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Journal articles on the topic 'Concept of futile therapy'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Elmadhoun, Ahmed, Hongrui Wang, and Yuchuan Ding. "Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke." Brain Circulation 10, no. 1 (2024): 1–4. http://dx.doi.org/10.4103/bc.bc_9_24.

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Abstract: Acute ischemic stroke (AIS) remains to be a challenging cerebrovascular disease. The mainstay of AIS management is endovascular reperfusion therapy, including thrombectomy and thrombolysis. However, ineffective (futile) reperfusion (FR) or reperfusion injury (RI) can be seen in a significant number of patients undergoing reperfusion strategy. In this article, we discuss two clinically relevant concepts known as “time window” and “tissue window” that can impact the clinical outcome of reperfusion therapy. We also explore patient risk factors, leading to FR and RI as well as an emergin

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2

Boratyńska, Maria. "Legal and Ethical Issues of Discontinuing Futile Therapy in Children." Białostockie Studia Prawnicze 28, no. 3 (2023): 125–58. http://dx.doi.org/10.15290/bsp.2023.28.03.06.

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Abstract This article raises the issue of critical medical decisions made in the interest of small children. It seeks answers to the questions of whether there are any differences in this field’s attitude towards adults and what the criteria for life and death decisions should be for persons who are legally dependent and unable to declare their position. The concept of so-called parental autonomy in making treatment decisions for children and situations in which they may be limited by the assessment of doctors and by the supervisory function of the guardianship court. The overriding principle

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Świderska, Małgorzata A. "Legal Aspects of Futile Therapy in the Face of the End of Life." Białostockie Studia Prawnicze 28, no. 3 (2023): 71–107. http://dx.doi.org/10.15290/bsp.2023.28.03.04.

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Abstract This article presents legal issues related to therapeutic decisions made by doctors and to euthanasia and assisted suicide, which are prohibited and penalized in the Polish legal system. The paper refers to the terms ‘futile therapy’ and ‘over-zealous treatment’. It was also considered appropriate to refer to the concept of resuscitation, which can be understood narrowly as cardiopulmonary resuscitation or broadly as all activities aimed at potentially reversing the dying process. Completion of resuscitation as it is broadly understood means that (unless there has been recovery) it is

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Jóźwiak, Aleksandra, Rafał Rutyna, Anna Fijałkowska-Nestorowicz, Magdalena Bielacz, Walery Zukow, and Edyta Kotlińska-Hasiec. "Implementation of the futile therapy concept in the conditions of Polish intensive care units - a description of five cases." Journal of Education, Health and Sport 9, no. 8 (2019): 11–28. https://doi.org/10.5281/zenodo.3370046.

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<strong>Jóźwiak Aleksandra, Rutyna Rafał, Fijałkowska-Nestorowicz Anna, Bielacz Magdalena, Zukow Walery, Kotlińska-Hasiec Edyta</strong><strong>. </strong><strong>Implementation of the futile therapy concept in the conditions of Polish intensive care units - a description of five cases</strong><strong>. Journal of Education, Health and Sport. 2019;9(</strong><strong>8</strong><strong>):</strong><strong>11</strong><strong>-</strong><strong>28</strong><strong>. eISNN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3358866</strong> <strong>http://ojs.ukw.edu.pl/index.php/j

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Murrock, Carolyn J., and Abir K. Bekhet. "Concept Analysis: Music Therapy." Research and Theory for Nursing Practice 30, no. 1 (2016): 44–59. http://dx.doi.org/10.1891/1541-6577.30.1.44.

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Down through the ages, music has been universally valued for its therapeutic properties based on the psychological and physiological responses in humans. However, the underlying mechanisms of the psychological and physiological responses to music have been poorly identified and defined. Without clarification, a concept can be misused, thereby diminishing its importance for application to nursing research and practice. The purpose of this article was for the clarification of the concept of music therapy based on Walker and Avant’s concept analysis strategy. A review of recent nursing and health

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Boratyńska, Maria, and Jacek Malczewski. "Spór o zaprzestanie daremnej terapii oraz sztucznego odżywiania i nawadniania na przykładzie sprawy polskiego pacjenta RS w Wielkiej Brytanii." Przegląd Prawa Medycznego 3, no. 1-2 (2021): 171–236. http://dx.doi.org/10.70537/843dw292.

