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Journal articles on the topic 'Compound identification'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Li, Hong Zheng, He Zhou, and Yao Hong Jin. "A Method for Identifying V+N Compound Nouns in Patent Machine Translation." Applied Mechanics and Materials 513-517 (February 2014): 4617–20. http://dx.doi.org/10.4028/www.scientific.net/amm.513-517.4617.

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In this paper, we introduced one kind of special compound noun in Chinese patent texts composed of verb and noun, and presented a rule-based method for Chinese-English patent Machine Translation (MT) to improve the identification of compound nouns, with the purpose of decreasing the possibilities that verbs may disturb the identification of core predicate verb. The system first tagged different weights on verbs then determined the properties of verbs and recognized the compounds according to the weights. We then conducted experiments with the method, which proved that the method could identify

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2

Opialla, Tobias, Stefan Kempa, and Matthias Pietzke. "Towards a More Reliable Identification of Isomeric Metabolites Using Pattern Guided Retention Validation." Metabolites 10, no. 11 (2020): 457. http://dx.doi.org/10.3390/metabo10110457.

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Reliable analyte identification is critical in metabolomics experiments to ensure proper interpretation of data. Due to chemical similarity of metabolites (as isobars and isomers) identification by mass spectrometry or chromatography alone can be difficult. Here we show that isomeric compounds are quite common in the metabolic space as given in common metabolite databases. Further, we show that retention information can shift dramatically between different experiments decreasing the value of external or even in-house compound databases. As a consequence the retention information in compound da

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3

Bowes, Scott, Dongyu Sun, Azita Kaffashan, et al. "Quality Assessment and Analysis of Biogen Idec Compound Library." Journal of Biomolecular Screening 11, no. 7 (2006): 828–35. http://dx.doi.org/10.1177/1087057106290993.

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A subset of the compound repository for lead identification at Biogen Idec was characterized for its chemical stability over a 3-year period. Compounds were stored at 4 °C as 10 mM DMSO stocks, and a small subset of compounds was stored as lyophilized dry films. Compound integrity of 470 discrete compounds (Compound Set I) and 1917 combinatorial chemistry-derived compounds (Compound Set II) was evaluated by liquid chromatography/mass spectrometry from the time of acquisition into the library collection and after 3 years of storage. Loss of compound integrity over the 3 years of storage was obs

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4

T. Khalaf, Kawther. "Isolation and Identification of two bioactive compounds from basidiomycetes fungus Coprinus sp." University of Thi-Qar Journal of Science 5, no. 2 (2015): 54–58. http://dx.doi.org/10.32792/utq/utjsci/v5i2.122.

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The fungus Coprinus sp. was isolated and cultivation in laboratory on two PDA medium with some growthinduction .Two bioactive chemical compounds were isolated and purified from mycelial culture of Coprinus sp. byusing potato dextrose agar and potato dextrose broth . The two compounds were identified by using GC-mass technique .The molecular weight of purified compounds 1 and 2 were 352 KD and 388 KD respectively and chemical formula of compound 1 is C21H24N2O3 which isolated from solid medium while compound 2 is C24H26O4 which isolated from broth medium . The antibacterial activity of the puri

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5

Mawardi, Mawardi. "Isolation and Identification of Secondary Metabolic Compounds Acetone Extract from Dutch Eggplant (Cyphomandra betacea)." Jurnal Matematika Dan Ilmu Pengetahuan Alam LLDikti Wilayah 1 (JUMPA) 2, no. 2 (2022): 87–93. http://dx.doi.org/10.54076/jumpa.v2i2.230.

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Isolation and identification of secondary metabolite compound in acetone extract from fruit terong belanda (Cyphomandra betacea) have been carried out. The aim of this research is to isolate and identify the secondary metabolite compound in acetone extract from fruit terong belanda (Cyphomandra betacea) which obtain from Enrekang. The compound was obtained by isolation process that consist of several stages, including extraction, fractination, purification and identification. Extraction was carried out using maceration with acetone. The identification was coment by is color test, melt point, s

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6

Sudirman, Sabri, Nurjanah Nurjanah, and Agoes Mardiono Jacoeb. "Identification of Antioxidant Compounds Structure Large-Leafed Mangrove Fruit." Jurnal Pengolahan Hasil Perikanan Indonesia 19, no. 2 (2016): 94. http://dx.doi.org/10.17844/jphpi.v19i2.13452.

