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Journal articles on the topic 'Contact localizations'

Author: Grafiati

Published: 1 June 2024

Last updated: 19 July 2025

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1

Stevenson, B. R., M. B. Heintzelman, J. M. Anderson, S. Citi, and M. S. Mooseker. "ZO-1 and cingulin: tight junction proteins with distinct identities and localizations." American Journal of Physiology-Cell Physiology 257, no. 4 (1989): C621—C628. http://dx.doi.org/10.1152/ajpcell.1989.257.4.c621.

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The relative localization of ZO-1 and cingulin, the only two known components of the tight junction, was compared in Madin-Darby canine kidney (MDCK) cells, chicken small intestine, rat kidney distal convoluted tubule, and a hepatoma cell line. Immunoblot analysis demonstrated that cingulin and ZO-1 are immunologically unrelated and that, in the colon, cingulin is a single polypeptide with a molecular mass of 140 kDa. Immunofluorescent localization of cingulin and ZO-1 in confluent monolayers of MDCK cells showed identical staining patterns. However, subconfluent MDCK cells showed distinct loc

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Abbass, M., G. Gilmore, A. Chalil, et al. "P.124 Subnuclear contact localization within the subthalamic nucleus in deep brain stimulation for Parkinson Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 49, s1 (2022): S41. http://dx.doi.org/10.1017/cjn.2022.215.

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Background: Therapeutic response from subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD) has been associated with proximity to an ideal target, commonly in the dorsal sensorimotor STN. Automated registration and atlas-based segmentation has allowed for contact localization within STN subnuclei. We sought to apply these methods to characterize the spatial distribution of our active contact placements. Methods: We conducted a retrospective analysis of 55 patients who underwent bilateral STN DBS for PD. Post-operative CT/MRI scans were non-linearly registered into a

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Lai, Van-Vuong, Igor Paszkiewicz, Jean-François Brunel, and Philippe Dufrénoy. "Multi-Scale Contact Localization and Dynamic Instability Related to Brake Squeal." Lubricants 8, no. 4 (2020): 43. http://dx.doi.org/10.3390/lubricants8040043.

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Friction-induced vibrations (brake squeal) produced during braking applications have been one of the major problems in the transportation for many years. It can be the most troublesome for passengers because of its high frequency and acoustic pressure. The role of frictional contact surface geometry on the occurrence of squeal was investigated recently by some researchers. However, it has never been systematically studied at different scales simultaneously. Contact localizations are induced on the one hand by macro effects such as thermal dilatation (macroscopic scale) and on the other hand, b

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Pöllänen, J., O. Saksela, EM Salonen, et al. "Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells." Journal of Cell Biology 104, no. 4 (1987): 1085–96. http://dx.doi.org/10.1083/jcb.104.4.1085.

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We studied the immunocytochemical localization of urokinase-type plasminogen activator (u-PA) and the type 1 plasminogen activator inhibitor (PAI-1) in human fibroblasts and sarcoma cells, using both polyclonal and monoclonal antibodies. The u-PA was found to be located at discrete cell-substratum contact sites, and also at areas of cell-cell contacts, whereas PAI-1 was distributed as a homogeneous carpet excluding strialike areas on the substrate under the cells. To confirm the extracellular localization of u-PA and PAI-1, we stained the cells live at 0 degree C before fixation. A double-labe

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Pöllänen, J., K. Hedman, L. S. Nielsen, K. Danø, and A. Vaheri. "Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts." Journal of Cell Biology 106, no. 1 (1988): 87–95. http://dx.doi.org/10.1083/jcb.106.1.87.

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We have recently shown that urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor type 1 are both found extracellularly beneath cultured human skin fibroblasts and HT-1080 sarcoma cells, but in distinct localizations. Here, the ultrastructural distribution of u-PA was studied using immunoferritin electron microscopy. In HT-1080 cells, u-PA on the extracellular aspect of the plasma membrane was detected at sites of direct contact of the cell with the growth substratum beneath all parts of the ventral cell surface. The ferritin-labeled adhesion plaques, which were enric

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Huang, Guozhong, Mayara S. Bertolini, Justin Wiedeman, Ronald D. Etheridge, Teresa Cruz-Bustos, and Roberto Docampo. "Lysosome and plasma membrane Piezo channels of Trypanosoma cruzi are essential for proliferation, differentiation and infectivity." PLOS Pathogens 21, no. 4 (2025): e1013105. https://doi.org/10.1371/journal.ppat.1013105.

