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Journal articles on the topic 'Conjugated frequency analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Liu, C. C., Terry B. J. Kuo, and Cheryl C. H. Yang. "Effects of estrogen on gender-related autonomic differences in humans." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 5 (2003): H2188—H2193. http://dx.doi.org/10.1152/ajpheart.00256.2003.

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Our previous studies demonstrated that premenopausal women have dominant vagal and subordinate sympathetic activity compared with age-matched men. This study was designed to investigate the role of estrogen in gender-related autonomic differences. We evaluated the heart rate variability of four healthy groups: agedmatched postmenopausal women without hormone replacement therapy (PM), postmenopausal women on conjugated estrogen replacement therapy (PME), men, and non-age-matched premenopausal women (PreM). Frequency-domain analysis of short-term and stationary R-R intervals was performed to eva

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Ueda, Yuichiro, Toshihiko Sato, Ryosuke Nakamura, et al. "Evaluation of regenerated tracheal cilia function on a collagen-conjugated scaffold in a canine model." Interactive CardioVascular and Thoracic Surgery 31, no. 5 (2020): 644–49. http://dx.doi.org/10.1093/icvts/ivaa167.

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Abstract OBJECTIVES It is unclear whether the movement and function of the regenerated cilia on collagen-conjugated artificial trachea are the same as those of normal cilia. This study assessed the ciliary beat frequency (CBF) and ciliary transport functions (CTFs) of regenerated cilia in a canine model. METHODS A tracheal defect introduced into the anterior portion of the cervical trachea of an adult beagle dog was covered with a collagen-conjugated prosthesis. Two months later, the trachea was harvested along the long axis, both from normal and regenerated regions. The cilia were stained wit

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Araten, David, Katie J. Sanders, Dan Anscher, Leah Zamechek, Stephen P. Hunger, and Sherif Ibrahim. "A High Frequency of Blasts with the PNH Phenotype in Patients with ALL." Blood 114, no. 22 (2009): 1575. http://dx.doi.org/10.1182/blood.v114.22.1575.1575.

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Abstract Abstract 1575 Poster Board I-601 It has been proposed that if more than 2 mutations are required for leukemia to arise, then an elevation in the mutation rate would be necessary for these mutations to coincide in the same cell, based on the rarity of spontaneous mutations (Loeb 1991). Hypermutability could occur transiently, for example, due to mutagens, or permanently, due to inactivation of repair pathways. Genome-wide analysis has indicated that in acute lymphoblastic leukemia (ALL), more than 2 somatic mutations are often found (Mullighan et al 2007), suggesting that hypermutabili

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Beck, Richard A., Scott Kambiss, and James W. Bass. "The Retreat of Hemophilus Influenzae Type B Invasive Disease: Analysis of an Immunization Program and Implications for OTO-HNS." Otolaryngology–Head and Neck Surgery 109, no. 4 (1993): 712–21. http://dx.doi.org/10.1177/019459989310900413.

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Hemophilus influenzae type b (Hib) is the most common cause of bacterial meningitis among children under 5 years old. Hib is also responsible for other invasive diseases including epiglottitis, cellulitis, sepsis, pneumonia, and osteomyelitis. A child's cumulative risk of systemic Hib disease during the first 5 years of life is approximately 1 in 200. A polysaccharide Hib vaccine was first marketed in 1985, and newer, more effective conjugated vaccines have been licensed since 1987. Immunization schedules have Included Increasingly younger children. No studies have been published that analyze

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Ding, Jiang, Aiping Deng, Liwei Liu, and Mengen Lu. "Dynamic Analysis of Line Gear Pair Based on Numerical Manifold Method." Strojniški vestnik – Journal of Mechanical Engineering 67, no. 6 (2021): 275–86. http://dx.doi.org/10.5545/sv-jme.2021.7118.

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As a kind of tiny gear based on space curve meshing theory, the line gear is very suitable for miniaturized machines due to its compact size and low weight. However, the line gear usually suffers from serious vibration problems since its line teeth are designed as twisted three-dimensional cantilevers to provide conjugated meshing curves. A dynamic model of the line gear pair is established in this paper using the numerical manifold method (NMM) to alleviate its vibration conditions, which can simultaneously provide mathematical and physical covers. The displacement function is first derived f

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Serizawa, Takahiro, Takako Terui, Tatsuya Kagemoto, et al. "Real-time measurement of the length of a single sarcomere in rat ventricular myocytes: a novel analysis with quantum dots." American Journal of Physiology-Cell Physiology 301, no. 5 (2011): C1116—C1127. http://dx.doi.org/10.1152/ajpcell.00161.2011.

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As the dynamic properties of cardiac sarcomeres are markedly changed in response to a length change of even ∼0.1 μm, it is imperative to quantitatively measure sarcomere length (SL). Here we show a novel system using quantum dots (QDs) that enables a real-time measurement of the length of a single sarcomere in cardiomyocytes. First, QDs were conjugated with anti-α-actinin antibody and applied to the sarcomeric Z disks in isolated skinned cardiomyocytes of the rat. At partial activation, spontaneous sarcomeric oscillations (SPOC) occurred, and QDs provided a quantitative measurement of the leng

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Zhao, Sicheng, Mathias Dietzel, and Steffen Hardt. "Faraday instability of a liquid layer on a lubrication film." Journal of Fluid Mechanics 879 (September 27, 2019): 422–47. http://dx.doi.org/10.1017/jfm.2019.684.

