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Dissertations / Theses on the topic 'Contribution in Medicine'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Smyth, Clifford. "The contribution of Feldenkrais Method to mind-body medicine." Thesis, Saybrook Graduate School and Research Center, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1536829.

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<p> The Feldenkrais Method generates a range of healthful or salutogenic outcomes, yet its contribution to the field of mind-body medicine (MBM) remains largely unexamined. The Feldenkrais Method is a form of somatic education offering both practices and theoretical perspectives for an integrated mind-body approach. Research shows that the Feldenkrais Method produces outcomes on a range of functional, psychophysical, and psychosocial measures. This thesis argues that the Feldenkrais Method is an awareness practice of value for mind-body and integrative approaches to health. </p><p> Possible

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2

Mclaughlin, Kevin James. "The contribution of analytic information processing to diagnostic performance in medicine." Rotterdam : Rotterdam : Erasmus Universiteit ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10198.

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3

Mitchell, Wayne William Alfred. "Contribution of troponin-I to the regulation of cardiac muscle." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1505/.

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Troponin-I (TnI) is one of the three components that makes up the troponin complex, which along with tropomyosin regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become phosphorylated by protein kinase A upon \(\beta\)-adrenergic stimulation. However, the function of the N-terminus of cTnI remains unclear. Questions also remain about the function of the C-terminal region of cTnI, although its importance has been demonstrated by mutagenesis and deletion studies. With the use of \(^1\)H nuc

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4

Zweigenthal, Virginia E. M. "The contribution of public health medicine specialists to South Africa's health system." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/22843.

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Background: While South Africa's Constitution, health legislation and policies value public health (PH) approaches, Public Health Medicine (PHM) specialists are largely invisible in the health services. Despite this, many undertake specialist training. The reasons for this mismatch, for doctors' motivations for this training, and the career paths of PHM specialists are not known – nor is it known if their practice is aligned with the intentions of trainers, policy makers and employers. Postulates for their invisibility are that they are not required, are unknown, are interchangeable, not 'serv

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5

Greenwood, Diane E. "A contribution towards understanding ways of working with older adults." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/63950/.

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This thesis comprises a literature review, an empirical paper and a reflective paper. The systematic literature review involved critical assessment of eleven randomised controlled trials in which cognitive-behavioural therapy (CBT) for anxiety or depression was modified for older adults. The aim was to identify older adult-specific modifications as well as effectiveness in symptom reduction. Most commonly, modifications aimed to support understanding and homework completion, but few were age-specific. Studies comparing modified and standard CBT are lacking. Modified CBT may be more effective t

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6

Droogan, Aidan Gerard. "The contribution of T lymphocytes and adhesion molecules to the pathogenesis of multiple sclerosis." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318769.

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7

Beasley, Charles Richard William. "The contribution of bronchoconstrictor prostanoids to the immediate allergen-induced airways response in asthma." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316306.

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8

Cacou, Crina. "The contribution of mechanical forces to the healing of wounds in the human skin." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602272.

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The effect of mechanical forces in the healing of human wounds has been investigated. The study examined the effect of forces acting perpendicular to the plane of skin and parallel to it. The closure force of 17 surgical wounds made in favourable and unfavourable directions was measured and a relationship between the mechanical force acting across a wound and the final scar width became apparent. A technique to alter the local forces acting on a wound during healing was established. The results from eleven patients are presented and improved wound healing and prevention of hypertrophy was obta

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9

Busque, Stephan. "Contribution of donor T-lymphocytes to graft immunogenicity." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23871.

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We used genetically T-lymphopenic rats as donors to probe the contribution of T-lymphocytes to graft immunogenicity. Graft survival (GS) of lymphopenic donors was significantly increased as compared to normal donors (median (M) = 17 days vs M = 7d, n = 10). To confirm this observation, we reconstituted 7 lymphopenic rats before organ retrieval with $10 sp7-10 sp8$ purified T-lymphocytes. GS was significantly shorter than with lymphopenic donors (M = 7d, n = 7 vs M = 17d, n = 10). Conversely, we treated 6 normal donors with R7.3 (mouse anti-rat TCR $ alpha/ beta$) monoclonal antibody (mab). GS

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10

Le, Brenne Arielle. "Contribution of bone marrow derived cells to four mouse models of gastrointestinal tumourigenesis." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8986.