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Trypanosoma cruzi, the causative agent of Chagas disease, is a parasitic protist that affects millions of people worldwide. Currently there are no fully effective drugs or vaccines available. Contact of T. cruzi infective forms with their host cells or with the extracellular matrix increases their intracellular Ca2+ concentration suggesting a mechano-transduction process. We report here that T. cruzi possesses two distinct mechanosensitive Piezo channels, named TcPiezo1 and TcPiezo2, with different subcellular localizations but similarly essential for normal proliferation, differentiation, and

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Gao, Mingming, and Hongyuan Yang. "VPS13: A lipid transfer protein making contacts at multiple cellular locations." Journal of Cell Biology 217, no. 10 (2018): 3322–24. http://dx.doi.org/10.1083/jcb.201808151.

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The evolutionarily conserved VPS13 proteins localize to multiple membrane contact sites though their function and regulation has been elusive. Bean et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201804111) found that competitive adaptors control the different localizations of yeast Vps13p, while Kumar et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201807019) provide biochemical and structural evidence for VPS13 proteins in the nonvesicular transport of phospholipids.

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Bolivar, I., and J. Guiard-Maffia. "Cellular localization of the SerH surface antigen in Tetrahymena thermophila." Journal of Cell Science 94, no. 2 (1989): 343–54. http://dx.doi.org/10.1242/jcs.94.2.343.

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We have purified the SerH surface antigen of T. thermophila by a novel and simple procedure and produced specific antisera against it. By the use of various immunochemical techniques, we have investigated the intracellular distribution of the antigen and shown that SerH is not only abundant in the cortex but also in the digestive apparatus of the ciliate. In each of these two localizations, SerH occupies a variety of compartments: in the cortex it can be found in the surface coat, the exocytotic mucocysts, the endocytotic parasomal sacs and as an integral protein of the membrane; in the digest

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Ndour, Mamour, and Birahim Gueye. "Mlouma: to connect the agricultural products market players." Emerald Emerging Markets Case Studies 6, no. 3 (2016): 1–18. http://dx.doi.org/10.1108/eemcs-10-2016-0276.

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Subject area Social entrepreneurship/social innovation. Study level/applicability This real case targets license and master’s students as part of an ongoing course on social entrepreneurship, social innovation, in one word, on entrepreneurship. Case overview Mlouma is a platform based on Web, SMS, USSD, mobile application and call center. This social enterprise keeps farmers in contact with food buyers by displaying real-time market prices and localizations. The service will improve the efficiency of the agriculture supply chain, helping farmers to get a better price for their product. By intr

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Arango-Argoty, G. A., J. A. Jaramillo-Garzón, and G. Castellanos-Domínguez. "Feature extraction by statistical contact potentials and wavelet transform for predicting subcellular localizations in gram negative bacterial proteins." Journal of Theoretical Biology 364 (January 2015): 121–30. http://dx.doi.org/10.1016/j.jtbi.2014.08.051.

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Frangieh, Joseph, Yannick Desplanques, Ruddy Mann, and Philippe Dufrenoy. "Downscaling for disc-brake wear testing using a thermomechanical approach." Mechanics & Industry 24 (2023): 24. http://dx.doi.org/10.1051/meca/2023016.

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Brake wear has been identified to be an important source of non-exhaust emissions in transportation. The high dissipated energy in the contact not only results in large frictional heat dissipation in the brake components but also in the generation of debris, particles and gases produced by the wear of both pads and disc. Numerical simulation or tribological tests at the material scale are still not sufficient to predict wear. Experiments at the original scale of the brake system are necessary, with a significant implementation time, high costs and with a limited scope. The aim of the present w

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Kazancioglu, Rumeyza, Banu Buyukaydin, Meryem Iraz, Murat Alay, and Reha Erkoc. "An unusual cause of peritonitis in peritoneal dialysis patients: Pantoea agglomerans." Journal of Infection in Developing Countries 8, no. 07 (2014): 919–22. http://dx.doi.org/10.3855/jidc.3785.

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Peritonitis is a serious infection and early diagnosis and treatment is mandatory. A variety of microorganisms are identified in these cases and during recent years a new one was included, Pantoea agglomerans. In this case report, a female patient on continuous ambulatory peritoneal dialysis therapy with a peritonitis episode caused by this organism is described. The source of infection was thought to be due to contact of catheter with non-sterile surfaces. In microbiologic culture, this organism was identified and the patient successfully treated with a three week course of gentamicin therapy

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Soper, Daniel J., Dustine Reich, Alex Ross, et al. "Modular pipeline for reconstruction and localization of implanted intracranial ECoG and sEEG electrodes." PLOS ONE 18, no. 7 (2023): e0287921. http://dx.doi.org/10.1371/journal.pone.0287921.