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The Faraday instability in a system of two conjugated immiscible liquid layers with disparate thicknesses is investigated. The top layer is relatively thick and undergoes short-wavelength instabilities, while the bottom layer is thin and undergoes long-wavelength instabilities. The two layers are coupled by the kinematic and dynamic relations at the interface. Through linear stability analysis, a lubrication effect, which significantly reduces the destabilization threshold, is identified. Especially when the vibration frequency is low, the lubrication effect is seen to influence the transition

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Zhao, Shoujun, Keqin Chen, Xiaosha Zhang, et al. "A High-Order Load Model and the Control Algorithm for an Aerospace Electro-Hydraulic Actuator." Actuators 10, no. 3 (2021): 53. http://dx.doi.org/10.3390/act10030053.

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It is difficult to describe precisely, and thus control satisfactorily, the dynamics of an electro-hydraulic actuator to drive a high thrust liquid launcher engine, whose structural resonant frequency is usually low due to its heavy inertia and complicated mass distribution, let alone one to drive a heavy kerolox engine with high-order dynamics. By transforming classic control block diagrams, a baseline two-mass-two-spring load model and a normalized actuator-engine system model were developed for understanding the basic physics and methodology, where a fourth-order transfer function is used t

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Liu, Jie, Tracy J. Ruckwardt, Man Chen, Teresa R. Johnson, and Barney S. Graham. "Characterization of Respiratory Syncytial Virus M- and M2-Specific CD4 T Cells in a Murine Model." Journal of Virology 83, no. 10 (2009): 4934–41. http://dx.doi.org/10.1128/jvi.02140-08.

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ABSTRACT CD4 T cells have been shown to play an important role in the immunity and immunopathogenesis of respiratory syncytial virus (RSV) infection. We identified two novel CD4 T-cell epitopes in the RSV M and M2 proteins with core sequences M213-223 (FKYIKPQSQFI) and M227-37 (YFEWPPHALLV). Peptides containing the epitopes stimulated RSV-specific CD4 T cells to produce gamma interferon (IFN-γ), interleukin 2 (IL-2), and other Th1- and Th2-type cytokines in an I-Ab-restricted pattern. Construction of fluorochrome-conjugated peptide-I-Ab class II tetramers revealed RSV M- and M2-specific CD4 T-

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Tedla, Getachew, Jesse Plotkin, Anthony Dellinger, and Christopher Kepley. "Design and Testing of Dual-Targeted Gd3N@C80-Containing Glioblastoma Theranostics." Journal of Nanomaterials 2019 (March 3, 2019): 1–13. http://dx.doi.org/10.1155/2019/1242930.

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The majority of the malignant brain tumors are gliomas with glioblastoma being the most common and aggressive type. Due to its extreme infiltrative nature and higher occurrence frequency, finding new glioblastoma therapeutics and diagnostics is a high priority. In line with this, we previously synthesized a glioblastoma-targeting theranostic that images and delivers a therapeutic payload of doxorubicin (DXR) to human xenograft tumors. Herein, a dual-targeted theranostic is synthesized on the hypothesis that targeting multiple receptors would enhance delivery precision. Doxorubicin and endo-ful

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Ayuso, Pedro, Megan Neary, Justin Chiong, and Andrew Owen. "Meta-analysis of the effect of CYP2B6, CYP2A6, UGT2B7 and CAR polymorphisms on efavirenz plasma concentrations." Journal of Antimicrobial Chemotherapy 74, no. 11 (2019): 3281–90. http://dx.doi.org/10.1093/jac/dkz329.

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Abstract Background Efavirenz primary metabolism is catalysed by CYP2B6 with minor involvement of CYP2A6. Subsequently, phase I metabolites are conjugated by UGT2B7, and constitutive androstane receptor (CAR) has been shown to transcriptionally regulate many relevant enzymes and transporters. Several polymorphisms occurring in the genes coding for these proteins have been shown to impact efavirenz pharmacokinetics in some but not all studies. Objectives A meta-analysis was performed to assess the overall effect of CYP2B6 rs3745274, CYP2A6 (rs28399454, rs8192726 and rs28399433), UGT2B7 (rs28365

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Doratotaj, Behzad, Leah B. Zamechek, Kenneth B. Hymes, and David J. Araten. "Analysis of the mutation rate in lymphocytes derived from patients with cutaneous T-cell neoplasms using the PIG-a gene." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21082-e21082. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21082.

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e21082 Background: It has been proposed that genomic instability may account for the high number of mutations observed in cancer. Inherited mutations in repair genes might play a role; alternatively, hypermutability may be the result of mutagens, or may be limited to a specific pre-malignant population. Here we have investigated the hypothesis that cutaneous T cell neoplasms might be associated with constitutional hypermutability, using an assay based on the PIG-A gene. A broad spectrum of mutations can inactivate PIG-A, which is X-linked; thus, only one mutation is required to produce the PIG

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Calheiros, Luiz Arthur, Eliza Y. S. Kimura, Manuella S. S. Almeida, et al. "High Frequency of Aberrant Phenotype in Multiple Myeloma Patients Detected by Multiparametric Flow Cytometry." Blood 104, no. 11 (2004): 4862. http://dx.doi.org/10.1182/blood.v104.11.4862.4862.

