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Journal articles on the topic 'Continuous bioreactors'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Burton, Stephanie G. "Development of bioreactors for application of biocatalysts in biotransformations and bioremediation." Pure and Applied Chemistry 73, no. 1 (2001): 77–83. http://dx.doi.org/10.1351/pac200173010077.

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Biotransformation systems, whether used for environmentally benign biocatalysis of synthetic reactions, or bioremediation of pollutants, require suitable biocatalysts and suitable bioreactor systems with particular characteristics. Our research focuses on the bioconversion of organic compounds, many of which are industrial residues, such as phenols, poly-aromatic hydrocarbons, heterocyclic compounds, and polychlorinated biphenyls. The purpose of such biotransformations can be twofold: firstly, to remove them from effluents and convert them to less toxic forms, and secondly, to convert them int

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2

Cervantes, F. J., T. Duong-Dac, K. Roest, A. D. L. Akkermans, G. Lettinga, and J. A. Field. "Enrichment and immobilization of quinone-respiring bacteria in anaerobic granular sludge." Water Science and Technology 48, no. 6 (2003): 9–16. http://dx.doi.org/10.2166/wst.2003.0345.

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The capacity of an anaerobic granular sludge for serving as an immobilizing mechanism for quinone-respiring bacteria was evaluated. The inoculum was continuously fed with a basal medium containing the humic model compound, anthraquinone-2,6-disulfonate (AQDS), as a terminal electron acceptor. Complete reduction of AQDS was achieved by the granular sludge for a prolonged period in an anaerobic bioreactor provided with a mixture of volatile fatty acids as a substrate. Phylogenetic analysis revealed the enrichment and immobilization of AQDS-respiring bacteria appearing as dominant organisms in th

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3

Pathak, Nirenkumar, Van Huy Tran, Andrea Merenda, M. A. H. Johir, Sherub Phuntsho, and Hokyong Shon. "Removal of Organic Micro-Pollutants by Conventional Membrane Bioreactors and High-Retention Membrane Bioreactors." Applied Sciences 10, no. 8 (2020): 2969. http://dx.doi.org/10.3390/app10082969.

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The ubiquitous presence of organic micropollutants (OMPs) in the environment as a result of continuous discharge from wastewater treatment plants (WWTPs) into water matrices—even at trace concentrations (ng/L)—is of great concern, both in the public and environmental health domains. This fact essentially warrants developing and implementing energy-efficient, economical, sustainable and easy to handle technologies to meet stringent legislative requirements. Membrane-based processes—both stand-alone or integration of membrane processes—are an attractive option for the removal of OMPs because of

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4

Fitzpatrick, John J. "Insights from Mathematical Modelling into Energy Requirement and Process Design of Continuous and Batch Stirred Tank Aerobic Bioreactors." ChemEngineering 3, no. 3 (2019): 65. http://dx.doi.org/10.3390/chemengineering3030065.

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Bioreaction kinetics, oxygen transfer and energy modelling were applied to stirred tank aerobic bioreactors. This was done to investigate how key input design variables influence bioreactor size, feed and wasted substrate, and electrical energy requirements for aeration and cooling, and to compare batch and continuous modes of operation. Oxygen concentration in the liquid is a key input design variable, but its selection is challenging as it can result in design trade-offs. Reducing its value caused a decrease in electrical energy requirement, however this tended to increase the working volume

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5

da Costa, A. C., E. L. Lima, and T. L. M. Alves. "Start-up Strategy for Continuous Bioreactors." Brazilian Journal of Chemical Engineering 14, no. 2 (1997): 167–77. http://dx.doi.org/10.1590/s0104-66321997000200009.

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6

Golden, M. P., and B. E. Ydstie. "Nonlinear Adaptive Optimization of Continuous Bioreactors." IFAC Proceedings Volumes 20, no. 5 (1987): 351–56. http://dx.doi.org/10.1016/s1474-6670(17)55462-2.

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7

Syrou, L., I. Karafyllis, K. Stamatelatou, G. Lyberatos, and C. Kravaris. "Robust Global Stabilization of Continuous Bioreactors." IFAC Proceedings Volumes 37, no. 9 (2004): 995–1000. http://dx.doi.org/10.1016/s1474-6670(17)31938-9.