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Implantation of electrodes in the brain has been used as a clinical tool for decades to stimulate and record brain activity. As this method increasingly becomes the standard of care for several disorders and diseases, there is a growing need to quickly and accurately localize the electrodes once they are placed within the brain. We share here a protocol pipeline for localizing electrodes implanted in the brain, which we have applied to more than 260 patients, that is accessible to multiple skill levels and modular in execution. This pipeline uses multiple software packages to prioritize flexib

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Mordyk, A. V., A. A. Turitsa, A. V. Kondrya, Anna R. Aroyan, and E. A. Tsygankova. "Identification of different shapes and localizations of tuberculosis in children of different ages: the role of screening examination." Russian Pediatric Journal 19, no. 3 (2019): 151–56. http://dx.doi.org/10.18821/1560-9561-2016-19-3-151-156.

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There was performed an analysis of the age structure of clinical forms of tuberculosis in children aged from 0 to 14 years. The most favorable structure of clinicalforms in children ofpreschool age was established to be characterized by absolute predominance of tuberculosis of intrathoracic lymph nodes (TILN), the minimum number of complications and generalized processes. The greatest number of the diseasedfor the 25-year period of observation was consisted of children ofprimary school age. The main method of detection of tuberculosis in children remained to be screening annual examination wit

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Mester, Bastian, Patric Kröpil, Tobias Gensior, Tobias Ohmann, and Christian Schoepp. "Do localization and appeareance of bone bruise influence the subjective short-term outcome after ACL reconstruction?" Orthopaedic Journal of Sports Medicine 8, no. 5_suppl4 (2020): 2325967120S0029. http://dx.doi.org/10.1177/2325967120s00291.

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Aims and Objectives: Large external forces in anterior cruciate ligament (ACL) injury mechanisms cause a traumatic impact between femur and tibia. Apart from concomitant intraarticular injuries like meniscal tears and chondral lesions, MRI shows a high prevalence of femorotibial bone bruise (BB) without the arthroscopic proof of macroscopic chondral defects. In recent literature, controversial results are described concerning the association between BB and subjective outcome after ACL injury. There is very limited data for the results following ACL reconstruction. Aim of this study is the eval

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Chew, Catherine S., Curtis T. Okamoto, Xunsheng Chen, and Hai Yan Qin. "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 2 (2005): G376—G387. http://dx.doi.org/10.1152/ajpgi.00290.2004.

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IQGAPs, GTPase-activating proteins with an IQ motif, are thought to regulate many actin cytoskeleton-based activities through interactions with Cdc42 and Rac. Recently, Cdc42 was implicated in regulation of gastric parietal cell HCl secretion, and IQGAP2 was immunolocalized with Cdc42 to F-actin-rich intracellular canalicular membranes of isolated gastric parietal cells in primary culture. Here we sought to define distribution and localization of IQGAP1 and IQGAP2 in major oxyntic (acid-secreting) gastric mucosal cell types and to determine whether secretory agonists modulate these proteins. D

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de Gabory, L., R. Bareille, R. Daculsi, et al. "Carbon nanotubes have a deleterious effect on the nose: the first in vitro data." Rhinology journal 49, no. 4 (2011): 445–52. http://dx.doi.org/10.4193/rhino10.256.

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Background: The information currently available concerning carbon nanotubes toxicity is disturbing and conflicting. Moreover, little is known about their effect on the nasal cavities, which are the first target for nanoparticles. Material and method: We investigated the cytotoxicity (50 to 0.5 microg/mL) of double-walled carbon nanotube with two independent tests (MTT, Wst-1) on normal human nasal epithelial cells after 12-day exposure (control untreated nasal cells and A549). Nasal cell differentiation function, oxidative stress, the morphological features of cells in contact with DWCNTs and

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Pachuliya, Zaur V., Mikhail V. Paronnikov, and Vladimir V. Protoshchak. "Current approaches to the selection of treatment methods for patients with upper ureteral stones." Urology reports (St. - Petersburg) 15, no. 1 (2025): 89–99. https://doi.org/10.17816/uroved630088.

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Urolithiasis occupies one of the leading places in the structure of urological diseases. In this case, ureterolithiasis is observed in at least 50% of cases. Of all the localizations of stones in the ureter, the most difficult problem is stones in the upper third, since with this location of the calculus, a wide range of treatment methods with different effectiveness and safety profiles can be selected. The review includes modern publications on studies of the effectiveness of conservative and surgical methods of treating patients with stones in the upper third of the ureter, including lithoki

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Izmerova, Natalia I., Ludmila P. Kuzmina, and Ilona Ya Chistova. "Pathological changes on the skin due to the combined effects of polycyclic aromatic hydrocarbons and ultraviolet radiation." Russian Journal of Occupational Health and Industrial Ecology 64, no. 10 (2024): 659–65. http://dx.doi.org/10.31089/1026-9428-2024-64-10-659-665.

