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1
Ansari, Saira. "Calcium control of smooth muscle myofilament activity : an integrated dual regulations [i.e regulation system]." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405559.
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Arora, Sumit. "Online regulations of low order systems under bounded control." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/376.
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Time-optimal solutions provide us with the fastest means to regulate a system in presence of input constraints. This advantage of time-optimal control solutions is offset by the fact that their real-time implementation involves computationally intensive iterative techniques. Moreover, time-optimal controls depend on the initial state and have to be recalculated for even the slightest perturbation. Clearly time-optimal controls are not good candidates for online regulation. Consequently, the search for alternatives to time-optimal solutions is a very active area of research. The work described here is inspired by the simplicity of optimal-aim concept. The "optimal-aim strategies" provide online regulation in presence of bounded inputs with minimal computational effort. These are based purely on state-space geometry of the plant and are inherently adaptive in nature. Optimal-aim techniques involve aiming of trajectory derivative (or the state velocity vector) so as to approach the equilibrium state in the best possible manner. This thesis documents the efforts to develop an online regulation algorithm for systems with input constraints. Through a number of hypotheses focussed on trying to reproduce the exact time-optimal solution, the diffculty associated with this task is demonstrated. A modification of optimal-aim concept is employed to develop a novel regulation algorithm. In this algorithm, aim directions are chosen in a special manner to generate the time-optimal control approximately. The control scheme thus developed is shown to be globally stabilizing for systems having eigenvalues in the CLHP (closed left half-plane). It is expected that this method or its modifications can be extended to higher dimensional systems as a part of future research. An alternative control algorithm involving a simple state-space aiming concept is also developed and discussed.
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Tong, González Francisco. "Administrative Simplification and "Positive Regulation" in the Environmental and Mining Regulations." Derecho & Sociedad, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/119160.
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In this article, the author studies the objectives and principles established during the 90’s,with respect to administrative simplification in contrast with the current governmental objectives for the optimization of the economy and reduction of unnecessary procedures,basically related to mining and environmental proceedings. Finally, the author proposes theneed for a structural change in Peruvian Mining and Environmental Regulations under the framework of what he calls a «positive regulation».<br>En el presente artículo el autor reflexiona acerca de los objetivos y principios trazados en la década del noventa, en lo que respecta específicamente a la simplificación administrativa comparándolos con los objetivos actuales de dinamización de la economía y reducción de trámites innecesarios; principalmente, los referidos a procedimientos mineros y ambientales. Finalmente, el autor plantea la necesidad de un cambio estructural en la regulación ambiental y minera bajo la forma de lo que denomina una «regulación positiva».
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Collins, John. "Regulations and prohibitions : Anglo-American relations and international drug control, 1939-1964." Thesis, London School of Economics and Political Science (University of London), 2015. http://etheses.lse.ac.uk/3107/.
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This thesis examines the Anglo-American Relationship around international drug control and addresses two main questions: first, was there a ‘special relationship’ in the field of drug control? Second, what impact did their relationship have on international control efforts? It highlights that the relationship was far from ‘special’ and was frequently strained. Further, it argues that the outcomes of international drug control efforts, between the collapse of the League of Nations system during World War II and the coming into force of the 1961 Single Convention on Narcotic Drugs in 1964, derived from a triangulation of three international drug control blocs: control advocate states, led by the US; producing states and their noninterventionist allies, led by Turkey and the Soviet Union; and moderate manufacturing and consuming countries, led by the UK. In this triangulation process the UK and US remained the lead international actors and represented the two core policy strands within the system: regulation and prohibition respectively. The Anglo-American drug relationship saw overlap and division in policy interests, resulting in both cooperation and competition. They overlapped around pursuing a global regulatory system managing the flows of ‘dangerous drugs’ internationally. They diverged around the peripheral or frontier aspects of this system: namely, where to draw the line between licit and illicit consumption; how tightly to restrict, regulate and prohibit global production; how much national oversight and interference to provide international organisations; and how to deal with existing drug consuming populations. Where their policy interests overlapped, and when the UK and US consciously worked together, international political progress was possible. Where the two diverged, around strict adherence to prohibitionist principles; overly restricting the manufacturing sector’s ability to procure raw materials; and assuming national obligations for a repressive ‘closed institutional’ model of dealing with ‘addiction’, political momentum generally stalled. Finally, this thesis argues that the 1961 Single Convention evolved via Anglo-American ‘competitive cooperation’ and was ultimately a joint Anglo-American creation: a regulatory system with prohibitionist aspects. However, the 1961 Single Convention ultimately represented a victory for the regulatory strand and the UK over the US-led prohibitionist strand.
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Cooper, David. "Nonlinear Tracking by Trajectory Regulation Control using Backstepping Method." Ohio University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1125370268.
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McDougall, Christopher W. "Uncertain risks, responsibilities & regulations : the ethics & control of PGD in Canada." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33915.
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The current state of preimplantation genetic diagnosis technology is presented, as are the biological principles and medical procedures that make it possible. The arguments of both proponents and those with social and ethical reservations about the broader implications of the technique are carefully reviewed, and the limitations of the dominant medical model approach to the technique are exposed. A discussion of reproductive autonomy in light of emerging testing applications of PGD not directly related to the avoidance of serious genetic abnormalities in the resulting child demonstrates the complexity of both clinical decision-making and public policy formulation with regard to PGD. Recently proposed legislation in Canada reflects such complexities, and highlights the lack of social consensus on the appropriate uses of, and restrictions on, PGD. A variety of "soft law" instruments, notably professional codes of practice and research guidelines implemented by institutional ethics committees, may mitigate some of the uncertainty surrounding PGD in Canada, but their limited applicability and espousal of the medical model approach render questionable their capacity to reconcile tolerance of pluralism with respect for human life, diversity, and reproductive autonomy.
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Huang, Huasheng, and 黃華生. "The effects of building regulations control on the design of private residential buildings." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244944.
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Lundin, Johan. "Safety in case of fire : the effect of changing regulations /." Lund : Dept. of Fire Safety Engineering, Faculty of Engineering, Lund University, 2005. http://www.brand.lth.se/bibl/1032.pdf.
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Spears, Kenneth. "Official control of foodstuffs : evaluation of policy, practice and performance in the UK by case study." Thesis, London South Bank University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323894.
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Lawrence, Timothy James. "Devolution and collaboration in the development of environmental regulations." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117560009.
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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 186 p.; also includes graphics. Includes bibliographical references (p. 133-139). Available online via OhioLINK's ETD Center
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Miller, Edward G. Dover Mark W. "An analysis of federal airport and air carrier employee access control, screening, and training regulations /." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA347007.