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The article describes and comments upon a recent decision of the British Court of Protection which authorised the cessation of futile life-sustaining therapy including clinically assisted nutrition and hydration (CANH) from RS, a middle-aged Polish patient who fell into the permanent vegetative state (PVS) caused by severe brain damage. The authors scrutinize the legal proceedings and discuss the “best interests” criterion applied by Mr. Judge Cohen (the famous Bland case as well as the Mental Capacity Act of 2005 are evoked in this context). Several terminological and ethical issues are also

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Bender, N. "Gene therapy: a concept for the future in medical practice?" Hämostaseologie 24, no. 03 (2004): 173–78. http://dx.doi.org/10.1055/s-0037-1619633.

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SummaryGene therapy is a new therapeutic approach which is tested in numerous diseases connected with either non or only limited therapeutic effects. This paper aims at discussing the actual state of the clinical development of gene-therapy which targets an approval by either the FDA or EMEA. Basis of all the figures and tables presented is a BioMedNet/Medline search reviewing all titles found under the keywords gene therapy and/or clinical development. The review period begins in the year 1992 and ends in 2002. Publications identified were sorted into the following categories: therapeutic are

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Wakabayashi, Kenji. "Importance of the team medicine in periodontal therapy -Future concept of periodontal therapy-." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 57, no. 1 (2015): 26–29. http://dx.doi.org/10.2329/perio.57.26.

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Kidoguchi, Satoshi, Naoki Sugano, Gorou Tokudome, et al. "New Concept of Onco-Hypertension and Future Perspectives." Hypertension 77, no. 1 (2021): 16–27. http://dx.doi.org/10.1161/hypertensionaha.120.16044.

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Owing to aging populations, the prevalence of hypertension and associated cardiovascular events has been increasing worldwide. The morbidity and mortality due to cancer have also been increasing with aging populations. Several small-molecule inhibitors have been used in cancer therapy, which have a positive impact on the prognosis and survival of patients with cancer. Consequently, the number of cancer survivors with hypertension has been rapidly increasing. Anticancer therapy, including vascular endothelial growth factor inhibitors, increases blood pressure. However, both clinical and laborat

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Mulbrain, M. "Four D concept of fluid therapy." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 193–95. http://dx.doi.org/10.32902/2663-0338-2020-3.2-193-195.

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Background. D (definition): the daily fluid balance is the sum of all the amounts of consumed and excreted fluid. Assessment of fluid accumulation per day allows to detect fluid overload. At early stages (the first 1-3 hours) of infusion therapy (IT) targeted administration of necessary drugs should be carried out. The volume of infusion is 10-30 ml/kg of body weight. Subsequently, during the first week of treatment in the intensive care unit (ICU) it is necessary to achieve two consecutive days with a negative fluid balance. In the later stages of treatment, active fluid removal is performed

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Trbojevic, Dejan. "FFAGs as Accelerators and Beam Delivery Devices for Ion Cancer Therapy." Reviews of Accelerator Science and Technology 02, no. 01 (2009): 229–51. http://dx.doi.org/10.1142/s1793626809000223.

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First, a review is given of fixed field alternating gradient (FFAG) accelerators, presenting a bit of their history and basic concepts. Special attention is paid to the concept of scaling (S-FFAG) and nonscaling (NS-FFAG) FFAGs. This notation is used only in the NS-FFAG part of the article. A discussion is then provided on operating FFAGs. A presentation is made of the designs being considered for S-FFAGs. A bit more is said about the concept of the NS-FFAG and a resonance crossing problem resulting from designs of the NS-FFAGs. A beam delivery system (gantry) employing the NS-FFAG concept is

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Vajaratkar, Pooja Vivek, and A. K. Dwivedi. "Conceptualizing Spirituality in Occupational Therapy Practice: A Systematic Review." Indian Journal of Occupational Therapy 55, no. 3 (2023): 86–90. http://dx.doi.org/10.4103/ijoth.ijoth_9_22.

