Books on the topic 'Condition de bonne formation'

The textbook introduces the history of the formation of the institute of bankruptcy, conducting reorganization and liquidation procedures in a crisis, diagnosing the financial condition of an enterprise based on situational and coefficient analysis, multiplicative factor models for assessing the threat of bankruptcy, methods for assessing the value of an insolvent enterprise, as well as accounting for operations related to bankruptcy procedures. The possibilities of an integrated approach to the development of a strategy for overcoming the crisis and choosing ways to restructure a bankrupt enterprise are considered. Meets the requirements of the federal state educational standards of higher education of the latest generation. For teachers, postgraduates and students of higher educational organizations, employees of analytical services, anti-crisis managers.

The topics of work flexibility, precarious jobs, and the relationship between work, the market and production are subjects that are widely debated in the sociological, philosophical, economic and political spheres. Yet these topics are less touched on in the tradition of pedagogical research. The intention of this book is to build a seedbed for reflection on the central position assumed by work in the lives of every woman and man, inhabitants of a planet in which the transformation of work activities is imposing radical changes on lifestyles, community-building and societies. Work is not an abstract concept, but is incorporated into every human person who does it and into the relationships linking them to others. Man, his education and human formation provide the pivot around which to perform a pedagogical survey within the universe of "work", and inside the relationship between the human condition and working/professional life. What sense does work acquire today when going to observe children, young people, adults or migrants? Namely, what sense does it assume when its pivotal viewpoint is shifted off-centre in time and space? The essays intend to spark agile but critical, synchronic and diachronic reflection which, stemming from contextual questions on the meaning of work and on change in the workplace, will proceed to investigate the subjects in their specific lives and existential conditions. Essays by: Vanna Boffo, Pietro Causarano, Giovanna Del Gobbo, Emiliano Macinai, Maria Rita Mancaniello, Stefano Oliviero and Clara Silva.

The textbook systematizes basic knowledge in the field of finance, financial analysis and financial management, presented in their direct relationship and significance from the point of view of evaluation, diagnosis, forecasting and monitoring of the continuity of the organization's activities. It includes seven chapters grouped into three sections. The first section is devoted to the theoretical foundations of the organization's financial management, stakeholders and sources of the organization's activities. The second section discusses the basics of financial analysis, providing knowledge of the main directions, information base and methods of financial analysis, as well as allowing them to be applied reasonably, calculate and evaluate analytical indicators, determine the impact of globalization processes, various macro-and microfactors on the financial condition of the organization. The third section contains the basics of financial management, providing an understanding of the essence of the financial mechanism of the organization and algorithms for justifying decisions in the field of financial management. It complies with the federal state educational standards of higher education of the latest generation and provides the formation of basic competencies in the field of finance, financial management and financial analysis. For bachelor's, specialist's and master's students studying in the field of Economics, the system of additional professional education, training centers for advanced training of auditors and other financial market specialists, as well as for individual preparation of applicants for qualification certification and passing qualification exams.

Osteoarthritis (OA) is the commonest condition to affect synovial joints, but although any synovial joint can be affected, most studies of pathology relate to large joints (knees and hips). OA involves the whole joint and pathological alterations typically occur in all joint tissues. Established OA is characterized by a mixture of tissue loss and new tissue production resulting in focal loss of articular hyaline cartilage together with bone remodelling and osteophyte formation. Articular cartilage may show increased thickness in the earliest stages of OA with increased numbers of hypertrophic chondrocytes, followed by progressive decline in matrix components, thickness, and chondrocyte number. Surface fibrillation and vertical clefts become evident in mid- to end-stage OA and eventual complete loss of cartilage can occur, predominantly in maximum load-bearing regions, with subsequent eburnation and furrowing of bone. Bone remodelling may lead to alteration of bone shape and variable trabecular thickness in subchondral bone, whilst subchondral microfractures may result in localized osteonecrosis, fibrosis, and ‘cysts’. Endochondral ossification of new fibrocartilage produced predominantly at the joint margin produces characteristic bony osteophytes. The synovium shows areas of hyperplasia with varying amounts of lymphocyte aggregates and inclusion of osteochondral ‘loose’ bodies, and the outer fibrous capsule thickens to help stabilize the compromised joint. Synovial fluid increases in volume but decreases in viscosity. Periarticular changes include type II muscle atrophy and enthesophytes.