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Introduction: Houghton and colleagues (2004) demonstrated bone marrow derived cells (BMDCs) to be the origin of epithelial cells in pre-invasive and malignant gastric tumours in Helicobacter felis infected mice. However, this has yet to be replicated in any other experimental scenario. Methods: To clarify the significance of Houghton’s observation we examined four mouse models of gastrointestinal tumourigenesis: the Tff1-/- mouse model of inflammatory gastric adenocarcinoma, the ApcMin/+ and Apc1322T mouse models of familial adenomatous polyposis, and the Il10-/- mouse model of colitis-associa

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11

Menon, Vinal. "The contribution of visceral fat to positive insulin signaling in Ames dwarf mice." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5818.

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Ames dwarf (df/df) mice are homozygous for a spontaneous mutation in the prop1 gene due to which there is no development of anterior pituitary cells – somatotrophs, lactotrophs and thyrotrophs, leading to a deficiency of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). They tend to become obese as they age, but still live longer and healthier lives compared to their wild-type littermates, being very insulin sensitive, showing no signs of diabetes and cancer. These mutant mice also have high circulating levels of anti-inflammatory and anti-diabetic adiponectin. Plasma levels of this

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12

Evans, Nicola. "Exploring the contribution of safe uncertainty in facilitating change." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/62079/.

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Background This PhD study was an examination of the mechanism adopted by a change agent during an organisational change in healthcare. The context for the study was the secondary analysis of action research in a Child and Adolescent Mental Health Service (CAMHS) that had developed practice at an organisational level to address the excessive waiting list impacting upon that service. Aims and Objectives The research question addressed in the thesis was How does a change agent facilitate organisational change in a health setting? The objectives of this study were to i. explore the current literat

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13

Yuhas, Phillip Thomas. "Isolation of ipRGC Contribution to the Human Pupillary Light Response." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397469110.

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14

Lees, John. "A contribution to developing the counselling and psychotheraphy profession : a reflexive action research study." Thesis, University of Greenwich, 2005. http://gala.gre.ac.uk/8083/.

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This study has a manifest and a latent aspect. The manifest aspect tells a story about some key developments within the counselling and psychotherapy professions in recent years. 1 begin by looking at three phenomena which have been referred to as Schoolism, the research-practice gap and the hierarchy of evidence. I argue that it is important to address these phenomena as the profession moves towards statutory registration under the aegis of the Health Professions Council. I also argue that, in order to achieve this and develop a cohesive profession, traditional research methodologies which th

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15

Whittle, Ian Roger. "The contribution of secondary mediators to the etiology and pathophysiology of brain oedema : experimental studies using an infusion model." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/24421.

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Moffatt, Christine J. "A study to investigate the relative contribution of clinical and psychosocial factors in healing of patients with leg ulceration." Thesis, St George's, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252108.

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17

Seabrook, Hannah. "A contribution to supporting and understanding the end stage renal failure experience." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/49348/.

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There are 30,000 people in the UK who are on dialysis or that have received a transplant for chronic kidney failure (Stein & Wilde, 2006). Those with a diagnosis of End Stage Renal Failure (ESRF) face a gruelling treatment regimen with dialysis providing only 5% of the function two healthy kidneys would supply (Stein & Wilde, 2006). Patients face many changes to their lifestyle and these are often difficult to manage. The treatment necessary for such a condition is complex and includes restrictions to diet and fluid intake as well ingestion of medication and attending dialysis. Many patients s

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Karim, Sumera. "The contribution of vascular adhesion protein-1 to glucose and lipid homeostasis in the liver." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4556/.

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NAFLD is characterized by simple steatosis, which can progress to chronic inflammation and fibrosis. Vascular Adhesion Protein-1 (VAP-1) is an adhesion molecule with semicarbazide- sensitive amine oxidase (SSAO) activity, which is also expressed as a soluble protein in serum (sVAP-1) and elevated in inflammatory liver diseases such as NAFLD. VAP-1 has been shown to modulate glucose and lipid uptake in muscle and adipose tissue and thus we investigated whether it may contribute to glucose and lipid homeostasis in human liver tissue. Recreating the multicellular liver environment using an ex-viv

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Conigliaro, Paola. "Dissecting the contribution of B cells in an experimental model of rheumatoid arthritis." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/6209/.

