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Journal articles on the topic 'Compression Tablet'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Astriani Nurjanah and Neni Nurlelah. "Formulation and Physical Evaluation of CTM Tablets by Direct Compression Method: A Systematic Literature Review." Eureka Herba Indonesia 4, no. 4 (2023): 305–9. http://dx.doi.org/10.37275/ehi.v4i4.88.

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The direct compression method is one of the well-known formulation approaches in tablet manufacture. In this method, the active ingredients and additives of the formulation are mixed together and then compressed into tablets using a special device such as a compression machine. This study is a systematic review that aims to explore the formulation and physical evaluation of CTM tablets by direct compression method. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the formulation and physical e

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2

Rajiv Kumar, Kiranjeet Kaur Batth, Jaspreet Kaur, Jaspreet Kaur, Parminder Nain, and R. K. Dhawan. "A most convenient and patient compliance dosage form- Tablet." Journal of Biomedical and Pharmaceutical Research 9, no. 6 (2020): 13–19. http://dx.doi.org/10.32553/jbpr.v9i6.815.

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Tablet is defined as solid pharmaceutical dosage form containing drug substance generally with suitable diluents and prepared by either compression which is given as a single unit and are known as solid unit dosage form. Tablets remain popular as a dosage form because of the advantages afforded, both to the manufacturer (e.g. simplicity and economy of the preparation, stability, and convenience in packing, shipping and dispensing) and the patient. The excipients include diluents, Binders and adhesives, disintegrates, etc. Tablets vary in shape and differ greatly in size and weight depending on

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3

Balcha Balla, Tamrat, Nisha MaryJoseph, and Anteneh Belete. "In Vitro Evaluation of Native Taro Boloso-I Starch as a Disintegrant in Tablet Formulations." Advances in Materials Science and Engineering 2021 (December 24, 2021): 1–10. http://dx.doi.org/10.1155/2021/7576730.

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Introduction. In drug delivery, solid dosage forms, of which tablet is the commonest, are still the leading preferences. An area of research focus in tablet drug delivery is the search for tablet excipients. This study was aimed at evaluating and optimizing native Taro Boloso-I starch as a tablet disintegrant. Methods. The response surface method with central composite design (CCD-RSM) was used for the analysis and optimization of the concentration of native Taro Boloso-I starch and compression force. Wet granulation method was used for the preparation of paracetamol tablets. The response vari

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4

Suresh, Kumar Paramasivam, Batlanki Priyanka, Vemula Sindhu, Patro Varanasi Jagannath, Kumar T. Praveen, and Sulthana Syed Yasmin. "Formulation and in vitro characterization of tapentadol HCL as immediate release tablets." GSC Biological and Pharmaceutical Sciences 4, no. 3 (2018): 042–48. https://doi.org/10.5281/zenodo.4305776.

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The aim of the present study is to develop and evaluate the immediate release tablet of tapentadol by direct compression method. The superdisintegrant explotab, solutab and polyplasdoneXL were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F2 exhibits highest dissolution using explotab showed faster dru

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5

Luo, Qiuhua, Qianying Zhang, and Puxiu Wang. "Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression." Pharmaceutics 14, no. 8 (2022): 1741. http://dx.doi.org/10.3390/pharmaceutics14081741.

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Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) was used as a model drug to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors, followed by D-optimal mixture experimental design to optimize the final parameters. The type and amount of lactose monohydrate (SuperTab®14SD, 19.53–26.91%), microcrystalline cellulose (MCC PH102, 32.86–43.31%), pre-gelatinized starch (Starch-1500, 10.96–15.91%), and magnesium stearate (0.7%) were determined according to the compressive work, stress

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6

Akhtar, Sabina, and Pulak Dev. "FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 61. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20958.

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Objective: The overall objective of the present study was to formulate the chewable multivitamin tablet prepared by direct compression method.Methods: The excipient used in this study are mannitol, sucrose, starch, talc, magnesium stearate, vanilla powder for the effective formulation. As it is multivitamin, ascorbic acid, riboflavin, nicotinamide, thiamine HCL are used and evaluated for precompression parameter. The chewable tablets were better presented using sweetener sucrose and vanilla powder as a flavouring agent. The formulated tablet was evaluated for post compression parameter. The ch

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7

Arunima, Das*1 Sayantika Chaudhuri2. "Investigating Granule Compression Dynamics: A Heckel Plot Approach to Optimize Crushing Strength in Tablet Formulations." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 286–90. https://doi.org/10.5281/zenodo.14807858.