Genetic conditions affecting the skeleton and supporting structures are individually rare and heterogeneous. This chapter presents an approach to assessing patients with suspected skeletal dysplasia, osteogenesis imperfecta, Marfan syndrome, and Ehlers–Danlos syndrome. Skeletal dysplasias are caused by abnormalities of bone growth and modelling; the commonest non-lethal type is achondroplasia, with an incidence of 1/10 000 to 1/30 000. The typical presentation of osteogenesis imperfecta is with multiple fractures, sometimes prenatally. There may be associated short stature, bone deformity, dentogenesis imperfecta, blue sclera, and hearing loss. Most patients with osteogenesis imperfecta have mutations in COL1A1 or COL1A2. Marfan syndrome is a connective tissue disease with a pattern of symptoms related to the presence of fibrillin in tissues. Typically, affected individuals are of tall, thin stature, with long fingers and toes (arachnodactyly), a pectus deformity, and scoliosis. Between 66% and 91% of individuals with Marfan syndrome have a mutation in fibrillin-1 (FBN1; locus: 15q21). All forms of Ehlers–Danlos syndrome present with variable thinning and fragility of skin, leading to easy bruising and poor scar formation. There is skin and joint laxity. In severe forms, blood vessels and internal organs are affected.

Palaeopathology is the study of disease in the past. Various different types of data can be used, including literature, paintings, and sculpture. In addition, for the rheumatic diseases, skeletal remains offer a particularly rich source of information for the palaeopathologist. This chapter only discusses the skeletal palaeopathology of osteoarthritis (OA). OA leaves characteristic imprints on the skeleton, such as osteophytes and bony sclerosis, which survive death, burial, and the recovery of skeletons. This has allowed researchers to compare the prevalence and distribution of OA within and between joints in skeletal collections obtained from different ancient populations in various countries. The data have shown that while OA has been common in all human populations studied, the nature, prevalence, and intra-articular distribution of the disease in different joints have probably changed over time. A high prevalence of elbow OA has been observed in many collections of human skeletons, suggesting that this joint may be more prone to the disease than generally thought, but that it might remain asymptomatic in the majority of people affected. In addition, skeletal palaeopathologists have found an association between osteophyte formation and enthesophytes, suggesting that some people may have a predisposition to osteoarticular changes characterized by new bone formation. OA has also been described and studied in different primate and other animal skeletons, providing further fascinating insights into the condition.

Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones are a tissue that even in adult life retains the ability to change shape and structure depending on changes in their mechanical and hormonal environment, as well as self-renewal and repair capabilities. This process is called bone turnover. The basic processes of bone turnover are: • bone modeling (incessantly changes in bone shape during individual growth) following resorption and tissue formation at various locations (e.g. bone marrow formation) to increase mass and skeletal morphology. This process occurs in the bones of growing individuals and stops after reaching puberty • bone remodeling (processes involve in maintaining bone tissue by resorbing and replacing old bone tissue with new tissue in the same place, e.g. repairing micro fractures). It is a process involving the removal and internal remodeling of existing bone and is responsible for maintaining tissue mass and architecture of mature bones. Bone turnover is regulated by two types of transformation: • osteoclastogenesis, i.e. formation of cells responsible for bone resorption • osteoblastogenesis, i.e. formation of cells responsible for bone formation (bone matrix synthesis and mineralization) Bone maturity can be defined as the completion of basic structural development and mineralization leading to maximum mass and optimal mechanical strength. The highest rate of increase in pig bone mass is observed in the first twelve weeks after birth. This period of growth is considered crucial for optimizing the growth of the skeleton of pigs, because the degree of bone mineralization in later life stages (adulthood) depends largely on the amount of bone minerals accumulated in the early stages of their growth. The development of the technique allows to determine the condition of the skeletal system (or individual bones) in living animals by methods used in human medicine, or after their slaughter. For in vivo determination of bone properties, Abstract 10 double energy X-ray absorptiometry or computed tomography scanning techniques are used. Both methods allow the quantification of mineral content and bone mineral density. The most important property from a practical point of view is the bone’s bending strength, which is directly determined by the maximum bending force. The most important factors affecting bone strength are: • age (growth period), • gender and the associated hormonal balance, • genotype and modification of genes responsible for bone growth • chemical composition of the body (protein and fat content, and the proportion between these components), • physical activity and related bone load, • nutritional factors: – protein intake influencing synthesis of organic matrix of bone, – content of minerals in the feed (CA, P, Zn, Ca/P, Mg, Mn, Na, Cl, K, Cu ratio) influencing synthesis of the inorganic matrix of bone, – mineral/protein ratio in the diet (Ca/protein, P/protein, Zn/protein) – feed energy concentration, – energy source (content of saturated fatty acids - SFA, content of polyun saturated fatty acids - PUFA, in particular ALA, EPA, DPA, DHA), – feed additives, in particular: enzymes (e.g. phytase releasing of minerals bounded in phytin complexes), probiotics and prebiotics (e.g. inulin improving the function of the digestive tract by increasing absorption of nutrients), – vitamin content that regulate metabolism and biochemical changes occurring in bone tissue (e.g. vitamin D3, B6, C and K). This study was based on the results of research experiments from available literature, and studies on growing pigs carried out at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences. The tests were performed in total on 300 pigs of Duroc, Pietrain, Puławska breeds, line 990 and hybrids (Great White × Duroc, Great White × Landrace), PIC pigs, slaughtered at different body weight during the growth period from 15 to 130 kg. Bones for biomechanical tests were collected after slaughter from each pig. Their length, mass and volume were determined. Based on these measurements, the specific weight (density, g/cm3) was calculated. Then each bone was cut in the middle of the shaft and the outer and inner diameters were measured both horizontally and vertically. Based on these measurements, the following indicators were calculated: • cortical thickness, • cortical surface, • cortical index. Abstract 11 Bone strength was tested by a three-point bending test. The obtained data enabled the determination of: • bending force (the magnitude of the maximum force at which disintegration and disruption of bone structure occurs), • strength (the amount of maximum force needed to break/crack of bone), • stiffness (quotient of the force acting on the bone and the amount of displacement occurring under the influence of this force). Investigation of changes in physical and biomechanical features of bones during growth was performed on pigs of the synthetic 990 line growing from 15 to 130 kg body weight. The animals were slaughtered successively at a body weight of 15, 30, 40, 50, 70, 90, 110 and 130 kg. After slaughter, the following bones were separated from the right half-carcass: humerus, 3rd and 4th metatarsal bone, femur, tibia and fibula as well as 3rd and 4th metatarsal bone. The features of bones were determined using methods described in the methodology. Describing bone growth with the Gompertz equation, it was found that the earliest slowdown of bone growth curve was observed for metacarpal and metatarsal bones. This means that these bones matured the most quickly. The established data also indicate that the rib is the slowest maturing bone. The femur, humerus, tibia and fibula were between the values of these features for the metatarsal, metacarpal and rib bones. The rate of increase in bone mass and length differed significantly between the examined bones, but in all cases it was lower (coefficient b <1) than the growth rate of the whole body of the animal. The fastest growth rate was estimated for the rib mass (coefficient b = 0.93). Among the long bones, the humerus (coefficient b = 0.81) was characterized by the fastest rate of weight gain, however femur the smallest (coefficient b = 0.71). The lowest rate of bone mass increase was observed in the foot bones, with the metacarpal bones having a slightly higher value of coefficient b than the metatarsal bones (0.67 vs 0.62). The third bone had a lower growth rate than the fourth bone, regardless of whether they were metatarsal or metacarpal. The value of the bending force increased as the animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. The rate of change in the value of this indicator increased at a similar rate as the body weight changes of the animals in the case of the fibula and the fourth metacarpal bone (b value = 0.98), and more slowly in the case of the metatarsal bone, the third metacarpal bone, and the tibia bone (values of the b ratio 0.81–0.85), and the slowest femur, humerus and rib (value of b = 0.60–0.66). Bone stiffness increased as animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. Abstract 12 The rate of change in the value of this indicator changed at a faster rate than the increase in weight of pigs in the case of metacarpal and metatarsal bones (coefficient b = 1.01–1.22), slightly slower in the case of fibula (coefficient b = 0.92), definitely slower in the case of the tibia (b = 0.73), ribs (b = 0.66), femur (b = 0.59) and humerus (b = 0.50). Bone strength increased as animals grew. Regardless of the growth point tested, bone strength was as follows femur > tibia > humerus > 4 metacarpal> 3 metacarpal> 3 metatarsal > 4 metatarsal > rib> fibula. The rate of increase in strength of all examined bones was greater than the rate of weight gain of pigs (value of the coefficient b = 2.04–3.26). As the animals grew, the bone density increased. However, the growth rate of this indicator for the majority of bones was slower than the rate of weight gain (the value of the coefficient b ranged from 0.37 – humerus to 0.84 – fibula). The exception was the rib, whose density increased at a similar pace increasing the body weight of animals (value of the coefficient b = 0.97). The study on the influence of the breed and the feeding intensity on bone characteristics (physical and biomechanical) was performed on pigs of the breeds Duroc, Pietrain, and synthetic 990 during a growth period of 15 to 70 kg body weight. Animals were fed ad libitum or dosed system. After slaughter at a body weight of 70 kg, three bones were taken from the right half-carcass: femur, three metatarsal, and three metacarpal and subjected to the determinations described in the methodology. The weight of bones of animals fed aa libitum was significantly lower than in pigs fed restrictively All bones of Duroc breed were significantly heavier and longer than Pietrain and 990 pig bones. The average values of bending force for the examined bones took the following order: III metatarsal bone (63.5 kg) <III metacarpal bone (77.9 kg) <femur (271.5 kg). The feeding system and breed of pigs had no significant effect on the value of this indicator. The average values of the bones strength took the following order: III metatarsal bone (92.6 kg) <III metacarpal (107.2 kg) <femur (353.1 kg). Feeding intensity and breed of animals had no significant effect on the value of this feature of the bones tested. The average bone density took the following order: femur (1.23 g/cm3) <III metatarsal bone (1.26 g/cm3) <III metacarpal bone (1.34 g / cm3). The density of bones of animals fed aa libitum was higher (P<0.01) than in animals fed with a dosing system. The density of examined bones within the breeds took the following order: Pietrain race> line 990> Duroc race. The differences between the “extreme” breeds were: 7.2% (III metatarsal bone), 8.3% (III metacarpal bone), 8.4% (femur). Abstract 13 The average bone stiffness took the following order: III metatarsal bone (35.1 kg/mm) <III metacarpus (41.5 kg/mm) <femur (60.5 kg/mm). This indicator did not differ between the groups of pigs fed at different intensity, except for the metacarpal bone, which was more stiffer in pigs fed aa libitum (P<0.05). The femur of animals fed ad libitum showed a tendency (P<0.09) to be more stiffer and a force of 4.5 kg required for its displacement by 1 mm. Breed differences in stiffness were found for the femur (P <0.05) and III metacarpal bone (P <0.05). For femur, the highest value of this indicator was found in Pietrain pigs (64.5 kg/mm), lower in pigs of 990 line (61.6 kg/mm) and the lowest in Duroc pigs (55.3 kg/mm). In turn, the 3rd metacarpal bone of Duroc and Pietrain pigs had similar stiffness (39.0 and 40.0 kg/mm respectively) and was smaller than that of line 990 pigs (45.4 kg/mm). The thickness of the cortical bone layer took the following order: III metatarsal bone (2.25 mm) <III metacarpal bone (2.41 mm) <femur (5.12 mm). The feeding system did not affect this indicator. Breed differences (P <0.05) for this trait were found only for the femur bone: Duroc (5.42 mm)> line 990 (5.13 mm)> Pietrain (4.81 mm). The cross sectional area of the examined bones was arranged in the following order: III metatarsal bone (84 mm2) <III metacarpal bone (90 mm2) <femur (286 mm2). The feeding system had no effect on the value of this bone trait, with the exception of the femur, which in animals fed the dosing system was 4.7% higher (P<0.05) than in pigs fed ad libitum. Breed differences (P<0.01) in the coross sectional area were found only in femur and III metatarsal bone. The value of this indicator was the highest in Duroc pigs, lower in 990 animals and the lowest in Pietrain pigs. The cortical index of individual bones was in the following order: III metatarsal bone (31.86) <III metacarpal bone (33.86) <femur (44.75). However, its value did not significantly depend on the intensity of feeding or the breed of pigs.