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Introduction. In the National Healthcare Project, one of the key areas is the federal project "Fight against oncological diseases for 2019-2024". The influence of the nature of work activities of workers in contact with industrial carcinogens — polycyclic aromatic hydrocarbons (PAHs) significantly increases the risk of skin neoplasms, as evidenced by differences in the frequency of their occurrence among representatives of different labor categories. The leading factor in the development of skin neoplasms is ultraviolet radiation (UV) of the A and B spectrum. There is literature evidence of a

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Trukhan, Dmitry I., and Darya S. Ivanova. "Hydrolyzed marine collagen in complex therapy of degenerative-dystrophic changes in the mustocular system." Clinical review for general practice 4, no. 8 (2023): 60–67. http://dx.doi.org/10.47407/kr2023.4.8.00332.

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Degenerative-dystrophic changes in the musculoskeletal system of various localizations are one of the most common reasons for patients to turn not only to a rheumatologist, but also to a neurologist and first-contact doctors (therapist and general practitioner) who provide primary health care. Medicines that modify the symptoms of degenerative-dystrophic changes in the musculoskeletal system are divided into “fast-acting” (analgesics, NSAIDs, tramadol) and “slow-acting” (chondroprotectors). When considering “slow-acting” drugs, many publications are devoted to the natural components of the car

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Wan, Chang-Feng, Li-Gang Sun, Hai-Long Qin, Zhong-Nan Bi, and Dong-Feng Li. "A Molecular Dynamics Study on the Dislocation-Precipitate Interaction in a Nickel Based Superalloy during the Tensile Deformation." Materials 16, no. 18 (2023): 6140. http://dx.doi.org/10.3390/ma16186140.

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In the present paper, the dislocation-precipitate interaction in the Inconel 718 superalloy is studied by means of molecular dynamics simulation. The atomistic model composed of the ellipsoidal Ni3Nb precipitate (γ″ phase) and the Ni matrix is constructed, and tensile tests on the composite Ni3Nb@Ni system along different loading directions are simulated. The dislocation propagation behaviors in the precipitate interior and at the surface of the precipitate are characterized. The results indicate that the dislocation shearing and bypassing simultaneously occur during plastic deformation. The c

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Zenchenko, S. S. "Generation of interference in the surface layer at horizontal sounding of sea surface by infrared sight channels and devices." Transactions of the Krylov State Research Centre 2, no. 404 (2023): 158–64. http://dx.doi.org/10.24937/2542-2324-2023-2-404-158-164.

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Object and purpose of research. The object of investigation is specific temperatures at the water/air interface (skin layer of water). The purpose is to study the interrelation of dynamics in humidity variations of surface atmospheric layer and particulars of the media interface. Subject matter and methods. Infrared thermal imagers are employed with monitoring of the parameters of atmospheric layer adjacent to ocean surface using a multi-channel thermal hygrometer and contact temperature sensors placed in water and near-water air layer. Laboratory rigs of different scales simulating various le

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Briesewitz, R., A. Kern, and E. E. Marcantonio. "Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domain." Molecular Biology of the Cell 4, no. 6 (1993): 593–604. http://dx.doi.org/10.1091/mbc.4.6.593.

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Many integrin receptors localize to focal contact sites upon binding their ligand. However, unoccupied integrin receptors do not localize to focal contact sites. Because the integrin beta 1 cytoplasmic domain appears to have a focal contact localization signal, there must be a mechanism by which this domain is kept inactive in the unoccupied state and becomes exposed or activated in the occupied receptor. We considered that this mechanism involves the alpha subunit cytoplasmic domain. To test this hypothesis, we have established two NIH 3T3 cell lines that express either the human alpha 1 wild

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Krüger-Genge, Blocki, Franke, and Jung. "Vascular Endothelial Cell Biology: An Update." International Journal of Molecular Sciences 20, no. 18 (2019): 4411. http://dx.doi.org/10.3390/ijms20184411.

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The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood. The endothelium is not only a mere barrier between blood and tissues but also an endocrine organ. It actively controls the degree of vascular relaxation and constriction, and the extravasation of solutes, fluid, macromolecules and hormones, as well as that of platelets and blood cells. Through control of vascular tone, EC regulate the regional blood flow. They also direct inflammatory

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Voigts, Jakob, David H. Herman, and Tansu Celikel. "Tactile object localization by anticipatory whisker motion." Journal of Neurophysiology 113, no. 2 (2015): 620–32. http://dx.doi.org/10.1152/jn.00241.2014.

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Rodents use rhythmic protractions of their whiskers to locate objects in space. The amplitude of these protractions is reduced when whiskers contact objects, leading to a tendency of whiskers to only lightly touch the environment. While the impact of this process on the sensory input has been studied, little is known about how sensory input causes this change in the motor pattern. Here, using high-speed imaging of whisking in mice, we simultaneously measured whisker contacts and the resulting whisking motion. We found that mice precisely target their whisker protractions to the distance at whi

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Barbuti, Peter A. "A-Syn(ful) MAM: A Fresh Perspective on a Converging Domain in Parkinson’s Disease." International Journal of Molecular Sciences 25, no. 12 (2024): 6525. http://dx.doi.org/10.3390/ijms25126525.

