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Journal articles on the topic 'Control flowgraph'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Al-Dabbagh, Ahmad W., and Lixuan Lu. "Reliability modeling of networked control systems using dynamic flowgraph methodology." Reliability Engineering & System Safety 95, no. 11 (2010): 1202–9. http://dx.doi.org/10.1016/j.ress.2010.05.005.

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Al-Dabbagh, Ahmad W., and Lixuan Lu. "Dynamic flowgraph modeling of process and control systems of a nuclear-based hydrogen production plant." International Journal of Hydrogen Energy 35, no. 18 (2010): 9569–80. http://dx.doi.org/10.1016/j.ijhydene.2010.06.059.

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Tan, Aik Theng, Zurinahni Zainol, and Rahmat Budiarto. "Flowgraph models for estimating total time of authentication process in RFID system." Journal of the Franklin Institute 350, no. 5 (2013): 1298–311. http://dx.doi.org/10.1016/j.jfranklin.2013.03.004.

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Gautam, Pratiksha, and Hemraj Saini. "Non-Trivial Software Clone Detection Using Program Dependency Graph." International Journal of Open Source Software and Processes 8, no. 2 (2017): 1–24. http://dx.doi.org/10.4018/ijossp.2017040101.

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Code clones are copied fragments that occur at different levels of abstraction and may have different origins in a software system. This article presents an approach which shows the significant parts of source code. Further, by using significant parts of a source code, a control flow graph can be generated. This control flow graph represents the statements of a code/program in the form of basic blocks or nodes and the edges represent the control flow between those basic blocks. A hybrid approach, named the Program Dependence Graph (PDG) is also presented in this article for the detection of no

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Csenki, Attila. "Towards a unified view of finite automata and semi-Markov flowgraph models." International Journal of General Systems 38, no. 6 (2009): 643–57. http://dx.doi.org/10.1080/03081070902911550.

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Yau, M., S. Guarro, and G. Apostolakis. "Demonstration of the Dynamic Flowgraph Methodology using the Titan II Space Launch Vehicle Digital Flight Control System." Reliability Engineering & System Safety 49, no. 3 (1995): 335–53. http://dx.doi.org/10.1016/0951-8320(95)00050-c.

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Šotner, Roman, Zdeněk Hruboš, Břetislav Ševčík, Josef Slezák, Jiří Petržela, and Tomáš Dostál. "An Example of Easy Synthesis of Active Filter and Oscillator using Signal Flowgraph Modification and Controllable Current Conveyors." Journal of Electrical Engineering 62, no. 5 (2011): 258–66. http://dx.doi.org/10.2478/v10187-011-0041-z.

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An Example of Easy Synthesis of Active Filter and Oscillator using Signal Flowgraph Modification and Controllable Current Conveyors The paper deals with synthesis of active frequency filters and oscillators for applications in the video band. The synthesis is based on the modified signal flow graph design approach in the current mode. The commercially available high frequency current conveyors and second order structures are used. Basic structure is employing loss-less and lossy current mode integrators in two distributed feedback loops. Some of the used active elements allow to control curren

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Kalfin, Kalfin, Riza Andrian Ibrahim, and Grida Sakti Laksito. "Optimization of White Box Testing by Utilizing Branching and Repeating Structures in Java Programs Using Base Path." International Journal of Mathematics, Statistics, and Computing 2, no. 2 (2024): 85–89. http://dx.doi.org/10.46336/ijmsc.v2i2.98.

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Software testing is a process created to detect anomalies in the operation of a program or system in order to achieve the expected results. White box testing is a software testing method that tests the internal structure, design and program code. This research aims to produce an optimization method for white box testing in Java programs by utilizing branching and repetition structures using the basis path method, as well as analyzing the effectiveness of the proposed method in generating test cases. The Java program tested in this research includes input function calls, loops, branching, and e

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Kikuchi, Shinsuke, Keisuke Miyake, Yuki Tada, et al. "Laser speckle flowgraphy can also be used to show dynamic changes in the blood flow of the skin of the foot after surgical revascularization." Vascular 27, no. 3 (2018): 242–51. http://dx.doi.org/10.1177/1708538118810664.

