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Dissertations / Theses on the topic 'Conformational characterization'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Ambrogi, Martina. "Synthesis, characterization and conformational studies of arylbenzylmaleimides." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/4251/.

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From the discoveries of Pasteur, stereochemistry has played an increasingly important role in the chemical sciences. In particular conformational study of molecules with axial chirality is object of intense research. Through Dynamic-NMR analysis and simulation of the spectra, the energy rotational barriers value of conformers are obtained. When this barrier is high sufficiently, atropisomeric stable compounds can be reached. They can be separated and used in stereo-synthesis and in packing processes. 3,4-bis-aryl maleimides, in which the aromatic groups are sufficiently bulky, generate atropi

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2

Silenzi, Ilaria. "Synthesis, characterization and conformational studies of bis-phenothiazine-aryl-boranes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19201/.

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This thesis project presents a work based on the study of a particular class of amino-boranes, called bis-phenothiazine-aryl-boranes. The peculiarity of these compounds is the N-B-N chemical moiety and their complex conformational behaviour, due to the combination of steric hindrance and conjugation of the B-N bond. Our work is focused on two main products with different symmetry: bis-phenothiazine-2-methylnaphthyl-borane (2b) and bis-phenothiazine-anthracenyl-borane (2c). We firstly focused our attention on an effective way of synthesis, by optimizing both reaction conditions and purification

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3

Zych, Andrew John. "Conformational characterization of abiotic secondary structure based on aromatic stacking /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008484.

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4

Foschi, Simone. "Synthesis, Characterization and Conformational Studies of Modified Carbazole-bis-aryl-boranes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20686/.

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During this project we have synthetized different compounds belonging to the class of amino-boranes for the study of bis-aryl-B=N system. We have decided to keep unchanged the aryl components and change only the amine to observe the effect of that on the B=N bond. The used amines are modified carbazoles with functional groups chosen to amplify or disempower the steric and the conjugation effect. We have found that the evaluation of steric barrier was possible studying the gearing aryls rotation around the C-B bonds, while the conjugation barrier is instead given by the energy needed to break t

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5

Croasdale, Rebecca Alice. "Characterization of the conformational dynamics of the Nek2 leucine zipper domain." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/27799.

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Nek2 is a cell cycle regulated protein kinase. Its expression and activity peak in S and G2 phase before the protein is targeted for degradation in mitosis. Nek2 activity promotes centrosome separation and bipolar spindle formation, processes that are essential for maintaining the fidelity of chromosome segregation and cell division. Importantly, Nek2 inhibition results in increased apoptosis and senescence in cancer cell lines and tumour xenografts making Nek2 an attractive target for chemotherapeutic intervention. The α-helix is the most common secondary structure in proteins, with 2-3% of a

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6

Ieronymaki, Matthaia. "Immunological and Conformational characterization of synthetic peptide probes for autoimmune diseases." Thesis, Cergy-Pontoise, 2016. http://www.theses.fr/2016CERG0831/document.

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Les maladies auto-immunes sont des maladies chroniques et hétérogènes caractérisées par des réactions du système immunitaire acquis contre les propres tissus sains de l'organisme. Ces maladies affectent presque 5% de la population mondiale et en particulier les jeunes adultes. La complexité de leur spectre est énorme et même si leur étiologie est encore incertaine, il a été démontré que des facteurs génétiques et environnementaux sont impliqués dans le déclenchement du mécanisme pathologique. Cependant, il est nécessaire d'utiliser des outils diagnostiques et / ou pronostiques fiables pour le

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7

Fisher, Charles. "Statistical Characterization of Protein Ensembles." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10223.

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Conformational ensembles are models of proteins that capture variations in conformation that result from thermal fluctuations. Ensemble based models are important tools for studying Intrinsically Disordered Proteins (IDPs), which adopt a heterogeneous set of conformations in solution. In order to construct an ensemble that provides an accurate model for a protein, one must identify a set of conformations, and their relative stabilities, that agree with experimental data. Inferring the characteristics of an ensemble for an IDP is a problem plagued by degeneracy; that is, one can typically const

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8

Niyogi, Sandip. "Synthesis and characterization of molecules to study the conformational barriers of fluorocarbon chains." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2511/.

