Relevant bibliographies by topics / Conjugated dendrimer

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Academic literature on the topic 'Conjugated dendrimer'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Conjugated dendrimer"

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Liu, Jie, Warren D. Gray, Michael E. Davis, and Ying Luo. "Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review." Interface Focus 2, no. 3 (March 21, 2012): 307–24. http://dx.doi.org/10.1098/rsfs.2012.0009.

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Dendrimers comprise a category of branched materials with diverse functions that can be constructed with defined architectural and chemical structures. When decorated with bioactive ligands made of peptides and saccharides through peripheral chemical groups, dendrimer conjugates are turned into nanomaterials possessing attractive binding properties with the cognate receptors. At the cellular level, bioactive dendrimer conjugates can interact with cells with avidity and selectivity, and this function has particularly stimulated interests in investigating the targeting potential of dendrimer materials for the design of drug delivery systems. In addition, bioactive dendrimer conjugates have so far been studied for their versatile capabilities to enhance stability, solubility and absorption of various types of therapeutics. This review presents a brief discussion on three aspects of the recent studies to use peptide- and saccharide-conjugated dendrimers for drug delivery: (i) synthesis methods, (ii) cell- and tissue-targeting properties and (iii) applications of conjugated dendrimers in drug delivery nanodevices. With more studies to elucidate the structure–function relationship of ligand–dendrimer conjugates in transporting drugs, the conjugated dendrimers hold promise to facilitate targeted delivery and improve drug efficacy for discovery and development of modern pharmaceutics.
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Chen, Junjie, and Mark M. Banaszak Holl. "Dendrimer and dendrimer–conjugate protein complexes and protein coronas." Canadian Journal of Chemistry 95, no. 9 (September 2017): 903–6. http://dx.doi.org/10.1139/cjc-2017-0198.

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Dendrimers and dendrimer conjugates are widely employed for biological applications such as bio-imaging and drug delivery. Understanding the interaction between dendrimers and their biological environment is key to evaluating the efficacy and safety of these materials. Proteins can form an adsorbed layer, termed a “protein corona”, on dendrimers in either a non-specific or specific fashion. A tight-binding, non-exchangeable corona is defined as a “hard” corona, whereas a loosely bound, highly exchangeable corona is called a “soft” corona. Recent research indicates that small molecules conjugated to the polymer surface can induce protein structural change, leading to tighter protein–dendrimer binding and further protein aggregation. This “triggered” corona formation on dendrimer and dendrimer conjugates is reviewed and discussed along with the existing hard or soft corona model. This review describes the triggered corona model to further the understanding of protein corona formation.
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Zhang, Mengen, Jingyi Zhu, Yun Zheng, Rui Guo, Shige Wang, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, and Xiangyang Shi. "Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy." Pharmaceutics 10, no. 3 (September 19, 2018): 162. http://dx.doi.org/10.3390/pharmaceutics10030162.

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We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells. In this work, we covalently conjugated DOX onto the periphery of partially acetylated and folic acid (FA)-modified generation 5 (G5) PAMAM dendrimers through a pH-sensitive cis-aconityl linkage to form the G5.NHAc-FA-DOX conjugates. The formed dendrimer conjugates were well characterized using different methods. We show that DOX release from the G5.NHAc-FA-DOX conjugates follows an acid-triggered manner with a higher release rate under an acidic pH condition (pH = 5 or 6, close to the acidic pH of tumor microenvironment) than under a physiological pH condition. Both in vitro cytotoxicity evaluation and cell morphological observation demonstrate that the therapeutic activity of dendrimer-DOX conjugates against cancer cells is absolutely related to the DOX drug released. More importantly, the FA conjugation onto the dendrimers allowed a specific targeting to cancer cells overexpressing FA receptors (FAR), and allowed targeted inhibition of cancer cells. The developed G5.NHAc-FA-DOX conjugates may be used as a promising nanodevice for targeted cancer chemotherapy.
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Bahadoran, Azadeh, Hassan Moeini, Mohd Hair Bejo, Mohd Zobir Hussein, and Abdul Rahman Omar. "Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery." Journal of Pharmacy & Pharmaceutical Sciences 19, no. 3 (August 21, 2016): 325. http://dx.doi.org/10.18433/j3g31q.