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Antioxidants are compounds that can inhibit or prevent the oxidation of the easily oxidized substrate.<br />One of the plants as a potential source of bioactive compounds and antioxidant activity is large-leafed<br />mangrove (Bruguiera gymnorrhiza). This plant is commonly found in the Pacific region of Southeast Asia,<br />Ryukyu Islands, Micronesia and Polynesia (Samoa) to subtropical regions of Australia and has been used<br />by the society. This study aimed to determine the bioactive compounds structure of large-leafed mangrove<br />has the highest antioxidan

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7

Hakim, Aliefman, Jamaluddin Jamaluddin, I. Nyoman Loka, Saprizal Hadisaputra, and Ayu Rizki Mujiyanti. "Acid-Base Extraction of Anacardic Acid from Cashew Seed Shell." Jurnal Pijar Mipa 16, no. 3 (2021): 418. http://dx.doi.org/10.29303/jpm.v16i3.2595.

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Research on the isolation of anacardic acid compounds from cashew nut shells has been carried out. This study aims to develop a method of isolating anacardic acid compounds from cashew nut shells in an easier way but still produces compounds that remain pure. In this study isolation and identification of anacardic acid compounds contained in CNSL was carried out. The results of anacardic acid isolation contained in CNSL in the form of a thick brown extract that has a characteristic dark odor. Anacardic acid was isolated using a maceration method using methanol as a solvent. The results of the

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8

Yang, Wenzhi, Guangjie Liang, Yang Sun, and Zhijin Gong. "Bioactive Secondary Metabolites from Marine Streptomyces griseorubens f8: Isolation, Identification and Biological Activity Assay." Journal of Marine Science and Engineering 9, no. 9 (2021): 978. http://dx.doi.org/10.3390/jmse9090978.

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Marine actinomycetes are a potential source of a wide variety of bioactive natural products. Herein, four cyclic dipeptides, namely, cyclo(L-Val-L-Pro) (compound 1), cyclo(L-Pro-L-Leu) (compound 2), cyclo(L-Pro-L-Tyr) (compound 3) and cyclo(L-Pro-L-Phe) (compound 5), and an N-acetyltyramine (compound 4) were first isolated and identified as products of the marine Streptomyces griseorubens f8. Compounds 3 and 5 exhibit antibacterial activity against Staphylococcus aureus, Klebsiella aerogenes and Proteus vulgaris. The minimum inhibitory concentrations (MICs) against Staphylococcus aureus, Klebs

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9

Veijanen, A., E. Kolehmainen, R. Kauppinen, M. Lahtiperä, and J. Paasivirta. "Methods for the Identification of Tainting Terpenoids and other Compounds from Algae." Water Science and Technology 25, no. 2 (1992): 165–70. http://dx.doi.org/10.2166/wst.1992.0048.

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Off-flavour compounds produced by algae in freshwater ecosystems were studied for their structure using integrated sensory and spectroscopic methods: mass spectrometry (MS), nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR). Both solvent extraction and thermal desorption were used to isolate and to introduce the compounds into gas chromatography/mass spectrometry (GC/MS) and gas chromatography/Fourier transform infrared (GC/FTIR) systems. Ten ng of a terpenoid compound gave a readable IR spectrum. For 1H NMR studies the compounds were collected directly into NMR solvent by

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10

Yoneyama-Hirozane, Mariko, Kohei Deguchi, Takeshi Hirakawa, et al. "Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors." SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, no. 2 (2017): 154–63. http://dx.doi.org/10.1177/2472555217727097.

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Ghrelin O-acyl transferase (GOAT; MBOAT4) catalyzes O-acylation at serine-3 of des-acyl ghrelin. Acyl ghrelin is secreted by stomach X/A-like cells and plays a role in appetite and metabolism. Therefore, GOAT has been expected to be a novel antiobesity target because it is responsible for acyl ghrelin production. Here, we report homogeneous time-resolved fluorescence (HTRF) and enzyme-linked immunosorbent assay (ELISA) methods utilizing human GOAT-expressing microsomes as a novel high-throughput assay system for the discovery of hit compounds and optimization of lead compounds. Hit compounds e

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11

Chira, Kleopatra, Laura Anguellu, Gregory Da Costa, et al. "New C-Glycosidic Ellagitannins Formed upon Oak Wood Toasting, Identification and Sensory Evaluation." Foods 9, no. 10 (2020): 1477. http://dx.doi.org/10.3390/foods9101477.

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In the courses of studies on ellagitannin changes during oak wood toasting, two C-glycosidic ellagitannins were isolated from the french oak wood for the first time. These two compounds exhibited [M−H]− ion peak at m/z 1055.0631 (compound A) and at m/z 1011.0756 (compound B). A compound is named Castacrenin E and is produced by Castacrenin D oxidation. Castacrenin D is a vescalagin with an additional aromating ring to the C-1 through a C-C bond. These compounds are not only found under laboratory conditions but also in commercial oak wood representing different toasting methods and sizes. Thei

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12

Hamid Mohammed Saleh Al-Jubori. "Synthesis And Identification Of from HEMA Schiff Base Derivatives Contains Aldehyde Group For Hexa and Hepta Cyclization." Tikrit Journal of Pure Science 22, no. 1 (2023): 83–94. http://dx.doi.org/10.25130/tjps.v22i1.612.