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Fluorocarbons are known to be stiffer than their hydrocarbon analogues, a property that underlines the extensive industrial application of fluorocarbon materials. Although there has been previous studies on the rotational barrier of molecules having fluorocarbon centers, a detailed systematic study is necessary to quantify flurocarbon stiffness. The molecules, Pyrene-(CF2)n-Pyrene, Pyrene-(CF2)n-F, Pyrene-(CH2)n-Pyrene and Pyrene-(CH2)n-H were therefore synthesized to enable the determination of the barrier to rotation of the carbon backbone in fluorocarbons. Conformational studies will be com

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9

Cherwa, Jr James Edward. "Characterization of Scaffolding Proteins Altered in the Ability to Perform a Critical Conformational Switch." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195476.

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Throughout recent history scientists have struggled to elucidate the biochemical and biophysical mechanisms that guide the assembly of macromolecular structures. The early models of "sub-assembly" or "self assembly" attempted to explain how individual components could interact in a precisely regulated manner to form higher-ordered complex biological structures. Subsequent studies, using viral systems as assembly models, demonstrated how protein-protein and protein-nucleic acid interactions assist in lowering the thermodynamic barriers that typically disfavor assembly.Due to their simplicity, v

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10

Braggin, Greg A. "Effect of Surfactant Architecture on Conformational Transitions of Conjugated Polyelectrolytes." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1411.

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Water soluble conjugated polyelectrolytes (CPEs), which fall under the category of conductive polymers, possess numerous advantages over other conductive materials for the fabrication of electronic devices. Namely, the processing of water soluble conjugated polyelectrolytes into thin film electronic devices is much less costly as compared to the processing of inorganic materials. Moreover, the handling of conjugated polyelectrolytes can be performed in a much more environmentally friendly manner than in the processing of other conjugated polymers because conjugated polyelectrolytes are water s

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11

ZUCCHIATTI, PAOLO. "Conformational characterization of functional proteins in physiological environment by Collective Enhancement IR Absorption (CEIRA) microscopy." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2991049.

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The functionality of a protein is interwoven with its structure, small variations in the latter may result in the arise of resistances to drugs or severe pathologies. This is one of the main reasons why the study of protein structure, field of science called structural biology, is of paramount importance and requires a multidisciplinary/multi-technique approach to understand protein structure, function and dynamics. All these analytical tools have their pros and cons, and notably no one technique alone can provide all the answers to the question of structural biology. In this field, a pivotal

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12

Zhang, Xiaofan. "Synthesis, Characterization and Catalytic Studies of Chiral Gold Acyclic Diaminocarbene Complexes." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862827/.

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Chiral gold complexes have been applied in homogeneous catalytic reactions since 1986, in some cases with high enantioselectivity. Acyclic diaminocarbene (ADC) ligands are acyclic analogues of N-heterocyclic carbenes (NHCs) that have larger N-CCarbene-N angles and stronger donating ability. ADCs have been developed as alternatives to phosphine and NHC ligands in homogeneous gold catalysis. In 2012, a new series of chiral gold(I) ADCs were first developed by Slaughter's group and were shown to give remarkable enantioselectivities in some reactions. Because of the hindered rotation of the N-CCar

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13

Lee, Alexis J. "Theoretical Approaches to the Characterization of Water, Aqueous Interfaces, and Improved Sampling of Protein Conformational Changes." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1511.

