acute calcium pyrophosphate (CPP) crystal synovitis should be treated with rest, local application of ice packs, joint aspiration, and/or intra-articular corticosteroid injection (once joint sepsis has been excluded). Oral colchicine or prednisolone may be used if joint aspiration and/or injection are not feasible. Anti-inflammatory agents (with proton pump inhibitors) may be used but in general these should be avoided as most patients with acute CPP crystal arthritis are elderly, and at a high risk of gast
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45

Rodríguez-Iturbe, Bernardo, and Mark Haas. Post-streptococcal glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0077_update_001.

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Post-streptococcal glomerulonephritis is a complication of Streptococcal infections that is responsible for classic acute nephritic syndrome, mostly seen in children. This is an acute nephritis associated with prominent fluid retention and oedema, hypertension and haematuria. Serum complement levels are diagnostically helpful as C3 levels are characteristically very low. However, many cases are much less severe and may pass unrecognized, only being identified by screening for dipstick haematuria. In children recovery is the rule but in adults, often with comorbid conditions, the prognosis is s
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46

Crawford, Laura, and Ruth Kleinpell. Principles and prevention of pressure sores in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0279.

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A pressure ulcer, defined by the National Pressure Advisory Panel and European Pressure Ulcer Advisory Panels as localized injury to the skin or tissue as the result of pressure or pressure in combination with shear, can be an adverse complication of a hospital stay, especially for acute and critically-ill patients. Factors that can contribute to pressure ulcer development include the intensity and duration of pressure, tissue tolerance, shear, and friction. Common anatomical sites for pressure ulcers development are over bony prominences. The National Pressure Advisory Panel and European Pres
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47

Menon, Ashok, Haris A. Khwaja, Ariel Ortiz Lagardere, Manoel Galvao Neto, and Jaime Ponce. Complications of the Intragastric Balloon. Edited by Tomasz Rogula, Philip Schauer, and Tammy Fouse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190608347.003.0038.

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Intragastric balloons (IGB) have been used in the treatment of obesity for over 30 years. The first notable IGB device (the Garren Edwards Gastric Bubble) was withdrawn from the market due to patients’ poor weight loss and a high rate of complications. Several subsequent devices have been designed to address these shortcomings, but high-quality data are needed to compare complication rates among devices. Mortality across all IGB variants is extremely low compared to other bariatric procedures. Complications are mainly associated with visceral injury related to device insertion and retrieval, a
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48

Jones, Alison L. Management of opioid poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0319.

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Opioids are ‘morphine like’ substances that have actions at specific opioid receptors (especially µ receptors) in the central nervous system (CNS). Tolerance of respiratory depression develops at a slower rate than analgesic tolerance, placing patients with a long history of opioid use at particular risk for respiratory depression. If chronic users abruptly stop taking opioids, they develop an acute withdrawal syndrome. Most opioid toxicity is the result of inadvertent overdosage during recreational use or in self-harm, but it can also be due to medication misuse and drug errors. It is charact
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49

Latronico, Nicola, Simone Piva, and Victoria McCredie. Long-Term Implications of ICU-Acquired Muscle Weakness. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0024.

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Intensive care unit-acquired weakness (ICUAW) is a significant and common complication with major implications for survivors of critical illness. ICUAW is a clinical diagnosis made in the presence of generalized muscle weakness that occurs in the setting of critical illness when other causes of muscle weakness have been excluded. Critical illness polyneuropathy and myopathy are the most common causes of ICUAW. Short-term implications of ICUAW include alveolar hypoventilation and an increased risk of pulmonary aspiration, atelectasis, and pneumonia—factors which may contribute to acute respirat
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50

Rodriguez-Iturbe, Bernardo, and Mark Haas. Glomerulonephritis associated with endocarditis, deep-seated infections, and shunt nephritis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0079_update_001.

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Endocarditis is a cause of glomerulonephritis. Healthcare interventions (prosthetic valves, indwelling catheters, pacemaker wires) and intravenous drug abuse are presently the most common causes of endocarditis and Staphylococcus aureus is frequently the infecting bacteria. Shunt nephritis is a form of glomerulonephritis associated with infection of ventriculoatrial shunts implanted to relieve hydrocephalus and, typically, are caused by prolonged infections of low-pathogenicity microorganisms. This complication led to the replacement of the technique by ventriculoperitoneal shunts. Deep-seated
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