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Abstract Background: Spirituality is a key domain of occupational therapy practice, and for some individuals and communities, all occupations are viewed as spiritual. However, occupational therapists find conceptualizing spirituality and its meaning for both themselves and their patients challenging. The purpose of this concept analysis was to clarify the concept of spirituality and provide occupational therapists with guidance on how to integrate spirituality into practice. Objectives: This concept analysis was to clarify the concept of spirituality and how it has been articulated in studies.

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Rosado, Amanda. "Adolescents’ Experiences of Music Therapy in an Inpatient Crisis Stabilization Unit." Music Therapy Perspectives 37, no. 2 (2019): 133–40. http://dx.doi.org/10.1093/mtp/miz004.

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Abstract Fourteen adolescents on an inpatient crisis stabilization unit were interviewed about their experiences of group music therapy in order to understand how sessions impacted their mental health recovery. Using analytic procedures consistent with qualitative content analysis, 13 preliminary themes captured their session experiences. From these themes, 4 central concepts emerged: (1) music therapy affirms participants’ strengths, (2) music therapy affirms coping resources, (3) music therapy integrates cognitive and affective processes, and (4) music therapy provides continuity of experien

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Mayston, Margaret. "Bobath Concept: Bobath@50: mid-life crisis - What of the future?" Physiotherapy Research International 13, no. 3 (2008): 131–36. http://dx.doi.org/10.1002/pri.413.

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Mahajan, Ajay, Nidhi Chandel, Kanwarjit S. Asi, and Monika S. Walhe. "Managing Periodontitis with Host Modulation Therapy: Current Concept and Future Perspective." Dental Journal of Advance Studies 12, no. 1 (2024): 29–33. http://dx.doi.org/10.5005/djas-11014-0035.

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Lu, Chaohui, Junru Liao, and Xu Wang. "Research Progress of Mrna Therapy: From Concept to Clinic." Highlights in Science, Engineering and Technology 102 (July 11, 2024): 821–32. http://dx.doi.org/10.54097/qbqpn744.

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mRNA therapeutics have emerged as a highly promising approach with the potential to revolutionize disease treatment. This review is to provide a comprehensive exploration of the fundamental principles and practical applications of mRNA therapy, from its conceptualization to clinical experimentation. Through a thorough examination of literature and analysis of clinical trial data, this review highlights the pharmaceutical potential of mRNA, including its adaptable design and efficient production. The advancements made in addressing challenges such as mRNA degradation and immunogenicity through

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Felgner, Sebastian, Dino Kocijancic, Michael Frahm, and Siegfried Weiss. "Bacteria in Cancer Therapy: Renaissance of an Old Concept." International Journal of Microbiology 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/8451728.

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The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base f

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Petrović, Milica, Ljiljana Kesić, Radmila Obradović, et al. "Regenerative periodontal therapy: I part." Acta stomatologica Naissi 37, no. 84 (2021): 2304–13. http://dx.doi.org/10.5937/asn2184304p.

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Introduction: Under the concept of regenerative periodontal therapy, there are two approaches: the first is the passive regeneration conceptthat includes bone substituents and guided periodontal regeneration by using of biomembranes and the second concept of active regeneration that impliesthe use of growth factors. The aim of the passive regeneration, by using of bone matrix (bone substituens) has been stabilization and bone defects management, preventing epithelial tissue growth, as well as saving space for the new tissue regeneration. This concept implies the use of autogenous transplantats

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He, Qianjun. "Precision gas therapy using intelligent nanomedicine." Biomaterials Science 5, no. 11 (2017): 2226–30. http://dx.doi.org/10.1039/c7bm00699c.

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Hazidar, Al Hamidy, Riza Sulaiman, Shalisah Sharip, et al. "Creative Intervention for Acrophobia Sufferers through AIVE Concept." Information 12, no. 7 (2021): 261. http://dx.doi.org/10.3390/info12070261.

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This research applies exposure to the visual appearance technology of virtual reality (VR). The motivation for this research is to generate a creative intervention by using regular smartphone devices and implementing them in VR using Google Cardboard as a medium visual display for exposure therapy at high altitudes. The VR application in this research is called acrophobia immersive virtual exposure (AIVE), which utilizes the Unity3D software to develop this treatment therapy application. The utilization of exposure therapy was carried out as a therapeutic medium for acrophobia sufferers. A com

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Lazenby, J. Mark. "On “spirituality,” “religion,” and “religions”: A concept analysis." Palliative and Supportive Care 8, no. 4 (2010): 469–76. http://dx.doi.org/10.1017/s1478951510000374.

