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Journal articles on the topic 'Compoundage'

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Published: 4 June 2021
Last updated: 3 February 2022

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1

Attia, Mohamed I., Mohamed N. Aboul-Enein, Aida A. El-Azzouny, Yousreya A. Maklad, and Hazem A. Ghabbour. "Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/357403.

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Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones6a–pare reported. The test compounds6a–pexhibited anticonvulsant activity mainly in the scPTZ screen. Compound6pemerged as the most active surrogate displaying 100% protection at a dose level of 636 μmol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds6a–pwas confirmedviasingle crystal X-ray structure of compound6g.
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2

Mirebeau, I., G. Iancu, M. Hennion, G. Gavoille, and J. Hubsch. "Neutron study of the frustrated spinel compoundMg1+tFe2−2tTitO4(t=0.55)." Physical Review B 54, no. 22 (December 1, 1996): 15928–36. http://dx.doi.org/10.1103/physrevb.54.15928.

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3

Eya'ane Meva, Francois, Timothy John Prior, David John Evans, and Emmanuel Roland Mang. "Crystal structures ofN′-aminopyridine-2-carboximidamide andN′-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide." Acta Crystallographica Section E Crystallographic Communications 73, no. 7 (June 13, 2017): 1021–25. http://dx.doi.org/10.1107/s2056989017008416.

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The crystal structures ofN′-aminopyridine-2-carboximidamide (C6H8N4),1, andN′-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide (C13H13N5),2, are described. The non-H atoms in compound1are nearly planar (r.m.s. deviation from planarity = 0.0108 Å), while2is twisted about the central N—N bond by 17.8 (2)°. Both molecules are linked by intermolecular N—H...N hydrogen-bonding interactions;1forms a two-dimensional hydrogen-bonding network and for2the network is a one-dimensional chain. The bond lengths of these molecules are similar to those in other literature reports of azine and diimine systems.
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4

Yuksek, H., O. Akyildirim, and O. Gursoy Kol. "Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri-{2-methoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl}-Benzene Derivatives." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/517420.

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Nine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR,1H-NMR,13C-NMR and UV spectral data. The synthesized compounds were analyzed for theirin vitropotential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT andα-tocopherol. Compounds4e,5aand5dshowed best activity for iron binding. In addition, the compounds4were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol,tert-butyl alcohol, acetone andN,N-dimethyl formamide). Thus, the half-neutralization potential values and the correspondingpKavalues were determined in all cases.
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5

Iiduka, Hideaki, and Masato Uchida. "Fixed Point Optimization Algorithms for Network Bandwidth Allocation Problems with Compoundable Constraints." IEEE Communications Letters 15, no. 6 (June 2011): 596–98. http://dx.doi.org/10.1109/lcomm.2011.040711.101369.

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6

Kiran, G., T. Maneshwar, Y. Rajeshwar, and M. Sarangapani. "Microwave-Assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activity of Some New Isatin Derivatives." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/192039.

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A series of β-Isatin aldehyde-N,N′-thiocarbohydrazone derivatives were synthesized and assayed for theirin vitroantimicrobial and antioxidant activity. The new compounds were characterized based on spectral (FT-IR, NMR, MS) analyses. All the test compounds possessed a broad spectrum of activity having MIC values rangeing from 12.5 to 400 μg/ml against the tested microorganisms. Among the compounds3e,3jand3nshow highest significant antimicrobial activity. The free radical scavenging effects of the test compounds against stable free radical DPPH (α,α-diphenyl-β-picryl hydrazyl) and H2O2were measured spectrophotometrically. Compounds3j,3n,3l, and3e, respectively, had the most effective antioxidant activity against DPPH and H2O2scavenging activity.
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7

Krug von Nidda, H. A., A. Schütz, M. Heil, B. Elschner, and A. Loidl. "Electron-spin-resonance investigation of the heavy-fermion compoundCe(Cu1−xNix)2Ge2." Physical Review B 57, no. 22 (June 1, 1998): 14344–51. http://dx.doi.org/10.1103/physrevb.57.14344.