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8

Aguilar, R., J. González, M. Barrón, R. Martı́nez-Guerra, and R. Maya-Yescas. "Robust PI2 controller for continuous bioreactors." Process Biochemistry 36, no. 10 (2001): 1007–13. http://dx.doi.org/10.1016/s0032-9592(01)00133-9.

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9

Savoglidis, Georgios, and Costas Kravaris. "Constant-yield control of continuous bioreactors." Chemical Engineering Journal 228 (July 2013): 1234–47. http://dx.doi.org/10.1016/j.cej.2013.02.081.

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10

Jang, Ming-Feng, Yuh-Jong Chern, and Yi-Shyong Chou. "Robust adaptive controller for continuous bioreactors." Biochemical Engineering Journal 81 (December 2013): 136–45. http://dx.doi.org/10.1016/j.bej.2013.10.001.

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11

Radhakrishnan, T. K., S. Sundaram, and M. Chidambaram. "Non-linear control of continuous bioreactors." Bioprocess Engineering 20, no. 2 (1999): 173. http://dx.doi.org/10.1007/s004490050577.

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12

Yavari, Mohsen, Sirous Ebrahimi, Valeh Aghazadeh, and Mohammad Ghashghaee. "Kinetics of different bioreactor systems with Acidithiobacillus ferrooxidans for ferrous iron oxidation." Reaction Kinetics, Mechanisms and Catalysis 128, no. 2 (2019): 611–27. http://dx.doi.org/10.1007/s11144-019-01660-3.

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Abstract The relative performance of two biofilm-based airlift reactors using different kinds of packing materials and one fixed bed biofilm reactor with a homemade packing material of high specific area (~ 1000 m2/m3) was addressed. The bioreactors operated under ferrous iron loading rates in the range of 8–120 mol Fe(II)/m3 h. Acidithiobacillus ferrooxidans cells immobilized in the three bioreactors afforded the reactions for an extended period of 120 days of continuous operation at the dilution rates of 0.2, 0.4, 0.7, 1 and 1.2 h−1. The maximum ferrous iron oxidation rates achieved in this

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13

Lobos, J., C. Wisniewski, M. Heran, and A. Grasmick. "Continuous and sequencing membrane bioreactors applied to food industry effluent treatment." Water Science and Technology 56, no. 2 (2007): 71–77. http://dx.doi.org/10.2166/wst.2007.474.

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This work focuses on the performances of two immersed membrane bioreactors used for the treatment of easily biodegradable organic matter present in food industry effluents, for the purpose of water reuse. Two reactor functioning modes (continuous and sequencing) were compared in terms of organic carbon removal and of membrane permeability. For each working mode, pollutant removal was very high, treated water quality presented a low COD concentration (&lt;125 mg.L−1), no solids in suspension and low turbidity (&lt;0.5 NTU). The quality of the treated water (including germ removal) enabl

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14

Parada, Pilar, Pedro Morales, Roberto Collao, Roberto A. Bobadilla-Fazzini, and Ricardo Badilla. "Biomass Production and Inoculation of Industrial Bioleaching Processes." Advanced Materials Research 825 (October 2013): 296–300. http://dx.doi.org/10.4028/www.scientific.net/amr.825.296.

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Microbial activity inleaching processes accounts for 4% of today’s copper produced in the world. Factorsrelated with lesser overall metal recoveries, no recovery of precious metalsand molybdenum in comparison with conventional concentration/smelting &refining technologies and the high prices of metals inhibit the use of bioleachingat a larger scale. In order to increase bioleaching rates and overall metal recoveries,continuous inoculation of the ore with a leaching solution containing specific adaptedconsortium of microorganisms, allows an early expression of microbial activity,reducing 2-

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15

Weber, Christian, Sebastian Pohl, Ralf Pörtner, et al. "Cultivation and Differentiation of Encapsulated hMSC-TERT in a Disposable Small-Scale Syringe-Like Fixed Bed Reactor." Open Biomedical Engineering Journal 1, no. 1 (2007): 64–70. http://dx.doi.org/10.2174/1874120700701010064.