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AbstractObjective:With increasing research on the role of religion and spirituality in the well-being of cancer patients, it is important to define distinctly the concepts that researchers use in these studies.Method:Using the philosophies of Frege and James, this essay argues that the terms “religion” and “spirituality” denote the same concept, a concept that is identified with the Peace/Meaning subscale of the Functional Assessment of Chronic Illness Therapy — Spiritual Well-being Scale (FACIT-Sp).Results:The term “Religions” denotes the concept under which specific religious systems are cat

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Esmaeili, Sasan, Sara Esmaeili, and Aram Zabeti. "Oral Microbiome and Multiple Sclerosis? A Novel Concept!" European Journal of Dental and Oral Health 4, no. 6 (2023): 19–20. http://dx.doi.org/10.24018/ejdent.2023.4.6.305.

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Human oral microbiota refers to the significant number of microorganisms that exist in the human mouth. It is one of the most intricate microbial populations in the human body. Recent studies have suggested the role of the oral microbiome in diverse nervous system diseases. Consequently, investigating the impact of the oral microbiome in patients with Multiple Sclerosis (MS) could reveal potential associations with the disease. In this review, the role of oral microbiota in MS patients has been addressed. The findings of this study hold promise for future approaches to oral and dental health i

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Jameel, Mariyam, Md Tanwir Alam, Arfa Bano, Afeefa Kazmi, and Shabana Noor. "The Unani Concept of Munzij Mushil Therapy: A Systematic Review." Journal of Complementary and Alternative Medical Research 26, no. 7 (2025): 19–34. https://doi.org/10.9734/jocamr/2025/v26i7673.

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Munzij-Mushil therapy, a cornerstone of Unani medicine, focuses on systemic detoxification through concoction (munzij) and purgation (mushil) to restore humoral balance and eliminate morbid substances. This systemic analysis evaluates the efficacy of Munzij-Mushil therapy across 20 published articles on the therapy and related topics and 6 published articles on the related topic of ishal, highlighting its role in chronic diseases, rheumatoid arthritis, hemiplegia, and lymphatic filariasis. Findings indicate significant improvements in biochemical markers, symptom relief, and functional recover

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Jaffray, D. "110 INVITED Image-Guided Radiation Therapy – From Current Concept to Future Perspectives." European Journal of Cancer 47 (September 2011): S27—S28. http://dx.doi.org/10.1016/s0959-8049(11)70325-2.

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Fatma, Aysazcı Çakar. "A Scoping Review: Self-Related Concepts in the context of Narrative Exposure Therapy Research." SOCIAL SCIENCES STUDIES JOURNAL 10, no. 5 (2024): 651–59. https://doi.org/10.5281/zenodo.11371509.

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The concept of "self" holds a pivotal role in psychology and mental health research, prompting significant interest in understanding its implications and dynamics. This scoping review delves into the theoretical association between the concept of "self" and Narrative Exposure Therapy, a therapeutic approach used to address trauma-related psychological distress. The objective of this study is to identify and address a gap in the existing literature concerning the exploration of self-related concepts within the context of NET research. By systematically conducting a comprehensive scoping review,

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WARSTAT, MATTHIAS. "Images of the Future in Drama Therapy." Theatre Research International 34, no. 2 (2009): 180–86. http://dx.doi.org/10.1017/s0307883309004532.

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For various reasons, there is a tension between drama therapy and the concept of performance. Whereas many notions of performance are deeply rooted in the here-and-now, theatrical types of therapy often include practices concerning the future and constructing future images of self, subjectivity and conflict. This paper argues that therapeutic theatre's high affinity with iconic structures and with the creation of ‘images’ can be explained by its specific problems with the contingency and risk inherent in performance.

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Marcvart, Maria. "Ozone therapy - present and perspective." Journal of Ozone Therapy 6, no. 7 (2022): 25. http://dx.doi.org/10.7203/jo3t.6.7.2022.25992.