Eva, une « sans-ami » sur les réseaux sociaux, André, salarié « restructuré » après trente ans passés dans l’industrie chimique, Louis, sans emploi, cherchant à prouver sa « bonne volonté » à l’aide sociale, Nadia, jeune femme infibulée confrontée au système médical suisse… Comment ces personnes vivent-elles ces vies sous contrainte ? Que font-elles face aux dispositifs institutionnels ou aux liens sociaux qui les privent d’une partie de leur liberté d’être ou de faire ce qu’elles souhaitent ? Les situations de domination ordinaire sont peu visibles dans l’espace public suisse. Nos recherches permettent de montrer que, bien loin d’être silencieux et passifs, les « dominés » mettent en place des moyens d’agir originaux. Ainsi en est-il des personnes séropositives usant du secret pour échapper à l’opprobre, des étrangers négociant et détournant les noms dont on les affuble ou encore des femmes dépendantes économiquement gagnant par un travail empathique auprès de leur mari des plages d’autonomie personnelle. Même sous contrainte, ils agissent et s’aménagent des marges de manoeuvre. Ces figures de l’action sous domination ou de dominaction, comme nous les avons appelées, représentent ainsi une énigme aujourd’hui, dans un monde où les formes de pouvoir sont de plus en plus désincarnées et où la distribution de la considération sociale, de la réputation ou de la reconnaissance constitue un enjeu central de nos sociétés.