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8

Darehkordi, Ali, and Somayeh Ghazi. "Synthesis of a New Class of Tris- and Bis(1,3,4-thiadiazol-2-amine) Methyl and Ethyl Tris- and Bis-2-(2-(2-benzoyl hydrazinyl)-4-oxothiazolidine) Acetate Derivatives." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/857956.

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Hydrazine, carbothioamide derivatives2,3, and4were synthesized by the condensation of 1, 3, 5-tri carbonyl tri chloride, Terephthaloyl dichloride, and 1, 4-dicarbonyl chloride with thiosemicarbazide in presence of pyridine as a solvent. The reaction of compounds2,3, and4with DMAD or DEAD led to the formation of 4-oxothiozolidine derivatives(4b–c),(3a-c), and(2c-d). The treatment of compounds2,3, and4with 1, 4′-diboromoacetophenone resulted in the formation of thiazole derivatives(2g, 3f, 4f). The treatment of compounds2,3, and4with sulfuric led to the formation of 4H-1,2,4-triazole-3-thiol derivatives (2f,3d, and4d). The cyclization of compounds2,3, and4in the presence of 2N NaOH resulted in the formation of compounds2e-4econtaining two or three [1,2,4]triazole rings which are linked to the benzene ring. These compounds are important and useful monomer for synthesis of various dendrimers.
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9

SINGH, R., P. S. MOHARIR, and V. M. MARU. "MUTUAL AND SELF-COMPOUNDING OF CHAOTIC SYSTEMS." International Journal of Bifurcation and Chaos 06, no. 04 (April 1996): 759–67. http://dx.doi.org/10.1142/s0218127496000424.

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The notion of compounding a chaotic system was introduced earlier. It consisted of varying the parameters of the compoundee system in proportion to the variables of the compounder system, resulting in a compound system which has in general higher Lyapunov exponents. Here, the notion is extended to self-compounding of a system with a real-earth example, and mutual compounding of dynamic systems. In the former, the variables in a system perturb its parameters. In the latter, two systems affect the parameters of each other in proportion to their variables. Examples of systems in such compounding relationships are studied. The existence of self-compounding is indicated in the geodynamics of mantle convection. The effect of mutual compounding is studied in terms of Lyapunov exponent variations.
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10

SINGH, R., P. S. MOHARIR, and V. M. MARU. "COMPOUND CHAOS." International Journal of Bifurcation and Chaos 06, no. 02 (February 1996): 383–93. http://dx.doi.org/10.1142/s0218127496000138.

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Compounding is a statistical notion. Essentially, it comprises of regarding the parameters in a particular statistical distribution as random variables with a prescribed distribution. The compound distribution then acquires the parameters of the compounding distribution as its own. As deterministic chaos, in spite of being deterministic, appears like a statistical phenomenon, the notion of compounding can be extended to chaotic systems. It is shown with illustrations that a chaotic system can be compounded by another chaotic system, giving rise to compound chaos which is, in general, “chaoticer”. The concept can also be used to make a periodic system chaotic, thus opening possibilities of “chaoticization”. Examples of compound chaos and chaoticization are given using Lorenz and Rössler systems, including their attractors and limit cycles as “compoundee” and/or “compounder” systems. The conclusions are based on quantitative studies of Lyapunov exponents and correlation dimensions.
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11

Journal, Baghdad Science. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME (2-AMINO-5-THIOL-1, 3, 4-THIADIAZOLE DERIVATIVES." Baghdad Science Journal 4, no. 1 (March 4, 2007): 89–94. http://dx.doi.org/10.21123/bsj.4.1.89-94.

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Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5-(2-Propanylthio)-1,3,4-thiadiazol) and compound F:2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol. All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy. All of those compounds were screened for their anti-microbial activity in vitro. The results show that most of the compounds A, B, C exhibited moderate to good activity against Gram-positive bacteria and the same compound exhibit low to moderate activity on most gram-negative bacteria under study. Finally, compound E and F had little or no effect organism.
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12

Murayama, S., C. Sekine, A. Yokoyanagi, K. Hoshi, and Y. Ōnuki. "Uniaxial Fermi-surface nesting and spin-density-wave transition in the heavy-fermion compoundCe(Ru0.85Rh0.15)2Si2." Physical Review B 56, no. 17 (November 1, 1997): 11092–96. http://dx.doi.org/10.1103/physrevb.56.11092.