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Tablet manufacturing is a pivotal process in the pharmaceutical industry, where granule behaviour under compression significantly influences the mechanical properties and therapeutic efficacy of the final product. This study investigates the deformation behaviour of granules, the role of porosity, and the application of the Heckel equation in understanding tablet properties. Using hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), lactose, and two different binders—starch (F1) and PVP K30 (F2)—tablets were prepared via the wet granulation method and compressed at various f

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Siti Mursidatur Rohmah, Dewi Rashati,. "UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 1, no. 1 (2021): 13–20. http://dx.doi.org/10.53864/jifakfar.v1i1.6.

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The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tabl

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9

Sunayana S, Ruchi, Gowda Dv, Vishal Gupta N, Praveen Sivadasu, and Manjunath M. "FORMULATION DEVELOPMENT AND EVALUATION OF ALMOND GUM BASED SUSTAINED RELEASE MATRIX TABLET OF INDOMETHACIN." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (2018): 166. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.26301.

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Objective: The aspiration of the current research involves employing various concentrations of polymer and filler to develop indomethacin sustained release (SR) matrix tablets. The objective of this research work is to reduce dosing frequency thereby increasing patients compliance and enhanced therapeutic activity.Methods: Polymers such as Almond gum (AG), polyvinylpyrrolidone (PVP), and starch at different concentrations were used for formulating SR polymeric matrix tablets. Evaluation of pre-compression and post-compression parameters was done for both granules and formulated tablets.Results

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10

Hasson, Kahtan J. "Comparative study for the dissolution of Isosorbide dinitrate tablets in commercial products." Al Mustansiriyah Journal of Pharmaceutical Sciences 9, no. 1 (2011): 7–12. http://dx.doi.org/10.32947/ajps.v9i1.267.

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Isosorbide dinitrate is prepared as a solid dosage forms, and found in the market as a sublingual tablet or conventional tablet of 10mg for oral administration which is subjected to the dissolution study.In this present work, different commercial products of Isosorbide dinitrate tablets were subjected to dissolution test according to USP method which includes an HPLC determination. The dissolution profiles of three commercial products of isosorbide dintrate tablets and preformulated product were evaluated by comparing with that of reference standard (European product. Actavis Co.) .Due to low

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Ramesh, Pastham, Reddy Sunil, and Allenki Venkatesam. "Design and In-vitro Evaluation of Enteric Coated Pulsatile Drug Delivery System of Zileuton Tablets." Pharmaceutical and Chemical Journal 4, no. 4 (2017): 57–65. https://doi.org/10.5281/zenodo.13785001.

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In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopo

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12

Gavali, Prashant* Gangurde Gayatri Dhum Manohar Sonawane Mitesh. "Development And Characterization of Bilayered Tablet of Paracetamol & Diclofenac Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1588–94. https://doi.org/10.5281/zenodo.15041971.

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By defining a bilayer tablet with a immediate release layer of paracetamol and a sustain release layer of diclofenac sodium, and by evaluating  their pre-compression and post-compression parameters, the primary goal of this research project is to create a steady detailing of a NASAID. A bilayer tablet consists of a moment layer for support discharge of diclofenac sodium and a layer for moment discharge of paracetamol. At that point, the bilayer tablet is planned by weighing all necessary fixings and following the coordinated compression strategy.  Using a USP disintegration device, t

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13

Guštafík, Adam, Kristian Jezsó, Karolína Vaľková, Oliver Macho, and Peter Peciar. "Effect of Moisture of Pharmaceutical Material MCC Avicel PH102 and Tablet Diameter on the Compression Process and Tablet Strength." Strojnícky časopis - Journal of Mechanical Engineering 72, no. 1 (2022): 49–54. http://dx.doi.org/10.2478/scjme-2022-0005.

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Abstract This paper focuses on the effect of moisture of powder material on the process of tablet compression and on tablet mechanical strength. The powder used in the experiments was Avicel PH102 microcrystalline cellulose, as it is the most widely used excipient in direct tablet compression. The compression process is described using the Heckel equation and the strength of the tablets was determined using a Brazilian test. To introduce the reader to the issue, the first part of the paper is devoted to a theoretical introduction. The second part of the work is devoted to the description of ex

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14

Iswandi, Iswandi, and Pudiastuti Pudiastuti. "Variasi Jenis Diluent terhadap Mutu Fisik Tablet Temu Putih (Curcuma zedoaria) menggunakan Metode Cetak Langsung." AFAMEDIS 4, no. 2 (2023): 78–83. http://dx.doi.org/10.61609/afamedis.v4i2.83.

