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Journal articles on the topic 'COMT'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

&NA;. "COMT inhibitors." Inpharma Weekly &NA;, no. 1135 (1998): 6. http://dx.doi.org/10.2165/00128413-199811350-00009.

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Meloto, Carolina B., Samantha K. Segall, Shad Smith, et al. "COMT gene locus." PAIN 156, no. 10 (2015): 2072–83. http://dx.doi.org/10.1097/j.pain.0000000000000273.

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3

O’Tuathaigh, Colm. "S.12.2 - COMT." Behavioural Pharmacology 24 (October 2013): e15. http://dx.doi.org/10.1097/01.fbp.0000434735.74603.db.

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4

Papaleo, F., M. C. Burdick, J. H. Callicott, and D. R. Weinberger. "COMT–Dysbindin epistatic interaction." Molecular Psychiatry 19, no. 3 (2014): 273. http://dx.doi.org/10.1038/mp.2014.6.

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5

Adler, Charles H. "COMT Inhibitors: Novel Treatments for Parkinson's Disease." CNS Spectrums 3, no. 2 (1998): 53–56. http://dx.doi.org/10.1017/s109285290000554x.

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AbstractCatechol-O-methyltransferase (COMT) inhibitors are a new class of medication being developed for the treatment of Parkinson's disease (PD). The enzyme COMT metabolizes levodopa and dopamine, both peripherally and centrally. Coadministration of a COMT inhibitor with levodopa creates an increase in peripheral and central levodopa bioavailability, as well as higher central dopamine concentrations. Because these actions improve the duration of response to levodopa, the COMT inhibitors should prove to be useful adjunctive therapies in PD patients.

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6

Wang, Ruike, Sai Li, Xiuhai Wang, et al. "Association between COMT -287A/G (rs2075507) polymorphism and preeclampsia in a Chinese Han population." International Journal of Sciences Volume 5, no. 2016-03 (2016): 137–42. https://doi.org/10.5281/zenodo.3349151.

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Previous study indicated that COMT might play a significant role in the development of preeclampsia(PE). The purpose of our study is to investigate the association of COMT -287A/G polymorphism (rs2075507) with PE susceptibility in Chinese han population. 505 PE patients and 824 normal pregnant women were enrolled in our research. All the subjects were detected the genotype of COMT -287 loci by Polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) method. Demographics and clinical data were performed using t test or Mann-Whitney test. The frequencies of the allelic and

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7

Zammit, Stanley, Michael J. Owen, Jonathan Evans, Jon Heron, and Glyn Lewis. "Cannabis, COMT and psychotic experiences." British Journal of Psychiatry 199, no. 5 (2011): 380–85. http://dx.doi.org/10.1192/bjp.bp.111.091421.

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BackgroundA putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.AimsTo examine whether the relative risk of developing psychosis following use of cannabis is dependent upon variation within COMT.MethodA longitudinal study of 2630 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort who completed questionnaire-based assessments for cannabis use at age 14 and incident psychotic experiences at age 16. Six SNPs within COMT were genotyped.R

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8

Jiao, Meng, Christopher J. Pirozzi, Chen Yu, et al. "Abstract LB280: Enhancing glioblastoma radiotherapy by COMT inhibition." Cancer Research 84, no. 7_Supplement (2024): LB280. http://dx.doi.org/10.1158/1538-7445.am2024-lb280.

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Abstract There is an urgent unmet medical need to discover novel therapeutics to enhance the efficacy of glioma radiotherapy. Here we assessed the roles of catechol - o - methyltransferase COMT, a key enzyme in dopamine metabolism and a drug target for Parkinson's disease, in glioma treatment. Analysis of TCGA data showed significantly higher COMT expression levels in glioma versus normal brain tissues. Inhibition of COMT by genetic knockout or FDA - approved COMT inhibitors significantly sensitized glioma cells to radiotherapy in vitro and murine glioma in vivo. Mechanistically, COMT inhibiti

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Semen, M. O., O. L. Lychkovska, I. E. Shymanska, V. D. Semen, and H. V. Makukh. "High frequency of the 472AA COMT (Val158) homozygous genotype of the catechol-O-methyltransferase (COMT) gene in children with irritable bowel syndrome." Modern pediatrics. Ukraine, no. 6(126) (October 29, 2022): 23–29. http://dx.doi.org/10.15574/sp.2022.126.23.