Augustine’s dominant image for the human life is peregrinatio, which signifies at once a journey to the homeland—a pilgrimage—and the condition of exile from the homeland. For Augustine, all human beings are, in the earthly life, exiles from their true homeland: heaven. Only some become pilgrims seeking a way back to the heavenly homeland, a return mediated by the incarnate Christ. Becoming a pilgrim begins with attraction to beauty. The return journey therefore involves formation, both moral and aesthetic, in loving rightly. This image has occasioned a lot of angst in ethical thought in the last century or so. Augustine’s vision of Christian life as a pilgrimage, his critics allege, casts a pall of groaning and longing over this life in favor of happiness in the next. Augustine’s eschatological orientation robs the world of beauty and ethics of urgency. In this book, Stewart-Kroeker sets out to elaborate Augustine’s understanding of moral and aesthetic formation via the pilgrimage image, which she argues reflects a Christological continuity between the earthly journey and the eschatological home that unites love of God and neighbor. From the human desire for beauty to the embodied practice of Christian sacraments, Stewart-Kroeker reveals the integrity of Augustine’s vision of moral and aesthetic formation, which is essentially the ordering of love. Along the way, Stewart-Kroeker develops an Augustinian account of the relationship between beauty and morality.

Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids. Only about 1% of total body Pi content is present in extracellular fluids, at a plasma concentration in adults within the range 0.8–1.4 mMol/L (at pH 7.4 mostly as HPO42−), with diurnal variations of approximately 0.2 mM. A small amount of plasma Pi is bound to proteins or forms complexes with calcium. Under normal, balanced conditions, absorption of dietary Pi along the small intestine equals the output of Pi via kidney and faeces. Renal excretion of Pi represents the key determinant for the adjustment of normal Pi plasma concentrations. Renal reabsorption of Pi occurs along the proximal tubules by sodium-dependent Pi cotransporters that are strictly localized at the apical brush border membrane. Parathyroid hormone (PTH) and FGF23 are key regulators amongst a myriad of factors controlling excretion of Pi in urine, mostly by changes of the apical abundance of Na/Pi cotransporters. Hypophosphataemia may result in osteomalacia, rickets, muscle weakness, and haemolysis. Hyperphosphataemia can lead to hyperparathyroidism and severe calcifications in different tissues.

Présenter le titre de ce numéro dans une forme interrogative, c'est d'emblée questionner les paradigmes, théories et modèles qui sous-tendent la notion de santé au travail et plus encore de ses liens avec l'éducation et la formation, domaine à interroger aussi. Le projet est né des journées internationales et interdisciplinaires « Towards a Feasible New Economy of Innovative and Healthy Work » organisées à Bordeaux les 28-29 avril 2016 par Loïc Lerouge, Directeur de recherche au CNRS, spécialiste de droit de la santé au travail (CNRS, Bordeaux) et Robert Karasek, professeur émérite en psychosociologie de l'Université du Massachusetts Lowell et de l'Université de Copenhague. Cet événement a marqué un tournant dans la manière d'appréhender la santé au travail en mettant en discussion les développements de l'économie au regard de l'innovation et de la protection de la santé au travail. Le groupe d'experts scientifiques international et pluridisciplinaire qui a été réuni a dégagé neuf sujets et questions qui ont été ensuite confrontés aux acteurs du monde socio-économique (parties-prenantes). Le sujet de l'éducation à la santé au travail y figurait en bonne place et les conclusions finales ont notamment insisté sur la nécessité de développer l'approche éducative de la santé et de la sécurité au travail.

