Relevant bibliographies by topics / Continuous Stirred Tank Bioreactors

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Continuous Stirred Tank Bioreactors'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Continuous Stirred Tank Bioreactors"

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Zhang, T., M. Guay, and D. Dochain. "Adaptive extremum seeking control of continuous stirred-tank bioreactors." AIChE Journal 49, no. 1 (January 2003): 113–23. http://dx.doi.org/10.1002/aic.690490111.

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Zhang, T., M. Guay, and D. Dochain. "ADAPTIVE EXTREMUM SEEKING CONTROL OF CONTINUOUS STIRRED TANK BIOREACTORS." IFAC Proceedings Volumes 35, no. 1 (2002): 449–54. http://dx.doi.org/10.3182/20020721-6-es-1901.01384.

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Guay, M., D. Dochain, and M. Perrier. "Adaptive Extremum Seeking Control of Continuous Stirred Tank Bioreactors 1." IFAC Proceedings Volumes 37, no. 1 (January 2004): 311–16. http://dx.doi.org/10.1016/s1474-6670(17)38750-5.

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Fitzpatrick, John J. "Insights from Mathematical Modelling into Energy Requirement and Process Design of Continuous and Batch Stirred Tank Aerobic Bioreactors." ChemEngineering 3, no. 3 (July 13, 2019): 65. http://dx.doi.org/10.3390/chemengineering3030065.

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Bioreaction kinetics, oxygen transfer and energy modelling were applied to stirred tank aerobic bioreactors. This was done to investigate how key input design variables influence bioreactor size, feed and wasted substrate, and electrical energy requirements for aeration and cooling, and to compare batch and continuous modes of operation. Oxygen concentration in the liquid is a key input design variable, but its selection is challenging as it can result in design trade-offs. Reducing its value caused a decrease in electrical energy requirement, however this tended to increase the working volume of the bioreactor. The minimum or near-to-minimum total energy requirement for oxygen transfer occurred when operating at the onset of flooding throughout the bioreaction time. For typical KS values, continuous mode of operation required a much smaller bioreactor volume, due to higher operating cell concentration, and this is a major advantage of continuous over batch.
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Tsao, Jia-Huey, and Wen-Teng Wu. "Global control of a continuous stirred tank bioreactor." Chemical Engineering Journal and the Biochemical Engineering Journal 56, no. 1 (December 1994): B69—B74. http://dx.doi.org/10.1016/0923-0467(94)87034-9.

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Murray, Michael A., and Vijay T. John. "Generalized optimal flow rate policy for continuous stirred tank bioreactors with deactivating catalysts." Biotechnology and Bioengineering 30, no. 9 (December 20, 1987): 1084–87. http://dx.doi.org/10.1002/bit.260300913.

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Guay, M., D. Dochain, and M. Perrier. "Adaptive extremum seeking control of continuous stirred tank bioreactors with unknown growth kinetics." Automatica 40, no. 5 (May 2004): 881–88. http://dx.doi.org/10.1016/j.automatica.2004.01.002.

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Khongsay, Naulchan, Lakkana Laopaiboon, and Pattana Laopaiboon. "Continuous ethanol production from sweet sorghum stem juice using stirred tank and tubular bioreactors." Journal of Biotechnology 136 (October 2008): S446. http://dx.doi.org/10.1016/j.jbiotec.2008.07.1036.

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Aguilar-López, R., and I. Neria-González. "Controlling continuous bioreactor via nonlinear feedback: modelling and simulations approach." Bulletin of the Polish Academy of Sciences Technical Sciences 64, no. 1 (March 1, 2016): 235–41. http://dx.doi.org/10.1515/bpasts-2016-0025.

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Abstract The aim of this work is to present a class of nonlinear controller with an exponential-type feedback in order to regulate the sulfate mass concentration via the input flow in a continuous stirred tank bioreactor of an anaerobic sulfate-reducing process. The corresponding kinetic terms in the bioreactor’s modeling are modeled by unstructured modeling approach, which was experimentally corroborated. A sketch of proof of the closed-loop stability of the considered system is done under the framework of Lyapunov theory. Numerical experiments are conducted to show the performance of the proposed methodology in comparison with a well-tuned sigmoid controller.
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Pinheiro, I. O., M. B. De Souza, and C. E. Lopes. "The dynamic behaviour of aerated continuous flow stirred tank bioreactor." Mathematical and Computer Modelling 39, no. 4-5 (February 2004): 541–66. http://dx.doi.org/10.1016/s0895-7177(04)90525-0.

