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Dissertations / Theses on the topic 'Control by RNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Xu, Ning. "Adenoviral Control of RNAi/miRNA Pathways in Human Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distribution], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9387.

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2

Fritz, Sarah E. "Molecular basis of the DExH-box RNA helicase RNA helicase A (RHA/DHX9) in eukaryotic protein synthesis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437413252.

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3

Giacometti, Simone. "CBC bound proteins and RNA fate." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS028.

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Le complexe de liaison de la coiffe des ARN (CBC) joue un rôle essentiel dans leur maturation et déclenche une variété de réactions biochimiques, via son interaction avec différents partenaires. Deux complexes, CBC-ARS2-PHAX (CBCAP), et CBC-ARS2-ZC3H18-NEXT (CBCN), ont récemment été montré comme important pour cibler les ARN vers l'export (CBCAP) ou la dégradation (CBCN). Cependant, les mécanismes par lesquels la sélection se fait pour l'une voie ou l'autre reste mystérieuse. Ainsi, une question majeure qui reste à résoudre est de savoir quand et comment ces complexes sont recrutés sur les ARN

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4

Hitchcock, Robert Arthur. "Epigenetic control of the kinetoplastid spliced leader RNA." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1998392041&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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5

Wilson, Sean. "Control of messenger RNA stability in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368535.

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The effect of glucose on ribosomal protein mRNA stability was examined. The addition of glucose, to a final concentration as low as 0.01%, resulted in a dramatic, transient increase in ribosomal protein mRNA stability. It has been demonstrated that protein kinase A (PKA) activity plays an important role in the up-regulation of ribosomal protein gene transcription in response to glucose addition. PKA pathway is required for the transient stabilisation of ribosomal protein mRNA following glucose addition, mRNA half-lives were determined in a PKA mutant strain. The data indicated that this glucos

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6

Brown, Justin Travis. "MRNA degradation in the control of gene expression in yeast." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3024999.

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7

Carlberg, Konstantin. "In Situ RNA Quality Control : A spatial heat map of RNA integrity with single cell resolution." Thesis, KTH, Skolan för bioteknologi (BIO), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176873.

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The quality of RNA is of great importance in gene expression studies. It is mostly measured using the RNA integrity number (RIN). Lately it has been shown that samples with low RIN and different fragmentation patterns could affect quality of sequencing data. For such low RIN samples a new approach has been developed by Illumina called the DV200 metric, which is the percentage of fragments >200 nucleotides. For samples with low RIN, DV200 has proved to be a better method to predict if good quality data from RNA sequencing can be generated. However, neither RIN nor DV200 provide spatial infro

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8

Zhang, Ze. "The control of ribosomal RNA synthesis in mammalian cells." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/350477/.

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The biogenesis of ribosomes is a fundamental process that occurs in all living cells. In mammalian cells, it is a highly complex process consisting of the coordinated synthesis and assembly of four ribosomal RNAs (rRNAs) with about 80 ribosomal proteins (RPs). More than 150 non-ribosomal proteins are involved in the processing of rRNAs. The main focus of this project is to use adult rat ventricular cardiomyocytes (ARVCs) as a model to address how mTOR complex 1 (mTORC1) and other signalling pathways regulate the synthesis of rRNAs. A new technique has been developed to monitor the synthesis of

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9

Tzelos, Thomas. "RNA interference in parasitic nematodes : from genome to control." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15906.

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Teladorsagia circumcincta is a parasitic nematode which is a major cause of ovine parasitic gastroenteritis in temperate climatic regions. The parasite has developed resistance to the major anthelmintic drug classes and this challenges its future control. Vaccination is a potential alternative control method since sheep are able to develop protective immunity against this parasite. Although potential vaccine candidates have been revealed, the increasing gene datasets suggest that vaccinetarget selection may be aided by screening methods such as RNAi. This is a reverse genetic mechanism that ca

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10

Peele, Price Jason. "Control of RNA Structure by CspA Proteins in Rhizobia." Thesis, Washington State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10605605.

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<p> Rhizobia are soil bacteria that can associate with some legumes and participate in symbiotic nitrogen fixation. Bacterial CspA family members are small, single stranded nucleic acid binding proteins conserved throughout all domains of life. Here, the role of CspA family proteins in the symbiotic development of <i>Sinorhizobium meliloti</i> with <i>Medicago sativa</i> (alfalfa) is investigated. Expression and genetic deletion strain analysis revealed that CspA family proteins are differentially expressed in symbiosis and contribute to symbiotic effectiveness. RNAseq analysis of native co-im

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11

Butsch, Melinda Sue. "Control of Retroviral Translation and Relationship to Genomic RNA Packaging." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1029510697.

