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1

Raymer, Anastasia. "Constraint-Induced Language Therapy: A Systematic Review." ASHA Leader 14, no. 2 (2009): 26–27. http://dx.doi.org/10.1044/leader.ftr4.14022009.26.

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Page, Stephen J., and Sarah E. Wallace. "Speech Language Pathologists’ Opinions of Constraint-Induced Language Therapy." Topics in Stroke Rehabilitation 21, no. 4 (2014): 332–38. http://dx.doi.org/10.1310/tsr2104-332.

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Page, Stephen, and Sarah Wallace. "Speech Language Pathologists' Opinions of Constraint-Induced Language Therapy." Archives of Physical Medicine and Rehabilitation 95, no. 10 (2014): e27. http://dx.doi.org/10.1016/j.apmr.2014.07.066.

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4

Kirmess, Melanie, and Lynn M. Maher. "Constraint induced language therapy in early aphasia rehabilitation." Aphasiology 24, no. 6-8 (2010): 725–36. http://dx.doi.org/10.1080/02687030903437682.

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5

Kirmess, Melanie, and Marianne Lind. "Spoken language production as outcome measurement following constraint induced language therapy." Aphasiology 25, no. 10 (2011): 1207–38. http://dx.doi.org/10.1080/02687038.2011.589986.

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6

Hong, Sae Mi, Jin Kyung Kang, Bora Eom, et al. "Meta-Analysis of Constraint-Induced Language Therapy in Aphasia." Communication Sciences & Disorders 21, no. 1 (2016): 162–73. http://dx.doi.org/10.12963/csd.15280.

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7

Raymer, Anastasia M., Lynn M. Maher, Janet Patterson, and Leora Cherney. "Neuroplasticity and Aphasia: Lessons from Constraint-Induced Language Therapy." Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders 17, no. 2 (2007): 12–17. http://dx.doi.org/10.1044/nnsld17.2.12.

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8

Faroqi‐Shah, Yasmeen, and Christine R. Virion. "Constraint‐induced language therapy for agrammatism: Role of grammaticality constraints." Aphasiology 23, no. 7-8 (2009): 977–88. http://dx.doi.org/10.1080/02687030802642036.

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9

Pitt, Rachelle, Deborah Theodoros, Anne J. Hill, Amy D. Rodriguez, and Trevor Russell. "The feasibility of delivering constraint-induced language therapy via the Internet." DIGITAL HEALTH 3 (January 2017): 205520761771876. http://dx.doi.org/10.1177/2055207617718767.

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10

Wilssens, Ineke, Dorien Vandenborre, Kim van Dun, Jo Verhoeven, Evy Visch-Brink, and Peter Mariën. "Constraint-Induced Aphasia Therapy Versus Intensive Semantic Treatment in Fluent Aphasia." American Journal of Speech-Language Pathology 24, no. 2 (2015): 281–94. http://dx.doi.org/10.1044/2015_ajslp-14-0018.

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Objective The authors compared the effectiveness of 2 intensive therapy methods: Constraint-Induced Aphasia Therapy (CIAT; Pulvermüller et al., 2001) and semantic therapy (BOX; Visch-Brink & Bajema, 2001). Method Nine patients with chronic fluent aphasia participated in a therapy program to establish behavioral treatment outcomes. Participants were randomly assigned to one of two groups (CIAT or BOX). Results Intensive therapy significantly improved verbal communication. However, BOX treatment showed a more pronounced improvement on two communication—namely, a standardized assessment for verbal communication, the Amsterdam Nijmegen Everyday Language Test (Blomert, Koster, & Kean, 1995), and a subjective rating scale, the Communicative Effectiveness Index (Lomas et al., 1989). All participants significantly improved on one (or more) subtests of the Aachen Aphasia Test (Graetz, de Bleser, & Willmes, 1992), an impairment-focused assessment. There was a treatment-specific effect. BOX treatment had a significant effect on language comprehension and semantics, whereas CIAT treatment affected language production and phonology. Conclusion The findings indicate that in patients with fluent aphasia, (a) intensive treatment has a significant effect on language and verbal communication, (b) intensive therapy results in selective treatment effects, and (c) an intensive semantic treatment shows a more striking mean improvement on verbal communication in comparison with communication-based CIAT treatment.
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11

Woldag, Hartwig, Nancy Voigt, Maria Bley, and Horst Hummelsheim. "Constraint-Induced Aphasia Therapy in the Acute Stage." Neurorehabilitation and Neural Repair 31, no. 1 (2016): 72–80. http://dx.doi.org/10.1177/1545968316662707.