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Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease characterised by extensive synovitis resulting in cartilage and bone erosions. Both the innate and adaptive immune pathways contribute to the initiation and the maintenance of the disease. Understanding the role of these pathways is central to develop new therapeutics. We have developed a murine model of RA where ovalbumin (OVA) specific Th1 cells induced a breach of self-tolerance and a transient monoarthritis. This thesis aimed firstly to create a model of chronic autoimmune polyarthritis and then to investigate the contribut

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Dunbar, Graeme Leslie. "The contribution of diabetes mellitus to lower extremity amputations in four public sector hospitals in Cape Town for 2009 and 2010." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/12315.

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Includes bibliographical references.<br>Diabetes is the most common non-communicable disease worldwide and contributes to substantial morbidity and mortality. The prevalence of diabetes is increasing and reaching epidemic proportions, with the largest increase being seen in developing countries, including South Africa. Among the many complications of diabetes, lower extremity amputations are common, with a leg being lost to diabetes somewhere in the world every thirty seconds. The vast majority of these amputations is preventable and is a reflection of inadequate care of diabetic patients. Stu

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Kneafsey, Rosie. "An exploration of the contribution of nurses and care assistants to patients’ mobility rehabilitation." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3242/.

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Aim of the thesis: To report on a study to describe and explain the contribution of registered nurses’ and care assistants’ to hospitalised patients’ mobility rehabilitation. Background: Studies internationally have shown that older adults often experience a decrease in their ability to mobilise during and after hospitalisation. Rehabilitation nursing interventions could be important in maximising the functional abilities of this population. Methods: A grounded theory approach structured data collection and analysis. Data were derived from three hospital settings (general rehabilitation, spina

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22

Macdonald, Catriona. "Live long in Scotland : the relative contribution of medicine and standards of living to Scotland's falling mortality rates." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29236.

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Between 1950 and 1999 the Scottish death rate, standardised to the 1950 population, declined from 13.1 per 1000 to 7.8 for men and from 12 per 1000 to 6.3 for women. The main aim of this thesis has been to establish the key influences on this doctrine. Thomas McKeown examined the decline of mortality in an earlier time period (up to the 1970s) and concluded that: falls in deaths from infectious diseases were responsible for the majority of the decline in mortality rate; and the main influence on their decline was standards of living, in particular diet. The causes of death which contributed mo

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23

Au, Bo Ting. "Regulation of IL-8 release from phagocytosing human neutrophils in vitro, and the contribution of neutrophil-derived IL-8 in a rabbit peritonitis model." Thesis, Imperial College London, 1994. http://hdl.handle.net/10044/1/7513.

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24

Tipping, Nigel. "The characteristics of older persons who present at a tertiary emergency unit; in particular, the contribution of adverse drug events : a prospective cross-sectional study." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/2786.

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25

Pooley, Hannah. "A contribution to the understanding of healthcare relationships in long term health conditions." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58607/.

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Chronic illnesses are the leading cause of death worldwide and are also expected to be the leading cause of disability by 2020 (World Health Organization [WHO], 2003). They are changing the experience of healthcare for both patients and healthcare professionals. In particular, they are changing the roles of patients and doctors, with patients expected to be more involved in their disease management and doctors shifting their focus away from curing pathology to regulating and palliating symptoms (May, 2005). Chapter one presents a systematic review of the role of patients' relationship styles o

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Ichim, Daniela. "Uncontrolled blood pressure among hypertensive older adult patients in family practice settings: The contribution of physician and patient characteristics." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28557.

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Objective: To determine the patient and physician characteristics associated with blood pressure control among older hypertensive patients in family practice, the prevalence of hypertension and the percent of hypertensive patients with controlled blood pressure. Methods: A systematic review has been performed of published studies which reported an analysis of the association between patient and physician characteristics and hypertension control; Data collected in a retrospective review of patients' health records in 28 family practices and a questionnaire for the participating family physician

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Bailey, Di. "Being with, as opposed to, doing to : a contribution to mental health research to transform education and practice." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/63109/.

