Log in

Relevant bibliographies by topics / Conserved Regulatory Sequences / Journal articles

To see the other types of publications on this topic, follow the link: Conserved Regulatory Sequences.

Journal articles on the topic 'Conserved Regulatory Sequences'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Conserved Regulatory Sequences.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Skowronska-Krawczyk, D., F. Chiodini, M. Ebeling, et al. "Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis." Development 136, no. 22 (2009): 3767–77. http://dx.doi.org/10.1242/dev.033449.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Ciren, Danielle, Sophia Zebell, and Zachary B. Lippman. "Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator." PLOS Genetics 20, no. 3 (2024): e1011174. http://dx.doi.org/10.1371/journal.pgen.1011174.

Full text

Abstract:

A striking paradox is that genes with conserved protein sequence, function and expression pattern over deep time often exhibit extremely divergent cis-regulatory sequences. It remains unclear how such drastic cis-regulatory evolution across species allows preservation of gene function, and to what extent these differences influence how cis-regulatory variation arising within species impacts phenotypic change. Here, we investigated these questions using a plant stem cell regulator conserved in expression pattern and function over ~125 million years. Using in-vivo genome editing in two distantly

APA, Harvard, Vancouver, ISO, and other styles

3

Britton, Candace S., Trevor R. Sorrells, and Alexander D. Johnson. "Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit." Science 367, no. 6473 (2020): 96–100. http://dx.doi.org/10.1126/science.aax5217.

Full text

Abstract:

Changes in both the coding sequence of transcriptional regulators and in the cis-regulatory sequences recognized by these regulators have been implicated in the evolution of transcriptional circuits. However, little is known about how they evolved in concert. We describe an evolutionary pathway in fungi where a new transcriptional circuit (a-specific gene repression by the homeodomain protein Matα2) evolved by coding changes in this ancient regulator, followed millions of years later by cis-regulatory sequence changes in the genes of its future regulon. By analyzing a group of species that has

APA, Harvard, Vancouver, ISO, and other styles

4

Hardison, R. "Conserved noncoding sequences are reliable guides to regulatory elements." Trends in Genetics 16, no. 9 (2000): 369–72. http://dx.doi.org/10.1016/s0168-9525(00)02081-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Adams, Mark D. "Conserved sequences and the evolution of gene regulatory signals." Current Opinion in Genetics & Development 15, no. 6 (2005): 628–33. http://dx.doi.org/10.1016/j.gde.2005.09.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Cruz, Maria Araceli Diaz, Dan Lund, Ferenc Szekeres, Sandra Karlsson, Maria Faresjö, and Dennis Larsson. "Cis-regulatory elements in conserved non-coding sequences of nuclear receptor genes indicate for crosstalk between endocrine systems." Open Medicine 16, no. 1 (2021): 640–50. http://dx.doi.org/10.1515/med-2021-0264.

Full text

Abstract:

Abstract Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but not to an extent at a genetic level. This study aimed to investigate crosstalk between steroid NRs in conserved intron and exon sequences, with a focus on steroid NRs involved in prostate cancer etiology. For this purpose, we evaluated conserved intron and exon sequences among all 49 members of the NR Superfamily (NRS) and their relevan

APA, Harvard, Vancouver, ISO, and other styles

7

Yocca, Alan E., Zefu Lu, Robert J. Schmitz, Michael Freeling, and Patrick P. Edger. "Evolution of Conserved Noncoding Sequences in Arabidopsis thaliana." Molecular Biology and Evolution 38, no. 7 (2021): 2692–703. http://dx.doi.org/10.1093/molbev/msab042.

Full text

Abstract:

Abstract Recent pangenome studies have revealed a large fraction of the gene content within a species exhibits presence–absence variation (PAV). However, coding regions alone provide an incomplete assessment of functional genomic sequence variation at the species level. Little to no attention has been paid to noncoding regulatory regions in pangenome studies, though these sequences directly modulate gene expression and phenotype. To uncover regulatory genetic variation, we generated chromosome-scale genome assemblies for thirty Arabidopsis thaliana accessions from multiple distinct habitats an

APA, Harvard, Vancouver, ISO, and other styles

8

Taher, L., D. M. McGaughey, S. Maragh, et al. "Genome-wide identification of conserved regulatory function in diverged sequences." Genome Research 21, no. 7 (2011): 1139–49. http://dx.doi.org/10.1101/gr.119016.110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

LE, SHU-YUN, JACOB V. MAIZEL, and KAIZHONG ZHANG. "FINDING CONSERVED WELL-ORDERED RNA STRUCTURES IN GENOMIC SEQUENCES." International Journal of Computational Intelligence and Applications 04, no. 04 (2004): 417–30. http://dx.doi.org/10.1142/s1469026804001409.