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Methods to advance the understanding of water and other aqueous systems are devel- oped. This work falls into three areas: The creation of better interaction potentials for water, improved methods for sampling configurational space, and the applications of these methods to understand systems of interest. Charge transfer has been shown by ab initio methods to be important in the water–water and water–ion interactions. A model for treating charge transfer in liquid water and aqueous systems is presented in this manuscript. The model is called Discrete Charge Transfer (DCT) and is based on the co

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14

Pondaven, Simon Pierre. "Conformational Flexibility and Amyloid Core Characterization of Human Immunoglobulin Light Chain Domains by Multidimensional NMR Spectroscopy." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354113457.

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15

Dollery, Stephen. "Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/176.

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Herpesviruses can enter host cells by pH-dependent endocytic pathways in a cell-specific manner. The role of pH in herpesvirus endocytosis is unclear. Herpes simplex virus (HSV) is a paradigm for virus membrane fusion via a complex of glycoproteins. HSV glycoproteins B, D and the heterodimer H-L are necessary and sufficient for membrane fusion. This work analyzes the structure and function of HSV glycoproteins B, D, and H-L at neutral pH, and at the physiological low-pH encountered during endocytic entry. It is demonstrated that mildly acidic low pH triggers specific conformational changes in

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16

Raspadori, Andrea. "Characterization of the conformational space of the murine prion protein using single-molecule force spectroscopy techniques." Doctoral thesis, SISSA, 2014. http://hdl.handle.net/20.500.11767/4124.

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The conversion of the cellular prion protein (PrPC) to its infectious counterpart (PrPSc) is the initial step of prion diseases. These neurodegenerative disorders are characterized by different incubation times, sympthoms and disease phenotypes. Structural heterogenity of PrP aggregates is responsible for this biological diversity. Understanding the structural rearrangements of PrP at the monomeric and oligomeric level is essential to gain insights into its aggregation processes. However traditional “in-bulk” techniques can only provide ensemble-averaged information for monomer and oligomer st

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17

Symeonidou, Evgenia. "Synthesis, characterization and DFT study of new azaborinine compounds." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21700/.

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In the framework of this thesis, a wide-ranging study of azaborinine derivatives was conducted, with a particular interest towards 9,10-B,N-phenanthrenes, holding an isosteric B-N unit in the place of a C=C bond and incorporating a B-C chiral axis. For this purpose, a preliminary theoretical study for four compounds of this class was carried out: conformational analysis and rotational energy barriers, UV-Vis absorption and fluorescence emission as well as theoretical ECD spectra of the atropisomeric structures were calculated by means of DFT and TD-DFT. An experimental attempt to synthesize an

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18

Posgai, Monica Therese. "Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding". University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1354043317.

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19

Zhao, Shen. "Design and in vitro characterization of lipids with a pH-sensitive conformational switch and their liposomes for anticancer drug delivery." Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3574.

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The traditional anticancer drugs are distributed in vivo through systemic blood circulation with a very small portion reaching the tumor site. Targeted drug delivery systems are developed in efforts to concentrate the drug molecules in the tissue of interest while reducing the drug distribution to healthy tissues to reduce the side effects. Liposomes are colloidal systems composed of amphiphilic molecules that assemble into vesicle structures in aqueous media. They are common carriers for targeted drug delivery with the advantages of low toxicity, low immunogenicity and the ability of encap

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20

TESTA, LORENZO. "Conformational transitions of the intrinsically disordered protein sic1 from the yeast saccharomyces cerevisiae. Towards structural and functional characterization of the whibitory complex with CDK1-CLB5." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43673.

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Many naturally occurring proteins have been shown to lack rigid three-dimensional structure, existing instead as dynamic ensembles of inter-converting conformations. Many of these proteins acquire an ordered structure only upon binding to specific intracellular partners. In isolation, these proteins exhibit a highly dynamic structure that is resembling more the denatured rather than native state of “normal” globular proteins. Intrinsically disordered proteins (IDPs) have attracted a great deal of interest since it became clear that their lack of structural specificity is of physiological impor

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21

Malloni, Wilhelm Massimiliano [Verfasser], and Hans Robert [Akademischer Betreuer] Kalbitzer. "AUREMOL-QTA, a program package for NMR based automated recognition and characterization of local and global conformational changes in proteins induced by ligand binding as external perturbation / Wilhelm Massimiliano Malloni. Betreuer: Hans Robert Kalbitzer." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1030178836/34.