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Following the biopsychosocial model of medicine, the pathophysiological basis of irritable bowel syndrome (IBS) is a combination of biological, psychoemotional, and psychosocial factors, the contribution of each of them to the development of this disorder remains unclear. Psychoemotinal factors, which are involved in the pathogenesis of IBS, are caused not only by the environment but also by the metabolism of catecholamines, particularly by the functional activity of catechol-O-methyltransferase (COMT). Purpose - to determine the role of Val158Met COMT polymorphism in development of IBS in chi

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10

Belfer, I., and S. Segall. "COMT genetic variants and pain." Drugs of Today 47, no. 6 (2011): 457. http://dx.doi.org/10.1358/dot.2011.47.6.1611895.

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11

Martinez-Martin, P., and C. F. O'Brien. "Extending levodopa action: COMT inhibition." Neurology 50, Issue 6, Supplement 6 (1998): S27—S32. http://dx.doi.org/10.1212/wnl.50.6_suppl_6.s27.

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12

Dorflinger, E., G. Magni, and F. Hoffmann. "COMT inhibition and Parkinson's disease." European Neuropsychopharmacology 8 (November 1998): S87—S88. http://dx.doi.org/10.1016/s0924-977x(98)80057-6.

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13

Buckley, P. F. "Cannabis, COMT and psychotic experiences." Yearbook of Psychiatry and Applied Mental Health 2013 (January 2013): 384. http://dx.doi.org/10.1016/j.ypsy.2012.07.004.

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14

Abi-Dargham, Anissa, J. Ekelund, B. Kolachana, et al. "Cortical D1 across COMT genotypes." NeuroImage 31 (January 2006): T40. http://dx.doi.org/10.1016/j.neuroimage.2006.04.030.

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15

Rivest, Jean, C. Lynn Barclay, and Oksana Suchowersky. "COMT Inhibitors in Parkinson's Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 26, S2 (1999): S34—S38. http://dx.doi.org/10.1017/s031716710000007x.

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The COMT inhibitors, tolcapone and entacapone, are a new class of Parkinson's medications. By inhibiting the enzyme catechol-o-methyl-transferase (COMT), they prevent peripheral degradation of levodopa, allowing a higher concentration to cross the blood-brain barrier. Pharmacokinetic studies have shown that both tolcapone and entacapone significantly prolong the elimination half life, and increase the area under the curve of levodopa without increasing C max. Clinical studies with COMT inhibitors have shown benefit in both stable and fluctuating PD patients with improvement in motor function w

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16

Arboleya, Luis. "COMT Gene Polymorphisms and Fibromyalgia." Reumatología Clínica (English Edition) 3, no. 1 (2007): 48–49. http://dx.doi.org/10.1016/s2173-5743(07)70209-5.

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17

Reichmann, Heinz. "Opicapon: ein neuer COMT-Hemmer." InFo Neurologie & Psychiatrie 19, no. 5 (2017): 18–19. http://dx.doi.org/10.1007/s15005-017-2173-6.

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18

Baier, Monika, Ekkehard Haen, and Peter Lauer. "COMT-Polymorphismus und GST-Mangel." NeuroTransmitter 24, no. 4 (2013): 49–52. http://dx.doi.org/10.1007/s15016-013-0140-0.

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19

Smith, Shad B., Ilkka Reenilä, Pekka T. Männistö, et al. "Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain." Pain 155, no. 11 (2014): 2390–99. http://dx.doi.org/10.1016/j.pain.2014.09.009.

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20

Silva, Anderson Matheus Pereira da, Victoria Brito Evangelista, Ilan Iginio da Silva, et al. "IDENTIFICAÇÃO E CARACTERIZAÇÃO POLIMÓRFICA DA CATECOL-O-METILTRANSFERASE (COMT): UMA REVISÃO DA LITERATURA." Centro de Pesquisas Avançadas em Qualidade de Vida 16, V16N2 (2024): 1. http://dx.doi.org/10.36692/v16n2-53r.