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Dissertations / Theses on the topic "Continuous Stirred Tank Bioreactors"

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Lutsinge, Tshilidzi Bridget. "Biosurfactant enhanced biodegradation of high molecular weight polycyclic aromatic hydrocarbons in a two-stage continuous stirred tank bioreactors and biofilm tank." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/66214.

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Polycyclic aromatic hydrocarbons (PAHs) do not dissolve easily in water, due to their hydrophobic properties. PAHs are unavailable to most aromatic compound degrading organisms, due to these properties. In this study, a biosurfactant producing culture enhancing dissolution of PAHs was isolated, to make them bioavailable. The culture was introduced to the system to improve the dissolution of PAHs and degrade the PAHs thereafter. The aim of the study was to use a strategy with a biofilm process, subsequent to a continuous stirred tank bio-reactors (CSTRs) to successfully remove PAHs from water, with microorganisms that can degrade these pollutants. The open system could easily be controlled and set to optimum conditions, stimulating the growth of PAH degraders. The feed rate and influent concentration can be controlled and the system can easily be cleaned. Biodegradation was achieved, using optimum conditions obtained from the conducted batch studies in a CSTR process ensuring a feasible biodegradation process. Two cultures, Pseudomonas aeruginosa and microbial consortia, were used during the biosurfactant production and PAHs degradation preliminary batch studies. The biosurfactants produced, were identified as Lipopeptides and degradation results indicated great degradation of fluoranthene and triphenylene with a mixed culture consortium present in the system. 90.1% of fluoranthene and 79.6% of triphenylene was degraded after 22 d of incubation in the batch system. Degradation of fluoranthene was studied using biosurfactants and microbial consortium in a three-stage continuous flow system. Reactor 2A fluoranthene influent (60.89%) was degraded, 70.02% of Reactor 2B fluoranthene influent was degraded and 77.17% of biofilm tank fluoranthene influent was degraded. Kinetic studies were conducted, using a Monod model to describe the substrates degradation for batch systems. The highest degradation rate for fluoranthene was determined to be 0.29 h-1 and for triphenylene was 0.13 h-1 with half saturation values of 991.84 mg/L and 451 mg/L respectively, indicating that fluoranthene was degraded faster than triphenylene, when incubated for 22 d. The study demonstrated that biosurfactant production and biodegradation of fluoranthene can be achieved in an open CSTR system, as much as it can be done in a batch system. The biological remediation of PAHs in wastewater plants can be introduced and applied for wastewaters rich, with PAHs.
Dissertation (MSc)--University of Pretoria, 2017.
Chemical Engineering
MSc
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Strandberg, Per Erik. "Mathematical models of bacteria population growth in bioreactors: formulation, phase space pictures, optimisation and control." Thesis, Linköping University, Department of Mathematics, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2337.

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There are many types of bioreactors used for producing bacteria populations in commercial, medical and research applications.

This report presents a systematic discussion of some of the most important models corresponding to the well known reproduction kinetics such as the Michaelis-Menten kinetics, competitive substrate inhibition and competitive product inhibition. We propose a modification of a known model, analyze it in the same manner as known models and discuss the most popular types of bioreactors and ways of controlling them.

This work summarises much of the known results and may serve as an aid in attempts to design new models.

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Samer, Charles J. "Polymer-stabilized miniemulsion polymerization in a continuous stirred-tank reactor." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/11142.

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Lee, Hsueh-Chi. "Emulsion polymerization in a seed-fed continuous stirred-tank reactor." Diss., Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/11860.

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Mushonga, Sylvester Paul. "pH control using two continuous stirred tank reactors in series." Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1595785.