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22

Rauch, Sebastian, Klaus-Jochen Eichhorn, Ulrich Oertel, Manfred Stamm, Dirk Kuckling, and Petra Uhlmann. "Temperature responsive polymer brushes with clicked rhodamine B: synthesis, characterization and swelling dynamics studied by spectroscopic ellipsometry." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-139314.

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Here, we report on a new temperature responsive polymer brush system with a terminal “click” functionality. Bifunctionalized poly(N-isopropylacrylamide) (PNiPAAm) with distinct functional end groups was synthesized by atom transfer radical polymerization (ATRP) and grafted to a modified silicon substrate. The presence of the active terminal alkyne functionality is validated using an azide-modified rhodamine B (N3-RhB) via copper(I) catalyzed alkyne–azide cycloaddition (CuAAC). The optical properties and swelling dynamics of an N3-RhB modified PNiPAAm brush are analyzed in dry state and in situ

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23

Rauch, Sebastian, Klaus-Jochen Eichhorn, Ulrich Oertel, Manfred Stamm, Dirk Kuckling, and Petra Uhlmann. "Temperature responsive polymer brushes with clicked rhodamine B: synthesis, characterization and swelling dynamics studied by spectroscopic ellipsometry." Royal Society of Chemistry, 2012. https://tud.qucosa.de/id/qucosa%3A27823.

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Here, we report on a new temperature responsive polymer brush system with a terminal “click” functionality. Bifunctionalized poly(N-isopropylacrylamide) (PNiPAAm) with distinct functional end groups was synthesized by atom transfer radical polymerization (ATRP) and grafted to a modified silicon substrate. The presence of the active terminal alkyne functionality is validated using an azide-modified rhodamine B (N3-RhB) via copper(I) catalyzed alkyne–azide cycloaddition (CuAAC). The optical properties and swelling dynamics of an N3-RhB modified PNiPAAm brush are analyzed in dry state and in situ

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24

Naidoo, Kevin Jonathan. "Metal ion cages with stabilized conformations : synthesis, characterization and properties." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/18805.

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The stabilized conformers lel₃, lel₂ob, ob₂lel and ob₃ of the [Co(±pn)₃]³⁺ system have previously been synthesized giving relative equilibrium (100 °C) amounts of 35.0 : 41.1 : 18.0 : 4.0. With the recent encapsulation of the resolved lel₃-[Co(pn)₃₋]Cl₃ complexes, and their subsequent interconversion to the ob₃-[Co(NH₃)₂-pnsar]Cl₅ diastereomers, the synthesis of the lel₂ob and ob₂lel cage complexes is a necessity to complete the investigation of the [Co(NH₃)₂-pnsar]⁵⁺ system. Consequently the eight Δ, Λ isomers of the lel₂ob-[Co(NH₃)₂-pnsar]Cl₅ complex were synthesised in a one pot reaction an

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25

Mossuto, Maria Francesca. "Protein amyloidogenesis: characterization of aggregation prone conformations and fibrils structure." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425566.

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Current interest in studying amyloid fibrils arises from their involvement in different fields (Chiti and Dobson, 2006). First, they play a crucial role in disorders such as Alzheimer's and Parkinson's diseases. Second, since it has been demonstrated that all polypeptide chains form fibrils under appropriate conditions, the understanding of why and how this process happens has become central problem in protein knowledge. Last, the ordered ultrastructure characterizing amyloid fibrils may be thought as a basis for nanomaterials with possible technological applications. However, despite the abil

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26

Kallberg, Yvonne. "Bioinformatic methods in protein characterization /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-370-8/.

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27

Banks, Jennifer Dawn. "Characterization of a minimal avian leukosis-sarcoma virus packaging signal /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11528.