Full text

Abstract:

Recent advances in RNA studies show that the well-ordered, structured RNAs perform a broad functions in various biological mechanisms. Included among these functions are regulations of gene expression at multiple levels by diversified ribozymes and various RNA regulatory elements. The discovered microRNAs (miRNAs) with a distinct stem-loops are a new class of RNA regulatory elements. The prediction of those well-ordered folding sequences (WFS) associated with the RNA regulatory elements in genomic sequences is very helpful for our understandings of RNA-based gene regulations. We present here a

APA, Harvard, Vancouver, ISO, and other styles

10

Vikkula, M., M. Metsäranta, A. C. Syvänen, L. Ala-Kokko, E. Vuorio, and L. Peltonen. "Structural analysis of the regulatory elements of the type-II procollagen gene. Conservation of promoter and first intron sequences between human and mouse." Biochemical Journal 285, no. 1 (1992): 287–94. http://dx.doi.org/10.1042/bj2850287.

Full text

Abstract:

Transcription of the type-II procollagen gene (COL2A1) is very specifically restricted to a limited number of tissues, particularly cartilages. In order to identify transcription-control motifs we have sequenced the promoter region and the first intron of the human and mouse COL2A1 genes. With the assumption that these motifs should be well conserved during evolution, we have searched for potential elements important for the tissue-specific transcription of the COL2A1 gene by aligning the two sequences with each other and with the available rat type-II procollagen sequence for the promoter. Wi

APA, Harvard, Vancouver, ISO, and other styles

11

Mao, Linyong, Chris Mackenzie, Jung H. Roh, Jesus M. Eraso, Samuel Kaplan, and Haluk Resat. "Combining microarray and genomic data to predict DNA binding motifs." Microbiology 151, no. 10 (2005): 3197–213. http://dx.doi.org/10.1099/mic.0.28167-0.

Full text

Abstract:

The ability to detect regulatory elements within genome sequences is important in understanding how gene expression is controlled in biological systems. In this work, microarray data analysis is combined with genome sequence analysis to predict DNA sequences in the photosynthetic bacterium Rhodobacter sphaeroides that bind the regulators PrrA, PpsR and FnrL. These predictions were made by using hierarchical clustering to detect genes that share similar expression patterns. The DNA sequences upstream of these genes were then searched for possible transcription factor recognition motifs that may

APA, Harvard, Vancouver, ISO, and other styles

12

Santagati, Fabio, Kuniya Abe, Volker Schmidt, et al. "Identification of Cis-regulatory Elements in the Mouse Pax9/Nkx2-9 Genomic Region: Implication for Evolutionary Conserved Synteny." Genetics 165, no. 1 (2003): 235–42. http://dx.doi.org/10.1093/genetics/165.1.235.

Full text

Abstract:

Abstract We previously reported close physical linkage between Pax9 and Nkx2-9 in the human, mouse, and pufferfish (Fugu rubripes) genomes. In this study, we analyzed cis-regulatory elements of the two genes by comparative sequencing in the three species and by transgenesis in the mouse. We identified two regions including conserved noncoding sequences that possessed specific enhancer activities for expression of Pax9 in the medial nasal process and of Nkx2-9 in the ventral neural tube. Remarkably, the latter contained the consensus Gli-binding motif. Interestingly, the identified Pax9 cis-reg

APA, Harvard, Vancouver, ISO, and other styles

13

Fuentes-Pananá, Ezequiel M., Sankar Swaminathan, and Paul D. Ling. "Transcriptional Activation Signals Found in the Epstein-Barr Virus (EBV) Latency C Promoter Are Conserved in the Latency C Promoter Sequences from Baboon and Rhesus Monkey EBV-Like Lymphocryptoviruses (Cercopithicine Herpesviruses 12 and 15)." Journal of Virology 73, no. 1 (1999): 826–33. http://dx.doi.org/10.1128/jvi.73.1.826-833.1999.