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The control of pH is one of the most difficult chemical control schemes in industry. Often, large tanks are used to control pH. The pH in these large tanks frequently overshoots the desired pH set-point and usually takes a long time to reach the desired set-point. In this work, a conceptual pH control process was developed and tested by using two small continuous stirred tank reactors (CSTRs). In this two-step system, the bulk of the neutralization is carried out in the first reactor and then fine-tuned in the second reactor. The conceptual neutralization model was built by analyzing the chemistry behind pH. Because pH is a nonlinear function of hydrogen ion concentration (pH= -log [H+]), the hydrogen ion concentration was chosen as the process measured variable. The slope (Gain) was calculated from a titration curve obtained from a polynomial derived from neutralization chemistry and a practical titration. The process dynamics were then fitted into the classic proportional, integral, and differential (PID) controller using the Internal Model Control (IMC) tuning method. The robust tuning parameters produced by the IMC method were able to bring the pH in the first CSTR to the desired set-point. In addition, disturbances from vibrations produced by the pump and magnetic stirrer, slight variations in reactant concentration, and pH probe lags were easily eliminated. Most importantly, pH in the second CSTR settled on the desired neutral set-point of pH 7.0 after brief oscillations. The process was repeatable when the reactors where scaled up one hundred times using synthetic waste water. Autotune variation results produced similar process dynamics to those produced by calculating the slope from the titration curve.

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Regestein, Lars [Verfasser]. "Design and application of calorimeters for monitoring biological processes in stirred tank bioreactors / Lars Regestein." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1031109536/34.

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Adkins, Carol Leslie Jones Seinfeld John H. Flagan Richard C. "Use of a continuous stirred tank reactor for the study of aqueous aerosol chemistry." Diss., Pasadena, Calif. : California Institute of Technology, 1988. http://resolver.caltech.edu/CaltechTHESIS:12042009-080025691.

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Thesis (Ph. D.)--California Institute of Technology, 1988. UM #88-03,381.
Advisor names found in the Acknowledgments pages of the thesis. Title from home page. Viewed 02/19/2010. Includes bibliographical references.
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Loubière, Céline. "Characterization and impact of the hydrodynamics on the performance of umbilical-cord derived stem cells culture in stirred tank bioreactors." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0220/document.

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Les cellules souches mésenchymateuses (CSM) interviennent de plus en plus dans le domaine de la médecine régénérative, notamment pour traiter des maladies aujourd’hui difficilement curables avec les moyens actuels. Deux verrous scientifiques limitent pourtant leur utilisation et leur commercialisation. D’une part, de grandes quantités de cellules sont nécessaires pour répondre à la forte demande médicale. D’autre part, les cellules étant elles-mêmes le médicament final, délivré chez le patient, leur qualité doit être préservée (phénotype souche, capacité de différenciation). La mise en culture de ces cellules, sur des microporteurs, en bioréacteur agité, semble répondre à ces enjeux. Cependant, une connaissance plus précise de l’impact, sur la réponse physiologique des cellules, des technologies utilisées et de l’hydrodynamique générée est nécessaire pour améliorer les lois d’extrapolation des bioréacteurs de culture de CSM. Dans ce contexte, des travaux ont été mis en œuvre pour étudier l’influence du mode d’agitation (orbital ou mécanique) sur l’attachement, l’expansion et le détachement de CSM issues de la gelée de Wharton (GW-CSM) de cordons ombilicaux, sur des microporteurs de différentes compositions. Pour contribuer à la quantification de l’expansion cellulaire, une méthode de comptage automatique in situ a été développée pour estimer le nombre de cellules par microporteur, ainsi que leur répartition, sans avoir à procéder à leur détachement. Des microporteurs commerciaux ont ensuite pu être comparés à des microporteurs synthétisés dans un laboratoire partenaire, en termes d’attachement et expansion cellulaire, ainsi que de facilité de détachement. En parallèle de ces travaux, l’impact de la conception du mobile d’agitation, en bioréacteur mécaniquement agité, sur la mise en suspension de microporteurs a été analysé. A l’issue de cette étude, une analyse dimensionnelle et des simulations CFD ont été mises en place et deux modèles reliant la fréquence minimale de juste mise en suspension (Njs) avec la géométrie du mobile d’agitation (forme, taille, position dans la cuve) et les propriétés matérielles des particules et de la phase liquide ont été proposés. Une stratégie d’optimisation des paramètres géométriques d’un mobile en minibioréacteur, dédié à la culture de CSM sur microporteurs, a été mise en place, à partir de paramètres caractérisant les contraintes hydromécaniques perçues par la phase solide, judicieusement choisis et intégrés lors des simulations CFD. Selon un plan d’expérience, et les résultats extraits des simulations, des surfaces de réponse ont été construites et une optimisation multi-objective a été réalisée afin de déterminer la géométrie minimisant les contraintes perçues par les particules, et donc par les cellules adhérées. Des cultures de GW-CSM en minibioréacteurs équipés de différents mobiles ont finalement été validées, avec une comparaison préliminaire de l’impact de ces géométries sur l’expansion cellulaire
Mesenchymal stem cells (MSC) are becoming increasingly involved in the regenerative medicine field, particularly to treat diseases that are not effectively curable with the current therapies. Two scientific barriers are nevertheless responsible for MSC use and commercialization limitations. On one side, large amounts of cells are needed to reach the high cell dose requirements. On the other side, cells being the final product themselves, directly injected into the patient, their quality have to be controlled (stem cell phenotype, differentiation capability). MSC cultivation on microcarriers in a stirred bioreactor seems to meet these challenges. However, a precise knowledge about the impact of the technologies and the hydrodynamics generated, on the physiological cell response, is necessary to improve the scale-up of MSC cultures in bioreactors. In this context, present work is dedicated to the study of the impact of the agitation mode (orbital or mechanical) on the cell attachment, expansion and detachment on various microcarrier types, in the case of MSC derived from the Wharton’s jelly (WJ-MSC) of umbilical cords. To quantify more precisely cell distribution and expansion on microcarriers, an automatic and in situ counting method was developed, which need no detachment step. This allowed the identification of commercial microcarriers suitable for WJ-MSC cultures, which were then compared to home-made microcarriers, synthesized by a partner laboratory, in terms of cell attachment and expansion, and detachment efficiency. In parallel to these works, the impact of the impeller design on the microcarrier suspension in stirred tank bioreactors was investigated. Based on a dimensional analysis and CFD simulations, it resulted in the establishment of two models relating the minimal agitation rate to ensure all particle suspension (Njs) with the impeller geometrical characteristics (design, size, off-bottom clearance) and the material properties of both the solid and the liquid phases. CFD models validation allowed then to develop a strategy to optimize the geometrical configuration of an impeller, dedicated to MSC cultures on microcarriers in a minibioreactor. Parameters characterizing the hydromechanical stress encountered by the solid phase were wisely chosen and integrated into CFD simulations. Based on a design of experiments, and the hydrodynamics data recovered from simulations, response surfaces were built and a multiobjective optimization was achieved in order to determine the geometry minimizing the particle stress, and also by adhered cells. WJ-MSC cultures in minibioreactors equipped with impellers displaying various geometries were finally validated, with a preliminary comparison of the impact of these geometries on the cell expansion
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Amoabediny, Ghassem. "A new method to quantify the CO2 sensitivity of micro-organisms in shaken bioreactors and scale up to stirred tank fermentors." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982158823.