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Parkinson’s disease (PD) is a disease of an unknown origin. Despite that, decades of research have provided considerable evidence that alpha-synuclein (αSyn) is central to the pathogenesis of disease. Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are functional domains formed at contact sites between the ER and mitochondria, with a well-established function of MAMs being the control of lipid homeostasis within the cell. Additionally, there are numerous proteins localized or enriched at MAMs that have regulatory roles in several different molecular signaling pathways requi

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Davis, Pierce Hunter, Qasim Qureshi, Zhengjia Wang, et al. "1008 Intraoperative Localization of a Novel 1024-Contact High-Density Electrode Array for Advanced Neural Decoding." Neurosurgery 71, Supplement_1 (2025): 131. https://doi.org/10.1227/neu.0000000000003360_1008.

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INTRODUCTION: The advancement of brain-computer interfaces (BCIs) is contingent on our capability to accurately decode neural signals. The recent development of novel high-density surface electrode arrays will facilitate the capture of more nuanced neural activations, enhancing our understanding of cortical functions. However, there is a need to develop precise localization protocols to better capture electrode contacts in relation to cortical anatomy. METHODS: We utilized a novel, 1024-contact high-density electrode array intraoperatively during hand gesture tasks. Electrode localization invo

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Yelnik, Jérôme, Philippe Damier, Sophie Demeret, et al. "Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas—magnetic resonance imaging coregistration method." Journal of Neurosurgery 99, no. 1 (2003): 89–99. http://dx.doi.org/10.3171/jns.2003.99.1.0089.

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Object. The aim of this study was to correlate the clinical improvement in patients with Parkinson disease (PD) treated using deep brain stimulation (DBS) of the subthalamic nucleus (STN) with the precise anatomical localization of stimulating electrodes. Methods. Localization was determined by superimposing figures from an anatomical atlas with postoperative magnetic resonance (MR) images obtained in each patient. This approach was validated by an analysis of experimental and clinical MR images of the electrode, and the development of a three-dimensional (3D) atlas—MR imaging coregistration m

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Bauer, Nicola, Ana-Violeta Fonseca, Daniel Freund, et al. "Cellular and Molecular Events Underlying the Interaction of Hematopoietic Stem and Progenitor Cells with Mesenchymal Stem Cells." Blood 106, no. 11 (2005): 2309. http://dx.doi.org/10.1182/blood.v106.11.2309.2309.

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Abstract Understanding the mechanisms underlying the reconstitution of the hematopoietic system after blood stem cell transplantation is of crucial importance for improving therapeutic modalities. In order to address these issues, we have recently established a novel co-culture system consisting of immuno-isolated human CD34+ hematopoietic stem and progenitor cells (HSPCs) growing on primary human mesenchymal stem cells (MSCs) as feeder layer in the presence of relevant cytokines. Here we have investigated i) the morphological modification of HSPCs induced by their interaction with MSCs; ii) t

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Kim, Min Jae, Rakesh Murugesan, Carley Gilman, Susan Sotardi, Eric Marsh, and Benjamin C. Kennedy. "1157 Co-Localization of Epileptiform Discharges With Preoperative Diffusion-Weighted Imaging Biomarkers in Pediatric Epilepsy." Neurosurgery 71, Supplement_1 (2025): 182. https://doi.org/10.1227/neu.0000000000003360_1157.

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INTRODUCTION: Minimally invasive procedures such as MRI-guided LiTT are increasingly being utilized in pediatric epilepsy patients; however, their clinical efficacy has been limited by challenges in precisely localizing epileptogenic tissues. A precise and accurate means to highlight epileptogenic tissues noninvasively will augment the utility of LiTT. Previous studies have suggested that an apparent diffusion coefficient (ADC) map may highlight microstructural abnormalities commonly seen in temporal lobe epilepsy and provide a prognosis for seizure freedom following LiTT. METHODS: Twelve pedi

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Danilko, Tatiana I., Ekaterina S. Hohrina, Olga K. Kiselevich, and Anna N. Yusubova. "Combined Tuberculosis of the Larynx and Lungs in a Tender-age Infant." Pediatric pharmacology 22, no. 2 (2025): 189–93. https://doi.org/10.15690/pf.v22i2.2870.