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Background. Constraint-induced aphasia therapy (CIAT) has proven effective in patients with subacute and chronic forms of aphasia. It has remained unclear, however, whether intensity of therapy or constraint is the relevant factor. Data about intensive speech and language therapy (SLT) are conflicting. Objective. To identify the effective component of CIAT and assess the feasibility of SLT in the acute stage after stroke. Method. A total of 60 patients with aphasia (68.2 ± 11.7 years) were enrolled 18.9 days after first-ever stroke. They were randomly distributed into 3 groups: (1) CIAT group receiving therapy for 3 hours per day (10 workdays, total 30 hours); (2) conventional communication treatment group, with same intensity without constraints; and (3) control group receiving individual therapy twice a day as well as group therapy (total 14 hours). Patients were assessed pretreatment and posttreatment using the Aachener Aphasia Test (primary end point: token test) and the Communicative Activity Log (CAL). Results. Pretreatment, there were no between-group differences. Posttreatment, all groups showed significant improvements without between-group differences. Conclusion. It was found that 14 hours of aphasia therapy administered within 2 weeks as individual therapy, focusing on individual deficits, combined with group sessions has proven to be most efficient. This approach yielded the same outcome as 30 hours of group therapy, either in the form of CIAT or group therapy without constraints. SLT in an intensive treatment schedule is feasible and was well tolerated in the acute stage after stroke.
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12

Sharp, Brian, Paige Shaughnessy, Lee Berk, and Noha Daher. "Stress and language recovery in individuals with aphasia: constraint induced aphasia therapy." Physical Therapy Rehabilitation Science 2, no. 2 (2013): 92–98. http://dx.doi.org/10.14474/ptrs.2013.2.2.92.

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13

Kim, Esther S., and Kayla Paterson. "Additional doses of Constraint Induced Language Therapy (CILT) can improve outcomes in aphasia." Evidence-Based Communication Assessment and Intervention 12, no. 4 (2018): 147–51. http://dx.doi.org/10.1080/17489539.2019.1582155.

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14

Breier, Joshua I., Lynn M. Maher, Barbra Novak, and Andrew C. Papanicolaou. "Functional Imaging Before and After Constraint-Induced Language Therapy for Aphasia Using Magnetoencephalography." Neurocase 12, no. 6 (2006): 322–31. http://dx.doi.org/10.1080/13554790601126054.

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15

Mozeiko, Jennifer, Emily B. Myers, and Carl A. Coelho. "Treatment Response to a Double Administration of Constraint-Induced Language Therapy in Chronic Aphasia." Journal of Speech, Language, and Hearing Research 61, no. 7 (2018): 1664–90. http://dx.doi.org/10.1044/2018_jslhr-l-16-0102.

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PurposeThis study investigated changes in oral–verbal expressive language associated with improvements following 2 treatment periods of constraint-induced language therapy in 4 participants with stroke-induced chronic aphasia. Generalization of treatment to untrained materials and to discourse production was also analyzed, as was the durability of the treatment effect.MethodParticipants with aphasia were assessed using standardized measures and discourse tasks at 3 to 4 time points to document behavioral changes throughout each of two 30-hr treatment periods of constraint-induced language therapy. Daily probes of trained and untrained materials were also administered.ResultsDespite participant heterogeneity, behavioral results for each person with aphasia indicated a positive response to treatment following each treatment period indicated by performance on standardized tests, trained materials, or both. Treatment effects generalized to some degree to untrained stimuli and to discourse measures and were generally maintained at follow-up testing.ConclusionsData support the utility of a 2nd treatment period. Results are relevant to rehabilitation in chronic aphasia, confirming that significant language gains continue well past the point of spontaneous recovery and can occur in a relatively short time period. Importantly, changes are not confined to a single treatment period, suggesting that people with aphasia may benefit from multiple doses of high-intensity treatment.
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16

Mozeiko, Jennifer, Carl A. Coelho, and Emily B. Myers. "The role of intensity in constraint-induced language therapy for people with chronic aphasia." Aphasiology 30, no. 4 (2015): 339–63. http://dx.doi.org/10.1080/02687038.2015.1070949.