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Thesis (M.S. in Management) Naval Postgraduate School, March 1998.<br>"March 1998." Thesis advisor(s): David G. Brown, Donald R. Eaton. Includes bibliographical references (p. 95-97). Also available online.
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Miller, Edward G., and Mark W. Dover. "An analysis of federal airport and air carrier employee access control, screening, and training regulations." Thesis, Monterey, California. Naval Postgraduate School, 1998. http://hdl.handle.net/10945/32723.
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Current Federal AviationRegulations concerning civil aviation security are focused on countering the threat of a passenger hijacking a commercial airplane. Current media and government emphasis is focused on a passenger breaching security at an airport in the U.S. and not an employee breaching security. The security of the U.S. air travel industry from terrorist attacks hinges on an effective civil aviation security program. Government and aviation industry officials would greatly benefit from the revision of the current Federal Aviation Regulations concerning civil aviation security to address the issue of terrorism initiated by an employee. This thesis provides a thorough examination of current Federal Aviation Regulations parts 107 and 108 sections concerning airport and air carrier employee access control, screening, and training. Based upon field research of five U.S. airports, the work furthermore analyzes related issues and problems associated with these regulations and generates recommendations that serve to enhance security for the traveling public, air carriers, and persons employed by or conducting business at public airports.
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Mohammed, Zakaria Nehari Talet. "An Analysis of the Determinants of Internal Control Disclosure by Multinational Corporations." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31811.
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Purpose: The objective of this study is to analyze the content of disclosure on internal control in multinational corporations’ annual reports and to investigate the determinants of disclosure. The study questions whether there are differences in the content, volume and quality of disclosure between multinational corporations and what factors could explain these differences?
Methodology: This research is based on 178 multinational corporations selected from the 2012 ranking of Global 500 published by Fortune Magazine. Content analysis was used to analyze the volume and quality of internal control information disclosed in the multinational corporations’ annual reports. The study accommodates for three disclosure measures which are: Disclosure Index (DI), Disclosure Volume (DV) and Disclosure Quality (DQ)
Findings: Based on univariate and multivariate analysis, results seem to indicate that national factors are more significant in explaining the differences in disclosure than governance and operational factors. The study also proved that there is at least one significant variable under each category of factors (National, Governance and Operational)
Implications: These findings could be relevant to a number of stakeholders concerned with multinational corporations’ activities and performances. Stakeholders influenced by the study are top managers of Multinational Corporation, regulatory setters and investors. The research has implications on the accounting literature by shedding light on disclosure on internal control and the internal control factors grouping.
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Чернадчук, Т. О. "Деякі питання щодо визначення предмета валютного права". Thesis, Українська академія банківської справи Національного банку України, 2008. http://essuir.sumdu.edu.ua/handle/123456789/61035.
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У сучасних умовах стало очевидним, що подальший розвиток ринкової
економіки демократичної держави Україна неможливий без адекватного пра-
вового регулювання нових економічних явищ. До таких явищ, які потребують
детального вивчення і правового регулювання, належать валюта і валютні
відносини. У зв’язку з вступом України в СОТ постійно розширюються її зо-
внішньоекономічні зв’язки з країнами близького і далекого зарубіжжя, зрос-
тають обсяги операцій в іноземній валюті, операції з іншими валютними цін-
ностями, виникає потреба у вивченні юристами банків і інших фінансово- кредитних установ валютних правовідносин, валютного права.
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Yeung, Min. "Means to control the traffic problems of the cross harbour tunnel : with focus on traffic management and toll pricing /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19668788.
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Hemphill, Ross C. "Assessing the costs of additional sulfur emissions regulations on the economy of Ohio : the intersectoral impacts of acid rain control /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487588939088903.
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Pelletier, Diane Beatrice. "Identification and partial biological characterization of autocrine growth inhibitory activity in Nb2 lymphoma cell conditioned medium." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185002.
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The purpose of these studies was to determine whether lactogen-dependent Nb2-11c cells and lactogen-independent Nb2-SP cells differ with respect to morphology and autocrine growth control. To this end, the ultrastructural and surface morphology of both Nb2 cell lines was analyzed and the autocrine growth modulatory activity of Nb2 cell conditioned medium (Nb2-CM) was determined. The autocrine growth inhibitory activity of Nb2-CM was biologically characterized and attempts were made to biochemically characterize and purify the Nb2 cell autocrine growth inhibitor as well as to determine its mechanism of action. Quantitative analysis of transmission electron micrographs reveals that the ultrastructural morphology of lactogen-dependent Nb2-11c cells differs from that of lactogen-independent Nb2-SP cells. Nb2-11c cells exhibit a greater incidence and volume density of nuclear pockets, whereas the incidence and volume density of lipid droplets is greater in the Nb2-SP cell line. Surface feature of Nb2-11c and Nb2-SP cells, as examined with scanning electron microscopy, and indistinguishable. Nb2-11c and Nb2-SP cells share a common mode of growth control in the form of constitutive secretion of an autocrine inhibitory factor. Medium conditioned by either Nb2-11c or Nb2-SP cells inhibits the growth of both cell lines. Nb2-CM-mediated growth inhibition is dose-dependent and reversible. Nb2-CM does not induce quiescence or cell death, but rather, causes a delay in the progression of cells through all phases of the cell cycle. Nb2 cell proliferation stimulated by a variety of mitogens is inhibited by Nb2-CM. Nb2-CM also has the ability to inhibit the growth of normal rat splenocytes as well as MCF-7 human breast cancer cells. Biochemical analysis of Nb2-CM was equivocal; however, indirect evidence suggests that the autocrine growth inhibitory factor produced by Nb2 cells may be a prostaglandin or another arachadonic acid metabolite since the growth inhibitory activity of Nb2-CM is reduced when CM is prepared in the presence of indomethacin. Interestingly, levels of prostaglandin F₁(α) are elevated in CM-treated culture supernatants. Examination of other signal transduction systems in Nb2 cells suggests that neither cAMP activation, polyamine biosynthesis, nor protein kinase C activation mediate or influence the inhibitory effect of Nb2-CM.
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Smith, Stefan Thor. "Modelling thermal loads for a non-domestic building stock : associating a priori probability with building form and construction : using building control laws and regulations." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10895/.