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Background. Tuberculosis in tender-age infants remains a serious and urgent problem due to the immaturity of the immune system, the lack of a specific clinical picture in the early stages of infection, difficulties in the differential diagnosis of X-ray signs of the disease and anatomical and physiological characteristics of the body. It is important that children from the group of close bacillary contact have a higher risk of developing the disease during the first years of life, especially in the absence of preventive treatment and dynamic monitoring.Case report. A case report of combined tu

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Khrestin A.V., Pavleino M. A., and Safonov M. S. "Changing the characteristics of contact spots when short-circuit currents flow through closed high-current electrical contacts." Technical Physics 68, no. 1 (2023): 137. http://dx.doi.org/10.21883/tp.2023.01.55448.233-22.

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Numerical simulation of heating of the vicinity of contact spots of closed copper high-current contacts by short-circuit currents of various shapes is carried out. The relationship between the parameters of thermal and mechanical fields when heated to temperatures exceeding the recrystallization temperature of the material is established. The dynamics of changes in the sizes of elastic and plastic deformations and their localization is shown. It is revealed in which cases the results of heating the contact surroundings may differ significantly with the flow of thermally equivalent currents. Ke

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Balkashin, O. P., and I. I. Kulik. "Relaxation kinetics for nonequilibrium quasiparticle excitations in antimony point contacts." Low Temperature Physics 21, no. 1 (1995): 32–37. https://doi.org/10.1063/10.0033754.

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The high-frequency point-contact spectroscopy technique is used for studying antimony contacts in the interval 3·103 − 8·1010 Hz. It is shown that the main contribution to the background signal in the PC spectrum is made by the processes of multiphonon relaxation of electrons, and not by the reabsorption of nonequilibrium phonons. The frequency of thermal relaxation of the point contact is determined from the frequency dispersion of the conductivity in the region of high voltages. The high-frequency results for contacts with inverse spectra are interpreted by using the model of spatial localiz

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Jansen, A. G. M., and P. Wyder. "Experimental overview of point-contact spectroscopy in metals." Soviet Journal of Low Temperature Physics 18, no. 5 (1992): 311. https://doi.org/10.1063/10.0033149.

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The smallness of metallic contacts (the contact size is smaller than the electron mean free path) permits spectroscopic studies to be made with respect to the well-defined excess energy eV of electrons by tuning the applied voltage V. Examples of point-contact spectroscopy will be given for the study of energy-dependent scattering of the electrons by quasiparticle excitations within a metal (phonons, magnons, paramagnetic impurities crystal field levels). The limitations of the point-contact technique will be discussed. The ballistic transport enables studies of other phenomena under the volta

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Хрестин, А. В., М. А. Павлейно та М. С. Сафонов. "Изменение характеристик контактных пятен при протекании токов короткого замыкания через замкнутые сильноточные электрические контакты". Журнал технической физики 93, № 1 (2023): 146. http://dx.doi.org/10.21883/jtf.2023.01.54075.233-22.

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Numerical simulation of heating of the vicinity of contact spots of closed copper high-current contacts by short-circuit currents of various shapes is carried out. The relationship between the parameters of thermal and mechanical fields when heated to temperatures exceeding the recrystallization temperature of the material is established. The dynamics of changes in the sizes of elastic and plastic deformations and their localization is shown. It is revealed in which cases the results of heating the contact surroundings may differ significantly with the flow of thermally equivalent currents.

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Sandig, Martin, Yong Rao, Chi-Hung Siu, and Vitauts I. Kalnins. "Integrity of the homophilic binding site is required for the preferential localization of NCAM in intercellular contacts." Biochemistry and Cell Biology 74, no. 3 (1996): 373–81. http://dx.doi.org/10.1139/o96-040.

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The neural cell adhesion molecule NCAM is a member of the immunoglobulin (Ig) superfamily. NCAM can undergo homophilic binding and heterophilic interactions with cell surface components and is often concentrated at sites of intercellular contact. To investigate the molecular basis of this biased surface distribution, we examined L cell transfectants expressing wild-type or mutant forms of chick NCAM-140 by laser scanning confocal microscopy. Mutant NCAMs that lacked Ig-like domains 1, 2, 4, or 5 were preferentially localized in contact regions. However, the relative concentration of these muta

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Casselmann, Lana, and Jonathan M. Fisher. "Localization for $K$-contact manifolds." Journal of Symplectic Geometry 17, no. 4 (2019): 1021–60. http://dx.doi.org/10.4310/jsg.2019.v17.n4.a3.

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Marcantonio, E. E., J. L. Guan, J. E. Trevithick, and R. O. Hynes. "Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis." Cell Regulation 1, no. 8 (1990): 597–604. http://dx.doi.org/10.1091/mbc.1.8.597.