Ciliopathies encompass a genotypically complex and phenotypically variable and overlapping series of disorders that makes the general term ‘ciliopathies’ very useful. The genes behind these conditions encode parts of the machinery of the primary cilium. This is also true of the major cystic kidney disorders autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease, but the ‘long tails’ of other ciliopathies are characterized by variable nephropathy (often without cyst formation), retinopathy, and effects on brain and skeletal development. Not all have substantial renal phenotypes. Bardet–Biedl syndrome (BBS) is an autosomal dominant condition characterized by obesity, retinopathy, nephropathy, and learning difficulty, but renal abnormalities are varied and end-stage renal failure occurs in only a minority. Many BBS genes have been described. Alström syndrome is a rare recessive disorder again associated with obesity and retinopathy, but also deafness and dilated cardiomyopathy. Renal failure is a common but later feature. Joubert syndrome is an autosomal dominant condition but can arise from mutations in at least 10 genes. It has a wide phenotypic variation with a common link being hypodysplasia of the cerebellar vermis and other abnormalities giving rise to the ‘molar tooth sign’ on cerebral magnetic resonance imaging scanning, associated with hypotonia in infancy, central ataxia, ocular apraxia, developmental delay, and varying degrees of cognitive impairment. Jeune syndrome is a recessive condition characterized by osteochondrodysplasia which can give rise to hypodevelopment of the chest wall known as suffocating thoracic dystrophy, in addition to other manifestations.

Immunoglobulin A (IgA)-dominant post-infectious glomerulonephritis is usually associated with infections with Staphylococcus aureus. It is most commonly seen in patients over 60, and particularly in men. The renal lesion is acute and severe, and commonly includes crescent formation, although the described histological features vary widely. IgA is the dominant immunoglobulin and in later phases when capillary deposits are resolving it may be impossible to distinguish the condition from IgA nephropathy without the use of electron microscopy. Diabetes appears to be a risk factor. Complement levels are frequently low but may be normal. Clinically there is often severe nephrotic syndrome and hypertension may be less prominent.

Archaeologists, historians, and geographers link Hispano or vecino ethnogenesis in the late eighteenth century to the occupation of a land base, while at the heart of modern Nuevomexicano identity formation is the paradoxical condition of being simultaneously dispossessed and place-based. The modern Hispano ethnoscape combines themes of land loss, displacement, and a deep longing to remain on the land, captured by the term querencia, which refers both to place and love of place. The social imaginary of a commons is central to contemporary land grant and acequia activists—long lost to land grant heirs, but still operative as a principle of water governance among community irrigation associations. Access to and control over a water source remains a key feature of Hispano as well as Pueblo traditional adaptations and modern place-based identities.

Cervical spinal stenosis is the narrowing of the spinal canal. Degenerative cervical spinal stenosis can occur as a result of disc degeneration, osteophyte formation, and hypertrophy of spinal canal ligaments. Diagnosis is primarily made with clinical history and examination in order to assess for classic myelopathic signs (motor weakness, hyperreflexia, and other specific tests). Radiologic imaging is used to validation the diagnosis and to determine the extent of stenosis. Magnetic resonance imaging is the most useful and noninvasive modality. Cervical spinal stenosis without myelopathy can be managed nonsurgically with strengthening, physical therapy, traction, orthosis, and pain management (cervical epidural steroid injections and selective nerve root blocks). Cervical spondylolisthesis has received insufficient attention in comparison to spondylolisthesis of the lumbar spine. It is primarily considered a surgical condition, yet few publications have been dedicated to the topic.

This chapter focuses on conditions that may impact on the formation of a contract. The typical ‘conditional contract’ is the agreement that is expressed to be ‘subject to’ the performance or occurrence of some event that is not certain to occur. The event itself is termed a ‘contingency’ and it is the contract or its performance that is termed ‘conditional’. The contingency may be one requiring some conduct or decision to be made by one of the parties, or a third party, or it may refer to some other event that is out of the control of anyone such as an act of nature. The chapter discusses the ‘subject to contract’ provisions; ‘subject to finance’ clauses; other ‘subject to’ clauses; time for the occurrence of contingency; waiver; and the consequences of the failure of a condition.