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Building Energy Assessment at stock level is an important task in identifying the best strategies for achieving a more energy efficient and low carbon society. Non-domestic buildings are identified to make up 17% of total energy consumption in England and Wales and 19% of CO2 emissions. To understand the energy requirement of the non-domestic stock, large scale (empirically based) energy surveying has been carried out namely in the Non-Domestic Building Stock project and Carbon Reductions in Buildings project. It is recognised that building energy surveys are difficult to carry out; expensive on time, technical resources, and metered energy use is (on a large scale) necessarily crude. With improving computer ability, dynamic energy modelling tools allow for detailed assessment of building energy use and comfort performance. Using Monte Carlo simulation a method of assessing the probable variability in non-domestic building thermal energy loads was developed. The method was developed to capture the heterogeneity in non-domestic buildings at national stock level and determine how stock level physical form variations impact thermal loading. Non-domestic building form and surrounding topography are considered to be influenced by building control laws and building regulations. Control documentation often stipulates guidelines and best practice - hence building heterogeneity. As such, historical regulations were used to develop basic probability distributions of potential physical characteristics associated with non-domestic buildings. Stating that form and site characteristics are randomly determined from the defined probability distributions, a stochastic modelling process to represent thermal variation in a building stock was developed. This provided potential for categorising building thermal performance by period of construction. The model utilised a dynamic simulation model as a 'black-box' for predicting base thermal loads.
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Canholi, Julio Fracarolli. "Medidas de controle \"in situ\" do escoamento superficial em áreas urbanas: análise de aspectos técnicos e legais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/3/3147/tde-10072014-161954/.
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Os novos empreendimentos em construção na Região Metropolitana de São Paulo (RMSP) ao não mitigar os impactos nos sistemas de drenagem repassam seus custos para a sociedade, a qual acaba por pagar grandes quantias em obras que se tornam rapidamente obsoletas devido ao constante aumento da impermeabilização da bacia. Em muitas cidades ao redor mundo, buscou-se contrabalancear os efeitos da urbanização através da implantação de medidas de controle na fonte encorajadas por regulamentações, leis ou decretos. Em muitos casos, a introdução deste tipo de solução levou a resultados adversos, não só devido à escolha do dispositivo, como também devido às normas dispostas nas regulamentações existentes. Foi realizado um estudo de caso para um grande empreendimento da RMSP, utilizando o software SWMM. O estudo avaliou quatro diferentes cenários de ocupação com análise do desempenho tanto na fonte quanto na bacia do empreendimento e na bacia de ordem superior. Entre os cenários incluíram-se situações com a instalação de microrreservatórios e jardins de chuva. Os resultados mostraram que, utilizando a lei das piscininhas aplicável ao município e ao estado de São Paulo (Lei municipal 41.814/02 e Lei estadual 12.526/07), foi possível abater o pico de cheia em 20% nas áreas diretamente controladas, e entre 11% e 9% no empreendimento e sua bacia. Na bacia de ordem superior foi observado uma piora em 0,4% no pico. Alterando a localização dos microrreservatórios foi possível dobrar sua eficácia. Os resultados para os jardins de chuva foram piores para os eventos pouco frequentes, porém, estes dispositivos conseguem diminuir em 64% o número de eventos com geração de escoamento superficial para as áreas controladas, eventos ligados fortemente à qualidade das águas. Concluiu-se que a lei vigente hoje na RMSP atende apenas parcialmente seu objetivo de controle de cheias. Considerando que essa lei apresenta boa oportunidade para aumentar a eficácia do sistema de drenagem, seu conteúdo deve ser revisto, à luz dos resultados obtidos nesta pesquisa. Além disso, é uma lei que permite controlar a poluição difusa, fator de degradação dos rios urbanos.<br>New urban developments may cause serious inconvenience on urban drainage systems when their hydrologic impacts are not properly mitigated. Many cities around the world tried to minimize the effects of urbanization by implementing source control measures encouraged by regulations, laws or ordinances. In many cases, the introduction of this type of solution has led to adverse outcomes, not only because of the choice of the device, but also due to regulations control standards. This study evaluated four different urbanization scenarios in order to analyze São Paulo´s ordinance efficacy on controlling hydrologic impacts of new developments. Among these scenarios, the installation of micro reservoir and rain gardens were evaluated. Results showed that it would possible to attenuate peak flows from source controlled areas by 20%., and by 11% and 9% considering the contribution from the whole development of the catchment, respectively. When the location of the micro reservoir was changed, it was possible to double the attenuation efficacy. The use of rain gardens showed worse results for peak flow attenuation. However, these devices can reduce by 64% the number of runoff events from controlled areas, which are strongly linked to water quality. It was concluded that the existing law (municipal law 41.814/02 and state law 12.526/07) only partially meets its goal for flood control. The law presents a good opportunity to increase the effectiveness of urban drainage systems and its contents should be revised in order to allow non point source pollution control and urban river degradation.
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Dostálová, Milena. "Kontrola kvality v auditorské společnosti." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-10493.
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Thesis deals with the quality control of audit firms in accordance with international regulations. Defining the requirements for quality based on the Code of Ethics and the International quality standard ISQC1. Part of this work is the practical demonstration of ISQC1 in the smaller audit firm. For comparison, there is a description of quality control in the U.S.
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Yeung, Min, and 楊勉. "Means to control the traffic problems of the cross harbour tunnel: with focus on traffic management and tollpricing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31951132.
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Schultz, Anthon, and Tomas Shaw. "Conversion of buildings to student housing in Stockholm – A supplement to solve the lack of student homes?" Thesis, KTH, Fastigheter och byggande, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147659.