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We describe here the expression of deletion mutants of the cytoplasmic domain of the avian integrin beta 1 subunit. These mutants, which contain termination codons at positions 767, 776, 791, and 800, were transfected into mouse 3T3 cells to determine which sequences were essential for localization of integrins into focal contact sites. In all cases, high-level expression of the truncated avian integrins was obtained. Heterodimers were formed between the exogenous truncated avian beta 1 subunits and endogenous mouse alpha subunits, and these heterodimers were efficiently exported to the cell s

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Huang, Lingqin, Sumin Pan, Xuliang Deng, and Wenwen Cui. "4H-SiC Ohmic contacts formation by MoS₂ layer intercalation: A first-principles study." Journal of Applied Physics 132, no. 24 (2022): 245702. http://dx.doi.org/10.1063/5.0122722.

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Due to the difficulty of forming a low Schottky barrier at the interface of a metal/SiC contact, preparing Ohmic contacts is still a key technical problem in developing SiC devices. In this paper, the effects of MoS2 intercalation on the interface properties of metal/SiC (Al, Ag, Ti, Au, and Mg) systems were investigated by first-principles calculation. The calculations show that all the metal/SiC contacts exhibit p-type Schottky contacts with strong Fermi level pinning (FLP) at the interfaces. After inserting a layer of MoS2, the Schottky barrier heights are significantly reduced. All the met

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Partridge, C. A., P. G. Phillips, M. J. Niedbala, and J. J. Jeffrey. "Localization and activation of type IV collagenase/gelatinase at endothelial focal contacts." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 5 (1997): L813—L822. http://dx.doi.org/10.1152/ajplung.1997.272.5.l813.

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The cell-surface localization and site of activation of type IV collagenases/gelatinases (matrix metalloproteinases, MMP) in bovine pulmonary microvascular endothelial (BPMVE) cells was examined. Sucrose density centrifugation of plasma membranes and immunofluorescent staining of whole cells indicated association of 72 kDa (MMP-2) and 96 kDa (MMP-9) type IV collagenase/gelatinases with the plasma membrane. Incubation of the BPMVE cells with rhodaminated MMP-9 demonstrated colocalization with beta 1-integrin, indicating incorporation into the focal contacts. The focal contacts were extracted wi

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Murley, Andrew, Reta D. Sarsam, Alexandre Toulmay, Justin Yamada, William A. Prinz, and Jodi Nunnari. "Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts." Journal of Cell Biology 209, no. 4 (2015): 539–48. http://dx.doi.org/10.1083/jcb.201502033.

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Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER–mitochondria and ER–vacuole contacts specified by an uncharacterized protein, Ylr072w. Ylr072w is a conserved protein with GRAM and VASt domains that selectively transports sterols and is thus termed Ltc1, for Lipid transfer at contact site 1. Ltc1 localized to ER–mitochondria and ER–vacuole contacts via the mitochondrial import receptors Tom70/71 and the vacuolar protein Vac8, respectively. At

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Fan, Lingzhi, Attila Sebe, Zalán Péterfi, et al. "Cell Contact–dependent Regulation of Epithelial–Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin Pathway." Molecular Biology of the Cell 18, no. 3 (2007): 1083–97. http://dx.doi.org/10.1091/mbc.e06-07-0602.

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Epithelial-mesenchymal-myofibroblast transition (EMT), a key feature in organ fibrosis, is regulated by the state of intercellular contacts. Our recent studies have shown that an initial injury of cell–cell junctions is a prerequisite for transforming growth factor-β1 (TGF-β1)-induced transdifferentiation of kidney tubular cells into α-smooth muscle actin (SMA)–expressing myofibroblasts. Here we analyzed the underlying contact-dependent mechanisms. Ca2+ removal–induced disruption of intercellular junctions provoked Rho/Rho kinase (ROK)-mediated myosin light chain (MLC) phosphorylation and Rho/

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Sandler, A. I., S. A. Lagutin, and E. A. Gudov. "Longitudinal contact localization in worm gears." Russian Engineering Research 34, no. 7 (2014): 480–86. http://dx.doi.org/10.3103/s1068798x14070119.

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Bean, Björn D. M., Samantha K. Dziurdzik, Kathleen L. Kolehmainen, et al. "Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites." Journal of Cell Biology 217, no. 10 (2018): 3593–607. http://dx.doi.org/10.1083/jcb.201804111.

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The regulated expansion of membrane contact sites, which mediate the nonvesicular exchange of lipids between organelles, requires the recruitment of additional contact site proteins. Yeast Vps13 dynamically localizes to membrane contacts that connect the ER, mitochondria, endosomes, and vacuoles and is recruited to the prospore membrane in meiosis, but its targeting mechanism is unclear. In this study, we identify the sorting nexin Ypt35 as a novel adaptor that recruits Vps13 to endosomal and vacuolar membranes. We characterize an interaction motif in the Ypt35 N terminus and identify related

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Steinfeldt, T., J. Graf, J. Schneider, et al. "Histological Consequences of Needle-Nerve Contact following Nerve Stimulation in a Pig Model." Anesthesiology Research and Practice 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/591851.

