Academic literature on the topic 'Contraction and neurotransmitter'

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Journal articles on the topic "Contraction and neurotransmitter"

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Hayashi, Tatsuya, Michael F. Hirshman, Scott D. Dufresne, and Laurie J. Goodyear. "Skeletal muscle contractile activity in vitro stimulates mitogen-activated protein kinase signaling." American Journal of Physiology-Cell Physiology 277, no. 4 (1999): C701—C707. http://dx.doi.org/10.1152/ajpcell.1999.277.4.c701.

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Physical exercise is a potent stimulator of mitogen-activated protein (MAP) kinase signaling. To determine if this activation is secondary to systemic responses to exercise or due to muscle contractile activity per se, an isolated muscle preparation was developed. Contractile activity in vitro significantly increased p44MAPK and p42MAPK phosphorylation by 2.9- and 2.4-fold, respectively. Contraction-stimulated MAP kinase phosphorylation was not decreased in the presence ofd-tubocurarine or calphostin C, suggesting that neither neurotransmitter release nor diacylglycerol-sensitive protein kinas
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Wu, David M., Hajime Kawamura, Kenji Sakagami, Masato Kobayashi, and Donald G. Puro. "Cholinergic regulation of pericyte-containing retinal microvessels." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 6 (2003): H2083—H2090. http://dx.doi.org/10.1152/ajpheart.01007.2002.

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The aim of this study was to test the hypothesis that the neurotransmitter acetylcholine regulates the function of pericyte-containing retinal microvessels. A vasoactive role for acetylcholine is suggested by the presence of muscarinic receptors on pericytes, which are abluminally positioned contractile cells that may regulate capillary perfusion. However, little is known about the response of retinal microvessels to this neurotransmitter. Here we assessed the effects of cholinergic agonists on microvessels freshly isolated from the adult rat retina. Ionic currents were monitored via perforate
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Ardasheva, Raina, Veselin Popov, Viktor Yotov, et al. "Accelerated Electron Ionization-Induced Changes in the Myenteric Plexus of the Rat Stomach." International Journal of Molecular Sciences 25, no. 12 (2024): 6807. http://dx.doi.org/10.3390/ijms25126807.

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The influence of accelerated electrons on neuronal structures is scarcely explored compared to gamma and X-rays. This study aims to investigate the effects of accelerated electron radiation on some pivotal neurotransmitter circuits (cholinergic and serotonergic) of rats’ myenteric plexus. Male Wistar rats were irradiated with an electron beam (9 MeV, 5 Gy) generated by a multimodality linear accelerator. The contractile activity of isolated smooth muscle samples from the gastric corpus was measured. Furthermore, an electrical stimulation (200 μs, 20 Hz, 50 s, 60 V) was performed on the samples
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Wiens, B. L., and P. H. Brownell. "Neurotransmitter regulation of the heart in the nudibranch Archidoris montereyensis." Journal of Neurophysiology 74, no. 4 (1995): 1639–51. http://dx.doi.org/10.1152/jn.1995.74.4.1639.

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1. The heart of the nudibranch mollusc Archidoris montereyensis is uniquely responsive to regulation by identifiable cardiac motor neurons. The neurotransmitters mediating the strong excitatory and inhibitory actions of the neurons are unknown. 2. In this study we developed an infused, in vitro preparation of the Archidoris heart to determine which of several cardioactive transmitters described in mollusks could affect changes in the rate, amplitude, or tonus of cardiac contractions. Several neurotransmitters we tested increased the rate and amplitude of heart contractions, including serotonin
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Grider, John R., and Lea E. Langdon. "Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 6 (2003): G1139—G1146. http://dx.doi.org/10.1152/ajpgi.00082.2003.

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The physiological role of neuropeptide Y (NPY) and of specific NPY receptors in regulating the intestinal peristaltic reflex was examined in three-compartment flat-sheet preparations of rat colon. Graded muscle stretch or mucosal stimulation applied to the central compartment inhibited NPY release in the orad compartment where ascending contraction was measured. NPY and the Y1-receptor agonist [Leu31, Pro34]NPY inhibited, whereas the selective Y1-receptor antagonist BIBP 3226 augmented ascending contraction and substance P (SP) release in the orad compartment induced by muscle stretch or mucos
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Sugawa, Makoto, Tohru Koide, Shigetaka Naitoh, Michiaki Takato, Tohru Matsui, and Takao Asano. "Phorbol 12,13-Diacetate-Induced Contraction of the Canine Basilar Artery: Role of Protein Kinase C." Journal of Cerebral Blood Flow & Metabolism 11, no. 1 (1991): 135–42. http://dx.doi.org/10.1038/jcbfm.1991.16.