This chapter provides an exposition of critical international theory as currently expressed and practised. It situates the discussion in perception of disciplinary and global crisis, arguing that crisis is a condition of theoretical critique and critical international theory itself. The chapter discusses the link between knowledge and interests, in which critical international theory’s engagement with the philosophical exercise of self-reflection is a fundamental process of Kantian Enlightenment. The chapter then elaborates the various ways critical international theorists have conceived emancipation and political transformation. The normative, sociological, and praxeological dimensions of critical international theory are considered in relation to the emancipatory rethinking and restructuring of international relations. As a form of reflexive social philosophy in which meta-theoretical imperatives to problematize the self are privileged, mastering dialectical philosophy was and remains essential to the formation of the critical persona in whom critique is both a theoretical attitude and a lived experience.

Music as a non-verbal form of communication and play addresses the core features of autism, such as social impairments, limited speech, stereotyped behaviors, sensory-perceptual impairments, and emotional dysregulation; thus music-based interventions are well established in therapy and education. Music therapy approaches are underpinned by behavioral, creative, sensory-perceptional, developmental, and educational theory and research. The effectiveness of music therapy in the treatment of children with autism spectrum disorder (ASD) is reflected by a huge number of studies and case reports; current empirical studies aim to support evidence-based practice. A treatment guide for improvisational music therapy provides unique interventions to foster social skills, emotionality, and flexibility; in developmental approaches, the formation of interpersonal relationships is key. Since ASD is a lifelong neurodevelopmental condition, music therapy is also appropriate in the treatment of adults with intellectual disability. Diagnostic approaches using musical-interactional settings to assess ASD symptomatology are promising, especially in non-speakers.

Perioperative cardiovascular complications (including myocardial ischaemia and myocardial infarction) are the predominant cause of morbidity and mortality in patients undergoing non-cardiac surgery. The pathophysiology of perioperative myocardial infarction is complex. Prolonged myocardial ischaemia due to the stress of surgery in the presence of a haemodynamically significant coronary lesion, leading to subendocardial ischaemia, and acute coronary artery occlusion after plaque rupture and thrombus formation contribute equally to these devastating events. Perioperative management aims at optimizing the patient’s condition by identification and modification of underlying cardiac risk factors and diseases. The first part of this chapter covers current knowledge on preoperative risk assessment. Current risk indices, the value of additional testing, and new preoperative cardiac risk makers are investigated. During recent decades there has been a shift from the assessment and treatment of the underlying culprit coronary lesion towards a systemic medical therapy aiming at prevention of myocardial oxygen supply–demand mismatch and coronary plaque stabilization. In the second part of this chapter, risk-reduction strategies are discussed, including β‎-blocker therapy, statins, and aspirins. A central theme in this chapter will focus on long-term cardiovascular risk reduction. Patients who undergo non-cardiac (vascular) surgery are particularly prone to long-term adverse cardiac outcomes. The goal of perioperative cardiovascular risk identification and modification should not be limited to the perioperative period, but should extend well into the postoperative period.

Mystagogical education of the teaching staff in the contemporary civilizatory metamorphose deals with the deep transformations which the civilization passes through, considering the sociological, environmental, political, economic and technological aspects. It deals with human being in this complex relationship analyzing the possible consequences of this process and, in the same way, it points alternative to a right assimilation and the convenience in this new world that rises up result of the metamorphosical process. The main indication remains in comprehending the adoption of mystagogical attitude by the teaching staff and in the formation of the educators. When the subject is the education task intending to overcome its utilitaristic function and preparation for the transactional environment, it suggests that the education points supportive and mystical alternatives in the teaching / learning. It proposes the cultivation and the preparation of the integrator people which teaching condition gets over the technical and the professional perspective, being firstly mystagogos (mystic educators) i.e, people teaching more with their lives and examples than words and contents. The text suggests that the educator’s task is to value the relationship between ourselves, others, the world and the supernatural. The searching points that more than technically prepared teachers, the mystic takes in account the human dimension considering all the potentiallities of the human being to develop himself under professional, intellectual, emotional, spiritual and social point of view.

Debates about the value of the ‘literary’ rarely register the expressive acts of state subsidy, sponsorship, and cultural policy that have shaped post-war Britain. In State Sponsored Literature, Asha Rogers argues that the modern state was a major material condition of literature, even as its efforts were relative, partial, and prone to disruption. Drawing from neglected and occasionally unexpected archives, she shows how the state became an integral and conflicted custodian of literary freedom in the postcolonial world as beliefs about literature’s ‘public’ were radically challenged by the unrivalled migration to Britain at the end of Empire. State Sponsored Literature retells the story of literature’s place in modern Britain through original analysis of the institutional forces behind canon-formation and contestation, from the literature programmes of the British Council and Arts Council to the UK’s fraught relations with UNESCO, from GCSE literature anthologies to the origins of The Satanic Verses in migrant Camden. The state did not shape literary production in a vacuum, Rogers argues, rather its policies, practices, and priorities were inexorably shaped in turn. Demonstrating how archival work can potentially transform our understanding of literature and its reading publics, this book challenges how we think about literature’s value by asking what state involvement has meant for writers, readers, institutions, and the ideal of autonomy itself.