Full text

Abstract:

ABSTRACT The Epstein-Barr virus (EBV) EBNA2 protein is a transcriptional activator that controls viral latent gene expression and is essential for EBV-driven B-cell immortalization. EBNA2 is expressed from the viral C promoter (Cp) and regulates its own expression by activating Cp through interaction with the cellular DNA binding protein CBF1. Through regulation of Cp and EBNA2 expression, EBV controls the pattern of latent protein expression and the type of latency established. To gain further insight into the important regulatory elements that modulate Cp usage, we isolated and sequenced the

APA, Harvard, Vancouver, ISO, and other styles

14

McEwen, Gayle K., Debbie K. Goode, Hugo J. Parker, Adam Woolfe, Heather Callaway, and Greg Elgar. "Early Evolution of Conserved Regulatory Sequences Associated with Development in Vertebrates." PLoS Genetics 5, no. 12 (2009): e1000762. http://dx.doi.org/10.1371/journal.pgen.1000762.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Donnard, Elisa, Pranitha Vangala, Shaked Afik, et al. "Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon." Cell systems 6, no. 3 (2018): 381–94. https://doi.org/10.5281/zenodo.13526146.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Most well-characterized enhancers are deeply conserved. In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved. To better understand conservation of enhancer activity, we used a comparative genomics approach that integrates temporal expression and epigenetic profiles in an innate immune system. We found that gene expression programs diverge among mildly induced genes, while being highly conserved for strongly induced genes. The fraction of conserved enhancers var

APA, Harvard, Vancouver, ISO, and other styles

16

Donnard, Elisa, Pranitha Vangala, Shaked Afik, et al. "Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon." Cell systems 6, no. 3 (2018): 381–94. https://doi.org/10.5281/zenodo.13526146.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Most well-characterized enhancers are deeply conserved. In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved. To better understand conservation of enhancer activity, we used a comparative genomics approach that integrates temporal expression and epigenetic profiles in an innate immune system. We found that gene expression programs diverge among mildly induced genes, while being highly conserved for strongly induced genes. The fraction of conserved enhancers var

APA, Harvard, Vancouver, ISO, and other styles

17

Donnard, Elisa, Pranitha Vangala, Shaked Afik, et al. "Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon." Cell systems 6, no. 3 (2018): 381–94. https://doi.org/10.5281/zenodo.13526146.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Most well-characterized enhancers are deeply conserved. In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved. To better understand conservation of enhancer activity, we used a comparative genomics approach that integrates temporal expression and epigenetic profiles in an innate immune system. We found that gene expression programs diverge among mildly induced genes, while being highly conserved for strongly induced genes. The fraction of conserved enhancers var

APA, Harvard, Vancouver, ISO, and other styles

18

Donnard, Elisa, Pranitha Vangala, Shaked Afik, et al. "Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon." Cell systems 6, no. 3 (2018): 381–94. https://doi.org/10.5281/zenodo.13526146.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Most well-characterized enhancers are deeply conserved. In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved. To better understand conservation of enhancer activity, we used a comparative genomics approach that integrates temporal expression and epigenetic profiles in an innate immune system. We found that gene expression programs diverge among mildly induced genes, while being highly conserved for strongly induced genes. The fraction of conserved enhancers var

APA, Harvard, Vancouver, ISO, and other styles

19

Spicher, Albert, Oivin M. Guicherit, Laurent Duret, et al. "Highly Conserved RNA Sequences That Are Sensors of Environmental Stress." Molecular and Cellular Biology 18, no. 12 (1998): 7371–82. http://dx.doi.org/10.1128/mcb.18.12.7371.

Full text

Abstract:

ABSTRACTThe putative function of highly conserved regions (HCRs) within 3′ untranslated regions (3′UTRs) as regulatory RNA sequences was efficiently and quantitatively assessed by using modular retroviral vectors. This strategy led to the identification of HCRs that alter gene expression in response to oxidative or mitogenic stress. Databases were screened for UTR sequences of >100 nucleotides that had retained 70% identity over more than 300 million years of evolution. The effects of 10 such HCRs on a standard reporter mRNA or protein were studied. To this end, we developed a modular retro

APA, Harvard, Vancouver, ISO, and other styles

20

Roberts, Samantha A., Gordon G. Churchward, and June R. Scott. "Unraveling the Regulatory Network in Streptococcus pyogenes: the Global Response Regulator CovR Represses rivR Directly." Journal of Bacteriology 189, no. 4 (2006): 1459–63. http://dx.doi.org/10.1128/jb.01026-06.

Full text

Abstract:

ABSTRACT The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.

APA, Harvard, Vancouver, ISO, and other styles

21

Todor, Horia, Hendrik Osadnik, Elizabeth A. Campbell, et al. "Rewiring the specificity of extracytoplasmic function sigma factors." Proceedings of the National Academy of Sciences 117, no. 52 (2020): 33496–506. http://dx.doi.org/10.1073/pnas.2020204117.