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The use of commercially available plastic syringes is introduced as disposable small-scale fixed bed bioreactors for the cultivation of implantable therapeutic cell systems on the basis of an alginate-encapsulated human mesenchymal stem cell line. The system introduced is fitted with a noninvasive oxygen sensor for the continuous monitoring of the cultivation process. Fixed bed bioreactors offer advantages in comparison to other systems due to their ease of automation and online monitoring capability during the cultivation process. These benefits combined with the advantage of single-use make

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16

Yang, Y. Y., and D. A. Linkenst. "Modelling of continuous bioreactors via neural networks." Transactions of the Institute of Measurement and Control 15, no. 4 (1993): 158–69. http://dx.doi.org/10.1177/014233129301500401.

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17

RAY, N. G., A. S. TUNG, E. G. HAYMAN, J. N. VOURNAKIS, and P. W. RUNSTADLER. "Continuous Cell Cultures in Fluidized-Bed Bioreactors." Annals of the New York Academy of Sciences 589, no. 1 Biochemical E (1990): 443–57. http://dx.doi.org/10.1111/j.1749-6632.1990.tb24263.x.

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18

G Whitford, William (Bill). "Single-use perfusion bioreactors support continuous biomanufacturing." Pharmaceutical Bioprocessing 3, no. 1 (2015): 75–93. http://dx.doi.org/10.4155/pbp.14.58.

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19

Aguilar-López, Ricardo, Edgar N. Tec-Caamal, and M. Isabel Neria-González. "Observer-Based Control for Uncertain Nonlinear Systems Applied to Continuous Biochemical Reactors." Mathematical Problems in Engineering 2020 (July 30, 2020): 1–8. http://dx.doi.org/10.1155/2020/6417860.

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The purpose of this paper is to present an observer-based control design with application to continuous bioreactors. For this purpose, phenomenological bioreactor models were represented by identified linear models plus unknown modelling error terms. Therefore, an uncertainty-based observer with a polynomial structure capable of estimating the unknown modelling error of the reactor representation is coupled to a linear input-output controller. The proposed methodology was evaluated in a sulphate reduction bioprocess and an acetone-butanol-ethanol (ABE) fermentation process for butanol (biofuel

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20

Sassi, Lisa, Omolola Ajayi, Sara Campinoti, et al. "A Perfusion Bioreactor for Longitudinal Monitoring of Bioengineered Liver Constructs." Nanomaterials 11, no. 2 (2021): 275. http://dx.doi.org/10.3390/nano11020275.

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In the field of in vitro liver disease models, decellularised organ scaffolds maintain the original biomechanical and biological properties of the extracellular matrix and are established supports for in vitro cell culture. However, tissue engineering approaches based on whole organ decellularized scaffolds are hampered by the scarcity of appropriate bioreactors that provide controlled 3D culture conditions. Novel specific bioreactors are needed to support long-term culture of bioengineered constructs allowing non-invasive longitudinal monitoring. Here, we designed and validated a specific bio

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21

Böhme, Andrea, Lars Radke, Felix Schütze, et al. "Miniaturized Flow-Through Bioreactor for Processing and Testing in Pharmacology." Materials Science Forum 879 (November 2016): 236–43. http://dx.doi.org/10.4028/www.scientific.net/msf.879.236.

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Conventional Bioreactor systems for cultivating cells in Life Science have been widely used for decades. An in vitro cell cultivation bioreactor should reliably and reproducibly mimic the in vivo microenvironment of the cultured cells. Normally, mammalian cell cultures are performed in conventional bioreactor devices such as culture flasks and culture-dishes. However, these tools have fundamental limitations due to being inappropriate for high throughput screening and consume a considerable amount of resources and time [1]. Therefore, there is a trend towards miniaturization, disposables and e

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22

Narayanan, C. M., and Aditi Pandey. "Studies on Biodiesel Synthesis Using Nanosilica Immobilised Lipase in Inverse Fluidized Bed Bioreactors." JOURNAL OF ADVANCES IN CHEMISTRY 15, no. 1 (2018): 6072–86. http://dx.doi.org/10.24297/jac.v15i1.7108.