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Objectives Laser speckle flowgraphy is a new method that enables the rapid evaluation of foot blood flow without contact with the skin. We used laser speckle flowgraphy to evaluate foot blood flow in peripheral arterial disease patients before and after surgical revascularization. Materials and methods A prospective single-center study. Thirty-one patients with 33 limbs that underwent surgical revascularization for peripheral arterial disease were included. Pre- and postoperative foot blood flows were measured on the plantar surface via laser speckle flowgraphy and skin perfusion pressure. The

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Lee, Yaesop, Yanzhou Liu, Karol Desnos, Lee Barford, and Shuvra S. Bhattacharyya. "Passive-Active Flowgraphs for Efficient Modeling and Design of Signal Processing Systems." Journal of Signal Processing Systems 92, no. 10 (2020): 1133–51. http://dx.doi.org/10.1007/s11265-020-01581-8.

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Okhotsimskaya, T. D., N. V. Neroeva, I. V. Zolnikova, N. E. Deryugina, and O. I. Markelova. "Studying ocular blood flow in patients with retinitis pigmentosa using laser speckle flowgraphy." Russian Ophthalmological Journal 17, no. 1 (2024): 40–46. http://dx.doi.org/10.21516/2072-0076-2024-17-1-40-46.

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Retinitis pigmentosa (RP) ranks first in the structure of hereditary retinal diseases. Vasoconstriction is one of the main ophthalmoscopic indications of PR. Laser speckle flowgraphy (LSFG) is a new non-invasive method that allows quantitative assessment of blood flow in the posterior pole of the eye.Purpose: to evaluate changes in blood flow as determined by the LSFG method in the area of the optic nerve head (ONH) and the macular area in PR patients.Material and methods. The study included 16 patients with PR aged 25 to 70 years. The control group consisted of 40 healthy volunteers, comparab

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Fil, А. А., Е. L. Sorokin, and О. V. Kolenko. "Experience in using the capabilities of laser speckle flowgraphy in macular edema associated with retinal vein occlusions (preliminary report)." Modern technologies in ophtalmology, no. 3 (June 1, 2022): 264–69. http://dx.doi.org/10.25276/2312-4911-2022-3-264-269.

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Purpose. To evaluate the features of blood flow in the optic nerve disc (OND) in patients with macular edema on the background of retinal vein occlusions (RVO). Material and methods. The study included 30 patients (30 eyes) with macular edema on the background of acute respiratory viral infections. Their age ranged from 38 to 84 years (on average 60 ± 10.5 years). There were 11 men and 19 women among them. The control group included 15 somatically healthy patients with no vascular pathology of the eye (30 eyes). In addition to the standard ophthalmological examination, all patients underwent a

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Takayama, Shin, Yukihiro Shiga, Taiki Kokubun, et al. "The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/586857.

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The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF). A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed

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Takahashi, Nana, Kota Sato, Naoki Kiyota, Mai Yamazaki, Eriko Kunikane, and Toru Nakazawa. "The effect of a brinzolamide/brimonidine fixed combination on optic nerve head blood flow in rabbits." PLOS ONE 18, no. 12 (2023): e0295122. http://dx.doi.org/10.1371/journal.pone.0295122.

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Purpose The purpose of this study was to investigate the effect of a 1% brinzolamide and 0.1% brimonidine fixed combination (BBFC) on ONH blood flow (BF) in rabbits. Methods A crossover study was conducted on pigmented rabbits; a physiological saline solution, brinzolamide, or BBFC was administered for eight days. ONH BF, intraocular pressure (IOP) and systemic parameters were measured before the eighth day’s first dose and at 6, 9, 12, and 14 hours after the dose. ONH BF was assessed using laser speckle flowgraphy, and mean blur rate (MBR) values were calculated. The percentage against baseli

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Inoue-Yanagimachi, Maki, Noriko Himori, Kota Sato, et al. "Association between mitochondrial DNA damage and ocular blood flow in patients with glaucoma." British Journal of Ophthalmology 103, no. 8 (2018): 1060–65. http://dx.doi.org/10.1136/bjophthalmol-2018-312356.