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PURPOSE: In order to enhance cellular uptake and to facilitate transdermal delivery of DNA vaccine, polyamidoamine (PAMAM) dendrimers conjugated with HIV transactivator of transcription (TAT) was developed. METHODS: First, the plasmid DNA (pIRES-H5/GFP) nanoparticle was formulated using PAMAM dendrimer and TAT peptide and then characterized for surface charge, particle size, DNA encapsulation and protection of the pIRES-H5/GFP DNA plasmid to enzymatic digestion. Subsequently, the potency of the TAT-conjugated dendrimer for gene delivery was evaluated through in vitro transfection into Vero cells followed by gene expression analysis including western blotting, fluorescent microscopy and PCR. The effect of the TAT peptide on cellular uptake of DNA vaccine was studied by qRT-PCR and flow cytometry. Finally, the ability of TAT-conjugated PAMAM dendrimer for transdermal delivery of the DNA plasmid was assessed through artificial membranes followed by qRT-PCR and flow cytometry. RESULTS: TAT-conjugated PAMAM dendrimer showed the ability to form a compact and nanometre-sized polyplexes with the plasmid DNA, having the size range of 105 to 115 nm and a positive charge of +42 to +45 mV over the N/P ratio of 6:1(+/-). In vitro transfection analysis into Vero cells confirms the high potency of TAT-conjugated PAMAM dendrimer to enhance the cellular uptake of DNA vaccine. The permeability value assay through artificial membranes reveals that TAT-conjugated PAMAM has more capacity for transdermal delivery of the DNA compared to unmodified PAMAM dendrimer (P<0.05). CONCLUSIONS: The findings of this study suggest that TAT-conjugated PAMAM dendrimer is a promising non-viral vector for transdermal use.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
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Mendoza-Nava, Héctor, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Liliana Aranda-Lara, Erika Azorín-Vega, Enrique Morales-Avila, and Keila Isaac-Olivé. "177Lu-Dendrimer Conjugated to Folate and Bombesin with Gold Nanoparticles in the Dendritic Cavity: A Potential Theranostic Radiopharmaceutical." Journal of Nanomaterials 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/1039258.

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177Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim of this research was to synthesize 177Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold nanoparticles (AuNPs) in the dendritic cavity and to evaluate the radiopharmaceutical potential for targeted radiotherapy and the simultaneous detection of folate receptors (FRs) and gastrin-releasing peptide receptors (GRPRs) overexpressed in breast cancer cells. p-SCN-Benzyl-DOTA was conjugated in aqueous-basic medium to the dendrimer. The carboxylate groups of Lys1Lys3(DOTA)-bombesin and folic acid were activated with HATU and also conjugated to the dendrimer. The conjugate was mixed with 1% HAuCl4 followed by the addition of NaBH4 and purified by ultrafiltration. Elemental analysis (EDS), particle size distribution (DLS), TEM analysis, UV-Vis, and infrared and fluorescence spectroscopies were performed. The conjugate was radiolabeled using 177LuCl3 or 68GaCl3 and analyzed by radio-HPLC. Studies confirmed the dendrimer functionalization with high radiochemical purity (>95%). Fluorescence results demonstrated that the presence of AuNPs in the dendritic cavity confers useful photophysical properties to the radiopharmaceutical for optical imaging. Preliminary binding studies in T47D breast cancer cells showed a specific cell uptake (41.15±2.72%). 177Lu-dendrimer(AuNP)-folate-bombesin may be useful as an optical and nuclear imaging agent for breast tumors overexpressing GRPR and FRs, as well as for targeted radiotherapy.
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Seixas, Nalin, Bruno Ravanello, Ibrahim Morgan, Goran Kaluđerović, and Ludger Wessjohann. "Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH2 Core and Evaluation of Their Anticancer Activity." Pharmaceutics 11, no. 2 (February 1, 2019): 59. http://dx.doi.org/10.3390/pharmaceutics11020059.

