Journal articles on the topic 'Conditional inducible rat knockdown'
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Sidorova, Maria, Golo Kronenberg, Susann Matthes, et al. "Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior." Cells 10, no. 11 (2021): 3240. http://dx.doi.org/10.3390/cells10113240.
Full textBerger, Stefan M., Iván Fernández-Lamo, Kai Schönig, et al. "Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats." Genome Biology 18, no. 1 (2017): 222. https://doi.org/10.1186/s13059-017-1350-8.
Full textZhang, Hui, Neil B. Sweezey, and Feige Kaplan. "LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 4 (2015): L391—L402. http://dx.doi.org/10.1152/ajplung.00119.2014.
Full textFlemming, Sven, Anny-Claude Luissint, Dennis H. M. Kusters, et al. "Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration." Molecular Biology of the Cell 31, no. 6 (2020): 407–18. http://dx.doi.org/10.1091/mbc.e19-12-0692.
Full textOgawa, Yoshitaka, Kohei Nishimura, Keisuke Obara, and Takumi Kamura. "Development of AlissAID system targeting GFP or mCherry fusion protein." PLOS Genetics 19, no. 6 (2023): e1010731. http://dx.doi.org/10.1371/journal.pgen.1010731.
Full textkun, Zhang, Yang yuling, Wang dongchun, Xie bingbing, Li xiaoli та Xu bin. "HIF-1α Inhibition Sensitized Pituitary Adenoma Cells to Temozolomide by Regulating Presenilin 1 Expression and Autophagy". Technology in Cancer Research & Treatment 15, № 6 (2016): NP95—NP104. http://dx.doi.org/10.1177/1533034615618834.
Full textMakino‐Itou, Hatsune, Noriko Yamatani, Akemi Okubo, et al. "Establishment and characterization of mouse lines useful for endogenous protein degradation via an improved auxin‐inducible degron system (AID2)." Development, Growth & Differentiation 66, no. 7 (2024): 384–93. http://dx.doi.org/10.1111/dgd.12942.
Full textWiznerowicz, Maciej, and Didier Trono. "Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference." Journal of Virology 77, no. 16 (2003): 8957–51. http://dx.doi.org/10.1128/jvi.77.16.8957-8951.2003.
Full textTsai, Steven C., David F. Chang, Chang-Mu Hong, et al. "Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency." American Journal of Physiology-Cell Physiology 306, no. 12 (2014): C1108—C1118. http://dx.doi.org/10.1152/ajpcell.00205.2013.
Full textWeis, Sara M., Ssang-Taek Lim, Kimberly M. Lutu-Fuga, et al. "Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK." Journal of Cell Biology 181, no. 1 (2008): 43–50. http://dx.doi.org/10.1083/jcb.200710038.
Full textWey, Shiuan, Biquan Luo, Chun-Chih Tseng, et al. "Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling." Blood 119, no. 3 (2012): 817–25. http://dx.doi.org/10.1182/blood-2011-06-357384.
Full textKotnik, Katarina, Elena Popova, Mihail Todiras, et al. "Inducible Transgenic Rat Model for Diabetes Mellitus Based on shRNA-Mediated Gene Knockdown." PLoS ONE 4, no. 4 (2009): e5124. http://dx.doi.org/10.1371/journal.pone.0005124.
Full textAzarnia, R., and W. R. Loewenstein. "Polyomavirus middle T antigen downregulates junctional cell-to-cell communication." Molecular and Cellular Biology 7, no. 2 (1987): 946–50. http://dx.doi.org/10.1128/mcb.7.2.946-950.1987.
Full textAzarnia, R., and W. R. Loewenstein. "Polyomavirus middle T antigen downregulates junctional cell-to-cell communication." Molecular and Cellular Biology 7, no. 2 (1987): 946–50. http://dx.doi.org/10.1128/mcb.7.2.946.
Full textOuvrard-Pascaud, Antoine, Stefania Puttini, Yannis Sainte-Marie, et al. "Conditional gene expression in renal collecting duct epithelial cells: use of the inducible Cre-lox system." American Journal of Physiology-Renal Physiology 286, no. 1 (2004): F180—F187. http://dx.doi.org/10.1152/ajprenal.00301.2002.
Full textAlonso, Lucille, Polina Peeva, Tania Fernández-del Valle Alquicira, et al. "Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats." International Journal of Molecular Sciences 25, no. 9 (2024): 5003. http://dx.doi.org/10.3390/ijms25095003.
Full textLee, Sun Young, Ka Hyon Park, Gyuseok Lee та ін. "Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss". Experimental & Molecular Medicine 53, № 4 (2021): 591–604. http://dx.doi.org/10.1038/s12276-021-00594-y.