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Stockholm is today one of the fastest growing regions in Europe and the demand for housing is increasing by the day. In order to achieve the target of becoming Europe's most attractive metropolitan region the city needs highly educated and skilled labour to satisfy the demand of companies today and in the future. However, the housing situation for students in the Stockholm area is at the moment very bleak. Stockholm is at least 7,000 student housings short and the quetime reaches as high as two years. Despite the lack of housing for students, we can’t see any increase in construction. This means that the students have a difficult time finding somewhere to live which results in that they choose to study elsewhere. In 2009 Boverket said that we must examine alternative solutions for resolving shortage of housing for students. In recent years a couple of projects can be seen in which existing buildings have converted its use from office or shops to student housing. An investigation of how the market views this option has been lacking. This essay aims to examine the student housing market in Stockholm in order to investigate whether conversion of existing buildings is an effective supplement when construction of new housing can’t meet the demand. We have furthermore examined a couple of restraining factors, in order to make the process more effective and finished of by drawing a couple of conclusions. The current planning process is considered to be one of the most restraining factors that leads to the fact that conversion can’t be utilized to its full extent. Lead times are said to be long and the fact that the plan is to detailed and precise makes it difficult to convert properties. With the help of more administrators and a more open plan, conversion could be used to its full extent. Building regulations are considered to be another reason why so few projects are being converted. The same rules apply when you build new buildings as when you convert. The market is looking for a change in the presentation of the current rules in order for these to be more applicable and beneficial for the market. Unpredicted expenses are always a risk when converting but with more experience the risk becomes lower. A system where you subsidize a part is not a market request since a lot of the answers suggest that this affects a market negatively in the long run. Rent control is not a factor that is considered to be restraining when converting buildings for student housing.<br>Stockholm är idag en av de snabbast växande regionerna i Europa och efterfrågan på bostäder i staden blir allt större för varje dag. För att uppnå de mål som finns om att bli Europas mest attraktiva storstadsregion behövs kompetent arbetskraft till staden för att fylla det behov som företagen efterfrågar nu och i framtiden. Den bostadssituation som råder för studenterna i Stockholmsområdet är dock väldigt dyster. Det saknas i dagsläget minst 7000 studentbostäder och kötiden för en studentbostad uppgår i dagsläget till minst två år. Trots detta ser vi inte någon större ökning av nyproducerade studentbostäder. När studenterna har svårt att hitta bostäder tenderar dessa att studera på annan ort och kunskap förloras, vilket hämmar Stockholms utveckling. Boverket kom 2009 med åsikten att man måste utreda alternativa lösningar för att lösa bostadsbristen för studenter. På senare år har man kunnat se projekt där befintliga fastigheter konverterats och ändrat användning från lokaler till studentbostäder. En utredning kring hur marknaden ser på detta alternativ har saknats. Denna rapport syftar till att studera studentbostadsmarknaden i Stockholm för att undersöka om konvertering av befintliga fastigheter är ett slagkraftigt komplement när nyproduktionen inte når upp till de mål som eftersöks. Genom att uppmärksamma ett antal återhållande faktorer har vi kunnat komma fram till ett antal slutsatser. Dagens system för planprocessen anses vara en faktor som gör att detta komplement inte kan utnyttjas till sin fulla grad. Ledtiderna uppges vara för långa och detaljplanens precisa och detaljerade utformning försvårar möjligheten att konvertera fastigheter. Med hjälp av fler handläggare och en mer öppen plan skulle detta komplement kunna tillämpas till sin fulla grad. Byggregler som tillämpas anses vara en annan anledning till att färre projekt genomförs. Samma byggregler som tillämpas för nyproduktion eftersträvas även vid konvertering. Marknaden söker en ändring av utformningen på dagens regler för att dessa ska vara mer tillämpbara och nyttiga för marknaden. Oförutsedda kostnader är en risk som alltid kommer vara ett orosmoln vid konverteringsprojekt men desto mer erfarenhet aktörerna har desto mindre blir risken. Subventionssystem är inte något som eftersträvas då resultatet pekar på att bidrag och investeringsstöd påverkar en marknad negativt i det långa loppet. Att hyresreglering för bostäder existerar anses inte vara en återhållande faktor för att detta komplement ska bli slagkraftigt
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Ahmed, Hassan Ahmed Osama. "Rift Valley fever : challenges and new insights for prevention and control using the “One Health” approach." Doctoral thesis, Umeå universitet, Virologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127095.
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Rift Valley fever (RVF) is an emerging viral zoonosis that causes frequent outbreaks in east Africa and on the Arabian Peninsula. The likelihood of RVF global expansion due to climate change and human anthropogenic factors is an important issue. The causative agent, RVF virus, is an arbovirus that is transmitted by several mosquito species and is able to infect a wide range of livestock as well as people. The infection leads to mass abortions and death in livestock and a potentially deadly hemorrhagic fever in humans. RVF has severe socio-economic consequences such as animal trade bans between countries, disruption of food security, and economic disaster for farmers and pastoralists as well as for countries. Human behavior such as direct contact with infected animals or their fluids and exposure to mosquito bites increases the risk for contracting the disease. To better understand the challenges associated with RVF outbreaks and to explore prevention and control strategies, we used the One Health approach. The local community had to be involved to understand the interaction between the environment, animals, and humans. We focused on Sudan, Saudi Arabia, and Kenya. First, we systematically reviewed the literature and then we performed cross sectional community-based studies using a special One Health questionnaire. Climatic and remote sensing data were used in combination with statistics to develop a sub-region predictive model for RVF. For both Saudi Arabia and Sudan, the ecology and environment of the affected areas were similar. These areas included irrigation canals and excessive rains that provide an attractive habitat for mosquito vectors to multiply. The surveillance systems were unable to detect the virus in livestock before it spread to humans. Ideally, livestock should serve as sentinels to prevent loss of human lives, but the situation here was reversed. Differences between countries regarding further spread of RVF was mainly determined by better economic and infrastructure resources. In Sudan, there was a lack of knowledge and appropriate practices at the studied community regarding RVF disease symptoms and risk factors for both animals and humans. The community was hesitant in notifying the authorities about RVF suspicion in livestock due to the lack of a compensation system. The perceived role of the community in controlling RVF was fragmented, increasing the probability of RVF transmission and disease. In Kenya, our study found that better knowledge about RVF does not always translate to more appropriate practices that avoid exposure to the disease. However, the combination of good knowledge, attitudes, and practices may explain why certain communities were less affected. Strategies to combat RVF should consider socio-cultural and behavioral differences among communities. We also noticed that RVF outbreaks in Kenya occurred in regions with high livestock density exposed to heavy rains and wet soil fluxes, which could be measured by evapotranspiration and vegetation seasonality variables. We developed a RVF risk map on a sub-regional scale. Future outbreaks could be better managed if such relevant RVF variables are integrated into early warning systems. To confront RVF outbreaks, a policy is needed that better incorporates ecological factors and human interactions with livestock and environment that help the RVF pathogen spread. Early detection and notification of RVF is essential because a delay will threaten the core of International Health Regulations (IHR), which emphasizes the share of information during a transboundary disease outbreak to avoid unnecessary geographical expansion.
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Панченко, Вадим Федорович, та Наталія Анатоліївна Орленко. "Влияние учета медико-биологических показателей при разработке нормативов физической подготовленности". Thesis, Российский государственный профессионально-педагогический университет, 2017. http://er.nau.edu.ua/handle/NAU/26220.
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В статье указано на необходимость внесения изменений в нормативно-правовое обеспечение Украины в части создания единой государственной методики для разработки научно обоснованных норм к контрольным упражнениям для определения уровня физической подготовленности разных слоёв населения. Обоснованы безотлагательные первоочередные задачи качественного обеспечения проведения тестирования населения. Предложено пути для создания эффективной системы подготовки нормативов контрольных упражнений для тестирования физической подготовленности разных слоёв населения.<br>The article pointed to the need for changes in the regulatory and legal support for Ukraine in terms of creating a unified state methodology for the development of science-based standards to control exercise to determine the level of physical preparedness of different strata of the population. Substantiated urgent priorities to ensure quality testing of the population. Proposed ways to create an effective system of training exercises control standards for testing physical fitness of the different layers of the population.