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Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (i-Pr) and cationic (–NH2) or anionic (–COOH) groups. Standard viability assays were used to evaluate the anticancer potential of the water-soluble dendrimers against PC-3 prostate and HT-29 colon cancer cell lines, as well as non-cancerous mouse NIH3T3 fibroblasts. It could be demonstrated that the anticancer activity against PC-3 cells was considerably improved when both chlorambucil and –NH2 (cationic) groups were present on the dendrimer surface (1b). Additionally, this dendrimer showed activity only against the prostate cancer cells (PC-3), while it did not affect colon cancer cells and fibroblasts significantly. The cationic chlorambucil-dendrimer 1b blocks PC-3 cells in the G2/M phase and induces caspase independent apoptosis.
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Chun, Candy K. Y., and Richard J. Payne. "Synthesis of MUC1 Peptide and Glycopeptide Dendrimers." Australian Journal of Chemistry 62, no. 10 (2009): 1339. http://dx.doi.org/10.1071/ch09282.

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Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.
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Qiao, Shanlin, Ting Wang, Wei Huang, Jia-Xing Jiang, Zhengkun Du, Fa-Kuen Shieh, and Renqiang Yang. "Dendrimer-like conjugated microporous polymers." Polymer Chemistry 7, no. 6 (2016): 1281–89. http://dx.doi.org/10.1039/c5py01767j.

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Han, Shuqin, Tsogzolmaa Ganbold, Qingming Bao, Takashi Yoshida, and Huricha Baigude. "Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics." Polymers 10, no. 9 (September 18, 2018): 1034. http://dx.doi.org/10.3390/polym10091034.

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Sugars containing cationic polymers are potential carriers for in vitro and in vivo nucleic acid delivery. Monosaccharides such as glucose and galactose have been chemically conjugated to various materials of synergistic poly-lysine dendrimer systems for efficient and biocompatible delivery of short interfering RNA (siRNA). The synergistic dendrimers, which contain lipid conjugated glucose terminalized lysine dendrimers, have significantly lower adverse impact on cells while maintaining efficient cellular entry. Moreover, the synergistic dendrimers complexed to siRNA induced RNA interference (RNAi) in the cells and profoundly knocked down green fluorescence protein (GFP) as well as the endogenously expressing disease related gene Plk1. The new synergic dendrimers may be promising system for biocompatible and efficient siRNA delivery.
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Geiger, Brett C., Sheryl Wang, Robert F. Padera, Alan J. Grodzinsky, and Paula T. Hammond. "Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis." Science Translational Medicine 10, no. 469 (November 28, 2018): eaat8800. http://dx.doi.org/10.1126/scitranslmed.aat8800.

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Osteoarthritis is a debilitating joint disease affecting nearly 30 million people for which there are no disease-modifying therapies. Several drugs that have failed clinical trials have shown inefficient and inadequate delivery to target cells. Anabolic growth factors are one class of such drugs that could be disease-modifying if delivered directly to chondrocytes, which reside deep within dense, anionic cartilage tissue. To overcome this biological barrier, we conjugated a growth factor to a cationic nanocarrier for targeted delivery to chondrocytes and retention within joint cartilage after direct intra-articular injection. The nanocarrier uses reversible electrostatic interactions with anionic cartilage tissue to improve tissue binding, penetration, and residence time. Amine terminal polyamidoamine (PAMAM) dendrimers were end functionalized with variable molar ratios of poly(ethylene glycol) (PEG) to control surface charge. From this small family of variably PEGylated dendrimers, an optimal formulation showing 70% uptake into cartilage tissue and 100% cell viability was selected. When conjugated to insulin-like growth factor 1 (IGF-1), the dendrimer penetrated bovine cartilage of human thickness within 2 days and enhanced therapeutic IGF-1 joint residence time in rat knees by 10-fold for up to 30 days. In a surgical model of rat osteoarthritis, a single injection of dendrimer–IGF-1 rescued cartilage and bone more effectively than free IGF-1. Dendrimer–IGF-1 reduced width of cartilage degeneration by 60% and volumetric osteophyte burden by 80% relative to untreated rats at 4 weeks after surgery. These results suggest that PEGylated PAMAM dendrimer nanocarriers could improve pharmacokinetics and efficacy of disease-modifying osteoarthritis drugs in the clinic.
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Dissertations / Theses on the topic "Conjugated dendrimer"

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Komurcu, Ramazan. "TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1196653318.

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Thomsen, Elizabeth Alice. "Characterisation of materials for organic photovoltaics." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/462.

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Nicolini, Anthony Michael. "N-isopropyl-acrylamide conjugated polyglycerol as a delivery vehicle for in vitro sirna transfection." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41124.