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13

Cao, Xiaomin. "An Upper Bound of Large Deviations for Capacities." Mathematical Problems in Engineering 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/516291.

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Up to now, most of the academic researches about the large deviation and risk theory are under the framework of the classical linear expectations. But motivated by problems of model uncertainties in statistics, measures of risk, and superhedging in finance, sublinear expectations are extensively studied. In this paper, we obtain a type of large deviation principle under the sublinear expectation. This result is a new expression of the Gärtner-Ellis theorem under the sublinear expectations which is in the classical theory of large deviations. In addition, we introduce a new process under the sublinear expectations, that is, theG-Poisson process. We give an application of our result and obtain the rate function of the compoundG-Poisson process in the upper bound of large deviations for capacities. The application of our result opens a new field for the research of risk theory in the future.
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14

Syahputra, Gita, Arwansyah Arwansyah, and Wien Kusharyoto. "Molecular Docking and Molecular Dynamics Study of Alcoholic Compounds as Mycobactericidal Agents Using InhA, MabA and PanK as Receptors." ANNALES BOGORIENSES 22, no. 2 (December 31, 2018): 101. http://dx.doi.org/10.14203/ann.bogor.2018.v22.n2.101-115.

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Tuberculosis (TB) infection is one of the primaryinfectious diseases in many developing countries; even there are minor cases in some developed countries. TB infection spread through the air and ismore probable when using improper disinfectant on medical and laboratory equipment which related to TB research. The appropriate disinfectants which are commonly usedin laboratory equipment can reduce the risk of transmission of TB disease. Alcoholic compoundsare one of the common disinfectants with a broad spectrum activity towardsmicrobes,viruses, and fungus. We employed molecular docking and molecular dynamics simulation to support virtual screening and ligand-receptor complex binding observation in searching for an appropriate mycobactericidal agent.Based on the analysis of molecular docking and molecular dynamics, pentadecanol has potency as a mycobactericidal agent with PanK as itsspecific receptor. The Gibbs free energy (∆G) for the interaction of pentadecanol with PanKhas been found to be -5.5 kcal/mol. Molecular dynamics analysis at 300K and 1 atm for 5 ns showed a little change in the confirmation of the binding site, whilepentadecanolwas still being bound by its binding siteon PanK.
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15

Ningrum, Retno, Elly Purwanti, and Sukarsono Sukarsono. "Alkaloid Compound Identification of Rhodomyrtus tomentosa Stem as Biology Instructional Material for Senior High School X Grade." Jurnal Pendidikan Biologi Indonesia 2, no. 3 (February 9, 2017): 231. http://dx.doi.org/10.22219/jpbi.v2i3.3863.

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Rhodomyrtus tomentosais one of herbs which belongs to myrtaceaefamily. This plant possessesalkaloid which is efficacious as anti diarrhea, anti diabetes, anti microbial, and anti malaria, however some alkaloid compoundsare poisonous. Thus,it is necessity to identify the alkaloid compounds contained in the stem of Rhodomyrtus tomentosa which are known the use. Thisresearch aimed to identify the types of alkaloid compoundsin the Rhodomyrtus tomentosa stem and find out its usesas the biology teaching materials in form of LKS (Student Work Sheet). The research was descriptive explorative which was purposed to describe the types of alkaloid compoundsin the Rhodomyrtus tomentosa stem. LC-MS (Liquid Chromatograpgy-Mas Spectroscopy) was employed in this research to analyze the compounds. The research results showed that there were seven types of alkaloid compounds within the Rhodomyrtus tomentosa, namely: maritidine (BM 288 m/z), berberine (BM 336 m/z), ismine (BM 258 m/z), tazettine (BM 332 m/z), lycorine (BM 288 m/z), deoxytazettine (BM 216 m/z), and homolycorine (BM 316 m/z). The results of the research has been used as biology teaching materials in senior high school X grade,The Biodiversity of Indonesia.
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16

Chowdhury, R. Roy, S. Dhara, and B. Bandyopadhyay. "Evidence of ferromagnetism in vanadium substituted layered intermetallic compoundsRE(Co1−xVx)2Si2( RE =Pr and Nd;0≤x≤0.35)." Journal of Magnetism and Magnetic Materials 401 (March 2016): 998–1005. http://dx.doi.org/10.1016/j.jmmm.2015.10.128.