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17

Reidy, Teressa Garcia, Joan Carney, Lisa Schoenbrodt, and Frank Pidcock. "Reporting collateral effects of pediatric constraint induced movement therapy: Parent observed speech and language changes." Journal of Interprofessional Education & Practice 11 (June 2018): 58–63. http://dx.doi.org/10.1016/j.xjep.2018.02.006.

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18

Meinzer, Marcus, Daniela Djundja, Gabriela Barthel, Thomas Elbert, and Brigitte Rockstroh. "Long-Term Stability of Improved Language Functions in Chronic Aphasia After Constraint-Induced Aphasia Therapy." Stroke 36, no. 7 (2005): 1462–66. http://dx.doi.org/10.1161/01.str.0000169941.29831.2a.

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19

Balardin, Joana Bisol, and Eliane Correa Miotto. "A review of Constraint-Induced Therapy applied to aphasia rehabilitation in stroke patients." Dementia & Neuropsychologia 3, no. 4 (2009): 275–82. http://dx.doi.org/10.1590/s1980-57642009dn30400003.

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Abstract Constraint-induced aphasia therapy (CIAT) is an intensive therapy model based on the forced use of verbal oral language as the sole channel of communication, while any alternative communication mode such as writing, gesturing or pointing are prevented. Objectives: This critical review involved the analysis of studies examining CIAT applied to stroke patients. Methods and Results: Using keywords, the Medline database was searched for relevant studies published between 2001 and 2008 (Medline 2001-2008). The critical evaluation of the articles was based on the classifications described by the ASNS (Cicerone adaptation). Two studies were categorized as level Ia, two as level II and one study as level IV. Conclusions: These recommendations should be interpreted with caution, given the small number of studies involved, but serve as a guideline for future studies in aphasia therapy.
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20

Griffith, Julie, Aimee Dietz, Angel Ball, Jennifer Vannest, and Jerzy P. Szaflarski. "An examination of changes in spoken productions within constraint-induced aphasia therapy." Aphasiology 31, no. 11 (2017): 1250–65. http://dx.doi.org/10.1080/02687038.2017.1350628.

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21

Johnson, Margaret L., Edward Taub, Leslie H. Harper, et al. "An Enhanced Protocol for Constraint-Induced Aphasia Therapy II: A Case Series." American Journal of Speech-Language Pathology 23, no. 1 (2014): 60–72. http://dx.doi.org/10.1044/1058-0360(2013/12-0168).

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22

Cherney, Leora R., Janet P. Patterson, Anastasia Raymer, Tobi Frymark, and Tracy Schooling. "Evidence-Based Systematic Review: Effects of Intensity of Treatment and Constraint-Induced Language Therapy for Individuals With Stroke-Induced Aphasia." Journal of Speech, Language, and Hearing Research 51, no. 5 (2008): 1282–99. http://dx.doi.org/10.1044/1092-4388(2008/07-0206).

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23

Raymer, Anastasia, Janet Patterson, Leora Cherney, Rob Mullen, Tracy Schooling, and Tobi Frymark. "Poster 3: Examining the Effects of Treatment Intensity and Constraint-Induced Language Therapy for Persons With Stroke-Induced Aphasia: Findings of an Evidence-Based Systematic Review." Archives of Physical Medicine and Rehabilitation 88, no. 10 (2007): e7. http://dx.doi.org/10.1016/j.apmr.2007.08.042.

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24

Rose, Miranda L., Michelle C. Attard, Zaneta Mok, Lucette E. Lanyon, and Abby M. Foster. "Multi-modality aphasia therapy is as efficacious as a constraint-induced aphasia therapy for chronic aphasia: A phase 1 study." Aphasiology 27, no. 8 (2013): 938–71. http://dx.doi.org/10.1080/02687038.2013.810329.

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25

Hameister, Inga, Lyndsey Nickels, Stefanie Abel, and Karen Croot. "“Do you havemowing the lawn?” – improvements in word retrieval and grammar following constraint-induced language therapy in primary progressive aphasia." Aphasiology 31, no. 3 (2016): 308–31. http://dx.doi.org/10.1080/02687038.2016.1197558.

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26

Maul, Kristen K., Peggy S. Conner, Daniel Kempler, Christina Radvanski, and Mira Goral. "Using Informative Verbal Exchanges to Promote Verb Retrieval in Nonfluent Aphasia." American Journal of Speech-Language Pathology 23, no. 3 (2014): 407–20. http://dx.doi.org/10.1044/2014_ajslp-13-0004.