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Gene expression knockdown using RNA interference has dramatically altered the ability to silence target genes without the need for a creation of a genetic knockout. The pitfalls surrounding successful siRNA gene expression knockdown fall in the broad category of delivery. This work focuses on the use of N-isopropyl-acrylamide conjugated polyglycerol (PGNIPAM) as a novel cationic vector of in vitro and possible in vivo delivery of siRNA. The hyper-branched structure of the PGNIPAM molecule bears a biocompatible core with cationic subunits on the surface, providing a less toxic alternative to other cationic polymers used in the past. Further PGNIPAM shows excellent binding and release characteristics over other comparable molecules and systems. Activity of the siRNA requires access to the cell cytoplasm, which in turn requires passage of the siRNA through the cell membrane and release into the internal environment with no degradation. PGNIPAM has shown the ability to traverse the endocytic pathway and release the siRNA directly into the cytoplasm where it can interact with cellular machinery. Knockdown of known oncogene survivin was observed in vitro both through mRNA expression reduction as well as through protein reduction in MDA-MB-231 human breast cancer cells. Additionally, early stage animal work with a human breast cancer model shows positive results for coupled treatment of tumors using siRNA against survivin and doxorubicin, an anticancer drug. PGNIPAM offers a safer alternative to other cationic delivery systems and has shown improvement over standard modes of knockdown from commercial products.
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Richardson, Scott. "The fabrication and lithography of conjugated polymer distributed feedback lasers and development of their applications." Thesis, St Andrews, 2007. http://hdl.handle.net/10023/401.

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Vukojicic, Petar. "Affitin-dendrimer conjugates for multivalency-enhanced targeting." Thesis, Nantes, 2019. http://www.theses.fr/2019NANT1002/document.

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Les nanoparticules décorées de ligands de ciblage sont des dispositifs puissants développés pour servir d'outils théranostiques efficaces contre des maladies graves comme le cancer ou les maladies infectieuses. En raison des limitations importantes des anticorps en tant que ligands de ciblage, comme une grande taille et une faible stabilité, les protéines d'affinité modifiées à façon offrent une alternative intéressante pour la fonctionnalisation des nanoparticules. Les Affitines sont de petites protéines thermiquement et chimiquement stables, dérivées d'une famille de protéines d’archées de 7 kDa liant l'ADN, dont la spécificité et l'affinité pour leurs cibles sont comparables à celles des anticorps. Les dendrimères de l'acide gallique-triéthylèneglycol (GATG) sont des macromolécules monodispersées, synthétiques, globulaires, en forme d'arbre, préparées de façon itérative (générations) permettant une présentation multivalente des ligands de ciblage. L'objectif de ce travail de thèse est de combiner les propriétés de ciblage des Affitines et la polyvalence des dendrimères pour obtenir des conjugués Affitines-dendrimères pour des applications biomédicales. Le premier objectif était de mettre au point une méthode de conjugaison orientée pour incorporer des Affitines ciblant Staphylococcus aureus (S. aureus) et un traceur fluorescent pour la détection et l'imagerie, puis de les caractériser en termes de taille, d’hétérogénéité, de composition et d’affinité. Le deuxième objectif était d'évaluer leur potentiel à moduler des comportements multicellulaires complexes, comme l'agglutination et la formation de biofilms de S. aureus grâce aux interactions multivalentes implémentées
Smart targeted nanoparticles are powerful devices developed to serve as efficient theranostic tools against severe disorders such as cancer or infectious diseases. Due to important limitations of antibodies as targeting ligands, such as large size and low stability, engineered affinity binding proteins offer an attractive alternative for nanoparticle functionalization. Affitins are small, thermally and chemically stable proteins derived from an archaeal 7 kDa DNA-binding family, with specificity and affinity for their targets comparable to that of antibodies. Gallic acid-triethylene glycol (GATG) dendrimers are monodisperse, synthetic globular tree-like macromolecules prepared in a stepwise fashion (generations) allowing multivalent presentation of targeting ligands. The aim of this project is to combine the targeting properties of Affitins and the versatility and multivalency of dendrimers to obtain Affitin-dendrimer conjugates for biomedical applications. The first goal of this work was to develop a site-specific conjugation method to incorporate Affitins targeting Staphylococcus aureus (S. aureus) and a fluorescent dye for detection and imaging, and then to thoroughly characterize them in terms of size, heterogeneity, composition and affinity. The second goal was to assess the potential of these conjugates to modulate complex multicellular behaviors, such as agglutination and biofilm formation of S. aureus due to enhanced multivalent interactions
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Andrews, Shannon. "FOLATE CONJUGATED DENDRIMERS FOR TARGETED ANTICANCER THERAPY." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3497.