Full text

Abstract:

Bacterial genomes are being sequenced at an exponentially increasing rate, but our inability to decipher their transcriptional wiring limits our ability to derive new biology from these sequences. De novo determination of regulatory interactions requires accurate prediction of regulators’ DNA binding and precise determination of biologically significant binding sites. Here we address these challenges by solving the DNA-specificity code of extracytoplasmic function sigma factors (ECF σs), a major family of bacterial regulators, and determining their putative regulons. We generated an aligned co

APA, Harvard, Vancouver, ISO, and other styles

22

Laverré, Alexandre, Eric Tannier, and Anamaria Necsulea. "Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness." Genome Research 32, no. 2 (2021): 280–96. http://dx.doi.org/10.1101/gr.275901.121.

Full text

Abstract:

Gene expression is regulated through complex molecular interactions, involving cis-acting elements that can be situated far away from their target genes. Data on long-range contacts between promoters and regulatory elements are rapidly accumulating. However, it remains unclear how these regulatory relationships evolve and how they contribute to the establishment of robust gene expression profiles. Here, we address these questions by comparing genome-wide maps of promoter-centered chromatin contacts in mouse and human. We show that there is significant evolutionary conservation of cis-regulator

APA, Harvard, Vancouver, ISO, and other styles

23

FATIMA, S., KUHT CHEEMA, M. SHAFIQ, et al. "GENOME-WIDE BIOINFORMATICS ANALYSIS OF 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE (ACS), 1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE (ACO) AND ETHYLENE OVERPRODUCER 1 (ETO1) GENE FAMILY OF FRAGARIA VESCA (WOODLAND STRAWBERRY)." Bulletin of Biological and Allied Sciences Research 2023, no. 1 (2023): 38. http://dx.doi.org/10.54112/bbasr.v2023i1.38.

Full text

Abstract:

This study was made on three genes ACS, ACO, and ETO, which are involved in ethylene biosynthesis pathway in Fragaria vesa plant, to know about evolution, conserved motifs and domains, gene expressions, and phylogeny of these genes. After carefully screening using Phytozome plant gene database, NCBI gene database, Motif finder, and MegaX phylogenetic tree 10 gene sequences of ACS, 5 gene sequences of ACO and 3 gene sequences of ETO were identified. Four ETO gene sequences of Arabidopsis thaliana were also used to authenticate this research because only 3 ETO gene sequences of Fragaria vesca an

APA, Harvard, Vancouver, ISO, and other styles

24

Trouillon, Julian, Erwin Sentausa, Michel Ragno, et al. "Species-specific recruitment of transcription factors dictates toxin expression." Nucleic Acids Research 48, no. 5 (2020): 2388–400. http://dx.doi.org/10.1093/nar/gkz1232.

Full text

Abstract:

Abstract Tight and coordinate regulation of virulence determinants is essential for bacterial biology and involves dynamic shaping of transcriptional regulatory networks during evolution. The horizontally transferred two-partner secretion system ExlB–ExlA is instrumental in the virulence of different Pseudomonas species, ranging from soil- and plant-dwelling biocontrol agents to the major human pathogen Pseudomonas aeruginosa. Here, we identify a Cro/CI-like repressor, named ErfA, which together with Vfr, a CRP-like activator, controls exlBA expression in P. aeruginosa. The characterization of

APA, Harvard, Vancouver, ISO, and other styles

25

Pauls, Stefan, Debbie K. Goode, Libero Petrone, Paola Oliveri, and Greg Elgar. "Evolution of lineage-specific functions in ancient cis -regulatory modules." Open Biology 5, no. 11 (2015): 150079. http://dx.doi.org/10.1098/rsob.150079.

Full text

Abstract:

Morphological evolution is driven both by coding sequence variation and by changes in regulatory sequences. However, how cis -regulatory modules (CRMs) evolve to generate entirely novel expression domains is largely unknown. Here, we reconstruct the evolutionary history of a lens enhancer located within a CRM that not only predates the lens, a vertebrate innovation, but bilaterian animals in general. Alignments of orthologous sequences from different deuterostomes sub-divide the CRM into a deeply conserved core and a more divergent flanking region. We demonstrate that all deuterostome flanking

APA, Harvard, Vancouver, ISO, and other styles

26

Vaughn, J. N., S. R. Ellingson, F. Mignone, and A. von Arnim. "Known and novel post-transcriptional regulatory sequences are conserved across plant families." RNA 18, no. 3 (2012): 368–84. http://dx.doi.org/10.1261/rna.031179.111.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Baxter, Laura, Aleksey Jironkin, Richard Hickman, et al. "Conserved Noncoding Sequences Highlight Shared Components of Regulatory Networks in Dicotyledonous Plants." Plant Cell 24, no. 10 (2012): 3949–65. http://dx.doi.org/10.1105/tpc.112.103010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Kawamura, Shoji, Kumiko Takeshita, Taro Tsujimura, Satoshi Kasagi, and Yoshifumi Matsumoto. "Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 141, no. 4 (2005): 391–99. http://dx.doi.org/10.1016/j.cbpc.2005.03.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Alexandre, Cristina M., James R. Urton, Ken Jean-Baptiste, et al. "Complex Relationships between Chromatin Accessibility, Sequence Divergence, and Gene Expression in Arabidopsis thaliana." Molecular Biology and Evolution 35, no. 4 (2017): 837–54. http://dx.doi.org/10.1093/molbev/msx326.