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Background/AimsWe determined the relationship between tissue mean blur rate (MT) and mitochondrial dysfunction, represented by the mitochondrial/nuclear DNA (mtDNA/nDNA) ratio. We also investigated the usefulness of these biomarkers.MethodsWe assessed ocular blood flow in 123 eyes of 123 patients with open-angle glaucoma (OAG) and 37 control eyes of 37 healthy subjects by measuring MT in the optic nerve head with laser speckle flowgraphy. We measured mtDNA and nDNA with PCR, calculated the mtDNA/nDNA ratio and compared this ratio with MT using Spearman’s rank test. We used multiple regression

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Yokota, Harumasa, Hiroki Hayashi, Junya Hanaguri, et al. "Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes." PLOS ONE 17, no. 1 (2022): e0262568. http://dx.doi.org/10.1371/journal.pone.0262568.

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Prorenin is viewed as an ideal target molecule in the prevention of diabetic retinopathy. However, no drugs are available for inhibiting activation of prorenin. Here, we tested the effect of a prorenin peptide vaccine (VP) in the retina of a murine model of type 2 diabetes (T2D). To choose the optimal vaccine, we selected three different epitopes of the prorenin prosegment (E1, E2, and E3) and conjugated them to keyhole limpet hemocyanin (KLH). We injected C57BL/6J mice twice with KLH only (as a control vaccine), E1 conjugated with KLH (E1-KLH), E2-KLH, or E3-KLH and compared antibody titers.

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Hanaguri, Junya, Noriaki Nagai, Harumasa Yokota, et al. "Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice." Pharmaceutics 14, no. 2 (2022): 384. http://dx.doi.org/10.3390/pharmaceutics14020384.

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We investigated the effect of fenofibrate nano-eyedrops (FenoNano) on impaired retinal blood flow regulation in type 2 diabetic mice. Six-week-old db/db mice were randomly divided into an untreated group (n = 6) and treated group, which received FenoNano (n = 6). The longitudinal changes in retinal neuronal function and blood flow responses to systemic hyperoxia and flicker stimulation were evaluated every 2 weeks in diabetic db/db mice treated with FenoNano (n = 6) or the vehicle (n = 6) from ages 8–14 weeks. The retinal blood flow was assessed using laser speckle flowgraphy. We also evaluate

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Mursch-Edlmayr, Anna S., Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer, and Matthias Bolz. "Differences in Optic Nerve Head Blood Flow Regulation in Normal Tension Glaucoma Patients and Healthy Controls as Assessed With Laser Speckle Flowgraphy During the Water Drinking Test." Journal of Glaucoma 28, no. 7 (2019): 649–54. http://dx.doi.org/10.1097/ijg.0000000000001258.

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Haneda, Mayumi, Yuki Hashimoto, Airi Mishima, Daichi Saito, and Takeshi Yoshitomi. "Changes in choroidal circulation hemodynamics during the menstrual cycle in young, healthy women." PLOS ONE 17, no. 6 (2022): e0270501. http://dx.doi.org/10.1371/journal.pone.0270501.

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Purpose The current study aimed to investigate the time course of changes in choroidal circulation hemodynamics and their relationship to systemic circulation dynamics during the normal menstrual cycle in young, healthy women using laser speckle flowgraphy (LSFG). Methods This prospective study included 26 eyes from 13 young, healthy women (21.3 ± 4.0 years) with a normal menstrual cycle and 24 eyes from 12 young, healthy men (21.8 ± 4.4 years) as a control group. The macular mean blur rate (MBR), a quantitative index of relative blood flow velocity in the choroid, was measured using LSFG. MBR

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McNelles, Phillip, Lixuan Lu, and Marc-James Abi-Jaoude. "Dynamic Flowgraph Methodology Assessment of an FPGA-Based Postaccident Monitoring System for Westinghouse AP1000 Nuclear Power Plants." Journal of Nuclear Engineering and Radiation Science 1, no. 3 (2015). http://dx.doi.org/10.1115/1.4029591.