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Anticancer therapeutics are often limited to suboptimal doses due to their lack of selectivity for tumor cells and resultant damage to healthy tissue. These limitations motivated researchers to develop tumor-specific delivery systems for improved therapeutic efficacy and reduced unintended cytotoxicity. Polyamidoamine dendrimers offer an ideal platform for designing targeted therapeutics with tunable characteristics that optimize pharmacokinetic behavior and targeting specificity. Ligand conjugation to dendrimer provides the biochemical interaction necessary to activate tumor-specific receptors for receptor-mediated endocytosis and effective internalization of polyplexes. Tumor-specific receptors overexpressed in carcinomas, like folate receptor-alpha (FOLRα), are targeted by ligand-conjugated dendrimer to allow enhanced internalization of dendrimer and its therapeutic cargo. We examined the cellular trafficking dynamics and potential of folate-conjugated dendrimer for nucleic acid delivery in vitro. Results show folate-conjugation to G4 PAMAM dendrimer (G4FA) confers enhanced uptake in FOLRα-positive tumor cells. Cells internalize G4FA in a receptor-dependent manner with specificity for FOLRα-positive tumor cells.
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Halim, Mounir. "Light-emission from conjugated dendrimers and polymers." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4297/.

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This thesis reports the photophysical and electroluminescence studies undertaken on two types of material: polymeric and dendritic. The dendritic architecture is a recent concept adopted to develop new materials for light-emitting diodes. The dendritic structure offers a combination of properties of both polymers and small organic molecules whilst having their own interesting characteristic of optimising processibility, charge transport, and optical properties independently. The dendritic structure consists of functional surface groups, conjugated dendrons and a conjugated core. Initial optical (absorption and photoluminescence) studies revealed that the dendrimer emission originates from the core and is independent of excitation wavelength. This was investigated further in distyrylbenzene based dendrimers where the effect of dendrimer generation number on photoluminescence and electroluminescence properties was studied. All dendrimers emit blue electroluminescence with, in some cases, reasonable electroluminescence quantum efficiency in the range of 0.09 % and brightness up to 150 Cd m(^-2). Having established that the furmel effect, where excitation is successfully transferred to the dendrimer core in both PL and EL, different chromophores were incorporated in the dendrimer structure. Colour control was thus demonstrated in EL devices of the different dendrimers, showing the possibility of using a large number of chromophores in a processible form for EL applications. Conjugated polymers were also studied to investigate the nature of the emitting species (poly(p-pyridine)) and the effect of side- chains (poly(p-phenylenevinylene)). In poly(p-pyridine) the emission was found to be strongly dependent on pyridyl ring rotation affecting the emission and its quantum yield while the side-chains in the poly(p-phenylenevinylene) derivatives were found to affect polymer properties such as degree of conversion of non-conjugated to conjugated polymer. The PL quantum yield system was set-up and proved useful in assessing synthesis of new materials.
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Wilbers, Derik. "Preparation, characterization and applications of macrocycle-dendrimer conjugates." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85568.