Full textZhang, Huimin, Qi Zheng, and Ruby Yanru Chen-Tsai. "Establishment of a Cre-rat resource for creating conditional and physiological relevant models of human diseases." Transgenic Research 30, no. 1 (2021): 91–104. http://dx.doi.org/10.1007/s11248-020-00226-7.
Full textHemmrich, Karsten, Christoph V. Suschek, Guido Lerzynski, Oliver Schnorr, and Victoria Kolb-Bachofen. "Specific iNOS-targeted antisense knockdown in endothelial cells." American Journal of Physiology-Cell Physiology 285, no. 2 (2003): C489—C498. http://dx.doi.org/10.1152/ajpcell.00045.2003.
Full textStahl, Andreas, Jean-Sebastian Joyal, Jing Chen, et al. "SOCS3 is an endogenous inhibitor of pathologic angiogenesis." Blood 120, no. 14 (2012): 2925–29. http://dx.doi.org/10.1182/blood-2012-04-422527.
Full textDe Conti, Giulia, Alicja M. Gruszka, Debora Valli, et al. "A Novel Platform to Test In Vivo Single Gene Dependencies in t(8,21) and t(15,17) AML Confirms Zeb2 as Leukemia Target." Cancers 12, no. 12 (2020): 3768. http://dx.doi.org/10.3390/cancers12123768.
Full textZhao, Meng, Xu-Yun Zhao, Shi-Hua Liao, Ke-Wen Zhao, Li-Shun Wang та Guo-Qiang Chen. "The Potential Role of Galectin-1 in Hypoxia Induced AML Cell Differentiation through C/EBPαa Transcription Regulation." Blood 114, № 22 (2009): 3120. http://dx.doi.org/10.1182/blood.v114.22.3120.3120.
Full textReichhart, Nadine, Sergio Crespo-Garcia, Nadine Haase, et al. "The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown." Diabetologia 60, no. 1 (2016): 202–11. http://dx.doi.org/10.1007/s00125-016-4115-0.
Full textKanyo, R., D. M. Price, C. L. Chik, and A. K. Ho. "Salt-Inducible Kinase 1 in the Rat Pinealocyte: Adrenergic Regulation and Role in Arylalkylamine N-Acetyltransferase Gene Transcription." Endocrinology 150, no. 9 (2009): 4221–30. http://dx.doi.org/10.1210/en.2009-0275.
Full textAmeis, Dustin, Franklin Liu, Eimear Kirby, Daywin Patel, and Richard Keijzer. "The RNA-binding protein Quaking regulates multiciliated and basal cell abundance in the developing lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 4 (2021): L557—L567. http://dx.doi.org/10.1152/ajplung.00481.2019.
Full textZhan, Wenxing, Liping Chen, Hongfei Liu, et al. "Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress." Genes 13, no. 4 (2022): 711. http://dx.doi.org/10.3390/genes13040711.
Full textFang, Yi, Xiaofang Yu, Yong Liu та ін. "miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation". American Journal of Physiology-Renal Physiology 304, № 10 (2013): F1274—F1282. http://dx.doi.org/10.1152/ajprenal.00287.2012.
Full textGiles, Jasmine, Jitandrakumar R. Patel, Adam Miller, Elizabeth Iverson, Daniel Fitzsimons, and Richard L. Moss. "Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C." Journal of General Physiology 151, no. 1 (2018): 77–89. http://dx.doi.org/10.1085/jgp.201812238.
Full textChu, Miensheng, Yevgeniya Koshman, Rekha Iyengar, Taehoon Kim, Brenda Russell, and Allen M. Samarel. "Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NOi Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway." Journal of Signal Transduction 2012 (July 26, 2012): 1–11. http://dx.doi.org/10.1155/2012/473410.
Full textAzevedo, Mauro F., Paul R. Sanders, Efrosinia Krejany, et al. "Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development." Biochemical Journal 452, no. 3 (2013): 433–41. http://dx.doi.org/10.1042/bj20130124.
Full textLin, En-Shyh, Yu-An Hsu, Ching-Yao Chang, Hui-Ju Lin, Chih Sheng Chen, and Lei Wan. "Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization." International Journal of Molecular Sciences 21, no. 15 (2020): 5511. http://dx.doi.org/10.3390/ijms21155511.
Full textHerr, Barbara, Jie Zhou, Christian Werno та ін. "The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor–1α in macrophages via sphingosine-1-phosphate and transforming growth factor-β". Blood 114, № 10 (2009): 2140–48. http://dx.doi.org/10.1182/blood-2009-01-201889.
Full textYan, Xiaoying, Ran Zhao, Xiaorong Feng та ін. "Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1α-TAK1 signalling pathway". Cardiovascular Research 116, № 1 (2019): 114–26. http://dx.doi.org/10.1093/cvr/cvz064.