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Brito, Bernardo Nascimbeni de. "Effect of the sulfide, pH and temperature on anammox activity in a continuous flow stirred-tank reactor." Universidade Federal de Viçosa, 2015. http://www.locus.ufv.br/handle/123456789/7373.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Um promissor processo biológico para a remoção de elevadas concentrações de nitrogênio de águas residuárias vem sendo estudado nos últimos 20 anos. O processo possibilita uma redução substancial nos requisitos de aeração, fontes de carbono e baixa produção de biomassa. Durante 9 meses, um reator continuo de mistura completa com nitrificação parcial e processo anammox ocorrendo simultaneamente em único estágio foi operado com medições e análises regulares. Foram avaliados o desempenho do reator e sua capacidade de recuperação após exposição a curto-prazo da adição de sulfeto, pH em condições ácidas e temperaturas abaixo dos valores ótimos. O reator demonstrou ser sensível a pequenas variações de pH. Observou-se que o reator operando com valores de pH inferiores a 6,71 ± 0,01, apresentou perda na eficiência de remoção de amônia. As concentrações de 0,1 e 0,25 mg S L -1 de sulfeto testados apresentaram efeito inibitório. A faixa de temperatura de 36 – 25°C testada, não comprometeu a performance do reator.
A new biological process that removes high concentrations of nitrogen from residual waters has been studied for the last twenty years. Such process allows for a substantial reduction on aeration and carbon sources requirements while also producing low levels of biomass. For nine months, a continuum reactor composed of a complete mixture with partial nitrification and the anammox process occurring simultaneously was operated with regular mediation and analysis. An evaluation was conducted on short-term effects of sulfide's addition, pH in acidic conditions and the temperature below optimum values of reactor's functioning, as well as its capacity to recover after exposed. The reactor showed sensitivity to small variations on pH. Losses in ammonia removal efficiency were observed when the reactor operated at pH values lower than 6.71 ± 0.01. The tested sulfide concentrations, i.e. 0.1 and 0.25 mg S L -1 , have caused inhibitory effect. The temperature range of 36 - 25 o C did not compromised the reactor's performance.
Título em inglês do resumo, difere da ficha catalográfica, folha de aprovação e termo de autorização anexado ao formulário 7, enviado por e-mail, pelo departamento em 21/03/2016.
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Books on the topic "Continuous Stirred Tank Bioreactors"

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Tyagi, Rajesh. Control of pH in a continuous stirred tank reactor (CSTR). Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.