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White Tumeric (Curcuma zedoaria) is a plant that contains curcuminoid compounds and essential oils on its rhizomes, which are helpful as an anticancer. This study aims to determine which filling material (diluent) is good as a filler for white meeting tablets (Curcuma zedoaria). Tablets are made using the direct printing method with the types of fillers (diluent) used are ludipress, starch 1500, and Spray Dried Lactose. The resulting tablets were carried out still angle and flow properties tests, compression index tests, weight uniformity tests, size uniformity tests, tablet hardness tests, ta

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15

Kotsur, Ju M., Ju M. Ladytko, I. A. Narkevich, and E. V. Flisyuk. "Prediction of the composition of prolonged release tablets based on 4,4'-(propandiamido) sodium dibenzoate using the SeDeM method." Drug development & registration 10, no. 4 (2021): 54–62. http://dx.doi.org/10.33380/2305-2066-2021-10-4(1)-54-62.

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Introduction. Direct compression technology is one of the most common tablet technologies. As known, many active pharmaceutical ingredients are not suitable for this technology without the addition of special excipients. A useful tool for determining the suitability of powdered materials for direct compression technology is the Sediment Delivery Model (SeDeM) method, based on the concept of Quality by Design. The presented method allows not only to assess the suitability of a material for direct compression, but also helps to predict the composition of a solid dosage form in the form of a tabl

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16

Anusha Gaddameedi and Anand Kumar Yegnoor. "Formulation and in vitro evaluation of compression coated mebeverine HCl tablets for colon targeting." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 019–29. http://dx.doi.org/10.30574/gscbps.2023.23.3.0210.

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The aim of the study was to develop colon targeted compression coated Mebeverine HCl (MEB) tablets using pH dependent, swellable and rupturable polymers for effective treatment of irritable bowel syndrome (IBS). The MEB loaded core tablets were prepared by direct compression method using CCM and CP as super disintegrating agents at different concentrations and evaluated for pre compression and post compression parameters. The optimized core tablets were further used to fabricate compression coated tablets using different ratios of Eudragit L100, Eudragit S100 as pH- dependent polymers, Keltone

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17

Anusha, Gaddameedi, and Kumar Yegnoor Anand. "Formulation and in vitro evaluation of compression coated mebeverine HCl tablets for colon targeting." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 019–29. https://doi.org/10.5281/zenodo.8260293.

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The aim of the study was to develop colon targeted compression coated Mebeverine HCl (MEB) tablets using pH dependent, swellable and rupturable polymers for effective treatment of irritable bowel syndrome (IBS). The MEB loaded core tablets were prepared by direct compression method using CCM and CP as super disintegrating agents at different concentrations and evaluated for pre compression and post compression parameters. The optimized core tablets were further used to fabricate compression coated tablets using different ratios of Eudragit L100, Eudragit S100 as pH- dependent polymers, Keltone

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18

Sachan, Anupam Kumar. "Comparative Study of Natural and Synthetic Superdisintegrants in Orodispersible Metformin Tablet." Asian Journal of Pharmaceutical Research and Development 7, no. 3 (2019): 46–53. http://dx.doi.org/10.22270/ajprd.v7i3.509.

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Objective: The main objective of this study is comparative study of natural and synthetic superdisintegrants in orodispersible Metformin tablet by using direct compression method and wet granulation method. Method: Orodispersible Metformin tablet were prepared by wet granulation method and direct compression method by using different synthetic and natural superdisintegrants. Orodispersible tablets (ODTs) have received more interest in the pharmaceutical industry for their easy to use and self medication. ODTs overcome the problem of dysphagia (difficulty in swallowing) in the all group a

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19

Vaishnavi, Raskar* Tanaya Wackchaure. "Formulation And Evaluation of Antitussive Tablet of Ginger." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1071–76. https://doi.org/10.5281/zenodo.15605468.