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12

Ranji, Arnaz K. "Mechanistic insights into translational modulation of selected RNAs by RNA helicase A." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299537544.

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13

Soto-Rifo, Ricardo. "Translational control of HIV-1 and HIV-2 genomic RNA." Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0584.

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Les virus de la immunodéficience humaine de type 1 et 2 (VIH-1 et VIH-2) sont des pathogènes qui ont un grand impact sur la santé car plus de 33 millions de personnes sont infectées dans le monde. Les mécanismes qui contrôlent les étapes post-transcriptionelles de l’ARN génomique pendant les étapes tardives du cycle réplicatif ne sont pas très connu et donc les processus moléculaires qui permettent à l’ARN génomique de s’associer aux machineries cellulaires de traduction, transport ou dégradation restent à être déterminés. Dans ces travaux, nous avons contribué à améliorer notre connaissance s

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14

Smith, Richard Wilson. "RNA metabolism and the control of protein synthesis in fish." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU089891.

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This thesis examines the regulation of protein synthesis by pre - translational events; with particular reference to the means by which RNA is able to reduce the energetic cost of protein synthesis. Protein synthesis was measured by the application of a "flooding dose" of 3H-phenylalnine. Protein synthesis rates are then calculated from the "free intracellular" and "protein bound" specific radioactivity (dpm nmole-1 phenylalanine). A similar approach was used to investigate RNA synthesis: i.e. a flooding dose of 3H-uridine. As with protein synthesis RNA synthesis rates was assessed by the rela

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15

Bolinger, Cheryl Giles. "Study of translation control by a RNA helicase A-responsive post-transcriptional control element in Retroviridae." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1226513076.

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16

Hasan, Ayesha. "Global control of RNA turnover in the fission yeast Schizosaccharomyces pombe." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708613.

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17

Mehlhorn, Sonja Gabriele [Verfasser]. "RNA interference: Process and Application to Pest Control / Sonja Gabriele Mehlhorn." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1214887066/34.

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18

Sardana, Ravinder Kumar. "Structure and control of expression of ribosomal RNA genes in wheat." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305819.

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19

Murphy, Alexander James. "RNA and Protein Networks That Locally Control Brain Wiring During Development." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467385.

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The molecular machineries of growth cones control the formation of neural circuits in the developing brain. Although great progress has been made in elucidating axon guidance cues and their growth cone receptors, we still lack an understanding of the projection-specific RNA and protein networks in growth cones that likely control the wiring of specific circuits in vivo. To understand how specific projection neurons make wiring decisions, I focus on callosal projection neurons (CPN), which connect the two cerebral hemispheres through the corpus callosum. I developed an approach to profile and q

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20

Ulbricht, Randi J. "Puf1p-mediated mRNA decay and combinatorial control of mRNA stability by the yeast Puf proteins." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2008. http://etd.umsl.edu/r2761.

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21

Lichtenberg, Stuart. "Nanomaterials for Double-Stranded RNA Delivery." UKnowledge, 2019. https://uknowledge.uky.edu/pss_etds/124.

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RNA interference has enormous potential as a potent, specific, and environmentally friendly alternative to small molecule pesticides for crop protection. The use of exogenous double-stranded RNA offers flexibility in targeting and use in crops in which transgenic manipulation is not an option. The combination of RNAi with nanotechnology offers further advantages that are not available with dsRNA alone. In this work, I have evaluated several different combinations of nanomaterials and polymers for use in RNAi-based pest control systems. First, I have characterized the use of chitosan/dsRNA poly

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22

Chen, Augustine, and n/a. "Translational control mechanisms used by the human Hepatitis B virus : an upstream open reading frame modulates expression of the pregenomic RNA." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080130.123000.

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The human hepatitis B virus (HBV) is a small hepatotropic virus, which affects approximately 350 million chronic sufferers worldwide. It has a compact 3.2 kbp dsDNA genome encoding four major overlapping genes namely core, polymerase, surface and X required for its replication. The virus synthesises a pregenomic RNA (pgRNA) which functions both as an RNA intermediate for reverse transcription into the DNA genome and as the mRNA for the translation of the core (C) and polymerase (P) proteins. The core overlaps the polymerase gene and is translated at a 10 to 1 ratio. The polymerase gene transla

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23

Séguin, Béatrice. "Control of HIV-1 RNA metabolism, the role of splice sites and intron sequences in unspliced viral RNA subcellular distribution." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/MQ40793.pdf.