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Henderson, Kelley. Oxygen mass transfer and shear sensitivity studies during cultivation of Nicotiana tabacum var. Wisconsin 38 in a stirred-tank bioreactor. 1991.

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Ho, Chung-Han. Shear sensitivity and oxygen mass transfer studies during cultivation of tobacco cells in a stirred-tank bioreactor of impeller speeds of 100 to 325 rpm. 1994.

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Book chapters on the topic "Continuous Stirred Tank Bioreactors"

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Barbieri, Giuseppe. "Continuous Stirred Tank Membrane Reactor (CST-MR)." In Encyclopedia of Membranes, 448–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_152.

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Barbieri, Giuseppe. "Continuous Stirred Tank Membrane Reactor (CST-MR)." In Encyclopedia of Membranes, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_152-1.

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Manstein, Felix, Caroline Halloin, and Robert Zweigerdt. "Human Pluripotent Stem Cell Expansion in Stirred Tank Bioreactors." In Methods in Molecular Biology, 79–91. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9477-9_7.

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Papavasiliou, Georgia, and Fouad Teymour. "Nonlinear Dynamics in Continuous Stirred Tank Reactor Polymerization." In Nonlinear Dynamics in Polymeric Systems, 309–23. Washington, DC: American Chemical Society, 2003. http://dx.doi.org/10.1021/bk-2004-0869.ch024.

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Reuss, Matthias, Sven Schmalzriedt, and Marc Jenne. "Application of Computational Fluiddynamics (CFD) to Modeling Stirred Tank Bioreactors." In Bioreaction Engineering, 207–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59735-0_8.

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Ranjan, Ankita, and Sarbani Chakraborty. "Phase Portrait Analysis of Continuous Stirred Tank Reactor (CSTR)." In Nanoelectronics, Circuits and Communication Systems, 177–92. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7486-3_18.

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Wang, Huaqing, Daniel Kehoe, Julie Murrell, and Donghui Jing. "Structured Methodology for Process Development in Scalable Stirred Tank Bioreactors Platforms." In Bioprocessing for Cell Based Therapies, 35–64. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118743362.ch2.

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Simão, Daniel, Francisca Arez, Ana P. Terasso, Catarina Pinto, Marcos F. Q. Sousa, Catarina Brito, and Paula M. Alves. "Perfusion Stirred-Tank Bioreactors for 3D Differentiation of Human Neural Stem Cells." In Methods in Molecular Biology, 129–42. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/7651_2016_333.

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Nguyen, Hoai-Nam. "A Benchmark Problem: The Non-isothermal Continuous Stirred Tank Reactor." In Lecture Notes in Control and Information Sciences, 181–87. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02827-9_8.

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Hong, Man, and Shao Cheng. "Hammerstein-Wiener Model Predictive Control of Continuous Stirred Tank Reactor." In Lecture Notes in Electrical Engineering, 235–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21697-8_30.

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Conference papers on the topic "Continuous Stirred Tank Bioreactors"

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Marin, Constantin, Dan Selisteanu, Dan Popescu, and Monica Roman. "Adaptive optimal control of a Continuous Stirred Tank Bioreactor." In 2015 19th International Conference on System Theory, Control and Computing (ICSTCC). IEEE, 2015. http://dx.doi.org/10.1109/icstcc.2015.7321268.

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Daaou, Bachir, and Denis Dochain. "High order sliding mode observer based extremum seeking controller for a continuous stirred tank bioreactor." In 2015 3rd International Conference on Control, Engineering & Information Technology (CEIT). IEEE, 2015. http://dx.doi.org/10.1109/ceit.2015.7233018.

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Kapadia, A., N. Nath, T. C. Burg, and D. M. Dawson. "Lyapunov-based continuous-stirred tank bioreactor control to maximize biomass production using the haldane and monod specific growth models." In 2010 American Control Conference (ACC 2010). IEEE, 2010. http://dx.doi.org/10.1109/acc.2010.5531387.