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In this research the polymer which contains aldehyde group [H1] has been prepared by oxidation [H] using the oxidizing agent (Dess Martin Periodinane), [H1] has been dialyzed by ethanol, Schiff bases[H2,H5andH8] compounds have been prepared through the reaction of compound [H1] with appropriate amines, [H3] compound which contains hydroquinazolin ring has been prepared by the reaction of [H2] compound with 2-amino benzoic acid.[H4]which has been prepared by cyclization reaction of compound [H2] with phthalic anhydride. compounds [H6,H7]were prepared by the reaction of [H5] compound with 2-amin

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13

Mohammed, Abdul Moiz. "UV-Visible Spectrophotometric Method and Validation of Organic Compounds." European Journal of Engineering Research and Science 3, no. 3 (2018): 8. http://dx.doi.org/10.24018/ejers.2018.3.3.622.

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Absorption and emission of radiation by a compound at different wavelengths in visible and ultra violet region forms an analytical tool for identification of organic compounds. Researchers and scientists from different fields of chemistry and life sciences are constantly in search of an alternate ways to analyze the chemical reactions involving organic and inorganic compounds. The UV-Visible spectroscopic technique serves as an important and simple technique in finding concentration of molecules in a solution, identification the functional groups identification of conjugated organic compounds.

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14

Mohammed, Abdul Moiz. "UV-Visible Spectrophotometric Method and Validation of Organic Compounds." European Journal of Engineering and Technology Research 3, no. 3 (2018): 8–11. http://dx.doi.org/10.24018/ejeng.2018.3.3.622.

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Absorption and emission of radiation by a compound at different wavelengths in visible and ultra violet region forms an analytical tool for identification of organic compounds. Researchers and scientists from different fields of chemistry and life sciences are constantly in search of an alternate ways to analyze the chemical reactions involving organic and inorganic compounds. The UV-Visible spectroscopic technique serves as an important and simple technique in finding concentration of molecules in a solution, identification the functional groups identification of conjugated organic compounds.

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15

Sudirman, Sabri, Nurjanah Nurjanah, and Agoes Mardiono Jacoeb. "Identification of Antioxidant Compounds Structure Large-Leafed Mangrove (Bruguiera gymnorrhiza) Fruit." Jurnal Pengolahan Hasil Perikanan Indonesia 19, no. 2 (2016): 94. http://dx.doi.org/10.17844/jphpi.v19i2.13108.

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Antioxidants are compounds that can inhibit or prevent the oxidation of the easily oxidized substrate.<br />One of the plants as a potential source of bioactive compounds and antioxidant activity is large-leafed<br />mangrove (Bruguiera gymnorrhiza). This plant is commonly found in the Pacific region of Southeast Asia,<br />Ryukyu Islands, Micronesia and Polynesia (Samoa) to subtropical regions of Australia and has been used<br />by the society. This study aimed to determine the bioactive compounds structure of large-leafed mangrove<br />has the highest antioxidan

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16

Shahzad Aslam, Muhammad. "PHYTOCHEMISTRY OF AERIAL PARTS OF ARAUCARIA COLUMNARIS." Journal of Applied Pharmacy 6 (2014): 114. http://dx.doi.org/10.21065/19204159.6.114.

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The current article is designed for the extraction of chemical compound. Dichloromethane and methanol were applied to extract the chemical compound so that maximal number of compounds can be drawn out. Thin layer chromatography is applied as Analytical technique for the isolation and identification of the various compounds.

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17

Murini, Tri, Mae Sri Hartati Wahyuningsih, Tri Baskoro Tunggul Satoto, Achmad Fudholi, and Muhammad Hanafi. "ISOLATION AND IDENTIFICATION OF NATURALLY OCCURRING LARVICIDAL COMPOUND ISOLATED FROM ZINGIBER ZERUMBET (L).J.E. SMITH." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 189. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.21703.

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Objective: A naturally occurring larvicidal compound is an alternative to eradication of Aedes aegypti larvae. This compound is toxic to larvae but relatively safe for human. Rhizome of Lempuyang gajah (Zingiber zerumbet (L.) J. E. Smith) has been used traditionally to prevent mosquito bites. An initial study indicated that petroleum ether (PE) soluble fraction of the methanol (MeOH) extract of Z. zerumbet was toxic against larvae lethal concentration (LC50), 67.01±2.35 versus 153.57±4.01 ppm (MeOH ext.). Therefore, this study aimed to isolate and identify the compounds with larvicidal activit

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18

Wang, ShaoPeng, Yu-Hang Zhang, Jing Lu, Weiren Cui, Jerry Hu, and Yu-Dong Cai. "Analysis and Identification of Aptamer-Compound Interactions with a Maximum Relevance Minimum Redundancy and Nearest Neighbor Algorithm." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8351204.