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Biodiesel synthesis from neem oil and methyl acetate using lipase catalyst immobilised in nanosilica particles in a continuous inverse fluidised bed bioreactor of modified design has been analysed. The process has been simulated mathematically by developing a multiparameter software package and subsequently verified through pilot plant tests(experiments).The improved performance characteristics of the bioreactor of proposed design have been highlighted. Graphical data have been presented to illustrate the dependence of reactor performance on system/operating parameters such as substrate flow r

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23

Vits, Hugo, and Wei Shou Hu. "Fluctuations in continuous mammalian cell bioreactors with retention." Biotechnology Progress 8, no. 5 (1992): 397–403. http://dx.doi.org/10.1021/bp00017a004.

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24

Ajbar, A. "STUDY OF THE OPERABILITY OF NONIDEAL CONTINUOUS BIOREACTORS." Chemical Engineering Communications 198, no. 3 (2010): 385–415. http://dx.doi.org/10.1080/00986445.2010.512544.

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25

Dieulot, Jean-Yves. "A productivity signal feedback controller for continuous bioreactors." Journal of Process Control 22, no. 7 (2012): 1318–24. http://dx.doi.org/10.1016/j.jprocont.2012.06.002.

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26

Haque, Zahur U., and Zahid Mozaffar. "Casein hydrolysate. I. Continuous production using enzyme bioreactors." Food Hydrocolloids 5, no. 6 (1992): 549–57. http://dx.doi.org/10.1016/s0268-005x(09)80124-0.

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27

Bhugaloo-Vial, Parwin, Wlodzimierz Grajek, Xavier Dousset, and Patrick Boyaval. "Continuous bacteriocin production with high cell density bioreactors." Enzyme and Microbial Technology 21, no. 6 (1997): 450–57. http://dx.doi.org/10.1016/s0141-0229(97)00026-4.

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28

Zhao, Ying, and Sigurd Skogestad. "Comparison of Various Control Configurations for Continuous Bioreactors." Industrial & Engineering Chemistry Research 36, no. 3 (1997): 697–705. http://dx.doi.org/10.1021/ie960123l.

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29

Toda, Kiyoshi. "Theoretical and methodological studies of continuous microbial bioreactors." Journal of General and Applied Microbiology 49, no. 4 (2003): 219–33. http://dx.doi.org/10.2323/jgam.49.219.

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30

LaPara, Timothy M., Allan Konopka, Cindy H. Nakatsu, and James E. Alleman. "Thermophilic Aerobic Wastewater Treatment in Continuous-Flow Bioreactors." Journal of Environmental Engineering 126, no. 8 (2000): 739–44. http://dx.doi.org/10.1061/(asce)0733-9372(2000)126:8(739).

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31

WEI, DANIEL, SATISH J. PARULEKAR, and WILLIAM A. WEIGAND. "Multivariable Control of Continuous and Fed-Batch Bioreactors." Annals of the New York Academy of Sciences 589, no. 1 Biochemical E (1990): 508–28. http://dx.doi.org/10.1111/j.1749-6632.1990.tb24267.x.

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32

Kanai, T., J. Ichikawa, H. Yoshikawa, and Y. Kawase. "Dynamic modeling and simulation of continuous airlift bioreactors." Bioprocess Engineering 23, no. 3 (2000): 0213–20. http://dx.doi.org/10.1007/s004499900154.

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33

Grzywacz, Robert. "Continuous mathematical models of airlift bioreactors: Families, affinity, diversity and modelling for single-substrate kinetics." Chemical and Process Engineering 33, no. 2 (2012): 291–309. http://dx.doi.org/10.2478/v10176-012-0027-9.