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This work connects extensive literature research of the last three decades on medical ozone and the personal clinical experience (more than ten years) of ozone therapy. Classical and more recent concepts were considered: hormesis and lowdose concept, ozone action through messenger-molecules – reactive species (well-studied H?O? and 4-HNE), their implication in the redox homeostasis and in cellular signalling and the consecutive cellular response by adaptation or apoptosis. Another issue in the therapy is a correct diagnosis – based on molecular mechanisms. Many current diseases are shari

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Bikbavova, G. R., M. A. Livzan, D. G. Novikov, and E. A. Bambulskaya. "Precision medicine and inflammatory bowel diseases: concept, strategies, future." Experimental and Clinical Gastroenterology 1, no. 6 (2021): 121–29. http://dx.doi.org/10.31146/1682-8658-ecg-190-6-121-129.

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With the advent of modern cellular and genomic technologies, we have become participants in the integration of such areas as personalized, predictive, preventive, and precision medicine (referred to as 4P-medicine), into practical healthcare. In replace of the classic methods of diagnosis and treatment of diseases comes medicine, which makes it possible to predict (anticipate) the disease, and a personalized approach to each patient, taking into account their genetic, biochemical and physiological uniqueness. Precision medicine aims to improve the quality of medical care by opening up an indiv

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SHCHERBAK, Svitlana. "MODERNIZATION CONCEPT AND SOCIAL IMAGINATION: METHODOLOGICAL NOTES." Filosofska dumka (Philosophical Thought) -, no. 4 (2023): 56–70. http://dx.doi.org/10.15407/fd2023.04.056.

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Since its inception, the theory of modernization has undergone so many transformations that it makes sense to speak of a «modernization discourse» rather than a theory and to consider the concept itself from the point of view of social epistemology in conjunction with social imagination. This paper is devoted to substantiating this approach. The concept of modernization is interesting in this regard because it contains not only hermeneutic but also prescriptive elements: by placing society in a broader historical framework of past, present and future, it creates a normative horizon for self-un

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Gołąbek, Agata, Katarzyna Kowalska, and Anna Olejnik. "Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives." Nutrients 13, no. 4 (2021): 1347. http://dx.doi.org/10.3390/nu13041347.

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Endometriosis represents an often painful, estrogen-dependent gynecological disorder, defined by the existence of endometrial glands and stroma exterior to the uterine cavity. The disease provides a wide range of symptoms and affects women’s quality of life and reproductive functions. Despite research efforts and extensive investigations, this disease’s pathogenesis and molecular basis remain unclear. Conventional endometriosis treatment implies surgical resection, hormonal therapies, and treatment with nonsteroidal anti-inflammatory drugs, but their efficacy is currently limited due to many s

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Torregrossa, Fabio, and Giovanni Grasso. "Concept of Spectrobiopsy Facing Gliomas: Rational and Future Perspectives Related to Target Therapy." World Neurosurgery 134 (February 2020): 308–10. http://dx.doi.org/10.1016/j.wneu.2019.11.020.

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Murray-Mendes, Savannah, Anastasia Raquel Martinez, and Katie L. Hackett. "Identifying Occupational Therapy Research Priorities in Trinidad and Tobago: A Group Concept Mapping Study." Occupational Therapy International 2021 (October 12, 2021): 1–13. http://dx.doi.org/10.1155/2021/9970566.

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In Trinidad and Tobago, occupational therapy is an emerging profession with limitations in the number of practitioners and the scope of practice. With the development of a new Master of Science Occupational Therapy programme in the country, the profession is continuously growing. There has been an increased demand for culturally relevant research to build the occupational therapy evidence base locally. However, the narrow range of occupational therapy literature in the country makes it difficult to highlight research gaps and decipher what research areas should be prioritised to best impact oc

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Mc Hugh, Conor. "Orthoses: Basic science, myths and future direction." Physiotherapy Practice and Research 42, no. 1 (2021): 3–5. http://dx.doi.org/10.3233/ppr-219002.

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The mechanisms by which orthoses work has been poorly understood despite the widespread use of orthoses in the physiotherapy and podiatry professions. This lack of clarity has been largely fuelled by methodological flaws in the literature, namely, approaching orthoses in a comparative manner to itself and/or other interventions. Future research would be best served by returning to physics first principles. The ‘kinetic dose’ concept is an approach worthy of further exploration.