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24

Kaufman, Ethan Joshua. "MicroRNA control of excretory cell development in C. elegans." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609988.

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25

Kew, Chun [Verfasser], and Adam [Gutachter] Antebi. "Control of Innate Immunity by RNA Metabolism / Chun Kew ; Gutachter: Adam Antebi." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1180601556/34.

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26

Santos, Viviane. "Riqueza e alterações morfofisiológicas associadas à infecção por vírus de RNA de fita dupla no fungo entomopatogênico Metarhizium anisopliae." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11146/tde-26042013-162222/.

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O Brasil é o país líder no uso do fungo entomopatogênico Metarhizium anisopliae para o controle pragas agrícolas. Pouco se conhece sobre a diversidade e o impacto dos micovírus em M. anisopliae sensu stricto. Este trabalho mostra a riqueza dos micovírus associados a isolados de M. anisopliae da coleção de entomopatógenos da Universidade de São Paulo, usinas sucroalcooleiras e produtos microbianos à base do entomopatógeno. RNAfd foram encontrados em 55% dos 36 isolados de Metarhizium e apresentaram 16 diferentes padrões eletroforéticos consistindo de 3 a 18 bandas de RNAfd em gel de poliacrilam

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27

Costa, Pedro Rafael [UNESP]. "Modelo cinético estocástico para a transcrição considerando colisões entre as moléculas de RNA polimerase." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92463.

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Made available in DSpace on 2014-06-11T19:26:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-09-03Bitstream added on 2014-06-13T20:53:59Z : No. of bitstreams: 1 costa_pr_me_botib.pdf: 664900 bytes, checksum: d4b731cf5ba2463de35082d25d1fdb1e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A transcrição realizada pela RNA polimerase (RNAP) é um processo cuidadosamente controlado no desenvolvimento e na manutenção das funções vitais dos organismos. O desenvolvimento de novas técnicas e equ

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Costa, Pedro Rafael. "Modelo cinético estocástico para a transcrição considerando colisões entre as moléculas de RNA polimerase /." Botucatu, 2012. http://hdl.handle.net/11449/92463.

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Orientador: Ney Lemke<br>Banca: Scheila de Ávila e Silva<br>Banca: José Luiz Rybarczyk Filho<br>Resumo: A transcrição realizada pela RNA polimerase (RNAP) é um processo cuidadosamente controlado no desenvolvimento e na manutenção das funções vitais dos organismos. O desenvolvimento de novas técnicas e equipamentos para seu estudo, como as técnicas de pinça ótica ou magnética, a microscopia de força atômica e a fiuorescência de molécula única, complementaram os resultados dos estudos bioquímicos tradicionais e nos levaram a um maior entendimento do processo. A ocorrência de "pausas" em sítios e

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29

Kemp, Alain. "Regulation of developmental differentation control by changes in tRNA decoding efficiency in yeast." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=166224.

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The yeast Saccharomyces cerevisiae decodes CAG codons using tRNAGlnCUG, encoded by the single-copy gene SUP70. On rich medium, the sup70-65 and sup70-33, alleles induce pseudohyphal growth, ordinarily a response to nitrogen limitation. sup70-65 tRNA is additionally a UAG stop codon suppressor. Characterisation of sup70 diploids revealed that they form pseudohyphal-like structures on both rich and N-deprived liquid, but not solid medium. Unlike canonical pseudohyphae, which bud in a unipolar fashion and are RAS2Val19 stimulated, sup70 pseudohyphal cells budded in a bipolar fashion that was RAS2

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30

Pizzinga, Mariavittoria. "Granules of translation factor mRNAs and their potential role in the localisation of the translation machinery to regions of polarised growth." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/granules-of-translation-factor-mrnas-and-their-potential-role-in-the-localisation-of-the-translation-machinery-to-regions-of-polarised-growth(9cb42e69-3c8c-4f10-b79f-ba8261be4430).html.