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Thesis (MSc)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: In this thesis we describe various attempts at incorporating macrocycles into dendritic architectures to form macrocycle-dendrimer conjugates with the aim of preparing materials that would exhibit properties that are more than the sum of the constituent parts, in this case macrocycles and dendrimers. A further aim was the synthesis and characterization of metallodendrimers based on such scaffolds and to test these as catalyst precursors in the catalytic oxidation of alcohols. The synthesis of two different types of conjugate systems was attempted; viz. dendrimers functionalized with macrocycles on the peripheries and dendrimers with macrocyclic cores. The synthesis of conjugate systems based on cyclam as the macrocycle was attempted. This required the mono functionalization of cyclam with a linker molecule capable of further reaction with the functional groups at the periphery of commercially available N,N,N,N-tetrakis(3-aminopropyl)-1,4-butanediamine dendrimer. Several approaches were taken in trying to make such conjugate systems but they were not entirely successful. One of the major issues was the final deprotection step, of the Boc-protected cyclam units which proved difficult in our hands. Another approach to prepare the target conjugates involved the use of click chemistry in order to synthesize a dendrimer with an aromatic core and cyclam peripheries. A dendrimer with Boc-protected cyclam peripheries that are bonded through triazole groups to the aromatic core was synthesized. However, subsequent attempts at de-protection of the cyclam functionalities of this conjugate failed to yield the pure de-protected dendrimer. Greater success was achieved with the preparation of a dendrimer with a macrocyclic core. A cyclam cored dendrimer with salicylaldimine peripheries was successfully synthesized and characterized. This dendritic ligand was complexed to Cu(II), Ni(II) and Zn(II) metal ions respectively to form a series of new metallodendrimers. These metallodendrimers were fully characterized using a range of analytical techniques including FT-IR spectroscopy, mass spectrometry, elemental analysis, thermogravimetric analysis, magnetic susceptibility measurements and NMR spectroscopy where appropriate. The Cu(II) and Ni(II) metallodendrimers were tested as catalyst precursors in the catalytic oxidation of benzyl alcohol to benzaldehyde. The catalytic system consisted of the appropriate metallodendrimer, the free radical, 2,2,6,6-tetramethylpiperidinyl- 1-oxyl (TEMPO) and O2 as the oxidant. The reaction parameters, namely the nature of the solvent, catalyst loading, substrate concentration and reaction temperature were sequentially optimized to achieve the best catalytic efficiency. The Cu(II) catalyst precursor exhibited relatively high catalytic activity and achieved TOF’s between 40 and 30 when operating under the optimized conditions, while the Ni(II) catalytic system showed very poor catalytic activity.
AFRIKAANSE OPSOMMING: In hierdie tesis beskryf ons pogings om makroringe in die dendritiese argitektuur te inkorporeer om makroring-dendrimeer gekonjugeerdes te vorm met die hoop dat sulke molekules eienskappe sal toon wat meer is as die somtotaal van die afsonderlike eenhede. ‘n Verdere doel was die sintese en karakterisering van metallodendrimere gebaseer op sulke draers sowel as die toetsing van hierdie molekules as pre-katalisore in die katalitiese oksidasie van alkohole. Pogings tot die sintese van twee verskillende tipes makroring-dendrimeer gekonjugeerdes word beskryf naamlik, dendritiese ligande met makroringe by die buiterand sowel as dendritiese ligande met ‘n makroring as kern word bespreek. Die sintese van makroring-dendrimeer gekonjugeerdes gebasseer op die makroring cyclam word beskryf. Hierdie sintese vereis die gebruik van ‘n monogefunksioneerde cyclam wat ‘n gepaste koppelingsgroep besit. Hierdie koppelingsgroep kan dan verder met funksionele groepe op die oppervlak van die kommersieel beskikbare DAB-dendrimeer reageer. Verskeie pogings is aangewend om sulke gekonjugeerde stelsels te sintetiseer maar hierdie pogings was nie volkome suksesvol nie. ‘n Groot uitdaging was die gebruik en gevolglike latere verwydering van beskermende groepe soos Boc. ‘n Ander benadering het gebruik gemaak van “click” chemie met die doel om ‘n dendrimeer bestaande uit ‘n aromatiese kern en cyclam periferie te vorm. ‘n Dendrimeer met Boc beskermde cyclam eenhede op die buiterand geheg aan ‘n aromatiese kern deur triasool groepe is gesintetiseer. Die verwydering van die beskermende groepe geheg aan die cyclam eenhede was egter weereens ‘n probleem en hierdie metode kon nie die suiwer dendrimeer lewer nie. Groter sukses is behaal met die sintese van ‘n dendrimeer met ‘n cyclam kern en salisielaldimien periferieë. Die dendritiese ligand is vervolgens met metaalsoute van Cu(II), Ni(II) en Zn(II) gereageer om verskeie multikern metaalkomplekse te vorm. Die metaalkomplekse is volledig gekarakteriseer deur verskeie analitiese tegnieke insluitende infrarooi spektroskopie, massa spektrometrie, termografiese analiese, mikroanaliese asook KMR spektroskopie waar moontlik. Die Cu(II) en Ni(II) metaalkomplekse is geëvalueer as pre-katalisatore in die katalitiese oksidasie van alkohole. Hierdie katalitiese sisteem bestaan uit die metaalkompleks, die radikaal TEMPO en molekulêre suurstof. Die invloed van verskeie reaksie- parameters soos die tipe oplosmiddel, die hoeveelheid katalisator, die konsentrasie van die alkohol asook die temperatuur is ondersoek. Gevolglik is die optimale kondisies bepaal om die hoogste opbrengs van bensaldehied te lewer. Die Cu(II) kompleks het ‘n relatief hoë omset van bensielalkohol na bensaldehied getoon met omset frekwensie waardes tussen 30 en 40 onder die optimale kondisies. Die Ni(II) kompleks het egter swak aktiwiteit getoon vir hierdie transformasie.
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Atas, Evrim. "Ultrafast time resolved excitation dynamics in conjugated dendrimers." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013101.