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Kadic, Enes, and Theodore J. Heindel. "Mixing Considerations in Stirred Tank Bioreactors When Using Fluid Property Altering Microorganisms." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30366.

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Stirred tank reactors are one of the standard reactors in the chemical industry and have been widely implemented for biological applications. They are used with viscous liquids, slurries, very low gas flow rates, and large liquid volumes. Stirred tank bioreactors are popular because a well-mixed state, required or preferred for numerous biological processes, is usually achieved in such situations; however, many production processes using microorganisms tend to experience fluid property alterations, which significantly impact mixing, operational parameters, and process results. The most troubling issues occur when a fluid gradually undergoes a viscosity change and/or slowly exhibits non-Newtonian behavior due to microorganism growth since these will alter the flow conditions and possibly limit the conversion rate or production scale. This paper provides an overview of the relevant mixing issues in stirred tank bioreactors when using a range of fluid viscosities, surface tensions, and/or non-Newtonian fluids.
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Vojtesek, J., and P. Dostal. "Simulation Analyses Of Continuous Stirred Tank Reactor." In 22nd Conference on Modelling and Simulation. ECMS, 2008. http://dx.doi.org/10.7148/2008-0506.

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Liovic, Petar, Ilija D. Šutalo, Laurence Meagher, and George O. Lovrecz. "Computations of Flow Environments in Medium-Scale Stirred-Tank Bioreactors for Stem Cell Expansion." In ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting collocated with the ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/fedsm2014-21967.

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The flow in a New Brunswick Scientific (NBS (now Eppendorf)) 5 L stirred-tank bioreactor (STR) partially filled with 2.2 L of water and agitated at 60 rpm using a pitched-blade impeller is studied in this work, to determine the suitability of the configuration for expanding stem cell lines. Computational Fluid Dynamics (CFD) model development and testing in this work has found Large Eddy Simulation (LES) to be essential for model fidelity and for capturing spatiotemporal stress fluctuations. Stresses were at levels similar to or even higher than those known to damage stem cells or modulate their cellular function to favour differentiation instead of phenotype maintenance. The results raise questions as to the appropriateness of such STRs for stem cell expansion, and motivate better experimental studies to properly quantify the spatiotemporal variability in fluid shear stresses and its effect on stem cell expansion and stem cell fate.
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Kim, Kee Jeong, and Kyu Yong Choi. "Estimation and Control of Continuous Stirred Tank Polymerization Reactors." In 1990 American Control Conference. IEEE, 1990. http://dx.doi.org/10.23919/acc.1990.4790798.

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Dostal, Petr, Vladimir Bobal, and Jiri Vojtesek. "Simulation Of Cascade Control Of A Continuous Stirred Tank Reactor." In 29th Conference on Modelling and Simulation. ECMS, 2015. http://dx.doi.org/10.7148/2015-0266.

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Dostal, Petr, Jiri Vojtesek, and Vladimir Bobal. "Simulation Of Adaptive Control Of A Continuous Stirred Tank Reactor." In 23rd European Conference on Modelling and Simulation. ECMS, 2009. http://dx.doi.org/10.7148/2009-0525-0530.

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Singh, Anurag, Shekhar Yadav, and Navdeep Singh. "Enhancement of Continuous-Stirred Tank Reactor System Using Jaya Algorithm." In 2018 2nd International Conference on Electronics, Materials Engineering & Nano-Technology (IEMENTech). IEEE, 2018. http://dx.doi.org/10.1109/iementech.2018.8465157.

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Reports on the topic "Continuous Stirred Tank Bioreactors"

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Lee, D. D., and J. L. Collins. Continuous-flow stirred-tank reactor 20-L demonstration test: Final report. Office of Scientific and Technical Information (OSTI), February 2000. http://dx.doi.org/10.2172/752984.

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Peterson, R. A. The demonstration of continuous stirred tank reactor operations with high level waste. Office of Scientific and Technical Information (OSTI), July 2000. http://dx.doi.org/10.2172/758796.

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3

Lee, D. D. Evaluation of the Small-Tank Tetraphenylborate Process Using a Bench-Scale, 20-L Continuous Stirred Tank Reactor System at Oak Ridge National Laboratory: Results of Test 5. Office of Scientific and Technical Information (OSTI), August 2001. http://dx.doi.org/10.2172/814370.

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