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A enzima catecol-O-metiltransferase (COMT) desempenha um papel crucial no metabolismo das catecolaminas, neurotransmissores essenciais para diversas funções cerebrais e periféricas.Objetivo: Este artigo aborda a importância da COMT, destacando sua relevância no tratamento de doenças neurodegenerativas e psiquiátricas, bem como sua associação com variações genéticas, especialmente o polimorfismo Val158Met. Metodologia: Através de uma revisão abrangente da literatura, são discutidos aspectos como a estrutura e função da COMT, os efeitos de inibidores da enzima, como tolcapona e entacapona, e as

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21

Hamongan Nasution, Akhyar, and Aznan Lelo. "CATECHOL-O-METHYLTRANSFERASE (COMT) ENZYME LEVELS IN PATIENTS WITH PREOPERATIVE ANXIETY." PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) 1, no. 1 (2022): 33–40. http://dx.doi.org/10.55047/comorbid.v1i1.37.

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 The preoperative anxiety’s incidence is very high and mostly preoperative patients have anxiety. It was found that low COMT levels indicate a tendency to develop anxiety. Hence, this study aims to investigate COMT enzyme levels in patients with preoperative anxiety. This research is a purely experimental research with a pretest-posttest control group design and double-blind. Measurement of COMT enzyme levels was executed by utilizing ELISA technique. Blood samples were taken from preoperative anxiety patients who were assessed with the Amsterdam Preoperative Anxiety Information Scale (A

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22

Rosli, Norsuhaila Rosmimi, Tengku Shahrul Anuar engku Ahmad Basri, Mohd Ilham Adenan, et al. "Association of COMT Polymorphism and Academic Achievement among Female Undergraduate Students." Science Letters 15, no. 2 (2021): 90–101. http://dx.doi.org/10.24191/sl.v15i2.13831.

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Academic achievement may be influenced by catechol-O-methyltransferase (COMT) polymorphism. A common functional polymorphism of COMT, the rs4680 is consistently being involved in the modulation of dopaminergic pathway and prefrontal cortex function which may predominantly affect cognitive functions. A total of 197 female participants were recruited in this study. The score of student’s grade point average (GPA) from the latest previous semester was used as the measurement of academic achievement. The COMT polymorphism was genotyped using tetra primer allele specific polymerase chain reaction.

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23

Hamonangan Nasution, Akhyar, and Aznan Lelo. "Catechol-O-Methyltransferase (COMT) Enzyme Level In Preoperative Anxiety Patients." Journal of Society Medicine 1, no. 1 (2022): 25–30. http://dx.doi.org/10.47353/jsocmed.v1i1.5.

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Background: Incidence of perioperative anxiety is very high, many preoperative patient experience anxiety . Thiamine acts as an essential nutrition funtionate as cofactor enzyme in most of mitochondria in brain. Brain is very susceptible to thiamine deficiency because its dependency on mitochondrial ATP production. Decreased ATP production result in inhibition of COMT activity. Low COMT levels indicated tendency for anxiety. The aim of this study is to determine the effect of thiamine in increasing COMT enzyme levels in patient with preoperative anxiety Methods : A true experiment with p

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24

Kim, Jin-Hee, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, and Minsun Chang. "Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells." Molecules 26, no. 7 (2021): 2060. http://dx.doi.org/10.3390/molecules26072060.

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Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to treat various diseases. In breast tissue, estradiol is metabolized to the catechol estrogens such as 4-hydroxyestradiol (4-OHE2), which have been proposed to be cancer initiators potentially involved in mammary carcinogenesis. Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens to their less toxic methoxy derivatives, such as 4-O-methylestradiol (4-MeOE2). The present study investigated the novel biological activities of NDGA in relatio

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25

de Castro-Catala, Marta, Neus Barrantes-Vidal, Tamara Sheinbaum, Artal Moreno-Fortuny, Thomas R. Kwapil, and Araceli Rosa. "COMT-by-Sex Interaction Effect on Psychosis Proneness." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/829237.

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Schizotypy phenotypes in the general population share etiopathogenic mechanisms and risk factors with schizophrenia, supporting the notion of psychosis as a continuum ranging from nonclinical to clinical deviance. Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex. Several recent studies have reported a sex difference in the impact of COMT genotype on psychiatric and cognitive phenotypes and personality traits. The present study investigated the association of COMT Val158Met (rs4680) w

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26

Mir, Rashid, Musadiq Bhat, Jamsheed Javid, Chandan Jha, Alpana Saxena, and Shaheen Banu. "Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease." Journal of Cardiovascular Development and Disease 5, no. 3 (2018): 38. http://dx.doi.org/10.3390/jcdd5030038.