Full text

Abstract:

AbstractVariation in regulatory DNA is thought to drive phenotypic variation, evolution, and disease. Prior studies of regulatory DNA and transcription factors across animal species highlighted a fundamental conundrum: Transcription factor binding domains and cognate binding sites are conserved, while regulatory DNA sequences are not. It remains unclear how conserved transcription factors and dynamic regulatory sites produce conserved expression patterns across species. Here, we explore regulatory DNA variation and its functional consequences within Arabidopsis thaliana, using chromatin access

APA, Harvard, Vancouver, ISO, and other styles

30

Javier Tovar, Francisco, Luiz Antônio Ferreira da Silva, Renato Santos Rodarte, and Orilio Leoncini. "Characterization of ribosomal DNA (rDNA) in Drosophila arizonae." Genetics and Molecular Biology 23, no. 2 (2000): 231–33. http://dx.doi.org/10.1590/s1415-47572000000200015.

Full text

Abstract:

Ribosomal DNA (rDNA) is a multigenic family composed of one or more clusters of repeating units (RU). Each unit consists of highly conserved sequences codifying 18S, 5.8S and 28S rRNA genes intercalated with poorly conserved regulatory sequences between species. In this work, we analyzed the rDNA of Drosophila arizonae, a member of the mulleri complex (Repleta group). Using genomic restriction patterns, cloning and mapping of some representative rDNA fragments, we were able to construct a representative restriction map. RU in this species are 13.5-14 kb long, restriction sites are completely c

APA, Harvard, Vancouver, ISO, and other styles

31

Gallegos, M. T., R. Schleif, A. Bairoch, K. Hofmann, and J. L. Ramos. "Arac/XylS family of transcriptional regulators." Microbiology and Molecular Biology Reviews 61, no. 4 (1997): 393–410. http://dx.doi.org/10.1128/mmbr.61.4.393-410.1997.

Full text

Abstract:

The ArC/XylS family of prokaryotic positive transcriptional regulators includes more than 100 proteins and polypeptides derived from open reading frames translated from DNA sequences. Members of this family are widely distributed and have been found in the gamma subgroup of the proteobacteria, low- and high-G + C-content gram-positive bacteria, and cyanobacteria. These proteins are defined by a profile that can be accessed from PROSITE PS01124. Members of the family are about 300 amino acids long and have three main regulatory functions in common: carbon metabolism, stress response, and pathog

APA, Harvard, Vancouver, ISO, and other styles

32

Song, D. L., G. Chalepakis, P. Gruss, and A. L. Joyner. "Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene." Development 122, no. 2 (1996): 627–35. http://dx.doi.org/10.1242/dev.122.2.627.

Full text

Abstract:

The temporally and spatially restricted expression of the mouse Engrailed (En) genes is essential for development of the midbrain and cerebellum. The regulation of En-2 expression was studied using in vitro protein-DNA binding assays and in vivo expression analysis in transgenic mice to gain insight into the genetic events that lead to regionalization of the developing brain. A minimum En-2 1.0 kb enhancer fragment was defined and found to contain multiple positive and negative regulatory elements that function in concert to establish the early embryonic mid-hindbrain expression. Furthermore,

APA, Harvard, Vancouver, ISO, and other styles

33

Dovat, Sinisa, Kirk A. Gilbert, Lidija Petrovic-Dovat, and D. Eugene Rannels. "Targeted identification of zinc finger genes expressed in rat lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 275, no. 1 (1998): L30—L37. http://dx.doi.org/10.1152/ajplung.1998.275.1.l30.

Full text

Abstract:

Control of alveolar cell growth and differentiation after pneumonectomy likely involves changes in expression of regulatory genes, including those encoding zinc finger (ZF) proteins. To explore this premise, total RNA from the lungs of control and pneumonectomized rats was reverse transcribed; PCRs were performed with degenerate primers corresponding to amino acid sequences HTGEKP and CPECGK(N), which are evolutionarily conserved among ZF genes. Reaction products corresponding to three and four ZF units were isolated and cloned. Sixteen clones were sequenced and found to represent rat lung ZF

APA, Harvard, Vancouver, ISO, and other styles

34

Wippel, Helisa H., Mariana Fioramonte, Juan D. Chavez, and James E. Bruce. "Deciphering the architecture and interactome of hnRNP proteins and enigmRBPs." Molecular Omics 17, no. 4 (2021): 503–16. http://dx.doi.org/10.1039/d1mo00024a.