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PurposeThe goal of this study was to determine whether positive treatment effects of a modified constraint-induced language therapy focused on verb production would generalize to unpracticed items and tasks.MethodFour individuals participated in a single-subject treatment design protocol. The treatment involved intensive practice producing verbs in sentences in an informative communicative exchange. Direct treatment outcome was examined by measuring the accuracy of producing practiced verbs in an action description task, a task similar to those used in treatment. Generalization was assessed by measuring production of unpracticed verbs and sentence grammaticality in the action description task and by measuring verb production and sentence grammaticality in 2 relatively unstructured (unpracticed) language tasks.ResultsTwo of the 4 participants showed a direct treatment effect, producing a greater number of practiced verbs in the action description task following treatment compared with before treatment. All participants improved sentence grammaticality following treatment, although grammaticality was not explicitly targeted in therapy. Generalization to unpracticed, less-structured tasks was variable across the participants.ConclusionPatterns of generalization may depend on participants' specific language deficits and production characteristics, on the language tasks used, and on the measures used to detect change and assess generalization.
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27

Cichon, Natalia, Lidia Wlodarczyk, Joanna Saluk-Bijak, et al. "Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation." Journal of Clinical Medicine 10, no. 17 (2021): 3778. http://dx.doi.org/10.3390/jcm10173778.

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Aphasia is one of the most common clinical features of functional impairment after a stroke. Approximately 21–40% of stroke patients sustain permanent aphasia, which progressively worsens one’s quality of life and rehabilitation outcomes. Post-stroke aphasia treatment strategies include speech language therapies, cognitive neurorehabilitation, telerehabilitation, computer-based management, experimental pharmacotherapy, and physical medicine. This review focuses on current evidence of the effectiveness of impairment-based aphasia therapies and communication-based therapies (as well as the timing and optimal treatment intensities for these interventions). Moreover, we present specific interventions, such as constraint-induced aphasia therapy (CIAT) and melodic intonation therapy (MIT). Accumulated data suggest that using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is safe and can be used to modulate cortical excitability. Therefore, we review clinical studies that present TMS and tDCS as (possible) promising therapies in speech and language recovery, stimulating neuroplasticity. Several drugs have been used in aphasia pharmacotherapy, but evidence from clinical studies suggest that only nootropic agents, donepezil and memantine, may improve the prognosis of aphasia. This article is an overview on the current state of knowledge related to post-stroke aphasia pharmacology, rehabilitation, and future trends.
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ROMAN-FILIP, Corina, and Maria-Gabriela CATANĂ. "Stroke in young adults – a challenge for etiology, treatment and rehabilitation." Balneo Research Journal, Vol.11, no.4 (December 5, 2020): 425–29. http://dx.doi.org/10.12680/balneo.2020.373.

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Strokes occur rarely in individuals under the age of 45 and are even more uncommon under the age of 30, the etiology of this pathology in young adults being generally related to unknown or unusual causes. We present the cases of three young adults that suffered strokes with three different unusual etiologies. The three men were 30, 36 and 43 years old, with no pathological antecedents, with neurological symptoms characteristic for stroke. Because the differential diagnostics are sometimes tricky, in all three cases imagery was very helpful. It is necessary to emphasize that in these cases one of the most important things to know is the etiology. It is very important to treat the effect too; this is the reason why we never miss an opportunity to use alteplase when all conditions are met. Common rehabilitation regimes for young adults, who have suffered a stroke, include a combination of physiotherapy, occupational therapy, speech-language therapy, and pharmacological therapy. Strategies to improve motor recovery in young patients include constraint-induced movement therapy, robot-aided rehabilitation, virtual reality training, functional electrical stimulation, increased exercise intensity, and acupuncture. Keywords: stroke, young patients, etiology, thrombophilia, drugs abuse, artery dissection, rehabilitation,
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Rose, Miranda L., John Pierce, Maya Menahemi-Falkov, Robyn O’Halloran, and Leanne Togher. "Does constraint-induced aphasia therapy or multimodal aphasia therapy lead to better outcomes for people with chronic post-stroke aphasia? A review of latest evidence and rationale for the COMPARE clinical trial." Aphasiology 32, sup1 (2018): 178–79. http://dx.doi.org/10.1080/02687038.2018.1485844.