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Purpose: Catechol-O-methyltransferase (COMT) plays a central role in DNA repair and estrogen-induced carcinogenesis. The nonsynonymous single nucleotide polymorphism (SNP) in exon 4 G > A or Val108 > 158Met or rs4680 G > A influences COMT enzyme activity. The three phenotypes of the COMT enzyme activities include COMT A/A with low enzyme activity, COMT A/G with medium enzyme activity and COMT G/G with high enzyme activity. The Met allele is associated with low enzymatic activity resulting in higher levels of prefrontal dopamine. Conversely, the Val allele is associated with high enzym

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27

Šanjug, Jadranka, Krunoslav Kuna, Marina Šprem Goldštajn, Lidija Fumić Dunkić, Andreja Carek, and Dubravka Negovetić Vranić. "Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour." Journal of Clinical Medicine 12, no. 19 (2023): 6298. http://dx.doi.org/10.3390/jcm12196298.

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Background: The COMT gene polymorphism is associated with neurological and psychiatric disorders and pain perception. The present study investigates the existence of anxiety and pain perception in relation to the COMT (catechol-O-methyltransferase) gene polymorphism in labouring women (during “natural” childbirth) with or without inhaled analgesia. Methods: A total of 181 women who chose vaginal birth were enrolled in this study. To present the difference in pain perception, the parturients were divided into one group (n = 90) that chose labour analgesia with inhaled nitrous oxide (50% nitrous

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28

Pacheco-Romero, José, Doris Huerta, Oscar Acosta, and Santiago Cabrera. "Polimorfismo en el gen COMT en una muestra de gestantes normales y con restricción del crecimiento intrauterino en un hospital de Lima." Anales de la Facultad de Medicina 74, no. 2 (2013): 129. http://dx.doi.org/10.15381/anales.v74i2.2385.

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Antecedentes: Los procesos fisiopatológicos que ocurren a nivel celular y molecular en la restricción de crecimiento intrauterino (RCIU) son aún desconocidos. La catecol-O-metiltransferasa (COMT) es una enzima de fase II que inactiva los catecol estrógenos al transferir un grupo metílico. Se conoce un polimorfismo funcional Val158 Met en el gen COMT como un marcador susceptible para diversas enfermedades maternoperinatales, existiendo estudios que sugieren que el alelo que codifica una COMT de baja actividad puede ser un marcador susceptible para RCIU. Por lo tanto, el estudio del polimorfismo

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29

Yang, Xiaolei, Jinghuan Zhang, and Shun Zhang. "No association of COMT with insight problem solving in Chinese college students." PeerJ 7 (April 15, 2019): e6755. http://dx.doi.org/10.7717/peerj.6755.

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Genes involved in dopamine (DA) neurotransmission, such as the catechol-O-methyltransferase gene (COMT), have been suggested as key genetic candidates that might underlie the genetic basis of insight. In a sample of Chinese college students, this study examined whether COMT was associated with individual differences in the ability to solve classic insight problems. The results demonstrated that COMT was not associated with insight problem solving and there was no gender-dependent effect. This study, together with previous studies, raises the possibility of a complex relationship between COMT a

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30

Bramon, E., E. Dempster, S. Frangou, et al. "Is there an association between the COMT gene and P300 endophenotypes?" European Psychiatry 21, no. 1 (2006): 70–73. http://dx.doi.org/10.1016/j.eurpsy.2005.11.001.

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AbstractP300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, t

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31

Moraes, Leopoldo Silva de, Marcelina Ribeiro da Silva, Lorena Araújo da Cunha, Simone Machado da Rocha, and Carlos Alberto Machado da Rocha. "Gene COMT e sua possível relação com a esquizofrenia." Genética na Escola 14, no. 1 (2019): 78–85. http://dx.doi.org/10.55838/1980-3540.ge.2019.313.

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A esquizofrenia é um transtorno psiquiátrico grave e acomete pessoas de todas as classes sociais. Caracterizado por sintomas positivos como psicose, delírios e alucinações, e sintomas negativos como retraimento social e distanciamento afetivo, que são causados por diversos fatores biopsicossociais; fatores genéticos podem estar intimamente relacionados ao desenvolvimento desta doença. Neste artigo é abordada uma possível relação do gene COMT com o aparecimento de alterações cerebrais envolvidas no surgimento da esquizofrenia. O gene COMT localizase no braço longo do cromossomo 22, codifica a e

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32

Brooks, D. J. "Safety and tolerability of COMT inhibitors." Neurology 62, Issue 1, Supplement 1 (2004): S39—S46. http://dx.doi.org/10.1212/wnl.62.1_suppl_1.s39.