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Background. Nerve stimulation can facilitate correct needle placement in peripheral regional anesthesia. The aim of this study was to determine whether the high threshold current is associated with reduced nerve injury due to fewer needle-nerve contacts compared with low current.Methods. In anaesthetized pigs, thirty-two nerves of the brachial plexus underwent needle placement at low (0.2 mA) or high current (1.0 mA). The occurrence of needle-nerve contact was recorded. After 48 hours, the nerves were analyzed for occurrence of histological changes. Nerve injury was scored ranging from 0 (no i

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Boëx, Colette, Abdullah Al Awadhi, Rémi Tyrand та ін. "Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes". Bioengineering 10, № 8 (2023): 898. http://dx.doi.org/10.3390/bioengineering10080898.

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In deep brain stimulation (DBS) studies in patients with Parkinson’s disease, the Lead-DBS toolbox allows the reconstruction of the location of β-oscillations in the subthalamic nucleus (STN) using Vercise Cartesia directional electrodes (Boston Scientific). The objective was to compare these probabilistic locations with those of intraoperative monopolar β-oscillations computed from local field potentials (0.5–3 kHz) recorded by using shielded single wires and an extracranial shielded reference electrode. For each electrode contact, power spectral densities of the β-band (13–31 Hz) were compar

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Sánchez-Mateos, P., M. R. Campanero, M. A. Balboa, and F. Sánchez-Madrid. "Co-clustering of beta 1 integrins, cytoskeletal proteins, and tyrosine-phosphorylated substrates during integrin-mediated leukocyte aggregation." Journal of Immunology 151, no. 7 (1993): 3817–28. http://dx.doi.org/10.4049/jimmunol.151.7.3817.

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Abstract The involvement of the VLA-4 integrin in an alternative leukocyte homotypic adhesion mechanism that is LFA-1/ICAM-1 independent, has been previously reported. We describe here the localization of beta 1 and alpha 4 integrin subunits at sites of cell-cell contact, on both beta 1- and alpha 4-induced aggregates of B lymphoblastoid Ramos cells. Moreover, the distribution of different VLA-alpha subunits was also examined on beta 1-induced cell aggregates of alpha 2- and alpha 4-transfected K-562 cells. Both alpha 2 and alpha 4 integrin subunits were mainly localized at sites of intercellu

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Itskovich, I. F., I. O. Kulik, and R. I. Shekhter. "Localization and inelastic scattering of electrons in point-contact electric conductivity." Soviet Journal of Low Temperature Physics 13, no. 11 (1987): 659–65. https://doi.org/10.1063/10.0031821.

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Nonlinear electric conductivity of dirty point contacts between clean conductors is studied under the condition when the elastic scattering length is comparable with the de Broglie wavelength λF, of electrons. It is shown that the second derivative of the I–V characteristics has maxima whose positions coincide with the maxima of the electron–phonon interaction (EPI) function. However the sign of the point-contact (PC) spectrum is opposite to that in the ballistic or diffuse charge transport. Thus, the possibility of PC spectroscopy of EPI is established in highly disordered materials where the

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Myöhänen, H. T., R. W. Stephens, K. Hedman, et al. "Distribution and lateral mobility of the urokinase-receptor complex at the cell surface." Journal of Histochemistry & Cytochemistry 41, no. 9 (1993): 1291–301. http://dx.doi.org/10.1177/41.9.8394852.

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Pro-urokinase (pro-uPA) and activated uPA are confined to focal adhesions and cell-cell contacts. We studied the distribution of the uPA receptor (uPAR) on human fibroblasts (HES) and rhabdomyosarcoma (RD) cells by immunofluorescence and immunoelectron microscopy. Two monoclonal antibodies (MAb) utilized were against uPAR: MAb R4, which reacts with occupied and unoccupied uPAR, was concentrated at focal adhesions; MAb R3 reacting with unoccupied receptor stained cell surfaces diffusely. MAb R4 stained cell-cell contacts, tips of microspikes, and co-localized with vinculin. Of the matrix and in

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LaPlant, F., E. J. Hutchinson, and D. Ben-Amotz. "Raman Measurements of Localized Pressure Variations in Lubricants Above the Glass Transition Pressure." Journal of Tribology 119, no. 4 (1997): 817–22. http://dx.doi.org/10.1115/1.2833891.

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Spatial pressure variations in synthetic lubricants contained in a static high-pressure diamond anvil cell (DAC), as well as in a loaded model bearing contact device, have been measured using the frequency shift of the lubricant’s Raman vibrational modes. Long-lived pressure fluctuations of ±0.5 GPa, with a relaxation time of several days, are observed m the static high pressure systems at an average pressure of 2.5 GPa. Evidence for rapidly varying pressure fluctuations in a concentrated contact is inferred from the increase in lubricant Raman linewidths. These results raise questions about k

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