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The pharmacological and biochemical mechanisms of contractile responses to the protein kinase C (PKC) activator phorbol-12, 13-diacetate (PDA) were investigated in canine basilar arteries, In the normal medium, PDA elicited a strong, dose-related, and slow-developing sustained contraction, Among the constrictors examined, including serotonin, prostaglandin F2α and endothelin, only PDA yielded contractions in a 2 Ca2+ -free medium, In both media, the PDA-induced contractions were virtually inhibited by either staurosporine, H-7, or quinacrine, while neither neurotransmitter blockades nor R24571
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Perez, Jose F., and Michael J. Sanderson. "The Frequency of Calcium Oscillations Induced by 5-HT, ACH, and KCl Determine the Contraction of Smooth Muscle Cells of Intrapulmonary Bronchioles." Journal of General Physiology 125, no. 6 (2005): 535–53. http://dx.doi.org/10.1085/jgp.200409216.

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Increased resistance of airways or blood vessels within the lung is associated with asthma or pulmonary hypertension and results from contraction of smooth muscle cells (SMCs). To study the mechanisms regulating these contractions, we developed a mouse lung slice preparation containing bronchioles and arterioles and used phase-contrast and confocal microscopy to correlate the contractile responses with changes in [Ca2+]i of the SMCs. The airways are the focus of this study. The agonists, 5-hydroxytrypamine (5-HT) and acetylcholine (ACH) induced a concentration-dependent contraction of the airw
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Day, T. A., A. G. Maule, C. Shaw, et al. "Platyhelminth FMRFamide-related peptides (FaRPs) contract Schistosoma mansoni (Trematoda: Digenea) muscle fibres in vitro." Parasitology 109, no. 4 (1994): 455–59. http://dx.doi.org/10.1017/s0031182000080707.

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SUMMARYMolluscan FMRFamide and two recently discovered platyhelminth FMRFamide-related peptides (FaRPs), GNFFRFamide from the cestode Moniezia expansa and RYIRFamide from the terrestrial turbellarian Artioposthia triangulata, cause dose-dependent contractions of individual muscle fibres from Schistosoma mansoni in vitro. The most potent FaRP tested was the turbellarian peptide RYIRFamide, which produced a concentration-dependent effect between 10−9 and 10−7 M. FMRFamide and GNFFRFamide were less potent, inducing contractions between 10−8–10−6 M and 10−7–10−5 M respectively. The contractile eff
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Wang, Guo-Du, Xi-Yu Wang, Sumei Liu та ін. "β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum". American Journal of Physiology-Gastrointestinal and Liver Physiology 308, № 11 (2015): G955—G963. http://dx.doi.org/10.1152/ajpgi.00430.2014.

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Intracellular microelectrodes were used to record neurogenic inhibitory junction potentials in the intestinal circular muscle coat. Electrical field stimulation was used to stimulate intramural neurons and evoke contraction of the smooth musculature. Exposure to β-nicotinamide adenine dinucleotide (β-NAD) did not alter smooth muscle membrane potential in guinea pig colon or human jejunum. ATP, ADP, β-NAD, and adenosine, as well as the purinergic P2Y1 receptor antagonists MRS 2179 and MRS 2500 and the adenosine A1 receptor agonist 2-chloro- N6-cyclopentyladenosine, each suppressed inhibitory ju
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Kim, Chi Dae, Raj K. Goyal, and Hiroshi Mashimo. "Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter." American Journal of Physiology-Gastrointestinal and Liver Physiology 277, no. 2 (1999): G280—G284. http://dx.doi.org/10.1152/ajpgi.1999.277.2.g280.

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To identify the enzymatic source of nitric oxide (NO) in the lower esophageal sphincter (LES), studies were performed in wild-type and genetically engineered endothelial nitric oxide synthase [eNOS(−)] and neuronal NOS [nNOS(−)] mice. Under nonadrenergic noncholinergic (NANC) conditions, LES ring preparations developed spontaneous tone in all animals. In the wild-type mice, electrical field stimulation produced frequency-dependent intrastimulus relaxation and a poststimulus rebound contraction. NOS inhibitor N ω-nitro-l-arginine methyl ester (100 μM) abolished intrastimulus relaxation and rebo
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Dissertations / Theses on the topic "Contraction and neurotransmitter"

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Masters, Jonathan Grenville. "Sources of calcium involved in detrusor smooth muscle contraction." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312030.

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Howarth, Christopher John. "Pharmacology of the isolated gut of the caterpillar Spodoptera frugiperda : a study of the contractile effects of proctolin, helicokinins and 5-hydroxytryptamine." Thesis, University of the West of England, Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342671.