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33

Kuhn, W., D. Woitalla, H. Russ, M. Gerlach, and Th Müller. "Potentielle Risiken zentral wirksamer COMT-Hemmer." Aktuelle Neurologie 25, S 4 (1998): S277—S278. http://dx.doi.org/10.1055/s-2007-1017744.

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34

Greenwood, Jessica, Huy Pham, and Jose Rey. "Opicapone: A third generation COMT inhibitor." Clinical Parkinsonism & Related Disorders 4 (2021): 100083. http://dx.doi.org/10.1016/j.prdoa.2020.100083.

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35

Grant, Jon E., Eric W. Leppink, Sarah A. Redden, Brian L. Odlaug, and Samuel R. Chamberlain. "COMT genotype, gambling activity, and cognition." Journal of Psychiatric Research 68 (September 2015): 371–76. http://dx.doi.org/10.1016/j.jpsychires.2015.04.029.

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36

Lee, C. T., and H. K. Lee. "COMT gene polymorphism in alcohol dependence." European Neuropsychopharmacology 12 (October 2002): 388. http://dx.doi.org/10.1016/s0924-977x(02)80640-x.

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Sand, P., P. Eichhammer, A. Putzhammer, et al. "P.6.063 COMT haplotypes in schizophrenia." European Neuropsychopharmacology 13 (October 2003): S452. http://dx.doi.org/10.1016/s0924-977x(03)92361-3.

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38

Arboleya, Luis. "Polimorfismos del gen COMT y fibromialgia." Reumatología Clínica 3, no. 1 (2007): 48–49. http://dx.doi.org/10.1016/s1699-258x(07)73599-4.

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39

McCarthy, Jeanette J. "COMT and schizophrenia: biology meets genetics." Trends in Biotechnology 19, no. 8 (2001): 283–84. http://dx.doi.org/10.1016/s0167-7799(01)01747-4.

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40

Nissinen, Erkki. "Chemistry and biochemistry of COMT inhibitors." European Journal of Pharmaceutical Sciences 34, no. 1 (2008): S7—S8. http://dx.doi.org/10.1016/j.ejps.2008.02.017.

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41

Bramon, E., E. Dempster, S. Frangou, et al. "¿Hay una asociación entre el gen de la COMT y los endofenotipos de la onda P300?" European psychiatry (Ed. Española) 13, no. 5 (2006): 244–48. http://dx.doi.org/10.1017/s1134066500005208.

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ResumenLas anomalías de la onda P300 correlacionan con el riesgo genético de esquizofrenia y constituyen un enfofenotipo plausible para la enfermedad. Se piensa que el gen de la COMT influye en la ejecución cognitiva y es un gen de susceptibilidad para la esquizofrenia. A diferencia de dos estudios anteriores, no encontramos influencia significativa del gen de la COMT en la amplitud o la latencia de la onda P300 en 189 individuos examinados. El papel bien respaldado del gen de la COMT tanto en el catabolismo de la dopamina como en la cognición prefrontal constituye un fuerte argumento teórico

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Суханов, А. В., С. Е. Семаев, and В. Н. Максимов. "Associations of separate working memory parameters with comt genotypes in Western Siberia." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 6() (June 28, 2019): 43–49. http://dx.doi.org/10.25557/2073-7998.2019.06.43-49.

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Цель. Изучить ассоциации отдельных параметров оперативной памяти с полиморфным локусом Val158Met (rs4680) гена COMT у лиц молодого возраста. Материалы и методы. 371 участник 25-44 лет отобран из популяционной выборки г. Новосибирска. Исследование включало 199 (53,6%) мужчин (36,54 ± 5,67 года) и 172 (46,4%) женщины (36,84 ± 5,75 года). Когнитивные функции оценивались стандартизованными для целей скрининга методами: запоминание 10-ти слов по методике А.Р. Лурия, корректурная проба Бурдона, методика исключения понятий (словесный вариант теста) с фиксацией времени её выполнения, а также тест на р

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43

Krzizike, Daniel D., Margie L. Clapper, and Andrew J. Andrews. "Abstract 2345: Specificity of catechol-O-methyltransferase (COMT) for hydroxyestrogens favors 2-OHEs over 4-OHEs." Cancer Research 82, no. 12_Supplement (2022): 2345. http://dx.doi.org/10.1158/1538-7445.am2022-2345.