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Abstract Multiple Myeloma (MM) is a B cell lymphoproliferative disease with clonal plasma cell accumulation in bone marrow. Multiparametric flow cytometry (MFC) is an usefull tool to distinguish MM cells from normal plasma cells. Normal plasma cells are characterized by the expression of CD19+, CD45++, CD38++, CD138++, cytoplasmic immunoglobulin light chains (κ and λ) and CD56- while most MM plasma cells lose CD19, CD45 and gain CD56. In addition, many other antigens may be expressed by myeloma cells such as myeloid or lymphoid lineage associated antigens and these abnormal antigen expression

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Mishlanov, V. Ju, I. V. Shubin, K. N. Bekker, A. V. Katkova, and E. P. Koshurnikova. "Chronic obstructive pulmonary disease patients electronic register analysis: the effectiveness of patient’s dynamic follow up and evaluation of treatment program." Terapevticheskii arkhiv 91, no. 1 (2019): 78–83. http://dx.doi.org/10.26442/00403660.2019.01.000034.

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In the last few years new informatics methods were implemented in medicine and allowed to create big data including individual clinical markers of every patient. It is suggested that clinical electronic patient’s register analysis will present accurate information about different treatment programs effectiveness, including those whose effectiveness is not still proved today. The aim of the study. To estimate the effectiveness of clinical patients register implementation as well as to analyze different treatment and prophylactic programs on chronic obstructive pulmonary disease (COPD) patients’

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David, Serge, Michel Gourdji, Lucien Guibé, and Alain Péneau. "Chlorine Substituted Acetic Acids and Salts. Effect of Salification on Chlorine-35 NQR." Zeitschrift für Naturforschung A 51, no. 5-6 (1996): 611–19. http://dx.doi.org/10.1515/zna-1996-5-640.

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Abstract The NQR of a quadrupolar probe nucleus is often used to investigate the effect of substituent in molecules. The inductive effect, based on a partial charge migration along the molecular skeleton is the only one present in saturated aliphatics, the conjugative effect appearing in conjugated molecules, especially aromatics. As the stepwise charge migration mechanism, formerly used to explain the inductive effect, is now believed obsolete, we have wanted to reexamined the case of chlorine substituted acetic acids and salts. The data in literature was extended by observing reso-nances and

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Rico- Lombana, Alejandra Rico Lombana, Jose Mateus, Paola Lasso, John Mario González, Concepción Judith Puerta, and Adriana Cuéllar. "Expression of inhibitory receptors on CD4+ and CD8+ T cells from healthy Colombian donors." Universitas Scientiarum 17, no. 1 (2012): 35. http://dx.doi.org/10.11144/javeriana.sc17-1.eoir.

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<p>T cell activation involves positive cellular signals that promote effector functions and negative signals that contribute to the regulation of these responses. These regulatory signals are generated upon activation of receptors on T cells that include CD160, 2B4, Programmed Death-1 and CTLA-4. <strong>Objective</strong>. To evaluate the expression of inhibitory receptors like CD160, 2B4, Programmed Death-1 and CTLA-4 on CD4+ and CD8+ T cells from healthy Colombian donors. <strong>Materials and methods</strong>. Peripheral blood mononuclear cells from 30 healthy

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Milner, T. E., G. Cadoret, L. Lessard, and A. M. Smith. "EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive." Journal of Neurophysiology 73, no. 6 (1995): 2568–77. http://dx.doi.org/10.1152/jn.1995.73.6.2568.

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1. The effects of intraperitoneal injections of 10 mg/kg harmaline were tested in normal mice and three strains of cerebellar mutant mice with Purkinje cell degeneration. Ten normal (wild-type) mice (+/+), as well as five lurcher (lc/+), six nervous (nr/nr), and eight Purkinje cell degeneration (pcd/pcd) mutants were implanted with chronic electromyogram (EMG) electrodes in the hamstring and quadriceps muscle groups of the right hindlimb. 2. EMGs were recorded in each of the mice during spontaneous activity before and after intraperitoneal injections of 0.3 ml harmaline (10 mg/kg). Spectral an

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Diefenbach, Catherine S., Bruce G. Raphael, Kenneth B. Hymes, et al. "Circulating Memory T Cells Isolated from Hodgkin Lymphoma Patients Display Evidence of Exhaustion and Chronic Activation." Blood 124, no. 21 (2014): 4400. http://dx.doi.org/10.1182/blood.v124.21.4400.4400.

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Abstract Background: In Hodgkin lymphoma (HL) the malignant Hodgkin Reed-Sternberg (HRS) cells comprise only a small fraction of the total cellular tumor population. These HRS cells orchestrate an inflammatory microenvironment of reactive cells that propagate a permissive milieu for HL growth, contributing to an ineffective local anti-tumor immune response. The peritumoral CD4 and CD8 T cells in HL patients show high expression of the receptor programmed death-1 (PD-1), involved in the functional impairment and “exhaustion” of T cells. Growing data suggests that this HL-mediated immune suppres

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Ju, Zixin, Jie Sun, and Yanping Liu. "Molecular Structures and Spectral Properties of Natural Indigo and Indirubin: Experimental and DFT Studies." Molecules 24, no. 21 (2019): 3831. http://dx.doi.org/10.3390/molecules24213831.