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The development of biochemistry and molecular biology has revealed an increasingly important role of compounds in several biological processes. Like the aptamer-protein interaction, aptamer-compound interaction attracts increasing attention. However, it is time-consuming to select proper aptamers against compounds using traditional methods, such as exponential enrichment. Thus, there is an urgent need to design effective computational methods for searching effective aptamers against compounds. This study attempted to extract important features for aptamer-compound interactions using feature se

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19

Honma, Masaru, Mark Stubbs, Ian Collins, Paul Workman, Wynne Aherne, and Fiona M. Watt. "Identification of Novel Keratinocyte Differentiation Modulating Compounds by High-Throughput Screening." Journal of Biomolecular Screening 11, no. 8 (2006): 977–84. http://dx.doi.org/10.1177/1087057106292556.

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The authors have designed high-throughput screens to identify compounds that promote or inhibit terminal differentiation of primary human epidermal keratinocytes. Eleven known inhibitors of signaling pathways and approximately 4000 compounds of diverse structure were screened using an In-Cell Western system based on immunofluorescent staining of the terminal differentiation marker, involucrin. Staurosporine, a nonspecific protein kinase C inhibitor, and H89, a protein kinase A inhibitor, promoted expression of involucrin. Conversely, U0126, a MEK inhibitor, and SAHA or SBHA, 2 histone deacetyl

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20

Bertram, Raymond, and Jukka Hyönä. "The Role of Hyphens at the Constituent Boundary in Compound Word Identification." Experimental Psychology 60, no. 3 (2013): 157–63. http://dx.doi.org/10.1027/1618-3169/a000183.

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The current eye-movement study investigated whether a salient segmentation cue like the hyphen facilitates the identification of long and short compound words. The study was conducted in Finnish, where compound words exist in great abundance. The results showed that long hyphenated compounds (musiikki-ilta) are identified faster than concatenated ones (yllätystulos), but short hyphenated compounds (ilta-asu) are identified slower than their concatenated counterparts (kesäsää). This pattern of results is explained by the visual acuity principle ( Bertram & Hyönä, 2003 ): A long compound wor

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21

Baburao Patil, Pramod, and Subhash Trimbakrao Kumbhar. "Identification of potential CDK 8 inhibitor from pyrimidine derivatives via In-Silico approach." Journal of Medical pharmaceutical and allied sciences 12, no. 5 (2023): 6038–48. http://dx.doi.org/10.55522/jmpas.v12i5.4784.

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Pyrimidinesare six-membered heterocyclic scaffold present naturally in nucleic acid components and are promising leads for the synthesis of medicinally important compounds. Cyclin-dependent kinases (CDKs) with a serine/threonine catalytic core are important druggable targets for cancer therapy and the binding of regulatory subunits controls them. In the present study series of virtually designed pyrimidine derivatives were screened using molecular docking techniques against the cyclin-dependent kinase-8 (CDK8) as a targeted protein. The density functional theory calculation of compounds having

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Jadoun, Jeries, Ahmad Yazbak, Salwa Rushrush, Amira Rudy, and Hassan Azaizeh. "Identification of a New Antibacterial Sulfur Compound fromRaphanus sativusSeeds." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/9271285.

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Raphanus sativusL. (radish), a member of Brassicaceae, is widely used in traditional medicine in various cultures for treatment of several diseases and disorders associated with microbial infections. The antibacterial activity of the different plant parts has been mainly attributed to several isothiocyanate (ITC) compounds. However, the low correlation between the ITC content and antibacterial activity suggests the involvement of other unknown compounds. The objective of this study was to investigate the antibacterial potential of red radish seeds and identify the active compounds. A crude eth

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23

Ali, Meer Asif, Sugunakar Vuree, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri, and Sanjeev Kumar Singh. "Identification of High-affinity Small Molecules Targeting Gamma Secretase for the Treatment of Alzheimer’s Disease." Current Topics in Medicinal Chemistry 19, no. 13 (2019): 1173–87. http://dx.doi.org/10.2174/1568026619666190617155326.

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Background: Alzheimers Disease (AD) is a neurodegenerative disease which is characterized by the deposition of amyloid plaques in the brain- a concept supported by most of the researchers worldwide. The main component of the plaques being amyloid-beta (Aβ42) results from the sequential cleavage of Amyloid precursor protein (APP) by beta and gamma secretase. This present study intends to inhibit the formation of amyloid plaques by blocking the action of gamma secretase protein with Inhibitors (GSI). Methods: A number of Gamma Secretase Inhibitors (GSI) were targeted to the protein by molecular

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Aini, Kurratul, Elfita Elfita, Hary Widjajanti, Arum Setiawan, and Rian Oktiansyah. "Bioactivity of secondary metabolite of endophytic fungi extract isolated from root of Jambu Mawar (Syzygium jambos (L.) Alston)." International Journal of Secondary Metabolite 12, no. 1 (2025): 16–32. https://doi.org/10.21448/ijsm.1462128.