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Орленко, Наталія Анатоліївна, та Вадим Федорович Панченко. "Влияние учета медико-биологических показателей при разработке нормативов физической подготовленности". Thesis, Российский государственный профессионально-педагогический университет, 2017. http://er.nau.edu.ua/handle/NAU/26202.
Full textAbstract:
В статье указано на необходимость внесения изменений в нормативно-правовое обеспечение Украины в части создания единой государственной методики для разработки научно обоснованных норм к контрольным упражнениям для определения уровня физической подготовленности разных слоёв населения. Обоснованы безотлагательные первоочередные задачи качественного обеспечения проведения тестирования населения. Предложено пути для создания эффективной системы подготовки нормативов контрольных упражнений для тестирования физической подготовленности разных слоёв населения.<br>The article pointed to the need for changes in the regulatory and legal support for Ukraine in terms of creating a unified state methodology for the development of science-based standards to control exercise to determine the level of physical preparedness of different strata of the population. Substantiated urgent priorities to ensure quality testing of the population. Proposed ways to create an effective system of training exercises control standards for testing physical fitness of the different layers of the population.
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Hentschel, Eva. "Enforcing Pollution Control Regulation /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487929745336057.
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Peters, Alister Michael. "Pharmacological regulators of T cell calcium stores." Scholarly Commons, 2004. https://scholarlycommons.pacific.edu/uop_etds/596.
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Calcium is a crucial intracellular messenger controlling a plethora of important intracellular events. Elevated [Ca2+]i levels regulate numerous processes due to the versatility of the Ca2+ signaling in terms of speed, amplitude and spatia-temporal patterning. Depletion of intracellular calcium stores functions as a primary trigger for a message that is translated to the plasma membrane, resulting in the slow activation of plasma membrane Ca2+ influx channels, which allow entry of external calcium. Since these channels depend upon the state of filling of the intracellular Ca2+stores, these influx channels are called store-operated channels (SOCs). It is unclear how empty intracellular stores signal activation of plasma membrane capacitative calcium entry (CCE). In order to bridge the gaps in our understanding of calcium's role in T cell regulation, this project was designed to look at the effects of various pharmacological regulators of T cell calcium stores. At the start, the effort was directed at the regulation of the microsomal calcium A TPases, considering these are perhaps the most essential mediators of intracellular calcium storage. Thapsigargin (TG) and cyclopiazonic acid (CPA) were shown to be the most potent inhibitors of the Ca2+ -ATPase, also a new Ca2+ regulator aaptamine was shown to exert more modest inhibition of the Ca2+ pump. We also characterized a novel compound, gingerol, findings its actions are to stimulate Ca2+ pumps. Cell growth assays revealed an important role for ryanodine receptors (RyRs) in regulating T cell growth. RyR activators CMC and PCB95 dramatically altered T cell growth patterns leading to significantly reduced cell viability. In contrast RyR antagonist dantrolene appeared to induce growth arrest in that cell proliferation was curtailed, yet cells remained viable.
Cell viability studies revealed that the Ca2+ pump regulators TG and aaptamine were also observed to reduce cell growth rates, presumably as a result of their ability to deplete Ca2+ stores (100 nM TG was able to decrease cell viability by 90% within 24 hrs of exposure). PCB95 was able to decrease cell viability by 50% within 24 of hrs exposure and CMC decreased cell viability by 75% within 24 hrs and further over a 48 hr period. 2-APB and aaptamine were cytotoxic at higher doses. The inositol 1 ,4,5 -trisphosphate receptor (IP3R) pathway was also found to be critically linked to T cell growth control. We observed that the IP3R modulator, 2- aminoethoxydiphenyl borate (2-APB) induced antigen-like Ca2+ spike that correlates with suppression of T cell growth rates.
In this study we have identified two novel T cell Ca2+ store regulators, aaptamine and gingerol. We also find that Ca2+ stores are indeed sensitively linked to T cell growth regulation. Depletion of Ca2+ stores with SERCA inhibitors as well as both RyR and IP3R activators profoundly suppress T cell proliferation most likely via activation of apoptosis.
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Ng, Kwai Choi Stanley. "Regulation strategies for process control." Thesis, University of Sunderland, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337287.
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Koers, Greetje. "Brain control of heart regulation." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1997. http://irs.ub.rug.nl/ppn/15779685X.
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Leslie, Daniel A. "Anti-cyberlaundering regulation and control." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2346_1362391049.
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<p>This paper is inspired by the ills borne out of the internet. The internet has become a modern day tool for criminals seeking to conceal the proceeds derived from their crime, hence the <br>problematic notion of cyberlaundering. This paper journeys through the world of cyberlaundering by looking into the structure of the crime in great depth. It explores various possibilities, and tries to hatch out viable solutions to the dilemma.</p>
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Welsman, Sandra June. "Laws regulating business facilitation, control, or overload?: a consideration of Australian business regulation in the early 1990s." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/28066.
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This thesis examines interactions of business, government and the judiciary in Australia through regulatory law. This arena of policy, lawmaking and regulatory practice is explored from a number of integrated perspectives, to a depth not pursued in general reviews.
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Guers, Constance. "Analyse de la régulation de la sécurité : le cas d’un chantier de construction." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEM072.