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Piekarz, Andrew D. "Increased Resurgent Sodium Currents (INaR) in Inherited and Acquired Disorders of Excitability." Thesis, 2012. http://hdl.handle.net/1805/2886.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Voltage-gated sodium channels (VGSCs) are dynamic membrane spanning proteins which mediate the rapid influx of Na+ during the upstroke of the action potential (AP). In addition to the large inward Na+ currents responsible for the upstroke of the AP, some VGSC isoforms produce smaller, subthreshold Na+ currents, which can influence the excitable properties of neurons. An example of such a subthreshold current is resurgent Na+ current (INaR). These unusual currents are active during repolarization of the membrane potential, where the
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Books on the topic "Contraction and neurotransmitter"

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T, Kappagoda C., Kaufman Marc P, and Symposium on Control of the Cardiovascular and Respiratory Systems in Health and Disease (1994 : University of California, Davis), eds. Control of the cardiovascular and respiratory systems in health and disease. Plenum Press, 1995.

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(Editor), C. Tissa Kappagoda, and Marc P. Kaufman (Editor), eds. Control of the Cardiovascular and Respiratory Systems in Health and Disease (Advances in Experimental Medicine and Biology). Springer, 1996.

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Higashida, Haruhiro, and Tohru Yoshioka. Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction: In Memory of Professor Sh (Annals of the New York Academy of Sciences). New York Academy of Sciences, 1994.

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Higashida, Haruhiro, Tohru Yoshioka, and Katsuhiko Mikoshiba. Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission and Muscle Contraction: In Memory of Professor (Annals of the New York Academy of Sciences). New York Academy of Sciences, 1993.

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Book chapters on the topic "Contraction and neurotransmitter"

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Batu, Ozlem. "Oxytocin." In Brain Biochemistry and Its Disease. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359371.2.

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Oxytocin is a peptide hormone secreted from the posterior pituitary. Its best-known function is to increase milk secretion in breastfeeding women. It can be used pharmacologically to induce uterine contractions and sustain labour. However, it is thought that its contribution to birth is minimal at physiologically normal blood levels. This hormone, which acts as a neurotransmitter in the central nervous system, is also effective in regulating blood circulation. It balances the mood and is important in regulating behaviour in different emotional states. It helps to experience positive emotions.
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Treves, S., and F. Zorzato. "Introduction." In Guidebook to Protein Toxins and Their Use in Cell Biology. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599555.003.0076.

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Abstract Ca2+ release from intracellular stores plays an important role in the regulation of numerous cellular functions ranging from muscle contraction to cell division and neurotransmitter release. The intracellular Ca2+ stores of excitable and nonexcitable cells utilize one or two of the intracellular Ca2+ channels to release Ca2+ upon cell stimulation, namely the ryanodine and the inositol 1,4,5-trisphosphate receptors (Berridge 1993).The mammalian ryanodine receptor (RYR) is a large tetrameric oligomer made up of four subunits of 560 kDa, which migrate as a single protein in 5D5- polyacry
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Emmett, Stevan R., Nicola Hill, and Federico Dajas-Bailador. "Gastroenterology." In Clinical Pharmacology for Prescribing. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780199694938.003.0014.

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Nausea and vomiting can be defined, respectively, as the urge to or the actual act of expelling undigested food from the stomach. It is thought to be an evolutionary defence mechanism to protect against toxic insult (drugs or mi­crobes) and over- eating, while it can also be triggered during pregnancy, or by unpleasant sights or smells. In some instances, it may be the symptom of a more severe underlying pathology. Severity of nausea and vomiting varies considerably between individuals exposed to the same stimulus and symptoms can be highly detrimental to patient quality of life affecting not
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Baptista, Mariana, Jurandyr Pimentel Neto, Paula Oliveira Camargo, Adriano Polican Ciena, and Lara Caetano Rocha-Braga. "Neuromuscular junction: Morphoquantitative methods of investigation." In Princípios da Biologia Integrada: Conceitos e Aplicações. Editora Científica Digital, 2025. https://doi.org/10.37885/250619555.

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The neuromuscular junction (NMJ) is the area located between the axon terminal and the muscle fiber. It comprises both pre-and postsynaptic structures where the electrical signal is converted into a chemical signal, leading to neurotransmitter release and subsequent muscle contraction. The NMJ undergoes changes due to stimuli such as physical exercise, aging, and nerve or muscle injury, making its analysis crucial. This chapter aims to provide a comprehensive bibliographic review and highlight the key methodologies for morphoquantitative analysis of the postsynaptic receptors at the NMJ. The e
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Dell’italia, Lours J., and Jeffrey L. Ardell. "Sympathetic Nervous System in the Evolution of Heart Failure." In Basic and Clinical Neurocardiology. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195141290.003.0012.