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Continuous mathematical models of airlift bioreactors: Families, affinity, diversity and modelling for single-substrate kinetics This paper presents a method of describing an airlift bioreactor, in which biodegradation of a carbonaceous substrate described by single-substrate kinetics takes place. Eight mathematical models based on the assumption of liquid plug flow and axial dispersion flow through the riser and the downcomer in the reactor were proposed. Additionally, the impact of degassing zone with assumed complete mixing on the obtained results was analyzed. Calculations were performed f

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34

Mel’nick, V., L. Rhuzinska, and O. Vorobiova. "ANALYSIS OF EXISTING BIOREACTORS WITH IMMOBILIZED MICROORGANISMS." Municipal economy of cities 3, no. 149 (2019): 51–57. http://dx.doi.org/10.33042/2522-1809-2019-3-149-51-57.

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This review article describes the current state of the industry of immobilized cells and the development of bioreactors with immobilized cells and carrier materials for immobilization. On the basis of literature analysis, a classification of constructions of bioreactors with immobilized cells is proposed, depending on the location of cellular aggregates: suspended particles, fixed particles and moving surfaces used with immobilized cells. The modern development of biotechnological production requires new approaches to the implementation of biosynthesis processes. The performance of bioreactors

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35

Warith, Mostafa A., and Graham J. Takata. "Effect of Aeration on Fresh and Aged Municipal Solid Waste in a Simulated Landfill Bioreactor." Water Quality Research Journal 39, no. 3 (2004): 223–29. http://dx.doi.org/10.2166/wqrj.2004.031.

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Abstract Municipal solid waste (MSW) is slow to stabilize under conventional anaerobic landfill conditions, demanding long-term monitoring and pollution control. Provision of aerobic conditions offers several advantages including accelerated leachate stabilization, increased landfill airspace recovery and a reduction in greenhouse gas emissions. Air injection was applied over 130 days to bench-scale bioreactors containing fresh and aged MSW representative of newly constructed and pre-existing landfill conditions. In the fresh MSW simulation bioreactors, aeration reduced the average time to sta

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36

Koller, MR, SG Emerson, and BO Palsson. "Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures." Blood 82, no. 2 (1993): 378–84. http://dx.doi.org/10.1182/blood.v82.2.378.378.

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Abstract There is a growing consensus that clinical practice in the areas of bone marrow (BM) transplantation and gene therapy will rely on the ex vivo expansion of hematopoietic cells. We report here on the development of continuously perfused culture systems (bioreactor systems) that expand human stem and progenitor cells from BM mononuclear cell (MNC) populations obtained without cell enrichment. In three separate experiments, 10 bioreactors were each inoculated with 3 x 10(7) BM MNC from patients undergoing marrow harvest for autologous transplantation. At various times thereafter (between

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37

Koller, MR, SG Emerson, and BO Palsson. "Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures." Blood 82, no. 2 (1993): 378–84. http://dx.doi.org/10.1182/blood.v82.2.378.bloodjournal822378.

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There is a growing consensus that clinical practice in the areas of bone marrow (BM) transplantation and gene therapy will rely on the ex vivo expansion of hematopoietic cells. We report here on the development of continuously perfused culture systems (bioreactor systems) that expand human stem and progenitor cells from BM mononuclear cell (MNC) populations obtained without cell enrichment. In three separate experiments, 10 bioreactors were each inoculated with 3 x 10(7) BM MNC from patients undergoing marrow harvest for autologous transplantation. At various times thereafter (between days 6 a

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38

Garza-García, Lucía D., Erika García-López, Sergio Camacho-León, et al. "Continuous flow micro-bioreactors for the production of biopharmaceuticals: the effect of geometry, surface texture, and flow rate." Lab Chip 14, no. 7 (2014): 1320–29. http://dx.doi.org/10.1039/c3lc51301g.

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39

SZYMAŃSKA, GRAŻYNA, BOGUSŁAW SOBIERAJSKI, and ALEKSANDER CHMIEL. "Immobilized Cells of Recombinant Escherichia coli Strain for Continuous Production of L-aspartic Acid." Polish Journal of Microbiology 60, no. 2 (2011): 105–12. http://dx.doi.org/10.33073/pjm-2011-014.