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À partir de l’analyse des relations interentreprises dans le secteur du bâtiment, cette thèse interroge les difficultés de coopération et de création de règles communes sur un chantier de construction.Ce travail porte sur un sujet important, au regard à la fois du poids économique de l’objet de recherche empirique et des enjeux contemporains du travail en réseau, du recours à la sous-traitance et à des travailleurs détachés. Cette thèse propose une lecture originale de la sécurité au travail, en déplaçant le regard de la conception duale de la sécurité réglée et gérée vers un processus de sécurisation des actions. Son principal apport est de montrer ce qu’est « agir en sécurité » : il ne s’agit pas seulement d’appliquer des procédures affichées ou de respecter des règles mises en action mais surtout de régulation entre une pluralité de sources normatives.Ce travail s’appuie sur la théorie de la régulation sociale. Initialement conçus pour analyser des organisations de type taylorienne, ces outils conceptuels se sont révélés pertinents pour étudier des organisations en réseau de sous-traitance. Ainsi, nous avons décrit les relations de travail, en particulier la sous-traitance et la cotraitance et les effets de ces relations sur la coopération au travail en matière de sécurité. L’objectif est de proposer une réflexion sur les transformations de l’organisation des régulations de la sécurité du et au travail et sur la place de la sous-traitance dans ce processus. Autrement dit, c’est uneréflexion sur la forme des liens sociaux qui participent à la sécurité, à l’action collective en situation de travail en réseaux<br>This thesis addresses the difficulties of cooperation and the elaboration of common rules between multiple firms that work on a same construction yard.This work focuses on an important topic, considering both the economic approach brought by of the empirical research subject and the contemporary issues with network firms, outsourcing organizations and posted workers.This thesis proposes an original approach of workplace safety, by shifting the focus from the dual concept of regulated and managed security to a process of safety control actions.The main contribution of this study concerns the process of "acting safe": which is not only about applying and creating procedures or rules but also about control between a set of normative bodies. This thesis relies on the theory of social regulation and control. This theory was originally built to analyze Taylorist-type organizations, and it has proved its effectiveness in studyingnetworked outsourcing organizations. These conceptual tools have proved to be relevant for studying network firms and outsourcing organizations.Thus, we have described the work coordination and cooperation, between firms that are related with subcontracting and co-contracting commitment. The target is to evaluate safety.The purpose is to propose a system thinking approach of safety control at work within a set outsourcing company.In other words, this study aims to describe forms of social links that contribute to safety at a workplace
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Ainscow, Edward Keith. "Control and regulation of hepatocyte metabolism." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624775.
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Dodd, Jessica Amen Alexandra Fineman Stephanie. "Mechanisms of self-regulation associations between cognitive control and emotion regulation /." Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1427.
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Aasa, Johan. "Linear-Quadratic Regulation of ComputerRoom Air Conditioners." Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-71031.
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Data centers operations are notoriously energy-hungry, with the computing and cooling infrastructures drawing comparable amount of electrical power to operate. A direction to improve their efciency is to optimizethe cooling, in the sense of implementing cooling infrastructures controlschemes that avoid performing over-cooling of the servers.Towards this direction, this work investigates minimum cost linearquadratic control strategies for the problem of managing air cooled datacenters. We derive a physical and a black box model for a general datacenter, identify this model from real data, and then derive, present andtest in the eld a model based Linear-Quadratic Regulator (LQR) strategy that sets the optimal coolant temperature for each individual coolingunit. To validate the approach we compare the eld tests from the LQR strategy against classical Proportional-Integral-Derivative (PID) controlstrategies, and show through our experiments that it is possible to reducethe energy consumption with respect to the existing practices by severalpoints percent without harming the servers within the data center fromthermal perspectives.
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Zhang, Zhen. "Adaptive robust periodic output regulation." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187118803.
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Ndembe, Elvis Mokake. "Offsetting Behavior and the Benefits of Food Safety Policies in Vegetable Preparation and Consumption." Thesis, North Dakota State University, 2007. https://hdl.handle.net/10365/29801.
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Foodbome disease outbreaks have a tremendous impact on society, including foodbome illnesses, hospitalizations, lost work time, and deaths. These food-safety events have a significant influence in shaping consumers' perception of risk. Outbreaks of foodbome illnesses also have an effect on the development of public health policy. Due to these safety-related uncertainties in the food supply chain, various regulatory, safety, and health policies are implemented to decrease harm to potential victims. The total effect of such food-safety policies looked at in terms of reduction of foodbome illness, mortality, and food-related diseases may possibly be smaller than the forecasted effect because of failure to consider offsetting behavior. Attenuation and possibly reversal of the direct policy effect on expected injuries may arise because of offsetting behavior. This study combines both theoretical and empirical models to test the presence of dominant or partial offsetting behavior (OB) in the preparation and consumption of vegetables if a food-safety policy such as the Pathogen Reduction/Hazard Analysis and Critical Control Point (PR/HACCP) is mandated in the vegetable sector. Our findings indicate that food-safety information that has an effect on outrage and locus of control, both factors which have an effect on consumers' perception of risk, will lead consumers to become lax in response to this food-safety policy.
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Arrieta, Orozco Orlando. "PID Control. Servo/regulation performance and robustness issues." Doctoral thesis, Universitat Autònoma de Barcelona, 2010. http://hdl.handle.net/10803/32028.
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Cornock, Marc. "Regulation and control of health care professionals." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54775/.
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This thesis is concerned with the regulation and control of health care professionals. In particular it examines the current regulation to which health care professionals are subject. The hypothesis put forward by this thesis is that the regulation of health care professionals is not fit for purpose. Fit for purpose being defined as satisfying the need for public protection and patient safety, its primary aim, but also enabling to the health care professional by allowing them autonomy to undertake their practice. In examining its hypothesis, the thesis provides an analysis of the nature of a health care professional as well as determining the context within which health care professionals undertake their professional practice. The regulation of health care professionals is analysed through a framework of five elements of regulation that are considered necessary for regulation to achieve its primary aim. These five elements are: protection of titles and registration education for initial registration clinical competence standards for performance and, fitness to practise. Consideration is given to proposals for reform of the regulation of health care professionals, that are yet to be introduced. The thesis finds that some of the elements of regulation are individually fit for purpose but that the current regulation of health care professionals is not fit for purpose as a whole. Recommendations are put forward to improve the effectiveness of regulation. The scope of this thesis is limited to that of health care within England.
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Christie, Christopher Robert. "Calcium/Phosphate Regulation: A Control Engineering Approach." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54014.
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Calcium (Ca) homeostasis is the maintenance of a stable plasma Ca concentration in the human body in the presence of Ca variability in the physiological environment (e.g. by ingestion and/or excretion). For normal physiological function, the total plasma Ca concentration must be maintained within a very narrow range (2.2-2.4mM). Meeting such stringent requirements is the task of a regulatory system that employs parathyroid hormone (PTH) and calcitriol (CTL) to regulate Ca flux between the plasma and the kidneys, intestines and bones. On the other hand, plasma phosphate control is less tightly, but simultaneously, regulated via the same hormonal actions. Chronic imbalances in plasma Ca levels are associated with disorders of the regulatory organs, which cause abnormal hormonal secretion and activity. These changes in hormonal activity may lead to long-term problems, such as, osteoporosis (increased loss of bone mineral density), which arises from primary hyperparathyroidism (PHPT) – hyper secretion of PTH.
Existing in silico models of Ca homeostasis in humans are often cast in the form of a single monolithic system of differential equations and are not easily amenable to the sort of tractable quantitative analysis from which one can acquire useful fundamental insight. In this research, the regulatory systems of plasma Ca and plasma phosphate are represented as an engineering control system where the physiological sub-processes are mapped onto corresponding block components (sensor, controller, actuator and process) and underlying mechanisms are represented by differential equations. Following validation of the overall model, Ca-related pathologies are successfully simulated through induced defects in the control system components.