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A field-programmable gate array (FPGA) is a type of integrated circuit that is programmed after being manufactured. These FPGA-based systems are considered to be viable alternatives to replace many obsolete instrumentation and control (I&C) systems that are used in nuclear plants. This paper describes an FPGA-based lab-scale implementation of a postaccident monitoring system (PAMS), for a Westinghouse AP1000 reactor. This system will monitor vital parameters in the event of a serious reactor accident. The system reliability was analyzed using the dynamic flowgraph methodology (DFM). DFM wa

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Idris, Irma Surya Kumala, and Yasin Aril Mustofa. "Monitoring Fasilitas Pertamanan Kota Gorontalo Berbasis Sistem Informasi Geografis." Jurnal Informatika Upgris 7, no. 1 (2021). http://dx.doi.org/10.26877/jiu.v7i1.5858.

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City Park is part of the city's green open space, its existence has the meaning of securing natural ecosystems that have a great influence on the existence and survival of the city itself. The number of city parks in the city of Gorontalo also requires little cleaning and maintenance personnel. To find out the performance of officers in the field, we need a system that is able to monitor the results of the work, making it easier for the relevant offices to control the conditions, facilities and functions of the city park. This research is intended to build a geographic information system that

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Mubina, Nazmeen, and Rubab Iram. "Data and Control Flow Analysis of VDMµ Specifications." April 23, 2010. https://doi.org/10.5281/zenodo.1079488.

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Formal Specification languages are being widely used for system specification and testing. Highly critical systems such as real time systems, avionics, and medical systems are represented using Formal specification languages. Formal specifications based testing is mostly performed using black box testing approaches thus testing only the set of inputs and outputs of the system. The formal specification language such as VDMµ can be used for white box testing as they provide enough constructs as any other high level programming language. In this work, we perform data and control flow analysis of

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Alsarhani, Waleed K., Fadwa F. Al Adel, Abdullah Alamri, Rahaf M. Al Malawi, and Abdulrahman F. AlBloushi. "Alterations in ocular microcirculation and oxygen metabolism in patients with lipemia retinalis." BMC Ophthalmology 22, no. 1 (2022). http://dx.doi.org/10.1186/s12886-022-02515-7.

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Abstract Purpose The study aims to assess the alterations in retinal oxygen saturation and retinal and choroidal blood flow in lipemia retinalis. Methods This was a cross-sectional study on 10 eyes (5 patients) with history of lipemia retinalis. The study comprised 10 eyes with documented history of lipemia retinalis and 10 participants as healthy controls. Patients with a confirmed history of lipemia retinalis were grouped into two cohorts based on their most recent fundus examination: untreated lipemia retinalis (abnormal fundus) and resolved lipemia retinalis (normal fundus). Both retinal a

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Linton, Edward F., Thomas R. Tedeschi, Noor-Us-Sabah Ahmad, Jui-Kai Wang, and Randy H. Kardon. "Retinal arterial–venous pulse delay: a new specific marker for a carotid–cavernous fistula." Frontiers in Ophthalmology 3 (December 11, 2023). http://dx.doi.org/10.3389/fopht.2023.1301410.

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PurposeThe purpose of the study was to describe ocular blood flow changes in eyes affected by a carotid–cavernous fistula (CCF) using laser speckle flowgraphy. We hypothesized that imaging blood flow velocity waveforms in the retinal arterioles and venules simultaneously would reveal specific characteristics of an arteriovenous (AV) connection.DesignThe study was an observational case series, with a retrospective case–control analysis.MethodsFive patients with a CCF underwent measurement of ocular blood flow using laser speckle flowgraphy. The blood flow was compared retrospectively between a

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"Generating analytical redundancy for fault detection systems using flowgraphs." Control Engineering Practice 2, no. 2 (1994): 352. http://dx.doi.org/10.1016/0967-0661(94)90264-x.

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Itokawa, Takashi, Tadashi Matsumoto, Saiko Matsumura, Momoko Kawakami, and Yuichi Hori. "Ocular blood flow evaluation by laser speckle flowgraphy in pediatric patients with anisometropia." Frontiers in Public Health 11 (February 27, 2023). http://dx.doi.org/10.3389/fpubh.2023.1093686.