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This paper presents a comparative study on natural indigo and indirubin in terms of molecular structures and spectral properties by using both computational and experimental methods. The spectral properties were analyzed with Fourier transform infrared (FTIR), Raman, UV-Visible, and fluorescence techniques. The density functional theory (DFT) method with B3LYP using 6-311G(d,p) basis set was utilized to obtain their optimized geometric structures and calculate the molecular electrostatic potential, frontier molecular orbitals, FTIR, and Raman spectra. The single-excitation configuration intera

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Araten, David J., Mignon L. Loh, Meenakshi Devidas, et al. "Leukemic Blasts With The PNH Phenotype: Correlation With Cytogenetics In ALL." Blood 122, no. 21 (2013): 2628. http://dx.doi.org/10.1182/blood.v122.21.2628.2628.

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Abstract It has been proposed that hypermutability is essential for the generation of malignancies that require more than a few oncogenic mutations and may also promote the emergence of drug-resistant clones by contributing to intratumoral diversity. However, most genes are not suitable as a reporter for quantitating the frequency of spontaneous somatic inactivating mutations. A notable exception is the PIG-A gene, which encodes an enzyme catalyzing an initial step in the biosynthesis of glycosylphosphatidylinositol (GPI), which links certain membrane proteins to the cell surface. Of note, the

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Araten, David J., Leah Zamechek, and Gregory Halverson. "The Frequency of Red Cells with a Spontaneously Appearing XK-Null (McLeod-like) Phenotype Is Normal In Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)." Blood 116, no. 21 (2010): 816. http://dx.doi.org/10.1182/blood.v116.21.816.816.

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Abstract Abstract 816 Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by a large population of blood cells with an acquired somatic mutation in the X-linked PIG-A gene. This results in an inability to synthesize glycosylphosphatidylinositol (GPI) and an inability to express on the cell surface any of the proteins that require this structure. Although there are case reports of progression to leukemia or high grade myelodysplasia, in large series of patients, this occurs only rarely. It is therefore hypothesized that in PNH, the large GPI (-) population results from selection in favor

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Berto, Caroline, and Thaís Dalzochio. "Nephrotoxicity and fungal resistance associated with Amphotericin B." Saúde e meio ambiente: revista interdisciplinar 10 (February 11, 2021): 45–62. http://dx.doi.org/10.24302/sma.v10.3136.

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Introduction: Amphotericin B (AB) is the drug of choice for the treatment of several systemic fungal infections. Despite of its effectiveness and minimum relation to the resistance, AB is toxic to animal cells, in particular to the kidney cells. Objective: To address the aspects of resistance, nephrotoxicity and biomarkers available for the early detection of kidney disease caused by AB. Method: The bibliographic search was performed in online databases. Papers published between 2008-2019, were selected for further analysis and inclusion in the present review. Results: The search resulted in 4

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Stroh, Mark, Rachel Li, Hong Lu, et al. "Preliminary clinical pharmacokinetics and dose-response to support a phase II dose selection for CX-2009: A masked probody drug conjugate to CD166." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3599. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3599.

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3599 Background: PROBODY therapeutics are antibody prodrugs with cleavable peptide masks designed to reduce off-tumor, on-target toxicities. The mask blocks binding in the periphery and is removed by tumor-associated proteases resulting in intratumoral binding. CX-2009 is a PROBODY drug conjugate directed against CD166/ALCAM, which is a target overexpressed in carcinomas but not suitable for traditional ADC targeting because it is expressed in normal epithelium. CX-2009 is conjugated to DM4, a potent microtubule inhibitor. Here we report preliminary clinical pharmacokinetic (PK) and explorator

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Kerkman, Priscilla F., Emeline Fabre, Ellen I. H. van der Voort, et al. "Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis." Annals of the Rheumatic Diseases 75, no. 6 (2015): 1170–76. http://dx.doi.org/10.1136/annrheumdis-2014-207182.

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ObjectivesImmunity to citrullinated antigens is a hallmark of rheumatoid arthritis (RA). We set out to elucidate its biology by identifying and characterising citrullinated antigen-specific B cells in peripheral blood of patients with RA.MethodsDifferentially labelled streptavidin and extravidin tetramers were conjugated to biotinylated CCP2 or control antigens and used in flow cytometry to identify citrullinated antigen-specific B cells in peripheral blood. Tetramer-positive and tetramer-negative B cells were isolated by fluorescence activated cell sorting (FACS) followed by in vitro culture

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Kao, Grace, Kristen Stevenson, Elliot Kim, Elena Spanjaard, Haesook T. Kim, and Jerome Ritz. "Autologous Peripheral Blood Stem Cell Products from Patients with Hematologic Malignancies Have Increased Frequency of Regulatory T Cells (CD4+FoxP3+ Treg)." Blood 112, no. 11 (2008): 2310. http://dx.doi.org/10.1182/blood.v112.11.2310.2310.

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Abstract Increased numbers of regulatory T cells (Treg) with immune suppressive function have been observed in patients with hematological malignancies. Many of these patients will undergo stem cell mobilization with high dose cyclophosphamide and G-CSF to prepare for autologous stem cell transplantation. Although infusion of low dose cyclophosphamide (Cy) seems to reduce the number of circulating Tregs, mobilization with high dose Cy and G-CSF was shown to increase the frequency of immunosuppresive Treg in stem cell autografts of myeloma patients. Treg populations have been defined by differe

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Futyma, Konrad, Łukasz Nowakowski, Alicja Ziętek-Strobl, Aleksandra Kamińska, Nadia Taoussi, and Tomasz Rechberger. "Urine Proteomic Study in OAB Patients—Preliminary Report." Journal of Clinical Medicine 9, no. 5 (2020): 1389. http://dx.doi.org/10.3390/jcm9051389.