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This research aims to isolate endophytic fungi from Syzygium jambos and identify their active compounds. Endophytic fungi were isolated from the roots of S. jambos and cultured on Potato Dextrose Agar media. Antibacterial activity using the Kirby–Bauer method was tested on four Gram-positive and Gram-negative bacteria. Molecular identification was carried out on selected isolates to determine the species of endophytic fungi and isolate their active compounds. Column chromatography was used for compound isolation. The pure compounds were then analyzed spectroscopically using 1H-NMR, 13C-NMR, DE

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Kunig, Verena, Marco Potowski, Anne Gohla, and Andreas Brunschweiger. "DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences." Biological Chemistry 399, no. 7 (2018): 691–710. http://dx.doi.org/10.1515/hsz-2018-0119.

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Abstract DNA-encoded compound libraries are a highly attractive technology for the discovery of small molecule protein ligands. These compound collections consist of small molecules covalently connected to individual DNA sequences carrying readable information about the compound structure. DNA-tagging allows for efficient synthesis, handling and interrogation of vast numbers of chemically synthesized, drug-like compounds. They are screened on proteins by an efficient, generic assay based on Darwinian principles of selection. To date, selection of DNA-encoded libraries allowed for the identific

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Wang, Mengyuan, Changliang Yao, Jiayuan Li, et al. "Software Assisted Multi-Tiered Mass Spectrometry Identification of Compounds in Traditional Chinese Medicine: Dalbergia odorifera as an Example." Molecules 27, no. 7 (2022): 2333. http://dx.doi.org/10.3390/molecules27072333.

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The complexity of metabolites in traditional Chinese medicine (TCM) hinders the comprehensive profiling and accurate identification of metabolites. In this study, an approach that integrates enhanced column separation, mass spectrometry post-processing and result verification was proposed and applied in the identification of flavonoids in Dalbergia odorifera. Firstly, column chromatography fractionation, followed by liquid chromatography–tandem mass spectrometry was used for systematic separation and detection. Secondly, a three-level data post-processing method was applied to the identificati

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Meqbil, Yazan J., Hongyu Su, Robert J. Cassell, et al. "Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities." Molecules 26, no. 23 (2021): 7236. http://dx.doi.org/10.3390/molecules26237236.

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The δ-opioid receptor (δOR) holds great potential as a therapeutic target. Yet, clinical drug development, which has focused on δOR agonists that mimic the potent and selective tool compound SNC80 have largely failed. It has increasingly become apparent that the SNC80 scaffold carries with it potent and efficacious β-arrestin recruitment. Here, we screened a relatively small (5120 molecules) physical drug library to identify δOR agonists that underrecruit β-arrestin, as it has been suggested that compounds that efficaciously recruit β-arrestin are proconvulsant. The screen identified a hit com

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28

Prasetiyo, Himawan, Sri Purwaningsih, Iriani Setyaningsih, Mala Nurilmala, Uju Uju, and Kustiyariah Tarman. "Off-odour Identification from Volatile Organic Compounds (VOCs) of Spirulina." BIO Web of Conferences 92 (2024): 02006. http://dx.doi.org/10.1051/bioconf/20249202006.

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Spirulina platensis is a common cyanobacteria microalga with high nutrition and bioactive compound sources. The addition of spirulina in foods and beverages improves nutrition and bioactive compound content. However, certain species of cyanobacteria are known to produce various compounds causing off-odour. This study investigates the chemical profile and volatile organic compounds (VOCs) in spirulina biomass and determine off-odour potency. The spirulina extract was analysed phytochemical qualitatively and GC-MS (Gas Chromatography-Mass Spectrometry). The Spectra mass was compared to the mass

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Manzo, Lawaly Maman, Yijuan Cheng, Ling Yang, et al. "Small-scale screening program for the identification of cytotoxic Oxazolo[5,4-d]pyrimidine derivatives based on Whole Cell Viability Assay." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (2015): 58–65. http://dx.doi.org/10.30750/ijpbr.3.2.6.

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For over last couple of decades, there has been a robust activity aimed towards the discovery of novel anti-cancer therapeutics. An approach to identify starting points for new drug candidates is high throughput screening of compound library collection. In this work, we describe the application of a Tetrazolium-based, 96-well small scale screening assay to screen a mini library of 19 compounds bearing Oxazolo[5,4-d]pyrimidine structures against human umbilical vein endothelial cells. Primary actives identified against HUVEC were retested and the IC50 value compounds were estimated for HUVEC. T

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Huynh, Q. Khai, Sarah J. Wise, Keith A. Koch та ін. "Screening and Identification of a Novel Class of TGF-β Type 1 Receptor Kinase Inhibitor". Journal of Biomolecular Screening 16, № 7 (2011): 724–33. http://dx.doi.org/10.1177/1087057111405846.