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PurposeTo determine the differences and reproducibility of blood flow among hyperopic anisometropic, fellow, and control eyes.MethodsWe retrospectively studied 38 eyes of 19 patients with hyperopic anisometropia (8.2 ± 3.0 years of age) and 13 eyes of eight control patients (6.8 ± 1.9 years). We measured the optic nerve head (ONH) and choroidal circulation using laser speckle flowgraphy (LSFG) and analyzed the choroidal mean blur rate (MBR-choroid), MBR-A (mean of all values in ONH), MBR-V (vessel mean), MBR-T (tissue mean), and sample size (sample), which are thought to reflect the ONH area r

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Yamaguchi, Chiaki, Naoki Kiyota, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, and Toru Nakazawa. "Differentiating optic neuropathies using laser speckle flowgraphy: Evaluating blood flow patterns in the optic nerve head and peripapillary choroid." Acta Ophthalmologica, August 13, 2024. http://dx.doi.org/10.1111/aos.16747.

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AbstractPurposeTo compare blood flow (BF) impairment patterns in different optic neuropathies using laser speckle flowgraphy (LSFG).MethodsThis retrospective study enrolled 24 eyes of 24 patients with non‐arteritic anterior ischemic optic neuropathy (NAAION), 59 eyes of 59 patients with optic neuritis (ON), 677 eyes of 677 patients with open‐angle glaucoma (OAG), and 110 eyes of 110 controls. The patient backgrounds of all groups were compared. Ophthalmologic findings were evaluated, adjusting for age, sex, blood pressure, pulse rate, and underlying systemic diseases with 1:1 optimal propensit

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Takahashi, Nana, Naoki Kiyota, Hiroshi Kunikata, et al. "Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients." BMC Ophthalmology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12886-023-03059-0.

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Abstract Background The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG patients and healthy controls. Methods We performed cold-water provocation in 14 eyes of 14 NTG patients and 15 eyes of 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), skin blood flowmetry-derived pulse wave amplitude (PA), nailfold capillaroscopy-der

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Ning, Yijie, Jie Hu, Haifeng Li, et al. "Case Report: The application of novel imaging technologies in lower extremity peripheral artery disease: NIR-II imaging, OCTA, and LSFG." Frontiers in Cardiovascular Medicine 11 (September 18, 2024). http://dx.doi.org/10.3389/fcvm.2024.1460708.

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Lower extremity peripheral artery disease (PAD) is a growing global health problem. New methods to diagnose PAD have been explored in recent years. At present, the majority of imaging methods for PAD focus on the macrovascular blood flow, and the exploration of microcirculation and tissue perfusion of PAD remains largely insufficient. In this report, we applied three new imaging technologies, i.e., second near-infrared region (NIR-II, 900–1,880 nm wavelengths) imaging, optical coherence tomography angiography (OCTA), and laser speckle flowgraphy (LSFG), in a PAD patient with a healthy human su

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Ebuchi, Yasunari, Taiji Nagaoka, Daisuke Fukamachi, et al. "Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-021-04196-6.

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AbstractThis study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients. We evaluated 53 ACS patients between April 2019 and September 2020. LSFG measured the mean blur rate (MBR) and ocular blowout time (BOT) and resistivity index (RI). 110 consequent patients without a history of coronary artery disease who visited ophthalmology as a control group. Significant positive correlations were observed between ocu

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Hayashi, Naoyuki, Hideaki Kashima, and Tsukasa Ikemura. "Facial Blood Flow Responses to Dynamic Exercise." International Journal of Sports Medicine, September 18, 2020. http://dx.doi.org/10.1055/a-1244-9870.

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AbstractWe reported previously that a static handgrip exercise evoked regional differences in the facial blood flow. The present study examined whether regional differences in facial blood flow are also evoked during dynamic exercise. Facial blood flow was measured by laser speckle flowgraphy during 15 min of cycling exercise at heart rates of 120 bpm, 140 bpm and 160 bpm in 12 subjects. The facial vascular conductance index was calculated from the blood flow and mean arterial pressure. The regional blood flow and conductance index values were determined in the forehead, eyelid, nose, cheek, e

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Pai, Viktoria, Andrea Bileck, Nikolaus Hommer, et al. "Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-56834-4.