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Overactive bladder (OAB) is defined by International Urogynecological Association (IUGA)/ International Continence Society (ICS) as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection (UTI) or other obvious pathology. The pathophysiology of OAB is not well understood, however a number of different proteins and cytokines including vascular cell adhesion molecule-1 (VCAM-1) were found to be important in regulating structural integrity of the bladder wall. Proteome analysis may thus provide signifi

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Khan, Mohammad, Erin Cockrell, Ricardo Espinola, John R. Bartholomew, and Keith R. McCrae. "Elevated Levels of Tissue Factor Bearing Microparticles in Patients with Antiphospholipid Antibodies: Analysis of Fresh, Unfrozen Samples." Blood 114, no. 22 (2009): 148. http://dx.doi.org/10.1182/blood.v114.22.148.148.

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Abstract Abstract 148 Introduction: The antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis, and/or recurrent fetal loss in the presence of circulating antiphospholipid antibodies (APL). The pathogenesis of this disorder may involve, in part, the activation of vascular endothelial cells, platelets, and monocytes. Upon activation, these cells shed components of their plasma membranes as microparticles (MP), and procoagulant MPs are associated with an increased risk for thromboemboli. The goal of these studies was to characterize, for the first time, the frequency b

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Wood, Phillip K., Kenneth J. Sher, and Alexander Von Eye. "Conjugate and Other Distributional Methods in Configural Frequency Analysis." Biometrical Journal 36, no. 4 (1994): 387–410. http://dx.doi.org/10.1002/bimj.4710360402.

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Yegorov, Oleg, Changlin Yang, Anjelika Dechkovskaia, Maryam Rahman, Ashley Ghiaseddin, and Duane Mitchell. "CTIM-29. CRUCIAL APPLICATION OF SINGLE CELL GENE EXPRESSION FOR MONITORING CHANGES IN GLIOBLASTOMA PATIENTS WITH SUSTAINED RADIOGRAPHIC RESPONSE TO CMV pp65-LAMP RNA-PULSED DENDRITIC CELL-BASED VACCINES." Neuro-Oncology 22, Supplement_2 (2020): ii39. http://dx.doi.org/10.1093/neuonc/noaa215.163.

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Abstract BACKGROUND The application of single cell sequencing as a novel immune monitoring platform can be used to identify the molecular mechanisms of immune response to dendritic cell- based vaccines, trace the cell types and states involved, and uncover novel biomarkers for immunotherapy. We applied single-cell RNA Seq analysis of longitudinal peripheral blood mononuclear cells (PBMCs) in patients with newly-diagnosed GBM enrolled on the ATTAC II clinical trial (FDA IND BB-16530; Clinicaltrials.gov # NCT02465268) who experienced a sustained radiographic response to autologous CMV pp65-LAMP

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Shamis, Yury, Alex Taube, Natasa Mitik-Dineva, Rodney Croft, Russell J. Crawford, and Elena P. Ivanova. "Specific Electromagnetic Effects of Microwave Radiation on Escherichia coli." Applied and Environmental Microbiology 77, no. 9 (2011): 3017–22. http://dx.doi.org/10.1128/aem.01899-10.

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ABSTRACTThe present study investigated the effects of microwave (MW) radiation applied under a sublethal temperature onEscherichia coli. The experiments were conducted at a frequency of 18 GHz and at a temperature below 40°C to avoid the thermal degradation of bacterial cells during exposure. The absorbed power was calculated to be 1,500 kW/m3, and the electric field was determined to be 300 V/m. Both values were theoretically confirmed using CST Microwave Studio 3D Electromagnetic Simulation Software. As a negative control,E. colicells were also thermally heated to temperatures up to 40°C usi

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Norcia, Angela M., Elisa Y. Kimura, Akemi K. Chiba, Elyse Moritz, Mihoko Yamamoto, and Jose Orlando Bordin. "HNA−1a, −1b, −2a, −3a and −4a Frequencies in Brazilian Persons." Blood 108, no. 11 (2006): 3837. http://dx.doi.org/10.1182/blood.v108.11.3837.3837.

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Abstract Granulocyte reactive antibodies have been found to cause clinical disorders such as transfusion related acute lung injury (TRALI), febrile transfusion reactions, alloimmune neonatal neutropenia, immune neutropenia after bone marrow transplantation, refractoriness to granulocyte transfusion, drug-induced neutropenia and autoimmune neutropenia. Using the granulocyte immunofluorescence test (GIFT) by microscopic and flow cytometric analysis, the frequencies of the neutrophil antigens HNA−1a, −1b, −2a, −3a and −4a were determined among 100 random Brazilian blood donors from the Blood Cent

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Longo, Diane, Brent Louie, Kavita Mathi, et al. "Single Cell Network Profiling (SCNP) Reveals Race-Associated Differences in B Cell Receptor Signaling Pathway Activation." Blood 118, no. 21 (2011): 1125. http://dx.doi.org/10.1182/blood.v118.21.1125.1125.