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For L-aspartic acid biosynthesis, high production cells of Escherichia coli mutant B-715 and P1 were immobilized in chitosan gel using a technique developed in our laboratory. The immobilization process reduced initial activity of the intact cells, however, the biocatalyst produced was very stabile for long-term use in multi-repeated batch or continuous processes. Temperature influence on the conversion of ammonium fumarate to L-aspartic acid was investigated. In long-term experiments, over 603 hours, the temperature 40 degrees C was found to be the best for both biocatalyst stability and high

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40

Chorukova, Elena, Ivan Simeonov, and Lyudmila Kabaivanova. "Volumes Ratio Optimization in a Cascade Anaerobic Digestion System Producing Hydrogen and Methane." Ecological Chemistry and Engineering S 28, no. 2 (2021): 183–200. http://dx.doi.org/10.2478/eces-2021-0014.

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Abstract As focus of humans has turned to renewable energy, the role of anaerobic digestion has started to become economically viable. Reducing the volume of agro-wastes for the generation of gaseous and liquid fractions with energy carriers and valuable products is an enormous challenge. A two-stage anaerobic digestion process consisting of hydrogenic stage followed by methanogenic stage was studied in a laboratory scale. Five simple nonlinear models of this continuous cascade process were studied in order to determine the optimal ratio of working volumes of bioreactors, in view of maximising

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41

Gabriel Yabo, Agustín, Jean-Baptiste Caillau, and Jean-Luc Gouzé. "Optimal bacterial resource allocation: metabolite production in continuous bioreactors." Mathematical Biosciences and Engineering 17, no. 6 (2020): 7074–100. http://dx.doi.org/10.3934/mbe.2020364.

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42

Phelps, T. J., J. J. Niedzielski, R. M. Schram, S. E. Herbes, and D. C. White. "Biodegradation of Trichloroethylene in Continuous-Recycle Expanded-Bed Bioreactors." Applied and Environmental Microbiology 56, no. 6 (1990): 1702–9. http://dx.doi.org/10.1128/aem.56.6.1702-1709.1990.

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43

Mantzaris, Nikos V., and Prodromos Daoutidis. "Cell population balance modeling and control in continuous bioreactors." Journal of Process Control 14, no. 7 (2004): 775–84. http://dx.doi.org/10.1016/j.jprocont.2003.12.001.

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44

Reinecke, T., P. Biechele, M. Sobocinski, et al. "Continuous noninvasive monitoring of cell growth in disposable bioreactors." Sensors and Actuators B: Chemical 251 (November 2017): 1009–17. http://dx.doi.org/10.1016/j.snb.2017.05.111.

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45

Kan, Eunsung, and Marc A. Deshusses. "Continuous operation of foamed emulsion bioreactors treating toluene vapors." Biotechnology and Bioengineering 92, no. 3 (2005): 364–71. http://dx.doi.org/10.1002/bit.20619.

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46

Guilherme, Ederson Paulo Xavier, Jocilane Pereira de Oliveira, Lorendane Millena de Carvalho, et al. "Synthesis of supermacroporous cryogel for bioreactors continuous starch hydrolysis." ELECTROPHORESIS 38, no. 22-23 (2017): 2940–46. http://dx.doi.org/10.1002/elps.201700208.

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47

Zhang, T., M. Guay, and D. Dochain. "Adaptive extremum seeking control of continuous stirred-tank bioreactors." AIChE Journal 49, no. 1 (2003): 113–23. http://dx.doi.org/10.1002/aic.690490111.

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48

Zhang, T., M. Guay, and D. Dochain. "ADAPTIVE EXTREMUM SEEKING CONTROL OF CONTINUOUS STIRRED TANK BIOREACTORS." IFAC Proceedings Volumes 35, no. 1 (2002): 449–54. http://dx.doi.org/10.3182/20020721-6-es-1901.01384.

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49

Peris, Edgar, Obinna Okafor, Evelina Kulcinskaja, et al. "Tuneable 3D printed bioreactors for transaminations under continuous-flow." Green Chemistry 19, no. 22 (2017): 5345–49. http://dx.doi.org/10.1039/c7gc02421e.

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50

Schaum, A., J. Alvarez, and T. Lopez-Arenas. "Saturated PI control of continuous bioreactors with Haldane kinetics." Chemical Engineering Science 68, no. 1 (2012): 520–29. http://dx.doi.org/10.1016/j.ces.2011.10.006.

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