A systematic approach is used to differentiate PHPT from other diseases with similar pathophysiologies based on the unique hormone/ion responses to short-term Ca disturbance in each pathology model. Additionally, based on the changes in intrinsic parameters associated with PTG behavior, the extent of PHPT progression can be predicted and the enlarged gland size estimated a priori.
Finally, process systems engineering methods are used to explore therapeutic intervention in two Ca-related pathologies: Primary (PHPT) and Secondary (SHPT) Hyperparathyroidism. Through parametric sensitivity analysis and parameter space exploration, the calcium-sensing receptor (sensor) is identified as a target site in both diseases and the extent of potential improvement is determined across the spectrum of severity of PHPT. The findings are validated against existing drug therapy, leading to a method of predicting drug dosage for a given stage of PHPT. Model Predictive Control is used in drug therapy in SHPT to customize the drug dosage for individual patients given the desired PTH outcome, and drug administration constraints.<br>Ph. D.
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PORRU, MARCELLA. "Quality regulation and energy saving through control and monitoring techniques for industrial multicomponent distillation columns." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266573.
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This Thesis deals with the problem of the quality control and monitoring
and the related energy consuming aspects in industrial multicomponent
distillation columns. These have important relevance especially in case of
units subjected to important changes in operating conditions which
manifests in fluctuation of the product concentration.
Due to the low reliability of the seldom available and delayed analytic
composition measurements, they cannot be employed for an efficient
online monitoring of the separation. Instead, this Thesis proposes the use
of composition observers with passive innovation mechanism and driven
by temperature measurements. The passive structure allows to limit the
number of ODEs to be online integrated, which is a central issue to obtain
a product suitable for the industrial implementation. The design of this
passive structure involves the choice of number and location of the
temperature sensors, the choice of the innovated component and the set of
modeled components in the (possibly simplified) estimation model. This
issue is addressed with a simple and systematic methodology that employs
steady state information about the per-component temperature gradient of
the column and detectability measures and conditions. Differently from
the majority of the works in literature, the proposed methodology allows
also to assess the feasibility of obtaining good estimation performance
using the available temperature sensors in real columns.
Even the analytic composition measurements cannot be employed for
quality control in feedback control loops mainly due to delay problems.
Instead, temperature feedback controllers are usually used. But even if the
temperature sensor is well located (and in this Thesis a criterion for sensor
location is suggested based on an extension of the slope criterion to the
multicomponent case), when the operating conditions undergo changes,
the indirect regulation of the product quality cannot be achieved, with
alternating periods of under and over-purification that also adversely
affect the energy requirement for the column functioning. Thus, in this Thesis an application oriented solution is proposed consisting in adding a
feedforward temperature setpoint compensation that guarantee a close
quality regulation, including a more efficient management of the energy,
under the changing operating modes of the column.
The methodologies and techniques proposed and described in this Thesis
are tested with an industrial multicomponent IC4-NC4 splitter located at
the Sarlux Refinery (Sarroch, Italy), which, motivated by the good results,
has already implemented the composition estimator and is going to
implement the feedforward setpoint compensator.
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Cooper, David Maurice. "Nonlinear tracking by trajectory regulation control using backstepping method." Ohio : Ohio University, 2005. http://www.ohiolink.edu/etd/view.cgi?ohiou1125370268.
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Baros, Stefanos. "Distributed Control for Wind Farm Power Output Stabilization and Regulation." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/721.
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Modern power systems are characterized by an increasing penetration of renewable energy generating units. These aim to reduce the carbon emissions in the environment by replacing conventional energy generating units which rely on fossil fuels. In this new power systems composition, wind generators (WGs) dominate, being one of the largest and fastest-growing sources of renewable energy production. Nevertheless, their unpredictable and highly volatile power output hinders their efficient and secure large-scale deployment, and poses challenges for the transient stability of power systems. Given that, we identify two challenges in the operation of modern power systems: rendering WGs capable of reguating their power output while securing transient stabilization of conventional synchronous generators (SGs). This dissertation makes several contributions for effectively dealing with these major challenges by introducing new distributed control techniques for SGs, storage devices and state-of-the-art (SoA) WGs. Initially, this dissertation introduces a novel nonlinear control design which is able to coordinate a storage device and a SG to attain transient stabilization and concurrent voltage regulation on their terminal bus. Thereafter, it proposes control designs that SoA WGs can adopt to effectively regulate their power out- put to meet local or group objectives. In this context, the rst control design is a decentralized nonlinear energy-based control design, that can be employed by a wind double-fed induction generator (DFIG) with an incorporated energy storage device (namely a SoA WG) to regulate its power output by harnessing stored energy, with guaranteed performance for a wide-range of operating conditions. Recognizing that, today, albeit wind farms (WFs) are comprised of numerous WGs which are sparsely located in large geographical areas, they are required to respond rapidly and provide services to the grid in an efficient, reliable and timely fashion. To this end, this dissertation proposes distributed control methods for power output regulation of WFs comprised of SoA WGs. In particular, a novel distributed control design is proposed, which can be adopted by SoA WGs to continuously, dynamically and distributively self-organize and control their power outputs by leveraging limited peer-to-peer communication. By employing the proposed control design, WGs can exploit their storage devices in a fair load-sharing manner so that their total power output tracks a total power reference under highly dynamical conditions. Finally, this dissertation proposes a distributed control design for wind DFIGs without a storage device, the most common type of WGs deployed today. With this control design, wind DFIGs can dynamically, distributively and fairly self-dispatch and adjust the power they extract from the wind for the purpose of their total power tracking a dynamic reference. The effectiveness of the control designs proposed in this dissertation is illustrated through several case studies on a 3-bus power system and the IEEE 24-bus Reliability Test System.
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Calderone, Vittorio. "Regulation of angiogenesis by CPEB-mediated translational control." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/120702.