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Abstract Abstract 1125 Race-related differences have been documented in the incidence of autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis, in the clinical response to immunotherapies [such as IFNα (in HCV infections) and belimumab (in systemic lupus erythematosus)] and to hematopoietic stem cell transplantation. However, the basis for such race-associated differences remains poorly understood. Single Cell Network Profiling (SCNP) is a multiparametric flow cytometry based approach that simultaneously measures intracellular signaling activity in multiple cell subpo

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Schmitt, Anita, Junxia Yao, Hermann Einsele, et al. "Streptamer Technology for the Assessment of CMVpp65 Specific CD8+ T Cell Frequencies and for the Adoptive T Cell Transfer to Post-Transplant Patients." Blood 110, no. 11 (2007): 1964. http://dx.doi.org/10.1182/blood.v110.11.1964.1964.

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Abstract Cytomegalovirus (CMV) reactivation constitutes a serious complication after allogeneic peripheral blood stem cell transplantation (PBSCT). The frequency of CMVpp65 specific CD8+ T cells is pivotal for the clearance of CMV. CMVpp65 specific CD8+ T cell frequencies can be measured using tetra-, penta- and streptamer technologies, streptamers can also be applied therapeutically. In donors, these frequencies might allow us to define the best available donor in addition to the mere serostatus. In the present study we investigated the specificity and sensitivity of all three methods and com

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Mirro, J., TF Zipf, CH Pui, et al. "Acute mixed lineage leukemia: clinicopathologic correlations and prognostic significance." Blood 66, no. 5 (1985): 1115–23. http://dx.doi.org/10.1182/blood.v66.5.1115.1115.

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Abstract The frequency and clinical significance of acute leukemia displaying both lymphoid and myeloid characteristics was determined in 123 consecutive children using a panel of lineage-associated markers. The leukemic blasts from 18 of 95 children (19%) with the diagnosis of acute lymphoblastic leukemia (ALL) by standard diagnostic criteria expressed myeloid-associated cell surface antigens. Despite immunological evidence of lymphoid differentiation (17 CALLA + and one T cell-associated antigen +) and findings of immunoglobulin gene rearrangement, blasts from these patients reacted with one

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Mirro, J., TF Zipf, CH Pui, et al. "Acute mixed lineage leukemia: clinicopathologic correlations and prognostic significance." Blood 66, no. 5 (1985): 1115–23. http://dx.doi.org/10.1182/blood.v66.5.1115.bloodjournal6651115.

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The frequency and clinical significance of acute leukemia displaying both lymphoid and myeloid characteristics was determined in 123 consecutive children using a panel of lineage-associated markers. The leukemic blasts from 18 of 95 children (19%) with the diagnosis of acute lymphoblastic leukemia (ALL) by standard diagnostic criteria expressed myeloid-associated cell surface antigens. Despite immunological evidence of lymphoid differentiation (17 CALLA + and one T cell-associated antigen +) and findings of immunoglobulin gene rearrangement, blasts from these patients reacted with one to five

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36

Möllenkvist, Andrea, Therése Nordström, Christer Halldén, Jens Jørgen Christensen, Arne Forsgren, and Kristian Riesbeck. "The Moraxella catarrhalis Immunoglobulin D-Binding Protein MID Has Conserved Sequences and Is Regulated by a Mechanism Corresponding to Phase Variation." Journal of Bacteriology 185, no. 7 (2003): 2285–95. http://dx.doi.org/10.1128/jb.185.7.2285-2295.2003.

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ABSTRACT The prevalence of the Moraxella catarrhalis immunoglobulin D (IgD)-binding outer membrane protein MID and its gene was determined in 91 clinical isolates and in 7 culture collection strains. Eighty-four percent of the clinical Moraxella strains expressed MID-dependent IgD binding. The mid gene was detected in all strains as revealed by homology of the signal peptide sequence and a conserved area in the 3′ end of the gene. When MID proteins from five different strains were compared, an identity of 65.3 to 85.0% and a similarity of 71.2 to 89.1% were detected. Gene analyses showed sever

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Vennapusa, Amaranatha Reddy, Felipe Faleco, Bruno Vieira, et al. "Prevalence and Mechanism of Atrazine Resistance in Waterhemp (Amaranthus tuberculatus) from Nebraska." Weed Science 66, no. 5 (2018): 595–602. http://dx.doi.org/10.1017/wsc.2018.38.

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AbstractResistance to atrazine (a photosystem II [PSII] inhibitor) is prevalent in waterhemp [Amaranthus tuberculatus(Moq.) J. D. Sauer] across the U.S. Midwest. Previous research suggests that target-site mutation or rapid metabolism of atrazine mediated by glutathioneS-transferase (GST) conjugation confers resistance inA. tuberculatusfrom Illinois. The distribution and mechanism of resistance to atrazine inA. tuberculatuspopulations from Nebraska (NE) are unknown. In this research we (1) evaluated the response and frequency of resistance in NEA. tuberculatusto soil-applied PSII (metribuzin a

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Tuffin, I. Marla, Peter de Groot, Shelly M. Deane, and Douglas E. Rawlings. "An unusual Tn21-like transposon containing an ars operon is present in highly arsenic-resistant strains of the biomining bacterium Acidithiobacillus caldus." Microbiology 151, no. 9 (2005): 3027–39. http://dx.doi.org/10.1099/mic.0.28131-0.