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Zingiber officinal, species of the ginger family Zingiberaceae has a long history of medicinal use for more than 2000 years as one of the most versatile medicinal plants having a wide spectrum of biological activity and a common condiment for various foods and beverages. Currently, there is a renewed interest in ginger, and several scientific investigations aimed at isolation, identification of active constituents , scientific verification of its pharmacological actions for treatment of several diseases and conditions. Solid Dosage Forms are popular as case of administration, accurate dosage,

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20

Begam, Farghana, Rajalakshmi A. N, and Padmapriya S. "FORMULATION AND EVALUATION OF THYROID HORMONE(T3) IMMEDIATE RELEASE TABLETS." International journal of multidisciplinary advanced scientific research and innovation 1, no. 10 (2021): 383–88. http://dx.doi.org/10.53633/ijmasri.2021.1.10.021.

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The study was aimed to formulate and evaluate Thyroid hormone (T3) immediate release tablets of a model Reference Listed Drug (RLD). The objective was to develop a cost effective immediate release tablet formulation and to optimize the formula in product development same that of the reference product. The ingredients used were API (thyroid hormone), lactose monohydrate (diluent), acacia (binder), maize starch (disintegrant), sodium chloride (alkalinizing agent) and magnesium stearate (lubricant). The concentration of maize starch and magnesium stearate were altered to reach the objective. Tota

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21

Rohith, Mr N. P. Ajay, Ms B. A. Binisha Das Ms. B. A. Binisha Das, Ms J. S. Jothisha Ms. J. S. Jothisha, Ms J. Prathesha Ms. J. Prathesha, and Ms M. Dharshini Ms. M. Dharshini. "Development of Formulation and Evaluation of Fexofenadine Hydrochloride Uncoated Tablet by Wet Granulation Method." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1646–54. https://doi.org/10.35629/4494-100316461654.

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The development and evaluation of Fexofenadine hydrochloride(HCl) uncoated tablets were aimed at formulating and effective and patient compliant dosage form for the treatment of allergic rhinitis and uticaria. The formulation process included the selection of suitable binder and lubricant to ensure uniformity and stability. The tablets were prepared using direct compression followed by evaluation of their physiochemical properties including weight variation test, hardness, friability, disintegration time and dissolution test.Result demonstrated that the developed Fexofenadine HCl uncoated tabl

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Badawi, Aliaa A., Mahmoud M. Hegazy, Dina Louis, and Mohammed A. Eldegwy. "Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up." Acta Pharmaceutica 67, no. 4 (2017): 511–25. http://dx.doi.org/10.1515/acph-2017-0033.

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AbstractL-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were suggested (Aerosil 200, Aerosil R972, talc) to reduce stickiness at three concentrations (1, 3 and 5 %), and three fillers (mannitol, Avicel PH 101, Dibasic calcium phosphate) were chosen to prepare 27 formulations. Micromeritic properties of formulations were studied, and tablets were prepared by wet granulation. Absence of picking, s

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23

Agarkar, Sonali. "FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASED GLICLAZIDE TABLETS WITH THE DIFFERENT HYDROPHILIC POLYMER BY USING DIRECT COMPRESSION." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 05, no. 12 (2021): 1–18. http://dx.doi.org/10.55041/ijsrem11083.

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To effectively manage the diabetic mellitus type-II hyperglycemic problem, Gliclazide tablet is the sustained- release tablet that has been designed and fabricated for years. This research evaluated the effects of different grades of hydrophilic polymers in sustained release of Gliclazide tablets made with direct compression technique. HPC GF GRADE, HPMC K4M, and PARTECK® SRP 80 were used as the polymer, Avicel pH 101 (MCC) was used as the highly compressible diluent and Starch 1500 was used as insoluble tablet filler. Aerosil 300 and Magnesium Stearate was used as a Glidant and lubricant for

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Franc, Aleš, Slavomir Kurhajec, Sylvie Pavloková, Dana Sabadková, and Jan Muselík. "Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits." Acta Pharmaceutica 67, no. 2 (2017): 187–202. http://dx.doi.org/10.1515/acph-2017-0019.

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AbstractThe aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel®PH 101 and Avicel®PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel®PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets eve

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Swapnali, Kawade. "Formulation and Evaluation of Nutraceutical Tablet Using Clove Drugs by Wet Granulation Method." International Journal for Research in Applied Science and Engineering Technology 9, no. 12 (2021): 1626–40. http://dx.doi.org/10.22214/ijraset.2021.39517.