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Hepatic cirrhosis is a largely diffused pathology caused by alcohol abuse and hepatitis C in developed countries, whereas hepatitis B is the cause in most parts of Asia and sub-Saharan Africa. It's characterized by development of regenerative nodules delimited by fibrous septa. Regenerative nodules are composed by proliferating hepatocytes, entrapped by deposition of extracellular matrix, and have been shown to be involved in growth factor production, in particular VEGF, which is responsible of angiogenic induction that culminates with formation of a dense network of blood vessels into fibrous septa. The newly formed blood vessels of fibrous septa connect the vessels of the portal region with terminal hepatic veins, determining an alternative route of the blood flow that, in this way, is redirected into the systemic circulation bypassing the liver. At pre-hepatic level, the cirrhosisrelated portal hypertension induces development of new blood vessels that shunt the portal blood into the systemic circulation. As consequence of both intrahepatic and pre-hepatic angiogenesis, the liver cannot metabolize several blood components such as drugs, nutrients, toxins, and bacteria, with obvious deleterious effects. Despite angiogenesis is one of the main complications of liver cirrhosis and VEGF has a pivotal role in the control of blood vessels formation, the molecular mechanisms that govern VEGF expression during angiogenesis and hepatic cirrhosis are poorly understood. In order to address whether CPEB family of proteins may have a function in the regulation of angiogenesis in liver diseases, we analysed the expression of CPEBl and CPEB4 in liver of patients affected by hepatic cirrhosis. The expression of CPEBl and CPEB4 was increased in regenerative nodules, compared with basal levels of expression detected in healthy hepatic parenchyma. Interestingly, also VEGF expression was higher in regenerative nodules. The numerous fibrous septa that characterized cirrhotic livers resulted highly vascularized, and the endothelium of newly formed blood vessels expressed high levels of CPEB1, CPEB4 and VEGF. The description of CPEB1, CPEB4 and VEGF expression in healthy and cirrhotic conditions represented a first cue of CPEB-mediated translational regulation of VEGF mRNA during angiogenesis. To prove the accuracy of this hypothesis we implemented two animal models that allowed the study of intrahepatic and prehepatic angiogenesis correlated with liver cirrhosis. CBDL experiments performed in rats enabled to recapitulate the histopathological conditions observed in human hepatic cirrhosis. Cirrhotic rat livers showed deep histological perturbations, with high proliferation of blood vessels and biliary ducts. Compared with control healthy samples, the expression of CPEB1, CPEB4 and VEGF in pathological liver was strongly increased. These proteins localized at level of both, blood vessels and biliary ducts. Partial portal vein ligation (PPVL) experiments performed in rats enabled to show an important correlation between CPEBl and CPEB4 expression with VEGF synthesis and consequent high vascularization of mesentery. In angiogenic condition, both pre-existing and newly formed blood vessels expressed CPEB1, CPEB4 and VEGF at level of endothelium, smooth muscle and adventitia, tissues that playa pivotal role in the development of the vascular net. To better define the mechanistic relevance of these correlations, we characterized the endothelial cell line HSV. In this in vitro model we modulated the levels of CPEBl and CPEB4, and showed a direct involvement of this two proteins in the translational regulation of VEGF mRNA. Taking advance of the ability of HSV cells to form blood vessel like structure in an in vitro angiogenesis assay, we were able to show that CPEBl and CPEB4 are required for VEGF synthesis and secretion, which in turn are essential to create the correct microenvironment necessary to activate the cells and induce the formation of a dense network of vascular structures on Matrigel. Our results suggest that CPEBl drives the nuclear cleavage of VEGF 3'UTR while CPEB4 is responsible of its cytoplasmic polyadenylation.<br>"Regulación de la angiogénesis a través del control traduccional mediato par las proteínas CPEB "
En muchas enfermedades hepáticas cr6nicas, la angiogénesis es una importante característica patológica y juega un papel crucial en la progresión de la fibrogénesis hepática a cirrosis, y en la aparición y agravamiento de la hipertensión portal, la cual determina las principales complicaciones de la enfermedad. A pesar de que es evidente que VEGF es el principal efector de la angiogénesis patológica, los mecanismos moleculares que gobiernan la activación post-transcripcional de su síntesis durante la cirrosis hepática son en gran parte desconocidos. En este trabajo se muestra que la síntesis de VEGF está regulada a través de funciones secuenciales y no redundantes de dos miembros de la familia de las proteínas CPEB:. CPEB1 y CPEB4. Por 10 tanto, CPEB1 promueve el procesamiento alternativo de ambos los pre-ARNm de CPEB4 y VEGF, acortando las 3'UTRs y excluyendo elementos de inhibición de la traducción de los transcritos maduros. Como resultado de este procesamiento alternativo, CPEB4 se sobreexpresa, y polyadenyla el ARNm de VEGF, aumentando aún más su traducción. Entonces, se requieren tanto CPEB1 como CPEB4 para la síntesis de VEGF y la consecuente angiogénesis. Por tanto, todas las proteínas se sobreexpresan de forma secuencial en pacientes y en modelos animales de cirrosis hepática e hipertensión portal, y ambos ratones knock-out para CPEB1 y CPEB4 no lograron activar la angiogénesis tras la inducción de hipertensión portal. A través del análisis de la angiogénesis en ensayos in vitro, las muestras de humanos y modelos animales, nuestros resultados ponen de relieve el papel crucial de CPEBs en la neovascularización patol6gica, en el marco de la hipertensión portal y cirrosis, e identifican CPEBs como potenciales nuevas dianas moleculares para el tratamiento de la enfermedad hepática cr6nica y otras enfermedades dependientes de la neovascularización, como el cáncer.
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Osbourn, Mark Christopher. "The application of microelectronic control to pressure regulation." Thesis, University of Salford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.480870.
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Castro, Beatriz. "Access control regulation in the health care sector." Thesis, Stockholms universitet, Juridiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-156879.
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This thesis is about access control in the health care sector. Access control is a function in It-systems that allows authorized users to access data they have right to access, prevents unauthorized users from accessing data and prevents authorized users from disclosing data unlawfully. One of the pillars of access control is that a user only is authorized to access data that he or she needs to perform a task. This describes the principle of least privilege and its objective is to ensure data's confidentiality and integrity. In the health care sector where an increasing number of public and private actors are processing sensitive data the application of this principle is essential to protect patients' privacy and confidence in the system. The lawmaker has incorporated the principle of least privilege in legal bodies such as the General Data Protection Regulation, Patient Data Act and the regulation of registers that allow processing of health data. This thesis examines how the lawmaker has incorporated the principle of least privilege to protect health data. Therefore, it examines access control regulation, in particular, requirements on management of access rights and log audits. The lawmaker has applied this principle through requirements on the system that should be incorporated by default and through requirements on management of access rights. The conclusion is that given that the tendency in health care, like in other sectors, is toward automation and more focus on self-care, the requirements should be directed more to systems than medical staff.
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Leever, William J. "The Effects of Attention Control on Emotion Regulation." Xavier University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=xavier1459345217.
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Zhu, Yongjie. "Constrained nonlinear model predictive control for vehicle regulation." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1222177849.
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Bayer, Travis Scott Arnold Frances Hamilton Smolke Christina D. "Synthetic control and genetic regulation of ecological strategy /." Diss., Pasadena, Calif. : California Institute of Technology, 2009. http://resolver.caltech.edu/CaltechETD:etd-10162008-131654.
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