Full text

Abstract:

RNA-binding proteins (RBPs) have conserved domains and consensus sequences that interact with RNAs and other regulatory proteins forming ribonucleoprotein (RNP) complexes. Chemical crosslinking of proteins provides insights into RNP complexes interactome and protein conformations.

APA, Harvard, Vancouver, ISO, and other styles

35

FRANCESCHETTI, Marina, Colin HANFREY, Sonia SCARAMAGLI, et al. "Characterization of monocot and dicot plant S-adenosyl-l-methionine decarboxylase gene families including identification in the mRNA of a highly conserved pair of upstream overlapping open reading frames." Biochemical Journal 353, no. 2 (2001): 403–9. http://dx.doi.org/10.1042/bj3530403.

Full text

Abstract:

S-Adenosyl-L-methionine decarboxylase (AdoMetDC; EC 4.1.1.50) is one of the key regulatory enzymes in the biosynthesis of polyamines. Isolation of genomic and cDNA sequences from rice and Arabidopsis had indicated that this enzyme is encoded by a small multigene family in monocot and dicot plants. Analysis of rice, maize and Arabidopsis AdoMetDC cDNA species revealed that the monocot enzyme possesses an extended C-terminus relative to dicot and human enzymes. Interestingly, we discovered that all expressed plant AdoMetDC mRNA 5´ leader sequences contain a highly conserved pair of overlapping u

APA, Harvard, Vancouver, ISO, and other styles

36

Burt, D. W., I. R. Paton та B. R. Dey. "Comparative analysis of human and chicken transforming growth factor-β2 and -β3 promoters". Journal of Molecular Endocrinology 7, № 3 (1991): 175–83. http://dx.doi.org/10.1677/jme.0.0070175.

Full text

Abstract:

ABSTRACT The promoters for chicken transforming growth factor-β2 (TGF-β2) and TGF-β3 were cloned and sequenced to study the regulation of these genes. The promoters are GC-rich and lie within CpG islands. Several putative DNA regulatory sequence motifs were identified in the 5′-flanking regions, including matches to particular recognition sequences for several nuclear factors found in other genes. A comparison of chicken and human TGF-β2 promoters revealed a 111 bp conserved sequence surrounding the major transcription start site. Two regions of sequence homology were detected in the 5′-flanki

APA, Harvard, Vancouver, ISO, and other styles

37

C, MAHENDRA, KUMAR NUPUR HRISHIKESHAN, AHMED MOHAMMED ISMAIL, PRADEEP KUMAR JAIN, KISHOR GAIKWAD, and KANIKA KUMAR. "Evolutionary conservation of salinity responsive miRNAs from Indian wheat (Triticum aestivum) landrace, Kharchia Local." Indian Journal of Agricultural Sciences 94, no. 12 (2024): 1285–92. https://doi.org/10.56093/ijas.v94i12.147730.

Full text

Abstract:

Being temporal, majority of abiotic stresses induces responses in plants that needs to be regulated in energy efficient manner. These regulations are carried out by many regulatory molecules including microRNAs and transcription factors. Like protein coding genes, miRNAs are also conserved across the plant species to exhibit their conserved function during growth, development and response to biotic or abiotic stresses. The present study was carried out during 2020 and 2021 at National phytotron facility, ICAR-Indian Agricultural Research Institute, New Delhi. Control and salinity treated plant

APA, Harvard, Vancouver, ISO, and other styles

38

Curtis, Kristopher M., Boyd Yount, Amy C. Sims, and Ralph S. Baric. "Reverse Genetic Analysis of the Transcription Regulatory Sequence of the Coronavirus Transmissible Gastroenteritis Virus." Journal of Virology 78, no. 11 (2004): 6061–66. http://dx.doi.org/10.1128/jvi.78.11.6061-6066.2004.

Full text

Abstract:

ABSTRACT Coronavirus discontinuous transcription uses a highly conserved sequence (CS) in the joining of leader and body RNAs. Using a full-length infectious construct of transmissable gastroenteritis virus, the present study demonstrates that subgenomic transcription is heavily influenced by upstream flanking sequences and supports a mechanism of transcription attenuation that is regulated in part by a larger domain composed of primarily upstream flanking sequences which select appropriately positioned CS elements for synthesis of subgenomic RNAs.