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Abstract: The objective of present study was to formulate and evaluate the nutraceutical tablets with different combination of herbal drugs. Material and Method: The nutraceutical tablet containing lactose and mannitol as diluent and containing natural drugs like clove and cinnamon which was prepared by direct compression method. The compressed formulations were subject to several evaluation parameters like appearance, thickness, weight variation, hardness and friability. Results: The results of all evaluation parameters of nutraceutical tablet were within the acceptable limit. Pre-compression

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Kim, Joo-Eun, and Young-Joon Park. "QbD Consideration for Developing a Double-Layered Tablet into a Single-Layered Tablet with Telmisartan and Amlodipine." Pharmaceutics 14, no. 2 (2022): 377. http://dx.doi.org/10.3390/pharmaceutics14020377.

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The aim of this study was to develop a single-layered version of commercially available Twynstar® (Telmisartan + Amlodipine) double-layered tablets to improve the dosing convenience. A quality-by-design approach was applied to develop the single-layered version. To evaluate the range and cause of risks for a single-layered tablet in the formulation design research, we used the tools of the risk assessment, initial risk assessment of preliminary hazard analysis and main risk assessment of failure mode and effect analysis to determine the parameters affecting formulation, drug dissolution, and i

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Rane, Devendra Revanand, Hemant Narhar Gulve, Vikas Vasant Patil, Vinod Madhaorao Thakare, and Vijay Raghunath Patil. "Formulation and evaluation of fast dissolving tablet of albendazole." International Current Pharmaceutical Journal 1, no. 10 (2012): 311–16. http://dx.doi.org/10.3329/icpj.v1i10.11848.

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Albendazole is broad spectrum anthelmintic use against many helminths. It is used for treatment of Threadworm, Hookworm, and Tapeworm. It has low bioavailability due to its first pass metabolism. In the present work, fast dissolving tablet of Albendazole was design with a view to and provide a quick onset of action. The main objective of the study was to formulate fast dissolving tablets of Albendazole to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving tablets prepared by direct compression and using super disintegrants in different conc

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Parfati, Nani, Karina Citra Rani, and Meilany Meilany. "THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (CROSPOVIDONE-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 318. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.23010.

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Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the for

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Kumar, Lavi, Bhupendra Singh, Geetanjali Saini, et al. "Design, Formulation, Optimization and In-vitro Evaluation of Colon-targeted Tablet Utilizing Polymer Isolated from Artocarpus heterophyllus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1112–19. http://dx.doi.org/10.25258/ijddt.12.3.31.

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Objective: The objective of the present study is to formulate, optimize, and evaluate the colon-targeted oral Tablet by utilizing the polymer obtained from Artocarpus heterophyllus. Ibuprofen was used as a model drug in the study. Methods: The Polymer was extracted from the fresh fruits of Artocarpus heterophyllus and subjected to identification and characterization. The formula of the Tablet was optimized using 3 factors 3 levels Box-Behnken design (Design Expert Software). The colon-targeted Tablets were then formulated and coated with pH-dependent polymer to avoid release in the upper gastr

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Nnamani, N. D., I. S. Okafor, and O. N. Ume. "Evaluating the effect of spherical crystallization of acetylsalicylic acid crystal and crystal agglomeration of Manihotesculenta starch on direct compression tablet properties." Bayero Journal of Pure and Applied Sciences 13, no. 2 (2021): 29–35. http://dx.doi.org/10.4314/bajopas.v13i2.4.

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Spherical crystallization and crystal agglomeration have been used to optimize compact crystals and functional properties of powders. The aim of this work is to evaluate the effect of spherical crystallization of acetylsalicylic acid crystals and crystal agglomeration of Manihotesculenta starch on direct compression tablet. Typical spherical crystallization using three solvent system of water–ethanol-carbon tetrachloride was used to produce spherical acetylsalicylic acid. Salting-out agglomeration of gelling in water and salting in ethanol was used to produce starch-xerogel from Manihotesculen

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Hilya Nur Imtihani, Jade Rhea Almira Arif, and Galuh Tarita Kasih Putri. "PENGARUH VARIASI PRIMOGEL SEBAGAI DISINTEGRAN TERHADAP MUTU FISIK TABLET KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DARI CO-PROCESSED EXCIPIENT." Jurnal Kesehatan Islam : Islamic Health Journal 13, no. 1 (2024): 14–20. http://dx.doi.org/10.33474/jki.v13i1.21721.