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Alcala-Gonzalez, Joel Isai, Adrian Camacho-Ortiz, Marco Antonio Hernandez-Guedea, Laura Marina Nuzzolo-Shihadeh, Luis Adrian Salinas-Garza, and Eduardo Perez-Alba. "Instant messaging for outpatient intramuscular antibiotic therapy adherence: proof of concept." Journal of Infection in Developing Countries 18, no. 11 (2024): 1721–25. https://doi.org/10.3855/jidc.19345.

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Objective: Outpatient antimicrobial therapy works but often requires in-person oversight. Advancements enable seamless communication. We used instant messaging to track adherence, cost, efficacy, and adverse events for outpatient intramuscular antibiotic therapy. Material and methods: We invited eligible inpatients with bacterial isolates susceptible to ceftriaxone, cefepime, ceftazidime, meropenem, or ertapenem and a positive clinical response to infection to join the study. Participants received antibiotics and submitted daily photos of the used vial through an instant messaging application.

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Testori, Alessandro A. E., Silvia Chiellino, and Alexander C. J. van Akkooi. "Adjuvant Therapy for Melanoma: Past, Current, and Future Developments." Cancers 12, no. 7 (2020): 1994. http://dx.doi.org/10.3390/cancers12071994.

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This review describes the progress that the concept of adjuvant therapies has undergone in the last 50 years and focuses on the most recent development where an adjuvant approach has been scientifically evaluated in melanoma clinical trials. Over the past decade the development of immunotherapies and targeted therapies has drastically changed the treatment of stage IV melanoma patients. These successes led to trials studying the same therapies in the adjuvant setting, in high risk resected stage III and IV melanoma patients. Adjuvant immune checkpoint blockade with anti-CTLA-4 antibody ipilimu

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Young, Shamar, Jack Hannallah, Dan Goldberg, et al. "Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions." Seminars in Interventional Radiology 40, no. 06 (2023): 515–23. http://dx.doi.org/10.1055/s-0043-1777711.

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AbstractIn the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at the same time. One of the areas where this can be clearly seen is the concomitant use of locoregional and systemic therapies in patients with primary or secondary cancers of the liver. These combined algorithms have gained favor over the last decade and are largely focused on the allure of the combined ability to control systemic diseas

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Kuznietsova, Oksana. "ESSENCE AND FEATURES OF THE CONCEPT “COMMUNICATIVE COMPETENCE OF FUTURE TEACHERS OF SPEECH THERAPY GROUPS”." Collection of Scientific Papers of Uman State Pedagogical University, no. 3 (October 12, 2021): 108–17. http://dx.doi.org/10.31499/2307-4906.3.2021.241750.

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The article investigates the essence of the concept of “communicative competence of the teacher of speech therapy groups” and defines its components. The content of the notions “competence”, “professional competence”, “communicative competence”, and “communicative competence of the teacher of the preschool institution of compensatory type” is revealed. The author defines the communicative competence of the future educator of speech therapy groups as a tool of correctional and pedagogical action. It is characterized by the unity of communicative skills, knowledge, skills, which include: speech

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SPISAK, JAN. "HYBRID THREATS AND THE DEVELOPMENT OF THE NEW NATO OVERARCHING CONCEPT." CONTEMPORARY MILITARY CHALLENGES 2011, no. 13/3 (2011): 11–19. http://dx.doi.org/10.33179/bsv.99.svi.11.cmc.13.3.1.

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This article deals with aspects of newly emerging security challenges that military theoreticians and authors of security and defense strategic documents name ‘Hybrid Threats’. They currently present a significant challenge for the Alliance and its interests. Hybrid Threats involve adversaries (including states, rogue states, non-state actors or terrorist organizations) that may employ a combination of actions in an increasingly unconstrained operating environment in order to achieve their aims. Hybrid Threats may consist of a combination of every aspect of warfare and compound the activities

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Knödler, L. L., A. Thomann, M. P. Ebert, S. Lis, and W. Reindl. "P470 The concept of illness identity in inflammatory bowel disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S414—S415. http://dx.doi.org/10.1093/ecco-jcc/jjz203.599.