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My substantial, original contribution to mental health research, education and practice spans 17 years, from the mid 1990s to the present day. It is a journey on which I consider I am still travelling, during which the landscape of mental health services and the workforce that delivers them has changed in an unprecedented fashion. It has been a privilege to have contributed to this metamorphosis which began with my research into diversion schemes for mentally disordered offenders (MDOs) moving onto interdisciplinary mental health education/training and workforce redesign. Latterly, my to contr

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Asquith, Darren Lee. "The role of the liver X receptors in inflammation : exploring their contribution to articular pathology." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1796/.

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The Liver X receptors, LXRα and LXRβ, belong to the superfamily of nuclear receptor ligand activated transcription factors. LXRs have been well characterised in the context of metabolism through their ability to induce reverse cholesterol transport leading to the excretion of cholesterol from the body. More recently, LXRs have been shown to play a role in inflammation in which they are often ascribed an anti-inflammatory effect. Rheumatoid arthritis (RA) is a chronic auto-immune condition manifest as inflammation of the diarthrodial joints predominantly in the hands and feet. It is now well re

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Richards, L. "The role and contribution of lay community food advisor programmes to public health in Canada." Thesis, City, University of London, 2018. http://openaccess.city.ac.uk/20426/.

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INTRODUCTION: Having members within communities as ‘natural helpers’ may ensure good understanding of local health issues and better delivery of relevant messages. Lay Community Food Advisors (LCFA) may be an effective means to increase coverage of health promotion, empower individuals and communities, help to reduce social exclusion and address the gap in nutritional inequalities. LCFAs may increase awareness of healthy eating and help people translate advice into practice thereby positively influencing patterns of behaviour. However, there is limited evidence supporting these programmes, par

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Rabie, Ursula. "The contribution of the placenta to the diagnosis of congenital tuberculosis." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86623.

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Thesis (MMed)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically suspected tuberculosis (TB) had evidence of TB in the placenta. A secondary objective was to correlate evidence of placental TB with neonatal outcome. A total of 56 placentas were examined to determine if there were any specific histopathological features predictive of tuberculosis together with Ziehl-Neelsen (ZN) staining. A total of 30 cases were positive for maternal TB and one case was a false positive maternal diagnosi

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Gartland, Clare. "'Cultivating rough diamonds' : a study of student ambassadors' contribution to widening participation schemes in engineering and medicine at two contrasting universities." Thesis, UCL Institute of Education (IOE), 2012. http://eprints.ioe.ac.uk/19996/.

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32

Junejo, Rehan Talib. "Contribution of oxygen-dependent mechanisms to vascular responses of exercise in young and older men : the role of prostaglandins and adenosine." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7252/.

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Previous work suggests vasodilating prostaglandins (PGs) are released during isometric handgrip exercise in an O\(_2\)-dependent manner in young men. This project investigates their contribution to the exercise hyperaemia of isometric and rhythmic handgrip contraction performed by healthy, recreationally-active young and older men. Hyperoxia (40% O\(_2\)), aspirin, and their combination equally attenuated exercise and post-exercise hyperaemia, and venous efflux of PGE\(_2\) and PGI\(_2\) in both age groups: efflux of these PGs was not attenuated with age, but their contribution to the hyperaem

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Grief, Gail. "Disturbance in the control of heart rate during exercise following intracardiac repair : contribution of the cardiopulmonary bypass surgery." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61106.

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This study was designed therefore, to investigate potential contributions of the cardiopulmonary bypass (CPB) procedure to the chronotropic limitation during exercise in surgically corrected CHD adolescents. Patients were divided into 3 groups: operated ventricular septal defect, where CPB is required (VSDop: n = 15); VSD closed spontaneously, no surgery or CPB required (VSDnop: n = 17); and operated patent ductus arteriosus, where surgery does not require CPB (PDA: n = 20). Fifteen healthy age-matched subjects served as the control group (C). All subjects were submitted to a graded maximal ex

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Elmadani, Ahmed Elkhidir. "An investigation of the contribution of Single Photon Emission Computed Tomography to the diagnosis of skeletal metastases using bone scan in the African context." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53279.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: Planar bone scintigraphy is highly sensitive but it may not be sensitive enough to detect subtle lesions in complex bony structures such as the spine. The accurate anatomic localisation of lesions in regions such as this is also limited using planar images. Single Photon Emission Computed Tomography (SPECT) results in a higher lesion contrast resulting in an improved sensitivity for the detection of subtle lesions. SPECT also enables improved lesion localisation, often valuable in distinguishing benign from malignant dise

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Nagelli, Christopher. "Sensorimotor Contribution to Joint Dysfunction following Anterior Cruciate Ligament Injury and Neuromuscular Training as a Clinical Tool to Recover Sensorimotor Control." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500287443874928.