It has been clear for several decades from comparison with the rodent model disease Heymann nephritis that membranous glomerulonephritis (MGN) is an immune condition in which antibodies, usually autoantibodies, bind to targets on the surface of podocytes. However, the antigen in Heymann nephritis, megalin, is not present on human podocytes. The first potential antigen was identified by studying rare examples of maternal alloimmunization, leading to congenital membranous nephropathy in the infant caused by antibodies to neutral endopeptidase. More recently, the target of autoantibody formation in most patients with primary MGN has been identified to be the phospholipase A2 receptor, PLA2R. Genome-wide association studies identify predisposing genetic loci at HLADQ and at the locus encoding the autoantigen itself. So antibodies to at least two different molecular targets can cause MGN, and it seems likely that there may be other targets in secondary types of MGN, and possibly haptenized or otherwise modified molecules are implicated in drug- and toxin-induced MGN. Once antibodies are fixed, animal models and human observations suggest that complement is involved in mediating tissue damage. However, immunoglobulin G4, not thought to fix complement, is the predominant isotype in human MGN, and the mechanisms are not fully unravelled. Podocyte injury is known to cause proteinuria. In MGN, antibody fixation or cell damage may stimulate production of extracellular matrix to account for the increased GBM thickness with ‘podocyte type’ basement membrane collagen isoforms, and ultimately cell death and glomerulosclerosis.

Alegal reveals modern Okinawa to be suspended in a perpetual state of exception: it is neither an official colony of Japan or the U.S., nor an equal part of the Japanese state. Today it is the site of one of the densest concentrations of U.S. military bases globally—a truly exceptional condition stemming from Japan’s abhorrence toward sexual contact around bases in its mainland that factored into securing Okinawa as a U.S. military fortress. This book merges Foucauldian biopolitics with Japanese Marxist theorizations of capitalism to trace the formation of a Japanese middle class that disciplined and secured the population from perceived threats, including the threat of miscegenation. Through close readings of poetry, reportage, film, and autobiography, it reveals how this threat came to symbolize the infringement of Japanese sovereignty figured in terms of a patriarchal monoethnic state. This symbolism, however, was met with great ambivalence in Okinawa. As a borderland of the Pacific, racial politics internal to the U.S. collided with colonial politics internal to the Asia Pacific in base towns centered on facilitating encounters between G.I.s and Okinawan women. By examining the history, debates, and cultural representations of these actors from 1945 to 2015, this book shows how they continually failed to “become Japanese.” Instead, they epitomized Okinawa’s volatility that danced on the razor’s edge between anarchistic insurgency and fascistic collaboration. What was at stake in their securitization was the attempt to contain Okinawa’s alegality itself—that is, a life force irreducible to the law.

This book analyzes the relationship between liberalism and empire from the perspective of political economy. It investigates the formative impact of “colonial capitalism” on the historical development of British liberal thought between the late seventeenth and early nineteenth centuries. It argues that liberalism as a political language developed through early modern debates over the contested meanings of property, exchange, and labor, which it examines respectively in the context of colonial land appropriations in the Americas, militarized trading in South Asia, and state-led proletarianization in Australasia. The book contends that the British Empire could be extolled as the “empire of liberty”—that is, the avatar of private property, free trade, and free labor—only on the condition that its colonial expropriation, extraction, and exploitation were “disavowed” and dissociated from the increasingly liberal conception of its capitalist economy. It identifies exemplary strategies of disavowal in the works of John Locke, Edmund Burke, and Edward G. Wakefield, who, as three liberal intellectuals of empire, attempted to navigate the ideological tensions between the liberal self-image of Britain and the violence that shaped its imperial economy. Challenging the prevalent tendency to study liberalism and empire around an abstract politics of universalism and colonial difference, the book discloses the ideological contradictions internal to Britain’s imperial economy and their critical influence on the formation of liberalism. It concludes that the disavowal of the violence constitutive of capitalist relations in the colonies has been crucial for crafting a liberal image for Anglophone imperialism and more generally for global capitalism.