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Abstract Background Chronic diseases like inflammatory bowel diseases (IBD) can pose challenges to the self-concept of a patient. Illness identity (IID) describes a patient′s way to integrate a chronic illness into the self-concept distinguishing the dimensions rejection, engulfment, acceptance and enrichment. Associations between IID and psychological and physiological functioning have been shown in other chronic diseases, but haven’t been investigated in IBD. In this study, we focus on associations between IID and (i) psychosomatic well-being and (ii) response to biological therapy in patien

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van der Walle, Christopher F., Christine Dufès, Arpan S. Desai, et al. "Report on Webinar Series Cell and Gene Therapy: From Concept to Clinical Use." Pharmaceutics 14, no. 1 (2022): 168. http://dx.doi.org/10.3390/pharmaceutics14010168.

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With the launch of the UK Academy of Pharmaceutical Sciences Advanced Therapy Medicinal Products Focus Group in late 2020, a webinar series reviewing the current and emerging trends in cell and gene therapy was held virtually in May 2021. This webinar series was timely given the recent withdrawal of the United Kingdom from the European Union and the global COVID-19 pandemic impacting all sectors of the pharmaceutical sciences research landscape globally and in the UK. Delegates from the academic, industry, regulatory and NHS sectors attended the session where challenges and opportunities in th

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Akbar, Sheikh Mohammad Fazle, Mamun Al Mahtab, Sakirul Khan, Osamu Yoshida, and Yoichi Hiasa. "Development of Therapeutic Vaccine for Chronic Hepatitis B: Concept, Cellular and Molecular Events, Design, Limitation, and Future Projection." Vaccines 10, no. 10 (2022): 1644. http://dx.doi.org/10.3390/vaccines10101644.

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Four decades have passed since the first usage of the therapeutic vaccine in patients with chronic hepatitis B (CHB). However, there is no approved regimen of vaccine therapy for the treatment of CHB. This is mainly attributable to faulty conception, an improper understanding of the cellular and molecular mechanisms of CHB, and the impaired design of vaccine therapy for CHB. With the advent of new techniques and a better understanding of cellular and molecular mechanisms underlying the genesis of CHB, the limitations and failures of previous regimens of therapeutic vaccines have been primarily

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Bamboulis, Chloe. "Core Beliefs in Cognitive Behavioral Therapy and Stoicism." Philosophy, Psychiatry, & Psychology 32, no. 2 (2025): 163–77. https://doi.org/10.1353/ppp.2025.a964183.

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Abstract: Despite academic interest in the overall comparison of cognitive behavioral therapy with Stoicism, the notion of core beliefs is often neglected in the literature. In this paper, I address this by examining ethical concepts in Stoicism which are comparable to core beliefs in cognitive behavioral therapy. The first relevant concept is prolepseis , which is dispositions to form judgments. The second one is hexeis , used to describe interpretational and emotional tendencies. These are similar to core beliefs in various ways, including: 1) They are based on innate and environmental facto

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Richards, Sheelagh E. "Community Occupational Therapy: Past Dreams and New Visions." British Journal of Occupational Therapy 55, no. 7 (1992): 257–59. http://dx.doi.org/10.1177/030802269205500704.

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The traditional concept of community occupational therapy services, located in local authorities and developing to meet the needs of the broad range of social services' client groups, is being challenged by the NHS and community care reforms. This article reflects on past aspirations, considers emerging trends and invites community occupational therapists to participate more fully in developing the profession's views on its future.

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Ulrich, Dale A., and Douglas H. Collier. "Perceived Physical Competence in Children with Mental Retardation: Modification of a Pictorial Scale." Adapted Physical Activity Quarterly 7, no. 4 (1990): 338–54. http://dx.doi.org/10.1123/apaq.7.4.338.

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Self-perceptions of competence are thought to mediate a person’s motivation to participate and persist in tasks under optimally challenging conditions. Little systematic research has been conducted related to the self-perceptions of physical competence in children with mental retardation and the influence on achievement motivation in this domain. Various models of self-concept are reviewed, followed by a discussion of self-concept and special populations. Preliminary data are presented on a modified pictorial scale of perceived physical competence for use with 7- to 12-year-old students with m

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Furukawa, Yoshiki, Yasuharu Hamano, Shuichi Shirane, et al. "Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on “Off-the-Shelf” T Cell Therapy Using iPSC Technology and Gene Editing." Cells 11, no. 2 (2022): 269. http://dx.doi.org/10.3390/cells11020269.