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A transposon, TnAtcArs, that carries a set of arsenic-resistance genes was isolated from a strain of the moderately thermophilic, sulfur-oxidizing, biomining bacterium Acidithiobacillus caldus. This strain originated from a commercial plant used for the bio-oxidation of gold-bearing arsenopyrite concentrates. Continuous selection for arsenic resistance over many years had made the bacterium resistant to high concentrations of arsenic. Sequence analysis indicated that TnAtcArs is 12 444 bp in length and has 40 bp terminal inverted repeat sequences and divergently transcribed resolvase and trans

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Wang, Yuhuan, Yukako Ono, Yasuo Ikeda, et al. "Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf." Blood 118, no. 21 (2011): 908. http://dx.doi.org/10.1182/blood.v118.21.908.908.

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Abstract Abstract 908 The determinant factors leading from stem cells to megakaryocytes (MK) and the subsequent release of platelets have yet to be identified. Here we report that a combination of transcription factors p45NF-E2, MafG, and MafK converts mouse fibroblast cell line 3T3 and adult human dermal fibroblasts into MKs. We first performed screening for MK-inducing factors using the preadipocyte cell line 3T3-L1 known to be able to differentiate into MKs in a previously defined MK lineage induction media containing thrombopoietin (Zauli G et al, Blood 1997). Gene expression levels of can

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Hauschild, J., A. L. Queisser, J. W. Carnwath та ін. "329 GENETIC TARGETING OF THE PORCINE α1,3-GALACTOSYLTRANSFERASE GENE IN FETAL FIBROBLAST CELLS USING ZINC FINGER NUCLEASES". Reproduction, Fertility and Development 23, № 1 (2011): 260. http://dx.doi.org/10.1071/rdv23n1ab329.

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Hyperacute rejection after porcine-to-human xenotransplantation is caused by binding of preformed human antibodies against Gal-epitopes on the surface of porcine cells. Organs from Gal-negative pigs have shown prolonged survival after transplantation into baboons. Knocking out a gene by conventional gene targeting frequency is extremely inefficient (homologous recombination = 0.0001 to 0.001%; Denning et al. 2001). Recent publications in rats (Geurts et al. 2009) show that the gene knockout via zinc finger nuclease (ZFN)-driven nonhomologous end joining (NHEJ) can be enhanced 10 000-fold over

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Green, Gloria A., Beau R. Braden, Obianuju Mba, Stacy A. Chivira, Laleh Ramezani, and Cage Saul Johnson. "Hydroxyurea Induced Expression of gamma Globin and Erythrocyte Membrane Proteins in Cultured Erythroid Progenitor Cells." Blood 108, no. 11 (2006): 3797. http://dx.doi.org/10.1182/blood.v108.11.3797.3797.

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Abstract BACKGROUND: Hydroxyurea (HU) an S-phase specific cytotoxic agent has been used for the treatment of patients with sickle cell anemia and beta-thalassemia. The clinical efficacy of HU is due primarily to increases in fetal hemoglobin (HbF) levels. HU increases the %HbF and the %F cells. The HU reactive mechanism(s) in erythroid cells, however, have not been clearly defined. Patients receiving HU therapy develop subpopulations of macrocytic erythrocytes. Our previous studies demonstrate that sickle cell patients treated with low dose HU develop subpopulations of RBCs that express greate

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Green, Gloria A., Beau R. Braden, Obianuju Mba, Stacy A. Chivira, Laleh Ramezani, and Cage S. Johnson. "Hydroxyurea Induced Expression of Erythrocyte Anion Exchange Protein [AE1] and Gamma Globin in Cultured Erythroid Progenitor Cells." Blood 106, no. 11 (2005): 3536. http://dx.doi.org/10.1182/blood.v106.11.3536.3536.

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Abstract Background: Hydroxyurea (HU) an S-phase specific cytotoxic agent has been used for the treatment of patients with sickle cell anemia and beta-thalassemia. The clinical efficacy of HU is due primarily to increases in fetal hemoglobin (HbF) levels. HU increases the %HbF and the %F cells. The HU reactive mechanism(s) in erythroid cells, however, have not been clearly defined. Patients receiving HU therapy develop subpopulations of macrocytic erythrocytes. Our previous studies demonstrate that sickle cell patients treated with low dose HU develop subpopulations of RBCs that express greate

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PAI, P. FRANK. "CIRCULAR INSTANTANEOUS FREQUENCY." Advances in Adaptive Data Analysis 02, no. 01 (2010): 39–64. http://dx.doi.org/10.1142/s1793536910000380.

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This work defines the unique instantaneous frequency (IF) of an arbitrary time signal to be the circular instantaneous frequency (cIF) of the curvature radius of the signal's trajectory on the phase plane, where the signal's conjugate part is obtained from Hilbert transform (HT). Because a general signal of a dynamical system of multiple degrees of freedom contains multiple modal vibrations, its cIF varies dramatically and is not useful for system identification and other applications. If the signal is decomposed into modal vibration components without moving average, each component has no loc

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Petersen, G. M., P. Niemz, S. Cesca, V. Mouslopoulou, and G. M. Bocchini. "Clusty, the waveform-based network similarity clustering toolbox: concept and application to image complex faulting offshore Zakynthos (Greece)." Geophysical Journal International 224, no. 3 (2020): 2044–59. http://dx.doi.org/10.1093/gji/ggaa568.