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Abstract. Mud crab shells contain chitin which can be converted into chitosan. Co-processed excipient or combining two or more excipient ingredients can increase the compressibility, compactibility of tablets. This research aims to formulate the active ingredient chitosan which is synthesized from mangrove crab (Scylla serrata) shells and then make chitosan tablets with a co-processed excipient consisting of two variations of primogel. The difference in formula, namely F1 (primogel 4%) and F2 (primogel 8%) was then seen as to its effect on the physical quality of the tablet. The tablet printin

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Qureshi, Aminabi, Umaima Shaikh, Mehrunnisa Shaikh, Wafa Parkar, Maria Lal, and Mirza Salman Baig. "Solid Dispersion Incorporated Indomethacin Oro- Dispersible Tablet." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7580–88. https://doi.org/10.37285/ijpsn.2024.17.5.4.

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Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers. Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions. Result: All pre- and post-compressional parameters were found within pre-determined lim

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Ganesh, U. Chavan* Payal V. Suradkar Trupti D. Hudekar. "A Comprehensive Review On: Tablet." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 794–805. https://doi.org/10.5281/zenodo.13936009.

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Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet. Medicines are not just a science but an art, involving understanding the processes of life. Pharmaceutical oral solid dosage forms have been widely used for decades due to their convenience and suitability for systemic effects. Tablets, made from powders, granules, pellets, or film-coated units, are the most popular dosage form, accounting for 70% of ethical pharmaceutical preparations. They can be prepared using compression or moulding method

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Ganesh, U. Chavan1* Payal V. Suradkar2 Trupti D. Hudekar2. "A Comprehensive Review On: Tablet." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 794–805. https://doi.org/10.5281/zenodo.13963865.

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Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet. Medicines are not just a science but an art, involving understanding the processes of life. Pharmaceutical oral solid dosage forms have been widely used for decades due to their convenience and suitability for systemic effects. Tablets, made from powders, granules, pellets, or film-coated units, are the most popular dosage form, accounting for 70% of ethical pharmaceutical preparations. They can be prepared using compression or moulding method

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Sanket, Khedkar* Dr. Nikita Parage. "Comprehensive Insight into Tablet Formulations: Types, Manufacturing Techniques, and Evaluation Standards." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1141–53. https://doi.org/10.5281/zenodo.15355737.

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  Tablets are a commonly used solid dosage form prepared through compression methods. They are essential for treating various medical conditions and are preferred by patients due to their convenience compared to other dosage forms. Tablets are cost-effective, easy to administer, and ensure precise dose delivery for therapeutic purposes. Table manufacturing techniques include wet granulation, dry granulation, and direct compression. These involve mixing active pharmaceutical ingredients (API) with excipients, blending, granulating, or direct compression using a tablet punching machine. Inn

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Hussein, Ahmed A. "Using of Sintering and Microwave Techniques to Control the Release of Trifluoperazine HCl fromWax Matrix." Al Mustansiriyah Journal of Pharmaceutical Sciences 7, no. 1 (2010): 43–56. http://dx.doi.org/10.32947/ajps.v7i1.316.

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The very water soluble drug, trifluoperazine HCl was prepared as sustained release carnauba wax matrix tablets using direct compression method.Different amounts of carnauba wax as matrix substance was used to show its effect on drug release. Also sintering as new technique was used in order toretard the drug release from carnauba wax matrix tablets; the granules before compression or the tablets after compression were exposed to 90°C or 120°C for 3 or 5 minutes. Microwave is another technique which was used to prolong the drug release from carnauba wax matrix tablets. The granules before compr

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Yazdi, Zahra Rezaie, Mark C. Leaper, and Danish J. Malik. "The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release." Processes 11, no. 11 (2023): 3146. http://dx.doi.org/10.3390/pr11113146.

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This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage form containing a salmonella-specific Myoviridae phage, Felix O1, encapsulated in spray-dried trehalose/Eudragit microparticles. The spray-dried powder was further formulated by combining the spray-dried microparticles with magnesium stearate to facilitate the fabrication of tablets using direct compression. The paper presents a comprehensive evaluation of the tablets wi

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M., Asha Rani 1. *. H.N. Chaya 1. T. Chakraborty 2. Dr. C.S.R. Lakshmi 1. Dr. L.V.G. Nargund 1. "DESIGN AND DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS OF QUETIAPINE FUMARATE BY DIRECT COMPRESSION METHOD." Journal of Pharma Research 7, no. 7 (2018): 175–78. https://doi.org/10.5281/zenodo.1322962.