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AbstractThe aim of the present study was to investigate retinal microcirculatory and functional metabolic changes in patients after they had recovered from a moderate to severe acute COVID-19 infection. Retinal perfusion was quantified using laser speckle flowgraphy. Oxygen saturation and retinal calibers were assessed with a dynamic vessel analyzer. Arterio-venous ratio (AVR) was calculated based on retinal vessel diameter data. Blood plasma samples underwent mass spectrometry-based multi-omics profiling, including proteomics, metabolomics and eicosadomics. A total of 40 subjects were include

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Lin, Pei‐Wen, Li‐Wen Chiu, Chun‐Tuan Chang, and Hsin‐Ching Lin. "Impaired blood flow of optic nerve head in patients with severe obstructive sleep apnea/hypopnea syndrome." Journal of Sleep Research, November 27, 2024. http://dx.doi.org/10.1111/jsr.14422.

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SummaryThis study prospectively analysed the difference in the blood flow of the optic nerve head (ONH) between patients with obstructive sleep apnea/hypopnea syndrome (OSA) and control subjects by laser speckle flowgraphy (LSFG), and determined the correlations between LSFG variables and the severity of OSA. A total of 100 participants consecutively underwent full‐night polysomnography, ophthalmologic examinations, and LSFG measurements. The LSFG parameters were summarised as the mean blur rate in all areas of the ONH (MA), in the big vessel area of ONH (MV), and in the tissue area of ONH (MT

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von Vopelius-Feldt, Alexander, Timothy Hamann, Andreas Mayr, and Marc Töteberg-Harms. "Evaluation of Reproducibility of Measurements of Peripapillary Blood Flow with Laser Speckle Flowgraphy in Healthy and POAG Subjects." Klinische Monatsblätter für Augenheilkunde, December 18, 2024. https://doi.org/10.1055/a-2469-8403.

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Abstract Background Peripapillary blood flow is of diagnostic value in glaucoma. Material and Methods We investigated the reproducibility of peripapillary blood flow measurements in healthy individuals and in open-angle glaucoma (OAG) patients with the Nidek laser speckle flowgraphy (LSFG)-NAVI system. Blood flow was calculated as the mean of vascular area (MV), mean of tissue area (MT), and mean of overall flow (MA). Intra-rater, inter-session, and inter-rater reproducibility were assessed by determining the intraclass correlation coefficient (ICC) and coefficient of variance (COV). Results T

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Yamamoto, Nobuhiko, Makoto Nakano, Kotaro Nochioka, et al. "Ocular blood flow dynamics following sinus rhythm restoration through catheter ablation: laser speckle flowgraphy in patients with persistent atrial fibrillation." European Heart Journal - Imaging Methods and Practice 2, no. 3 (2024). http://dx.doi.org/10.1093/ehjimp/qyae071.

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Abstract Aims Laser speckle flowgraphy (LSFG) is a well-established tool renowned for its non-invasive and reproducible assessment of ocular blood flow. While rhythm control therapies, such as catheter ablation (CA), have shown promise in enhancing cognitive function in atrial fibrillation (AF) patients, the acute impact of CA on microcirculatory changes, particularly in ocular blood flow, remains a topic of limited understanding. The present study aims to delve into the potential of LSFG in detecting microcirculatory alterations following the restoration of sinus rhythm (SR) through CA in pat

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Giacomo, Calzetti, La Morgia Chiara, Cattaeno Marco, et al. "Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy." April 11, 2022. https://doi.org/10.1167/iovs.63.1.43.

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Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):43. doi: 10.1167/iovs.63.1.43. PMID: 35098304; PMCID: PMC8802032   Abstract <strong>Purpose: </strong>The purpose of this study was to evaluate optic disk perfusion and neural retinal structure in patients with subacute Leber's hereditary optic neuropathy (LHON) and LHON carriers, as compared with healthy controls. <strong>Methods: </strong>This study included 8 patients with LHON in the subacute stage, 10 asymptomatic carriers of a LHON-associated mitochondrial DNA mutation

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Hanaguri, Junya, Harumasa Yokota, Masahisa Watanabe, et al. "Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-97651-3.

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AbstractWe investigated and compared the susceptibility of retinal blood flow regulation and neural function in mice developing type 2 diabetes. The longitudinal changes in retinal neuronal function and blood flow responses to a 10-min systemic hyperoxia and a 3-min flicker stimulation were evaluated every 2 weeks in diabetic db/db mice and nondiabetic controls (db/m) from age 8 to 20 weeks. The retinal blood flow and neural activity were assessed using laser speckle flowgraphy and electroretinography (ERG), respectively. The db/db mice had significantly higher blood glucose levels and body we

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Ueno, Yoshitaka, Takeshi Iwase, Kensuke Goto, et al. "Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-84067-2.