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Bazyler, Caleb D., Jacob R. Goodin, Tara K. Whiton, Satoshi Mizuguchi, and Michael H. Stone. "The Contribution of Muscle Cross-Sectional Area to Jump Height in Collegiate Athletes." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/3832.

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PURPOSE: To determine the relative contribution of vastus lateralis (VL) and lateral gastrocnemius (LG) cross-sectional area (CSA) to countermovement jump height (JH) in collegiate athletes. METHODS: Sixty-nine male (n=33, 20.43 ± 1.68 y, 180.34 ± 11.39 cm, 77.54 ± 14.45 kg) and female (n=36, 19.79 ± 1.09 y, 168.46 ± 10.07 cm, 67.33 ± 9.48 kg) collegiate athletes competing in basketball, tennis, cross-country, weightlifting, and volleyball were recruited for the study. Testing was conducted as part of an on-going athlete monitoring program. Athletes were tested on measures of VL and LG CSA usi

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Lupino, Lauren. "Investigating the contribution of aberrant sphingosine 1-phosphate signalling to the pathogenesis of diffuse large B-cell lymphoma." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7386/.

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There is an increasing body of evidence indicating an important role for the bioactive signalling lipid S1P (sphingosine 1-phosphate) in cancer. Sphingosine kinase-1 (SPHK1), one of the enzymes responsible for the synthesis of S1P, is reported to be overexpressed in many cancer types; in many cases correlating with increased tumour grade and reduced patient survival. However, the expression of SPHK1, and how it might contribute to lymphomagenesis, has not previously been explored in diffuse large B-cell lymphoma (DLBCL). In chapter 3, I show that SPHK1 overexpression in DLBCL correlates with t

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Strange, Heather Ruth. "Mechanism of Iron Transport Employed by Neisseria Gonorrhoeae: Contribution of Ferric Binding Protein A." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/80.

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FbpA is the periplasmic binding protein of the transferrin and lactoferrin-iron transport systems. FbpA is conserved among neisserial species and is required for Neisseria gonorrhoeae to sustain growth on transferrin and lactoferrin. The identification of other putative TonB-dependent outer membrane transporters suggests that gonococci may employ other uncharacterized iron uptake systems that do not require FbpA. Previous work in our lab demonstrated that gonococcal strain FA19 utilizes iron from a number of xenosiderophores of the catecholate and hydroxamate classes. In this study we cre

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Jones, Davon I. "Upper versus Lower Body Contribution to the Rowing Stroke." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1323968844.

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Hickson, Kerry. "The contribution of improved health to standards of living in twentieth century England and Wales." Thesis, London School of Economics and Political Science (University of London), 2006. http://etheses.lse.ac.uk/22/.

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The thesis will highlight both qualitatively and quantitatively that during the twentieth century the English population experienced unprecedented improvements in mortality and particularly morbidity, which has provided a substantial boost to standards of living and economic development. Despite the extensiveness of these health improvements, there have been a very limited number of attempts to evaluate and quantify these valuable improvements. None of the existing studies that quantitatively assess improved health actually measure health per se, as they all utilise mortality as a proxy. Furth

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Elius, Ian M. "Re-engineering graduate medical education an analysis of the contribution of residents to teaching hospitals utilizing a model of an internal medicine residency program /." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001258.

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Wilhelmsson, Margaretha. "Developing Interprofessional Competence : Theoretical and Empirical Contributions." Doctoral thesis, Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69603.