Full textShibahara, Daisuke Jefferson, Naoki Akanuma, Eunyoung Heo, et al. "Abstract 3723: Role of KAT5 in non-small cell lung cancer." Cancer Research 82, no. 12_Supplement (2022): 3723. http://dx.doi.org/10.1158/1538-7445.am2022-3723.
Full textFigueiredo, Marta, Arezoo Daryadel, Gabin Sihn, et al. "The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule." Pflügers Archiv - European Journal of Physiology 473, no. 8 (2021): 1229–46. http://dx.doi.org/10.1007/s00424-021-02598-z.
Full textCsiszar, Anna, Nazar Labinskyy, Andrej Podlutsky, et al. "Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 6 (2008): H2721—H2735. http://dx.doi.org/10.1152/ajpheart.00235.2008.
Full textAbraham, Ajay, Puneet Agarwal, Hui Li, Andrew Paterson, Jianbo He, and Ravi Bhatia. "Inhibition of CML Development Following Conditional SIRT1 Deletion in Transgenic BCR-ABL Mice." Blood 128, no. 22 (2016): 931. http://dx.doi.org/10.1182/blood.v128.22.931.931.
Full textVukovic, Milica, Amelie V. Guitart, Catarina Sepulveda та ін. "Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance". Journal of Experimental Medicine 212, № 13 (2015): 2223–34. http://dx.doi.org/10.1084/jem.20150452.
Full textDuque, Cristiane, Rafael N. Stipp, Bing Wang, et al. "Downregulation of GbpB, a Component of the VicRK Regulon, Affects Biofilm Formation and Cell Surface Characteristics ofStreptococcus mutans." Infection and Immunity 79, no. 2 (2010): 786–96. http://dx.doi.org/10.1128/iai.00725-10.
Full textBrown, Stephen T., та Colin A. Nurse. "Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line". American Journal of Physiology-Cell Physiology 294, № 6 (2008): C1305—C1312. http://dx.doi.org/10.1152/ajpcell.00007.2008.
Full textWeaver, Ian C. G., Ian C. Hellstrom, Shelley E. Brown, et al. "The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1652 (2014): 20130513. http://dx.doi.org/10.1098/rstb.2013.0513.
Full textChakraborty, Damayanti, Wei Cui, Gracy X. Rosario, et al. "HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia." Proceedings of the National Academy of Sciences 113, no. 46 (2016): E7212—E7221. http://dx.doi.org/10.1073/pnas.1612626113.
Full textKobayashi, Eri, Ritsuko Shimizu, Yuko Kikuchi, Satoru Takahashi, and Masayuki Yamamoto. "Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of GATA1 Protein Lacking the N-Terminal Domain." Blood 114, no. 22 (2009): 3648. http://dx.doi.org/10.1182/blood.v114.22.3648.3648.
Full textMcTague, J., M. Ferguson, C. L. Chik, and A. K. Ho. "Sustained Adrenergic Stimulation Is Required for the Nuclear Retention of TORC1 in Male Rat Pinealocytes." Endocrinology 154, no. 9 (2013): 3240–50. http://dx.doi.org/10.1210/en.2013-1293.
Full textZhang, Wei, Xiangjun Zhou, Qisheng Yao, Yutao Liu, Hao Zhang, and Zheng Dong. "HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells." American Journal of Physiology-Renal Physiology 313, no. 4 (2017): F906—F913. http://dx.doi.org/10.1152/ajprenal.00178.2017.
Full textWang, Wei, Andrew P. Landstrom, Qiongling Wang, et al. "Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 9 (2014): H1317—H1326. http://dx.doi.org/10.1152/ajpheart.00413.2014.
Full textResnitzky, D., M. Gossen, H. Bujard, and S. I. Reed. "Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system." Molecular and Cellular Biology 14, no. 3 (1994): 1669–79. http://dx.doi.org/10.1128/mcb.14.3.1669-1679.1994.
Full textResnitzky, D., M. Gossen, H. Bujard, and S. I. Reed. "Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system." Molecular and Cellular Biology 14, no. 3 (1994): 1669–79. http://dx.doi.org/10.1128/mcb.14.3.1669.
Full textRen, Kehan, Zongjun Xia, Ermin Li, Xu Han, and Peng Ji. "Rapid Degradation of mDia2 Protein during Terminal Erythropoiesis Via an In Vivo Aid System: An Alternative Approach for Loss-of-Function Studies." Blood 142, Supplement 1 (2023): 2443. http://dx.doi.org/10.1182/blood-2023-178268.
Full textQuerbes, William, Roman Bogorad, Javid Moslehi, et al. "Liver Specific Delivery of siRNA Targeting EGLN Prolyl Hydroxylases Activates Hepatic Erythropoietin Production and Stimulates Erythropoiesis,." Blood 118, no. 21 (2011): 3161. http://dx.doi.org/10.1182/blood.v118.21.3161.3161.
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