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28

Park, Sunho 1976. "Characterization of nanoparticle-DNA conjugate and control of DNA conformation on particle surface." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/49761.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Includes bibliographical references.<br>Nano-science has exploited the hybridization and de-hybridization phenomena of DNA which are one of its fundamental functions. In particular, conjugates of gold nanoparticles and DNA (Au NP-DNA) have been extensively explored for their potential in biological applications such as DNA delivery for gene therapy and disease detection. However, DNA strands are known to adsorb onto the Au NP surface, which can severely limit the hybridization ability of Au NP-DNA

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29

Spuhler, Philipp S. "High-throughput detection of DNA orientation and conformation for characterization of protein-DNA interactions." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31605.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>A deep understanding of disease processes requires understanding of DNA, RNA and protein function on a molecular level. Protein-DNA interactions play a crucial role in many of these processes, including in ge

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30

Tseng, Hui-yuan [Verfasser], and Reinhard [Akademischer Betreuer] Fässler. "Identification and characterization of conformation-specific cytoplasmic integrin interactors / Hui-yuan Tseng ; Betreuer: Reinhard Fässler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1124395806/34.

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31

Farooqi, Mohammed Junaid. "METHODS FOR IN SITU PIEZOPHYSIOLOGICAL STUDIES: OPTICAL SECTIONING VIA STRUCTURED ILLUMINATION AND FLUORESCENCE BASED CHARACTERIZATION OF NADH CONFORMATION." Oxford, Ohio : Miami University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1249225952.

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32

Xia, Nan. "Time-of-flight secondary ion mass spectrometry (ToF-SIMS) characterization of conformation and orientation of adsorbed protein films /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/9869.

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33

Holder, Isabelle T. [Verfasser]. "Non-Canonical Nucleic Acids in Bacteria -Structural Characterization and Functional Properties of Quadruplex and Triplex Conformations- / Isabelle T. Holder." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1110771606/34.

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34

Meyer, Gordon Joel. "Synthesis, Characterization, and Mixed-Valence Studies of Conformationally Constrained Bisferrocenyl Complexes for the Study of Through-Space S***π; Interactions". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337289.

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A series of conformationally constrained 2,6-bisferrocenylphenyl thioethers were synthesized via Suzuki-Miyaura cross coupling reactions. Structural information was obtained using X-ray crystallography and dynamic ¹H NMR spectroscopic studies, showing highly constrained m-terphenyl systems. Interaction of the ferrocene moieties through space mediated by the sulfur were studied by ultra-violet photoelectron spectroscopy (UPS), cyclic voltammetry, differential pulse voltammetry, UV-Vis-NIR spectroscopy and DFT computations. Electrochemical results show two, fully reversible 1e⁻ redox processes f

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35

Agrahari, Aditya. "Synthesis and Characterization of Di- Aryl Pentanes and Mechanistic Study of Aldol Reaction of 9-Acetylanthracene with Paraformaldehyde." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1440082002.

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[Verfasser], Felix Helge Deluweit, and Christiane [Akademischer Betreuer] Ritter. "Conformation based in vitro selection of mammalian prion seeds – Propagation and characterization of prion strains / Felix Helge Deluweit ; Betreuer: Christiane Ritter." Braunschweig : Technische Universität Braunschweig, 2015. http://d-nb.info/1175819646/34.

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Han, Zhong. "Characterization of the mechanisms of transcription termination by the helicase Sen1." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS202/document.

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La transcription cachée est un phénomène répandu aussi bien chez les eucaryotes que chez les procaryotes. Elle se caractérise par une production massive d’ARNs non-codants au niveau de régions non-annotées du génome et est potentiellement dangereuse pour la cellule car elle peut interférer avec l’expression normale des gènes. Chez S. cerevisiae, l’hélicase Sen1 induit la terminaison précoce de la transcription non-codante et joue ainsi un rôle clé dans le contrôle de la transcription cachée. Sen1 est très conservée et des mutations dans son homologue humain, senataxin (SETX), ont été associées

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Francou, Bruno. "Contribution à la caractérisation de nouveaux gènes impliqués dans les hypogonadismes hypogonadotropes : caractérisation des mécanismes moléculaires et cellulaires." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS101/document.