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AbstractWe investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all P < 0.001). However, the external diameter of the retinal vessels was not

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Swiatczak, Barbara, Frank Schaeffel, and Giacomo Calzetti. "Imposed positive defocus changes choroidal blood flow in young human subjects." Graefe's Archive for Clinical and Experimental Ophthalmology, September 29, 2022. http://dx.doi.org/10.1007/s00417-022-05842-z.

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Abstract Purpose It has previously been found that imposing positive defocus changes axial length and choroidal thickness after only 30 min. In the present study, we investigated whether these changes may result from an altered choroidal blood flow. Methods Eighteen young adult subjects watched a movie from a large screen (65 in.) in a dark room at 2 m distance. A 15-min wash-out period was followed by 30 min of watching the movie with a monocular positive defocus (+ 2.5D). Changes in axial length and ocular blood flow were measured before and after the defocus, by using low-coherent interfero

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Lin, Pei-Wen, and Li-Wen Chiu. "Evaluation of optic nerve head microcirculation in open-angle glaucoma patients with unilateral visual field defect." Ophthalmic Research, March 20, 2024. http://dx.doi.org/10.1159/000538407.

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Introduction: Microcirculation of optic nerve head (ONH) in open-angle glaucoma (OAG) patients with unilateral visual field (VF) loss has yet to be fully investigated, especially the perimetrically unaffected fellow eyes. Methods: Thirty-eight OAG patients with VF defect in one eye and normal VF in the other eye, and thirty-one healthy participants were analyzed. All participants underwent laser speckle flowgraphy (LSFG), spectral-domain optical coherence tomography (SD-OCT) imaging, and VF test for further analyses. LSFG measurements included mean blur rate in all area of ONH (MA), big vessel

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Murata, Juri, Miyuki Unekawa, Yuya Kudo, et al. "Acceleration of the Development of Microcirculation Embolism in the Brain due to Capillary Narrowing." Stroke, June 13, 2023. http://dx.doi.org/10.1161/strokeaha.122.042416.

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Background: Cerebral microvascular obstruction is critically involved in recurrent stroke and decreased cerebral blood flow with age. The obstruction must occur in the capillary with a greater resistance to perfusion pressure through the microvascular networks. However, little is known about the relationship between capillary size and embolism formation. This study aimed to determine whether the capillary lumen space contributes to the development of microcirculation embolism. Methods: To spatiotemporally manipulate capillary diameters in vivo, transgenic mice expressing the light-gated cation

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Tornow, Ralf-Peter, Radim Kolar, Jan Odstrcilik, Ivana Labounkova, and Folkert Horn. "Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head." Graefe's Archive for Clinical and Experimental Ophthalmology, September 22, 2020. http://dx.doi.org/10.1007/s00417-020-04934-y.

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Abstract Purpose To measure parameters of the cardiac cycle-induced pulsatile light absorption signal (plethysmography signal) of the optic nerve head (ONH) and to compare parameters between normal subjects and patients with different stages of glaucoma. Patients and methods A recently developed video ophthalmoscope was used to acquire short video sequences (10 s) of the ONH. After image registration and trend correction, the pulsatile changing light absorption at the ONH tissue (excluding large vessels) was calculated. The changing light absorption depends on the pulsatile changing blood volu

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JIN, ZI, ZIXIA ZHOU, BIN ZHANG, et al. "26-LB: Risk Factors of Retinal Oxygen Metabolism and Hemodynamics for Retinopathy in Diabetes." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-26-lb.

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Purpose: Alterations in retinal oxygen metabolism and hemodynamics are signs of impending diabetic retinopathy (DR) . The study aimed to investigate risk factors of the retinal oxygen metabolism and hemodynamics for non-proliferative DR (NPDR) . Method: The study included 166 eyes from 50 age-matched healthy subjects, 80 diabetic patients without DR (Non-DR) , and 36 NPDR. Each subjects underwent basic medical history and dilated fundal examinations including colour fundus photography, and custom-built multimodal ophthalmic device with function of retinal oximetry and laser speckle flowgraphy.

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