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17

Ávila, Fabricio William, Valdemar Faquin, Yong Yang, Silvio Junio Ramos, Luiz Roberto G. Guilherme, Theodore W. Thannhauser, and Li Li. "Assessment of the Anticancer CompoundsSe-Methylselenocysteine and Glucosinolates in Se-Biofortified Broccoli (Brassica oleracea L. var.italica) Sprouts and Florets." Journal of Agricultural and Food Chemistry 61, no. 26 (June 24, 2013): 6216–23. http://dx.doi.org/10.1021/jf4016834.

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18

Pagano, Bruno, Iolanda Fotticchia, Stefano De Tito, Carlo A. Mattia, Luciano Mayol, Ettore Novellino, Antonio Randazzo, and Concetta Giancola. "Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4." Journal of Nucleic Acids 2010 (2010): 1–7. http://dx.doi.org/10.4061/2010/247137.

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Guanine-rich nucleic acid sequences can adopt G-quadruplex structures stabilized by layers of four Hoogsteen-paired guanine residues. Quadruplex-prone sequences are found in many regions of human genome and in the telomeres of all eukaryotic organisms. Since small molecules that target G-quadruplexes have been found to be effective telomerase inhibitors, the identification of new specific ligands for G-quadruplexes is emerging as a promising approach to develop new anticancer drugs. Distamycin A is known to bind to AT-rich sequences of duplex DNA, but it has recently been shown to interact also with G-quadruplexes. Here, isothermal titration calorimetry (ITC) and NMR techniques have been employed to characterize the interaction between a dicationic derivative of distamycin A (compound1) and the [d(TGGGGT)]4quadruplex. Additionally, to compare the binding behaviour of netropsin and compound1to the same target, a calometric study of the interaction between netropsin and [d(TGGGGT)]4has been performed. Experiments show that netropsin and compound1are able to bind to [d(TGGGGT)]4with good affinity and comparable thermodynamic profiles. In both cases the interactions are entropically driven processes with a small favourable enthalpic contribution. Interestingly, the structural modifications of compound1decrease the affinity of the ligand toward the duplex, enhancing the selectivity.
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Al-Swaidan, Ibrahim A., Adel S. El-Azab, Amer M. Alanazi, and Alaa A. M. Abdel-Aziz. "Synthesis and Conformational Analysis of Sterically Congested (4R)-(−)-1-(2,4,6-Trimethylbenzenesulfonyl)-3-n-butyryl-4-tert-butyl-2-imidazolidinone: X-Ray Crystallography and Semiempirical Calculations." Journal of Chemistry 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/173902.

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The crystal structure of (4R)-(−)-1-(2,4,6-trimethylbenzenesulfonyl)-3-n-butyryl-4-tert-butyl-2-imidazolidinone(3)was determined by single-crystal X-ray diffraction. Compound3crystallizes in triclinic system in space groupP1 (≠1). The crystal data area=10.62165 Å,b=16.5321 Å,c=8.95729 Å,∝=91.1936∘,β=93.8496∘,γ=88.0974∘,V=1568.22 Å3,Z=3,Dcalc=1.253 g/cm3,μCuKα=15.98 cm−1,F000=636.00,T=20.0°C, andR=0.037. The crystal structure confirmed the occurrence of three molecules of3A,3B, and3Cin which then-butyryl moiety adopted thes-transoidconformation. Crystal structure also revealed that the conformation of 2,4,6-trimethylbenzenesulfonyl groups was inanti-position relative totert-butyl group. The crystal packing showed that three molecules of compound3are stacked as a result of intermolecularπ-πinteractions between the phenyl ring of one molecule and the phenyl ring of the other molecule by approaching each other to an interplanar separation of 5.034 Å. Interestingly, these stacked molecules are also connected by intermolecularCH-πinteraction. The conformational analysis of thes-transoid 3A,3B, and3Cwas separately performed by molecular mechanic MM+ force field. Additionally, computational investigation using semiempirical AM1 and PM3 methods was performed to find a correlation between experimental and calculated geometrical parameters. The data obtained suggest that the structural data furnished by the AM1 method is in better agreement with those experimentally determined for the above compound. It has been found that the lowest energetic conformer computed gives approximate correspondence with experimental solid state data.
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Capita, Rosa, Félix Riesco-Peláez, Alicia Alonso-Hernando, and Carlos Alonso-Calleja. "Exposure of Escherichia coli ATCC 12806 to Sublethal Concentrations of Food-Grade Biocides Influences Its Ability To Form Biofilm, Resistance to Antimicrobials, and Ultrastructure." Applied and Environmental Microbiology 80, no. 4 (December 6, 2013): 1268–80. http://dx.doi.org/10.1128/aem.02283-13.