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Transforming growth factor β (TGF-β) type I receptor (activin receptor–like kinase 5, ALK5) has been identified as a promising target for fibrotic diseases. To find a novel inhibitor of ALK5, the authors performed a high-throughput screen of a library of 420 000 compounds using dephosphorylated ALK5. From primary hits of 1521 compounds, 555 compounds were confirmed. In total, 124 compounds were then selected for follow-up based on their unique structures and other properties. Repeated concentration–response testing and final interference assays of the above compounds resulted in the discovery

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Violet, Violet. "IDENTIFIKASI PEMANFAATAN TRADISIONAL DAN PENAPISAN SENYAWA FITOKIMIA EKTRAK DAUN BINTANGUR (Callophyllum soulatri Burm F.)." EnviroScienteae 14, no. 1 (2018): 70. http://dx.doi.org/10.20527/es.v14i1.4896.

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Bintangur (Callophylum soulatri) is one type of Family Callophylleae which is widely found in the forests of Borneo. This research attempts to identify the traditional using of Bintangur plant as a medicinal material and get the result of phytochemical compound from Bintangur leaf extract. Identification of the use of Bintangur plants is done using semi-structured interview techniques and literature review. The phytochemical compound preliminary test is carried out qualitatively by color change detection. Bintangur leaves can eliminate the disease vertigo (dizziness) and migraine. The dominant

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Saenz, Jose B., Teresa A. Doggett, and David B. Haslam. "Identification and Characterization of Small Molecules That Inhibit Intracellular Toxin Transport." Infection and Immunity 75, no. 9 (2007): 4552–61. http://dx.doi.org/10.1128/iai.00442-07.

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ABSTRACT Shiga toxin (Stx), cholera toxin (Ctx), and the plant toxin ricin are among several toxins that reach their intracellular destinations via a complex route. Following endocytosis, these toxins travel in a retrograde direction through the endosomal system to the trans-Golgi network, Golgi apparatus, and endoplasmic reticulum (ER). There the toxins are transported across the ER membrane to the cytosol, where they carry out their toxic effects. Transport via the ER from the cell surface to the cytosol is apparently unique to pathogenic toxins, raising the possibility that various stages i

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Nalla, Viswanadh, Aslam Shaikh, Sanket Bapat, et al. "Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents." Royal Society Open Science 5, no. 4 (2018): 171750. http://dx.doi.org/10.1098/rsos.171750.

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A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56–12.5 µg ml −1 . Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 µg ml −1 . Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like propertie

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Manvar, M. N., and T. R. Desai. "ISOLATION AND IDENTIFICATION OF POLYPHENOLIC COMPOUND FROM IPOMOEA AQUATICA FORSK. (CONVOLVULACEAE)." INDIAN DRUGS 53, no. 02 (2016): 19–22. http://dx.doi.org/10.53879/id.53.02.10361.

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Ipomoea aquatica is used in Indian system of medicine and many pharmacological activities have been attributed to it. The preliminary phytochemical screening revealed presence of polyphenolic compounds in it. The hydroalcoholic extracts of leaves of Ipomoea aquatica was studied for isolation of flavonoid by chromatographic method. On the basis of study of physical properties, chemical tests and spectroscopic evaluation (UV, IR, 1HNMR and Mass Spectrometry) the structure of the isolated compound was established. The isolated compound was yellow colored and soluble in methanol, ethanol and dimet

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Song, Xuelei S., Jiaping Zhang, Xun Chen, et al. "Identification of DGAT2 Inhibitors Using Mass Spectrometry." Journal of Biomolecular Screening 21, no. 2 (2015): 117–26. http://dx.doi.org/10.1177/1087057115607463.

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Mass spectrometry offers significant advantages over other detection technologies in the areas of hit finding, hit validation, and medicinal chemistry compound optimization. The foremost obvious advantage is the ability to directly measure enzymatic product formation. In addition, the inherent sensitivity of the liquid chromatography/mass spectrometry (LC/MS) approach allows the execution of enzymatic assays at substrate concentrations typically at or below substrate Km. Another advantage of the LC/MS approach is the ability to assay impure enzyme systems that would otherwise be difficult to p

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Miller, Dustin B., and Stephen R. Piccolo. "CompoundHetVIP: Compound Heterozygous Variant Identification Pipeline." F1000Research 9 (February 10, 2021): 1211. http://dx.doi.org/10.12688/f1000research.26848.2.