APA, Harvard, Vancouver, ISO, and other styles

39

Guo, Hena, and Stephen P. Moose. "Conserved Noncoding Sequences among Cultivated Cereal Genomes Identify Candidate Regulatory Sequence Elements and Patterns of Promoter Evolution." Plant Cell 15, no. 5 (2003): 1143–58. http://dx.doi.org/10.1105/tpc.010181.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Nugent, J. H., C. E. Alfa, T. Young, and J. S. Hyams. "Conserved structural motifs in cyclins identified by sequence analysis." Journal of Cell Science 99, no. 3 (1991): 669–74. http://dx.doi.org/10.1242/jcs.99.3.669.

Full text

Abstract:

Cyclins, as regulatory subunits of the ubiquitous p34cdc2 protein kinase, act as key controlling elements of the eukaryotic cell cycle. We have examined published sequences of A- and B-type cyclins for both amino acid and secondary structure homologies. In particular, we sought regions of homology outside the recognised area of sequence conservation known as the “cyclin box”, as well as conserved features predicted to lie at the protein surface. Our analysis demonstrates the existence of a number of islands of homology outside the cyclin box, and indicates candidate residues for phosphorylatio

APA, Harvard, Vancouver, ISO, and other styles

41

Puppo, Francesca, Marco Musso, Doroti Pirulli, et al. "Comparative genomic sequence analysis coupled to chromatin immunoprecipitation: a screening procedure applied to search for regulatory elements at the RET locus." Physiological Genomics 23, no. 3 (2005): 269–74. http://dx.doi.org/10.1152/physiolgenomics.00036.2005.

Full text

Abstract:

RET gene expression is characterized by high tissue and stage specificity during the development of neural crest derivatives and in the pathogenesis of inherited cancer syndromes and Hirschsprung disease. Identifying all elements contributing to its transcriptional regulation might provide new clues to clarify both developmental and pathogenic mechanisms. We previously demonstrated that chromatin acetylation affects RET transcription; therefore, we have set up a strategy based on analysis of sequences conserved among species at the RET locus, combined with the characterization of their chromat

APA, Harvard, Vancouver, ISO, and other styles

42

Wong, Emily S., Dawei Zheng, Siew Z. Tan, et al. "Deep conservation of the enhancer regulatory code in animals." Science 370, no. 6517 (2020): eaax8137. http://dx.doi.org/10.1126/science.aax8137.

Full text

Abstract:

Interactions of transcription factors (TFs) with DNA regulatory sequences, known as enhancers, specify cell identity during animal development. Unlike TFs, the origin and evolution of enhancers has been difficult to trace. We drove zebrafish and mouse developmental transcription using enhancers from an evolutionarily distant marine sponge. Some of these sponge enhancers are located in highly conserved microsyntenic regions, including an Islet enhancer in the Islet-Scaper region. We found that Islet enhancers in humans and mice share a suite of TF binding motifs with sponges, and that they driv

APA, Harvard, Vancouver, ISO, and other styles

43

Attanasio, Catia, Alexandre Reymond, Richard Humbert, et al. "Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells." Genome Biology 9, no. 12 (2008): R168. http://dx.doi.org/10.1186/gb-2008-9-12-r168.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Merighi, Massimo, Doris R. Majerczak, Michael Zianni, Kimberly Tessanne, and David L. Coplin. "Molecular Characterization of Pantoea stewartii subsp. stewartii HrpY, a Conserved Response Regulator of the Hrp Type III Secretion System, and its Interaction with the hrpS Promoter." Journal of Bacteriology 188, no. 14 (2006): 5089–100. http://dx.doi.org/10.1128/jb.01929-05.

Full text

Abstract:

ABSTRACT Pantoea stewartii subsp. stewartii is a bacterial pathogen of corn. Its pathogenicity depends on the translocation of effector proteins into host cells by the Hrp type III secretion system. We previously showed by genetic analysis that the HrpX sensor kinase and the HrpY response regulator are at the head of a complex cascade of regulators controlling hrp/hrc secretion and wts effector genes. This cascade also includes the HrpS response regulator and the HrpL alternative sigma factor. These regulators are shared among many important plant pathogens in the genera Pantoea, Erwinia, and

APA, Harvard, Vancouver, ISO, and other styles

45

Langham, Richard J., Justine Walsh, Molly Dunn, Cynthia Ko, Stephen A. Goff, and Michael Freeling. "Genomic Duplication, Fractionation and the Origin of Regulatory Novelty." Genetics 166, no. 2 (2004): 935–45. http://dx.doi.org/10.1093/genetics/166.2.935.