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Abstract The contribution of estrogen receptor-mediated signaling to cancer progression and metastasis has been well documented. However, much less attention has been given to the role of estrogen metabolism in carcinogenesis. Parent estrogens are metabolized to 2- and 4-hydroxyestrogens (2-OHEs and 4-OHEs) that can retain their estrogenic activity, form reactive quinones that cause DNA damage, or become inactivated primarily by the rate-limiting conjugation enzyme catechol-O-methyltransferase (COMT). The ability of 4-OHEs to induce genomic instability and the malignant transformation of human

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44

Khalil, Heba, Susan M. Sereika, Feng Dai, et al. "OPRM1 and COMT Gene–Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma." Biological Research For Nursing 19, no. 2 (2016): 170–79. http://dx.doi.org/10.1177/1099800416680474.

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Background: mu-opioid receptor ( OPRM1) and catechol-O-methyltransferase ( COMT) contribute to the neurotransmission pathway of pain. COMT affects mu receptor expression and density in the brain. The aim of this study was to explore the OPRM1 and COMT interaction effects on postoperative pain and opioid consumption. Methods: This cross-sectional exploratory study used genotype and clinical data from 153 postoperative patients. Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered f

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45

Gong, L., C. He, Y. Yin, et al. "Nonlinear modulation of interacting between COMT and depression on brain function." European Psychiatry 45 (September 2017): 6–13. http://dx.doi.org/10.1016/j.eurpsy.2017.05.024.

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AbstractBackground:The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear.Methods:Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene po

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STEFANIS, NICHOLAS C., CÉCILE HENQUET, DIMITRIOS AVRAMOPOULOS, et al. "COMT Val158Met moderation of stress-induced psychosis." Psychological Medicine 37, no. 11 (2007): 1651–56. http://dx.doi.org/10.1017/s0033291707001080.

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ABSTRACTBackgroundExposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val158Met) gene moderates the psychosis-inducing effects of stress.MethodA semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19–24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed con

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Yadav, Sharawan, Naveen Kumar Singhal, Virendra Singh, Neeraj Rastogi, Pramod Kumar Srivastava, and Mahendra Pratap Singh. "Association of Single Nucleotide Polymorphisms in CYP1B1 and COMT Genes with Breast Cancer Susceptibility in Indian Women." Disease Markers 27, no. 5 (2009): 203–10. http://dx.doi.org/10.1155/2009/346497.

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Cytochrome P450 1B1 (CYP1B1) and catechol-$O$-methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. The present study was performed to evaluate the associations of CYP1B1 Leu432Val and/or COMT Val1

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Hashimoto, Yutaka, Marisa Shiina, Shigekatsu Maekawa, et al. "Suppressor effect of catechol-O-methyltransferase gene in prostate cancer." PLOS ONE 16, no. 9 (2021): e0253877. http://dx.doi.org/10.1371/journal.pone.0253877.

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Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds. In this study, we determined the functional effects and regulation of COMT in prostate cancer. Both the Cancer Genome Atlas (TCGA) and immunohistochemical analysis of clinical specimens demonstrated a reduction of COMT expression in prostate cancer. Also, western analyses of prostate cancer cell lines show COMT levels to be minimal in DuPro and DU145 and thus, these cells were used for further analyses. Re-express

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Janacova, Lucia, Michaela Stenckova, Petr Lapcik, et al. "Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer." Scientific Reports 13, no. 1 (2023): 1285. https://doi.org/10.1038/s41598-023-28078-1.

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Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells. To delineate COMT role in metastasis of estrogen receptor (ER) dependent BC, we investigated the effect of COMT overexpression on invasion, transcriptome, proteome and interactome of MCF7 cells, a luminal A BC model, stably transduced with lentiviral vector carrying COMT gene (MCF7-COMT). 2D and 3D assays revealed that COMT overexpression associates with decre

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Männistö, Pekka T., and Seppo Kaakkola. "Catechol-O-methyltransferase (COMT): Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors." Pharmacological Reviews 51, no. 4 (1999): 593–628. https://doi.org/10.1016/s0031-6997(24)01423-6.

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