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<strong><em>ABSTRACT</em></strong> <strong><em>Q</em></strong><em>uetiapine Fumarate is a (atypical antipsychotic) psychotropic agent that belongs to the dibenzothiazepine class used for the treatment for schizophrenia. Patients, particularly pediatric and geriatric patients, have difficulty in swallowing solid dosage forms thus orodispersible drug delivery system have the combined advantages of both liquid and conventional tablet formulation and offer added advantage over both the traditional dosage form. In the present work orodispersible tablets of Quetiapine Fumarate were prepared by direc

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Olorunsola, Emmanuel O., Grace A. Akpan, and Michael U. Adikwu. "Evaluation of Chitosan-Microcrystalline Cellulose Blends as Direct Compression Excipients." Journal of Drug Delivery 2017 (December 19, 2017): 1–8. http://dx.doi.org/10.1155/2017/8563858.

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This study was aimed at evaluating chitosan-microcrystalline cellulose blends as direct compression excipients. Crab shell chitosan, α-lactose monohydrate, and microcrystalline cellulose powders were characterized. Blends of the microcrystalline cellulose and chitosan in ratios 9 : 1, 4 : 1, 2 : 1, and 1 : 1 as direct compression excipients were made to constitute 60% of metronidazole tablets. Similar tablets containing blends of the microcrystalline cellulose and α-lactose monohydrate as well as those containing pure microcrystalline cellulose were also produced. The compact density, tensile

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Khan, MD Abdul Aali, M. S. Sudheesh, and Rajesh Singh Pawar. "Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 42–46. http://dx.doi.org/10.22270/jddt.v12i6-s.5696.

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The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to f

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Peddapatla, Raghu V. G., Conor Slevin, Gerard Sheridan, et al. "Modelling the Compaction Step of a Platform Direct Compression Process." Pharmaceutics 14, no. 4 (2022): 695. http://dx.doi.org/10.3390/pharmaceutics14040695.

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The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs. However, it is challenging to extrapolate compaction settings for direct compression formulations between tablet press models during scale-up and transfer from R&D to commercial production. The aim of this study was to develop statistical process models to predict tablet tensile strength, porosity and disintegration time from compaction parameters (pre-compression and main compression force, and press speed), for three formulations

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Gönüllü, Ü., P. Gürpınar, and M. Üner. "Double-layer Tablets of Lornoxicam: Validation of Quantification Method, In vitro Dissolution and Kinetic Modelling." Tropical Journal of Pharmaceutical Research 14, no. 9 (2015): 1659–66. http://dx.doi.org/10.4314/tjpr.v14i9.16.

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Purpose: To formulate double-layer tablets of lornoxicam (LRX) prepared by direct compression method and evaluate their physical and drug release characteristics.Methods: The outer layer of tablets, composed of microcrystalline cellulose (MCC), starch and lactose, incorporated tan initial or prompt dose of the drug (4 mg) for immediate release. Hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP K90) and carbomer, in varying concentrations, were used to prepare the tablet cores for sustained drug delivery. Weight variation, dimensions, hardness, tensile strength, friability and dis

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Kumar, Damit, Amit Sharma, and Rajiv Garg. "FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF LOSARTAN POTASSIUM." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 54–66. http://dx.doi.org/10.22270/ajprd.v6i4.386.

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The objective of the current study was to develop and optimize a sublingual tablet of Losartan potassium, which is an effective drug in the treatment of hypertension. Owing to number of advantages dissociated with the quick onset of action and it by passes the liver. Sublingual tablets offer effective and easier way for management of Hypertension. The basic approach used in development of Sublingual tablet was the use of super disintegrants by direct compression method. Oral mucosal drug delivery is one of the promising method of systemic drug delivery which offers several advantages. The lite

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P, Pavazhaviji, and Rajalakshmi A. N. "FIXED-DOSE COMBINATION DRUGS AS TABLET IN TABLET: A REVIEW." International journal of multidisciplinary advanced scientific research and innovation 1, no. 9 (2021): 169–77. http://dx.doi.org/10.53633/ijmasri.2021.1.9.02.