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Compound Heterozygous (CH) variant identification requires distinguishing maternally from paternally derived nucleotides, a process that requires numerous computational tools. Using such tools often introduces unforeseen challenges such as installation procedures that are operating-system specific, software dependencies that must be installed, and formatting requirements for input files. To overcome these challenges, we developed Compound Heterozygous Variant Identification Pipeline (CompoundHetVIP), which uses a single Docker image to encapsulate commonly used software tools for file aggregat

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Мilyan, P. М., G. V. Kun, Zh І. Milyan, and J. I. Molnar. "Synthesis and Identification of Pb3TeO6 Compound." Фізика і хімія твердого тіла 16, no. 4 (2015): 658–60. http://dx.doi.org/10.15330/pcss.16.4.658-660.

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In present work, the physico-chemical analysis of the interaction process for PbO:TeO2=3:1 has been carried out. The ternary compound Pb3TeO6 was obtained by solid-phase reaction; this compound was identified by X-ray diffraction and chemical analysis.

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Miller, Dustin B., and Stephen R. Piccolo. "CompoundHetVIP: Compound Heterozygous Variant Identification Pipeline." F1000Research 9 (October 8, 2020): 1211. http://dx.doi.org/10.12688/f1000research.26848.1.

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A compound heterozygous (CH) variant occurs when a person inherits two alternate alleles, one from each parent, and these alleles occur at different positions within the same gene. Therefore, CH variant identification requires distinguishing maternally from paternally derived nucleotides, a process that requires numerous computational tools. Using such tools can be challenging and often introduce unforeseen challenges such as installation procedures that are operating-system specific, software dependencies, and format requirements for input files. To overcome these challenges, we developed Com

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Salemink, P. J. M. "Haemoglobin crystallisation: Identification of the compound." Comparative Haematology International 4, no. 4 (1994): 242–43. http://dx.doi.org/10.1007/bf00185182.

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Abida, Habib. "Identification of compound channel flow parameters." Journal of Hydrology and Hydromechanics 57, no. 3 (2009): 172–81. http://dx.doi.org/10.2478/v10098-009-0016-y.

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Identification of compound channel flow parametersOptimization methods are used to estimate parameters required for routing floods through open compound channels. Besides initial and boundary flow conditions, data required especially include, cross-sectional area (A) of flow and conveyance (K) as functions of flow depth (y) for a representative cross-section of the study reach. Thus, instead of optimizing upon channel's geometric and hydraulic parameters, optimization is performed upon non-physical parameters in assumedA(y) andK(y) relationships. The optimization method selected for this appli

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Gerlich, Michael, and Steffen Neumann. "MetFusion: integration of compound identification strategies." Journal of Mass Spectrometry 48, no. 3 (2013): 291–98. http://dx.doi.org/10.1002/jms.3123.

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Fauzia, Ditya Vega, Dewi Kusrini, and Enny Fachriyah. "Isolation and Testing of Bacteria from Steroid Compounds obtained from Anting-anting Leaf (Acalypha indica L.)." Jurnal Kimia Sains dan Aplikasi 21, no. 2 (2018): 64–69. http://dx.doi.org/10.14710/jksa.21.2.64-69.

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Isolation of steroid compounds from the leaves of the earrings (Acalypha indica L.) and the antibacterial test has been performed. This study aims to obtain information about secondary metabolite compound leaves of Anting-anting, obtaining and identifying steroid isolates from the leaves of Anting-anting and knowing the antibacterial activity of the positive fraction of steroid compounds. The research stages include sample preparation, phytochemical test, isolation, separation, purification of steroid compounds, identification of steroid isolates using LC-MS/MS, and antibacterial test by paper

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Moriev, R., O. Vasylchenko, M. Platonov, O. Grygorenko, K. Volkova, and S. Zozulya. "Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening." Acta Naturae 5, no. 2 (2013): 90–99. http://dx.doi.org/10.32607/20758251-2013-5-2-90-99.

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The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing experimental anti-IGF1R therapeuticals. To this end, targeted compound libraries were produced by virtual screening using molecular modeling and docking strategies, as well as the ligand-based pharmacophore model. High-throughput screening of the resulting compound sets in a biochemical kinase inhibition assay allowed us to identify several nove

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Ito, Hazuki, Kohei Monobe, Saya Okubo, and Shunsuke Aoki. "Identification of Novel Antimicrobial Compounds Targeting Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase Using Dual Hierarchical In Silico Structure-Based Drug Screening." Molecules 29, no. 6 (2024): 1303. http://dx.doi.org/10.3390/molecules29061303.