Full text

Abstract:

Abstract Having diverged 50 MYA, rice remained diploid while the maize lineage became tetraploid and then fractionated by losing genes from one or the other duplicate region. We sequenced and annotated 13 maize genes (counting the duplicate gene as one gene) on one or the other of the pair of homeologous maize regions; 12 genes were present in one cluster in rice. Excellent maize-rice synteny was evident, but only after the fractionated maize regions were condensed onto a finished rice map. Excluding the gene we used to define homeologs, we found zero retention. Once retained, fractionation (l

APA, Harvard, Vancouver, ISO, and other styles

46

Tanabe, O., S. Akira, T. Kamiya, G. G. Wong, T. Hirano, and T. Kishimoto. "Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human." Journal of Immunology 141, no. 11 (1988): 3875–81. http://dx.doi.org/10.4049/jimmunol.141.11.3875.

Full text

Abstract:

Abstract The genomic clone of mouse IL-6 was isolated and compared with the human IL-6 gene. The comparison revealed that the mouse IL-6 consists of five exons and four introns and that the overall organization is similar to that of the human IL-6 gene although the third intron is about 2 kb longer. The sequence similarity in the coding region is about 60%, whereas the 3'-untranslated region and the first 300-bp sequence of the 5'-flanking region are highly conserved (greater than 80%). Several sequence blocks with high homology are also found in the introns. Furthermore, sequences similar to

APA, Harvard, Vancouver, ISO, and other styles

47

Wang, Jianrong, Cristina Vicente-García, Davide Seruggia, et al. "MIR retrotransposon sequences provide insulators to the human genome." Proceedings of the National Academy of Sciences 112, no. 32 (2015): E4428—E4437. http://dx.doi.org/10.1073/pnas.1507253112.

Full text

Abstract:

Insulators are regulatory elements that help to organize eukaryotic chromatin via enhancer-blocking and chromatin barrier activity. Although there are several examples of transposable element (TE)-derived insulators, the contribution of TEs to human insulators has not been systematically explored. Mammalian-wide interspersed repeats (MIRs) are a conserved family of TEs that have substantial regulatory capacity and share sequence characteristics with tRNA-related insulators. We sought to evaluate whether MIRs can serve as insulators in the human genome. We applied a bioinformatic screen using g

APA, Harvard, Vancouver, ISO, and other styles

48

Fish, Richard J., and Marguerite Neerman-Arbez. "A novel regulatory element between the human FGA and FGG genes." Thrombosis and Haemostasis 108, no. 09 (2012): 427–34. http://dx.doi.org/10.1160/th12-04-0274.

Full text

Abstract:

SummaryHigh circulating fibrinogen levels correlate with cardiovascular disease (CVD) risk. Fibrinogen levels vary between people and also change in response to physiological and environmental stimuli. A modest proportion of the variation in fibrinogen levels can be explained by genotype, inferring that variation in genomic sequences that regulate the fibri-nogen genes (FGA, FGB and FGG) may affect hepatic fibrinogen production and perhaps CVD risk. We previously identified a conserved liver enhancer in the fibrinogen gene cluster (CNC12), between FGB and FGA. Genome-wide Chromatin immunopreci

APA, Harvard, Vancouver, ISO, and other styles

49

Cross, Frederick R., Nicolas E. Buchler, and Jan M. Skotheim. "Evolution of networks and sequences in eukaryotic cell cycle control." Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1584 (2011): 3532–44. http://dx.doi.org/10.1098/rstb.2011.0078.

Full text

Abstract:

The molecular networks regulating the G1–S transition in budding yeast and mammals are strikingly similar in network structure. However, many of the individual proteins performing similar network roles appear to have unrelated amino acid sequences, suggesting either extremely rapid sequence evolution, or true polyphyly of proteins carrying out identical network roles. A yeast/mammal comparison suggests that network topology, and its associated dynamic properties, rather than regulatory proteins themselves may be the most important elements conserved through evolution. However, recent deep phyl

APA, Harvard, Vancouver, ISO, and other styles

50

Powell-Coffman, J. A., and R. A. Firtel. "Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences." Development 120, no. 6 (1994): 1601–11. http://dx.doi.org/10.1242/dev.120.6.1601.

Full text

Abstract:

While Dictyostelium discoideum has been studied as a developmental system for decades, and many regulatory proteins have been cloned, the molecular mechanisms of cell-type-specific gene expression are poorly understood. In this paper we characterize a novel prespore gene, PspB, and undertake a comparative analysis of the regulatory regions in prespore-specific D. discoideum promoters. Sequence alignment of the PSPB gene product with other prespore-specific proteins identifies a conserved, repeated 12 amino acid cysteine-containing motif that may be involved in spore coat function or assembly.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!