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The Pharmaceutical industry has become more interested in developing fixed-dose combinations (FDCs) in recent years. FDCs have been used successfully in a variety of clinical areas, including diabetes, HIV/AIDS,and cardiovascular diseases etc. FDCs are intended to extend the product life cycle and enhance patient compliance by decreasing cost. Active Pharmaceutical ingredients are chosen for FDC development based on variety of purposes such as Pharmacokinetic profile, drug-drug interactions, mechanism of action, and manufacturability for successful development. Tablet in tablet technology has

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Luke, Stefani, Martha Ervina, and Lannie Hadisoewignyo. "Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect." Indonesian Journal of Pharmaceutical Research 1, no. 1 (2021): 19–27. http://dx.doi.org/10.31869/ijpr.v1i1.1993.

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White pomegranate peel has many kinds uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablet can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using direct compression method and then coated using Kollicoat Protect. The optimization of coating formula was performed using a factorial design with design expert software ver 10.0. Responses

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Aura Nasyafa, Novita Indira Sari, Lili Sa’adah, Nur Asyifa Ramadhanti, and Tiara Maulida. "Formulasi Dan Evaluasi Sedian Tablet Dengan Metode Kempa Langsung." Jurnal Sains Farmasi Dan Kesehatan 2, no. 2 (2024): 109–13. https://doi.org/10.62379/jfkes.v2i2.1790.

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The objective of this research is to study the formulation and evaluation of tablet preparations using the direct compression method. The method used in this research is a Systematic Literature Review. The findings of the study explain that the direct compression method is an efficient and economical technique in tablet production, especially in the pharmaceutical industry. With the advancement of technology, this method is increasingly used to produce tablets directly from a mixture of active ingredients and excipients without going through granulation processes, whether wet or dry. This proc

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V.T. Iswariya, Sitawar Anusha, Varada Bala Gnana Laxmi, and Akshay. "FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF SITAGLIPTIN." International Journal of Scientific Research in Modern Science and Technology 3, no. 6 (2024): 01–08. http://dx.doi.org/10.59828/ijsrmst.v3i6.214.

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This study aimed to develop a novel gastro-retentive drug delivery system in the form of floating tablets containing the antidiabetic medication sitagliptin. Sitagliptin acts by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which helps break down hormones released by the gut in response to food intake, including glucagon-like peptide-1 (GLP-1).The tablets contains Pectin and HPMC K as binders, with lactose monohydrate serving as a diluent. The effervescent agent, utilizing Citric acid as a gas-generating agent, was the basis for causing the tablet to float. Magnesium stearate and talc

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Pingale, Prashant L. "FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF METADOXINE TABLETS PREPARED BY VARIOUS GRANULATION METHODS." Journal of Medical pharmaceutical and allied sciences 10, no. 2 (2021): 2712–19. http://dx.doi.org/10.22270/jmpas.v10i2.1066.

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Pharmaceutical tablets are robust, flat, or biconvex dishes, according to the Indian Pharmacopoeia. Depending on a range of medicinal substances, they vary in shape and differ greatly in size and weight. In the era of increasing health awareness and strict standards set by regulatory authorities such as the US FDA, WHO, and globalization, it has become mandatory for the producer to launch a product cost-effectively. In the tablet dosage form, two classes of drugs are administered orally. Narrow extensions of the parietal peritoneum that suspend the diaphragm's liver are the right and left coro

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Balasaheb, B. Karad* Dr. Ajay D. Shinde. "FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LEVONORGESTREL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 471–79. https://doi.org/10.5281/zenodo.1036472.

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The study was undertaken with an aim to develop and optimized formulation of Hormonal contraceptive, Levonorgestrel by oral drug delivery. Pre-formulation studies were conducted to know the drug excipient compatibilities. The superdisintegrants crospovidone and sodium starch glycolate were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipient interaction was investigated by FTIR. All formulation showed compliances with the pharmacopoeial standard. The study reveals that formulat

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Komal, Chavan Pratik Dhotre*. "Research Papar on Formulation and Evalition of Herbal Tablet for Hypertension." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1270–77. https://doi.org/10.5281/zenodo.15609741.

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The present study focuses on the formulation and evaluation of a herbal tablet intended for the management of hypertension, utilizing the medicinal properties of Ocimum sanctum (Tulsi), Coleus forskolin(Coleus), and Allium sativum (Garlic). These herbs are well-documented for their antihypertensive, cardioprotective, and antioxidant activities. The herbal extracts were standardized and incorporated into tablet formulations using direct compression methods with suitable excipients. Pre-compression parameters like bulk density, tapped density, Carr’s index and Hausner’s ratio were ev

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