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ABSTRACTEscherichia coliATCC 12806 was exposed to increasing subinhibitory concentrations of three biocides widely used in food industry facilities: trisodium phosphate (TSP), sodium nitrite (SNI), and sodium hypochlorite (SHY). The cultures exhibited an acquired tolerance to biocides (especially to SNI and SHY) after exposure to such compounds.E. coliproduced biofilms (as observed by confocal laser scanning microscopy) on polystyrene microtiter plates. Previous adaptation to SNI or SHY enhanced the formation of biofilms (with an increase in biovolume and surface coverage) both in the absence and in the presence (MIC/2) of such compounds. TSP reduced the ability ofE. colito produce biofilms. The concentration of suspended cells in the culture broth in contact with the polystyrene surfaces did not influence the biofilm structure. The increase in cell surface hydrophobicity (assessed by a test of microbial adhesion to solvents) after contact with SNI or SHY appeared to be associated with a strong capacity to form biofilms. Cultures exposed to biocides displayed a stable reduced susceptibility to a range of antibiotics (mainly aminoglycosides, cephalosporins, and quinolones) compared with cultures that were not exposed. SNI caused the greatest increase in resistances (14 antibiotics [48.3% of the total tested]) compared with TSP (1 antibiotic [3.4%]) and SHY (3 antibiotics [10.3%]). Adaptation to SHY involved changes in cell morphology (as observed by scanning electron microscopy) and ultrastructure (as observed by transmission electron microscopy) which allowed this bacterium to persist in the presence of severe SHY challenges. The findings of the present study suggest that the use of biocides at subinhibitory concentrations could represent a public health risk.
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21

Waghmare, Vaishali, and Hema Hema. "PRECONCEPTION AND PRENATAL DIAGNOSTIC TECHNIQUES ACT 1994 AND ITS MAIN ROLE TO CURB SEX DETERMINATION AND SEX SELECTION." International Journal of Research -GRANTHAALAYAH 4, no. 7 (July 31, 2016): 75–83. http://dx.doi.org/10.29121/granthaalayah.v4.i7.2016.2595.

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India has a male dominated culture where women are treated like a commodity and slave. Our Indian society gives preference only to the Son not to female because of which girls' child is not heartily welcomed and discrimination against girl child still prevails. Sex selective abortion is one of major issue in recent era in relation to violence against women under which the Ultrasonography machine plays an important role of sex detection. Main cause for sex selection are Patriarchal system, Dowry system, only son who can performs the last rites, lineage and inheritance runs through the male line, the Small family norms , PARAYADHAN, easy access to the Medical facilities and Technology for Sex Selective Abortion. Low literacy rate, low socio-economic condition of women etc. Sex selection and sex determination causes violence, impact on equilibrium of nature, Polyandry, Imbalance between Male-Female populations etc Maharashtra was first State to enact Maharashtra regulation of use of PNDT Act in 1987. The PNDT Act was passed in 1994 Hon. Supreme Court passed an Interim judgment in 2001 for more strict implementation of Act based on PIL filed by CEHAT, MASUM and AdvSabu George PNDT Act amended in 2003 to Pre conception and Pre-natal Diagnostic Technique Act (PC-PNDT) Applicable to all Govt/NGO/Private/corporate establishments . Main purpose of Act is to ban the use of sex selection techniques before and after conception and prevent the misuse of prenatal diagnostic techniques for sex selective abortion. Every offence under this Act is cognizable, non-bailable and non-compoundable (Sec 27). Act has made it mandatory to maintain records of every scan done. (Section 29 and Rule 9) Section 5 and Rule 10 (1A).Implementing Authority under the Act is Appropriate Authority (Section 17) has power to search, seize and seal clinics (Section 30). The Act prohibited communication of sex of the foetus by words, signs or in any other manner (Section 5) , advertising sex determination test in any form are liable for punishment (Section 22) .Offence under this Act punishable with imprisonment of years which extend to 5 years and fine up to 10,000 which extend up to 50,000.
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Gu, Hongwei, Jie Tang, Akiyuki Matsushita, Toshifumi Taniguchi, Yoshikazu Tabata, and Yoshihito Miyako. "Spin-density-wave state under pressure in the heavy-fermion compoundCe(Ru0.95Rh0.05)2Si2." Physical Review B 65, no. 2 (December 10, 2001). http://dx.doi.org/10.1103/physrevb.65.024403.