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Background: Different professions meet and work together in teams every day in health and social care. In order to idenUiy and deliver the best quality of care for the patient, the teamworkers need to be both professionally and interprofessionally competent. How can higher education prepare teamworkers to be both professionillly and interprofcssionally competent? This thesis seeks to contribute theoretically and empirically to this issuc. A starting point for interprofessional education (WE) worldwide was when WHO presented a document entitled "Leaming Together to Work Together for Bdter Healt

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Ma, Yuk Ting. "An investigation of the contribution of cigarette smoking and human papillomavirus infection to the epigenetic modulation of cellular genes in cervical epithelium." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1348/.

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In this thesis, I examine the contribution of cigarette smoking and human papillomavirus infection, two independent risk factors for cervical neoplasia, to the epigenetic modulation of cellular genes in cervical epithelium. To determine the temporal relationship between cigarette smoking and the detection of CDKN2A methylation in cervical cytological samples, I used a unique cohort of 2011 women aged 15-19 who were recruited soon after they first had sexual intercourse. I have shown that compared with never-smokers, women who first started to smoke during follow-up had an increased risk of acq

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Ah, Goo Delia Felecia Stephanie. "The contribution of the trade in medicinal plants to urban livelihoods: a case study of the informal markets in Nelson Mandela Bay Municipality, Eastern Cape." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1011601.

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The commercialisation of natural resources such as medicinal plants is a strategy that is increasingly being employed by poor people in developing countries such as South Africa, as a means of generating an income. Increasing economic hardship and a lack of employment opportunities in the formal sector of the economy has led to many urban dwellers seeking alternative means of meeting their everyday livelihood needs. Although the contribution of natural resources to subsistence economies is widely recognised, there are few studies that have examined the significance of the trade in medicinal pl

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Woolard, Stacie N. "The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1672.

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Natural killer (NK) cells are non-specific killer cells of the innate immune system that eliminate target cells based on discrimination between self and non-self. Activation is carefully regulated through integration of signals received through both activating and inhibitory receptors. During the course of a herpes simplex virus type-1 (HSV-1) infection, NK cells can influence host susceptibility to infection with severe infections occurring in individuals with genetic defects in the NK cell response. In response to HSV infection, NK cells are recruited to the inflammatory tissue where ensuing

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Balestra, Costantino. "Is the patency of the cardiac foramen ovale a risk factor for disbaric pathologies: contribution to diving research and fostering diving safety." Doctoral thesis, Universite Libre de Bruxelles, 2003. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241291.

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Kathiriya, Jaymin J. "Contribution of Epithelial Hypoxia Signaling to Pulmonary Fibrosis: Role of FAK1 and Galectin-1 as Driver Molecules." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6523.

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Abstract:

Idiopathic Pulmonary Fibrosis (IPF) is a deadly disease of unknown origin, which causes 80,000 deaths every year in the US and Europe combined. Unknown etiology and late diagnosis, combined with limited treatment options, contribute to a dismal survival rate of 3-5 years post diagnosis. Although molecular mechanisms underlying IPF pathogenesis and progression have been studied for over two decades, lack of in vivo models that recapitulate chronic, progressive, and irreversible nature of IPF have contributed to limited therapeutic success in clinical trials. Currently, only two drugs, Pirfenido

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Freitas, João Pedro Pinto de Almeida. "Síndromas de intolerância ortostática. Contributo para o seu esclarecimento." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/55337.

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Freitas, João Pedro Pinto de Almeida. "Síndromas de intolerância ortostática. Contributo para o seu esclarecimento." Tese, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/55337.

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Haem, Rahime Muzhda. "Exploration des trajectoires immuno-inflammatoires des patients de réanimation : contribution à l'utilisation des biomarqueurs en pratique clinique pour guider les stratégies d'immunothérapie." Electronic Thesis or Diss., Lyon 1, 2025. http://www.theses.fr/2025LYO10015.

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Lors des épisodes d’inflammation systémique (sepsis, traumatisme, chirurgie), les patients présentent des réponses immuno-inflammatoires complexes et hétérogènes, tant en intensité qu’en évolution temporelle. Ces réponses combinent simultanément une réaction inflammatoire exacerbée et des mécanismes anti-inflammatoires compensatoires, susceptibles de devenir immunosuppresseurs. La complexité de ces mécanismes explique en partie l’échec des thérapies immunomodulatrices développées depuis des décennies selon une approche dite « one size fits all ». Aujourd’hui, la prise en charge des patients s’

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