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Elouzi, Abdurrahim A. "Tumour targeting of gene expression using hyaluronic acid - polypropylenimine dendrimer conjugates." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424350.

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Books on the topic "Conjugated dendrimer"

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Francqui, Colloquium (4th 1998 Brussels Belgium). Conjugated oligomers, polymers, and dendrimers: From polyacetylene to DNA : proceedings of the Fourth Francqui Colloqium, 21-23 October 1998, Brussels. Paris: De Boeck Université, 1999.

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Zhang, Jie. Hemoglobin and dendrimer conjugates. 2005.

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Conjugated oligomers, polymers, and dendrimers: From polyacetylene to DNA : Proceedings of the Fourth Francqui Colloqium, 21-23 October 1998, Brussels ... Francqui = Francqui scientific library). De Boeck Universite, 1999.

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Book chapters on the topic "Conjugated dendrimer"

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Wong, Pamela T., Kumar Sinniah, and Seok Ki Choi. "Riboflavin-Conjugated Multivalent Dendrimer Platform for Cancer-Targeted Drug and Gene Delivery." In Bioactivity of Engineered Nanoparticles, 145–71. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5864-6_7.

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Sellinger, Alan, and Tianlei Zhou. "Conjugated Dendrimers." In Encyclopedia of Polymeric Nanomaterials, 412–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-29648-2_94.

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Sellinger, Alan, and Tianlei Zhou. "Conjugated Dendrimers." In Encyclopedia of Polymeric Nanomaterials, 1–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36199-9_94-1.

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Turrin, Cédric-Olivier, and Anne-Marie Caminade. "Dendrimer Conjugates for Drug Delivery." In Dendrimers, 437–61. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch18.

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Bordeianu, Catalina, and Delphine Felder-Flesch. "Chapter 2 Dendrimer-Nanoparticle Conjugates in Nanomedicine." In Dendrimers in Nanomedicine, 23–76. Penthouse Level, Suntec Tower 3, 8 Temasek Boulevard, Singapore 038988: Pan Stanford Publishing Pte. Ltd., 2016. http://dx.doi.org/10.1201/9781315364513-3.

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Howell, Bob A., Daming Fan, and Leela Rakesh. "Nanoscale Dendrimer-Platinum Conjugates as Multivalent Antitumor Drugs." In Inorganic and Organometallic Macromolecules, 269–94. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-72947-3_11.

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Khosroshahi, M. E., M. Tajabadi, Sh Bonakdar, and V. Asgari. "Synthesis and Characterization of SPION Functionalized third Generation dendrimers Conjugated by Gold Nanoparticles and Folic acid for Targeted Breast Cancer Laser Hyperthermia: An Invitro-assay." In IFMBE Proceedings, 823–26. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19387-8_201.

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Pooja, Deep, Ramakrishna Sistla, and Hitesh Kulhari. "Dendrimer-drug conjugates." In Design of Nanostructures for Theranostics Applications, 277–303. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-813669-0.00007-5.

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Park, Jong-Sang, Tae-il Kim, and Joon Sig Choi. "Poly(ethylene glycol)-Conjugated Cationic Dendrimers." In Polymeric Gene Delivery. CRC Press, 2004. http://dx.doi.org/10.1201/9780203500477.ch10.