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The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis (M. tuberculosis) has become a major medical problem. S-adenosyl-L-homocysteine hydrolase (MtSAHH) was selected as the target protein for the identification of novel anti-TB drugs. Dual hierarchical in silico Structure-Based Drug Screening was performed using a 3D compound structure library (with over 150 thousand synthetic chemicals) to identify compounds that bind to MtSAHH’s active site. In vitro experiments were conducted to verify whether the nine compounds selected as new drug candidates exhibi

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Yu, Ruirui, Xiaojian Li, Peng Yi, et al. "Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities." Molecules 28, no. 21 (2023): 7321. http://dx.doi.org/10.3390/molecules28217321.

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This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus

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Majid, Z. A. N. M., L. Rahmawati, and C. Riyani. "Identification of bio-oil chemical compounds from pyrolysis process of oil palm empty fruit bunches." IOP Conference Series: Earth and Environmental Science 1063, no. 1 (2022): 012001. http://dx.doi.org/10.1088/1755-1315/1063/1/012001.

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Abstract Indonesia is the highest CPO producer globally, but CPO production also produces waste. The highest waste in CPO production is empty fruit bunch (EFB) (±58.3%). EFB is biomass waste that has the highest lignocellulose compound. Lignocellulose compound could utilize by conversion with physical, chemical, and biological degradation. Pyrolysis is one of the physical methods to degrade the lignocellulose compound. This research aimed to determine bioactive compounds produced from EFB pyrolysis. The analysis of chemical compound degradation from pyrolysis used gas chromatography and mass s

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Mauf, Ruwa M., and Neam H. Saleem. "PREPARATION, IDENTIFICATION AND STUDY THE BIOLOGICAL ACTIVITY OF NOVEL HETEROCYCLIC COMPOUNDS DERIVED FROM AZO–CHALCONE." Chemical Problems 23, no. 2 (2025): 272–85. https://doi.org/10.32737/2221-8688-2025-2-272-285.

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This work describes the preparation and spectroscopic investigation of new heterocyclic compounds derived from the 4-aminoantipyrene moiety. The compound (R1)3-((1,5-dimethyl-3-oxo-2phenyl-2,3-dihydro-1H-pyrazol-4-yl)diaz-enyl)-4-hydroxybenzaldehyde was prepared by reacting 4aminoantipyrene with 4-Hydroxybenzaldehyde according to the cold condition at (0-5) Celsius. This represents the starting point to create novel azo-chalcone compounds with a new nucleus as the alpha-beta unsaturated group, and the formation of compound (R2-6) via acetophenone derivatives using ethanol as a solvent under a

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Churchill, Molly L., Sarah J. Holdsworth-Carson, Karla J. Cowley, et al. "Using a Quantitative High-Throughput Screening Platform to Identify Molecular Targets and Compounds as Repurposing Candidates for Endometriosis." Biomolecules 13, no. 6 (2023): 965. http://dx.doi.org/10.3390/biom13060965.

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Endometriosis, defined as the growth of hormonally responsive endometrial-like tissue outside of the uterine cavity, is an estrogen-dependent, chronic, pro-inflammatory disease that affects up to 11.4% of women of reproductive age and gender-diverse people with a uterus. At present, there is no long-term cure, and the identification of new therapies that provide a high level of efficacy and favourable long-term safety profiles with rapid clinical access are a priority. In this study, quantitative high-throughput compound screens of 3517 clinically approved compounds were performed on patient-d

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Asmawati, Asmawati. "Identification of inorganic compounds in eggshell as a dental remineralization material." Journal of Dentomaxillofacial Science 2, no. 3 (2017): 168. http://dx.doi.org/10.15562/jdmfs.v2i3.622.

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Objective: Many patients suffer from sensitive teeth after bleaching that can cause demineralization of enamel and widening of dentinal tubules. Hence, researchers are looking for natural ingredients for enamel remineralization material include chicken egg shells because it contain calcium carbonate that can restore lost inorganic compounds. This study aimed to identify inorganic compound in eggshell as dental remineralization agent.Materials and methods:This study was an experimental laboratory with with post test only control group design. The research sample was five maxillary central incis

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Mohammad Adnan Hashem Al-Blesh. "Identification and determination of Phenolic compounds in Brassica L. (Brassicaceae) species grow in Iraq." Tikrit Journal of Pure Science 22, no. 12 (2023): 29–37. http://dx.doi.org/10.25130/tjps.v22i12.928.

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The present search content identification Phenolic compounds and determination type of compound, concentration and its percentage by high performance liquid chromatochraphy (HPLC) and compared chemical compounds for species that identified seven phenolic compounds for nine species Brassica L.(Brassicaceae) collected from mid and north of Iraq, five species wild B.campestris, B.deflexa, B. juncea, B. nigra and B. tournifortii and four species cultivated B.olearaceae var. botrytis, B.olearaceae var. capitata, B.olearaceae var. gongyloides and B.rapa and determined concentration and percentage by

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