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23

Malhotra, Honey. "Sentencing Policy in Indian Criminal Justice System: An Analysis with Reference to Compoundable Offences." SSRN Electronic Journal, 2021. http://dx.doi.org/10.2139/ssrn.3873358.

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24

Muhaimin, Madyawati Latief, Riski Dwimalida Putri, and Indri Maharini. "Isolasi Dan Karakterisasi Senyawa Aktif Antimalaria Dari Daun Perepat (Sonneratia alba)." Talenta Conference Series: Science and Technology (ST) 2, no. 2 (June 30, 2019). http://dx.doi.org/10.32734/st.v2i2.506.

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Penggunaan tanaman obat tradisional saat ini makin meningkat, seiring dengan meningkatnya harga obat dan efek samping penggunaan obat modern. Provinsi Jambi memiliki potensi besar akan tumbuhan mangrove. Tumbuhan mangrove selain berfungsi sebagai pelindung ekosistem pantai, juga berpotensi dari segi kandungan kimianya. Salah satu jenis tumbuhan mangrove yang banyak dimanfaatkan masyarakat untuk tanaman obat adalah perepat (Sonneratia alba). Hasil pengujian terdahulu terhadap bioaktivitas ekstrak metanol daun tumbuhan perepat (Sonneratia alba) menunjukkan adanya aktivitas antimalaria. Penelitian ini bertujuan untuk mendapatkan senyawa aktif antimalaria dari daun perepat (Sonneratia alba). Untuk itu pada penelitian ini dilakukan fraksinasi ekstrak metanol daun perepat (Sonneratia alba) dengan menggunakan pelarut organik yang berbeda kepolarannya, dilanjutkan dengan tahap isolasi senyawa aktif antimalaria yang dituntun dengan uji bioaktivitas antimalaria menggunakan Plasmodium berghei, senyawa aktif antimalaria dikarakterisasi menggunakan spektroskopi UV-Vis dan FTIR. Hasil penelitian mampu menjawab jenis atau golongan senyawa aktif yang bersifat antimalaria dan sekaligus mengetahui karakteristik senyawa aktif dari daun perepat (Sonneratia alba) sebagai kandidat obat baru antimalaria. Diharapkan kedepannya senyawa yang mempunyai bioaktivitas ini dapat dikembangkan melalui sintesis di laboratorium, serta bisa dimanfaatkan dalam bidang pengobatan modern. The use of traditional medicine is increasingly as the result of the side effect and the high prices of modern medicine. Jambi province has a huge potency from its mangrove. Mangrove is not only functioned to protect the coastal environment, but it also has a potency from its chemical components. Perapat(Sonneratia alba)is a species of mangrove and the leaves are widely used as traditional medicine.The preliminary study showed the methanol extract of Perepat leaves has potent bioactivity as antimalaria. The aim of this research was to isolate the active compound that has a bioactivity as antimalaria from Perepat leaves (Sonneratia alba) using different organic solvent polarity, followed with the isolation of antimalaria active compoundand it was confirmed by in vivo antimalaria activity using Plasmodium berghei. The obtained potent antimalaria compound was characterized using UV-Vis and FT-IR. The obtained result confirmed the group of potent anti-malaria compound and its characteristic as a new candidate of antimalaria drug. Also, it is expected that in the future a potent antimalaria compound can be developed through synthesis in the laboratory and can be used in the field of modern medicine.
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