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C. García-Martínez, Joaquín, Enrique Díez-Barra, and Julián Rodríguez-López. "Conjugated Dendrimers with Poly(Phenylenevinylene) and Poly(Phenyleneethynylene) Scaffolds." In Advances in Organic Synthesis, 185–234. BENTHAM SCIENCE PUBLISHERS, 2013. http://dx.doi.org/10.2174/9781608054800113050006.

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Conference papers on the topic "Conjugated dendrimer"

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Ashford, Marianne B., Srividya B. Balachander, Lorraine Graham, Iain Grant, Francis D. Gibbons, Kathryn J. Hill, Alexander R. Harmer, et al. "Abstract 1718: Design and optimization of a dendrimer-conjugated dual Bcl-2/Bcl-xLinhibitor, AZD0466, with improved therapeutic index." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1718.

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Wang, Yang, Bill McBride, David M. Goldenberg, and Chien-Hsing Chang. "Abstract 4445: Novel antibody-dendrimer conjugates efficiently complex plasmid DNA." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4445.

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Melinger, Joseph S., Dale McMorrow, William T. Lotshaw, Yongchun Pan, and Zhonghua Peng. "Two-photon absorption in conjugated phenylacetylene dendrimers with unsymmetrical branching." In Nonlinear Optics: Materials, Fundamentals and Applications. Washington, D.C.: OSA, 2004. http://dx.doi.org/10.1364/nlo.2004.wd13.

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Rebane, Aleksander, Niklas Christensson, Mikhail Drobizhev, Yuriy Stepanenko, and Charles W. Spangler. "Quantum interference by femtosecond multi-photon absorption in conjugated dendrimers." In Optics & Photonics 2005, edited by A. Todd Yeates. SPIE, 2005. http://dx.doi.org/10.1117/12.617308.

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Markham, Jonathan P., Thomas D. Anthopoulos, Ebinazar B. Namdas, Shih-Chun Lo, Gary J. Richards, Michael J. Frampton, Oleg V. Salata, Paul L. Burn, and Ifor D. Samuel. "Conjugated dendrimers: a modular approach to materials for full-color displays." In Optical Science and Technology, SPIE's 48th Annual Meeting, edited by Zakya H. Kafafi and Paul A. Lane. SPIE, 2004. http://dx.doi.org/10.1117/12.512062.

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Neelov, Igor, Elena Popova, and Dilorom Khamidova. "Complexes and conjugates of lysine dendrimer with therapeutic tetrapeptides. Molecular dynamics simulation." In MATHEMATICAL METHODS AND COMPUTATIONAL TECHNIQUES IN SCIENCE AND ENGINEERING II. Author(s), 2018. http://dx.doi.org/10.1063/1.5045434.

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Rebane, Aleks, Nikolay Makarov, Mikhail Drobizhev, Charles W. Spangler, Aijun Gong, and Fanqing Meng. "Broad bandwidth near-IR two-photon absorption in conjugated porphyrin-core dendrimers." In Photonic Devices + Applications, edited by Jean-Michel Nunzi. SPIE, 2007. http://dx.doi.org/10.1117/12.734475.

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Torres-Pérez, Sergio Andrés, María del Pilar Ramos-Godínez, and Eva Ramón-Gallegos. "Effect of methotrexate conjugated PAMAM dendrimers on the viability of breast cancer cells." In 1ST INTERNATIONAL CONFERENCE ON BIOINFORMATICS, BIOTECHNOLOGY, AND BIOMEDICAL ENGINEERING (BIOMIC 2018). Author(s), 2019. http://dx.doi.org/10.1063/1.5095929.

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Satsangi, A., SS Roy, RK Satsangi, RK Vadlamudi, and JL Ong. "Abstract P4-16-10: A novel paclitaxel-dendrimer conjugate demonstrates better efficacy in breast cancer models." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p4-16-10.

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Dichwalkar, Tanmay, Samhita Bapat, Priya Pancholi, V. K. Yellepeddi, and Vikas Sehdev. "Abstract 2200: Omega-3 fatty acid conjugated paclitaxel dendrimers exhibit enhanced anticancer activity in various preclinical models of gastrointestinal cancers." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2200.

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