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30

Dembowski, James S. "Available studies fail to disambiguate contributions of language modality constraint and treatment intensity to effects of constraint-induced language therapy1." Evidence-Based Communication Assessment and Intervention 3, no. 2 (2009): 72–78. http://dx.doi.org/10.1080/17489530903080612.

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31

MAHER, LYNN M., DIANE KENDALL, JENNIFER A. SWEARENGIN, et al. "A pilot study of use-dependent learning in the context of Constraint Induced Language Therapy." Journal of the International Neuropsychological Society 12, no. 06 (2006). http://dx.doi.org/10.1017/s1355617706061029.

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32

Dreyer, Felix R., Lea Doppelbauer, Verena Büscher, et al. "Increased Recruitment of Domain-General Neural Networks in Language Processing Following Intensive Language-Action Therapy: fMRI Evidence From People With Chronic Aphasia." American Journal of Speech-Language Pathology, August 19, 2020, 1–11. http://dx.doi.org/10.1044/2020_ajslp-19-00150.

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Purpose This study aimed to provide novel insights into the neural correlates of language improvement following intensive language-action therapy (ILAT; also known as constraint-induced aphasia therapy). Method Sixteen people with chronic aphasia underwent clinical aphasia assessment (Aachen Aphasia Test [AAT]), as well as functional magnetic resonance imaging (fMRI), both administered before (T1) and after ILAT (T2). The fMRI task included passive reading of single written words, with hashmark strings as visual baseline. Results Behavioral results indicated significant improvements of AAT scores across therapy, and fMRI results showed T2–T1 blood oxygenation-level-dependent (BOLD) signal change in the left precuneus to be modulated by the degree of AAT score increase. Subsequent region-of-interest analysis of this precuneus cluster confirmed a positive correlation of T2–T1 BOLD signal change and improvement on the clinical aphasia test. Similarly, the entire default mode network revealed a positive correlation between T2–T1 BOLD signal change and clinical language improvement. Conclusion These results are consistent with a more efficient recruitment of domain-general neural networks in language processing, including those involved in attentional control, following aphasia therapy with ILAT. Supplemental Material https://doi.org/10.23641/asha.12765755
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33

Rose, Miranda L. "Releasing the Constraints on Aphasia Therapy: The Positive Impact of Gesture and Multimodality Treatments." American Journal of Speech-Language Pathology 22, no. 2 (2013). http://dx.doi.org/10.1044/1058-0360(2012/12-0091).

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PurposeThere is a 40-year history of interest in the use of arm and hand gestures in treatments that target the reduction of aphasic linguistic impairment and compensatory methods of communication (Rose, 2006). Arguments for constraining aphasia treatment to the verbal modality have arisen from proponents of constraint-induced aphasia therapy (Pulvermüller et al., 2001). Confusion exists concerning the role of nonverbal treatments in treating people with aphasia. The central argument of this paper is that given the state of the empirical evidence and the strong theoretical accounts of modality interactions in human communication, gesture-based and multimodality aphasia treatments are at least as legitimate an option as constraint-based aphasia treatment.MethodTheoretical accounts of modality interactions in human communication and the gesture production abilities of individuals with aphasia that are harnessed in treatments are reviewed. The negative effects on word retrieval of restricting gesture production are also reviewed, and an overview of the neurological architecture subserving language processing is provided as rationale for multimodality treatments. The evidence for constrained and unconstrained treatments is critically reviewed.ConclusionTogether, these data suggest that constraint treatments and multimodality treatments are equally efficacious, and there is limited support for constraining client responses to the spoken modality.
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34

Mohr, Bettina, Stephanie Difrancesco, Karen Harrington, Samuel Evans, and Friedemann Pulvermüller. "Changes of right-hemispheric activation after constraint-induced, intensive language action therapy in chronic aphasia: fMRI evidence from auditory semantic processing1." Frontiers in Human Neuroscience 8 (November 14, 2014). http://dx.doi.org/10.3389/fnhum.2014.00919.

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35

Allendorfer, Jane B., Rodolphe Nenert, Sangeeta Nair, Jennifer Vannest, and Jerzy P. Szaflarski. "Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia." Medical Science Monitor 27 (March 19, 2021). http://dx.doi.org/10.12659/msm.930100.

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