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Les hypogonadismes hypogonadotropes congénitaux (CHH) sont des maladies héréditaires caractérisées par un déficit de sécrétion des gonadotrophines par l’hypophyse, à l’origine d’une infertilité ou d’une absence complète de puberté. On distingue les formes isolées avec olfaction normale (nCHH) et les formes syndromiques associant au déficit gonadotrope d’autres signes, tel qu’un défaut d’olfaction dans le cas du syndrome de Kallmann (SK), la forme plus fréquente de CHH. Les gènes identifiés dans le SK participent au développement embryonnaire et les gènes des nCHH sont impliqués dans la régulat

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Raphela, Mashikoane Pinky Jane. "Molecular characterization of Mycoplasma synoviae in chickens in South Africa using single-stranded conformation polymorphism and high-resolution melting curve analysis of the vlhA gene." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/26196.

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Mycoplasma synoviae (Ms) causes respiratory infection and synovitis in chickens and turkeys and is an economically important pathogen of poultry worldwide. It is critically important to characterize Ms strains, especially in countries in which poultry flocks are vaccinated with the live attenuated Ms strain MS-H. Vaccination with this vaccine may cause sero-conversion and persistence of the vaccine strain in the respiratory tract and will frequently result in positive Ms cultures and PCR results. Vaccination of flocks therefore complicates the diagnosis of Ms by the presence of detectable anti

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Coty, Jean-Baptiste. "Caractérisation des nanomédecines pour la clinique : développement de méthodes évaluant les interactions nanoparticules-protéines plasmatiques pour une application en contrôle qualité." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS432/document.

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Les nanomédecines injectées par voie intraveineuse interagissent avec les éléments biologiques qui les entourent dans le compartiment sanguin. Parmi ces interactions, celles avec les protéines sanguines se révèlent être très importantes dans le devenir de ces nanovecteurs, leur conférant une identité biologique influençant leur chemin jusqu’au tissu et aux cellules cibles. La compréhension et le contrôle de ces phénomènes reste un enjeu crucial dans le développement des nanomédecines. Des méthodes permettant une étude facilitée de ces interactions sont nécessaires à cet égard. Les travaux de c

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41

Fleischmann, Matthias [Verfasser], Ruth M. [Akademischer Betreuer] Gschwind, Kirsten [Akademischer Betreuer] Zeitler, and Manfred [Akademischer Betreuer] Scheer. "NMR investigations on catalysts and conformations in organo- and photocatalytic reactions, and characterization of electrolytes and supramolecular switchable container molecules / Matthias Fleischmann. Betreuer: Ruth M. Gschwind ; Kirsten Zeitler ; Manfred Scheer." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1026165520/34.

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42

Xiao, Jianxi. "NMR conformational and dynamic characterization of triple helical peptides." 2009. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051923.

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43

Weng, Shao-En, and 翁紹恩. "Conformational and dynamic characterization of Na+-dependent bile acid transporter ASBTNm." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/q2dsnz.

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碩士<br>國立中興大學<br>生物化學研究所<br>106<br>Apical Sodium-dependent Bile acid Transporter (ASBT), a Na+-dependent secondary active transporter, is localized at the apical membrane of enterocytes and mediates the reuptake of bile acid from ileum back to liver. The structural information of ASBT is attributed to the crystal structures of bacterial homologs ASBTNm and ASBTYf, revealing the snapshots at inward- and outward-facing states, and the putative mechanism of substrate translocation via an “elevator-like” movement. Nevertheless, the triggers of conformational changes and the dynamics at different su

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Simão, Alcides Pinto. "Gas-Phase Conformational Characterization of Trace Amine Neurotransmitters: a rotational spectroscopy study." Doctoral thesis, 2020. http://hdl.handle.net/10316/91053.