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Abstract In response to a variety of stresses, including exercise, traumatic injury, and blood loss, the need for increased cardiac output is met by a commensurate increase in adrenergic drive. As a result, norepinephrine (NE), the primary neurotransmitter of the adrenergic system, is released from sympathetic nerve endings in the heart. Myocardial adrenergic receptor signaling path­ ways are activated, resulting in increases in heart rate, rate of electrical conduction, and force of contraction. Early sympathetic neuronal activation in cardiac injury and/or hemodynamic overload increases vent
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Koch, Christof. "Ionic Channels." In Biophysics of Computation. Oxford University Press, 1998. http://dx.doi.org/10.1093/oso/9780195104912.003.0014.

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In the previous chapters, we studied the spread of the membrane potential in passive or active neuronal structures and the interaction among two or more synaptic inputs. We have yet to give a full account of ionic channels, the elementary units underlying all of this dizzying variety of electrical signaling both within and between neurons. Ionic channels are individual proteins anchored within the bilipid membrane of neurons, glia, or other cells, and can be thought of as water-filled macromolecular pores that are permeable to particular ions. They can be exquisitely voltage sensitive, as the
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Kuiper, M. A., G. J. van Kamp, and E. Ch Wolters. "CCK: its role in dopamine-related disorders." In Multiple Cholecystokinin Receptors in the CNS. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198577560.003.0037.

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Abstract The peptide now recognized as CCK was originally identified as the compound responsible for causing contraction of the gall bladder and stimulation of pancreatic enzyme secretion (Jorpes and Mutt 1966). However, CCK is also synthesized in the CNS (Dockray et al. 1977). The brain peptide differs from the gastric peptide and consists primarily of the biologically active sulphated carboxyl-terminal octapeptide (CCK-8S). It is distributed throughout the whole brain with the exception of the cerebellum. In the cerebral cortex and hippocampus CCK exceeds the level of any other neuropeptide
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B.Levitan, Irwin, and Leonard K. Kaczmarek. "Neurotransmitters and Neurohormones." In The Neuron. Oxford University PressNew York, NY, 2001. http://dx.doi.org/10.1093/oso/9780195145236.003.0010.

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Abstract We have seen in the previous two chapters that a neuron is in large part an elaborate and intricately regulated machine for the secretion of a variety of chemicals. Why do cells go to all this trouble? Although direct electrical connections between nerve cells also play an essential role (see Chapter 8), it is chemical signaling that mediates much of the intercellular communication among nerve cells within the central nervous system. In addition, the transfer of information into the nervous system from sensory organs and the output from the nervous sys tem in the form of muscular cont
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Andrew, David, and Scott Samuels. "Cholinergic Neurotransmission and Toxicity – Neonicotinoids and Spinosad." In Neurotransmitters and Toxicology. Royal Society of Chemistry, 2024. http://dx.doi.org/10.1039/9781839165795-00049.

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Neonicotinoid insecticides are chemically similar to nicotine, exerting their activity by acting as agonists of the nicotinic acetylcholine receptor (nAChR). nAChRs are polypeptides consisting of five subunits arranged around a central non-selective cation channel and are located at the neuromuscular junction, in the autonomic ganglia and in the brain. Activation of the receptor following neonicotinoid binding allows the transit of ions, including sodium, potassium and calcium. Differences in the receptor subunit composition underlie the basis for the selective activity of the neonicotinoids o
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Cooper, Jack R., Floyd E. Bloom, and Robert H. Roth. "Serotonin (5-Hydroxytryptamine), Histamine, and Adenosine." In The Biochemical Basis of Neuropharmacology. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195140071.003.0010.

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Abstract Of all the neurotransmitters discussed in this book, serotonin remains historically the most intimately involved with neuropsychopharmacology. From the mid-nineteenth century, scientists had been aware that a substance found in serum caused powerful contraction of smooth muscle organs, but over 100 years passed before scientists at the Cleveland Clinic succeeded in isolating this substance as a possible cause of high blood pressure.
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Conference papers on the topic "Contraction and neurotransmitter"

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Tsukimata, Márcio Yutaka, Bianca Lumi Inomata da Silva, and Jennison Alves Guimarães. "Açaí: potential anticonvulsant agent." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.064.

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Background: Convulsion is an involuntary contraction of skeletal muscles. When considering vulnerable populations exposed to the mentioned pathophysiological situation, it is recognized that many of them will not have access to the indicated pharmacological treatment. Therefore, the ingestion of açai, Euterpe oleracea (EO) attenuates the problem, acting as an anticonvulsant. Objectives: evaluate the EO as an anticonvulsant agent. Design and setting: It is a bibliographic research and the data collection was done from the PubMed and Scielo databases. Methods: The descriptor used was “Euterpe ol
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