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The subcellular localisation of mRNA is a widespread mechanism to determine the fate of mRNAs in eukaryotes. Translationally repressed mRNAs localise to P-bodies and stress granules where their decay and storage, respectively, are directed. In a study from the Ashe lab, specific mRNAs were identified to localise, in actively growing S. cerevisiae, to cytoplasmic granules that do not seem to be related to P-bodies or stress granules but appear to be associated with active translation (Lui et al., 2014).It is possible that this might represent a strategy to co-regulate the expression of proteins

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31

Kabnick, Karen Stephanie. "A novel approach for the study of sequences that control cytoplasmic RNA stability." Thesis, Massachusetts Institute of Technology, 1987. https://hdl.handle.net/1721.1/121909.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.<br>Bibliography: leaves 190-202.<br>by Karen Stephanie Kabnick.<br>Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.

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32

Stanoszek, Lauren M. "Biospecimen RNA Quality Control in Reverse-Transcription, Quantitative PCR (RT-qPCR) Clinical Tests." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1430323793.

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33

Aung-Htut, May Thandar Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Characterisation of Escherichia coli GTPase Der reveals previously unknown regulation by RNA." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41840.

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GTPases are found in all domains of life and are highly conserved. In eukaryotes, they serve as signalling molecules for many cellular processes. However, the prokaryotic GTPases play a very different role and are found to be associated with ribosome function. Among the 11 conserved GTPases, Der is the most interesting in prokaryotes. It possesses a unique structure with two GTPase domains (G-Domains) tethered by a variable length acidic linker and a carboxyl terminal KH-like domain. The exact function of Der is still under investigation and most of the data suggest that it is important for 50

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34

Roberts, Tiffiney Marie. "Redundant structural motifs in a unique retroviral posttranscriptional control element mediate a novel mechanism of translational enhancement." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1066927045.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 165 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Kathleen Boris-Lawrie, Dept. of Molecular, Cellular and Developmental Biology. Includes bibliographical references (p. 148-165).

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35

Bardella, Daniela Zardini. "Silenciamento gênico via RNAi visando o controle da broca da cana-de-açúcar (Diatraea saccharalis)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/64/64133/tde-01022016-172023/.

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A cana-de-açúcar (Saccharum spp.) é uma importante cultura na produção de alimentos e energia. Várias espécies de insetos podem causar sérios prejuízos econômicos à cultura da cana-de-açúcar. A broca da cana-de-açúcar (Diatraea saccharalis) é a praga de maior relevância por estar amplamente distribuída nas regiões canavieiras. O silenciamento gênico por RNA de interferência (RNAi) se tornou uma técnica amplamente estudada e utilizada nos mais diversos aspectos da biologia. Uma de suas aplicações é no controle de insetos-praga como uma alternativa de alta eficiência, especificidade e reduzido i

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36

Loomis, Wendy Pulkkinen. "Translational control of messenger RNA processing in the F1845 fimbrial operon of Escherichia coli /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11507.

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Jones, Steven Tarran. "The role of the #beta# subunit of E. coli DNA-dependant RNA polymerase in stringent control." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232905.

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Jenkins, Adam. "Analysis of anopheline mosquito behavior and identification of vector control targets in the post-genomic era." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104489.

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Thesis advisor: Marc A.T. Muskavitch<br>The protozoan Plasmodium falciparum, the mosquito-borne pathogen that causes human malaria, remains one of the most difficult infectious parasites to combat and control. Campaigns against malaria eradication have succeeded, in most instances, at the level of vector control, rather than from initiatives that have attempted to decrease malaria burden by targeting parasites. The rapid evolution and spread of insecticide-resistant mosquitoes is threatening our ability to combat vectors and control malaria. Therefore, the development, procurement and distribu

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Machado, Madson Cruz. "Sintonia RNA-RBF para o Projeto Online de Sistemas de Controle Adaptativo." Universidade Federal do Maranhão, 2017. http://tedebc.ufma.br:8080/jspui/handle/tede/1744.

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Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-07-18T19:31:22Z No. of bitstreams: 1 MadsonMachado.pdf: 3046442 bytes, checksum: 71cc6800f83fdbf38b97607067653f63 (MD5)<br>Made available in DSpace on 2017-07-18T19:31:22Z (GMT). No. of bitstreams: 1 MadsonMachado.pdf: 3046442 bytes, checksum: 71cc6800f83fdbf38b97607067653f63 (MD5) Previous issue date: 2017-05-26<br>The need to increase industrial productivity coupled with quality and low cost requirements has generated a demand for the development of high performance controllers. Motivated by this demand, we presented in this work

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40

Bing, Xin Y. "Mechanistic Basis for Control of Early Embryonic Development by a 5’ tRNA Fragment." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1035.