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Tese no âmbito do Doutoramento em Química, ramo de Espectroscopia Molecular apresentada ao Departamento de Química da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>A presente dissertação trata das preferências conformacionais de uma série de aminas residuais (octopamina, sinefrina, fenilglicinol e fenilefrina), bem como de um precursor aminoácido (ácido pipecólico) e de um aminossacarídeo (glucosamina), estudadas em condições de isolamento em fase gasosa recorrendo ao uso de uma combinação de técnicas de espectroscopia rotacional hifenada com ablação laser. Livre de qualq

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Hsiao, Chun-Che, and 蕭均哲. "Characterization of the conformational and functional properties of two in vitro refolded Bacillus subtilis SigB." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/73692598406431862636.

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碩士<br>國立中興大學<br>生物化學研究所<br>104<br>Transcription initiation is the first step of gene expression and a major point for gene regulation.σ factor of RNA polymerase (RNAP；α2ββ''σ) confers the specificity of promoter recognition and initiates transcription. It is also involved in open complex, abortive transcription and regulation of gene expression. Recent works in our lab demonstrated that the N-terminally truncated primary σA factor, SND100-σA, and σB of Bacillus subtilis, both of which lack region 1.1, are able to specifically interact with promoter DNA in the absence of core RNA polymerase in

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Baldwin, Richard Kimo. "Preparation, characterization and conformational variability of [eta]6-Hexaethylbenzene and other arene complexes of ruthenium." Phd thesis, 1998. http://hdl.handle.net/1885/144675.

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Nandini, K. "Isolation,Purification and Conformational Characterization of Peanut( Arachis Hypogea) Lectin in the Presence of Chaotropes." Thesis, 2015. http://ethesis.nitrkl.ac.in/7959/1/2015_Isolation_Nandini.pdf.

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Peanut lectin (PNA) is a plant protein isolated and purified from its natural source Arachis hypogea using biophysical technique called salting out, and analytical technique called size exclusion chromatography, respectively. The isolated lectin was characterised by SDS-PAGE followed by FT-IR study of peanut lectin, which gives the secondary structure of peanut protein. The FTIR data were further strengthened using Circular Dichroism spectropolarimeter. Although peanut lectin comprises majorly of ß-sheet, the protein gave strong negative ellipticity at ~223 nm, a signature of lectin proteins.

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ZHANG, JIANMING. "Conformational and Mechanical Characterization of Organic Thin Films on Surfaces by Neutron Reflection and Atomic Force Microscopy." Diss., 2014. http://hdl.handle.net/10161/9400.

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<p>Engineering thin, organic materials with tailored properties requires both the understanding of the conformation of thin organic films and their conformational response to changes in the environment, and the accurate characterization the mechanical properties of the materials as a thin layer on surfaces. These issues have not yet been sufficiently addressed due to the paucity of appropriate tools and data interpretation approaches to reveal the nanometer scale conformation and mechanics of surface-grafted, thin, organic films. In this dissertation, I report on the characterization of confor

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Hansen, Jeffrey Craig. "Characterization of the conformational transitions of the estrogen receptor monomer by partition in aqueous two-phase systems." 1986. http://catalog.hathitrust.org/api/volumes/oclc/15244978.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1986.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 153-162).

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Ujvari, Andrea. "Characterization of DNA structural elements and conformational changes accompanying the binding of T7 RNA polymerase to its promoter." 1999. https://scholarworks.umass.edu/dissertations/AAI9920662.

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The first step of transcription initiation, promoter binding, is characterized in the T7 RNA polymerase model system. A previous two-domain model for the T7 RNA polymerase promoter is tested by the use of different fluorescence methods. The increase in the fluorescence anisotropy of a rhodamine dye linked to the upstream end of the promoter provides a very sensitive measure of enzyme binding in simple thermodynamic titrations (best fit value of Kd is calculated to be 4.0 nM), and is the first quantitative assay to reliably measure both increases and decreases in the dissociation constant. The

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