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SUMMARY Clusty is a new open source toolbox dedicated to earthquake clustering based on waveforms recorded across a network of seismic stations. Its main application is the study of active faults and the detection and characterization of faults and fault networks. By using a density-based clustering approach, earthquakes pertaining to a common fault can be recognized even over long fault segments, and the first-order geometry and extent of active faults can be inferred. Clusty implements multiple techniques to compute a waveform based network similarity from maximum cross-correlation coefficie

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Kalfa, Theodosia A., Suvarnamala Pushkaran, Jose A. Cancelas, et al. "Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation." Blood 108, no. 11 (2006): 467. http://dx.doi.org/10.1182/blood.v108.11.467.467.

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Abstract The small Rho GTPases Rac1 and Rac2 have overlapping as well as distinct roles in actin organization, cell survival, and proliferation in various hematopoietic cell lineages. However their role in erythropoiesis has not yet been fully elucidated. Using conditional gene-targeted mice we demonstrated that deficiency of Rac1 and Rac2 GTPases causes a significant phenotype in erythroid lineage. The mice develop anemia that is both hemolytic (abnormal structure of the erythrocyte cytoskeleton and decreased deformability; Kalfa et al. Blood 2006) and dyserythropoietic in nature. Cre-recombi

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Araten, David J., Ken Csehak, Daniel Anscher, and Leah Zamechek. "Quantitative Analysis of the Effects of MYC Overexpression on the Mutation Rate in Human Cells Using the PIG-A Gene." Blood 118, no. 21 (2011): 4406. http://dx.doi.org/10.1182/blood.v118.21.4406.4406.

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Abstract Abstract 4406 It has been hypothesized that the early acquisition of genomic instability is essential to account for the high number of mutations commonly identified in human cancers. Previous reports have demonstrated that MYC overexpression results in gene amplification. Given the importance of MYC in Burkitt’s lymphoma, we investigated the effects of MYC on spontaneous inactivating somatic mutations, using an assay that we have developed, based on the PIG-A gene. PIG-A is X-linked, thus a single mutation can disrupt its function. PIG-A encodes an enzyme required for the biosynthesi

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Yegorov, Oleg, Changlin Yang, Maryam Rahman, et al. "ATIM-34. SINGLE-CELL RNA SEQUENCING REVEALS DYNAMIC IMMUNE RESPONSE CHANGES IN GLIOBLASTOMA PATIENT WITH DURABLE COMPLETE RESPONSE TO CMV PP65-LAMP RNA-PULSED DENDRITIC VACCINES." Neuro-Oncology 21, Supplement_6 (2019): vi9. http://dx.doi.org/10.1093/neuonc/noz175.033.

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Abstract BACKGROUND The application of single cell sequencing as a novel immune monitoring platform can enhance the ability to interrogate at unprecedented depth the single-cell level dynamic phenotypic and functional attributes of immune cells in patients undergoing cancer immunotherapy treatment. We applied single-cell sequencing analysis of PBMCs in a patient with newly-diagnosed GBM enrolled on the ATTAC II clinical trial (FDA IND BB-16530) who experienced a sustained complete radiographic response to autologous CMV pp65-LAMP RNA-pulsed DC vaccines plus GM-CSF and tetanus-diphtheria booste

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Nanda, Aditya, Puneet Singla, and M. Amin Karami. "Conjugate unscented transformation–based uncertainty analysis of energy harvesters." Journal of Intelligent Material Systems and Structures 29, no. 18 (2018): 3614–33. http://dx.doi.org/10.1177/1045389x18798945.

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This article presents a probabilistic approach to investigate the effect of parametric uncertainties on the mean power, tip deflection, and tip velocity of linear and nonlinear energy harvesting systems. Recently developed conjugate unscented transformation algorithm is used to compute the statistical moments of the output variables with multidimensional Gaussian uncertainty in parameters. The principle of maximum entropy is used to construct the probability density function of output variables from the knowledge of obtained statistical moments. The probability density functions for mean power

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Green, Kirk, and Bernd Krauskopf. "Bifurcation Analysis of Frequency Locking in a Semiconductor Laser with Phase-Conjugate Feedback." International Journal of Bifurcation and Chaos 13, no. 09 (2003): 2589–601. http://dx.doi.org/10.1142/s0218127403008107.

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We present a detailed study of the external-cavity modes (ECMs) of a semiconductor laser with phase-conjugate feedback. Mathematically, lasers with feedback are modeled by delay differential equations (DDEs) with an infinite-dimensional phase space. We employ new numerical bifurcation tools for DDEs to continue steady states and periodic orbits, irrespective of their stability. In this way, we show that the periodic orbits corresponding to the ECMs are connected to the steady state solution associated with the locking range of the laser. We also identify symmetric and nonsymmetric homoclinic o

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Chen, Qian, Kai Gu, and Li Li Zhai. "Analysis of Adaptive Beamforming Based on Convex Optimization." Applied Mechanics and Materials 651-653 (September 2014): 2262–68. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.2262.

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Most of the signal in the communication system have the cyclostationary property. Many algorithms based on the cyclostationary of the signal in the array signal processing have been exploited. They can well work without knowing the steering vector of interested signal, thus they all belong to the blind algorithms. When there is cycle frequency error, a mathematical analysis of gradient decent-based algorithm is provided in this paper. It pointed out that due to the zero point effect of the sinc function, the above approach have periodic deterioration as the number of snapshot increasing. Hence

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