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Ancestral environmental conditions can instruct offspring development, although the mechanism(s) underlying such transgenerational epigenetic inheritance is unclear. In murine models focused on paternal dietary effects, we and others have identified tRNA fragments (tRFs) in mature sperm as potential carriers of epigenetic information. In our search for molecular targets of specific tRFs, we observed that altering the level of 5’-tRF Glycine-GCC (tRF-GG) in mouse embryonic stem cells (mESCs) and preimplantation embryos modulates the expression of the endogenous retrovirus MERV-L and genes regul

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Luhtala, Natalie. "LSM1 AND RNY1: CLUES IN THE SEARCH FOR HOW RNA METABOLIC PATHWAYS CONTROL CANCER." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/204114.

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Carcinogenesis requires numerous alterations to gene expression to evade normal controls on cellular growth, invasion, and immortality. Traditionally, these changes have been examined in the context of deregulated transcriptional control of oncogenes and tumor suppressors. However, in recent years, research has revealed that processes outside of transcription such as RNA splicing, translation, and decay are also deregulated in cancers, sustaining tumorigenic potential. This dissertation details our investigation into the cellular functions of two RNA metabolic proteins whose human orthologs

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42

Black, E. J. "Studies on the use of antisense RNA to control gene expression in Nicotiana tabacum." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/38236.

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McFarland, Matthew R. "Transfer RNAs as regulatory agents in the translational control of gene expression." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231855.

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Translational efficiency is dictated in part by the availability of charged transfer RNA. Depletion of aminoacylated tRNAs (e.g. during recombinant protein expression) can increase translational errors and associated stress responses. Here, the role of tRNAs as regulators of gene expression was explored through development of synthetic, tRNA-regulated gene circuits, and through an investigation of the impact of tRNA aminoacylation on endogenous gene expression. Synthetic gene circuits initially explored the use of dominant negative alleles of the release factor eRF1 to modulate stop codon read

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Sharma, Amit. "Functional control of HIV-1 post-transcriptional gene expression by host cell factors." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1330658547.

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45

Hull, Stacey Lynn. "Identification and Characterization of New and Distinct Functional Roles of Posttranscriptional Control Elements in Cytoplasmic Expression of Retroviral RNA." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1038349636.

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46

Bronicki, Lucas M. "Characterization of Multiple Exon 1 Variants and Neuron-specific Transcriptional Control of Mammalian HuD." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23682.

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The RNA-binding protein (RBP) and Hu/ELAV family member HuD regulates mRNA metabolism of genes that encode proteins involved in neuronal differentiation, learning and memory, and certain neurological diseases. Given the important functions of HuD in a variety of processes, we set out to characterize the 5’ genomic region of the mammalian HuD gene and determine the mechanisms that regulate its mRNA expression in neurons using P19 cells and mouse brain as models. Bioinformatic and 5’RACE (rapid amplification of cDNA ends) analyses of the HuD 5’ genomic flanking region identified eight conserved

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47

Thakur, Noopur. "Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5725.

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Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). To elucidate the mechanisms by which the imprinting is maintained in clusters, we have chosen a well characterized cluster at the distal end of mouse chromosome 7. This cluster contains 15 imprinted genes and they have been shown to be regulated by H19 and Kcnq1 ICRs. The mouse H19 ICR, which is shown to have

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Stevenson, Michael Andrew. "RNA interference as a tool to control plant parasitic nematode infestation in key plant crops." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677278.

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The work presented in this thesis documents studies on the impact of RNA interference (RNAi) on potential control target genes and how this alters the phenotype of the pre-parasitic stage of the plant parasitic nematodes (PPN), Globodera pallida and Meloidogyne incognita. A wide range of targets were selected across all the main tissue types within the worms (hypodermis, muscle, nervous system, subventral gland, dorsal gland) and significant knockdown was achieved (using short-interfering [si]RNAs) in all tissue types except the dorsal gland. Overall, the data strongly support the utility of P

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Hoyos, Mona [Verfasser], and Kai [Akademischer Betreuer] Papenfort. "Principles of RNA-based gene expression control in Vibrio cholerae / Mona Hoyos ; Betreuer: Kai Papenfort." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1227188471/34.

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Sweet, Thomas Jeffrey. "New Insights Into the Relationship Between Messenger RNA Translation and Degradation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1321298653.

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