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The concept of allogeneic cell therapy was first presented over 60 years ago with hematopoietic stem cell transplantation. However, complications such as graft versus host disease (GVHD) and regimen-related toxicities remained as major obstacles. To maximize the effect of graft versus leukemia, while minimizing the effect of GVHD, donor lymphocyte infusion was utilized. This idea, which was used against viral infections, postulated that adoptive transfer of virus-specific cytotoxic T lymphocytes could reconstitute specific immunity and eliminate virus infected cells and led to the idea of bank

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Kvitka, D. M., V. O. Palamarchuk, S. V. Zemskov, and R. M. Sichinava. "Introduction of the quality of life concept in practical medicine." Clinical Endocrinology and Endocrine Surgery, no. 1 (December 6, 2021): 70–75. http://dx.doi.org/10.30978/cees-2021-1-70.

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The modern stage of medical development requires a multidisciplinary approach to studying the impact of treatment on human life. The social aspects are of great importance because the goal of treatment is to preserve or/and improve life. Therefore, the term "quality of life" is increasingly used in the world medical literature. The objectification of this indicator and its adaptation in practical medicine is a priority task. The concept of "quality of life" first appeared in 1958. In the future, this concept was developed in a research carried out by a group of professors at MIT (Massachusetts

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Howarth, Graham R. "Futility-caveat lector." South African Family Practice 45, no. 8 (2003): 2. http://dx.doi.org/10.4102/safp.v45i8.1887.

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In some ways, those persons who practise medicine have become of its victims. We wish to do the best for our patients. However, occasionally the advantages of the treatment may be marginal. Added to this is the spiraling cost of the medical therapy, something that doctors are aware of. To make the problem even more difficult, we have increasing awareness by patients and their families of the concepts of autonomy and patient's rights. They feel that they can demand treatment that the doctor may feel is of no or marginal benefit; possibly also at great expense. This card in these situations, tha

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Savin-Baden, Maggi. "Problem-Based Learning, Part 3: Making Sense of and Managing Disjunction." British Journal of Occupational Therapy 61, no. 1 (1998): 13–16. http://dx.doi.org/10.1177/030802269806100104.

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This is the third of three papers which explores the growing influence of problem-based learning (PBL) within professional curricula. Part 1 documented the emergence of PBL in a climate of world-wide change. Part 2 presented the model of Dimensions of Learner Experience and argued that it offers a framework for broadening current understandings of learner experience on diverse PBL programmes. Part 3 discusses the findings of the study, which extend earlier work around the concept of disjunction in learning, and the notion of enabling and disabling forms in relation to three different understan

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Avdeev, S. N., I. V. Leshchenko, and Z. R. Aisanov. "New concept and algorithm for the management of patients with chronic obstructive pulmonary disease." PULMONOLOGIYA 33, no. 5 (2023): 587–94. http://dx.doi.org/10.18093/0869-0189-2023-33-5-587-594.

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Currently, chronic obstructive pulmonary disease (COPD) is a global problem and one of the leading causes of death worldwide. COPD therapy includes pharmacological and non-pharmacological approaches that can significantly reduce clinical symptoms and decrease the frequency of exacerbations of the disease. Methods. The updates of guidelines for the diagnosis and treatment of COPD is expected to have a significant impact on patients with COPD in clinical practice. Simplification of the treatment algorithms and inclusion of triple therapy will help clinicians provide appropriate and timely treatm

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García- Montero Blanco, C. "Advances in Xenotransplantation, 3D Additive Bioprinting and Gene Therapy for the future of Heart Transplantation." ANALES RANM 140, no. 140(02) (2023): 170–84. http://dx.doi.org/10.32440/ar.2023.140.02.rev06.

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Heart transplantation (HTx) has proved itself to be the definite therapy for patients with end- stage cardiac failure. While HTx remains the cornerstone of the surgical armamentarium, it,s long- term success has resulted in an unbalanced supply- demand equation due to severe scarcity of valid organ donors. Therefore, further developments in the field of transplant therapy remain curtailed, unless other resources are encouraged. The present report is a review on the concept evolution, present status and reasonable outlook of three different, but confluent, emerging therapies, namely, a) xenotra

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